#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P03950 uniprotkb:O14578 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-8623109|ensembl:ENSP00000261833|uniprotkb:Q6XUH8|intact:MINT-2795177|uniprotkb:Q2M5E1|uniprotkb:Q9UPZ7|uniprotkb:Q86UQ9 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ctro_human(display_long)|uniprotkb:CIT(gene name)|psi-mi:CIT(display_short)|uniprotkb:KIAA0949(gene name synonym)|uniprotkb:STK21(gene name synonym)|uniprotkb:CRIK(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 21(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000122966(gene)|ensembl:ENST00000261833(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037708|mint:O14578|reactome:R-HSA-5625900|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|refseq:NP_001193928.1|refseq:NP_009105.1 go:"GO:0005634"(nucleus) - function:Required for KIF14 localization to the central spindle and midbody. May play a role in cytokinesis. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system|comment:mint figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:yA7y17lwftFoF2/BfbtC3aanJaI9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O00148 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-348253|ensembl:ENSP00000242776|uniprotkb:Q9BVP6|uniprotkb:Q9H5W0|intact:EBI-2514455|uniprotkb:Q8N5M0|uniprotkb:B1Q2N1 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:dx39a_human(display_long)|uniprotkb:DEAD box protein 39(gene name synonym)|uniprotkb:Nuclear RNA helicase URH49(gene name synonym)|uniprotkb:DDX39A(gene name)|psi-mi:DDX39A(display_short)|uniprotkb:DDX39(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000123136(gene)|ensembl:ENST00000242776(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00148|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0042802"(identical protein binding)|refseq:NP_005795.2|refseq:XP_011525922.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:EOc5EPfkNVMrdfd9Xx/snoOfhas9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9H3U1 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9NR12 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-350517|uniprotkb:Q14250|uniprotkb:Q5XG82|uniprotkb:Q6NVZ5|uniprotkb:Q96C91|uniprotkb:Q9BXB8|uniprotkb:Q9BXB9|intact:EBI-2556830|ensembl:ENSP00000348099 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pdli7_human(display_long)|uniprotkb:LIM mineralization protein(gene name synonym)|uniprotkb:Protein enigma(gene name synonym)|uniprotkb:PDLIM7(gene name)|psi-mi:PDLIM7(display_short)|uniprotkb:ENIGMA(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_976227.1|refseq:NP_998801.1|refseq:NP_005442.2|ensembl:ENST00000355572|ensembl:ENSP00000347776|ensembl:ENSP00000348099|ensembl:ENST00000359895|ensembl:ENSP00000352964|ensembl:ENST00000393551|ensembl:ENSP00000377182|ensembl:ENST00000486828|ensembl:ENSP00000439157|ensembl:ENST00000493815|ensembl:ENSP00000431236|ensembl:ENSG00000196923(gene)|ensembl:ENST00000355841(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0031941"(filamentous actin)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051371"(muscle alpha-actinin binding)|go:"GO:0061061"(muscle structure development)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR036034|rcsb pdb:2Q3G|reactome:R-HSA-8853659 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:XBVF0Y1DFqIYbnt/e/rYqS/m4d09606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q00526 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1245761|ensembl:ENSP00000400088|ensembl:ENSP00000410561 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cdk3_human(display_long)|uniprotkb:CDK3(gene name)|psi-mi:CDK3(display_short)|uniprotkb:Cell division protein kinase 3(gene name synonym)|uniprotkb:CDKN3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001249.1|dip:DIP-686N|ensembl:ENSG00000250506(gene)|ensembl:ENST00000425876(transcript)|ensembl:ENST00000448471(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0045023"(G0 to G1 transition)|go:"GO:0051301"(cell division)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:1LFN go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:3ln4uWhDCiUiI0IcecfT+LKE3MY9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P24941 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P06493 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P17980 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-359720|uniprotkb:Q3B757|ensembl:ENSP00000298852|ensembl:ENSP00000481029|uniprotkb:Q3B865|uniprotkb:Q53HU5|uniprotkb:Q6GPG8|uniprotkb:Q6IBS1|uniprotkb:Q96HD3|uniprotkb:B2R8V1 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:prs6a_human(display_long)|uniprotkb:PSMC3(gene name)|psi-mi:PSMC3(display_short)|uniprotkb:TBP1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Proteasome subunit P50(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002795.2|ensembl:ENSG00000165916(gene)|ensembl:ENST00000298852(transcript)|ensembl:ENST00000619920(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:P17980|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|go:"GO:0036402"(proteasome-activating activity)|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-1236978|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27555N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:CejeauChmqeXNwBYF2cPz7mgMuw9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9Y6V7 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-719274|uniprotkb:Q53FJ1|uniprotkb:E7ENA0|uniprotkb:Q9BVQ8|ensembl:ENSP00000247003 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ddx49_human(display_long)|uniprotkb:DEAD box protein 49(gene name synonym)|uniprotkb:DDX49(gene name)|psi-mi:DDX49(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_061943.2|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|ensembl:ENST00000247003(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR014001(DEAD-like helicase, N-terminal)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006364"(rRNA processing)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9Y6V7|go:"GO:0030307"(positive regulation of cell growth)|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0044357"(regulation of rRNA stability)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|ensembl:ENSG00000105671(gene) go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Yfej1zXpPTue3eewQcR5OpNILeM9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P60842 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-73449|uniprotkb:P04765|uniprotkb:Q5U018|uniprotkb:Q61516|uniprotkb:B2R6L8|uniprotkb:D3DTP9|uniprotkb:J3QLC4|ensembl:ENSP00000293831 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:if4a1_human(display_long)|uniprotkb:EIF4A1(gene name)|psi-mi:EIF4A1(display_short)|uniprotkb:EIF4A(gene name synonym)|uniprotkb:DDX2A(gene name synonym)|uniprotkb:ATP-dependent RNA helicase eIF4A-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001407.1|refseq:NP_001191439.1|dip:DIP-29755N|ensembl:ENSG00000161960(gene)|ensembl:ENST00000293831(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:P60842|rcsb pdb:2G9N|rcsb pdb:2ZU6|rcsb pdb:3EIQ|rcsb pdb:5ZBZ|rcsb pdb:5ZC9|rcsb pdb:6ZMW|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:e+2gp47oHrpxFbrBFSM4qTf3r7E9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q96F07 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2433893|uniprotkb:A6NLT2|uniprotkb:Q53EN5|uniprotkb:Q9NTK4|uniprotkb:Q9ULQ2|uniprotkb:Q9UN29|uniprotkb:D3DQJ3|ensembl:ENSP00000479719 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cyfp2_human(display_long)|uniprotkb:CYFIP2(gene name)|psi-mi:CYFIP2(display_short)|uniprotkb:KIAA1168(gene name synonym)|uniprotkb:PIR121(gene name synonym)|uniprotkb:p53-inducible protein 121(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:XP_011532818.1|refseq:NP_001032410.1|refseq:NP_055191.2|refseq:NP_001278650.1|refseq:NP_001278651.1|refseq:XP_016864830.1|ensembl:ENSG00000055163(gene)|ensembl:ENST00000616178(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097484"(dendrite extension)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008081(Cytoplasmic FMR1-interacting)|interpro:IPR009828(Protein of unknown function DUF1394)|mint:Q96F07|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013149|reactome:R-HSA-9664422 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:EjzXClJ8fIqHFNSPrDRAjLT8bOM9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P31483 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1387216|uniprotkb:Q53SS9|uniprotkb:Q96B58|ensembl:ENSP00000401371 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tia1_human(display_long)|uniprotkb:TIA1(gene name)|psi-mi:TIA1(display_short)|uniprotkb:p40-TIA-1(gene name synonym)|uniprotkb:RNA-binding protein TIA-1(gene name synonym)|uniprotkb:T-cell-restricted intracellular antigen-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_071320.2|refseq:NP_071505.2|ensembl:ENSG00000116001(gene)|ensembl:ENST00000433529(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008143"("poly(A) binding")|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0097165"(nuclear stress granule)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034830|interpro:IPR034832|interpro:IPR035979|rcsb pdb:2MJN|rcsb pdb:3BS9|rcsb pdb:5ITH|rcsb pdb:5O2V|rcsb pdb:5O3J|rcsb pdb:6ELD|reactome:R-HSA-6803529|mint:P31483 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:d2ecwJo5sjSY6a/By3GM3B5A6PE9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P49368 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P26641 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P63010 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O60306 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2512328|ensembl:ENSP00000156471|uniprotkb:Q2YDX9|uniprotkb:Q6PIC8|uniprotkb:Q6IRU8|uniprotkb:A0JP17|uniprotkb:A5YKK3 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:aqr_human(display_long)|uniprotkb:AQR(gene name)|psi-mi:AQR(display_short)|uniprotkb:KIAA0560(gene name synonym)|uniprotkb:Intron-binding protein of 160 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000021776(gene)|ensembl:ENST00000156471(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016020"(membrane)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR026300|interpro:IPR027417|interpro:IPR032174|interpro:IPR041677|interpro:IPR041679|mint:O60306|rcsb pdb:4PJ3|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:7A5P|rcsb pdb:7ABI|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-72163|refseq:NP_055506.1|dip:DIP-53576N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:ZkD96by9PXxdrXPBXE+ZTaZeGnM9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P48643 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P09382 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1048875|uniprotkb:B2R5E8|uniprotkb:Q9UDK5|ensembl:ENSP00000215909 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:leg1_human(display_long)|uniprotkb:Lectin galactoside-binding soluble 1(gene name synonym)|uniprotkb:Beta-galactoside-binding lectin L-14-I(gene name synonym)|uniprotkb:S-Lac lectin 1(gene name synonym)|uniprotkb:Galaptin(gene name synonym)|uniprotkb:14 kDa lectin(gene name synonym)|uniprotkb:HPL(gene name synonym)|uniprotkb:HBL(gene name synonym)|uniprotkb:Putative MAPK-activating protein PM12(gene name synonym)|uniprotkb:LGALS1(gene name)|psi-mi:LGALS1(display_short)|uniprotkb:Lactose-binding lectin 1(gene name synonym)|uniprotkb:14 kDa laminin-binding protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002296.1|ensembl:ENST00000215909(transcript)|go:"GO:0002317"(plasma cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0009986"(cell surface)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030395"(lactose binding)|ensembl:ENSG00000100097(gene)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR044156|mint:P09382|rcsb pdb:1GZW|rcsb pdb:1W6M|rcsb pdb:1W6N|rcsb pdb:1W6O|rcsb pdb:1W6P|rcsb pdb:1W6Q|rcsb pdb:2KM2|rcsb pdb:2ZKN|rcsb pdb:3OY8|rcsb pdb:3OYW|rcsb pdb:3T2T|rcsb pdb:3W58|rcsb pdb:3W59|rcsb pdb:4Q1P|go:"GO:0031295"(T cell costimulation)|go:"GO:0034120"(positive regulation of erythrocyte aggregation)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043236"(laminin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0048678"(response to axon injury)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4Q1R|rcsb pdb:4Q26|rcsb pdb:4Q27|rcsb pdb:4Q2F|rcsb pdb:4XBL|rcsb pdb:4Y1U|rcsb pdb:4Y1V|rcsb pdb:4Y1X|rcsb pdb:4Y1Y|rcsb pdb:4Y1Z|rcsb pdb:4Y20|rcsb pdb:4Y22|rcsb pdb:4Y24|rcsb pdb:5MWT|rcsb pdb:5MWX|rcsb pdb:6B94|rcsb pdb:6F83|rcsb pdb:6M5Y|reactome:R-HSA-381426|reactome:R-HSA-8957275|dip:DIP-46153N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Sov3RfY2NOjdjuvdFlEd/vaNTMY9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9BTC8 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2461787|uniprotkb:Q9NSP2|uniprotkb:Q9ULF4|ensembl:ENSP00000385823 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mta3_human(display_long)|uniprotkb:MTA3(gene name)|psi-mi:MTA3(display_short)|uniprotkb:KIAA1266(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001269684.1|refseq:NP_001269685.1|refseq:NP_065795.1|refseq:NP_001317371.1|dip:DIP-47460N|ensembl:ENST00000405094(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|interpro:IPR043151|mint:Q9BTC8|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191|ensembl:ENSG00000057935(gene) go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:wxPsfH6FguY8n4PFwaj1iJNTWPc9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13330 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-714236|uniprotkb:Q8NFI8|uniprotkb:Q96GI8|uniprotkb:A5PLK4|intact:EBI-28976623|ensembl:ENSP00000333633|uniprotkb:Q86SW2 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mta1_human(display_long)|uniprotkb:MTA1(gene name)|psi-mi:MTA1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001190187.1|refseq:NP_004680.2|ensembl:ENSP00000333633|ensembl:ENST00000405646|ensembl:ENSP00000384180|ensembl:ENST00000438610|ensembl:ENSP00000393438|ensembl:ENSG00000182979(gene)|ensembl:ENST00000331320(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|reactome:R-HSA-427389|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9679191|reactome:R-HSA-3232118|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016581"(NuRD complex)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR000949(ELM2)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR035170|interpro:IPR040138|mint:Q13330|rcsb pdb:4BKX|rcsb pdb:4PBY|rcsb pdb:4PBZ|rcsb pdb:4PC0|rcsb pdb:5FXY|rcsb pdb:5ICN|rcsb pdb:6G16|rcsb pdb:6ZRC|rcsb pdb:6ZRD|rcsb pdb:7AO8|go:"GO:0045475"(locomotor rhythm)|rcsb pdb:7AO9|rcsb pdb:7AOA|reactome:R-HSA-3214815|dip:DIP-41751N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:nDDSb5B6YCbq5/6qvgtnUWtP23M9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q92945 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1049099|uniprotkb:O00301|uniprotkb:Q59EZ9|uniprotkb:Q5U4P6|uniprotkb:Q9UNT5|uniprotkb:Q9UQH5|intact:EBI-5455671|ensembl:ENSP00000381216 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:fubp2_human(display_long)|uniprotkb:KH type-splicing regulatory protein(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:KHSRP(gene name)|psi-mi:KHSRP(display_short)|uniprotkb:FUBP2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_003676.2|ensembl:ENSG00000088247(gene)|ensembl:ENST00000398148(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0016020"(membrane)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0051028"(mRNA transport)|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR015096(Region of unknown function DUF1897)|interpro:IPR036612|mint:Q92945|rcsb pdb:2HH2|rcsb pdb:2HH3|rcsb pdb:2JVZ|rcsb pdb:2OPU|rcsb pdb:2OPV|rcsb pdb:4B8T|reactome:R-HSA-380994|reactome:R-HSA-450604|dip:DIP-48484N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:hlybJllTqSgPgtwwz3kc12zDYh49606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q15366 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-945799|uniprotkb:Q6PKG5|intact:EBI-9640573|uniprotkb:Q6IPF4|uniprotkb:B4DXP5|intact:EBI-2555278|uniprotkb:A8K7X6|uniprotkb:F8VYL7|uniprotkb:Q32Q82|uniprotkb:Q68Y55|uniprotkb:I6L8F9|uniprotkb:Q59HD4|uniprotkb:G3V0E8|ensembl:ENSP00000408949 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pcbp2_human(display_long)|uniprotkb:PCBP2(gene name)|psi-mi:PCBP2(display_short)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001122383.1|refseq:NP_114366.1|refseq:NP_005007.2|refseq:NP_001092090.1|refseq:NP_001122384.1|refseq:NP_001122385.1|refseq:NP_001122386.1|dip:DIP-58934N|ensembl:ENSG00000197111(gene)|ensembl:ENST00000439930(transcript)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016071"(mRNA metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0070062"(extracellular exosome)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15366|rcsb pdb:2AXY|rcsb pdb:2JZX|rcsb pdb:2P2R|rcsb pdb:2PQU|rcsb pdb:2PY9|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-936440 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:KWabGhH+pfSX5k0vzs3SXH8Agaw9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P31943 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351590|uniprotkb:Q6IBM4|uniprotkb:B3KW86|uniprotkb:D3DWQ2|ensembl:ENSP00000349168|ensembl:ENSP00000377082|ensembl:ENSP00000397797|ensembl:ENSP00000492076|ensembl:ENSP00000495786 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:hnrh1_human(display_long)|uniprotkb:HNRNPH1(gene name)|psi-mi:HNRNPH1(display_short)|uniprotkb:HNRPH(gene name synonym)|uniprotkb:HNRPH1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005511.1|refseq:NP_001244222.1|ensembl:ENSG00000169045(gene)|ensembl:ENSG00000284254(gene)|ensembl:ENST00000356731(transcript)|ensembl:ENST00000393432(transcript)|ensembl:ENST00000442819(transcript)|ensembl:ENST00000638505(transcript)|ensembl:ENST00000643310(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012996(Zinc finger, CHHC-type)|interpro:IPR035979|mint:P31943|rcsb pdb:2LXU|rcsb pdb:6DHS|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:XP_016864904.1|refseq:XP_016864905.1|refseq:XP_016864906.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:htzqOB7Mmjm+C/KTTaFqh54Rm/89606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q15021 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1044041|uniprotkb:Q8N6U3|ensembl:ENSP00000325017|uniprotkb:D3DUR4 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cnd1_human(display_long)|uniprotkb:NCAPD2(gene name)|psi-mi:NCAPD2(display_short)|uniprotkb:CAPD2(gene name synonym)|uniprotkb:KIAA0159(gene name synonym)|uniprotkb:Non-SMC condensin I complex subunit D2(gene name synonym)|uniprotkb:Chromosome condensation-related SMC-associated protein 1(gene name synonym)|uniprotkb:Chromosome-associated protein D2(gene name synonym)|uniprotkb:XCAP-D2 homolog(gene name synonym)|uniprotkb:CNAP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_055680.3|ensembl:ENSG00000010292(gene)|ensembl:ENST00000315579(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0051301"(cell division)|interpro:IPR007673(Non-SMC condensin subunit, XCAP-D2/Cnd1)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024324|interpro:IPR026971|interpro:IPR032682|mint:Q15021|reactome:R-HSA-2514853 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:lFz1E3CjOD76OsuGtokfR7Ujvnw9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P49915 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9BZZ5 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1048422|uniprotkb:O15441|uniprotkb:Q9Y4J7|uniprotkb:D3DR21|uniprotkb:B4DRJ2|uniprotkb:B4E283|uniprotkb:B4DGR0|ensembl:ENSP00000431391 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:api5_human(display_long)|uniprotkb:Fibroblast growth factor 2-interacting factor(gene name synonym)|uniprotkb:Protein XAGL(gene name synonym)|uniprotkb:Antiapoptosis clone 11 protein(gene name synonym)|uniprotkb:Cell migration-inducing gene 8 protein(gene name synonym)|uniprotkb:API5(gene name)|psi-mi:API5(display_short)|uniprotkb:MIG8(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001136402.1|refseq:NP_001136403.1|refseq:NP_006586.1|refseq:NP_001230676.1|ensembl:ENSG00000166181(gene)|ensembl:ENST00000531273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR008383(Apoptosis inhibitory 5)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|mint:Q9BZZ5|rcsb pdb:3U0R|rcsb pdb:3V6A|rcsb pdb:6L4O go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:WYNbM5GNolgFNszccnMEanszDgU9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q15365 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P25205 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P54886 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9Y230 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q5VTE0 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-877809 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ef1a3_human(display_long)|uniprotkb:EEF1A1P5(gene name)|psi-mi:EEF1A1P5(display_short)|uniprotkb:Eukaryotic elongation factor 1 A-like 3(gene name synonym)|uniprotkb:EEF1AL3(gene name synonym)|uniprotkb:Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR031157|reactome:R-HSA-156842|interpro:IPR027417 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:3t6tj3i+3CKTC1NsrHyBkeoRK789606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P68104 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13492 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2803688|uniprotkb:Q86XZ9|uniprotkb:O60700|uniprotkb:Q6GMQ6|intact:EBI-28967113|ensembl:ENSP00000377015|uniprotkb:B4DTM3|uniprotkb:E9PN05|uniprotkb:F8VPG7|uniprotkb:Q4LE54 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pical_human(display_long)|uniprotkb:CALM(gene name synonym)|uniprotkb:Clathrin assembly lymphoid myeloid leukemia protein(gene name synonym)|uniprotkb:PICALM(gene name)|psi-mi:PICALM(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENST00000356360|ensembl:ENSP00000348718|ensembl:ENSP00000377015|ensembl:ENST00000526033|ensembl:ENSP00000433846|ensembl:ENST00000528398|ensembl:ENSP00000434884|ensembl:ENST00000532317|ensembl:ENSP00000436958|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031224"(intrinsic component of membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0005634"(nucleus)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR030412|mint:Q13492|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9696264|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035459"(vesicle cargo loading)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048156"(tau protein binding)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0032050"(clathrin heavy chain binding)|ensembl:ENSG00000073921(gene)|ensembl:ENST00000393346(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070381"(endosome to plasma membrane transport vesicle)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097494"(regulation of vesicle size)|go:"GO:0097753"(membrane bending)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902959"(regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:1902963"(negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:0055072"(iron ion homeostasis)|refseq:NP_001008660.1|refseq:NP_001193875.1|refseq:NP_001193876.1|refseq:NP_009097.2|refseq:XP_005274388.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:UIZhYyYqmBCyN4xwPCl9PeCdK8Q9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P49959 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q15233 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q16576 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352227|ensembl:ENSP00000369427|intact:EBI-3505029|uniprotkb:Q5JP00 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:rbbp7_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:RBAP46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002884.1|ensembl:ENST00000380087(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q16576|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:7M3X|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8951664|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|ensembl:ENSG00000102054(gene)|refseq:NP_001185648.1|dip:DIP-436N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q09028 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-620823|uniprotkb:B4DRH0|ensembl:ENSP00000362592|uniprotkb:P31149|uniprotkb:Q53H02|uniprotkb:Q96BV9|uniprotkb:D3DPQ3|uniprotkb:B2R6G9 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:rbbp4_human(display_long)|uniprotkb:Retinoblastoma-binding protein 4(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p48(gene name synonym)|uniprotkb:Chromatin assembly factor 1 subunit C(gene name synonym)|uniprotkb:Chromatin assembly factor I p48 subunit(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP48(gene name synonym)|uniprotkb:RBBP4(gene name)|psi-mi:RBBP4(display_short)|uniprotkb:RBAP48(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000162521(gene)|ensembl:ENST00000373493(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0016589"(NURF complex)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033186"(CAF-1 complex)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043044"|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|mint:Q09028|rcsb pdb:2XU7|rcsb pdb:3GFC|rcsb pdb:4PBY|rcsb pdb:4PBZ|rcsb pdb:4PC0|rcsb pdb:4R7A|rcsb pdb:5FXY|rcsb pdb:5VTB|rcsb pdb:5WAI|rcsb pdb:5WAK|rcsb pdb:5XWR|rcsb pdb:5XXQ|rcsb pdb:5Y1U|rcsb pdb:6BW3|rcsb pdb:6BW4|rcsb pdb:6C23|rcsb pdb:6C24|rcsb pdb:6G16|rcsb pdb:6NQ3|rcsb pdb:6WKR|rcsb pdb:6ZRC|rcsb pdb:6ZRD|rcsb pdb:7AOA|rcsb pdb:7KSO|rcsb pdb:7KSR|rcsb pdb:7KTP|rcsb pdb:7M40|reactome:R-HSA-1362277|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-156711|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69656|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|interpro:IPR036322|refseq:NP_001128727.1|refseq:NP_001128728.1|refseq:NP_005601.1|dip:DIP-33495N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:CbyJMIjpW1A4sZijP0IGRYc8o4I9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13425 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-80411|ensembl:ENSP00000338191|uniprotkb:Q9BY09 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:sntb2_human(display_long)|uniprotkb:SNT2B2(gene name synonym)|uniprotkb:SNTB2(gene name)|psi-mi:SNTB2(display_short)|uniprotkb:D16S2531E(gene name synonym)|uniprotkb:SNTL(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 2(gene name synonym)|uniprotkb:Syntrophin-3(gene name synonym)|uniprotkb:Syntrophin-like(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR028550|interpro:IPR036034|interpro:IPR041428|mint:Q13425|rcsb pdb:2VRF|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|ensembl:ENSG00000168807(gene)|ensembl:ENST00000336278(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_006741.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:SABgmvArdLH93OpFobs/L3BleVY9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q8N163 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355410|uniprotkb:A6NL03|uniprotkb:Q6P0Q9|uniprotkb:Q8N3G7|uniprotkb:Q8N8M1|uniprotkb:Q8TF34|uniprotkb:Q9H9Q9|uniprotkb:Q9HD12|uniprotkb:Q9NT55|ensembl:ENSP00000310670|ensembl:ENSP00000373930|uniprotkb:B2RB79|uniprotkb:D3DSR6 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ccar2_human(display_long)|uniprotkb:CCAR2(gene name)|psi-mi:CCAR2(display_short)|uniprotkb:Cell division cycle and apoptosis regulator protein 2(gene name synonym)|uniprotkb:DBC1(gene name synonym)|uniprotkb:DBIRD complex subunit KIAA1967(gene name synonym)|uniprotkb:Deleted in breast cancer gene 1 protein(gene name synonym)|uniprotkb:KIAA1967(gene name synonym)|uniprotkb:p30 DBC(gene name synonym)|uniprotkb:NET35(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_066997.3|ensembl:ENSG00000158941(gene)|ensembl:ENST00000308511(transcript)|ensembl:ENST00000389279(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005819"(spindle)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008380"(RNA splicing)|go:"GO:0009411"(response to UV)|go:"GO:0016055"(Wnt signaling pathway)|interpro:IPR028811|mint:Q8N163|reactome:R-HSA-3371453|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032784"(regulation of DNA-templated transcription, elongation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0044609"(DBIRD complex)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090311"(regulation of protein deacetylation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000003"(positive regulation of DNA damage checkpoint)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|dip:DIP-38122N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:GL+fD8W0kadrYrBkuMqoKgbbITU9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9UHX1 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1053259|uniprotkb:Q969E7|uniprotkb:Q96D94|uniprotkb:Q96H63|uniprotkb:Q99628|uniprotkb:Q9NZA0|uniprotkb:Q9UJY7|uniprotkb:A8K8K8|ensembl:ENSP00000434359|ensembl:ENSP00000484860 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:puf60_human(display_long)|uniprotkb:"60 kDa poly(U)-binding-splicing factor"(gene name synonym)|uniprotkb:FUSE-binding protein-interacting repressor(gene name synonym)|uniprotkb:Siah-binding protein 1(gene name synonym)|uniprotkb:Ro-binding protein 1(gene name synonym)|uniprotkb:PUF60(gene name)|psi-mi:PUF60(display_short)|uniprotkb:SIAHBP1(gene name synonym)|uniprotkb:FIR(gene name synonym)|uniprotkb:ROBPI(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001129505.1|refseq:NP_055096.2|refseq:NP_510965.1|refseq:NP_001258026.1|refseq:NP_001258028.1|refseq:NP_001258029.1|refseq:NP_001258025.1|refseq:NP_001258027.1|interpro:IPR034211|interpro:IPR034212|interpro:IPR035979|mint:Q9UHX1|rcsb pdb:2DNY|rcsb pdb:2KXF|rcsb pdb:2KXH|rcsb pdb:2QFJ|rcsb pdb:3DXB|rcsb pdb:3UE2|ensembl:ENSG00000179950(gene)|ensembl:ENSG00000274081(gene)|ensembl:ENST00000526683(transcript)|ensembl:ENST00000620341(transcript)|rcsb pdb:3US5|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|rcsb pdb:3UWT|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006915"(apoptotic process)|go:"GO:0030054"(cell junction)|rcsb pdb:5KVY|rcsb pdb:5KW1|rcsb pdb:5KW6|rcsb pdb:5KWQ|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006532(Poly-U binding splicing factor, half-pint)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034209|rcsb pdb:6LUR|rcsb pdb:6SLO|reactome:R-HSA-72163|refseq:XP_016868728.1|refseq:XP_016868729.1|dip:DIP-34636N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:nL6ALA543VdThkempiJTWAOhoNA9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q8IXH7 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-536725|uniprotkb:Q9BYL2|uniprotkb:Q9H405|uniprotkb:Q9H888|uniprotkb:Q9H8T3|uniprotkb:Q9NVX5|uniprotkb:Q9P029|uniprotkb:Q9UGN1|uniprotkb:Q9UGN2|uniprotkb:Q9UGN3|uniprotkb:B4DE06 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:nelfd_human(display_long)|uniprotkb:NELFCD(gene name)|psi-mi:NELFCD(display_short)|uniprotkb:NELFD(gene name synonym)|uniprotkb:TH1(gene name synonym)|uniprotkb:TH1-like protein(gene name synonym)|uniprotkb:TH1L(gene name synonym)|uniprotkb:HSPC130(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016020"(membrane)|go:"GO:0032021"(NELF complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|interpro:IPR006942(TH1 protein)|rcsb pdb:5L3X|rcsb pdb:6GML|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|refseq:NP_945327.2|mint:Q8IXH7|dip:DIP-34061N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:5x+m/j9x6zagup2Ptb1uFoNtDUE9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P23246 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P56545 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-741533|uniprotkb:O43449|uniprotkb:Q5SQP7|uniprotkb:Q69YI3|uniprotkb:Q86SV0|uniprotkb:Q9H2T8|uniprotkb:A8K2X5|ensembl:ENSP00000338615|ensembl:ENSP00000410474|ensembl:ENSP00000434630|ensembl:ENSP00000436285|uniprotkb:D3DRF5|uniprotkb:Q8IY44|intact:EBI-11742664 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ctbp2_human(display_long)|uniprotkb:CTBP2(gene name)|psi-mi:CTBP2(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001077383.1|refseq:NP_001320.1|refseq:NP_073713.2|refseq:NP_001307943.1|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006139(D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region)|interpro:IPR006140(D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding)|interpro:IPR029753|interpro:IPR036291|interpro:IPR043322|mint:P56545|rcsb pdb:2OME|rcsb pdb:4LCJ|rcsb pdb:6WKW|reactome:R-HSA-4641265|reactome:R-HSA-5339700|reactome:R-HSA-9662360|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051287"(NAD binding)|go:"GO:0098684"(photoreceptor ribbon synapse)|ensembl:ENSG00000175029(gene)|ensembl:ENST00000337195(transcript)|ensembl:ENST00000411419(transcript)|ensembl:ENST00000494626(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|ensembl:ENST00000531469(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016616"(oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019079"(viral genome replication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|refseq:XP_011537653.1|refseq:XP_011537655.1|refseq:XP_011537656.1|refseq:XP_011537657.1|refseq:NP_001307941.1|refseq:NP_001307942.1|refseq:XP_005269618.1|refseq:XP_005269621.1|refseq:XP_005269624.1|refseq:XP_005269625.1|refseq:XP_005269626.1|refseq:XP_005269628.1|refseq:XP_005269629.1|refseq:NP_001277143.1|refseq:NP_001277144.1|refseq:XP_006717705.1|refseq:XP_016871245.1|refseq:XP_016871246.1|dip:DIP-42104N|refseq:XP_011537651.1 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:6sKiqjMRW/ViEvTbQJoaUjgvZtc9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13416 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P50991 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356876|uniprotkb:O14870|uniprotkb:Q96C51|uniprotkb:Q53QP9|uniprotkb:B2R6I3|uniprotkb:B7Z8B1|uniprotkb:F5H5W3|ensembl:ENSP00000377958 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpd_human(display_long)|uniprotkb:CCT4(gene name)|psi-mi:CCT4(display_short)|uniprotkb:CCTD(gene name synonym)|uniprotkb:SRB(gene name synonym)|uniprotkb:CCT-delta(gene name synonym)|uniprotkb:Stimulator of TAR RNA-binding(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363232|imex:IM-25826-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006421.2|refseq:NP_001243650.1|dip:DIP-32971N|ensembl:ENSG00000115484(gene)|ensembl:ENST00000394440(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042470"(melanosome)|go:"GO:0042995"(cell projection)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012717(T-complex protein 1, delta subunit)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50991|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR017998 go:"GO:0005634"(nucleus) - - figure legend:T1|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Erg8Zzajt1WbrByS9LR4NAhZrXM9606 rigid:5CB4371arcHbhpMQvItvqPcvJ44 false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P33993 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P53597 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1237145|uniprotkb:Q9BWB0|uniprotkb:Q9UNP6|ensembl:ENSP00000377446 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:suca_human(display_long)|uniprotkb:SUCLG1(gene name)|psi-mi:SUCLG1(display_short)|uniprotkb:Succinyl-CoA synthetase subunit alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_003840.2|ensembl:ENSG00000163541(gene)|ensembl:ENST00000393868(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0009361"("succinate-CoA ligase complex (ADP-forming)")|interpro:IPR003781(CoA-binding)|interpro:IPR005810(Succinyl-CoA ligase, alpha subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|interpro:IPR033847|interpro:IPR036291|mint:P53597|rcsb pdb:6G4Q|rcsb pdb:6WCV|reactome:R-HSA-71403 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:fti5qbvs9ndhRyZyoPEuTxMpEgo9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P62714 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1044367|ensembl:ENSP00000221138|uniprotkb:P11082|uniprotkb:D3DSV4|uniprotkb:Q6FHK5 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pp2ab_human(display_long)|uniprotkb:PPP2CB(gene name)|psi-mi:PPP2CB(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001009552.1|ensembl:ENSG00000104695(gene)|ensembl:ENST00000221138(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|go:"GO:0006470"(protein dephosphorylation)|interpro:IPR029052|mint:P62714|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5675221|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-6804757|reactome:R-HSA-5673000|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|dip:DIP-42325N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:ZWmB6it7rr0BS5sy38IxZ9QdR7U9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P67775 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-712311|ensembl:ENSP00000418447|uniprotkb:P05323|uniprotkb:P13197 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pp2aa_human(display_long)|uniprotkb:PPP2CA(gene name)|psi-mi:PPP2CA(display_short)|uniprotkb:Replication protein C(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000113575(gene)|ensembl:ENST00000481195(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904526"(regulation of microtubule binding)|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P67775|rcsb pdb:2IAE|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3FGA|rcsb pdb:3K7W|rcsb pdb:3P71|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4IYP|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2995383|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|rcsb pdb:3K7V|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_002706.1|dip:DIP-29395N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Zynydo3YUFioN2iUl6oR0nVJ4YY9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P25705 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351437|uniprotkb:Q53XX6|uniprotkb:Q8IXV2|uniprotkb:Q96FB4|uniprotkb:Q96HW2|uniprotkb:Q96IR6|uniprotkb:Q9BTV8|intact:EBI-11032691|uniprotkb:A8K092|uniprotkb:B4DY56|uniprotkb:K7ENP3|ensembl:ENSP00000282050|ensembl:ENSP00000381736 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:atpa_human(display_long)|uniprotkb:ATP5F1A(gene name)|psi-mi:ATP5F1A(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:ATP5A(gene name synonym)|uniprotkb:ATP5A1(gene name synonym)|uniprotkb:ATP5AL2(gene name synonym)|uniprotkb:ATPM(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001244263.1|refseq:NP_001001937.1|refseq:NP_004037.1|refseq:NP_001001935.1|refseq:NP_001244264.1|dip:DIP-32871N|ensembl:ENSG00000152234(gene)|ensembl:ENST00000282050(transcript)|ensembl:ENST00000398752(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR020003|interpro:IPR023366|interpro:IPR027417|interpro:IPR033732|interpro:IPR036121|interpro:IPR038376|mint:P25705|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-8949613 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Sy/Ii5ea+ilCKGBnIEMn133Vogc9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q00325 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-358549|uniprotkb:Q96A03|intact:EBI-28967087|ensembl:ENSP00000228318|ensembl:ENSP00000447310|uniprotkb:Q7Z7N7|uniprotkb:B3KS34 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mpcp_human(display_long)|uniprotkb:SLC25A3(gene name)|psi-mi:SLC25A3(display_short)|uniprotkb:PHC(gene name synonym)|uniprotkb:OK/SW-cl.48(orf name)|uniprotkb:Phosphate transport protein(gene name synonym)|uniprotkb:Solute carrier family 25 member 3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENST00000188376|ensembl:ENSP00000188376|ensembl:ENSP00000228318|ensembl:ENST00000401722|ensembl:ENSP00000383898|ensembl:ENST00000549338|ensembl:ENSP00000447740|ensembl:ENSP00000447310|ensembl:ENST00000552981|ensembl:ENSP00000448708|refseq:NP_002626.1|refseq:NP_005879.1|refseq:NP_998776.1|ensembl:ENSG00000075415(gene)|ensembl:ENST00000228318(transcript)|ensembl:ENST00000551917(transcript)|go:"GO:0005315"(inorganic phosphate transmembrane transporter activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015317"("phosphate:proton symporter activity")|go:"GO:0016020"(membrane)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990547"(mitochondrial phosphate ion transmembrane transport)|interpro:IPR018108|interpro:IPR023395|interpro:IPR044677|mint:Q00325 go:"GO:0005737"(cytoplasm) - crc64:78714C85931B22D5 figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:f8THTDwNPyGowC9gCT9ZsizQ6qs9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P48643 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355710|uniprotkb:A8JZY8|ensembl:ENSP00000280326|uniprotkb:A8K2X8|uniprotkb:B4DYD8 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpe_human(display_long)|uniprotkb:CCT5(gene name)|psi-mi:CCT5(display_short)|uniprotkb:CCTE(gene name synonym)|uniprotkb:KIAA0098(gene name synonym)|uniprotkb:CCT-epsilon(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_036205.1|ensembl:ENSG00000150753(gene)|ensembl:ENST00000280326(transcript)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|refseq:NP_001293084.1|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009615"(response to virus)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P48643|rcsb pdb:5UYX|rcsb pdb:5UYZ|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|interpro:IPR012718(T-complex protein 1, epsilon subunit)|dip:DIP-31181N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:u7uFkOYrDKL0gGvC24p34tQHhcw9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P25685 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P11172 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-723452|uniprotkb:O00758|uniprotkb:O00759|uniprotkb:O00760|uniprotkb:Q16862|uniprotkb:Q9H3Q2|uniprotkb:Q9UG49|ensembl:ENSP00000232607|uniprotkb:B5LY68|uniprotkb:B5LY72 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:umps_human(display_long)|uniprotkb:UMPS(gene name)|psi-mi:UMPS(display_short)|uniprotkb:OK/SW-cl.21(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_000364.1|interpro:IPR014732(Orotidine 5'-phosphate decarboxylase, subfamily 1, core)|interpro:IPR018089|interpro:IPR023031|interpro:IPR029057|mint:P11172|rcsb pdb:2EAW|rcsb pdb:2JGY|rcsb pdb:2P1F|rcsb pdb:2QCC|rcsb pdb:2QCD|rcsb pdb:2QCE|rcsb pdb:2QCF|rcsb pdb:2QCG|rcsb pdb:2QCH|rcsb pdb:2QCL|go:"GO:0006222"(UMP biosynthetic process)|rcsb pdb:2QCM|rcsb pdb:2QCN|rcsb pdb:2V30|rcsb pdb:2WNS|rcsb pdb:3BGG|rcsb pdb:3BGJ|rcsb pdb:3BK0|go:"GO:0007565"(female pregnancy)|rcsb pdb:3BVJ|rcsb pdb:3DBP|go:"GO:0007595"(lactation)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044205"('de novo' UMP biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR001754(Orotidine 5'-phosphate decarboxylase, core)|interpro:IPR004467(Orotate phosphoribosyl transferase)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:3EWU|rcsb pdb:3EWW|rcsb pdb:3EWY|rcsb pdb:3EWZ|rcsb pdb:3EX1|rcsb pdb:3EWX|rcsb pdb:3EX2|rcsb pdb:3EX3|rcsb pdb:3EX4|rcsb pdb:3EX6|rcsb pdb:3G3D|rcsb pdb:3G3M|rcsb pdb:3L0K|rcsb pdb:3L0N|rcsb pdb:3MI2|rcsb pdb:3MO7|rcsb pdb:3MW7|rcsb pdb:4HIB|rcsb pdb:4HKP|reactome:R-HSA-500753|ensembl:ENSG00000114491(gene)|ensembl:ENST00000232607(transcript)|go:"GO:0004588"(orotate phosphoribosyltransferase activity)|go:"GO:0004590"(orotidine-5'-phosphate decarboxylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|dip:DIP-29595N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:8HKx6eTv3pMPMJQzUhhFjyGXGZI9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P20336 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1045943|uniprotkb:Q9NYE1|uniprotkb:A8K0J4|ensembl:ENSP00000222256 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:rab3a_human(display_long)|uniprotkb:RAB3A(gene name)|psi-mi:RAB3A(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002857.1|ensembl:ENSG00000105649(gene)|ensembl:ENST00000222256(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0003016"(respiratory system process)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009306"(protein secretion)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030324"(lung development)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0030424"(axon)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0031630"(regulation of synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0043195"(terminal bouton)|go:"GO:0045054"(constitutive secretory pathway)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048790"(maintenance of presynaptic active zone structure)|go:"GO:0050975"(sensory perception of touch)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060201"(clathrin-sculpted acetylcholine transport vesicle membrane)|go:"GO:0060203"(clathrin-sculpted glutamate transport vesicle membrane)|go:"GO:0060478"(acrosomal vesicle exocytosis)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061670"(evoked neurotransmitter secretion)|go:"GO:0070083"(clathrin-sculpted monoamine transport vesicle membrane)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR027417|interpro:IPR037872|mint:P20336|reactome:R-HSA-181429|reactome:R-HSA-181430|reactome:R-HSA-210500|reactome:R-HSA-212676|interpro:IPR005225(Small GTP-binding protein)|reactome:R-HSA-264642|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|reactome:R-HSA-888590|reactome:R-HSA-9662360|refseq:XP_011526466.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:mByWzDHvitYqJ1l4Fjjuq55Y9TA9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O60884 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352957|ensembl:ENSP00000314030|uniprotkb:O14711|uniprotkb:B2R7L7 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:dnja2_human(display_long)|uniprotkb:DNAJA2(gene name)|psi-mi:DNAJA2(display_short)|uniprotkb:HIRIP4(gene name synonym)|uniprotkb:CPR3(gene name synonym)|uniprotkb:HIRA-interacting protein 4(gene name synonym)|uniprotkb:Cell cycle progression restoration gene 3 protein(gene name synonym)|uniprotkb:Dnj3(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-14(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000069345(gene)|ensembl:ENST00000317089(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713|mint:O60884|reactome:R-HSA-3371497|interpro:IPR018253|refseq:NP_005871.1|dip:DIP-33143N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:c+JdHn0cKVKqRZCvK6DRYWs+zkQ9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q12802 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1373806|uniprotkb:Q14572|uniprotkb:Q59FP6|uniprotkb:Q86W90|uniprotkb:Q8WXQ6|uniprotkb:Q96JP6|uniprotkb:Q96P79|uniprotkb:Q9Y5T0|uniprotkb:Q9Y5T6|intact:EBI-28978093|ensembl:ENSP00000378026 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:akp13_human(display_long)|uniprotkb:Protein kinase A-anchoring protein 13(gene name synonym)|uniprotkb:Breast cancer nuclear receptor-binding auxiliary protein(gene name synonym)|uniprotkb:Human thyroid-anchoring protein 31(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor Lbc(gene name synonym)|uniprotkb:AKAP-Lbc(gene name synonym)|uniprotkb:p47(gene name synonym)|uniprotkb:Lymphoid blast crisis oncogene(gene name synonym)|uniprotkb:Non-oncogenic Rho GTPase-specific GTP exchange factor(gene name synonym)|uniprotkb:AKAP13(gene name)|psi-mi:AKAP13(display_short)|uniprotkb:BRX(gene name synonym)|uniprotkb:HT31(gene name synonym)|uniprotkb:LBC(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006729.4|refseq:NP_009131.2|ensembl:ENST00000361243|ensembl:ENSP00000354718|ensembl:ENSP00000378026|ensembl:ENST00000560302|ensembl:ENSP00000453634|refseq:NP_001257475.1|dip:DIP-180N|ensembl:ENSG00000170776(gene)|ensembl:ENST00000394518(transcript)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051168"(nuclear export)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060297"(regulation of sarcomere organization)|go:"GO:0060348"(bone development)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018459|interpro:IPR028852|interpro:IPR035899|interpro:IPR041020|mint:Q12802|rcsb pdb:2DRN|rcsb pdb:2LG1|rcsb pdb:4D0N|rcsb pdb:4D0O|rcsb pdb:6BCA|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:pHHpKUh10J/O/fp06k4NaNhJF6U9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P55209 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P17987 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356553|uniprotkb:Q15556|uniprotkb:Q5TCM3|uniprotkb:E1P5B2|ensembl:ENSP00000317334 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpa_human(display_long)|uniprotkb:CCTA(gene name synonym)|uniprotkb:TCP1(gene name)|psi-mi:TCP1(display_short)|uniprotkb:CCT1(gene name synonym)|uniprotkb:CCT-alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_110379.2|ensembl:ENSG00000120438(gene)|ensembl:ENST00000321394(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000792"(heterochromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000109"(regulation of macrophage apoptotic process)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044053"(translocation of peptides or proteins into host cell cytoplasm)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|interpro:IPR012715(T-complex protein 1, alpha subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|reactome:R-HSA-8950505|interpro:IPR027413|mint:P17987|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-33676N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:CYJ5rPjKOH3sAP+j0ckdHHu81g49606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13200 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O95163 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-347559|uniprotkb:Q9H327|uniprotkb:Q9UG87|uniprotkb:Q5JSV2|ensembl:ENSP00000363779|ensembl:ENSP00000501893 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:elp1_human(display_long)|uniprotkb:ELP1(gene name)|psi-mi:ELP1(display_short)|uniprotkb:IKAP(gene name synonym)|uniprotkb:IKBKAP(gene name synonym)|uniprotkb:p150(gene name synonym)|uniprotkb:IkappaB kinase complex-associated protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) dip:DIP-27579N|refseq:NP_003631.2|refseq:NP_001305289.1|ensembl:ENSG00000070061(gene)|ensembl:ENST00000374647(transcript)|ensembl:ENST00000675406(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0002926"(tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0033588"(elongator holoenzyme complex)|interpro:IPR006849(IKI3)|interpro:IPR015943(WD40/YVTN repeat-like)|mint:O95163|rcsb pdb:5CQR|reactome:R-HSA-3214847|go:"GO:0005829"(cytosol) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:hl+inV6TcN+DGu9CwE3SitkHiI09606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O43708 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-748043|uniprotkb:A6NNB8|uniprotkb:B2RCK3|uniprotkb:O15308|uniprotkb:O75430|uniprotkb:Q7Z610|uniprotkb:Q9BV63|uniprotkb:A8MWD7|uniprotkb:Q6IB17|uniprotkb:A6NED0 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:maai_human(display_long)|uniprotkb:Glutathione S-transferase zeta 1(gene name synonym)|uniprotkb:GSTZ1-1(gene name synonym)|uniprotkb:GSTZ1(gene name)|psi-mi:GSTZ1(display_short)|uniprotkb:MAAI(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) reactome:R-HSA-204174|refseq:NP_665877.1|refseq:NP_665878.2|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR005955(Maleylacetoacetate isomerase)|rcsb pdb:1FW1|refseq:NP_001299589.1|interpro:IPR034330|interpro:IPR034333|reactome:R-HSA-8963684|interpro:IPR004046(Glutathione S-transferase, C-terminal)|reactome:R-HSA-156590|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006559"(L-phenylalanine catabolic process)|go:"GO:0006572"(tyrosine catabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0016034"(maleylacetoacetate isomerase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Amk1E7K2v0Uo0k5XvLtBymmuxyk9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P17858 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-487243|uniprotkb:Q96A64|uniprotkb:Q96IH4|uniprotkb:Q9BR91|ensembl:ENSP00000269848 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pfkal_human(display_long)|uniprotkb:PFKL(gene name)|psi-mi:PFKL(display_short)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme B(gene name synonym)|uniprotkb:6-phosphofructokinase type B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001002021.2|refseq:NP_002617.3|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P17858|reactome:R-HSA-6798695|reactome:R-HSA-70171|ensembl:ENSG00000141959(gene)|ensembl:ENST00000349048(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:lP9/V5WcCl5rLpy4QEZnWkLCCcQ9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q99832 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q04837 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-353460|ensembl:ENSP00000265304|ensembl:ENSP00000419388|ensembl:ENSP00000419541|ensembl:ENSP00000419665|ensembl:ENSP00000420485|ensembl:ENSP00000458815|ensembl:ENSP00000459208|ensembl:ENSP00000459367|ensembl:ENSP00000460028|ensembl:ENSP00000461884|ensembl:ENSP00000480488 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ssbp_human(display_long)|uniprotkb:SSBP1(gene name)|psi-mi:SSBP1(display_short)|uniprotkb:SSBP(gene name synonym)|uniprotkb:PWP1-interacting protein 17(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_003134.1|refseq:NP_001243439.1|refseq:NP_001243440.1|refseq:NP_001243441.1|refseq:NP_001243442.1|ensembl:ENSG00000106028(gene)|ensembl:ENSG00000262771(gene)|ensembl:ENST00000265304(transcript)|ensembl:ENST00000465582(transcript)|ensembl:ENST00000481508(transcript)|ensembl:ENST00000484178(transcript)|ensembl:ENST00000498107(transcript)|ensembl:ENST00000570667(transcript)|ensembl:ENST00000571430(transcript)|ensembl:ENST00000574199(transcript)|ensembl:ENST00000575059(transcript)|ensembl:ENST00000576834(transcript)|ensembl:ENST00000612337(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0009295"(nucleoid)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0090297"(positive regulation of mitochondrial DNA replication)|go:"GO:1905776"(positive regulation of DNA helicase activity)|interpro:IPR000424(Primosome PriB/single-strand DNA-binding)|interpro:IPR011344(Single-strand DNA-binding)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q04837|rcsb pdb:1S3O|rcsb pdb:2DUD|rcsb pdb:3ULL|rcsb pdb:6RUP|reactome:R-HSA-2151201 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:W/7kbgBRtYcjJfr2XbA1OK9BOS49606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P11586 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P11142 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P49368 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q92888 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-465400|uniprotkb:O00513|uniprotkb:Q8N4J4|uniprotkb:Q96BF4|uniprotkb:Q96F17|uniprotkb:Q9BSB1|uniprotkb:Q6NX52|ensembl:ENSP00000346532 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:arhg1_human(display_long)|uniprotkb:ARHGEF1(gene name)|psi-mi:ARHGEF1(display_short)|uniprotkb:115 kDa guanine nucleotide exchange factor(gene name synonym)|uniprotkb:Sub1.5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_004697.2|refseq:NP_945328.1|refseq:NP_945353.1|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000076928(gene)|ensembl:ENST00000354532(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q92888|rcsb pdb:1IAP|rcsb pdb:1SHZ|rcsb pdb:3AB3|rcsb pdb:3ODO|rcsb pdb:3ODW|rcsb pdb:3ODX|rcsb pdb:3P6A go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:XIZmflM2cr80ZBD3FO21IDMnInE9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P63261 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351292|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|uniprotkb:Q5U032|uniprotkb:Q96E67|uniprotkb:A8K7C2|ensembl:ENSP00000505060|ensembl:ENSP00000505193|ensembl:ENSP00000505235|ensembl:ENSP00000506126|ensembl:ENSP00000506201|ensembl:ENSP00000506253|ensembl:ENSP00000458162|ensembl:ENSP00000458435|ensembl:ENSP00000459119|ensembl:ENSP00000459124|ensembl:ENSP00000460464|ensembl:ENSP00000460660|ensembl:ENSP00000461672|ensembl:ENSP00000466346|ensembl:ENSP00000477968 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:actg_human(display_long)|uniprotkb:ACTG1(gene name)|psi-mi:ACTG1(display_short)|uniprotkb:ACTG(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001186883.1|refseq:NP_001605.1|ensembl:ENST00000570382(transcript)|ensembl:ENSG00000184009(gene)|ensembl:ENST00000571721(transcript)|ensembl:ENST00000573283(transcript)|ensembl:ENST00000575087(transcript)|ensembl:ENST00000575659(transcript)|ensembl:ENST00000575842(transcript)|ensembl:ENST00000575994(transcript)|ensembl:ENST00000576544(transcript)|ensembl:ENST00000615544(transcript)|ensembl:ENST00000679480(transcript)|ensembl:ENST00000679778(transcript)|ensembl:ENST00000680227(transcript)|ensembl:ENST00000680727(transcript)|ensembl:ENST00000681052(transcript)|ensembl:ENST00000681842(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P63261|rcsb pdb:5JLH|rcsb pdb:6CXI|rcsb pdb:6CXJ|rcsb pdb:6G2T|rcsb pdb:6V62|rcsb pdb:6V63|rcsb pdb:6WK1|rcsb pdb:6WK2|reactome:R-HSA-1445148|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-3928665|reactome:R-HSA-418990|reactome:R-HSA-437239|reactome:R-HSA-4420097|reactome:R-HSA-445095|reactome:R-HSA-446353|reactome:R-HSA-5626467|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856828|reactome:R-HSA-9013418|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9664422 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q01813 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-359022|uniprotkb:B3KS15|uniprotkb:Q5VSR7|uniprotkb:Q5VSR8|ensembl:ENSP00000370517 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pfkap_human(display_long)|uniprotkb:PFKP(gene name)|psi-mi:PFKP(display_short)|uniprotkb:PFKF(gene name synonym)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme C(gene name synonym)|uniprotkb:6-phosphofructokinase type C(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002618.1|ensembl:ENSG00000067057(gene)|ensembl:ENST00000381125(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:Q01813|rcsb pdb:4RH3|rcsb pdb:4U1R|rcsb pdb:4WL0|rcsb pdb:4XYJ|rcsb pdb:4XYK|rcsb pdb:4XZ2|reactome:R-HSA-70171|refseq:NP_001229268.1|dip:DIP-45850N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:GNmWbFrQsTMRdVphWG+3DK3wxaA9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q5VTE0 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-877809 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ef1a3_human(display_long)|uniprotkb:EEF1A1P5(gene name)|psi-mi:EEF1A1P5(display_short)|uniprotkb:Eukaryotic elongation factor 1 A-like 3(gene name synonym)|uniprotkb:EEF1AL3(gene name synonym)|uniprotkb:Eukaryotic translation elongation factor 1 alpha-1 pseudogene 5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR031157|reactome:R-HSA-156842|interpro:IPR027417 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:3t6tj3i+3CKTC1NsrHyBkeoRK789606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P68104 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P04792 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N go:"GO:0005737"(cytoplasm) - crc64:1B4DC44A6F6606D5 figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P25205 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q86VP6 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13131 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1181405|uniprotkb:O00286|uniprotkb:Q5D0E1|uniprotkb:Q9UNQ4|uniprotkb:Q86VS1|intact:EBI-1383523|uniprotkb:A8MTQ6|uniprotkb:B2R7E1|ensembl:ENSP00000380317 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:aapk1_human(display_long)|uniprotkb:PRKAA1(gene name)|psi-mi:PRKAA1(display_short)|uniprotkb:AMPK1(gene name synonym)|uniprotkb:Tau-protein kinase PRKAA1(gene name synonym)|uniprotkb:Acetyl-CoA carboxylase kinase(gene name synonym)|uniprotkb:Hydroxymethylglutaryl-CoA reductase kinase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006242.5|refseq:NP_996790.3|ensembl:ENSG00000132356(gene)|ensembl:ENST00000397128(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003682"(chromatin binding)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006914"(autophagy)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0009411"(response to UV)|go:"GO:0009631"(cold acclimation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031000"(response to caffeine)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031669"(cellular response to nutrient levels)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033135"(regulation of peptidyl-serine phosphorylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0038183"(bile acid signaling pathway)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0046318"(negative regulation of glucosylceramide biosynthetic process)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0047322"("[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity")|go:"GO:0048156"(tau protein binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050405"([acetyl-CoA carboxylase] kinase activity)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0061744"(motor behavior)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0062028"(regulation of stress granule assembly)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120188"(regulation of bile acid secretion)|go:"GO:1901563"(response to camptothecin)|go:"GO:1903109"(positive regulation of mitochondrial transcription)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904428"(negative regulation of tubulin deacetylation)|go:"GO:1904486"(response to 17alpha-ethynylestradiol)|go:"GO:2000758"(positive regulation of peptidyl-lysine acetylation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR028797|interpro:IPR032270|interpro:IPR039137|mint:Q13131|rcsb pdb:4RED|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:5EZV|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1632852|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|reactome:R-HSA-9619483|dip:DIP-39973N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:isWWA5k0AqbXwXq5Bj+pk0joegU9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O95373 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P46821 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-764611|uniprotkb:A2BDK5|ensembl:ENSP00000296755 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:map1b_human(display_long)|uniprotkb:MAP1B(gene name)|psi-mi:MAP1B(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005900.2|dip:DIP-33474N|ensembl:ENSG00000131711(gene)|ensembl:ENST00000296755(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001764"(neuron migration)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009987"(cellular process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0021700"(developmental maturation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0033189"(response to vitamin A)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043196"(varicosity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0017085"(response to insecticide)|go:"GO:0045202"(synapse)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0051915"(induction of synaptic plasticity by chemical substance)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097457"(hippocampal mossy fiber)|interpro:IPR000102(Neuraxin/MAP1B repeat)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR027321|mint:P46821|interpro:IPR026074 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:uSRzrWaYU/dmkItUkCK4zex+/TM9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P10809 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P52701 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-395529|uniprotkb:O43706|uniprotkb:O43917|uniprotkb:Q8TCX4|uniprotkb:Q9BTB5|ensembl:ENSP00000234420|uniprotkb:B4DF41|uniprotkb:B4E3I4|uniprotkb:F5H2F9 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:msh6_human(display_long)|uniprotkb:MSH6(gene name)|psi-mi:MSH6(display_short)|uniprotkb:MutS-alpha 160 kDa subunit(gene name synonym)|uniprotkb:G/T mismatch-binding protein(gene name synonym)|uniprotkb:GTBP(gene name synonym)|uniprotkb:MutS protein homolog 6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_000170.1|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009411"(response to UV)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019899"(enzyme binding)|go:"GO:0030983"(mismatched DNA binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0035064"(methylated histone binding)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR017261(DNA mismatch repair protein Msh6)|interpro:IPR027417|interpro:IPR036187|interpro:IPR036678|mint:P52701|rcsb pdb:2GFU|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:6OQM|reactome:R-HSA-5358565|reactome:R-HSA-5632928|reactome:R-HSA-5632968|ensembl:ENSG00000116062(gene)|ensembl:ENST00000234420(transcript)|refseq:NP_001268421.1|refseq:NP_001268422.1|refseq:NP_001268423.1|dip:DIP-32972N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:YPpiWmh4fSjXapWgA/rXbMrLAGg9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P68366 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351772|uniprotkb:A8MUB1|uniprotkb:P05215|ensembl:ENSP00000248437|uniprotkb:B3KNQ6|intact:EBI-11134566 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tba4a_human(display_long)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Testis-specific alpha-tubulin(gene name synonym)|uniprotkb:Tubulin H2-alpha(gene name synonym)|uniprotkb:TUBA1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005991.1|ensembl:ENSG00000127824(gene)|ensembl:ENST00000248437(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68366|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001265481.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P68363 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-487083|intact:EBI-1384226|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:Q27I68|ensembl:ENSP00000336799|uniprotkb:Q8WU19 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tba1b_human(display_long)|uniprotkb:TUBA1B(gene name)|psi-mi:TUBA1B(display_short)|uniprotkb:Tubulin alpha-ubiquitous chain(gene name synonym)|uniprotkb:Alpha-tubulin ubiquitous(gene name synonym)|uniprotkb:Tubulin K-alpha-1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006073.2|ensembl:ENSG00000123416(gene)|ensembl:ENST00000336023(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|reactome:R-HSA-983189|go:"GO:0071353"(cellular response to interleukin-4)|interpro:IPR000217(Tubulin)|go:"GO:0045121"(membrane raft)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68363|rcsb pdb:2E4H|rcsb pdb:5IJ0|rcsb pdb:5IJ9|rcsb pdb:5N5N|rcsb pdb:6E7B|rcsb pdb:6E7C|rcsb pdb:6I2I|go:"GO:0051301"(cell division)|rcsb pdb:6J4V|rcsb pdb:6J8O|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|rcsb pdb:6S8L|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9013407|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-2132295|reactome:R-HSA-9668328 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:D4YpuLCXl/S+53qV7P7sF81aARY9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P27348 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9BRK5 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P68371 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-351356|uniprotkb:P05217|uniprotkb:A2BFA2|ensembl:ENSP00000341289 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tbb4b_human(display_long)|uniprotkb:TUBB4B(gene name)|psi-mi:TUBB4B(display_short)|uniprotkb:TUBB2C(gene name synonym)|uniprotkb:Tubulin beta-2 chain(gene name synonym)|uniprotkb:Tubulin beta-2C chain(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006079.1|ensembl:ENSG00000188229(gene)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|go:"GO:0005200"(structural constituent of cytoskeleton)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68371|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|ensembl:ENST00000340384(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003725"(double-stranded RNA binding) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:4LwMs7E7eILMjB9Z/1bstAp22CY9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9BUF5 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356735|uniprotkb:Q9HA42|ensembl:ENSP00000318697|uniprotkb:B3KM76 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tbb6_human(display_long)|uniprotkb:TUBB6(gene name)|psi-mi:TUBB6(display_short)|uniprotkb:Tubulin beta class V(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000176014(gene)|ensembl:ENST00000317702(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|refseq:NP_115914.1|interpro:IPR036525|interpro:IPR037103|mint:Q9BUF5|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001290453.1|refseq:NP_001290454.1|refseq:NP_001290455.1|refseq:NP_001290456.1|refseq:NP_001290457.1|refseq:NP_001290458.1|refseq:NP_001290459.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:/IC9o8wSAOu+lNgq44Qqu5hEof49606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P50990 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356507|uniprotkb:A6NN54|uniprotkb:Q4VBP8|uniprotkb:B4DEM7|uniprotkb:B4DQH4|ensembl:ENSP00000286788 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tcpq_human(display_long)|uniprotkb:CCT8(gene name)|psi-mi:CCT8(display_short)|uniprotkb:CCTQ(gene name synonym)|uniprotkb:KIAA0002(gene name synonym)|uniprotkb:CCT-theta(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-15(gene name synonym)|uniprotkb:C21orf112(gene name synonym)|uniprotkb:Chaperonin containing T-complex polypeptide 1 subunit 8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001269836.1|refseq:NP_001269838.1|refseq:NP_006576.2|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012721(T-complex protein 1, theta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P50990|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|ensembl:ENSG00000156261(gene)|ensembl:ENST00000286788(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016887"(ATP hydrolysis activity)|reactome:R-HSA-6798695|reactome:R-HSA-6814122|reactome:R-HSA-5620922|dip:DIP-38124N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:/TlB7Gk2Z9GPvfV3JBE0nWUF34Y9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9NPQ8 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-717509|uniprotkb:Q0P508|uniprotkb:Q2T9J1|uniprotkb:Q7Z352|uniprotkb:Q96EZ1|uniprotkb:Q96SZ2|uniprotkb:Q9H064|uniprotkb:Q9H5H3|uniprotkb:Q9H9E7|ensembl:ENSP00000432008 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ric8a_human(display_long)|uniprotkb:Protein Ric-8A(gene name synonym)|uniprotkb:RIC8A(gene name)|psi-mi:RIC8A(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001273063.1|refseq:NP_068751.4|refseq:XP_016873596.1|ensembl:ENSG00000177963(gene)|ensembl:ENST00000526104(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008542"(visual learning)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0070586"(cell-cell adhesion involved in gastrulation)|go:"GO:0071711"(basement membrane organization)|interpro:IPR008376(Synembryn)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019318|mint:Q9NPQ8|go:"GO:0001965"(G-protein alpha-subunit binding) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:jNCxRLnDY2aSw6SMtE82Tny1IE89606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q8N699 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2804634|ensembl:ENSP00000356214|uniprotkb:Q9H763|uniprotkb:Q8N396|uniprotkb:Q8TBE8 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:myct1_human(display_long)|uniprotkb:MTLC(gene name synonym)|uniprotkb:MTMC1(gene name synonym)|uniprotkb:Myc target in myeloid cells protein 1(gene name synonym)|uniprotkb:MYCT1(gene name)|psi-mi:MYCT1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000120279(gene)|ensembl:ENST00000367245(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|refseq:XP_011534451.1|refseq:XP_011534452.1|refseq:XP_011534453.1|refseq:XP_011534454.1|interpro:IPR029180|refseq:NP_079383.2|ensembl:ENSP00000356214|refseq:XP_016866808.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:/ppiWzZNtf2iURw/XIZ7ujOyIlQ9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P07437 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-350864|uniprotkb:P05218|uniprotkb:Q8WUC1|uniprotkb:Q9CY33|ensembl:ENSP00000339001|ensembl:ENSP00000373058|ensembl:ENSP00000399155|ensembl:ENSP00000400663|ensembl:ENSP00000401317|ensembl:ENSP00000406811|ensembl:ENSP00000410071|ensembl:ENSP00000410829 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tbb5_human(display_long)|uniprotkb:TUBB(gene name)|psi-mi:TUBB(display_short)|uniprotkb:Tubulin beta-5 chain(gene name synonym)|uniprotkb:TUBB5(gene name synonym)|uniprotkb:OK/SW-cl.56(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_821133.1|refseq:NP_001280141.1|refseq:NP_001280142.1|refseq:NP_001280143.1|refseq:NP_001280144.1|refseq:NP_001280145.1|ensembl:ENSG00000183311(gene)|ensembl:ENSG00000196230(gene)|ensembl:ENSG00000224156(gene)|ensembl:ENSG00000227739(gene)|ensembl:ENSG00000229684(gene)|ensembl:ENSG00000232421(gene)|ensembl:ENSG00000232575(gene)|ensembl:ENSG00000235067(gene)|ensembl:ENST00000327892(transcript)|ensembl:ENST00000383564(transcript)|ensembl:ENST00000419792(transcript)|ensembl:ENST00000421473(transcript)|ensembl:ENST00000422650(transcript)|ensembl:ENST00000422674(transcript)|ensembl:ENST00000432462(transcript)|ensembl:ENST00000436628(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0009987"(cellular process)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P07437|rcsb pdb:3QNZ|rcsb pdb:3QO0|rcsb pdb:5N5N|rcsb pdb:6I2I|rcsb pdb:6QUS|rcsb pdb:6QUY|rcsb pdb:6QVE|rcsb pdb:6QVJ|reactome:R-HSA-2565942|go:"GO:0050807"(regulation of synapse organization)|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-5620912|reactome:R-HSA-6798695|reactome:R-HSA-8854518|reactome:R-HSA-9679191|reactome:R-HSA-380320|dip:DIP-32772N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:B6pmb1dvCroZXGd/1Zazi+s72GA9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P11310 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-514381|uniprotkb:Q9NYF1|uniprotkb:Q5T4U4|ensembl:ENSP00000359878 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:acadm_human(display_long)|uniprotkb:Medium chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:ACADM(gene name)|psi-mi:ACADM(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_000007.1|refseq:NP_001120800.1|dip:DIP-34281N|ensembl:ENSG00000117054(gene)|ensembl:ENST00000370841(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0030424"(axon)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0051793"(medium-chain fatty acid catabolic process)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR034180|interpro:IPR036250|interpro:IPR037069|mint:P11310|rcsb pdb:1EGC|rcsb pdb:1EGD|rcsb pdb:1EGE|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:4P13|reactome:R-HSA-1989781|reactome:R-HSA-77288|reactome:R-HSA-77346|reactome:R-HSA-77348 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:rfmTmYKNQr6R6ikvfYovZIctoz49606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P43246 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9Y230 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O14773 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2800203|uniprotkb:Q5JAK6|uniprotkb:Q6UX56|uniprotkb:Q96C37|uniprotkb:Q71JP6|uniprotkb:Q53HT1|ensembl:ENSP00000299427 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tpp1_human(display_long)|uniprotkb:CLN2(gene name synonym)|uniprotkb:Tripeptidyl-peptidase I(gene name synonym)|uniprotkb:Tripeptidyl aminopeptidase(gene name synonym)|uniprotkb:Lysosomal pepstatin-insensitive protease(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 1 protein(gene name synonym)|uniprotkb:GIG1(orf name)|uniprotkb:UNQ267/PRO304(orf name)|uniprotkb:TPP1(gene name)|psi-mi:TPP1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_000382.3|ensembl:ENSG00000166340(gene)|ensembl:ENST00000299427(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007040"(lysosome organization)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008240"(tripeptidyl-peptidase activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045453"(bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0120146"(sulfatide binding)|go:"GO:1905146"(lysosomal protein catabolic process)|interpro:IPR015366(Peptidase S53, propeptide)|interpro:IPR030400|interpro:IPR036852|mint:O14773|rcsb pdb:1R60|rcsb pdb:3EDY|rcsb pdb:3EE6|reactome:R-HSA-381038|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|dip:DIP-47434N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:lhbu2VS1TqFCwSf8XBd6U17K1sU9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P35221 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-701918|uniprotkb:Q12795|intact:EBI-7950809|intact:MINT-4924748|uniprotkb:Q8N1C0|ensembl:ENSP00000304669 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ctna1_human(display_long)|uniprotkb:Cadherin-associated protein(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-13(gene name synonym)|uniprotkb:CTNNA1(gene name)|psi-mi:CTNNA1(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001894.2|refseq:NP_001277236.1|refseq:NP_001277238.1|refseq:NP_001277239.1|refseq:NP_001277241.1|refseq:NP_001310911.1|refseq:NP_001310912.1|refseq:NP_001310913.1|refseq:NP_001310916.1|refseq:NP_001310917.1|refseq:NP_001310918.1|refseq:NP_001310919.1|refseq:NP_001310920.1|refseq:NP_001310921.1|refseq:NP_001310922.1|refseq:NP_001310923.1|refseq:NP_001310924.1|refseq:NP_001310925.1|refseq:NP_001310926.1|refseq:NP_001310927.1|refseq:NP_001310928.1|refseq:NP_001310929.1|dip:DIP-515N|ensembl:ENSG00000044115(gene)|ensembl:ENST00000302763(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P35221|rcsb pdb:1H6G|rcsb pdb:4EHP|rcsb pdb:4IGG|rcsb pdb:6UPV|rcsb pdb:6V2O|rcsb pdb:6V2P|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-525793|reactome:R-HSA-5626467 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:N5rM8wI4ep+iZcnXU2g5wlJmJao9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P17813 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9BQE3 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1103245|ensembl:ENSP00000301072 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tba1c_human(display_long)|uniprotkb:TUBA1C(gene name)|psi-mi:TUBA1C(display_short)|uniprotkb:TUBA6(gene name synonym)|uniprotkb:Tubulin alpha-6 chain(gene name synonym)|uniprotkb:Alpha-tubulin 6(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|ensembl:ENSG00000167553(gene)|ensembl:ENST00000301072(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031982"(vesicle)|go:"GO:0051301"(cell division)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q9BQE3|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_116093.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:53r1CNUJNgCreVCw4riUsTPh+yw9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P24752 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1051459|uniprotkb:B2R6H1|uniprotkb:G3XAB4|uniprotkb:Q96FG8|ensembl:ENSP00000265838 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:thil_human(display_long)|uniprotkb:Acetoacetyl-CoA thiolase(gene name synonym)|uniprotkb:T2(gene name synonym)|uniprotkb:ACAT1(gene name)|psi-mi:ACAT1(display_short)|uniprotkb:ACAT(gene name synonym)|uniprotkb:MAT(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_000010.1|ensembl:ENSG00000075239(gene)|ensembl:ENST00000265838(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007420"(brain development)|go:"GO:0009725"(response to hormone)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015936"(coenzyme A metabolic process)|go:"GO:0015937"(coenzyme A biosynthetic process)|go:"GO:0016453"(C-acetyltransferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030955"(potassium ion binding)|go:"GO:0034435"(cholesterol esterification)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046356"(acetyl-CoA catabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072229"(metanephric proximal convoluted tubule development)|go:"GO:0120225"(coenzyme A binding)|go:"GO:1902224"(ketone body metabolic process)|go:"GO:1902860"(propionyl-CoA biosynthetic process)|interpro:IPR002155(Thiolase)|interpro:IPR016039(Thiolase-like)|interpro:IPR020610|interpro:IPR020613|interpro:IPR020615|interpro:IPR020616|interpro:IPR020617|rcsb pdb:2F2S|rcsb pdb:2IB7|rcsb pdb:2IB8|rcsb pdb:2IB9|rcsb pdb:2IBU|rcsb pdb:2IBW|rcsb pdb:2IBY|reactome:R-HSA-70895|reactome:R-HSA-77108|reactome:R-HSA-77111 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:UYAY+kDdcJqx/hrDFoXH9rgtm/E9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q16531 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-350322|uniprotkb:A6NG77|uniprotkb:O15176|uniprotkb:Q13289|ensembl:ENSP00000301764|ensembl:ENSP00000506223|ensembl:ENSP00000506685|uniprotkb:Q58F96|uniprotkb:B2R648|uniprotkb:B4DG00 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ddb1_human(display_long)|uniprotkb:DDB1(gene name)|psi-mi:DDB1(display_short)|uniprotkb:Damage-specific DNA-binding protein 1(gene name synonym)|uniprotkb:UV-damaged DNA-binding factor(gene name synonym)|uniprotkb:DDB p127 subunit(gene name synonym)|uniprotkb:DNA damage-binding protein a(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 1(gene name synonym)|uniprotkb:Xeroderma pigmentosum group E-complementing protein(gene name synonym)|uniprotkb:XPE-binding factor(gene name synonym)|uniprotkb:HBV X-associated protein 1(gene name synonym)|uniprotkb:XAP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001914.3|rcsb pdb:3I89|rcsb pdb:3I8C|rcsb pdb:3I8E|rcsb pdb:4A08|rcsb pdb:4A09|rcsb pdb:4A0A|rcsb pdb:4A0B|rcsb pdb:4A0K|rcsb pdb:4A0L|rcsb pdb:4A11|rcsb pdb:4CI1|rcsb pdb:4CI2|rcsb pdb:4CI3|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5JK7|rcsb pdb:5V3O|rcsb pdb:6BN7|ensembl:ENSG00000167986(gene)|ensembl:ENST00000301764(transcript)|ensembl:ENST00000680367(transcript)|ensembl:ENST00000681803(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030674"(protein-macromolecule adaptor activity)|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|rcsb pdb:6DSZ|rcsb pdb:6FCV|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|rcsb pdb:6SJ7|rcsb pdb:6TD3|rcsb pdb:6UD7|rcsb pdb:6UE5|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7LPS|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046726"(positive regulation by virus of viral protein levels in host cell)|go:"GO:0048511"(rhythmic process)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|interpro:IPR004871(Cleavage and polyadenylation specificity factor, A subunit, C-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018846|interpro:IPR031297|interpro:IPR036322|mint:Q16531|rcsb pdb:2B5L|rcsb pdb:2B5M|rcsb pdb:2B5N|rcsb pdb:2HYE|rcsb pdb:3E0C|rcsb pdb:3EI1|rcsb pdb:3EI2|rcsb pdb:3EI3|rcsb pdb:3EI4|rcsb pdb:3I7H|rcsb pdb:3I7K|rcsb pdb:3I7L|rcsb pdb:3I7N|rcsb pdb:3I7O|rcsb pdb:3I7P|dip:DIP-430N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:qgMjZqvlsbGIGn2qM/pnLTtGyGM9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P31153 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1050743|uniprotkb:Q53SP5|uniprotkb:A8K511|uniprotkb:D6W5L1|ensembl:ENSP00000303147|uniprotkb:B4DN45 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:metk2_human(display_long)|uniprotkb:Methionine adenosyltransferase 2(gene name synonym)|uniprotkb:Methionine adenosyltransferase II(gene name synonym)|uniprotkb:MAT2A(gene name)|psi-mi:MAT2A(display_short)|uniprotkb:AMS2(gene name synonym)|uniprotkb:MATA2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005902.1|rcsb pdb:5A1G|rcsb pdb:5A1I|rcsb pdb:5UGH|rcsb pdb:6FAJ|rcsb pdb:6FBN|rcsb pdb:6FBO|rcsb pdb:6FBP|rcsb pdb:6FCB|rcsb pdb:6FCD|rcsb pdb:6FWB|ensembl:ENSG00000168906(gene)|ensembl:ENST00000306434(transcript)|go:"GO:0004478"(methionine adenosyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006556"(S-adenosylmethionine biosynthetic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0034214"(protein hexamerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048269"(methionine adenosyltransferase complex)|go:"GO:0051291"(protein heterooligomerization)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR002133(S-adenosylmethionine synthetase)|rcsb pdb:6G6R|rcsb pdb:6P9V|rcsb pdb:6WKB|interpro:IPR022628|rcsb pdb:7BHR|rcsb pdb:7BHS|interpro:IPR022629|interpro:IPR022630|interpro:IPR022631|interpro:IPR022636|mint:P31153|rcsb pdb:2P02|rcsb pdb:4KTT|rcsb pdb:4KTV|rcsb pdb:4NDN|rcsb pdb:5A19|rcsb pdb:7BHT|rcsb pdb:7BHU|rcsb pdb:7BHV|rcsb pdb:7BHW|rcsb pdb:7BHX|rcsb pdb:7KCC|rcsb pdb:7KCE|rcsb pdb:7KCF|rcsb pdb:7KDA|rcsb pdb:7KDB|rcsb pdb:7L1A|reactome:R-HSA-156581 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:8QDKkbuHcvQtfzy2XkVjCKjTK709606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P22061 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-353343|uniprotkb:Q14661|uniprotkb:Q16556|uniprotkb:Q5VYC1|uniprotkb:Q5VYC2|uniprotkb:Q93061|uniprotkb:Q96II9|uniprotkb:Q99625|uniprotkb:Q9BQV7|uniprotkb:Q9BQV8|uniprotkb:Q9NP03|uniprotkb:A8K109|intact:EBI-2551555|uniprotkb:J3KP72|ensembl:ENSP00000356348|ensembl:ENSP00000420813 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pimt_human(display_long)|uniprotkb:PCMT1(gene name)|psi-mi:PCMT1(display_short)|uniprotkb:Protein-beta-aspartate methyltransferase(gene name synonym)|uniprotkb:Protein L-isoaspartyl/D-aspartyl methyltransferase(gene name synonym)|uniprotkb:L-isoaspartyl protein carboxyl methyltransferase(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001238978.1|refseq:NP_001238982.1|ensembl:ENSG00000120265(gene)|ensembl:ENST00000367378(transcript)|ensembl:ENST00000464889(transcript)|go:"GO:0004719"("protein-L-isoaspartate (D-aspartate) O-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006479"(protein methylation)|go:"GO:0030091"(protein repair)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|interpro:IPR000682("Protein-L-isoaspartate(D-aspartate) O-methyltransferase")|interpro:IPR029063|mint:P22061|rcsb pdb:1I1N|rcsb pdb:1KR5|reactome:R-HSA-5676934|refseq:NP_005380.2 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:wfsjVloc3sqDMXlvFAXQI6Fjilw9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q12805 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-536772|uniprotkb:Q541U7|uniprotkb:A8K3I4|uniprotkb:D6W5D2|ensembl:ENSP00000347596|ensembl:ENSP00000378058|uniprotkb:B4DW75 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:fbln3_human(display_long)|uniprotkb:Fibulin-3(gene name synonym)|uniprotkb:Fibrillin-like protein(gene name synonym)|uniprotkb:Extracellular protein S1-5(gene name synonym)|uniprotkb:EFEMP1(gene name)|psi-mi:EFEMP1(display_short)|uniprotkb:FBLN3(gene name synonym)|uniprotkb:FBNL(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000115380(gene)|ensembl:ENST00000355426(transcript)|ensembl:ENST00000394555(transcript)|go:"GO:0005006"(epidermal growth factor-activated receptor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007601"(visual perception)|go:"GO:0008083"(growth factor activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR026823|interpro:IPR032973|mint:Q12805|reactome:R-HSA-2129379|refseq:NP_001034437.1|refseq:NP_001034438.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:V32dS+EEp5Syu3A6lQJal0fg6UM9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9UNF1 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-725832|uniprotkb:O76058|uniprotkb:Q5BJF3|uniprotkb:Q8NAL6|uniprotkb:Q9H218|uniprotkb:Q9P0U9|uniprotkb:A6NMX0|uniprotkb:Q9UM52|ensembl:ENSP00000218439|ensembl:ENSP00000364193|ensembl:ENSP00000364198|ensembl:ENSP00000364209|ensembl:ENSP00000379526 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:magd2_human(display_long)|uniprotkb:MAGE-D2 antigen(gene name synonym)|uniprotkb:Breast cancer-associated gene 1 protein(gene name synonym)|uniprotkb:11B6(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated protein JCL-1(gene name synonym)|uniprotkb:MAGED2(gene name)|psi-mi:MAGED2(display_short)|uniprotkb:BCG1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_055414.2|refseq:NP_803182.1|refseq:NP_957516.1|ensembl:ENSG00000102316(gene)|ensembl:ENST00000218439(transcript)|ensembl:ENST00000375053(transcript)|ensembl:ENST00000375058(transcript)|ensembl:ENST00000375068(transcript)|ensembl:ENST00000396224(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007565"(female pregnancy)|go:"GO:0016020"(membrane)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0070294"(renal sodium ion absorption)|interpro:IPR002190(MAGE protein)|interpro:IPR028810|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|mint:Q9UNF1|reactome:R-HSA-114608|dip:DIP-50722N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:fXavezmKy58aGuVgzvDYjwNw3B89606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q14974 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-286758|uniprotkb:Q14637|uniprotkb:Q96J27|uniprotkb:Q53XN2|uniprotkb:B7ZAV6|uniprotkb:D3DTT3|intact:EBI-28976864|ensembl:ENSP00000290158|ensembl:ENSP00000464042 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:imb1_human(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Importin-90(gene name synonym)|uniprotkb:KPNB1(gene name)|psi-mi:KPNB1(display_short)|uniprotkb:NTF97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSP00000290158|ensembl:ENST00000535458|ensembl:ENSP00000438253|ensembl:ENST00000540627|ensembl:ENSP00000438964|ensembl:ENSP00000464042|refseq:NP_002256.2|refseq:NP_001263382.1|dip:DIP-6204N|ensembl:ENSG00000108424(gene)|ensembl:ENST00000290158(transcript)|ensembl:ENST00000583648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:Q14974|rcsb pdb:1F59|rcsb pdb:1IBR|rcsb pdb:1M5N|rcsb pdb:1O6O|rcsb pdb:1O6P|rcsb pdb:1QGK|rcsb pdb:1QGR|rcsb pdb:2P8Q|rcsb pdb:2Q5D|rcsb pdb:2QNA|rcsb pdb:3LWW|rcsb pdb:3W5K|rcsb pdb:6N88|rcsb pdb:6N89|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-1655829|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180746|reactome:R-HSA-2995383|reactome:R-HSA-6798695|reactome:R-HSA-909733|reactome:R-HSA-9615933|reactome:R-HSA-9636249 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:8NbS9qoyCx+M+X3KOe1+PQ3oSYk9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q92688 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-762428|uniprotkb:O00655|uniprotkb:P78458|uniprotkb:P78459|uniprotkb:B2R9C7|ensembl:ENSP00000345848 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:an32b_human(display_long)|uniprotkb:Acidic protein rich in leucines(gene name synonym)|uniprotkb:Silver-stainable protein SSP29(gene name synonym)|uniprotkb:ANP32B(gene name)|psi-mi:ANP32B(display_short)|uniprotkb:APRIL(gene name synonym)|uniprotkb:PHAPI2(gene name synonym)|uniprotkb:Putative HLA-DR-associated protein I-2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_006392.1|ensembl:ENSG00000136938(gene)|ensembl:ENST00000339399(transcript)|go:"GO:0001944"(vasculature development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0021591"(ventricular system development)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048839"(inner ear development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q92688|rcsb pdb:2ELL|rcsb pdb:2RR6|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal) go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:8eu0C8oHWUrZ28F2fIup9o5MDYk9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P06576 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-356231|ensembl:ENSP00000262030|uniprotkb:Q14283|uniprotkb:A8K4X0|intact:EBI-2322803 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:atpb_human(display_long)|uniprotkb:ATP5F1B(gene name)|psi-mi:ATP5F1B(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:ATP5B(gene name synonym)|uniprotkb:ATPMB(gene name synonym)|uniprotkb:ATPSB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000110955(gene)|ensembl:ENST00000262030(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|interpro:IPR020003|interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P06576|reactome:R-HSA-1268020|reactome:R-HSA-163210|reactome:R-HSA-2151201|reactome:R-HSA-8949613|go:"GO:0070062"(extracellular exosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|refseq:NP_001677.2 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:oLPUvG1tQkkzxzeAG6R0ZkZF+eg9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13509 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-350989|uniprotkb:Q9BTZ0|uniprotkb:Q9BW10|ensembl:ENSP00000320295|uniprotkb:A8K854 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tbb3_human(display_long)|uniprotkb:TUBB3(gene name)|psi-mi:TUBB3(display_short)|uniprotkb:TUBB4(gene name synonym)|uniprotkb:Tubulin beta-III(gene name synonym)|uniprotkb:Tubulin beta-4 chain(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001184110.1|refseq:NP_006077.2|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-6807878|ensembl:ENSG00000258947(gene)|ensembl:ENST00000315491(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007411"(axon guidance)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0042277"(peptide binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990890"(netrin receptor binding)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q13509|rcsb pdb:5IJ9|rcsb pdb:5JCO|rcsb pdb:6E7B|rcsb pdb:6S8L|rcsb pdb:6WSL|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|rcsb pdb:5IJ0|dip:DIP-31505N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:A69G+idFQmuzkmCsGyBtGVqglSo9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9H3U1 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P61160 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-353580|ensembl:ENSP00000260641|uniprotkb:O15142|uniprotkb:Q96C82|uniprotkb:B2RCP5|uniprotkb:D6W5F4|uniprotkb:E9PF41 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:arp2_human(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000138071(gene)|ensembl:ENST00000260641(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008306"(associative learning)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0016482"(cytosolic transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030478"(actin cap)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:NP_001005386.1|refseq:NP_005713.1|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:P61160|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33165N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q13838 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-348622|uniprotkb:B0S8C0|uniprotkb:Q5STB8|uniprotkb:O43496|uniprotkb:Q0EFA1|uniprotkb:Q2L6F9|uniprotkb:Q53GL9|uniprotkb:Q5RJ64|uniprotkb:Q5RJ66|uniprotkb:Q5ST94|uniprotkb:Q5STB4|uniprotkb:Q5STB5|uniprotkb:Q5STB7|uniprotkb:Q5STU4|uniprotkb:Q5STU5|uniprotkb:Q5STU6|uniprotkb:Q5STU8|uniprotkb:Q71V76|ensembl:ENSP00000373000|ensembl:ENSP00000379475|ensembl:ENSP00000383151|ensembl:ENSP00000383152|ensembl:ENSP00000387994|ensembl:ENSP00000388880|ensembl:ENSP00000390999|ensembl:ENSP00000391463|ensembl:ENSP00000393712|ensembl:ENSP00000394160|ensembl:ENSP00000398775|ensembl:ENSP00000399030|ensembl:ENSP00000400326|ensembl:ENSP00000404695|ensembl:ENSP00000405560|ensembl:ENSP00000407419|ensembl:ENSP00000411136|ensembl:ENSP00000411853|ensembl:ENSP00000416269 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:dx39b_human(display_long)|uniprotkb:UAP56(gene name synonym)|uniprotkb:DDX39B(gene name)|psi-mi:DDX39B(display_short)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:ATP-dependent RNA helicase p47(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:BAT1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_004631.1|refseq:NP_542165.1|ensembl:ENSG00000198563(gene)|ensembl:ENSG00000215425(gene)|ensembl:ENSG00000225073(gene)|ensembl:ENSG00000225859(gene)|ensembl:ENSG00000229496(gene)|ensembl:ENSG00000230624(gene)|ensembl:ENSG00000235439(gene)|ensembl:ENST00000383508(transcript)|ensembl:ENST00000396172(transcript)|ensembl:ENST00000400295(transcript)|ensembl:ENST00000400296(transcript)|ensembl:ENST00000412106(transcript)|ensembl:ENST00000412330(transcript)|ensembl:ENST00000413678(transcript)|ensembl:ENST00000414440(transcript)|ensembl:ENST00000415689(transcript)|ensembl:ENST00000416863(transcript)|ensembl:ENST00000430784(transcript)|ensembl:ENST00000431360(transcript)|ensembl:ENST00000441425(transcript)|ensembl:ENST00000445218(transcript)|ensembl:ENST00000448296(transcript)|ensembl:ENST00000453138(transcript)|ensembl:ENST00000456476(transcript)|ensembl:ENST00000456666(transcript)|ensembl:ENST00000458640(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q13838|rcsb pdb:1T5I|rcsb pdb:1T6N|rcsb pdb:1XTI|rcsb pdb:1XTJ|rcsb pdb:1XTK|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9013418 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:Cl/rf1oq31fZbLHC2foUXu9MBOE9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:O00148 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-348253|ensembl:ENSP00000242776|uniprotkb:Q9BVP6|uniprotkb:Q9H5W0|intact:EBI-2514455|uniprotkb:Q8N5M0|uniprotkb:B1Q2N1 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:dx39a_human(display_long)|uniprotkb:DEAD box protein 39(gene name synonym)|uniprotkb:Nuclear RNA helicase URH49(gene name synonym)|uniprotkb:DDX39A(gene name)|psi-mi:DDX39A(display_short)|uniprotkb:DDX39(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000123136(gene)|ensembl:ENST00000242776(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00148|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0042802"(identical protein binding)|refseq:NP_005795.2|refseq:XP_011525922.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:EOc5EPfkNVMrdfd9Xx/snoOfhas9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q04917 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P57088 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-1048629|uniprotkb:Q9H953|uniprotkb:B3KSS8|ensembl:ENSP00000422473|ensembl:ENSP00000427006|ensembl:ENSP00000441455 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tmm33_human(display_long)|uniprotkb:Protein DB83(gene name synonym)|uniprotkb:TMEM33(gene name)|psi-mi:TMEM33(display_short)|uniprotkb:DB83(gene name synonym)|uniprotkb:SHINC-3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_060596.2|refseq:XP_005248173.1|refseq:XP_005248174.1|ensembl:ENSG00000109133(gene)|ensembl:ENST00000325094(transcript)|ensembl:ENST00000504986(transcript)|ensembl:ENST00000513702(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061024"(membrane organization)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|interpro:IPR005344(Protein of unknown function UPF0121)|mint:P57088 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:FGc4/gpnYoRtlDJMxQWh5hXe5Ko9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q9Y265 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-353675|uniprotkb:P82276|uniprotkb:Q1KMR0|uniprotkb:Q53HK5|uniprotkb:Q53HL7|uniprotkb:Q53Y27|uniprotkb:Q9BSX9|uniprotkb:B2R5S0|ensembl:ENSP00000318297|ensembl:ENSP00000494621 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:ruvb1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short)|uniprotkb:NMP238(gene name synonym)|uniprotkb:TIP49(gene name synonym)|uniprotkb:TIP49A(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:Nuclear matrix protein 238(gene name synonym)|uniprotkb:54 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80H(gene name synonym)|uniprotkb:TIP60-associated protein 54-alpha(gene name synonym)|uniprotkb:INO80 complex subunit H(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_003698.1|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9Y265|rcsb pdb:2C9O|rcsb pdb:2XSZ|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-606279|ensembl:ENSG00000175792(gene)|ensembl:ENSG00000284901(gene)|ensembl:ENST00000322623(transcript)|ensembl:ENST00000643444(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001306013.1|dip:DIP-29937N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:+FA/xQTUldQoWGRgad9U8vZpTHw9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P0DMV8 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-11052499|uniprotkb:Q9UQM0|uniprotkb:Q5SP17|uniprotkb:Q5JQI4|uniprotkb:P08107|uniprotkb:B4E3B6|uniprotkb:Q9UQL9|uniprotkb:P19790|ensembl:ENSP00000364802|ensembl:ENSP00000382915|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:hs71a_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSX70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 1(gene name synonym)|uniprotkb:HSP72(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005336.3|refseq:NP_005337.2|ensembl:ENSG00000204389(gene)|ensembl:ENSG00000215328(gene)|ensembl:ENSG00000234475(gene)|ensembl:ENSG00000235941(gene)|ensembl:ENSG00000237724(gene)|ensembl:ENST00000375651(transcript)|ensembl:ENST00000400040(transcript)|ensembl:ENST00000430065(transcript)|ensembl:ENST00000433487(transcript)|ensembl:ENST00000441618(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0007041"(lysosomal transport)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031249"(denatured protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901029"(negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902380"(positive regulation of endoribonuclease activity)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P0DMV8|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:2LMG|rcsb pdb:3A8Y|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|rcsb pdb:3Q49|rcsb pdb:4IO8|rcsb pdb:4J8F|rcsb pdb:4PO2|rcsb pdb:4WV5|rcsb pdb:4WV7|rcsb pdb:5AQW|rcsb pdb:5AQX|rcsb pdb:5AQY|rcsb pdb:5AQZ|rcsb pdb:5AR0|rcsb pdb:5BN8|rcsb pdb:5BN9|rcsb pdb:5BPL|rcsb pdb:5BPM|rcsb pdb:5BPN|rcsb pdb:5GJJ|rcsb pdb:5MKR|rcsb pdb:5MKS|rcsb pdb:5XI9|rcsb pdb:5XIR|rcsb pdb:6FHK|rcsb pdb:6G3R|rcsb pdb:6G3S|rcsb pdb:6JPV|rcsb pdb:6K39|reactome:R-HSA-168330|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-450408|reactome:R-HSA-6798695 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:NFv4uj12xAWIr+OltarRlLDPr949606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P0DMV9 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-14100688|ensembl:ENSP00000364801|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000393087|ensembl:ENSP00000403530|uniprotkb:B4E3B6|uniprotkb:P08107|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:hs71b_human(display_long)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:HSP72(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) ensembl:ENSG00000204388(gene)|ensembl:ENSG00000212866(gene)|ensembl:ENSG00000224501(gene)|ensembl:ENSG00000231555(gene)|ensembl:ENSG00000232804(gene)|ensembl:ENST00000375650(transcript)|ensembl:ENST00000391548(transcript)|ensembl:ENST00000391555(transcript)|ensembl:ENST00000445736(transcript)|ensembl:ENST00000450744(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070370"(cellular heat acclimation)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0072562"(blood microparticle)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P0DMV9|rcsb pdb:4J8F|rcsb pdb:6FDT|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-6798695|refseq:NP_005336.3|refseq:NP_005337.2 go:"GO:0005737"(cytoplasm) - crc64:78F513118C96DE66 figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:NFv4uj12xAWIr+OltarRlLDPr949606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q3ZCM7 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-302558|ensembl:ENSP00000456206|intact:EBI-1390656|uniprotkb:Q5SQX9|uniprotkb:Q8WZ78 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:tbb8_human(display_long)|uniprotkb:TUBB8(gene name)|psi-mi:TUBB8(display_short)|uniprotkb:Tubulin beta 8 class VIII(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-9619483|ensembl:ENSG00000261456(gene)|ensembl:ENST00000568584(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007056"(spindle assembly involved in female meiosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072687"(meiotic spindle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q3ZCM7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|refseq:NP_817124.1 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:bTJnhl0qEm2ACoHQ7IOcn5Rx7xM9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:P12004 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P03950 uniprotkb:Q16401 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 intact:EBI-752143|uniprotkb:Q15045|uniprotkb:Q4VXG8|intact:EBI-10968906|uniprotkb:B4DZM8|ensembl:ENSP00000210313 psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:psmd5_human(display_long)|uniprotkb:26S proteasome subunit S5B(gene name synonym)|uniprotkb:26S protease subunit S5 basic(gene name synonym)|uniprotkb:PSMD5(gene name)|psi-mi:PSMD5(display_short)|uniprotkb:KIAA0072(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-16363282|imex:IM-25826-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) refseq:NP_005038.1|refseq:NP_001257356.1|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000095261(gene)|ensembl:ENST00000210313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0070682"(proteasome regulatory particle assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019538|mint:Q16401|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556 go:"GO:0005737"(cytoplasm) - - figure legend:t2|comment:"We have performed an immunoprecipitation coupled mass spectrometry (MS) analysis of the cytoplasmic and nuclear extracts from EA.hy926 cancer human cell line. The MS analysis of all biological replicates, identified many statistically significant potential hAng-interacting proteins in the two cellular compartments."|causality statement:"MI:2240"|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2021/06/18 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rogid:XLVvCeWct98fvc6ktvaWNXwt9dE9606 rigid:ZY9+/KfX7GhF5S1RT7bdAV/xFBY false - - - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:P12004 uniprotkb:P03950 intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym) psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-16363369|imex:IM-25826-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0005737"(cytoplasm) - - figure legend:F4|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rigid:JmrmQgpYnTxgyz6KpIZZilZRpS0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P12004 uniprotkb:P03950 intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym) psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-16363374|imex:IM-25826-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0005737"(cytoplasm) - - figure legend:F5|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rigid:JmrmQgpYnTxgyz6KpIZZilZRpS0 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P12004 uniprotkb:P03950 intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458 intact:EBI-525291|uniprotkb:Q8WXE7|uniprotkb:Q05CV1|uniprotkb:Q53X86|uniprotkb:Q6P5T2|ensembl:ENSP00000336762|ensembl:ENSP00000381077 psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym) psi-mi:angi_human(display_long)|uniprotkb:Ribonuclease 5(gene name synonym)|uniprotkb:ANG(gene name)|psi-mi:ANG(display_short)|uniprotkb:RNASE5(gene name synonym) psi-mi:"MI:0428"(imaging technique) Chatzileontiadou et al. (2017) pubmed:28777577|imex:IM-25826 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-16363386|imex:IM-25826-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N refseq:NP_001091046.1|refseq:NP_001136.1|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019843"(rRNA binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030426"(growth cone)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0032431"(activation of phospholipase A2 activity)|go:"GO:0042277"(peptide binding)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042592"(homeostatic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR001427(Pancreatic ribonuclease)|interpro:IPR023411|interpro:IPR023412|interpro:IPR036816|rcsb pdb:1A4Y|rcsb pdb:1ANG|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016477"(cell migration)|rcsb pdb:1AWZ|rcsb pdb:1B1E|rcsb pdb:1B1I|rcsb pdb:1B1J|rcsb pdb:1GV7|rcsb pdb:1H0D|rcsb pdb:1H52|rcsb pdb:1H53|rcsb pdb:1HBY|rcsb pdb:1K58|rcsb pdb:1K59|rcsb pdb:1K5A|rcsb pdb:1K5B|rcsb pdb:1UN3|rcsb pdb:1UN4|rcsb pdb:1UN5|rcsb pdb:2ANG|rcsb pdb:4AHD|rcsb pdb:4AHE|rcsb pdb:4AHF|rcsb pdb:4AHG|rcsb pdb:4AHH|rcsb pdb:4AHI|rcsb pdb:4AHJ|rcsb pdb:4AHK|rcsb pdb:4AHL|rcsb pdb:4AHM|rcsb pdb:4AHN|rcsb pdb:4AOH|rcsb pdb:4B36|rcsb pdb:5EOP|rcsb pdb:5EPZ|rcsb pdb:5EQO|rcsb pdb:5M9A|rcsb pdb:5M9C|rcsb pdb:5M9G|rcsb pdb:5M9J|rcsb pdb:5M9M|rcsb pdb:5M9P|rcsb pdb:5M9Q|rcsb pdb:5M9R|rcsb pdb:5M9S|rcsb pdb:5M9T|rcsb pdb:5M9V|reactome:R-HSA-418990|reactome:R-HSA-9708296|ensembl:ENSG00000214274(gene)|ensembl:ENST00000336811(transcript)|ensembl:ENST00000397990(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001878"(response to yeast)|go:"GO:0001890"(placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007154"(cell communication)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009725"(response to hormone)|go:"GO:0015629"(actin cytoskeleton) go:"GO:0005737"(cytoplasm) - - figure legend:F6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-ea.hy926)|taxid:9606(Homo sapiens EA.hy926) - 2017/08/18 2017/08/19 rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606 rogid:CSOTublnrV3DIGJfeyCfT14p8m89606 rigid:JmrmQgpYnTxgyz6KpIZZilZRpS0 false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining)