#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q92583	uniprotkb:P13501-PRO_0000005175	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-11712923	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640143|imex:IM-26339-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:table S2 CCL17 chip|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.6x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:0ByL812vy/YPA6ntDfSlAx/OBJE	false	biotin tag:?-?	mutation increasing interaction strength:26-26	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501-PRO_0000005175	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-11712923	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640391|imex:IM-26339-747	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:figure S2 and table S2 CCL17 chip|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.6x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:0ByL812vy/YPA6ntDfSlAx/OBJE	false	biotin tag:?-?	mutation increasing interaction strength:66-66	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501-PRO_0000005175	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-11712923	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640432|imex:IM-26339-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:table S2 CCL17 chip|kinetics:methylation decreases strength of binding with a dissociation constant KD = 145 ± 64 nM|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:145.0x10^-9(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:0ByL812vy/YPA6ntDfSlAx/OBJE	false	biotin tag:?-?	modified L-threonine residue:7-7	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501-PRO_0000005175	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-11712923	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640445|imex:IM-26339-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:table S2 CCL17 chip|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.6x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:0ByL812vy/YPA6ntDfSlAx/OBJE	false	biotin tag:?-?	mutation decreasing interaction strength:44-47	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776-PRO_0000351217	uniprotkb:P13501	intact:EBI-20561364	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:p02776-pro_0000351217(display_long)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Iroplact(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640456|imex:IM-26339-727	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2565740(chain-parent)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	chain-seq-start:48|chain-seq-end:101	-	figure legend:table S2 CCL5 chip|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.1x10^-6(molar)	2017/11/07	2018/05/16	rogid:8FKs98wULNJak32nSZKkbTNRSNY9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:k5SXZkLfGvWsqCvvFYPtRYCIrdI	false	mutation decreasing interaction strength:50-50	biotin tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P02776-PRO_0000351217	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-20561364	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:p02776-pro_0000351217(display_long)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Iroplact(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640478|imex:IM-26339-749	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	intact:EBI-2565740(chain-parent)	-	-	chain-seq-start:48|chain-seq-end:101	figure legend:table S2 CXCL12 chip|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:20.0x10^-6(molar)	2017/11/07	2018/05/16	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:8FKs98wULNJak32nSZKkbTNRSNY9606	rigid:/XmN/bXAN1SJ3kzVqdsZon54kI4	false	biotin tag:?-?	mutation decreasing interaction strength:50-50	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P13501-PRO_0000005175	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-11712923	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16640491|imex:IM-26339-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:table S2 CXCL4 chip|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:SvmegItHDpn/5uRP6MZ6BYYseEA	false	biotin tag:?-?	mutation decreasing interaction strength:26-26	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P13501-PRO_0000005175	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-11712923	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16671811|imex:IM-26339-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:table S2 CXCL4 chip|comment:methylation obliterated binding|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:SvmegItHDpn/5uRP6MZ6BYYseEA	false	biotin tag:?-?	modified L-threonine residue:7-7|mutation with no effect:66-66	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501-PRO_0000005175	uniprotkb:P02776	intact:EBI-11712923	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16671826|imex:IM-26339-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2848366(chain-parent)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	chain-seq-start:24|chain-seq-end:91	-	figure legend:table S2 CXCL4 chip|kinetics:muation obliterated binding|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.2x10^-6(molar)	2017/11/07	2018/05/16	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:SvmegItHDpn/5uRP6MZ6BYYseEA	false	mutation decreasing interaction strength:44-47	biotin tag:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16877537|imex:IM-26339-733	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.27x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	biotin tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16877537|imex:IM-26339-733	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.27x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	biotin tag:?-?	binding-associated region:56-75|mutation:57-57,73-73	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02776	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16877653|imex:IM-26339-755	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-6(molar)	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	biotin tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P13501	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16877653|imex:IM-26339-755	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.9x10^-6(molar)	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	biotin tag:?-?	mutation disrupting interaction strength:67-67,49-49|binding-associated region:48-67|mutation:65-65	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P13501	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20218627|imex:IM-26339-739	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.4x10^-6(molar)	2017/11/07	2018/05/16	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:eF3gaFgLIrlAzPQ4g7r1m+1XxYA	false	biotin tag:?-?	binding-associated region:1-33	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P13501	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20218627|imex:IM-26339-739	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:2.4x10^-6(molar)	2017/11/07	2018/05/16	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:eF3gaFgLIrlAzPQ4g7r1m+1XxYA	false	biotin tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561256|imex:IM-26339-761	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.24x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	biotin tag:?-?	binding-associated region:1-33	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561256|imex:IM-26339-761	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:0.24x10^-6(molar)	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	biotin tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P13501	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561285|imex:IM-26339-763	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.7x10^-6(molar)	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	biotin tag:?-?	binding-associated region:24-56	1	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02776	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561285|imex:IM-26339-763	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.7x10^-6(molar)	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	biotin tag:?-?	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O14625	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804161|imex:IM-26339-582	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:Av2aXvYF4NdBJ3a1qXBSLwyts3A	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P13500	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803805|imex:IM-26339-438	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:95.0x10^-9 ~40.0(molar)	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:XmSLLSeVaji6k1m/reGrBeI2RJ8	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q07325	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804136|imex:IM-26339-580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:5nJC+3zbZFL/3RY1nuVDRH7EWYM	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02775	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804123|imex:IM-26339-104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:27.0x10^-9 ~16.0(molar)	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:yOKqa9DyzZoLMUH4xUGOE5J3MwY	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P80162	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804111|imex:IM-26339-182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:/le+dwj1rYGgOd4jH4PcG3OQVyA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02776	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804098|imex:IM-26339-578	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.0x10^-9 ~2.0(molar)	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P19875	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804086|imex:IM-26339-360	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:1ESnC17m/bTKZAsUZX1+XUbOEFw	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q9UBD3	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-10319095|ensembl:ENSP00000356793	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804074|imex:IM-26339-102	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rigid:QUUSZp5Z2YY+Auzecz6Q8wnmN0o	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P47992	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804062|imex:IM-26339-358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:8qnAk6GKKXYSyfYoqIkhNUxp9Uk	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P13501	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804050|imex:IM-26339-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:q1vILG2yoFp6Ne6ns/jcesDeXtg	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P13501	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804038|imex:IM-26339-444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:L7H0kKrbyZ19rE9lSclyNNSHypU	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P13501	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804026|imex:IM-26339-442	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:PaEveAT310P727FTY7bRaqaTaFE	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O00175	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804014|imex:IM-26339-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rigid:4o2q9hrOzzDQEfwqnZZUjJB8Y20	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O00585	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803954|imex:IM-26339-502	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:+yESsFWmf/B3vA4bZaSScHxg1AU	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P78556	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803942|imex:IM-26339-180	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:w/eIFBfBgs7WdgetAD0fHdo7MUQ	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q92583	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803929|imex:IM-26339-260	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:10.0x10^-9 ~1.0(molar)	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O15467	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-12204739|ensembl:ENSP00000478024|ensembl:ENSP00000482168|uniprotkb:Q4KKU0	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl16_human(display_long)|uniprotkb:CCL16(gene name)|psi-mi:CCL16(display_short)|uniprotkb:Chemokine CC-4(gene name synonym)|uniprotkb:Chemokine LEC(gene name synonym)|uniprotkb:IL-10-inducible chemokine(gene name synonym)|uniprotkb:ILINCK(gene name synonym)|uniprotkb:LCC-1(gene name synonym)|uniprotkb:Liver-expressed chemokine(gene name synonym)|uniprotkb:Lymphocyte and monocyte chemoattractant(gene name synonym)|uniprotkb:Monotactin-1(gene name synonym)|uniprotkb:NCC-4(gene name synonym)|uniprotkb:NCC4(gene name synonym)|uniprotkb:SCYA16(gene name synonym)|uniprotkb:Small-inducible cytokine A16(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803917|imex:IM-26339-500	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000275095(gene)|ensembl:ENSG00000275152(gene)|ensembl:ENST00000611905(transcript)|ensembl:ENST00000621559(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007154"(cell communication)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5LTL|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_004581.1|refseq:XP_005258077.1|dip:DIP-5831N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:6CFRCcSafRw00Oj12AMaxNZBReE9606	rigid:0BNWAR6MSbbGKyuZS3HWoLLgjdU	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q99616	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803905|imex:IM-26339-440	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:3Rcn8S1kW2OsW4I/SJQ77gyvBp4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P51671	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803892|imex:IM-26339-178	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:51.0x10^-9 ~11.0(molar)	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:Ynyj0YOttBhJFFjKvO0e/fgOeFc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-16803877	uniprotkb:P80075	intact:P13501	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:ccl5(display_short)|psi-mi:EBI-16803877(display_long)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803880|imex:IM-26339-258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	-	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	-	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P13501	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16803818|imex:IM-26339-498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:CkDh27TGjX70BEcCIdGR44Q9kZ0	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P13501	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804148|imex:IM-26339-106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-9 ~2.0(molar)	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:b9DbBGpAUwUZUkpFZUR7EXmxvso	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P13501	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804499|imex:IM-26339-446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Fig. 1 D, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:298.0x10^-9 ~119.0(molar)	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:eF3gaFgLIrlAzPQ4g7r1m+1XxYA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:Q6UXB2	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804487|imex:IM-26339-600	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:JUHzt62HqSNYNOnXWnH9TwfSI4k	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:O95715	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804475|imex:IM-26339-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:0jsv1dS+sJ8x/cfuTqiKjx+ih3g	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P48061	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804462|imex:IM-26339-382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Fig. 1 C, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:35.0x10^-9 ~9.0(molar)	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:m+OcZO6ffv3+aJkNRLesGjzN/YM	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:O14625	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804450|imex:IM-26339-380	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:9WRbr58Tp1GgLCX5i7QKGUhhaVY	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P02776	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804438|imex:IM-26339-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:vJTSknH+SYR1xj14oYcRTsguUNg	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:Q07325	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804426|imex:IM-26339-110	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:MxDeUSQrLIOZ4fJ292snNDOHxjg	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P10145	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804413|imex:IM-26339-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	-	-	-	figure legend:Fig. 1 C, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:105.0x10^-9 ~11.0(molar)	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	rigid:vYCyuBKnzBqUBi3vBOZj6VtF4nw	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P80162	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804401|imex:IM-26339-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:E0LbJwSddX8d2o2mw2nAkr9IF+k	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P02776	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804389|imex:IM-26339-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:1twh5KkieaKygdXP0aHq+noaz6k	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P19875	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804377|imex:IM-26339-522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:ToIM48jHOXOzLCze6vehzgzb3Co	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P19875	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804365|imex:IM-26339-378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:ToIM48jHOXOzLCze6vehzgzb3Co	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P47992	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804353|imex:IM-26339-270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:guy9sAci/13/wrRnZEoV0C65brE	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P02776	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804341|imex:IM-26339-268	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:nqACQGK53m4HjOP5z5duhZ4oEVE	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P02776	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804329|imex:IM-26339-184	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:/PjT4CHt7NEFuZ+4W1SrOub3h0w	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P02776	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804317|imex:IM-26339-598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:a9tJp/vvYIBh3zeu8MmfZkMr4EA	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:O00585	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804305|imex:IM-26339-266	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:o+DMX1DjODOac8aCDMiRcQ9aR9g	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P78556	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804293|imex:IM-26339-590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:qPpum9DFRA2cwhBRZZKHSrns1No	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:Q92583	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804281|imex:IM-26339-588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:GAiiNVwU0OVBG07A12vxXzTJzBA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:Q99616	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804269|imex:IM-26339-520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:ETv1+DzXx1OsbOleoCC3PepQeRk	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P51671	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804257|imex:IM-26339-264	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:/R+TlvWPMJZlfVizpuh/YeW55ZA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P13501	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804244|imex:IM-26339-518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Fig. 1 C, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.0x10^-9 ~3.0(molar)	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P13500	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804232|imex:IM-26339-262	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Fig. 1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:Tg7CM/WXXYGQPLWz4Ca01d/F5PE	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q6UXB2	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804220|imex:IM-26339-586	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:jtC8ea2j5hESbCMSUGG9NrIeplc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O95715	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804186|imex:IM-26339-108	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Fig. 1 B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:U/F35ovexrhekpJYBJXkze9YqeQ	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P48061	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804173|imex:IM-26339-584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Fig. 1 B, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:578.0x10^-9 ~61.0(molar)	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:eF3gaFgLIrlAzPQ4g7r1m+1XxYA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q99616	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804524|imex:IM-26339-198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:dpAzIAZcMx5ap6YxYicemh7f3ro	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P51671	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804512|imex:IM-26339-729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:MwS/0MeUsxQXyYZIwFWqsTaq2UM	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O00585	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804591|imex:IM-26339-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:jeTDYh0CR1f2yA8c0/y49ArEjIc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O14625	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804736|imex:IM-26339-532	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:bR1x9HbUlWiH7d7H4J4QoxU6B+4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P48061	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804603|imex:IM-26339-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:ibMDqiPxrfFqzYcmd3SoodnYbiM	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:O95715	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804857|imex:IM-26339-448	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:AH2l1A/zvcRkWV8CxR5dYNchvYs	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P02776	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804845|imex:IM-26339-388	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:GAiiNVwU0OVBG07A12vxXzTJzBA	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q92583	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804833|imex:IM-26339-604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:AdXrsbtiwJufnd+GmThl58h1BbM	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q92583	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804821|imex:IM-26339-202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:Il80EPiAwtcX6yoSi/RcXg3kmZI	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:Q92583	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804809|imex:IM-26339-118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:sAI3qV9fPNTJXuXi1yz7gLeGtSU	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:O00585	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804797|imex:IM-26339-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:cL8q/Kk6D7bfg5hGU1vhKUrWGJc	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804784|imex:IM-26339-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Fig. 1 E, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:9.0x10^-9 ~2.0(molar)	2017/11/07	2018/02/26	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q6UXB2	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804772|imex:IM-26339-278	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:vSabH1+/D56eN2ZK7aXaQQ8GFW8	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O95715	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804760|imex:IM-26339-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:xEOBsCS2JfwQL77lVnYOHeJ7jA4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P48061	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804748|imex:IM-26339-276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:ICHg5lqltI2YUwo/c5PQdespqTk	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P78556	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804579|imex:IM-26339-524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:XlHh7y1dre2J0FBb38K6PPy4sTg	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P48061	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804724|imex:IM-26339-200	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:icTuLyk4hugTnSg+7exrBehl8bs	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q07325	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804712|imex:IM-26339-602	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:8xnu5JGpFY18cfEXVnWslAklFhQ	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P80162	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804700|imex:IM-26339-530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:1g0JNfRibCj3/XpdYOX8uaCOQjw	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P10720	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804688|imex:IM-26339-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:L1YveCJ9CmoQaIyCbQs+lPlU/n4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P02776	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804675|imex:IM-26339-528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Fig. 1 D, Table S2|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:20.0x10^-9 ~7.0(molar)	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:m+OcZO6ffv3+aJkNRLesGjzN/YM	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P19875	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804663|imex:IM-26339-526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:a8gL1QpOMa5ypyBbHcoQXghM0Pk	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q9UBD3	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-10319095|ensembl:ENSP00000356793	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804651|imex:IM-26339-386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rigid:dJ8psdZeXSWqdpJE5ApkhM4SCKE	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P47992	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804639|imex:IM-26339-274	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:tQJMiJsGfyttUWbZ9nKBglgraxg	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P48061	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804627|imex:IM-26339-384	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:h4b3tCDcSWGT6Srermsnf4vo/Yw	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P48061	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804615|imex:IM-26339-272	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:i5ageBbFGQAvXzEsWUpjt/toaTs	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:Q6UXB2	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804869|imex:IM-26339-204	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	-	-	figure legend:Fig. 1 E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:WVg18rhxYPbUlNqkOzqsT4QnlWU	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P10720	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561519|imex:IM-26339-717	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Fig. 1 D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:13.0x10^-9(molar)	2017/11/07	2018/05/16	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:L1YveCJ9CmoQaIyCbQs+lPlU/n4	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02775	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805095|imex:IM-26339-290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:yOKqa9DyzZoLMUH4xUGOE5J3MwY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02776	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805086|imex:IM-26339-452	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P19875	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805077|imex:IM-26339-212	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:1ESnC17m/bTKZAsUZX1+XUbOEFw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P47992	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805068|imex:IM-26339-288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:8qnAk6GKKXYSyfYoqIkhNUxp9Uk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P13501	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805059|imex:IM-26339-540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:q1vILG2yoFp6Ne6ns/jcesDeXtg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q9Y4X3	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16744026|ensembl:ENSP00000259631	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl27_human(display_long)|uniprotkb:CCL27(gene name)|psi-mi:CCL27(display_short)|uniprotkb:CC chemokine ILC(gene name synonym)|uniprotkb:Cutaneous T-cell-attracting chemokine(gene name synonym)|uniprotkb:ESkine(gene name synonym)|uniprotkb:IL-11 R-alpha-locus chemokine(gene name synonym)|uniprotkb:ILC(gene name synonym)|uniprotkb:SCYA27(gene name synonym)|uniprotkb:Skinkine(gene name synonym)|uniprotkb:Small-inducible cytokine A27(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805050|imex:IM-26339-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000213927(gene)|ensembl:ENST00000259631(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|rcsb pdb:2KUM|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5872N|refseq:NP_006655.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ClOKbWT9TpS1V4qxfAhyoh6eCYw9606	rigid:rjKAZ4y4hbctRLBlZarmLo9N1HU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P13501	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805041|imex:IM-26339-538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:L7H0kKrbyZ19rE9lSclyNNSHypU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O00175	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805032|imex:IM-26339-606	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rigid:4o2q9hrOzzDQEfwqnZZUjJB8Y20	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O00585	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805023|imex:IM-26339-210	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:+yESsFWmf/B3vA4bZaSScHxg1AU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P78556	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805014|imex:IM-26339-286	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:w/eIFBfBgs7WdgetAD0fHdo7MUQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q92583	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805005|imex:IM-26339-536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O15467	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-12204739|ensembl:ENSP00000478024|ensembl:ENSP00000482168|uniprotkb:Q4KKU0	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl16_human(display_long)|uniprotkb:CCL16(gene name)|psi-mi:CCL16(display_short)|uniprotkb:Chemokine CC-4(gene name synonym)|uniprotkb:Chemokine LEC(gene name synonym)|uniprotkb:IL-10-inducible chemokine(gene name synonym)|uniprotkb:ILINCK(gene name synonym)|uniprotkb:LCC-1(gene name synonym)|uniprotkb:Liver-expressed chemokine(gene name synonym)|uniprotkb:Lymphocyte and monocyte chemoattractant(gene name synonym)|uniprotkb:Monotactin-1(gene name synonym)|uniprotkb:NCC-4(gene name synonym)|uniprotkb:NCC4(gene name synonym)|uniprotkb:SCYA16(gene name synonym)|uniprotkb:Small-inducible cytokine A16(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804996|imex:IM-26339-284	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000275095(gene)|ensembl:ENSG00000275152(gene)|ensembl:ENST00000611905(transcript)|ensembl:ENST00000621559(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007154"(cell communication)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5LTL|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_004581.1|refseq:XP_005258077.1|dip:DIP-5831N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:6CFRCcSafRw00Oj12AMaxNZBReE9606	rigid:0BNWAR6MSbbGKyuZS3HWoLLgjdU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P13500	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804978|imex:IM-26339-208	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:XmSLLSeVaji6k1m/reGrBeI2RJ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P13501	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804969|imex:IM-26339-206	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:L7H0kKrbyZ19rE9lSclyNNSHypU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13500	uniprotkb:Q16663	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	intact:EBI-16804915|ensembl:ENSP00000477788|ensembl:ENSP00000484078|uniprotkb:B2RU34|uniprotkb:E1P651|uniprotkb:Q9UM74	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:ccl15_human(display_long)|uniprotkb:CCL15(gene name)|psi-mi:CCL15(display_short)|uniprotkb:MIP5(gene name synonym)|uniprotkb:NCC3(gene name synonym)|uniprotkb:SCYA15(gene name synonym)|uniprotkb:Chemokine CC-2(gene name synonym)|uniprotkb:Leukotactin-1(gene name synonym)|uniprotkb:MIP-1 delta(gene name synonym)|uniprotkb:Macrophage inflammatory protein 5(gene name synonym)|uniprotkb:Mrp-2b(gene name synonym)|uniprotkb:NCC-3(gene name synonym)|uniprotkb:Small-inducible cytokine A15(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804960|imex:IM-26339-751	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	dip:DIP-6218N|ensembl:ENSG00000275528(gene)|ensembl:ENSG00000275718(gene)|ensembl:ENST00000614050(transcript)|ensembl:ENST00000617897(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2HCC|go:"GO:0071347"(cellular response to interleukin-1)|refseq:NP_116741.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rogid:GMIePZmE8KPYs4I9KbjxDmYWlUs9606	rigid:8GcaT6Mvz0Bye0a0s1fEDgfYI50	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q99616	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16804906|imex:IM-26339-450	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:3Rcn8S1kW2OsW4I/SJQ77gyvBp4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:P13500	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805149|imex:IM-26339-124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:wch7Cl8DKIajTJXxUIR3jCnj3DE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O95715	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805140|imex:IM-26339-608	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:U/F35ovexrhekpJYBJXkze9YqeQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P48061	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805131|imex:IM-26339-214	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:eF3gaFgLIrlAzPQ4g7r1m+1XxYA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:O14625	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805122|imex:IM-26339-292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:Av2aXvYF4NdBJ3a1qXBSLwyts3A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P13501	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805113|imex:IM-26339-122	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:b9DbBGpAUwUZUkpFZUR7EXmxvso	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q07325	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805104|imex:IM-26339-120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:5nJC+3zbZFL/3RY1nuVDRH7EWYM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P80075	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805208|imex:IM-26339-294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rigid:BdpjDTM2jJW+0Et5/m8NH55H9Es	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:Q99616	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805199|imex:IM-26339-390	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:OLmmkILGW2Q1q7hNuJwoHRQ/cX8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:P51671	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805190|imex:IM-26339-454	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:Ru6lfemA97BsPAIkQOtE8iMFyV0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q92583	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805557|imex:IM-26339-134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:AdXrsbtiwJufnd+GmThl58h1BbM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:Q92583	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805548|imex:IM-26339-618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:sAI3qV9fPNTJXuXi1yz7gLeGtSU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805539|imex:IM-26339-464	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:O95715	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805530|imex:IM-26339-462	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:eiZUsO712Qjk5ZJfGmsaOKunBWg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:O14625	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805521|imex:IM-26339-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:kkLU5G0bZulVJL2iTczR6yi83bk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q99616	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805512|imex:IM-26339-310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:cwj1bU8a7FpZBDC9WNaQ8mAtNZI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:Q07325	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805503|imex:IM-26339-616	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:j1TAGRI1OI4cRBN2h8s3oHk3/NQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:P02775	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805494|imex:IM-26339-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:yJ3EARpSrlUcP1r0S1uD4gyPkWw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:P02776	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805485|imex:IM-26339-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:ETv1+DzXx1OsbOleoCC3PepQeRk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:P47992	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805476|imex:IM-26339-308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:dGMHB+XnBv6hLIbendv9MIPkoNk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q99616	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805467|imex:IM-26339-306	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:rcdThzq3fdIFsx9UpK+fpHenI+s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q99616	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805458|imex:IM-26339-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:b7UwO47PiD8lLbuIhXq1HmG5OeY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:Q99616	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805449|imex:IM-26339-304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:t7msGXYYlNrRs6KTpuDWrXSOxMA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99616	uniprotkb:P13501	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805440|imex:IM-26339-220	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:3Rcn8S1kW2OsW4I/SJQ77gyvBp4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:O95715	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805431|imex:IM-26339-132	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:cRU7hrozPfM4tY1IOqSpUMXevfM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:O14625	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805422|imex:IM-26339-460	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:6GLEpuB5V6mYzTcn7oiJDFemxMg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P51671	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805413|imex:IM-26339-130	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:NPxWE/50J7797Pc5TwwYDvZnYLI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:Q07325	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805404|imex:IM-26339-396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:ZWIthvPX7H1W6ct/CLb++Ise8Zk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P80162	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805395|imex:IM-26339-128	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:79ac+dQBlPJPTK1UYhNuUQn1T/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P42830	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805386|imex:IM-26339-614	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rigid:ydbnsQfNdbA5PjeDVBsF3+U5lmI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P02776	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805377|imex:IM-26339-458	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:/R+TlvWPMJZlfVizpuh/YeW55ZA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P19876	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-16805334|ensembl:ENSP00000296026|uniprotkb:Q4W5H9	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxcl3_human(display_long)|uniprotkb:CXCL3(gene name)|psi-mi:CXCL3(display_short)|uniprotkb:GRO3(gene name synonym)|uniprotkb:GROG(gene name synonym)|uniprotkb:SCYB3(gene name synonym)|uniprotkb:"GRO-gamma(1-73)"(gene name synonym)|uniprotkb:Growth-regulated protein gamma(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805368|imex:IM-26339-612	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	dip:DIP-5909N|ensembl:ENSG00000163734(gene)|ensembl:ENST00000296026(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002081.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:qoNrrg4N1ISNM5bo85VzOtVI9XA9606	rigid:MRacLQKDjYcWMkNeyVsQntRlyaE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P19875	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805325|imex:IM-26339-394	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:XQ9XlFjG7JAjXHm14enVUleExAk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P09341	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-2806484|uniprotkb:Q9UCR7|ensembl:ENSP00000379110	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:groa_human(display_long)|uniprotkb:GRO(gene name synonym)|uniprotkb:GRO1(gene name synonym)|uniprotkb:GROA(gene name synonym)|uniprotkb:MGSA(gene name synonym)|uniprotkb:SCYB1(gene name synonym)|uniprotkb:C-X-C motif chemokine 1(gene name synonym)|uniprotkb:"GRO-alpha(1-73)"(gene name synonym)|uniprotkb:Melanoma growth stimulatory activity(gene name synonym)|uniprotkb:Neutrophil-activating protein 3(gene name synonym)|uniprotkb:CXCL1(gene name)|psi-mi:CXCL1(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805316|imex:IM-26339-302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_001502.1|ensembl:ENSG00000163739(gene)|ensembl:ENST00000395761(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1MGS|rcsb pdb:1MSG|rcsb pdb:1MSH|rcsb pdb:1ROD|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|reactome:R-HSA-6798695|dip:DIP-5896N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:G1FjJPmJmTihQqinvYHGXwxJEkY9606	rigid:O1tFXgGP2nD7cyOizTPOMx1X4FQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P47992	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805307|imex:IM-26339-300	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:nTNnc8DNAa+/l2Q6r2pkyOb8Djs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P51671	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805298|imex:IM-26339-731	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:wCvdjbkUJGak9kmaWF+GD2aj93w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:Q16627	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-1046947|uniprotkb:Q13954|uniprotkb:E1P649|uniprotkb:E1P650|ensembl:ENSP00000481023|ensembl:ENSP00000487948	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:ccl14_human(display_long)|uniprotkb:Small-inducible cytokine A14(gene name synonym)|uniprotkb:Chemokine CC-1/CC-3(gene name synonym)|uniprotkb:"HCC-1(1-74)"(gene name synonym)|uniprotkb:NCC-2(gene name synonym)|uniprotkb:CCL14(gene name)|psi-mi:CCL14(display_short)|uniprotkb:NCC2(gene name synonym)|uniprotkb:SCYA14(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805289|imex:IM-26339-392	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_116738.1|refseq:NP_116739.1|ensembl:ENSG00000276409(gene)|ensembl:ENSG00000277236(gene)|ensembl:ENST00000618404(transcript)|ensembl:ENST00000632700(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2Q8R|rcsb pdb:2Q8T|dip:DIP-5861N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:wG5eG1+jHjl+XeXCzSQGVhyJqRA9606	rigid:KjUfuy0b+4FJoFhHHDm9kNBJc+I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:Q99616	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805280|imex:IM-26339-218	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:M+0qFAnIdMNg0zpXzj/uSbJev8c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P13501	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805271|imex:IM-26339-298	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:Ynyj0YOttBhJFFjKvO0e/fgOeFc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51671	uniprotkb:P13500	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805262|imex:IM-26339-610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:lNKZuyNcjlwYqGjx3cxkI23WIX4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:O14625	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805253|imex:IM-26339-544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:HOxNbsA67iHGtGhjexb49fmxm0E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P80075	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805244|imex:IM-26339-456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rigid:qu4yJn1lNbDiEWhXm1dpvny3jIg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:P10145	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805235|imex:IM-26339-542	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	rigid:gE3NRlp6a+Oy+iqnWJqMbtPu5ZU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:P80162	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805226|imex:IM-26339-216	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:+Lns59005/ldSZ2bY1lZjXi7E+o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80075	uniprotkb:P19875	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805217|imex:IM-26339-296	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:1vh8A26u+E/Qks5RpQHNrEO3asM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:Q07325	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805720|imex:IM-26339-54	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:qa5IXynasNNLh4JaK8rQTywJm+Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:P02775	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805711|imex:IM-26339-466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:wPhsY6fXX4oEPY+T9omavpvTwFk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:P02776	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805693|imex:IM-26339-52	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:o+DMX1DjODOac8aCDMiRcQ9aR9g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:P47992	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805684|imex:IM-26339-626	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:MB4raUPjWc0FARYPO/BXULj+w+4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:O00585	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805675|imex:IM-26339-624	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:qHWj3eYK6d1prVFu0Zu3SgRYL0M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:O00585	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805666|imex:IM-26339-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:+rqyPA1MBi0Bbl5GG97PAR6iGdQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:P55773	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-16805602|ensembl:ENSP00000481357|ensembl:ENSP00000488270|ensembl:ENSP00000484748|uniprotkb:B7ZKQ3|uniprotkb:O00174|uniprotkb:O75950|uniprotkb:Q52LD4	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:ccl23_human(display_long)|uniprotkb:CCL23(gene name)|psi-mi:CCL23(display_short)|uniprotkb:MIP3(gene name synonym)|uniprotkb:MPIF1(gene name synonym)|uniprotkb:SCYA23(gene name synonym)|uniprotkb:CK-beta-8(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 1(gene name synonym)|uniprotkb:Small-inducible cytokine A23(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805657|imex:IM-26339-314	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	ensembl:ENSG00000274736(gene)|ensembl:ENSG00000276114(gene)|ensembl:ENST00000612516(transcript)|ensembl:ENST00000615050(transcript)|ensembl:ENST00000632633(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2001264"(negative regulation of C-C chemokine binding)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1G91|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|refseq:NP_005055.3|refseq:NP_665905.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:8pchcUTh2gzfefqYXl7mE58m/i09606	rigid:UtoS6NEAKpC5NwytbvMqE6txP34	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:Q92583	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805593|imex:IM-26339-398	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:cL8q/Kk6D7bfg5hGU1vhKUrWGJc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:Q99616	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805584|imex:IM-26339-312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:t7msGXYYlNrRs6KTpuDWrXSOxMA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99731	uniprotkb:P10720	intact:EBI-11711434|uniprotkb:O00697|uniprotkb:O00736|ensembl:ENSP00000308815	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl19_human(display_long)|uniprotkb:CCL19(gene name)|psi-mi:CCL19(display_short)|uniprotkb:ELC(gene name synonym)|uniprotkb:MIP3B(gene name synonym)|uniprotkb:SCYA19(gene name synonym)|uniprotkb:Beta-chemokine exodus-3(gene name synonym)|uniprotkb:CK beta-11(gene name synonym)|uniprotkb:Epstein-Barr virus-induced molecule 1 ligand chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 beta(gene name synonym)|uniprotkb:Small-inducible cytokine A19(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805575|imex:IM-26339-622	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006265.1|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071731"(response to nitric oxide)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097029"(mature conventional dendritic cell differentiation)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2MP1|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|go:"GO:2000549"(positive regulation of dendritic cell dendrite assembly)|ensembl:ENSG00000172724(gene)|ensembl:ENST00000311925(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002408"(myeloid dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006955"(immune response)|go:"GO:0007154"(cell communication)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0006954"(inflammatory response)|dip:DIP-5857N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:R0MmyYGKReQDdTaFBus0m/rUhGc9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:NU6i43cUsUIU41rmXRHio8d0Mn0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P55774	uniprotkb:P51671	intact:EBI-711240|uniprotkb:Q53X71|ensembl:ENSP00000479955|ensembl:ENSP00000483144|ensembl:ENSP00000483347|uniprotkb:B5BUM2	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl18_human(display_long)|uniprotkb:CCL18(gene name)|psi-mi:CCL18(display_short)|uniprotkb:AMAC1(gene name synonym)|uniprotkb:DCCK1(gene name synonym)|uniprotkb:MIP4(gene name synonym)|uniprotkb:PARC(gene name synonym)|uniprotkb:SCYA18(gene name synonym)|uniprotkb:Dendritic cell chemokine 1(gene name synonym)|uniprotkb:Small-inducible cytokine A18(gene name synonym)|uniprotkb:Macrophage inflammatory protein 4(gene name synonym)|uniprotkb:Pulmonary and activation-regulated chemokine(gene name synonym)|uniprotkb:CC chemokine PARC(gene name synonym)|uniprotkb:Alternative macrophage activation-associated CC chemokine 1(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805566|imex:IM-26339-620	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002979.1|ensembl:ENSG00000275385(gene)|ensembl:ENSG00000278006(gene)|ensembl:ENSG00000278167(gene)|ensembl:ENST00000614828(transcript)|ensembl:ENST00000615723(transcript)|ensembl:ENST00000616054(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007154"(cell communication)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:4MHE	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kIVbD90ZDYN5T+Vwg5vb1c1UeR09606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:s03pM1lSHLPUzFxi78O+7v92ysw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:P10720	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805702|imex:IM-26339-222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:ZOjRCZBfAabiYcfnqRC62bC6l1c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q9NRJ3	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805910|imex:IM-26339-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rigid:2Io5rIbQHWvJpODyB9b79ys2YII	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:O00585	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805901|imex:IM-26339-322	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:+rqyPA1MBi0Bbl5GG97PAR6iGdQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q92583	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805892|imex:IM-26339-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:Il80EPiAwtcX6yoSi/RcXg3kmZI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q99616	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805883|imex:IM-26339-320	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:b7UwO47PiD8lLbuIhXq1HmG5OeY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P51671	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805874|imex:IM-26339-400	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:Y74Uw/l1fablRglbU0gdh+6azHs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P13501	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805865|imex:IM-26339-138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:L7H0kKrbyZ19rE9lSclyNNSHypU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P48061	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805856|imex:IM-26339-60	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:ibMDqiPxrfFqzYcmd3SoodnYbiM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P10720	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805847|imex:IM-26339-318	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:unAAoU+N+Y7FX7VpKygIeMidmvw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P02776	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805838|imex:IM-26339-58	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:a9tJp/vvYIBh3zeu8MmfZkMr4EA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P13501	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805829|imex:IM-26339-136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:PaEveAT310P727FTY7bRaqaTaFE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00175	uniprotkb:O14625	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805820|imex:IM-26339-550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:Mfx0Hmru8EibIBOtfSodpQ6z3rg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00175	uniprotkb:P47992	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805811|imex:IM-26339-228	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:ekvpKgmiyAlNewmg/XrP8ay5LRk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00175	uniprotkb:O00585	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805802|imex:IM-26339-226	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:YLhKsecevKfZX8J0JRjp3mtBVco	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00175	uniprotkb:Q99616	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805793|imex:IM-26339-628	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:HyNSiNsC0x7U66D6jA8Nlm0t4S4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00175	uniprotkb:P13501	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805784|imex:IM-26339-548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:4o2q9hrOzzDQEfwqnZZUjJB8Y20	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00626	uniprotkb:P10720	intact:EBI-3907871|uniprotkb:B2R4W2|uniprotkb:A0N0Q6|ensembl:ENSP00000219235	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl22_human(display_long)|uniprotkb:CCL22(gene name)|psi-mi:CCL22(display_short)|uniprotkb:MDC(gene name synonym)|uniprotkb:SCYA22(gene name synonym)|uniprotkb:CC chemokine STCP-1(gene name synonym)|uniprotkb:"MDC(1-69)"(gene name synonym)|uniprotkb:Macrophage-derived chemokine(gene name synonym)|uniprotkb:Small-inducible cytokine A22(gene name synonym)|uniprotkb:Stimulated T-cell chemotactic protein 1(gene name synonym)|uniprotkb:A-152E5.1(orf name)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805775|imex:IM-26339-546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002981.2|ensembl:ENSG00000102962(gene)|ensembl:ENST00000219235(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR030598|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-6783783|reactome:R-HSA-6785807|refseq:XP_016879020.1|dip:DIP-5849N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:B3l0KQM+QPLGtb/lCXyYU+rmZgI9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:nrjnNZB6xKmrymilz/1NNDrQC3o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00626	uniprotkb:Q16627	intact:EBI-3907871|uniprotkb:B2R4W2|uniprotkb:A0N0Q6|ensembl:ENSP00000219235	intact:EBI-1046947|uniprotkb:Q13954|uniprotkb:E1P649|uniprotkb:E1P650|ensembl:ENSP00000481023|ensembl:ENSP00000487948	psi-mi:ccl22_human(display_long)|uniprotkb:CCL22(gene name)|psi-mi:CCL22(display_short)|uniprotkb:MDC(gene name synonym)|uniprotkb:SCYA22(gene name synonym)|uniprotkb:CC chemokine STCP-1(gene name synonym)|uniprotkb:"MDC(1-69)"(gene name synonym)|uniprotkb:Macrophage-derived chemokine(gene name synonym)|uniprotkb:Small-inducible cytokine A22(gene name synonym)|uniprotkb:Stimulated T-cell chemotactic protein 1(gene name synonym)|uniprotkb:A-152E5.1(orf name)	psi-mi:ccl14_human(display_long)|uniprotkb:Small-inducible cytokine A14(gene name synonym)|uniprotkb:Chemokine CC-1/CC-3(gene name synonym)|uniprotkb:"HCC-1(1-74)"(gene name synonym)|uniprotkb:NCC-2(gene name synonym)|uniprotkb:CCL14(gene name)|psi-mi:CCL14(display_short)|uniprotkb:NCC2(gene name synonym)|uniprotkb:SCYA14(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805766|imex:IM-26339-316	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002981.2|ensembl:ENSG00000102962(gene)|ensembl:ENST00000219235(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR030598|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-6783783|reactome:R-HSA-6785807|refseq:XP_016879020.1|dip:DIP-5849N	refseq:NP_116738.1|refseq:NP_116739.1|ensembl:ENSG00000276409(gene)|ensembl:ENSG00000277236(gene)|ensembl:ENST00000618404(transcript)|ensembl:ENST00000632700(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2Q8R|rcsb pdb:2Q8T|dip:DIP-5861N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:B3l0KQM+QPLGtb/lCXyYU+rmZgI9606	rogid:wG5eG1+jHjl+XeXCzSQGVhyJqRA9606	rigid:kNU0xSfMZBq/+ROS0j9bNvYb4yE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00585	uniprotkb:O95715	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805757|imex:IM-26339-224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:kX4ejKkJY82qyS0T/pjK1jGoMKU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:O00585	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805748|imex:IM-26339-56	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:cZ0zadd5lpqAhZEydPtrZ1lyUHM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:P48061	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806189|imex:IM-26339-478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:tQJMiJsGfyttUWbZ9nKBglgraxg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:O14625	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806180|imex:IM-26339-476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:6xW2BXrJBglfE3VSyySagM38Zho	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:Q07325	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806171|imex:IM-26339-408	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:3Cz3EaucI04cdw9/4qiU1hacL2g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:P10720	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806162|imex:IM-26339-238	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:a9Ih/qotQDpl2Rygwa7mAIDgfmg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P47992	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806153|imex:IM-26339-326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:j2Nqh+bynT64NMn9/p0Z5pij890	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:Q99616	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806144|imex:IM-26339-146	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:dGMHB+XnBv6hLIbendv9MIPkoNk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P47992	uniprotkb:P13501	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806135|imex:IM-26339-236	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:8qnAk6GKKXYSyfYoqIkhNUxp9Uk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:O95715	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806126|imex:IM-26339-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:TtTaOXu4J7TdfIJnTdINckL4k/w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P02778	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806117|imex:IM-26339-638	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rigid:7ssa38Mqd94cpwGRrX9tHgJpdas	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P47992	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806072|imex:IM-26339-636	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:Xm1tHTVCof+A89yuWg6PzdJYAfA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q07325	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806108|imex:IM-26339-324	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:1JKrIhR+BrLXc7rYIeRgC4GRhe0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P02775	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806099|imex:IM-26339-556	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:RjuExiOqotGHCJ53NQeOxk8Nkbo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P10720	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806090|imex:IM-26339-234	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:kwRnTTAc9THHLGQlry6eE/XQ9Gs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P02776	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806081|imex:IM-26339-144	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:nqACQGK53m4HjOP5z5duhZ4oEVE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q9Y258	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806063|imex:IM-26339-554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rigid:2Io5rIbQHWvJpODyB9b79ys2YII	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:O00585	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806054|imex:IM-26339-474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:qHWj3eYK6d1prVFu0Zu3SgRYL0M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q92583	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806045|imex:IM-26339-634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:AdXrsbtiwJufnd+GmThl58h1BbM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4X3	uniprotkb:P51671	intact:EBI-16744026|ensembl:ENSP00000259631	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl27_human(display_long)|uniprotkb:CCL27(gene name)|psi-mi:CCL27(display_short)|uniprotkb:CC chemokine ILC(gene name synonym)|uniprotkb:Cutaneous T-cell-attracting chemokine(gene name synonym)|uniprotkb:ESkine(gene name synonym)|uniprotkb:IL-11 R-alpha-locus chemokine(gene name synonym)|uniprotkb:ILC(gene name synonym)|uniprotkb:SCYA27(gene name synonym)|uniprotkb:Skinkine(gene name synonym)|uniprotkb:Small-inducible cytokine A27(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806027|imex:IM-26339-472	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000213927(gene)|ensembl:ENST00000259631(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|rcsb pdb:2KUM|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5872N|refseq:NP_006655.1	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ClOKbWT9TpS1V4qxfAhyoh6eCYw9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:U44N6BxfMsqwlYJbmVwcszy2/m4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4X3	uniprotkb:P10720	intact:EBI-16744026|ensembl:ENSP00000259631	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl27_human(display_long)|uniprotkb:CCL27(gene name)|psi-mi:CCL27(display_short)|uniprotkb:CC chemokine ILC(gene name synonym)|uniprotkb:Cutaneous T-cell-attracting chemokine(gene name synonym)|uniprotkb:ESkine(gene name synonym)|uniprotkb:IL-11 R-alpha-locus chemokine(gene name synonym)|uniprotkb:ILC(gene name synonym)|uniprotkb:SCYA27(gene name synonym)|uniprotkb:Skinkine(gene name synonym)|uniprotkb:Small-inducible cytokine A27(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806009|imex:IM-26339-470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000213927(gene)|ensembl:ENST00000259631(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|rcsb pdb:2KUM|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5872N|refseq:NP_006655.1	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ClOKbWT9TpS1V4qxfAhyoh6eCYw9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:Pm0+/0fDHQs3LOazOSvNCGg/tk0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4X3	uniprotkb:P51671	intact:EBI-16744026|ensembl:ENSP00000259631	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl27_human(display_long)|uniprotkb:CCL27(gene name)|psi-mi:CCL27(display_short)|uniprotkb:CC chemokine ILC(gene name synonym)|uniprotkb:Cutaneous T-cell-attracting chemokine(gene name synonym)|uniprotkb:ESkine(gene name synonym)|uniprotkb:IL-11 R-alpha-locus chemokine(gene name synonym)|uniprotkb:ILC(gene name synonym)|uniprotkb:SCYA27(gene name synonym)|uniprotkb:Skinkine(gene name synonym)|uniprotkb:Small-inducible cytokine A27(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806000|imex:IM-26339-468	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000213927(gene)|ensembl:ENST00000259631(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|rcsb pdb:2KUM|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5872N|refseq:NP_006655.1	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ClOKbWT9TpS1V4qxfAhyoh6eCYw9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:U44N6BxfMsqwlYJbmVwcszy2/m4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y4X3	uniprotkb:P13501	intact:EBI-16744026|ensembl:ENSP00000259631	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl27_human(display_long)|uniprotkb:CCL27(gene name)|psi-mi:CCL27(display_short)|uniprotkb:CC chemokine ILC(gene name synonym)|uniprotkb:Cutaneous T-cell-attracting chemokine(gene name synonym)|uniprotkb:ESkine(gene name synonym)|uniprotkb:IL-11 R-alpha-locus chemokine(gene name synonym)|uniprotkb:ILC(gene name synonym)|uniprotkb:SCYA27(gene name synonym)|uniprotkb:Skinkine(gene name synonym)|uniprotkb:Small-inducible cytokine A27(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805991|imex:IM-26339-404	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000213927(gene)|ensembl:ENST00000259631(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|rcsb pdb:2KUM|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5872N|refseq:NP_006655.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ClOKbWT9TpS1V4qxfAhyoh6eCYw9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:rjKAZ4y4hbctRLBlZarmLo9N1HU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:O95715	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805982|imex:IM-26339-632	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:luzwbvZVDEpA/jyfn8g8tLNAJqA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:O14625	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805973|imex:IM-26339-402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:jWVUpXpmQskap4iJZWtQGs+sLHA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P02778	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805964|imex:IM-26339-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rigid:0O4dTAJ7tirOlusxgNv3AcGlz14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q07325	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805955|imex:IM-26339-142	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:4Zl+edQg2vqczMjbCB24fzMTPVA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P02775	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805946|imex:IM-26339-230	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:6vAlv3UNPFz4M88MepHWaKFlzmA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P10720	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805937|imex:IM-26339-140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:koIcm0WA06vfuOmJIzODG/cXn40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P02776	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805928|imex:IM-26339-552	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:/PjT4CHt7NEFuZ+4W1SrOub3h0w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P47992	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16805919|imex:IM-26339-630	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:j2Nqh+bynT64NMn9/p0Z5pij890	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:Q07325	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806448|imex:IM-26339-418	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:MxDeUSQrLIOZ4fJ292snNDOHxjg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P13501	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806214|imex:IM-26339-328	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:QUUSZp5Z2YY+Auzecz6Q8wnmN0o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P80098	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-718759|uniprotkb:Q569J6|ensembl:ENSP00000367832	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:ccl7_human(display_long)|uniprotkb:Small-inducible cytokine A7(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 3(gene name synonym)|uniprotkb:Monocyte chemotactic protein 3(gene name synonym)|uniprotkb:NC28(gene name synonym)|uniprotkb:CCL7(gene name)|psi-mi:CCL7(display_short)|uniprotkb:MCP3(gene name synonym)|uniprotkb:SCYA7(gene name synonym)|uniprotkb:SCYA6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806223|imex:IM-26339-480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_006264.2|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010332"(response to gamma radiation)|ensembl:ENSG00000108688(gene)|ensembl:ENST00000378569(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1BO0|rcsb pdb:1NCV|rcsb pdb:4ZKC|reactome:R-HSA-380108|dip:DIP-5847N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:xYXxbcu9VsvZbbq8sKBLe7zH0bg9606	rigid:HfpWcnBdSWCd3fhjrlnOQC4fgwc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P80075	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806232|imex:IM-26339-330	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rigid:m2eUj26lQcPzHZy1zAtEDfj+iNw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P48061	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806646|imex:IM-26339-488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:1g0JNfRibCj3/XpdYOX8uaCOQjw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P80162	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806637|imex:IM-26339-162	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:dWZ1fnDx4sm5HWW6cwJHeqDV7uM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P02776	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806628|imex:IM-26339-486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:E0LbJwSddX8d2o2mw2nAkr9IF+k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P19876	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-16805334|ensembl:ENSP00000296026|uniprotkb:Q4W5H9	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:cxcl3_human(display_long)|uniprotkb:CXCL3(gene name)|psi-mi:CXCL3(display_short)|uniprotkb:GRO3(gene name synonym)|uniprotkb:GROG(gene name synonym)|uniprotkb:SCYB3(gene name synonym)|uniprotkb:"GRO-gamma(1-73)"(gene name synonym)|uniprotkb:Growth-regulated protein gamma(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806619|imex:IM-26339-160	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	dip:DIP-5909N|ensembl:ENSG00000163734(gene)|ensembl:ENST00000296026(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002081.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:qoNrrg4N1ISNM5bo85VzOtVI9XA9606	rigid:pQfrkE2SAjE4xxgUoNDgVL+u+2U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P19875	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806610|imex:IM-26339-656	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:GNGJnPEop6vMB6ngLYjQEGXcP9A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P09341	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-2806484|uniprotkb:Q9UCR7|ensembl:ENSP00000379110	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:groa_human(display_long)|uniprotkb:GRO(gene name synonym)|uniprotkb:GRO1(gene name synonym)|uniprotkb:GROA(gene name synonym)|uniprotkb:MGSA(gene name synonym)|uniprotkb:SCYB1(gene name synonym)|uniprotkb:C-X-C motif chemokine 1(gene name synonym)|uniprotkb:"GRO-alpha(1-73)"(gene name synonym)|uniprotkb:Melanoma growth stimulatory activity(gene name synonym)|uniprotkb:Neutrophil-activating protein 3(gene name synonym)|uniprotkb:CXCL1(gene name)|psi-mi:CXCL1(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806601|imex:IM-26339-570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_001502.1|ensembl:ENSG00000163739(gene)|ensembl:ENST00000395761(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1MGS|rcsb pdb:1MSG|rcsb pdb:1MSH|rcsb pdb:1ROD|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|reactome:R-HSA-6798695|dip:DIP-5896N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:G1FjJPmJmTihQqinvYHGXwxJEkY9606	rigid:OUJDBoKbWizjLLI55qDIwppUSc0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P80098	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-718759|uniprotkb:Q569J6|ensembl:ENSP00000367832	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:ccl7_human(display_long)|uniprotkb:Small-inducible cytokine A7(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 3(gene name synonym)|uniprotkb:Monocyte chemotactic protein 3(gene name synonym)|uniprotkb:NC28(gene name synonym)|uniprotkb:CCL7(gene name)|psi-mi:CCL7(display_short)|uniprotkb:MCP3(gene name synonym)|uniprotkb:SCYA7(gene name synonym)|uniprotkb:SCYA6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806592|imex:IM-26339-654	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_006264.2|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010332"(response to gamma radiation)|ensembl:ENSG00000108688(gene)|ensembl:ENST00000378569(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1BO0|rcsb pdb:1NCV|rcsb pdb:4ZKC|reactome:R-HSA-380108|dip:DIP-5847N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:xYXxbcu9VsvZbbq8sKBLe7zH0bg9606	rigid:TbyZd5k+ZCxD0yeQhwxqT5KtrNk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P80162	uniprotkb:P13501	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806583|imex:IM-26339-346	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:/le+dwj1rYGgOd4jH4PcG3OQVyA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42830	uniprotkb:O95715	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806574|imex:IM-26339-568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:+B41iIziieF/siKFGxOxiW1PI3g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42830	uniprotkb:P19876	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	intact:EBI-16805334|ensembl:ENSP00000296026|uniprotkb:Q4W5H9	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:cxcl3_human(display_long)|uniprotkb:CXCL3(gene name)|psi-mi:CXCL3(display_short)|uniprotkb:GRO3(gene name synonym)|uniprotkb:GROG(gene name synonym)|uniprotkb:SCYB3(gene name synonym)|uniprotkb:"GRO-gamma(1-73)"(gene name synonym)|uniprotkb:Growth-regulated protein gamma(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806565|imex:IM-26339-484	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	dip:DIP-5909N|ensembl:ENSG00000163734(gene)|ensembl:ENST00000296026(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002081.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rogid:qoNrrg4N1ISNM5bo85VzOtVI9XA9606	rigid:yOaDIiV9+fF4ca1RipoXngO/y6s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42830	uniprotkb:P19875	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806556|imex:IM-26339-158	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:N1VDSOTBlMlJzApZ2chCVpoTlJs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42830	uniprotkb:P09341	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	intact:EBI-2806484|uniprotkb:Q9UCR7|ensembl:ENSP00000379110	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:groa_human(display_long)|uniprotkb:GRO(gene name synonym)|uniprotkb:GRO1(gene name synonym)|uniprotkb:GROA(gene name synonym)|uniprotkb:MGSA(gene name synonym)|uniprotkb:SCYB1(gene name synonym)|uniprotkb:C-X-C motif chemokine 1(gene name synonym)|uniprotkb:"GRO-alpha(1-73)"(gene name synonym)|uniprotkb:Melanoma growth stimulatory activity(gene name synonym)|uniprotkb:Neutrophil-activating protein 3(gene name synonym)|uniprotkb:CXCL1(gene name)|psi-mi:CXCL1(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806547|imex:IM-26339-652	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	refseq:NP_001502.1|ensembl:ENSG00000163739(gene)|ensembl:ENST00000395761(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1MGS|rcsb pdb:1MSG|rcsb pdb:1MSH|rcsb pdb:1ROD|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|reactome:R-HSA-6798695|dip:DIP-5896N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rogid:G1FjJPmJmTihQqinvYHGXwxJEkY9606	rigid:kkBUSHtaK/FcxD+6BCP2kdSnnRc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P42830	uniprotkb:P78556	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806538|imex:IM-26339-420	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:FwLfrgZ3QoKcCd94OtdfrP9TcsQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10720	uniprotkb:P48061	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806529|imex:IM-26339-566	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:L1YveCJ9CmoQaIyCbQs+lPlU/n4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10720	uniprotkb:O14625	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806520|imex:IM-26339-344	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:7sowZJijKthJ9F7AIzuhzWVkH40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10720	uniprotkb:P47992	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806511|imex:IM-26339-650	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:a9Ih/qotQDpl2Rygwa7mAIDgfmg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P10720	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806502|imex:IM-26339-342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:unAAoU+N+Y7FX7VpKygIeMidmvw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10720	uniprotkb:O00585	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806493|imex:IM-26339-340	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:ZOjRCZBfAabiYcfnqRC62bC6l1c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10720	uniprotkb:P51671	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806484|imex:IM-26339-76	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:Jjtg30IFShhpXnQ+FbEA4lftr6Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10720	uniprotkb:Q8NHW4	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	intact:EBI-10271156|uniprotkb:B7ZMA8|uniprotkb:Q50EM6|uniprotkb:Q50EM4|uniprotkb:B2RUZ3|uniprotkb:Q50EM7|uniprotkb:Q50EM5|uniprotkb:Q50EM1|uniprotkb:Q569J2|uniprotkb:Q50EM2|uniprotkb:Q50EM8|uniprotkb:Q6NSB0|uniprotkb:Q50EM3|ensembl:ENSP00000478376|ensembl:ENSP00000479126|ensembl:ENSP00000483609|ensembl:ENSP00000484322	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:cc4l_human(display_long)|uniprotkb:CCL4L1(gene name)|psi-mi:CCL4L1(display_short)|uniprotkb:CCL4L2(gene name)|psi-mi:CCL4L2(display_short)|uniprotkb:CCL4L(gene name synonym)|uniprotkb:LAG1(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:Monocyte adherence-induced protein 5-alpha(gene name synonym)|uniprotkb:SCYA4L1(gene name synonym)|uniprotkb:SCYA4L2(gene name synonym)|uniprotkb:Small-inducible cytokine A4-like(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806475|imex:IM-26339-338	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	refseq:NP_001278397.1|refseq:NP_001278398.1|refseq:NP_001278399.1|refseq:NP_001278400.1|refseq:NP_001278401.1|refseq:NP_001278402.1|refseq:NP_001278403.1|refseq:NP_001278404.1|refseq:NP_996890.1|ensembl:ENSG00000275313(gene)|ensembl:ENSG00000276070(gene)|ensembl:ENSG00000276125(gene)|ensembl:ENSG00000282604(gene)|ensembl:ENST00000613828(transcript)|ensembl:ENST00000620063(transcript)|ensembl:ENST00000620250(transcript)|ensembl:ENST00000620708(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-418594	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rogid:tXA+5IUxXDNqPgNeYzHjidViUWg9606	rigid:rbr6bkzKdJ8rtZdN33dgZKv1j2Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:O95715	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806466|imex:IM-26339-156	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:0jsv1dS+sJ8x/cfuTqiKjx+ih3g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P48061	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806457|imex:IM-26339-648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:m+OcZO6ffv3+aJkNRLesGjzN/YM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:P47992	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806205|imex:IM-26339-410	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:AFGHVjpbmJvUpyVbGiIHexC0zb0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P19875	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806439|imex:IM-26339-336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:ToIM48jHOXOzLCze6vehzgzb3Co	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P47992	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806430|imex:IM-26339-482	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:guy9sAci/13/wrRnZEoV0C65brE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P02776	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806421|imex:IM-26339-416	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:nqACQGK53m4HjOP5z5duhZ4oEVE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P02776	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806412|imex:IM-26339-154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:/PjT4CHt7NEFuZ+4W1SrOub3h0w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:P02776	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806403|imex:IM-26339-74	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:a9tJp/vvYIBh3zeu8MmfZkMr4EA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P78556	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806394|imex:IM-26339-564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:qPpum9DFRA2cwhBRZZKHSrns1No	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P13501	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806385|imex:IM-26339-414	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:9hllUnFOw5t/7klvSOn8YHbJ5EA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776	uniprotkb:P13500	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806376|imex:IM-26339-646	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:Tg7CM/WXXYGQPLWz4Ca01d/F5PE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19875	uniprotkb:Q07325	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806367|imex:IM-26339-644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:BAjMtvK71pSLLiHbEKYvPbxKS/s	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19875	uniprotkb:P47992	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806358|imex:IM-26339-334	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:spM41IrSZSBHyT71ToklfEBx2Wo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P19875	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806349|imex:IM-26339-642	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:wSrnmeAKqW0nDgXIAMcAyIRDwew	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19875	uniprotkb:O00585	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806340|imex:IM-26339-152	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:gBIDDghjJu8sUr23eIz0QXs2j2Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:Q6UXB2	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806331|imex:IM-26339-150	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:qi/ZJcwcRPPJ1pXx5T55y+SJuig	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P48061	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806322|imex:IM-26339-640	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:dJ8psdZeXSWqdpJE5ApkhM4SCKE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P42830	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-12175919|ensembl:ENSP00000296027|uniprotkb:Q96QE1	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:cxcl5_human(display_long)|uniprotkb:CXCL5(gene name)|psi-mi:CXCL5(display_short)|uniprotkb:"ENA-78(1-78)"(gene name synonym)|uniprotkb:ENA78(gene name synonym)|uniprotkb:Epithelial-derived neutrophil-activating protein 78(gene name synonym)|uniprotkb:Neutrophil-activating peptide ENA-78(gene name synonym)|uniprotkb:SCYB5(gene name synonym)|uniprotkb:Small-inducible cytokine B5(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806313|imex:IM-26339-332	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	ensembl:ENSG00000163735(gene)|ensembl:ENST00000296027(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:2MGS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002985.1|dip:DIP-5911N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:mmFRixo0vQ3KlHhtDHfVF4Na6k09606	rigid:/eSVJoE7VkFEZiQPd9Pns/LnRSA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P10720	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806304|imex:IM-26339-148	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:7JGUbLHaURe8Wprv+fZ/BGRtb28	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P02776	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806295|imex:IM-26339-562	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:hCybj1jB8tTfQG4KzZFpC4U49IQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P19876	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-16805334|ensembl:ENSP00000296026|uniprotkb:Q4W5H9	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:cxcl3_human(display_long)|uniprotkb:CXCL3(gene name)|psi-mi:CXCL3(display_short)|uniprotkb:GRO3(gene name synonym)|uniprotkb:GROG(gene name synonym)|uniprotkb:SCYB3(gene name synonym)|uniprotkb:"GRO-gamma(1-73)"(gene name synonym)|uniprotkb:Growth-regulated protein gamma(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806286|imex:IM-26339-240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	dip:DIP-5909N|ensembl:ENSG00000163734(gene)|ensembl:ENST00000296026(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002081.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:qoNrrg4N1ISNM5bo85VzOtVI9XA9606	rigid:fi+gSs1AFx1eiZJG7k7c7QyT9z0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P19875	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806277|imex:IM-26339-72	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:36olwLOW7UH5lGiDGFNeM6aPJzA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q9UBD3	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-10319095|ensembl:ENSP00000356793	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806268|imex:IM-26339-560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rigid:YXXIWO46/DRae3nywiQa/xtwWAQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q9UBD3	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-10319095|ensembl:ENSP00000356793	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806259|imex:IM-26339-412	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rigid:PDsnOU9EWgK4SQoRHKM++yJPA1I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:O00585	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806250|imex:IM-26339-558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:UQdieMUVkj5T7S2ZQIrKb2y5AfM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBD3	uniprotkb:P78556	intact:EBI-10319095|ensembl:ENSP00000356793	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:xcl2_human(display_long)|uniprotkb:XCL2(gene name)|psi-mi:XCL2(display_short)|uniprotkb:C motif chemokine 2(gene name synonym)|uniprotkb:SCYC2(gene name synonym)|uniprotkb:XC chemokine ligand 2(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806241|imex:IM-26339-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003166.1|ensembl:ENSG00000143185(gene)|ensembl:ENST00000367819(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-380108|reactome:R-HSA-416476	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:BevmcnY/+zufnr9pjjwuVogEwTc9606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:49eVirxnmAijhBWqXrVZosFynjs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02775	uniprotkb:P80075	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806662|imex:IM-26339-572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rigid:+ECZXavf6e992cO7FNrRaISuEvA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02775	uniprotkb:P80162	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	intact:EBI-9214033|uniprotkb:B2R4X3|uniprotkb:Q4W5D4|ensembl:ENSP00000226317	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:cxcl6_human(display_long)|uniprotkb:CXCL6(gene name)|psi-mi:CXCL6(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:SCYB6(gene name synonym)|uniprotkb:Chemokine alpha 3(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine B6(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806671|imex:IM-26339-422	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	refseq:NP_002984.1|ensembl:ENSG00000124875(gene)|ensembl:ENST00000226317(transcript)|go:"GO:0001776"(leukocyte homeostasis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032642"(regulation of chemokine production)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070951"(regulation of neutrophil mediated killing of gram-negative bacterium)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|reactome:R-HSA-380108|reactome:R-HSA-418594	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rogid:z0kZUQZ7yjE5mkKOlPF+AuzcQBw9606	rigid:0zeNyuZFOXA1sgy685ERqSvNhxU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02775	uniprotkb:Q07325	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806680|imex:IM-26339-164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:L4PRsX5A76+dDf6IhubZXB3pIiI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10145	uniprotkb:P13500	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806689|imex:IM-26339-166	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:W5m0JN4mS4XiJqTt97+onP/+I+w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q07325	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806725|imex:IM-26339-490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:4Zl+edQg2vqczMjbCB24fzMTPVA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07325	uniprotkb:O00585	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806716|imex:IM-26339-658	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:qa5IXynasNNLh4JaK8rQTywJm+Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07325	uniprotkb:P13500	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806707|imex:IM-26339-426	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:fj8aNzZBwg3rDw89L14NXMUn5PU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10145	uniprotkb:P02776	intact:EBI-3917999|uniprotkb:Q9UCS0|uniprotkb:Q9UCR8|uniprotkb:Q9C077|uniprotkb:Q6FGF6|uniprotkb:Q96RG6|uniprotkb:B2R4L8|uniprotkb:Q9UCE1|uniprotkb:Q9UCR9|uniprotkb:Q6LAE6|ensembl:ENSP00000306512	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:il8_human(display_long)|uniprotkb:Protein 3-10C(gene name synonym)|uniprotkb:T-cell chemotactic factor(gene name synonym)|uniprotkb:CXCL8(gene name)|psi-mi:CXCL8(display_short)|uniprotkb:C-X-C motif chemokine 8(gene name synonym)|uniprotkb:"Chemokine (C-X-C motif) ligand 8"(gene name synonym)|uniprotkb:Emoctakin(gene name synonym)|uniprotkb:Granulocyte chemotactic protein 1(gene name synonym)|uniprotkb:IL8(gene name synonym)|uniprotkb:Monocyte-derived neutrophil chemotactic factor(gene name synonym)|uniprotkb:Monocyte-derived neutrophil-activating peptide(gene name synonym)|uniprotkb:Neutrophil-activating protein 1(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806698|imex:IM-26339-424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000575.1|ensembl:ENSG00000169429(gene)|ensembl:ENST00000307407(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005153"(interleukin-8 receptor binding)|go:"GO:0005576"(extracellular region)|reactome:R-HSA-6785807|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031623"(receptor internalization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042119"(neutrophil activation)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045091"(regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0006935"(chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000535"(regulation of entry of bacterium into host cell)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR028469|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1ICW|rcsb pdb:1IKL|rcsb pdb:1IKM|rcsb pdb:1IL8|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|rcsb pdb:1ILQ|rcsb pdb:1QE6|rcsb pdb:1ROD|rcsb pdb:2IL8|rcsb pdb:3IL8|rcsb pdb:4XDX|rcsb pdb:5D14|rcsb pdb:5WDZ|rcsb pdb:6LFM|rcsb pdb:6LFO|rcsb pdb:6N2U|rcsb pdb:6WZM|reactome:R-HSA-2559582|reactome:R-HSA-375276|rcsb pdb:1ILP|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-3778N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:aC4GQA1hEtGxhjdfmoeStVe8Mf09606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:vYCyuBKnzBqUBi3vBOZj6VtF4nw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07325	uniprotkb:P02776	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806734|imex:IM-26339-574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:MxDeUSQrLIOZ4fJ292snNDOHxjg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q07325	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807145|imex:IM-26339-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:8xnu5JGpFY18cfEXVnWslAklFhQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P02775	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807136|imex:IM-26339-250	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:g+FmKlfwyVExdjpx8ZKucyVCvy4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P10720	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807127|imex:IM-26339-596	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:L1YveCJ9CmoQaIyCbQs+lPlU/n4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P02776	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807118|imex:IM-26339-510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:m+OcZO6ffv3+aJkNRLesGjzN/YM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P19875	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807109|imex:IM-26339-430	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:a8gL1QpOMa5ypyBbHcoQXghM0Pk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P48061	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807100|imex:IM-26339-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:h4b3tCDcSWGT6Srermsnf4vo/Yw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P48061	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807091|imex:IM-26339-356	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:i5ageBbFGQAvXzEsWUpjt/toaTs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O00585	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807082|imex:IM-26339-248	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:jeTDYh0CR1f2yA8c0/y49ArEjIc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P78556	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807073|imex:IM-26339-246	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:XlHh7y1dre2J0FBb38K6PPy4sTg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q99616	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807064|imex:IM-26339-666	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:dpAzIAZcMx5ap6YxYicemh7f3ro	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P51671	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807055|imex:IM-26339-192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:MwS/0MeUsxQXyYZIwFWqsTaq2UM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:P13501	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807046|imex:IM-26339-594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:eF3gaFgLIrlAzPQ4g7r1m+1XxYA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:O95715	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807037|imex:IM-26339-508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:LrO84sWHIk/+5R5AvtI67lzHDjs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P48061	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807028|imex:IM-26339-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:bR1x9HbUlWiH7d7H4J4QoxU6B+4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:O14625	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807019|imex:IM-26339-190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:8cxpRGCDgS6HvAlAWWptwmaLXuI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:Q07325	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807010|imex:IM-26339-188	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:LrHtf27x/m3wm4bHNKpaXGpY2L4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P02775	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807001|imex:IM-26339-506	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:7ruk5yXhDJ0xwAmhx+3p94TgUTw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P10720	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806992|imex:IM-26339-592	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:7sowZJijKthJ9F7AIzuhzWVkH40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P02776	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806983|imex:IM-26339-504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:9WRbr58Tp1GgLCX5i7QKGUhhaVY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P19875	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806974|imex:IM-26339-576	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:CJywOoKaFYdOmexxBEc6O1lLwgY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:O14625	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806965|imex:IM-26339-664	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:jWVUpXpmQskap4iJZWtQGs+sLHA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:O14625	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806956|imex:IM-26339-354	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:h+8oRwIiSeOUxqpkLNMPBZ9DtmY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:O00175	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-16803966|ensembl:ENSP00000222902|ensembl:ENSP00000400533|uniprotkb:B2R5K2	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:ccl24_human(display_long)|uniprotkb:CCL24(gene name)|psi-mi:CCL24(display_short)|uniprotkb:MPIF2(gene name synonym)|uniprotkb:SCYA24(gene name synonym)|uniprotkb:CK-beta-6(gene name synonym)|uniprotkb:Eosinophil chemotactic protein 2(gene name synonym)|uniprotkb:Myeloid progenitor inhibitory factor 2(gene name synonym)|uniprotkb:Small-inducible cytokine A24(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806947|imex:IM-26339-176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	dip:DIP-5876N|ensembl:ENSG00000106178(gene)|ensembl:ENST00000222902(transcript)|ensembl:ENST00000416943(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:2000418"(positive regulation of eosinophil migration)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EIG|rcsb pdb:1EIH|refseq:NP_002982.2|refseq:XP_011514761.1|refseq:XP_011514762.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:SpZngWt5tnJzSzRjNoUdXmOrOUU9606	rigid:Mfx0Hmru8EibIBOtfSodpQ6z3rg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:O00585	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806938|imex:IM-26339-352	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:OnIVmyvgU24qCQ6bbB55yh5lFJg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P78556	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806929|imex:IM-26339-350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:yYWSWBOVtnJ+NQfDUESuHlKbq3o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:Q99616	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806920|imex:IM-26339-174	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:kkLU5G0bZulVJL2iTczR6yi83bk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14625	uniprotkb:P22362	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	intact:EBI-16806869|ensembl:ENSP00000225842|uniprotkb:B2R5G9|uniprotkb:Q2M309	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:ccl1_human(display_long)|uniprotkb:CCL1(gene name)|psi-mi:CCL1(display_short)|uniprotkb:SCYA1(gene name synonym)|uniprotkb:Small-inducible cytokine A1(gene name synonym)|uniprotkb:T lymphocyte-secreted protein I-309(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806911|imex:IM-26339-496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	dip:DIP-5835N|ensembl:ENSG00000108702(gene)|ensembl:ENST00000225842(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008009"(chemokine activity)|go:"GO:0016032"(viral process)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1EL0|rcsb pdb:4OIJ|rcsb pdb:4OIK|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_002972.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rogid:EDqNs6gvtzDVQzWUG8hXVx4TwzM9606	rigid:N2rOmoEktbrpiDTWFdmpxozIgWY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:O95715	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806860|imex:IM-26339-662	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:6NzcdVJhZrxLqU1/DeI3zjVb0Ag	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q07325	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806851|imex:IM-26339-494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:YFdsGvAAjKaADfxNgumAXtvsGx0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P02775	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806842|imex:IM-26339-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:DfJQregReDmH/chcMrxSnhXrKmU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P10720	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806833|imex:IM-26339-428	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:EWyu90BD6HN3vfxFXumvn3ACxEU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P02776	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806824|imex:IM-26339-172	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:vJTSknH+SYR1xj14oYcRTsguUNg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P47992	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806815|imex:IM-26339-348	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:xmGqkMC/UZ24L000EVdFRonra10	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q9NRJ3	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806806|imex:IM-26339-492	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rigid:7ssa38Mqd94cpwGRrX9tHgJpdas	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q9Y258	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806797|imex:IM-26339-660	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rigid:0O4dTAJ7tirOlusxgNv3AcGlz14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:O00585	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806788|imex:IM-26339-80	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:cZ0zadd5lpqAhZEydPtrZ1lyUHM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q99616	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806779|imex:IM-26339-244	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:cwj1bU8a7FpZBDC9WNaQ8mAtNZI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P51671	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806770|imex:IM-26339-170	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:NPxWE/50J7797Pc5TwwYDvZnYLI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07325	uniprotkb:O95715	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806761|imex:IM-26339-78	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:AxWpCVUrH3ug8xcbzu3Q45oNlJc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q07325	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806752|imex:IM-26339-168	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:YFdsGvAAjKaADfxNgumAXtvsGx0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q07325	uniprotkb:P02775	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16806743|imex:IM-26339-242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:L4PRsX5A76+dDf6IhubZXB3pIiI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:P48061	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807173|imex:IM-26339-252	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:icTuLyk4hugTnSg+7exrBehl8bs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O95715	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807191|imex:IM-26339-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:xEOBsCS2JfwQL77lVnYOHeJ7jA4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:Q07325	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807398|imex:IM-26339-672	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:vw9CJlJ7bh+/FS+U2RrIoRvRK0M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:O95715	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807416|imex:IM-26339-256	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:62OtJ2AyMkNQT49jhIJoXUIG/Cs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02778	uniprotkb:Q6UXB2	intact:EBI-7815386|ensembl:ENSP00000305651|uniprotkb:Q96QJ5|intact:MINT-91448	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:cxl10_human(display_long)|uniprotkb:CXCL10(gene name)|psi-mi:CXCL10(display_short)|uniprotkb:INP10(gene name synonym)|uniprotkb:SCYB10(gene name synonym)|uniprotkb:Small-inducible cytokine B10(gene name synonym)|uniprotkb:10 kDa interferon gamma-induced protein(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807407|imex:IM-26339-376	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169245(gene)|ensembl:ENST00000306602(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007517"(muscle organ development)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009409"(response to cold)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010819"(regulation of T cell chemotaxis)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033280"(response to vitamin D)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901509"(regulation of endothelial tube morphogenesis)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|go:"GO:0008201"(heparin binding)|interpro:IPR033899|interpro:IPR036048|mint:P02778|rcsb pdb:1LV9|rcsb pdb:1O7Y|rcsb pdb:1O7Z|rcsb pdb:1O80|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|refseq:NP_001556.2|dip:DIP-5893N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	comment:mint|function:Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:8Ipc4RU9aixIA9ag23IQ9qvrpwA9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:qFu2LkyBJEcQdcKbV8ZvecfYHIo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:P02776	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807389|imex:IM-26339-374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:JUHzt62HqSNYNOnXWnH9TwfSI4k	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:P47992	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-10209901|uniprotkb:Q52MA8|ensembl:ENSP00000356792	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:xcl1_human(display_long)|uniprotkb:XCL1(gene name)|psi-mi:XCL1(display_short)|uniprotkb:ATAC(gene name synonym)|uniprotkb:C motif chemokine 1(gene name synonym)|uniprotkb:Cytokine SCM-1(gene name synonym)|uniprotkb:LTN(gene name synonym)|uniprotkb:Lymphotaxin(gene name synonym)|uniprotkb:SCM-1-alpha(gene name synonym)|uniprotkb:SCYC1(gene name synonym)|uniprotkb:Small-inducible cytokine C1(gene name synonym)|uniprotkb:XC chemokine ligand 1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807380|imex:IM-26339-372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_002986.1|refseq:XP_011508167.1|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071636"(positive regulation of transforming growth factor beta production)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000412"(positive regulation of thymocyte migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|go:"GO:2000513"(positive regulation of granzyme A production)|go:"GO:2000518"(negative regulation of T-helper 1 cell activation)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000558"(positive regulation of immunoglobulin production in mucosal tissue)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000563"(positive regulation of CD4-positive, alpha-beta T cell proliferation)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR008105(Lymphotactin precursor)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1J8I|rcsb pdb:1J9O|rcsb pdb:2HDM|rcsb pdb:2JP1|rcsb pdb:2N54|rcsb pdb:2NYZ|reactome:R-HSA-380108|reactome:R-HSA-416476|ensembl:ENSG00000143184(gene)|ensembl:ENST00000367818(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0002725"(negative regulation of T cell cytokine production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0035782"(mature natural killer cell chemotaxis)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048020"(CCR chemokine receptor binding)|dip:DIP-29876N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:DRRNNQxttFRNuXdLAqzUany8MTQ9606	rigid:v6IzsfBhef11w400wM3bwHklTvM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:Q6UXB2	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807371|imex:IM-26339-670	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:NoHmtLdwkeHwTWhZl3G6/LZjm8g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:Q6UXB2	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807362|imex:IM-26339-516	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:YY87o+2+w+UVWObaULf3yH4RYMw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15444	uniprotkb:Q6UXB2	intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807353|imex:IM-26339-116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:vZ9PcPmk/eFm+74H3ULphByKfmM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:O00585	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807344|imex:IM-26339-254	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:gE7zbKKwJjl2/QzUUiVKjbqw1CY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:P78556	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-3913209|uniprotkb:Q99664|uniprotkb:Q53S51|ensembl:ENSP00000351671	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:ccl20_human(display_long)|uniprotkb:CCL20(gene name)|psi-mi:CCL20(display_short)|uniprotkb:LARC(gene name synonym)|uniprotkb:MIP3A(gene name synonym)|uniprotkb:SCYA20(gene name synonym)|uniprotkb:Beta-chemokine exodus-1(gene name synonym)|uniprotkb:CC chemokine LARC(gene name synonym)|uniprotkb:Liver and activation-regulated chemokine(gene name synonym)|uniprotkb:Macrophage inflammatory protein 3 alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A20(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807335|imex:IM-26339-370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_001123518.1|refseq:NP_004582.1|ensembl:ENSG00000115009(gene)|ensembl:ENST00000358813(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031731"(CCR6 chemokine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072678"(T cell migration)|go:"GO:0072679"(thymocyte migration)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:P78556|rcsb pdb:1M8A|rcsb pdb:2HCI|rcsb pdb:2JYO|rcsb pdb:5UR7|rcsb pdb:6WWZ|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|dip:DIP-5864N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:ZOPQjamFqp/TxK/9rE4YVOUdKEE9606	rigid:kePQFvNx09obCOymjZkmUYvBzkg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:Q99616	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-725342|uniprotkb:O95689|uniprotkb:Q6ICQ6|ensembl:ENSP00000225844	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:ccl13_human(display_long)|uniprotkb:Small-inducible cytokine A13(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 4(gene name synonym)|uniprotkb:Monocyte chemotactic protein 4(gene name synonym)|uniprotkb:CK-beta-10(gene name synonym)|uniprotkb:NCC-1(gene name synonym)|uniprotkb:CCL13(gene name)|psi-mi:CCL13(display_short)|uniprotkb:MCP4(gene name synonym)|uniprotkb:NCC1(gene name synonym)|uniprotkb:SCYA13(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807326|imex:IM-26339-196	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_005399.1|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|ensembl:ENSG00000181374(gene)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|ensembl:ENST00000225844(transcript)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0005615"(extracellular space)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0006935"(chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:2RA4|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5874N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:XWQqICivGHM/r6V45d+SXJ4WAQE9606	rigid:5yqt4UqYBWHL4gFFLTc4P8rFTGE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:P80075	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807317|imex:IM-26339-753	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rigid:atuQxpeGqsrIfNrgGtGZDoTwaaM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:P13501	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807308|imex:IM-26339-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:jtC8ea2j5hESbCMSUGG9NrIeplc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UXB2	uniprotkb:P13500	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807299|imex:IM-26339-514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:dsend6KTq3plybPxxg+OO82/IPA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:O14625	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807290|imex:IM-26339-512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:LrO84sWHIk/+5R5AvtI67lzHDjs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:Q07325	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-3911467|uniprotkb:Q503B4|ensembl:ENSP00000354901	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:cxcl9_human(display_long)|uniprotkb:CXCL9(gene name)|psi-mi:CXCL9(display_short)|uniprotkb:CMK(gene name synonym)|uniprotkb:MIG(gene name synonym)|uniprotkb:SCYB9(gene name synonym)|uniprotkb:Gamma-interferon-induced monokine(gene name synonym)|uniprotkb:Monokine induced by interferon-gamma(gene name synonym)|uniprotkb:Small-inducible cytokine B9(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807281|imex:IM-26339-194	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_002407.1|ensembl:ENSG00000138755(gene)|ensembl:ENST00000264888(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051607"(defense response to virus)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1901741"(positive regulation of myoblast fusion)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q07325|reactome:R-HSA-380108|reactome:R-HSA-418594|dip:DIP-5892N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:ujBZxle2V/iOO2SJRfu5bNNAM3Y9606	rigid:AxWpCVUrH3ug8xcbzu3Q45oNlJc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:P02775	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-718973|intact:EBI-2844970|uniprotkb:Q6IBJ8|uniprotkb:B2R5F3|ensembl:ENSP00000296028	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:cxcl7_human(display_long)|uniprotkb:Small-inducible cytokine B7(gene name synonym)|uniprotkb:Leukocyte-derived growth factor(gene name synonym)|uniprotkb:Macrophage-derived growth factor(gene name synonym)|uniprotkb:CXCL7(gene name synonym)|uniprotkb:C-X-C motif chemokine 7(gene name synonym)|uniprotkb:PPBP(gene name)|psi-mi:PPBP(display_short)|uniprotkb:CTAP3(gene name synonym)|uniprotkb:SCYB7(gene name synonym)|uniprotkb:TGB1(gene name synonym)|uniprotkb:THBGB1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807272|imex:IM-26339-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_002695.1|ensembl:ENSG00000163736(gene)|ensembl:ENST00000296028(transcript)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904659"(glucose transmembrane transport)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:1F9P|rcsb pdb:1NAP|rcsb pdb:1TVX|reactome:R-HSA-114608|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6798695|dip:DIP-5913N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:npmdejiChVpEgWPFZy0vRGdHcjc9606	rigid:Q8fgOTiIwZ7lN24a5QmO1DWWiXE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:P02776	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807263|imex:IM-26339-368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606	rigid:0jsv1dS+sJ8x/cfuTqiKjx+ih3g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:P19875	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-2114901|uniprotkb:Q9UPB8|uniprotkb:Q6FGD6|ensembl:ENSP00000427279	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:cxcl2_human(display_long)|uniprotkb:CXCL2(gene name)|psi-mi:CXCL2(display_short)|uniprotkb:GRO2(gene name synonym)|uniprotkb:GROB(gene name synonym)|uniprotkb:MIP2A(gene name synonym)|uniprotkb:SCYB2(gene name synonym)|uniprotkb:Macrophage inflammatory protein 2-alpha(gene name synonym)|uniprotkb:Growth-regulated protein beta(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807254|imex:IM-26339-366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	refseq:NP_002080.1|dip:DIP-5908N|ensembl:ENSG00000081041(gene)|ensembl:ENST00000508487(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P19875|rcsb pdb:1QNK|rcsb pdb:5OB5|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:fnf2JLjB9U/QnXW12tkLOTHSeVA9606	rigid:BOmAQL34lMnHiRHGatQSE+GqTb8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:O95715	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807245|imex:IM-26339-364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rigid:luzwbvZVDEpA/jyfn8g8tLNAJqA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95715	uniprotkb:O00585	intact:EBI-2798068|uniprotkb:Q9BTR1|uniprotkb:Q86U69|uniprotkb:Q6UW97|uniprotkb:B3KQU8|uniprotkb:Q9NS21|ensembl:ENSP00000337065	intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7	psi-mi:cxl14_human(display_long)|uniprotkb:MIP2G(gene name synonym)|uniprotkb:NJAC(gene name synonym)|uniprotkb:SCYB14(gene name synonym)|uniprotkb:Chemokine BRAK(gene name synonym)|uniprotkb:MIP-2G(gene name synonym)|uniprotkb:Small-inducible cytokine B14(gene name synonym)|uniprotkb:UNQ240/PRO273(orf name)|uniprotkb:PSEC0212(orf name)|uniprotkb:CXCL14(gene name)|psi-mi:CXCL14(display_short)	psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807236|imex:IM-26339-362	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-61148N|refseq:NP_004878.2|ensembl:ENSG00000145824(gene)|ensembl:ENST00000337225(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039088|mint:O95715|rcsb pdb:2HDL|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)	ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:VzzrayuCD0FYBEMcVpZY2RtWCc49606	rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606	rigid:kX4ejKkJY82qyS0T/pjK1jGoMKU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43927	uniprotkb:P10720	intact:EBI-719170|ensembl:ENSP00000507688|ensembl:ENSP00000286758	intact:EBI-1223944|uniprotkb:A1L4S0|ensembl:ENSP00000226524	psi-mi:cxl13_human(display_long)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)|uniprotkb:B cell-attracting chemokine 1(gene name synonym)|uniprotkb:CXCL13(gene name)|psi-mi:CXCL13(display_short)|uniprotkb:BCA1(gene name synonym)|uniprotkb:BLC(gene name synonym)|uniprotkb:SCYB13(gene name synonym)|uniprotkb:Angie(gene name synonym)	psi-mi:pf4v_human(display_long)|uniprotkb:PF4V1(gene name)|psi-mi:PF4V1(display_short)|uniprotkb:SCYB4V1(gene name synonym)|uniprotkb:CXCL4V1(gene name synonym)|uniprotkb:PF4var1(gene name synonym)|uniprotkb:PF4alt(gene name synonym)|uniprotkb:C-X-C motif chemokine 4 variant(gene name synonym)|uniprotkb:CXCL4L1(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807227|imex:IM-26339-434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006410.1|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:5CBA|rcsb pdb:5CBE|rcsb pdb:6VGJ|rcsb pdb:7JNY|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000286758(transcript)|ensembl:ENST00000682537(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002920"(regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|refseq:XP_006714126.1|ensembl:ENSG00000156234(gene)|dip:DIP-5914N	refseq:NP_002611.1|ensembl:ENSG00000109272(gene)|ensembl:ENST00000226524(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|rcsb pdb:4HSV|reactome:R-HSA-140875|reactome:R-HSA-202733	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:5/65nY3r+t/6Br3fQLOX+1JENJQ9606	rogid:+5n4xDTgIqLLWq+HoObH8ZHGvq89606	rigid:PNQLUmv9RggUNnpbDvbSyuywUW0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:O43927	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-719170|ensembl:ENSP00000507688|ensembl:ENSP00000286758	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:cxl13_human(display_long)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)|uniprotkb:B cell-attracting chemokine 1(gene name synonym)|uniprotkb:CXCL13(gene name)|psi-mi:CXCL13(display_short)|uniprotkb:BCA1(gene name synonym)|uniprotkb:BLC(gene name synonym)|uniprotkb:SCYB13(gene name synonym)|uniprotkb:Angie(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807218|imex:IM-26339-767	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_006410.1|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:5CBA|rcsb pdb:5CBE|rcsb pdb:6VGJ|rcsb pdb:7JNY|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000286758(transcript)|ensembl:ENST00000682537(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002920"(regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|refseq:XP_006714126.1|ensembl:ENSG00000156234(gene)|dip:DIP-5914N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:5/65nY3r+t/6Br3fQLOX+1JENJQ9606	rigid:N3sv0KTwlVWSr18ZcbKi7qiet40	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43927	uniprotkb:Q8NHW4	intact:EBI-719170|ensembl:ENSP00000507688|ensembl:ENSP00000286758	intact:EBI-10271156|uniprotkb:B7ZMA8|uniprotkb:Q50EM6|uniprotkb:Q50EM4|uniprotkb:B2RUZ3|uniprotkb:Q50EM7|uniprotkb:Q50EM5|uniprotkb:Q50EM1|uniprotkb:Q569J2|uniprotkb:Q50EM2|uniprotkb:Q50EM8|uniprotkb:Q6NSB0|uniprotkb:Q50EM3|ensembl:ENSP00000478376|ensembl:ENSP00000479126|ensembl:ENSP00000483609|ensembl:ENSP00000484322	psi-mi:cxl13_human(display_long)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)|uniprotkb:B cell-attracting chemokine 1(gene name synonym)|uniprotkb:CXCL13(gene name)|psi-mi:CXCL13(display_short)|uniprotkb:BCA1(gene name synonym)|uniprotkb:BLC(gene name synonym)|uniprotkb:SCYB13(gene name synonym)|uniprotkb:Angie(gene name synonym)	psi-mi:cc4l_human(display_long)|uniprotkb:CCL4L1(gene name)|psi-mi:CCL4L1(display_short)|uniprotkb:CCL4L2(gene name)|psi-mi:CCL4L2(display_short)|uniprotkb:CCL4L(gene name synonym)|uniprotkb:LAG1(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:Monocyte adherence-induced protein 5-alpha(gene name synonym)|uniprotkb:SCYA4L1(gene name synonym)|uniprotkb:SCYA4L2(gene name synonym)|uniprotkb:Small-inducible cytokine A4-like(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807209|imex:IM-26339-707	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006410.1|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:5CBA|rcsb pdb:5CBE|rcsb pdb:6VGJ|rcsb pdb:7JNY|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000286758(transcript)|ensembl:ENST00000682537(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002920"(regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|refseq:XP_006714126.1|ensembl:ENSG00000156234(gene)|dip:DIP-5914N	refseq:NP_001278397.1|refseq:NP_001278398.1|refseq:NP_001278399.1|refseq:NP_001278400.1|refseq:NP_001278401.1|refseq:NP_001278402.1|refseq:NP_001278403.1|refseq:NP_001278404.1|refseq:NP_996890.1|ensembl:ENSG00000275313(gene)|ensembl:ENSG00000276070(gene)|ensembl:ENSG00000276125(gene)|ensembl:ENSG00000282604(gene)|ensembl:ENST00000613828(transcript)|ensembl:ENST00000620063(transcript)|ensembl:ENST00000620250(transcript)|ensembl:ENST00000620708(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-418594	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:5/65nY3r+t/6Br3fQLOX+1JENJQ9606	rogid:tXA+5IUxXDNqPgNeYzHjidViUWg9606	rigid:O2yjrVH72XSj0KeQJsmNlUXgS6c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:Q6UXB2	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-16804198|ensembl:ENSP00000472467|uniprotkb:A8KAC0	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxl17_human(display_long)|uniprotkb:CXCL17(gene name)|psi-mi:CXCL17(display_short)|uniprotkb:VCC1(gene name synonym)|uniprotkb:Dendritic cell and monocyte chemokine-like protein(gene name synonym)|uniprotkb:VEGF coregulated chemokine 1(gene name synonym)|uniprotkb:UNQ473/PRO842(orf name)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807200|imex:IM-26339-432	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	ensembl:ENSG00000189377(gene)|ensembl:ENST00000601181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005615"(extracellular space)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0030154"(cell differentiation)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR029183|refseq:NP_940879.1	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:1+xaexAuXzXGpMs+4NSngr7zoWQ9606	rigid:vSabH1+/D56eN2ZK7aXaQQ8GFW8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P48061	uniprotkb:O14625	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	intact:EBI-2871971|uniprotkb:Q92840|uniprotkb:Q53YA3|ensembl:ENSP00000306884|ensembl:ENSP00000425819	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:cxl11_human(display_long)|uniprotkb:CXCL11(gene name)|psi-mi:CXCL11(display_short)|uniprotkb:ITAC(gene name synonym)|uniprotkb:SCYB11(gene name synonym)|uniprotkb:SCYB9B(gene name synonym)|uniprotkb:Beta-R1(gene name synonym)|uniprotkb:H174(gene name synonym)|uniprotkb:Interferon gamma-inducible protein 9(gene name synonym)|uniprotkb:Interferon-inducible T-cell alpha chemoattractant(gene name synonym)|uniprotkb:Small-inducible cytokine B11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16807182|imex:IM-26339-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	refseq:NP_005400.1|refseq:NP_001289052.1|ensembl:ENSG00000169248(gene)|ensembl:ENST00000306621(transcript)|ensembl:ENST00000503860(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027221|interpro:IPR033899|interpro:IPR036048|mint:O14625|rcsb pdb:1RJT|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0071222"(cellular response to lipopolysaccharide)|dip:DIP-5890N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/02/26	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rogid:3DYEzMTBc2l94yjG2PXn2jXdWe09606	rigid:bR1x9HbUlWiH7d7H4J4QoxU6B+4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13500	uniprotkb:P80075	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	intact:EBI-16803830|ensembl:ENSP00000378118|uniprotkb:A0AV77|uniprotkb:P78388	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:ccl8_human(display_long)|uniprotkb:CCL8(gene name)|psi-mi:CCL8(display_short)|uniprotkb:MCP2(gene name synonym)|uniprotkb:SCYA10(gene name synonym)|uniprotkb:SCYA8(gene name synonym)|uniprotkb:HC14(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 2(gene name synonym)|uniprotkb:Monocyte chemotactic protein 2(gene name synonym)|uniprotkb:Small-inducible cytokine A8(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20563381|imex:IM-26339-743	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	dip:DIP-5871N|ensembl:ENSG00000108700(gene)|ensembl:ENST00000394620(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009615"(response to virus)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070664"(negative regulation of leukocyte proliferation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1ESR|refseq:NP_005614.2	-	-	-	figure legend:Table S1, Figure 1A, Figure S1i|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rogid:Py97mtjnn6E7+ndReTMhp9OPNU89606	rigid:wch7Cl8DKIajTJXxUIR3jCnj3DE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NRJ3	uniprotkb:P51671	intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7	intact:EBI-727357|uniprotkb:P50877|uniprotkb:Q92490|uniprotkb:Q92491|ensembl:ENSP00000302234	psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym)	psi-mi:ccl11_human(display_long)|uniprotkb:C-C motif chemokine 11(gene name synonym)|uniprotkb:Small-inducible cytokine A11(gene name synonym)|uniprotkb:Eosinophil chemotactic protein(gene name synonym)|uniprotkb:CCL11(gene name)|psi-mi:CCL11(display_short)|uniprotkb:SCYA11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20563391|imex:IM-26339-745	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N	refseq:NP_002977.1|ensembl:ENSG00000172156(gene)|ensembl:ENST00000305869(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007611"(learning or memory)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009314"(response to radiation)|go:"GO:0009615"(response to virus)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0035962"(response to interleukin-13)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090647"(modulation of age-related behavioral decline)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P51671|rcsb pdb:1EOT|rcsb pdb:2MPM|reactome:R-HSA-380108|reactome:R-HSA-6785807|rcsb pdb:2EOT|dip:DIP-5858N	-	function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606	rogid:hrJ3CrraYPCOD/E70l49zxtIbCI9606	rigid:wCvdjbkUJGak9kmaWF+GD2aj93w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43927	uniprotkb:P13500	intact:EBI-719170|ensembl:ENSP00000507688|ensembl:ENSP00000286758	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:cxl13_human(display_long)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym)|uniprotkb:B cell-attracting chemokine 1(gene name synonym)|uniprotkb:CXCL13(gene name)|psi-mi:CXCL13(display_short)|uniprotkb:BCA1(gene name synonym)|uniprotkb:BLC(gene name synonym)|uniprotkb:SCYB13(gene name synonym)|uniprotkb:Angie(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20563456|imex:IM-26339-765	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006410.1|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|rcsb pdb:5CBA|rcsb pdb:5CBE|rcsb pdb:6VGJ|rcsb pdb:7JNY|reactome:R-HSA-380108|reactome:R-HSA-418594|ensembl:ENST00000286758(transcript)|ensembl:ENST00000682537(transcript)|go:"GO:0002467"(germinal center formation)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002920"(regulation of humoral immune response)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|refseq:XP_006714126.1|ensembl:ENSG00000156234(gene)|dip:DIP-5914N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:5/65nY3r+t/6Br3fQLOX+1JENJQ9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:HeLrAwiu1AVlUXobsoS6AokisRU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y258	uniprotkb:P13500	intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20563647|imex:IM-26339-723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:HJRIUTpJj1HPJNEM2KHQ6scD7Y4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NHW4	uniprotkb:P13500	intact:EBI-10271156|uniprotkb:B7ZMA8|uniprotkb:Q50EM6|uniprotkb:Q50EM4|uniprotkb:B2RUZ3|uniprotkb:Q50EM7|uniprotkb:Q50EM5|uniprotkb:Q50EM1|uniprotkb:Q569J2|uniprotkb:Q50EM2|uniprotkb:Q50EM8|uniprotkb:Q6NSB0|uniprotkb:Q50EM3|ensembl:ENSP00000478376|ensembl:ENSP00000479126|ensembl:ENSP00000483609|ensembl:ENSP00000484322	intact:EBI-1034732|uniprotkb:Q9UDF3|uniprotkb:B2R4V3|ensembl:ENSP00000225831	psi-mi:cc4l_human(display_long)|uniprotkb:CCL4L1(gene name)|psi-mi:CCL4L1(display_short)|uniprotkb:CCL4L2(gene name)|psi-mi:CCL4L2(display_short)|uniprotkb:CCL4L(gene name synonym)|uniprotkb:LAG1(gene name synonym)|uniprotkb:Lymphocyte activation gene 1 protein(gene name synonym)|uniprotkb:Macrophage inflammatory protein 1-beta(gene name synonym)|uniprotkb:Monocyte adherence-induced protein 5-alpha(gene name synonym)|uniprotkb:SCYA4L1(gene name synonym)|uniprotkb:SCYA4L2(gene name synonym)|uniprotkb:Small-inducible cytokine A4-like(gene name synonym)	psi-mi:ccl2_human(display_long)|uniprotkb:CCL2(gene name)|psi-mi:CCL2(display_short)|uniprotkb:MCP1(gene name synonym)|uniprotkb:SCYA2(gene name synonym)|uniprotkb:Small-inducible cytokine A2(gene name synonym)|uniprotkb:Monocyte chemoattractant protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic protein 1(gene name synonym)|uniprotkb:Monocyte chemotactic and activating factor(gene name synonym)|uniprotkb:Monocyte secretory protein JE(gene name synonym)|uniprotkb:HC11(gene name synonym)	psi-mi:"MI:0049"(filter binding)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20563926|imex:IM-26339-725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278397.1|refseq:NP_001278398.1|refseq:NP_001278399.1|refseq:NP_001278400.1|refseq:NP_001278401.1|refseq:NP_001278402.1|refseq:NP_001278403.1|refseq:NP_001278404.1|refseq:NP_996890.1|ensembl:ENSG00000275313(gene)|ensembl:ENSG00000276070(gene)|ensembl:ENSG00000276125(gene)|ensembl:ENSG00000282604(gene)|ensembl:ENST00000613828(transcript)|ensembl:ENST00000620063(transcript)|ensembl:ENST00000620250(transcript)|ensembl:ENST00000620708(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-HSA-418594	refseq:NP_002973.1|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENSG00000108691(gene)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008009"(chemokine activity)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0019079"(viral genome replication)|go:"GO:0019221"(cytokine-mediated signaling pathway)|ensembl:ENST00000225831(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0001525"(angiogenesis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031727"(CCR2 chemokine receptor binding)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035684"(helper T cell extravasation)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1904783"(positive regulation of NMDA glutamate receptor activity)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|go:"GO:2000427"(positive regulation of apoptotic cell clearance)|go:"GO:2000502"(negative regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:1DOK|rcsb pdb:1DOL|rcsb pdb:1DOM|rcsb pdb:1DON|rcsb pdb:1MCA|rcsb pdb:1ML0|rcsb pdb:2BDN|rcsb pdb:2NZ1|rcsb pdb:3IFD|rcsb pdb:4DN4|rcsb pdb:4R8I|rcsb pdb:4ZK9|reactome:R-HSA-380108|reactome:R-HSA-380994|reactome:R-HSA-6783783|reactome:R-HSA-6785807|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|dip:DIP-5838N	-	-	-	figure legend:Table S1, Figure 1A, Figure S1|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/22	rogid:tXA+5IUxXDNqPgNeYzHjidViUWg9606	rogid:kTgp2hLPu6zjT9c5jVsQDXFuR/A9606	rigid:grA8DSFg3a91lGOweJZWMggHjgY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501-PRO_0000005175	uniprotkb:P02776-PRO_0000351217	intact:EBI-11712923	intact:EBI-20561364	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:p02776-pro_0000351217(display_long)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Iroplact(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16815497|imex:IM-26339-769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2848366(chain-parent)	intact:EBI-2565740(chain-parent)	-	chain-seq-start:24|chain-seq-end:91	chain-seq-start:48|chain-seq-end:101	figure legend:Figure 2A+C+E, S3A, S4A+B+E+F+G+H, S5|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rogid:8FKs98wULNJak32nSZKkbTNRSNY9606	rigid:x/2tMh0FnGrZNIkTz/TvzENxQjg	false	mutation:66-66|15n label:?-?	mutation decreasing interaction strength:50-50	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501-PRO_0000005175	uniprotkb:P48061	intact:EBI-11712923	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16815522|imex:IM-26339-771	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2848366(chain-parent)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	chain-seq-start:24|chain-seq-end:91	-	figure legend:Figure S7A+B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:ZzlNfRSdVJ+8wbKSufR6Rz5CuZc	false	mutation:66-66	15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501-PRO_0000005175	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-11712923	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-16815583|imex:IM-26339-709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:Figure 2B+D+F, S3B, S4C+D, S6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:0ByL812vy/YPA6ntDfSlAx/OBJE	false	-	mutation:66-66|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:Q92583	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20218422|imex:IM-26339-757	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Figure S10|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	mutation:73-73,57-57|sufficient binding region:56-75	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P02776-PRO_0000351217	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-20561364	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:p02776-pro_0000351217(display_long)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Iroplact(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20218468|imex:IM-26339-735	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	intact:EBI-2565740(chain-parent)	-	-	chain-seq-start:48|chain-seq-end:101	figure legend:Figure S9|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:8FKs98wULNJak32nSZKkbTNRSNY9606	rigid:3uD8mCTzOIa7wZNQWdfPffP7oEQ	false	sufficient binding region:48-67|mutation:65-65	mutation decreasing interaction strength:50-50	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:P13501-PRO_0000005175	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-11712923	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20218468|imex:IM-26339-735	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:Figure S9|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:3uD8mCTzOIa7wZNQWdfPffP7oEQ	false	sufficient binding region:48-67|mutation:65-65	mutation:66-66|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501-PRO_0000005175	uniprotkb:P48061	intact:EBI-11712923	intact:EBI-3913254|uniprotkb:H7BYN8|uniprotkb:B2R4G0|uniprotkb:Q9H554|uniprotkb:E7EVL0|uniprotkb:Q5IT36|uniprotkb:Q2L985|uniprotkb:Q2L986|uniprotkb:Q2L988|uniprotkb:Q6ICW0|ensembl:ENSP00000363551	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:sdf1_human(display_long)|uniprotkb:CXCL12(gene name)|psi-mi:CXCL12(display_short)|uniprotkb:SDF1(gene name synonym)|uniprotkb:SDF1A(gene name synonym)|uniprotkb:SDF1B(gene name synonym)|uniprotkb:C-X-C motif chemokine 12(gene name synonym)|uniprotkb:Intercrine reduced in hepatomas(gene name synonym)|uniprotkb:Pre-B cell growth-stimulating factor(gene name synonym)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20218498|imex:IM-26339-737	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2848366(chain-parent)	refseq:NP_000600.1|refseq:NP_001029058.1|refseq:NP_954637.1|refseq:NP_001171605.1|refseq:NP_001264919.1|ensembl:ENSG00000107562(gene)|ensembl:ENST00000374429(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006952"(defense response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008009"(chemokine activity)|go:"GO:0008015"(blood circulation)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008083"(growth factor activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009314"(response to radiation)|go:"GO:0009408"(response to heat)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0033603"(positive regulation of dopamine secretion)|go:"GO:0033622"(integrin activation)|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0005576"(extracellular region)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990478"(response to ultrasound)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR033899|interpro:IPR036048|interpro:IPR039813|rcsb pdb:1A15|rcsb pdb:1QG7|rcsb pdb:1SDF|rcsb pdb:1VMC|rcsb pdb:2K01|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2KEC|rcsb pdb:2J7Z|rcsb pdb:2KED|rcsb pdb:2KEE|rcsb pdb:2KOL|rcsb pdb:2N55|rcsb pdb:2NWG|rcsb pdb:2SDF|rcsb pdb:3GV3|rcsb pdb:3HP3|rcsb pdb:4LMQ|rcsb pdb:4UAI|rcsb pdb:6SHR|reactome:R-HSA-1251985|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-9018519|dip:DIP-391N	-	chain-seq-start:24|chain-seq-end:91	-	figure legend:Figure S7C+D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/16	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rogid:DHGsB0zBMh/qkZCgG/n4mAVkfto9606	rigid:ZzlNfRSdVJ+8wbKSufR6Rz5CuZc	false	mutation:66-66|15n label:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561680|imex:IM-26339-721	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Figure S11|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:fjzeEj5lshN457yLGOd300gqUFU	false	-	mutation:73-73,57-57|sufficient binding region:56-75	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92583	uniprotkb:P13501-PRO_0000005175	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-11712923	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561680|imex:IM-26339-721	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	intact:EBI-2848366(chain-parent)	-	-	chain-seq-start:24|chain-seq-end:91	figure legend:Figure S11|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:fjzeEj5lshN457yLGOd300gqUFU	false	-	mutation:66-66|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02776-PRO_0000351217	uniprotkb:P13501-PRO_0000005175	intact:EBI-20561364	intact:EBI-11712923	psi-mi:p02776-pro_0000351217(display_long)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Iroplact(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)	psi-mi:p13501-pro_0000005175(display_long)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)	psi-mi:"MI:1103"(solution state nmr)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561708|imex:IM-26339-741	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2565740(chain-parent)	intact:EBI-2848366(chain-parent)	-	chain-seq-start:48|chain-seq-end:101	chain-seq-start:24|chain-seq-end:91	figure legend:Figure S9|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:8FKs98wULNJak32nSZKkbTNRSNY9606	rogid:u9kg21gHq0UCwtqoDeVlpa/Uc9E9606	rigid:x/2tMh0FnGrZNIkTz/TvzENxQjg	false	mutation decreasing interaction strength:50-50	mutation:66-66|15n label:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13501	uniprotkb:F6R5P4	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-20561031|ensembl:ENSMUSP00000034232	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20303763|imex:IM-26339-759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S16A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2017/11/07	2018/05/16	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rigid:I/p+mMo6HV5dt06pEbJn2ZSLyb4	false	sufficient binding region:23-91|mutation:23-23	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z126	uniprotkb:P13501	intact:EBI-8350471|intact:MINT-4107892|ensembl:ENSMUSP00000031320	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:plf4_mouse(display_long)|uniprotkb:Pf4(gene name)|psi-mi:Pf4(display_short)|uniprotkb:Cxcl4(gene name synonym)|uniprotkb:Scyb4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20315095|imex:IM-26339-711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064316.1|dip:DIP-61569N|ensembl:ENSMUSG00000029373(gene)|ensembl:ENSMUST00000031320(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q9Z126|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-202733|reactome:R-MMU-380108|reactome:R-MMU-418594|interpro:IPR027222	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	go:"GO:0009986"(cell surface)	comment:mint|function:Platelet factor 4, non-covalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes	-	figure legend:Fig. S16B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2017/11/07	2018/05/16	rogid:JD52RS18yY8b3TsxwpYzY0g3YSg10090	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:2yMElu1i5HUv7IkMaAPZM6d7eOE	false	-	sufficient binding region:23-91|mutation:23-23	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30882	uniprotkb:F6R5P4	intact:EBI-20314992|ensembl:ENSMUSP00000039600	intact:EBI-20561031|ensembl:ENSMUSP00000034232	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561180|imex:IM-26339-715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S16A|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2017/11/07	2018/05/16	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rigid:3LAggFUMmaccJNXbuAovDH0/M8w	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z126	uniprotkb:P30882	intact:EBI-8350471|intact:MINT-4107892|ensembl:ENSMUSP00000031320	intact:EBI-20314992|ensembl:ENSMUSP00000039600	psi-mi:plf4_mouse(display_long)|uniprotkb:Pf4(gene name)|psi-mi:Pf4(display_short)|uniprotkb:Cxcl4(gene name synonym)|uniprotkb:Scyb4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561192|imex:IM-26339-773	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064316.1|dip:DIP-61569N|ensembl:ENSMUSG00000029373(gene)|ensembl:ENSMUST00000031320(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031982"(vesicle)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:Q9Z126|reactome:R-MMU-114608|reactome:R-MMU-140875|reactome:R-MMU-202733|reactome:R-MMU-380108|reactome:R-MMU-418594|interpro:IPR027222	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	go:"GO:0009986"(cell surface)	comment:mint|function:Platelet factor 4, non-covalently bound to a proteoglycan molecule, is released during platelet aggregation. PF4 neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes	-	figure legend:Fig. S16B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-endothelium)|taxid:10090(Mus musculus)	-	2017/11/07	2018/05/16	rogid:JD52RS18yY8b3TsxwpYzY0g3YSg10090	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rigid:Th9M12J11YR9EDKwRZ+5KT9LtBY	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30882	uniprotkb:F6R5P4	intact:EBI-20314992|ensembl:ENSMUSP00000039600	intact:EBI-20561031|ensembl:ENSMUSP00000034232	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20315120|imex:IM-26339-713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S16C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-lymphnode)|taxid:10090(mouse lymph node)	-	2017/11/07	2018/05/16	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rigid:3LAggFUMmaccJNXbuAovDH0/M8w	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51682	uniprotkb:F6R5P4	intact:EBI-11170173|uniprotkb:O35313|uniprotkb:O35891|uniprotkb:P97308|uniprotkb:P97405|uniprotkb:Q3ZAZ8|uniprotkb:Q61867|ensembl:ENSMUSP00000107069	intact:EBI-20561031|ensembl:ENSMUSP00000034232	psi-mi:ccr5_mouse(display_long)|uniprotkb:MIP-1 alpha receptor(gene name synonym)|uniprotkb:Ccr5(gene name)|psi-mi:Ccr5(display_short)|uniprotkb:Cmkbr5(gene name synonym)	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20358175|imex:IM-26339-679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034047.2|ensembl:ENSMUSG00000079227(gene)|ensembl:ENSMUST00000111442(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0070997"(neuron death)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S17D|agonist:CCL5/CCL17 heterodimer|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2017/11/07	2018/05/17	rogid:MXaZLnGKM2iQrHa9iMKPyEjep0g10090	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rigid:miGbO6xK0LoV6Q84cvj6Gq/h3/s	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51682	uniprotkb:P30882	intact:EBI-11170173|uniprotkb:O35313|uniprotkb:O35891|uniprotkb:P97308|uniprotkb:P97405|uniprotkb:Q3ZAZ8|uniprotkb:Q61867|ensembl:ENSMUSP00000107069	intact:EBI-20314992|ensembl:ENSMUSP00000039600	psi-mi:ccr5_mouse(display_long)|uniprotkb:MIP-1 alpha receptor(gene name synonym)|uniprotkb:Ccr5(gene name)|psi-mi:Ccr5(display_short)|uniprotkb:Cmkbr5(gene name synonym)	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20421244|imex:IM-26339-681	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034047.2|ensembl:ENSMUSG00000079227(gene)|ensembl:ENSMUST00000111442(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0070997"(neuron death)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S17B|antagonist:CCL5/CCL17 heterodimer|antagonist:CCL17|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2017/11/07	2018/05/03	rogid:MXaZLnGKM2iQrHa9iMKPyEjep0g10090	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rigid:w5rfPlUr7gsLIzN7JHIzeqKdzQI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51680	uniprotkb:F6R5P4	intact:EBI-20426904|uniprotkb:Q14A03|ensembl:ENSMUSP00000062677|ensembl:ENSMUSP00000150002	intact:EBI-20561031|ensembl:ENSMUSP00000034232	psi-mi:ccr4_mouse(display_long)|uniprotkb:Ccr4(gene name)|psi-mi:Ccr4(display_short)|uniprotkb:Cmkbr4(gene name synonym)	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20425061|imex:IM-26339-683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034046.2|refseq:XP_006511996.1|refseq:XP_006511997.1|refseq:XP_011241235.1|ensembl:ENSMUSG00000047898(gene)|ensembl:ENSMUST00000054414(transcript)|ensembl:ENSMUST00000215425(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002507"(tolerance induction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009314"(response to radiation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002239(C-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S17A|agonist:CCL5|agonist:CCL5/CCL17 heterodimer|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2017/11/07	2018/05/17	rogid:iQpxQ/4bz1GO7afC9vCtDx7nKbA10090	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rigid:oPDHNGnj5yp0lLVU0pB8Zbw7Ymg	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51680	uniprotkb:P30882	intact:EBI-20426904|uniprotkb:Q14A03|ensembl:ENSMUSP00000062677|ensembl:ENSMUSP00000150002	intact:EBI-20314992|ensembl:ENSMUSP00000039600	psi-mi:ccr4_mouse(display_long)|uniprotkb:Ccr4(gene name)|psi-mi:Ccr4(display_short)|uniprotkb:Cmkbr4(gene name synonym)	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20429202|imex:IM-26339-685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034046.2|refseq:XP_006511996.1|refseq:XP_006511997.1|refseq:XP_011241235.1|ensembl:ENSMUSG00000047898(gene)|ensembl:ENSMUST00000054414(transcript)|ensembl:ENSMUST00000215425(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002507"(tolerance induction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009314"(response to radiation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002239(C-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. S17C|agonist:CCL5/CCL17 heterodimer|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2017/11/07	2018/05/03	rogid:iQpxQ/4bz1GO7afC9vCtDx7nKbA10090	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rigid:xgJ6Szv7101ssVhyvnxDfG2t404	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:F6R5P4	uniprotkb:P30882	intact:EBI-20561031|ensembl:ENSMUSP00000034232	intact:EBI-20314992|ensembl:ENSMUSP00000039600	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20429759|imex:IM-26339-687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 4A, 4B|agonist:CCL5/CCL17 heterodimer|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2017/11/07	2018/05/17	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rigid:3LAggFUMmaccJNXbuAovDH0/M8w	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51680	uniprotkb:P51682	intact:EBI-20426904|uniprotkb:Q14A03|ensembl:ENSMUSP00000062677|ensembl:ENSMUSP00000150002	intact:EBI-11170173|uniprotkb:O35313|uniprotkb:O35891|uniprotkb:P97308|uniprotkb:P97405|uniprotkb:Q3ZAZ8|uniprotkb:Q61867|ensembl:ENSMUSP00000107069	psi-mi:ccr4_mouse(display_long)|uniprotkb:Ccr4(gene name)|psi-mi:Ccr4(display_short)|uniprotkb:Cmkbr4(gene name synonym)	psi-mi:ccr5_mouse(display_long)|uniprotkb:MIP-1 alpha receptor(gene name synonym)|uniprotkb:Ccr5(gene name)|psi-mi:Ccr5(display_short)|uniprotkb:Cmkbr5(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20437215|imex:IM-26339-689	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034046.2|refseq:XP_006511996.1|refseq:XP_006511997.1|refseq:XP_011241235.1|ensembl:ENSMUSG00000047898(gene)|ensembl:ENSMUST00000054414(transcript)|ensembl:ENSMUST00000215425(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002507"(tolerance induction)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009314"(response to radiation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002239(C-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	refseq:NP_034047.2|ensembl:ENSMUSG00000079227(gene)|ensembl:ENSMUST00000111442(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0070997"(neuron death)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 4A, 4C|agonist:CCL5/CCL17 heterodimer|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dendritic cell)|taxid:10090(Mouse dendritic cell)	-	2017/11/07	2018/05/03	rogid:iQpxQ/4bz1GO7afC9vCtDx7nKbA10090	rogid:MXaZLnGKM2iQrHa9iMKPyEjep0g10090	rigid:l4k0o/B2SNi5zWgJ3JuHwmxxBeQ	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P13501	uniprotkb:Q92583	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20495561|imex:IM-26339-691	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 6|comment:This interaction was not seen in not in undiseased vessels or segments.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-coronary artery)|taxid:9606(human coronary artery)	-	2017/11/07	2018/05/03	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:DgC+FO6QhetJsY6X8WKkqpbWFLI	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P30882	uniprotkb:F6R5P4	intact:EBI-20314992|ensembl:ENSMUSP00000039600	intact:EBI-20561031|ensembl:ENSMUSP00000034232	psi-mi:ccl5_mouse(display_long)|uniprotkb:MuRantes(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)|uniprotkb:Ccl5(gene name)|psi-mi:Ccl5(display_short)|uniprotkb:Scya5(gene name synonym)	psi-mi:f6r5p4_mouse(display_long)|uniprotkb:Ccl17(gene name)|psi-mi:Ccl17(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561611|imex:IM-26339-719	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038681.2|ensembl:ENSMUSG00000035042(gene)|ensembl:ENSMUST00000035938(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031269"(pseudopodium assembly)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035688"(T-helper 1 cell diapedesis)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|rcsb pdb:5YAM|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)	refseq:NP_035462.2|refseq:XP_006530845.1|refseq:XP_006530846.1|refseq:XP_017168112.1|ensembl:ENSMUSG00000031780(gene)|ensembl:ENSMUST00000034232(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|reactome:R-MMU-380108	go:"GO:0009986"(cell surface)	-	-	figure legend:Fig. 6|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse_aortic_root)|taxid:10090(mouse_aortic_root)	-	2017/11/07	2018/05/17	rogid:z/x0oXunYI5DVyDL/nCQzjyYdHs10090	rogid:5gUGEDduQuNOp4rFOUFXfcgONe010090	rigid:3LAggFUMmaccJNXbuAovDH0/M8w	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q92583	uniprotkb:P51681	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561745|imex:IM-26339-692	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	-	-	-	figure legend:Fig. 4E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rigid:Gx/rd1PRcn0w9wjWbOtjTWajoL4	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92583	uniprotkb:Q92583	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561752|imex:IM-26339-694	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Fig. 4E|comment:"Binding competition assays revealed that the affinity of CCL17 for CCR4 was higher when adding CCL5 but not CXCL1, to promote heterodimer formation (Fig. 4E and fig. S17F)."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:Gx/rd1PRcn0w9wjWbOtjTWajoL4	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92583	uniprotkb:P51681	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561752|imex:IM-26339-694	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	-	-	-	figure legend:Fig. 4E|comment:"Binding competition assays revealed that the affinity of CCL17 for CCR4 was higher when adding CCL5 but not CXCL1, to promote heterodimer formation (Fig. 4E and fig. S17F)."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rigid:Gx/rd1PRcn0w9wjWbOtjTWajoL4	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92583	uniprotkb:Q92583	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561760|imex:IM-26339-696	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	-	-	figure legend:Fig. S17F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:Qva7BEYdD7mDkMe4vkoAwsGfKJU	false	-	alexa label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q92583	uniprotkb:P51679	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	intact:EBI-7847466|ensembl:ENSP00000332659|uniprotkb:Q9ULY6|intact:MINT-1525168|uniprotkb:Q9ULY7	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:ccr4_human(display_long)|uniprotkb:CCR4(gene name)|psi-mi:CCR4(display_short)|uniprotkb:CMKBR4(gene name synonym)|uniprotkb:K5-5(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561760|imex:IM-26339-696	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	ensembl:ENSG00000183813(gene)|ensembl:ENST00000330953(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002507"(tolerance induction)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009314"(response to radiation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002239(C-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51679|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR000276(GPCR, rhodopsin-like)|refseq:XP_016861176.1|refseq:NP_005499.1|dip:DIP-5848N	-	-	comment:mint|function:"High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival"	figure legend:Fig. S17F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rogid:UDA9xqLRvwP7SKzO9kkKdKsyhjc9606	rigid:Qva7BEYdD7mDkMe4vkoAwsGfKJU	false	-	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P51679	uniprotkb:Q92583	intact:EBI-7847466|ensembl:ENSP00000332659|uniprotkb:Q9ULY6|intact:MINT-1525168|uniprotkb:Q9ULY7	intact:EBI-16640146|ensembl:ENSP00000219244|ensembl:ENSP00000480147|uniprotkb:A0N0Q9|uniprotkb:Q2M287	psi-mi:ccr4_human(display_long)|uniprotkb:CCR4(gene name)|psi-mi:CCR4(display_short)|uniprotkb:CMKBR4(gene name synonym)|uniprotkb:K5-5(gene name synonym)	psi-mi:ccl17_human(display_long)|uniprotkb:CCL17(gene name)|psi-mi:CCL17(display_short)|uniprotkb:SCYA17(gene name synonym)|uniprotkb:TARC(gene name synonym)|uniprotkb:CC chemokine TARC(gene name synonym)|uniprotkb:Small-inducible cytokine A17(gene name synonym)|uniprotkb:Thymus and activation-regulated chemokine(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561769|imex:IM-26339-698	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000183813(gene)|ensembl:ENST00000330953(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002507"(tolerance induction)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009314"(response to radiation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002239(C-C chemokine receptor, type 4)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51679|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR000276(GPCR, rhodopsin-like)|refseq:XP_016861176.1|refseq:NP_005499.1|dip:DIP-5848N	ensembl:ENSG00000102970(gene)|ensembl:ENST00000219244(transcript)|ensembl:ENST00000616880(transcript)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|go:"GO:0031640"(killing of cells of another organism)|rcsb pdb:1NR2|rcsb pdb:1NR4|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|rcsb pdb:5WK3|reactome:R-HSA-380108|dip:DIP-5842N|refseq:NP_002978.1	-	comment:mint|function:"High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival"	-	figure legend:Fig. S17F|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:UDA9xqLRvwP7SKzO9kkKdKsyhjc9606	rogid:OJBqBk2dSmA78karpHr50aBQ/LA9606	rigid:Qva7BEYdD7mDkMe4vkoAwsGfKJU	false	-	alexa label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13501	uniprotkb:P13501	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561777|imex:IM-26339-700	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Fig. S18D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:VNyienZXjCt3gYr0TjU7pDv/t/Y	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13501	uniprotkb:P32246	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-608322|ensembl:ENSP00000296140|uniprotkb:Q86VA9	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccr1_human(display_long)|uniprotkb:Macrophage inflammatory protein 1-alpha receptor(gene name synonym)|uniprotkb:RANTES-R(gene name synonym)|uniprotkb:HM145(gene name synonym)|uniprotkb:LD78 receptor(gene name synonym)|uniprotkb:CCR1(gene name)|psi-mi:CCR1(display_short)|uniprotkb:CMKBR1(gene name synonym)|uniprotkb:CMKR1(gene name synonym)|uniprotkb:SCYAR1(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561777|imex:IM-26339-700	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000163823(gene)|ensembl:ENST00000296140(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0035717"("chemokine (C-C motif) ligand 7 binding")|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002236(C-C chemokine receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32246|rcsb pdb:1Y5D|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|interpro:IPR034321|refseq:NP_001286.1|dip:DIP-5832N	-	-	-	figure legend:Fig. S18D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:m8grSofEywwJfUzrRCNNjYrq6ps9606	rigid:VNyienZXjCt3gYr0TjU7pDv/t/Y	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13501	uniprotkb:P32246	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-608322|ensembl:ENSP00000296140|uniprotkb:Q86VA9	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccr1_human(display_long)|uniprotkb:Macrophage inflammatory protein 1-alpha receptor(gene name synonym)|uniprotkb:RANTES-R(gene name synonym)|uniprotkb:HM145(gene name synonym)|uniprotkb:LD78 receptor(gene name synonym)|uniprotkb:CCR1(gene name)|psi-mi:CCR1(display_short)|uniprotkb:CMKBR1(gene name synonym)|uniprotkb:CMKR1(gene name synonym)|uniprotkb:SCYAR1(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561787|imex:IM-26339-702	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	ensembl:ENSG00000163823(gene)|ensembl:ENST00000296140(transcript)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0035717"("chemokine (C-C motif) ligand 7 binding")|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002236(C-C chemokine receptor, type 1)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P32246|rcsb pdb:1Y5D|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|interpro:IPR034321|refseq:NP_001286.1|dip:DIP-5832N	-	-	-	figure legend:Fig. S18D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:m8grSofEywwJfUzrRCNNjYrq6ps9606	rigid:VNyienZXjCt3gYr0TjU7pDv/t/Y	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13501	uniprotkb:P13501	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561794|imex:IM-26339-704	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	-	-	-	figure legend:Fig. S18E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rigid:8Q//APM/3gJAWaVs5pmDtibaYnk	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13501	uniprotkb:P51681	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561794|imex:IM-26339-704	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	-	-	-	figure legend:Fig. S18E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rigid:8Q//APM/3gJAWaVs5pmDtibaYnk	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P13501	uniprotkb:P51681	intact:EBI-2848366|uniprotkb:Q0QVW8|uniprotkb:O43646|uniprotkb:Q9NYA2|uniprotkb:Q9UBG2|uniprotkb:Q9UC99|uniprotkb:Q4ZGJ1|ensembl:ENSP00000474141|ensembl:ENSP00000474412|ensembl:ENSP00000475057|ensembl:ENSP00000479894|ensembl:ENSP00000484921	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	psi-mi:ccl5_human(display_long)|uniprotkb:CCL5(gene name)|psi-mi:CCL5(display_short)|uniprotkb:D17S136E(gene name synonym)|uniprotkb:SCYA5(gene name synonym)|uniprotkb:EoCP(gene name synonym)|uniprotkb:Eosinophil chemotactic cytokine(gene name synonym)|uniprotkb:SIS-delta(gene name synonym)|uniprotkb:Small-inducible cytokine A5(gene name synonym)|uniprotkb:T cell-specific protein P228(gene name synonym)|uniprotkb:T-cell-specific protein RANTES(gene name synonym)	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:"MI:0054"(fluorescence-activated cell sorting)	von et al. (2017)	imex:IM-26339|doi:10.1126/scitranslmed.aah6650|pubmed:28381538	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-20561801|imex:IM-26339-706	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002976.2|dip:DIP-31N|ensembl:ENSG00000271503(gene)|ensembl:ENSG00000274233(gene)|ensembl:ENST00000603197(transcript)|ensembl:ENST00000605140(transcript)|ensembl:ENST00000605509(transcript)|ensembl:ENST00000613606(transcript)|ensembl:ENST00000618639(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002676"(regulation of chronic inflammatory response)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006887"(exocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0009615"(response to virus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0030298"(receptor signaling protein tyrosine kinase activator activity)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031328"(positive regulation of cellular biosynthetic process)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0031729"(CCR4 chemokine receptor binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046817"(chemokine receptor antagonist activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0070234"(positive regulation of T cell apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0098586"(cellular response to virus)|go:"GO:1901214"(regulation of neuron death)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000503"(positive regulation of natural killer cell chemotaxis)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:P13501|rcsb pdb:1B3A|rcsb pdb:1EQT|rcsb pdb:1HRJ|rcsb pdb:1RTN|rcsb pdb:1RTO|rcsb pdb:1U4L|rcsb pdb:1U4M|rcsb pdb:1U4P|rcsb pdb:1U4R|rcsb pdb:2L9H|rcsb pdb:2VXW|rcsb pdb:5CMD|rcsb pdb:5COY|go:"GO:0045070"(positive regulation of viral genome replication)|rcsb pdb:5DNF|rcsb pdb:5L2U|rcsb pdb:5UIW|rcsb pdb:6AEZ|rcsb pdb:6C6D|rcsb pdb:6FGP|rcsb pdb:6STK|rcsb pdb:7O7F|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:6LOG	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	-	-	-	figure legend:Fig. S18E|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/11/07	2018/05/17	rogid:ax9zuZGIpTIg8FnZi3cyCG+C+kQ9606	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rigid:8Q//APM/3gJAWaVs5pmDtibaYnk	false	alexa label:?-?	-	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)