#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P36873-2	uniprotkb:Q5JQC9	intact:EBI-3964623|ensembl:ENSP00000341779	intact:EBI-16628643|ensembl:ENSP00000351327|uniprotkb:A0AV85|uniprotkb:O60904|uniprotkb:O95246|uniprotkb:Q5JQD1|uniprotkb:Q5JQD2|uniprotkb:Q5JQD3	psi-mi:p36873-2(display_long)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Gamma-2(isoform synonym)|uniprotkb:PPPCC2(isoform synonym)	psi-mi:akap4_human(display_long)|uniprotkb:AKAP4(gene name)|psi-mi:AKAP4(display_short)|uniprotkb:AKAP82(gene name synonym)|uniprotkb:A-kinase anchor protein 82 kDa(gene name synonym)|uniprotkb:Major sperm fibrous sheath protein(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Silva et al. (2017)	pubmed:27913189|imex:IM-26174	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16628478|imex:IM-26174-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-356283(isoform-parent)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000340766(transcript)|uniprotkb:P36873-2(isoform-parent)	ensembl:ENSG00000147081(gene)|ensembl:ENST00000358526(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0008104"(protein localization)|go:"GO:0030018"(Z disc)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097229"(sperm end piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799|go:"GO:0097228"(sperm principal piece)|refseq:NP_003877.2|refseq:NP_647450.1	-	-	-	figure legend:Figure 4A, table 2|comment:Several previously well-characterized PPP1 interacting proteins were also identified; however these are not stated.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sperm)|taxid:9606(Homo sapiens - sperm)	-	2017/10/18	2017/11/17	rogid:zMWoSUfhkPeRJUfTO+Jb/VMVTGc9606	rogid:tJ2TkijolqOW2C5osXURLJcg0d89606	rigid:6cX0u5U8jrGjjKYsF1UK15JSq4w	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P36873-2	uniprotkb:P27348	intact:EBI-3964623|ensembl:ENSP00000341779	intact:EBI-359854|uniprotkb:Q567U5|uniprotkb:Q5TZU8|uniprotkb:Q9UP48|uniprotkb:D6W4Z5|ensembl:ENSP00000238081|ensembl:ENSP00000371267	psi-mi:p36873-2(display_long)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Gamma-2(isoform synonym)|uniprotkb:PPPCC2(isoform synonym)	psi-mi:1433t_human(display_long)|uniprotkb:YWHAQ(gene name)|psi-mi:YWHAQ(display_short)|uniprotkb:14-3-3 protein tau(gene name synonym)|uniprotkb:14-3-3 protein T-cell(gene name synonym)|uniprotkb:Protein HS1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Silva et al. (2017)	pubmed:27913189|imex:IM-26174	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16628478|imex:IM-26174-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-356283(isoform-parent)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000340766(transcript)|uniprotkb:P36873-2(isoform-parent)	refseq:NP_006817.1|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034766"(negative regulation of ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071889"(14-3-3 protein binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR042584|mint:P27348|rcsb pdb:2BTP|rcsb pdb:5IQP|rcsb pdb:6BCR|rcsb pdb:6BD2|rcsb pdb:6BQT|rcsb pdb:6KZG|rcsb pdb:6KZH|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-9614399|ensembl:ENSG00000134308(gene)|ensembl:ENST00000238081(transcript)|ensembl:ENST00000381844(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|dip:DIP-27584N	-	-	-	figure legend:Figure 4A, table 2|comment:Several previously well-characterized PPP1 interacting proteins were also identified; however these are not stated.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sperm)|taxid:9606(Homo sapiens - sperm)	-	2017/10/18	2017/11/17	rogid:zMWoSUfhkPeRJUfTO+Jb/VMVTGc9606	rogid:3I07h/wy8qcwUJqvO1RA76qnW5U9606	rigid:6cX0u5U8jrGjjKYsF1UK15JSq4w	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:Q5JQC9	uniprotkb:P36873-2	intact:EBI-16628643|ensembl:ENSP00000351327|uniprotkb:A0AV85|uniprotkb:O60904|uniprotkb:O95246|uniprotkb:Q5JQD1|uniprotkb:Q5JQD2|uniprotkb:Q5JQD3	intact:EBI-3964623|ensembl:ENSP00000341779	psi-mi:akap4_human(display_long)|uniprotkb:AKAP4(gene name)|psi-mi:AKAP4(display_short)|uniprotkb:AKAP82(gene name synonym)|uniprotkb:A-kinase anchor protein 82 kDa(gene name synonym)|uniprotkb:Major sperm fibrous sheath protein(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 4(gene name synonym)	psi-mi:p36873-2(display_long)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Gamma-2(isoform synonym)|uniprotkb:PPPCC2(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Silva et al. (2017)	pubmed:27913189|imex:IM-26174	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16628742|imex:IM-26174-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147081(gene)|ensembl:ENST00000358526(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0008104"(protein localization)|go:"GO:0030018"(Z disc)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097229"(sperm end piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799|go:"GO:0097228"(sperm principal piece)|refseq:NP_003877.2|refseq:NP_647450.1	intact:EBI-356283(isoform-parent)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000340766(transcript)|uniprotkb:P36873-2(isoform-parent)	-	-	-	figure legend:Figure 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sperm)|taxid:9606(Homo sapiens - sperm)	-	2017/10/18	2017/11/20	rogid:tJ2TkijolqOW2C5osXURLJcg0d89606	rogid:zMWoSUfhkPeRJUfTO+Jb/VMVTGc9606	rigid:InssdcnROs8+ua4cN/B3X3bo2c0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5JQC9	uniprotkb:P36873-2	intact:EBI-16628643|ensembl:ENSP00000351327|uniprotkb:A0AV85|uniprotkb:O60904|uniprotkb:O95246|uniprotkb:Q5JQD1|uniprotkb:Q5JQD2|uniprotkb:Q5JQD3	intact:EBI-3964623|ensembl:ENSP00000341779	psi-mi:akap4_human(display_long)|uniprotkb:AKAP4(gene name)|psi-mi:AKAP4(display_short)|uniprotkb:AKAP82(gene name synonym)|uniprotkb:A-kinase anchor protein 82 kDa(gene name synonym)|uniprotkb:Major sperm fibrous sheath protein(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 4(gene name synonym)	psi-mi:p36873-2(display_long)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Gamma-2(isoform synonym)|uniprotkb:PPPCC2(isoform synonym)	psi-mi:"MI:0047"(far western blotting)	Silva et al. (2017)	pubmed:27913189|imex:IM-26174	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16628757|imex:IM-26174-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147081(gene)|ensembl:ENST00000358526(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0008104"(protein localization)|go:"GO:0030018"(Z disc)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097229"(sperm end piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799|go:"GO:0097228"(sperm principal piece)|refseq:NP_003877.2|refseq:NP_647450.1	intact:EBI-356283(isoform-parent)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000340766(transcript)|uniprotkb:P36873-2(isoform-parent)	-	-	-	figure legend:Figure 4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/10/18	2017/11/20	rogid:tJ2TkijolqOW2C5osXURLJcg0d89606	rogid:zMWoSUfhkPeRJUfTO+Jb/VMVTGc9606	rigid:InssdcnROs8+ua4cN/B3X3bo2c0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5JQC9	uniprotkb:P36873-2	intact:EBI-16628643|ensembl:ENSP00000351327|uniprotkb:A0AV85|uniprotkb:O60904|uniprotkb:O95246|uniprotkb:Q5JQD1|uniprotkb:Q5JQD2|uniprotkb:Q5JQD3	intact:EBI-3964623|ensembl:ENSP00000341779	psi-mi:akap4_human(display_long)|uniprotkb:AKAP4(gene name)|psi-mi:AKAP4(display_short)|uniprotkb:AKAP82(gene name synonym)|uniprotkb:A-kinase anchor protein 82 kDa(gene name synonym)|uniprotkb:Major sperm fibrous sheath protein(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 4(gene name synonym)	psi-mi:p36873-2(display_long)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)|uniprotkb:PPP1CC(gene name)|psi-mi:PPP1CC(display_short)|uniprotkb:Gamma-2(isoform synonym)|uniprotkb:PPPCC2(isoform synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Silva et al. (2017)	pubmed:27913189|imex:IM-26174	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16628772|imex:IM-26174-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000147081(gene)|ensembl:ENST00000358526(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0007165"(signal transduction)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007338"(single fertilization)|go:"GO:0008104"(protein localization)|go:"GO:0030018"(Z disc)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0044458"(motile cilium assembly)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097229"(sperm end piece)|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR018292|interpro:IPR018459|interpro:IPR020799|go:"GO:0097228"(sperm principal piece)|refseq:NP_003877.2|refseq:NP_647450.1	intact:EBI-356283(isoform-parent)|ensembl:ENSG00000186298(gene)|ensembl:ENST00000340766(transcript)|uniprotkb:P36873-2(isoform-parent)	go:"GO:0036126"(sperm flagellum)	-	-	figure legend:Figure 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sperm)|taxid:9606(Homo sapiens - sperm)	-	2017/10/18	2017/11/20	rogid:tJ2TkijolqOW2C5osXURLJcg0d89606	rogid:zMWoSUfhkPeRJUfTO+Jb/VMVTGc9606	rigid:InssdcnROs8+ua4cN/B3X3bo2c0	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)