#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P36544	uniprotkb:P55000	intact:EBI-79333|uniprotkb:A8K7Q4|ensembl:ENSP00000303727|uniprotkb:Q15826|uniprotkb:Q96RH2|uniprotkb:Q99555|uniprotkb:Q9BXH0|uniprotkb:B4DFS0|uniprotkb:Q8IUZ4	intact:EBI-8830896|uniprotkb:Q6PUA6|uniprotkb:Q53YJ6|uniprotkb:Q92483|ensembl:ENSP00000246515	psi-mi:acha7_human(display_long)|uniprotkb:CHRNA7(gene name)|psi-mi:CHRNA7(display_short)|uniprotkb:NACHRA7(gene name synonym)	psi-mi:slur1_human(display_long)|uniprotkb:ARS(gene name synonym)|uniprotkb:ARS component B(gene name synonym)|uniprotkb:"ARS(component B)-81/S"(gene name synonym)|uniprotkb:Anti-neoplastic urinary protein(gene name synonym)|uniprotkb:SLURP1(gene name)|psi-mi:SLURP1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Lyukmanova et al. (2015)	pubmed:26905431|imex:IM-26256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14060872|imex:IM-26256-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175344(gene)|ensembl:ENST00000306901(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140059"(dendrite arborization)|refseq:NP_683709.1|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2MAW|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFM|rcsb pdb:5AFN|rcsb pdb:7EKI|rcsb pdb:7EKP|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|refseq:NP_000737.1|rcsb pdb:7EKT|go:"GO:1902004"(positive regulation of amyloid-beta formation)|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|reactome:R-HSA-629594|go:"GO:1905144"(response to acetylcholine)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1901214"(regulation of neuron death)|refseq:XP_016877373.1|refseq:NP_001177384.1|refseq:XP_005254807.1	refseq:NP_065160.1|ensembl:ENSG00000126233(gene)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0038195"(urokinase plasminogen activator signaling pathway)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0070062"(extracellular exosome)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR027103|rcsb pdb:6ZZE|rcsb pdb:6ZZF|go:"GO:0001775"(cell activation)|ensembl:ENST00000246515(transcript)	-	-	-	figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/11	2017/05/11	rogid:9wcnxJ2Eh9S6aVCvKwKSwLMJnMI9606	rogid:+h63SfLP+/w0r0UoFvZG6jinDao9606	rigid:In4gBjh+OnMRVgV8GEQSrltOyOc	false	-	sufficient binding region:23-103|mutation:22-23	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36544	uniprotkb:P55000	intact:EBI-79333|uniprotkb:A8K7Q4|ensembl:ENSP00000303727|uniprotkb:Q15826|uniprotkb:Q96RH2|uniprotkb:Q99555|uniprotkb:Q9BXH0|uniprotkb:B4DFS0|uniprotkb:Q8IUZ4	intact:EBI-8830896|uniprotkb:Q6PUA6|uniprotkb:Q53YJ6|uniprotkb:Q92483|ensembl:ENSP00000246515	psi-mi:acha7_human(display_long)|uniprotkb:CHRNA7(gene name)|psi-mi:CHRNA7(display_short)|uniprotkb:NACHRA7(gene name synonym)	psi-mi:slur1_human(display_long)|uniprotkb:ARS(gene name synonym)|uniprotkb:ARS component B(gene name synonym)|uniprotkb:"ARS(component B)-81/S"(gene name synonym)|uniprotkb:Anti-neoplastic urinary protein(gene name synonym)|uniprotkb:SLURP1(gene name)|psi-mi:SLURP1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Lyukmanova et al. (2015)	pubmed:26905431|imex:IM-26256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14973779|imex:IM-26256-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000175344(gene)|ensembl:ENST00000306901(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140059"(dendrite arborization)|refseq:NP_683709.1|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2MAW|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFM|rcsb pdb:5AFN|rcsb pdb:7EKI|rcsb pdb:7EKP|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|refseq:NP_000737.1|rcsb pdb:7EKT|go:"GO:1902004"(positive regulation of amyloid-beta formation)|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|reactome:R-HSA-629594|go:"GO:1905144"(response to acetylcholine)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1901214"(regulation of neuron death)|refseq:XP_016877373.1|refseq:NP_001177384.1|refseq:XP_005254807.1	refseq:NP_065160.1|ensembl:ENSG00000126233(gene)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030549"(acetylcholine receptor activator activity)|go:"GO:0038195"(urokinase plasminogen activator signaling pathway)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0070062"(extracellular exosome)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|interpro:IPR027103|rcsb pdb:6ZZE|rcsb pdb:6ZZF|go:"GO:0001775"(cell activation)|ensembl:ENST00000246515(transcript)	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/11	2017/05/23	rogid:9wcnxJ2Eh9S6aVCvKwKSwLMJnMI9606	rogid:+h63SfLP+/w0r0UoFvZG6jinDao9606	rigid:In4gBjh+OnMRVgV8GEQSrltOyOc	false	-	sufficient binding region:23-103|mutation:22-23	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0DP57	uniprotkb:P36544	intact:EBI-15486457|ensembl:ENSP00000319846|uniprotkb:D3DWI7|uniprotkb:G3XAC2|uniprotkb:Q86SR0|uniprotkb:Q9BZG9	intact:EBI-79333|uniprotkb:A8K7Q4|ensembl:ENSP00000303727|uniprotkb:Q15826|uniprotkb:Q96RH2|uniprotkb:Q99555|uniprotkb:Q9BXH0|uniprotkb:B4DFS0|uniprotkb:Q8IUZ4	psi-mi:slur2_human(display_long)|uniprotkb:SLURP2(gene name)|psi-mi:SLURP2(display_short)|uniprotkb:Secreted LY6/PLAUR domain-containing protein 2(gene name synonym)|uniprotkb:Secreted Ly-6/uPAR-related protein 2(gene name synonym)	psi-mi:acha7_human(display_long)|uniprotkb:CHRNA7(gene name)|psi-mi:CHRNA7(display_short)|uniprotkb:NACHRA7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lyukmanova et al. (2015)	pubmed:26905431|imex:IM-26256	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14973790|imex:IM-26256-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000283992(gene)|ensembl:ENST00000317543(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0030548"(acetylcholine receptor regulator activity)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0045202"(synapse)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0099601"(regulation of neurotransmitter receptor activity)|interpro:IPR016054(Ly-6 antigen / uPA receptor -like)|rcsb pdb:2N99|go:"GO:0005615"(extracellular space)|refseq:NP_803253.1	ensembl:ENSG00000175344(gene)|ensembl:ENST00000306901(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140059"(dendrite arborization)|refseq:NP_683709.1|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2MAW|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFM|rcsb pdb:5AFN|rcsb pdb:7EKI|rcsb pdb:7EKP|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|refseq:NP_000737.1|rcsb pdb:7EKT|go:"GO:1902004"(positive regulation of amyloid-beta formation)|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|reactome:R-HSA-629594|go:"GO:1905144"(response to acetylcholine)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1901214"(regulation of neuron death)|refseq:XP_016877373.1|refseq:NP_001177384.1|refseq:XP_005254807.1	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/11	2017/07/27	rogid:JVqjhtRXA1MoC66DHRY4fACpFdc9606	rogid:9wcnxJ2Eh9S6aVCvKwKSwLMJnMI9606	rigid:KKjdhJHXNPlqaRGI0KpjGEVVuQs	false	sufficient binding region:23-97|mutation:22-23	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P60615	uniprotkb:P36544	intact:EBI-7516391|uniprotkb:Q9PRI6|uniprotkb:Q9YI07|uniprotkb:P01378|uniprotkb:Q9YGD1|uniprotkb:Q9YI11|uniprotkb:Q9YI06|intact:MINT-5223718|uniprotkb:Q9YI09|uniprotkb:Q9YI10|uniprotkb:Q9YI13|uniprotkb:Q9YI12	intact:EBI-79333|uniprotkb:A8K7Q4|ensembl:ENSP00000303727|uniprotkb:Q15826|uniprotkb:Q96RH2|uniprotkb:Q99555|uniprotkb:Q9BXH0|uniprotkb:B4DFS0|uniprotkb:Q8IUZ4	psi-mi:3l21a_bunmu(display_long)|uniprotkb:Long neurotoxin 1(gene name synonym)|uniprotkb:Alpha-bungarotoxin, isoform A31(gene name synonym)|uniprotkb:Alpha-elapitoxin-Bm2a(gene name synonym)	psi-mi:acha7_human(display_long)|uniprotkb:CHRNA7(gene name)|psi-mi:CHRNA7(display_short)|uniprotkb:NACHRA7(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Lyukmanova et al. (2015)	pubmed:26905431|imex:IM-26256	taxid:8616(bunmu)|taxid:8616(Bungarus multicinctus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-14973793|imex:IM-26256-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P60615|interpro:IPR035076|interpro:IPR018354|interpro:IPR003571(Snake toxin)|go:"GO:0005576"(extracellular region)|go:"GO:0090729"(toxin activity)|rcsb pdb:1ABT|rcsb pdb:1BXP|rcsb pdb:1HAA|rcsb pdb:1HAJ|rcsb pdb:1HC9|rcsb pdb:1HOY|rcsb pdb:1IDG|rcsb pdb:1IDH|rcsb pdb:1IDI|rcsb pdb:1IDL|rcsb pdb:1IK8|rcsb pdb:1IKC|rcsb pdb:1JBD|rcsb pdb:1KC4|rcsb pdb:1KFH|rcsb pdb:1KL8|rcsb pdb:1L4W|rcsb pdb:1LJZ|rcsb pdb:1LK1|rcsb pdb:1RGJ|rcsb pdb:2ABX|rcsb pdb:2BTX|rcsb pdb:6UWZ	ensembl:ENSG00000175344(gene)|ensembl:ENST00000306901(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005216"(ion channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005892"(acetylcholine-gated channel complex)|go:"GO:0006811"(ion transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007271"(synaptic transmission, cholinergic)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007614"(short-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0022848"(acetylcholine-gated cation-selective channel activity)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0015464"(acetylcholine receptor activity)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035094"(response to nicotine)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050877"(nervous system process)|go:"GO:0050890"(cognition)|go:"GO:0050893"(sensory processing)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0098794"(postsynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0140059"(dendrite arborization)|refseq:NP_683709.1|go:"GO:1905920"(positive regulation of CoA-transferase activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR006029(Neurotransmitter-gated ion-channel transmembrane region)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR018000|interpro:IPR036719|interpro:IPR036734|rcsb pdb:2MAW|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFM|rcsb pdb:5AFN|rcsb pdb:7EKI|rcsb pdb:7EKP|interpro:IPR002394(Nicotinic acetylcholine receptor, N-terminal)|refseq:NP_000737.1|rcsb pdb:7EKT|go:"GO:1902004"(positive regulation of amyloid-beta formation)|rcsb pdb:7KOO|rcsb pdb:7KOQ|rcsb pdb:7KOX|reactome:R-HSA-629594|go:"GO:1905144"(response to acetylcholine)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1901214"(regulation of neuron death)|refseq:XP_016877373.1|refseq:NP_001177384.1|refseq:XP_005254807.1	-	comment:mint|function:"Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (alpha-7, alpha-8, and alpha-9) nicotinic acetylcholine receptors. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM)"	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/05/11	2017/05/23	rogid:H8HmrCO0Ummh3xuVj5FOUmoCcN08616	rogid:9wcnxJ2Eh9S6aVCvKwKSwLMJnMI9606	rigid:W28dvWeGoyjo6fcpulkC8C22lQ4	false	sufficient binding region:22-95	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)