#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31809	uniprotkb:P11224	intact:EBI-8663470|uniprotkb:Q61350|uniprotkb:Q61353|intact:MINT-4590618	intact:EBI-16196052|uniprotkb:O39227	psi-mi:ceam1_mouse(display_long)|uniprotkb:Ceacam1(gene name)|psi-mi:Ceacam1(display_short)|uniprotkb:Bgp(gene name synonym)|uniprotkb:Bgp1(gene name synonym)|uniprotkb:Biliary glycoprotein 1(gene name synonym)|uniprotkb:Murine hepatitis virus receptor(gene name synonym)|uniprotkb:MHVR1(gene name synonym)|uniprotkb:Biliary glycoprotein D(gene name synonym)	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:"MI:1247"(microscale thermophoresis)	Walls et al. (2016)	pubmed:26855426|doi:10.1038/nature16988|imex:IM-25366	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16196079|imex:IM-25366-1|dip:DIP-200979E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001915"(negative regulation of T cell mediated cytotoxicity)|go:"GO:0002859"(negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0003779"(actin binding)|go:"GO:0005130"(granulocyte colony-stimulating factor receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031005"(filamin binding)|go:"GO:0031528"(microvillus membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0014066"(regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015125"(bile acid transmembrane transporter activity)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0035726"(common myeloid progenitor cell proliferation)|go:"GO:0038016"(insulin receptor internalization)|go:"GO:0015721"(bile acid and bile salt transport)|go:"GO:0038158"(granulocyte colony-stimulating factor signaling pathway)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043318"(negative regulation of cytotoxic T cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0030054"(cell junction)|go:"GO:0030133"(transport vesicle)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1901143"(insulin catabolic process)|go:"GO:1903385"(regulation of homophilic cell adhesion)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000346"(negative regulation of hepatocyte proliferation)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:1L6Z|rcsb pdb:3R4D|rcsb pdb:5VST|rcsb pdb:6VSJ|interpro:IPR036179|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-6798695|refseq:NP_001034274.1|refseq:NP_001034275.1|dip:DIP-61461N	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	psi-mi:"MI:0465"(dip)	comment:mint|function:"Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein"	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:TVzltAt+4VNWHR+xzvc8oHRwQ1010090	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rigid:Y99xRD1y8eE2/yVdAd9yAjVKJ9Y	false	sufficient binding region:35-142	sufficient binding region:15-1231	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11224	uniprotkb:P11224	intact:EBI-16196052|uniprotkb:O39227	intact:EBI-16196052|uniprotkb:O39227	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:"MI:0067"(light scattering)	Walls et al. (2016)	pubmed:26855426|doi:10.1038/nature16988|imex:IM-25366	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16196118|imex:IM-25366-3|dip:DIP-200978E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/08	2017/08/10	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rigid:5rNkJ7rt9fT0v8b81I4UVRcB8cI	false	sufficient binding region:15-1231	sufficient binding region:15-1231	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11224	uniprotkb:P11224	intact:EBI-16196052|uniprotkb:O39227	intact:EBI-16196052|uniprotkb:O39227	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:"MI:0071"(molecular sieving)	Walls et al. (2016)	pubmed:26855426|doi:10.1038/nature16988|imex:IM-25366	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16196100|imex:IM-25366-2|dip:DIP-200978E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/08	2017/08/10	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rigid:5rNkJ7rt9fT0v8b81I4UVRcB8cI	false	sufficient binding region:15-1231	sufficient binding region:15-1231	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P11224	uniprotkb:P11224	intact:EBI-16196052|uniprotkb:O39227	intact:EBI-16196052|uniprotkb:O39227	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:spike_cvma5(display_long)|uniprotkb:S(gene name)|psi-mi:S(display_short)|uniprotkb:E2(gene name synonym)|uniprotkb:Peplomer protein(gene name synonym)|uniprotkb:3(orf name)	psi-mi:"MI:0410"(3D electron microscopy)	Walls et al. (2016)	pubmed:26855426|doi:10.1038/nature16988|imex:IM-25366	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	taxid:11142(cvma5)|taxid:11142("Murine coronavirus (strain A59)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16196137|imex:IM-25366-4|dip:DIP-200978E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0044173"(host cell endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0055036"(virion membrane)|go:"GO:0075509"(endocytosis involved in viral entry into host cell)|interpro:IPR002552(Coronavirus S2 glycoprotein)|interpro:IPR018548|interpro:IPR032500|interpro:IPR042578|interpro:IPR043002|interpro:IPR043473|interpro:IPR043607|interpro:IPR043614|interpro:IPR036326|interpro:IPR044339|interpro:IPR044873|interpro:IPR044874|rcsb pdb:1WDF|rcsb pdb:1WDG|rcsb pdb:3JCL|rcsb pdb:6B3O|rcsb pdb:6VSJ|refseq:NP_045300.1|dip:DIP-61967N	psi-mi:"MI:0465"(dip)	-	-	dataset:Coronavirus - Interactions investigated in the context of Coronavirus|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	-	2017/08/08	2017/08/10	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rogid:6rg8ivahgyrx/wjATOTsFDqOrDw11142	rigid:5rNkJ7rt9fT0v8b81I4UVRcB8cI	false	sufficient binding region:15-1231	sufficient binding region:15-1231	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)