#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99726	uniprotkb:Q6XR72	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918018|imex:IM-25690-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	-	-	figure legend:2A|antagonist:"DSP (cross-linking)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/02/22	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:KTI1umLJk5GDCa5k8PONznkPyYw	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6XR72	uniprotkb:Q6XR72	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918027|imex:IM-25690-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	-	-	figure legend:2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/02/22	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:B48JgGmwDQYOLKL/JvJdk0qUPqw	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BRI3	uniprotkb:Q99376	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918041|imex:IM-25690-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	comment:mint	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:K6FfixxnPblbaGQJCT2l010GUc8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BRI3	uniprotkb:Q99726	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918041|imex:IM-25690-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	comment:mint	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:K6FfixxnPblbaGQJCT2l010GUc8	false	green fluorescent protein tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14863	uniprotkb:Q99376	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918051|imex:IM-25690-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	-	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:PuTXTGQNtmpX13rVfYZXpZLNqwA	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14863	uniprotkb:Q99726	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918051|imex:IM-25690-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:PuTXTGQNtmpX13rVfYZXpZLNqwA	false	green fluorescent protein tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14863	uniprotkb:Q6XR72	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918086|imex:IM-25690-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	-	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:lhpL9y1C+GapLqh9rwWcgmcYfCE	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14863	uniprotkb:Q99376	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918086|imex:IM-25690-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	-	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:lhpL9y1C+GapLqh9rwWcgmcYfCE	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BRI3	uniprotkb:Q6XR72	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918096|imex:IM-25690-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	comment:mint	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:9WWYKSgfdS/YCQMJY1Xfzs7lg9Q	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BRI3	uniprotkb:Q99376	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918096|imex:IM-25690-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	comment:mint	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:9WWYKSgfdS/YCQMJY1Xfzs7lg9Q	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14863	uniprotkb:Q99726	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918171|imex:IM-25690-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:6  A/C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/02/22	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:wv0cIudCzJPhOn09pBB1+6XAoCg	false	green fluorescent protein tag:?-?	myc tag:c-c|mutation decreasing interaction strength:257-257|mutation decreasing interaction strength:262-262	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99726	uniprotkb:Q6XR72	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918206|imex:IM-25690-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	-	-	figure legend:6G|agonist:H2O2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/02/22	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:KTI1umLJk5GDCa5k8PONznkPyYw	false	myc tag:c-c	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BRI3	uniprotkb:Q99376	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945200|imex:IM-25690-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	comment:mint	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:h17ygJhkYsMLdfaTdvbmJPvmnlg	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14863	uniprotkb:Q99376	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945210|imex:IM-25690-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	-	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:U9aAYt3TIeChbKWC64kYmQaI1G8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14863	uniprotkb:Q99726	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13949493|imex:IM-25690-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:6 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/03/15	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:wv0cIudCzJPhOn09pBB1+6XAoCg	false	myc tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P02786	uniprotkb:Q6XR72	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918150|imex:IM-25690-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	go:"GO:0055037"(recycling endosome)	-	-	figure legend:5A, 8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/03/07	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:bXmwrG0iONmJP3541Pc7W1ebmRg	false	-	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02786	uniprotkb:O14863	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918150|imex:IM-25690-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	go:"GO:0055037"(recycling endosome)	-	-	figure legend:5A, 8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/03/07	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rigid:bXmwrG0iONmJP3541Pc7W1ebmRg	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:O14863	uniprotkb:Q99726	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918140|imex:IM-25690-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/02/22	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:wv0cIudCzJPhOn09pBB1+6XAoCg	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9BRI3	uniprotkb:Q99726	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918121|imex:IM-25690-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	comment:mint	-	figure legend:5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/02/22	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:hGHnLLhP0/2vc1VRqI16+oYofGA	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9BRI3	uniprotkb:Q6XR72	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918160|imex:IM-25690-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	comment:mint	-	figure legend:5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/02/22	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:Hh9sALyhCXg1XGBxEkEjkjsSMiQ	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02786	uniprotkb:Q6XR72	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918219|imex:IM-25690-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	go:"GO:0055037"(recycling endosome)	-	-	figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/03/07	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:tWqRxNYdD6pf0tNxDhosbaVa6mI	false	-	myc tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P02786	uniprotkb:Q99726	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918219|imex:IM-25690-14	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	go:"GO:0055037"(recycling endosome)	-	-	figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/03/07	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:tWqRxNYdD6pf0tNxDhosbaVa6mI	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6XR72	uniprotkb:P02786	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	intact:EBI-355727|uniprotkb:Q59G55|uniprotkb:Q9UCN0|uniprotkb:Q9UCU5|uniprotkb:Q9UDF9|uniprotkb:Q9UK21|uniprotkb:Q1HE24|uniprotkb:D3DXB0|ensembl:ENSP00000353224|ensembl:ENSP00000376197	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:tfr1_human(display_long)|uniprotkb:TFRC(gene name)|psi-mi:TFRC(display_short)|uniprotkb:T9(gene name synonym)|uniprotkb:p90(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945482|imex:IM-25690-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	refseq:NP_001121620.1|refseq:NP_003225.2|refseq:NP_001300894.1|refseq:NP_001300895.1|ensembl:ENSG00000072274(gene)|ensembl:ENST00000360110(transcript)|ensembl:ENST00000392396(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:P02786|rcsb pdb:1CX8|rcsb pdb:1DE4|rcsb pdb:1SUV|rcsb pdb:2NSU|rcsb pdb:3KAS|rcsb pdb:3S9L|rcsb pdb:3S9M|rcsb pdb:3S9N|rcsb pdb:6D03|rcsb pdb:6D04|rcsb pdb:6D05|rcsb pdb:6GSR|rcsb pdb:6H5I|rcsb pdb:6OKD|rcsb pdb:6W3H|rcsb pdb:6WRV|rcsb pdb:6WRW|rcsb pdb:6WRX|rcsb pdb:6Y76|reactome:R-HSA-432722|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-917977|reactome:R-HSA-9696270|reactome:R-HSA-9696273|dip:DIP-2736N	go:"GO:0055037"(recycling endosome)	-	-	figure legend:8B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2017/02/22	2017/03/07	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rogid:TWJEaKElrOrDMMqSefG5icrTbIU9606	rigid:guWhtQlSDqrhqmmfyR4qlWtRQsU	false	myc tag:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q99726	uniprotkb:Q6XR72	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13918194|imex:IM-25690-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	-	-	figure legend:6D and F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/02/22	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:KTI1umLJk5GDCa5k8PONznkPyYw	false	myc tag:c-c|mutation decreasing interaction strength:257-257|mutation decreasing interaction strength:262-262	green fluorescent protein tag:?-?|mutation decreasing interaction strength:4-4	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14863	uniprotkb:Q99726	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945081|imex:IM-25690-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:6  A,  and C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/03/07	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:wv0cIudCzJPhOn09pBB1+6XAoCg	false	green fluorescent protein tag:?-?	myc tag:c-c|mutation decreasing interaction strength:257-257|mutation decreasing interaction strength:262-262	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99376	uniprotkb:Q99726	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945051|imex:IM-25690-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:PuTXTGQNtmpX13rVfYZXpZLNqwA	false	-	myc tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99376	uniprotkb:O14863	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945051|imex:IM-25690-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rigid:PuTXTGQNtmpX13rVfYZXpZLNqwA	false	-	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BRI3	uniprotkb:Q6XR72	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945071|imex:IM-25690-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	-	comment:mint	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/03/07	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rigid:Hh9sALyhCXg1XGBxEkEjkjsSMiQ	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6XR72	uniprotkb:O14863	intact:EBI-13917996|ensembl:ENSP00000355893|uniprotkb:Q49AL9|uniprotkb:Q9NPW0	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	psi-mi:znt10_human(display_long)|uniprotkb:Manganese transporter SLC30A10(gene name synonym)|uniprotkb:SLC30A10(gene name)|psi-mi:SLC30A10(display_short)|uniprotkb:ZNT10(gene name synonym)|uniprotkb:ZNT8(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945061|imex:IM-25690-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196660(gene)|ensembl:ENST00000366926(transcript)|go:"GO:0005384"(manganese ion transmembrane transporter activity)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-HSA-425410|refseq:NP_061183.2	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/03/07	rogid:Dn3Fzx+xOD2SJv/ZfUrLEwacm209606	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rigid:I8Fh1EUVdI4RUMLLLsC2rUvurAw	false	myc tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9BRI3	uniprotkb:Q99726	intact:EBI-8644112|ensembl:ENSP00000363396|intact:MINT-8163383|uniprotkb:Q71RC8	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt2_human(display_long)|uniprotkb:SLC30A2(gene name)|psi-mi:SLC30A2(display_short)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)|uniprotkb:ZNT2(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945032|imex:IM-25690-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000158014(gene)|ensembl:ENST00000374278(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001004434.1|refseq:NP_115902.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	comment:mint	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/03/07	rogid:E8UyE30F1s0H0A4awhgqZ6MIEuU9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:hGHnLLhP0/2vc1VRqI16+oYofGA	false	green fluorescent protein tag:?-?	myc tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14863	uniprotkb:Q99376	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-2112551|intact:EBI-21232392|uniprotkb:G3V679|ensembl:ENSRNOP00000002407	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:tfr1_rat(display_long)|uniprotkb:Tfrc(gene name)|psi-mi:Tfrc(display_short)|uniprotkb:Trfr(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945224|imex:IM-25690-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	rgd:70488|refseq:NP_073203.1|refseq:XP_006248524.1|refseq:XP_006248525.1|ensembl:ENSRNOG00000001766(gene)|ensembl:ENSRNOT00000002407(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004998"(transferrin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006826"(iron ion transport)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0006953"(acute-phase response)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010033"(response to organic substance)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033572"(transferrin transport)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0046688"(response to copper ion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051087"(chaperone binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR003137(Protease-associated PA)|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR029513|interpro:IPR036757|interpro:IPR037324|interpro:IPR039373|mint:Q99376|reactome:R-RNO-432722|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8980692|reactome:R-RNO-9013026|reactome:R-RNO-9013106|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013408|reactome:R-RNO-9013423|reactome:R-RNO-917977|reactome:R-RNO-9696270|reactome:R-RNO-9696273|go:"GO:0016323"(basolateral plasma membrane)	-	-	-	figure legend:4A|comment:Cross-linking with DSP decreases association with endogenous Tfrc|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2020/08/14	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:vqeLiefAr+SqCtwOnGUhDJPpcHo10116	rigid:U9aAYt3TIeChbKWC64kYmQaI1G8	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14863	uniprotkb:Q99726	intact:EBI-13918058|ensembl:ENSP00000261867|uniprotkb:Q8TC39	intact:EBI-10294651|uniprotkb:Q8TC03|ensembl:ENSP00000233535	psi-mi:znt4_human(display_long)|uniprotkb:SLC30A4(gene name)|psi-mi:SLC30A4(display_short)|uniprotkb:ZNT4(gene name synonym)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)	psi-mi:znt3_human(display_long)|uniprotkb:SLC30A3(gene name)|psi-mi:SLC30A3(display_short)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:ZNT3(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13949438|imex:IM-25690-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000104154(gene)|ensembl:ENST00000261867(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|refseq:NP_037441.2|refseq:XP_011520299.1|refseq:XP_016878049.1	refseq:NP_003450.2|ensembl:ENSG00000115194(gene)|ensembl:ENST00000233535(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016020"(membrane)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|reactome:R-HSA-435368|refseq:NP_001305878.1|refseq:NP_001305879.1|refseq:NP_001305880.1	-	-	-	figure legend:6 B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells)	-	2017/02/22	2017/03/15	rogid:luNf2sMaQX5nac5ewEeitand9Mw9606	rogid:ioKDHkjnv+VhEwx9afk+JC++0nk9606	rigid:wv0cIudCzJPhOn09pBB1+6XAoCg	false	myc tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P97441	uniprotkb:Q2HJ10	intact:EBI-775973|uniprotkb:P97511|ensembl:ENSMUSP00000031037	intact:EBI-13945312|ensembl:ENSMUSP00000101500	psi-mi:znt3_mouse(display_long)|uniprotkb:Solute carrier family 30 member 3(gene name synonym)|uniprotkb:Slc30a3(gene name)|psi-mi:Slc30a3(display_short)|uniprotkb:Znt3(gene name synonym)	psi-mi:znt2_mouse(display_long)|uniprotkb:Slc30a2(gene name)|psi-mi:Slc30a2(display_short)|uniprotkb:Znt2(gene name synonym)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945332|imex:IM-25690-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035903.2|ensembl:ENSMUSG00000029151(gene)|ensembl:ENSMUST00000031037(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006829"(zinc ion transport)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0043005"(neuron projection)|go:"GO:0051050"(positive regulation of transport)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|go:"GO:0097457"(hippocampal mossy fiber)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099180"(zinc ion import into synaptic vesicle)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837|mint:P97441	ensembl:ENSMUSG00000028836(gene)|ensembl:ENSMUST00000105874(transcript)|refseq:NP_001034766.1|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006829"(zinc ion transport)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837	-	-	-	figure legend:4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2017/02/22	2017/03/07	rogid:CDJ5qHxjX2G5jUKa87/jNEQiOlo10090	rogid:QDKYsJ0FNgBE0Xzxyopt0A4Mcxs10090	rigid:+xq+Pd2qPO8P/KyEgHR1aGaKeME	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2HJ10	uniprotkb:Q3UVU3	intact:EBI-13945312|ensembl:ENSMUSP00000101500	intact:EBI-13945374|ensembl:ENSMUSP00000053181|uniprotkb:Q32NY2	psi-mi:znt2_mouse(display_long)|uniprotkb:Slc30a2(gene name)|psi-mi:Slc30a2(display_short)|uniprotkb:Znt2(gene name synonym)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)	psi-mi:znt10_mouse(display_long)|uniprotkb:Slc30a10(gene name)|psi-mi:Slc30a10(display_short)|uniprotkb:Znt10(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945337|imex:IM-25690-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028836(gene)|ensembl:ENSMUST00000105874(transcript)|refseq:NP_001034766.1|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006829"(zinc ion transport)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837	go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-MMU-425410|ensembl:ENSMUSG00000026614(gene)|ensembl:ENSMUST00000061093(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|refseq:NP_001028458.1	-	-	-	figure legend:4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2017/02/22	2017/03/07	rogid:QDKYsJ0FNgBE0Xzxyopt0A4Mcxs10090	rogid:ZUcFF9ilFaBOoVofHJZyzogNbDo10090	rigid:YOJQWgBmbjB6RO/JBhv8TPjmtYA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q2HJ10	uniprotkb:Q3UVU3	intact:EBI-13945312|ensembl:ENSMUSP00000101500	intact:EBI-13945374|ensembl:ENSMUSP00000053181|uniprotkb:Q32NY2	psi-mi:znt2_mouse(display_long)|uniprotkb:Slc30a2(gene name)|psi-mi:Slc30a2(display_short)|uniprotkb:Znt2(gene name synonym)|uniprotkb:Solute carrier family 30 member 2(gene name synonym)	psi-mi:znt10_mouse(display_long)|uniprotkb:Slc30a10(gene name)|psi-mi:Slc30a10(display_short)|uniprotkb:Znt10(gene name synonym)|uniprotkb:Solute carrier family 30 member 10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhao et al. (2016)	pubmed:26728129|imex:IM-25690	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-13945403|imex:IM-25690-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028836(gene)|ensembl:ENSMUST00000105874(transcript)|refseq:NP_001034766.1|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006829"(zinc ion transport)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0061090"(positive regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|interpro:IPR036837	go:"GO:0071579"(regulation of zinc ion transport)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1905802"(regulation of cellular response to manganese ion)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|reactome:R-MMU-425410|ensembl:ENSMUSG00000026614(gene)|ensembl:ENSMUST00000061093(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006828"(manganese ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010312"(detoxification of zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0055037"(recycling endosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0071577"(zinc ion transmembrane transport)|refseq:NP_001028458.1	-	-	-	figure legend:4F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-kidney)|taxid:10090(Mus musculus)	-	2017/02/22	2017/03/07	rogid:QDKYsJ0FNgBE0Xzxyopt0A4Mcxs10090	rogid:ZUcFF9ilFaBOoVofHJZyzogNbDo10090	rigid:YOJQWgBmbjB6RO/JBhv8TPjmtYA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)