#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02454	uniprotkb:Q9UBG0	intact:EBI-915744|uniprotkb:P02455|uniprotkb:Q63079|ensembl:ENSRNOP00000005311|uniprotkb:A3KNA1	intact:EBI-1104992|ensembl:ENSP00000307513|uniprotkb:Q7LGE7|uniprotkb:Q9Y5P9|uniprotkb:D3DU08|uniprotkb:A6H8K4	psi-mi:co1a1_rat(display_long)|uniprotkb:Alpha-1 type I collagen(gene name synonym)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)	psi-mi:mrc2_human(display_long)|uniprotkb:MRC2(gene name)|psi-mi:MRC2(display_short)|uniprotkb:ENDO180(gene name synonym)|uniprotkb:KIAA0709(gene name synonym)|uniprotkb:UPARAP(gene name synonym)|uniprotkb:Macrophage mannose receptor 2(gene name synonym)|uniprotkb:Endocytic receptor 180(gene name synonym)|uniprotkb:Urokinase-type plasminogen activator receptor-associated protein(gene name synonym)|uniprotkb:CLEC13E(gene name synonym)|uniprotkb:C-type lectin domain family 13 member E(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Paracuellos et al. (2015)	pubmed:26481812|doi:10.1016/j.str.2015.09.004|imex:IM-25128	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16182061|imex:IM-25128-1|dip:DIP-200466E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:61817|refseq:NP_445756.1|ensembl:ENSRNOG00000003897(gene)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|ensembl:ENSRNOT00000005311(transcript)|go:"GO:0030141"(secretory granule)|go:"GO:0001501"(skeletal system development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007584"(response to nutrient)|go:"GO:0007601"(visual perception)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|rcsb pdb:3HQV|rcsb pdb:3HR2|reactome:R-RNO-114604|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2243919|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-430116|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902617"(response to fluoride)|dip:DIP-36887N|reactome:R-RNO-75892|reactome:R-RNO-76009|reactome:R-RNO-8874081|reactome:R-RNO-8948216	ensembl:ENSG00000011028(gene)|ensembl:ENST00000303375(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005518"(collagen binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001304(C-type lectin)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|interpro:IPR035992|interpro:IPR036943|rcsb pdb:5AO5|rcsb pdb:5AO6|rcsb pdb:5E4K|rcsb pdb:5E4L|rcsb pdb:5EW6|reactome:R-HSA-1236978|refseq:NP_006030.2|dip:DIP-37631N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:eng4MkFnf/zWoFkxosROYXl6VuU10116	rogid:/Avt/3LBOV9xvNzhxpCGV+Bt8/M9606	rigid:WIpdY/oIVGXUAHfJm1WGLABNNas	false	-	sufficient binding region:172-513|mutation disrupting interaction strength:181-181,179-179|mutation disrupting interaction strength:193-193|mutation disrupting interaction strength:208-208,206-206|mutation disrupting interaction strength:219-219|mutation decreasing interaction strength:294-294,292-292	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02454	uniprotkb:Q9UBG0	intact:EBI-915744|uniprotkb:P02455|uniprotkb:Q63079|ensembl:ENSRNOP00000005311|uniprotkb:A3KNA1	intact:EBI-1104992|ensembl:ENSP00000307513|uniprotkb:Q7LGE7|uniprotkb:Q9Y5P9|uniprotkb:D3DU08|uniprotkb:A6H8K4	psi-mi:co1a1_rat(display_long)|uniprotkb:Alpha-1 type I collagen(gene name synonym)|uniprotkb:Col1a1(gene name)|psi-mi:Col1a1(display_short)	psi-mi:mrc2_human(display_long)|uniprotkb:MRC2(gene name)|psi-mi:MRC2(display_short)|uniprotkb:ENDO180(gene name synonym)|uniprotkb:KIAA0709(gene name synonym)|uniprotkb:UPARAP(gene name synonym)|uniprotkb:Macrophage mannose receptor 2(gene name synonym)|uniprotkb:Endocytic receptor 180(gene name synonym)|uniprotkb:Urokinase-type plasminogen activator receptor-associated protein(gene name synonym)|uniprotkb:CLEC13E(gene name synonym)|uniprotkb:C-type lectin domain family 13 member E(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Paracuellos et al. (2015)	pubmed:26481812|doi:10.1016/j.str.2015.09.004|imex:IM-25128	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16182098|imex:IM-25128-2|dip:DIP-200466E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:61817|refseq:NP_445756.1|ensembl:ENSRNOG00000003897(gene)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0015031"(protein transport)|ensembl:ENSRNOT00000005311(transcript)|go:"GO:0030141"(secretory granule)|go:"GO:0001501"(skeletal system development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0001503"(ossification)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001958"(endochondral ossification)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0002020"(protease binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005584"(collagen type I trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007584"(response to nutrient)|go:"GO:0007601"(visual perception)|go:"GO:1902618"(cellular response to fluoride)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|rcsb pdb:3HQV|rcsb pdb:3HR2|reactome:R-RNO-114604|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-202733|reactome:R-RNO-216083|reactome:R-RNO-2243919|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-430116|go:"GO:0032355"(response to estradiol)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034505"(tooth mineralization)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043588"(skin development)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044691"(tooth eruption)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0051591"(response to cAMP)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071306"(cellular response to vitamin E)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902617"(response to fluoride)|dip:DIP-36887N|reactome:R-RNO-75892|reactome:R-RNO-76009|reactome:R-RNO-8874081|reactome:R-RNO-8948216	ensembl:ENSG00000011028(gene)|ensembl:ENST00000303375(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005518"(collagen binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001304(C-type lectin)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|interpro:IPR035992|interpro:IPR036943|rcsb pdb:5AO5|rcsb pdb:5AO6|rcsb pdb:5E4K|rcsb pdb:5E4L|rcsb pdb:5EW6|reactome:R-HSA-1236978|refseq:NP_006030.2|dip:DIP-37631N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/08	2017/08/10	rogid:eng4MkFnf/zWoFkxosROYXl6VuU10116	rogid:/Avt/3LBOV9xvNzhxpCGV+Bt8/M9606	rigid:WIpdY/oIVGXUAHfJm1WGLABNNas	false	-	sufficient binding region:172-513|mutation disrupting interaction strength:181-181,179-179|mutation disrupting interaction strength:193-193|mutation disrupting interaction strength:208-208,206-206|mutation disrupting interaction strength:219-219|mutation decreasing interaction strength:294-294,292-292	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)