#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31421	uniprotkb:P31421	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	intact:EBI-7090147|ensembl:ENSRNOP00000017607|intact:MINT-146442	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:grm2_rat(display_long)|uniprotkb:Grm2(gene name)|psi-mi:Grm2(display_short)|uniprotkb:Gprc1b(gene name synonym)|uniprotkb:Mglur2(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Vafabakhsh et al. (2015)	pubmed:26258295|doi:10.1038/nature14679|imex:IM-24585	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167842|imex:IM-24585-1|dip:DIP-199264E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N	ensembl:ENSRNOG00000013171(gene)|ensembl:ENSRNOT00000017607(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0010467"(gene expression)|go:"GO:0014047"(glutamate secretion)|go:"GO:0014048"(regulation of glutamate secretion)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035095"(behavioral response to nicotine)|go:"GO:0042220"(response to cocaine)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0090461"(glutamate homeostasis)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:2001023"(regulation of response to drug)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001458(GPCR, family 3, metabotropic glutamate receptor 2)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31421|reactome:R-RNO-418594|reactome:R-RNO-420499|refseq:XP_017450945.1|refseq:XP_017450946.1|refseq:NP_001099181.1|rgd:2743|dip:DIP-41937N	psi-mi:"MI:0465"(dip)	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	rogid:LVjjD/Uvv4io40UWVuFTCMetoxw10116	rigid:0UkRwpHgvtlI3yYYAnG1C125Jp4	false	alexa label:n-n	cy3 label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P31422	uniprotkb:P31422	intact:EBI-7974832|intact:MINT-1773162|ensembl:ENSRNOP00000007572	intact:EBI-7974832|intact:MINT-1773162|ensembl:ENSRNOP00000007572	psi-mi:grm3_rat(display_long)|uniprotkb:Grm3(gene name)|psi-mi:Grm3(display_short)|uniprotkb:Gprc1c(gene name synonym)|uniprotkb:Mglur3(gene name synonym)	psi-mi:grm3_rat(display_long)|uniprotkb:Grm3(gene name)|psi-mi:Grm3(display_short)|uniprotkb:Gprc1c(gene name synonym)|uniprotkb:Mglur3(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Vafabakhsh et al. (2015)	pubmed:26258295|doi:10.1038/nature14679|imex:IM-24585	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-16167863|imex:IM-24585-2|dip:DIP-199265E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001099182.1|rgd:2744|dip:DIP-41143N|ensembl:ENSRNOG00000005519(gene)|ensembl:ENSRNOT00000007572(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001234(GPCR, family 3, metabotropic glutamate receptor 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31422|rcsb pdb:2E4U|rcsb pdb:2E4V|rcsb pdb:2E4W|rcsb pdb:2E4X|rcsb pdb:2E4Y|reactome:R-RNO-418594|reactome:R-RNO-420499	refseq:NP_001099182.1|rgd:2744|dip:DIP-41143N|ensembl:ENSRNOG00000005519(gene)|ensembl:ENSRNOT00000007572(transcript)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001641"(group II metabotropic glutamate receptor activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0010467"(gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001234(GPCR, family 3, metabotropic glutamate receptor 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR028082|interpro:IPR038550|mint:P31422|rcsb pdb:2E4U|rcsb pdb:2E4V|rcsb pdb:2E4W|rcsb pdb:2E4X|rcsb pdb:2E4Y|reactome:R-RNO-418594|reactome:R-RNO-420499	psi-mi:"MI:0465"(dip)	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	function:Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity|comment:mint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:seBDkbV7Eb+eVctXAZ9F1KWrgJI10116	rogid:seBDkbV7Eb+eVctXAZ9F1KWrgJI10116	rigid:MZFFHP5Z+xYGfKrIZhcwg2GUABQ	false	alexa label:n-n	cy3 label:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)