#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32121	uniprotkb:P28223-1	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	intact:EBI-15573967|ensembl:ENSP00000437737	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Viñals et al. (2015)	pubmed:26158621|doi:10.1371/journal.pbio.1002194|imex:IM-24566	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-16163885|imex:IM-24566-1|dip:DIP-199213E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rigid:367Svfu9pR775ek7XzWRJWNGjTI	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28223-1	uniprotkb:P21554	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0012"(bioluminescence resonance energy transfer)	Viñals et al. (2015)	pubmed:26158621|doi:10.1371/journal.pbio.1002194|imex:IM-24566	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-16163906|imex:IM-24566-2|dip:DIP-199212E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:9CKOxSHIMkG7hEUmmSkirCr3pnU	false	renilla luciferase protein tag:c-c	yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P28223-1	uniprotkb:P21554	intact:EBI-15573967|ensembl:ENSP00000437737	intact:EBI-2909859|ensembl:ENSP00000358511|ensembl:ENSP00000358513|ensembl:ENSP00000412192|ensembl:ENSP00000446702|ensembl:ENSP00000446819|uniprotkb:B2R9T4|uniprotkb:Q13949|uniprotkb:Q495Z0|uniprotkb:Q4PLI4|uniprotkb:Q4VBM6|uniprotkb:Q5JVL5|uniprotkb:Q5UB37|uniprotkb:Q9UNN0|uniprotkb:E1P512	psi-mi:p28223-1(display_long)|uniprotkb:HTR2A(gene name)|psi-mi:HTR2A(display_short)|uniprotkb:HTR2(gene name synonym)|uniprotkb:Serotonin receptor 2A(gene name synonym)	psi-mi:cnr1_human(display_long)|uniprotkb:CNR1(gene name)|psi-mi:CNR1(display_short)|uniprotkb:CNR(gene name synonym)|uniprotkb:CANN6(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Viñals et al. (2015)	pubmed:26158621|doi:10.1371/journal.pbio.1002194|imex:IM-24566	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16163927|imex:IM-24566-3|dip:DIP-199212E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102468(gene)|ensembl:ENST00000542664(transcript)|intact:EBI-6656333(isoform-parent)	go:"GO:0099635"(voltage-gated calcium channel activity involved in positive regulation of presynaptic cytosolic calcium levels)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000810(Cannabinoid receptor, type 1)|interpro:IPR002230(Cannabinoid receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:1LVQ|rcsb pdb:1LVR|rcsb pdb:2B0Y|rcsb pdb:2KOE|rcsb pdb:2MZ2|rcsb pdb:2MZ3|rcsb pdb:2MZA|rcsb pdb:5TGZ|rcsb pdb:5U09|rcsb pdb:5XR8|rcsb pdb:5XRA|rcsb pdb:6KPG|rcsb pdb:6KQI|rcsb pdb:6N4B|reactome:R-HSA-373076|reactome:R-HSA-418594|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0007584"(response to nutrient)|go:"GO:0007613"(memory)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014063"(negative regulation of serotonin secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019222"(regulation of metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030426"(growth cone)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|ensembl:ENSG00000118432(gene)|ensembl:ENST00000369499(transcript)|ensembl:ENST00000369501(transcript)|ensembl:ENST00000428600(transcript)|ensembl:ENST00000549890(transcript)|ensembl:ENST00000551417(transcript)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004949"(cannabinoid receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0033004"(negative regulation of mast cell activation)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0035094"(response to nicotine)|go:"GO:0038171"(cannabinoid signaling pathway)|go:"GO:0042220"(response to cocaine)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045759"(negative regulation of action potential)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060405"(regulation of penile erection)|go:"GO:0098921"(retrograde trans-synaptic signaling by endocannabinoid)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|refseq:XP_011533726.1|refseq:XP_011533727.1|refseq:XP_011533728.1|refseq:XP_011533730.1|refseq:NP_001153698.1|refseq:NP_001153730.1|refseq:NP_001153731.1|refseq:NP_057167.2|refseq:NP_149421.2|refseq:XP_016865727.1|refseq:XP_016865728.1|refseq:XP_016865729.1|refseq:XP_006715393.1|dip:DIP-61575N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:wwxBh+3zPyTL6rfTCnViWTHndzo9606	rogid:lqrlYa5VAmUZyZnutQlhneY1jLc9606	rigid:9CKOxSHIMkG7hEUmmSkirCr3pnU	false	nYFP:c-c	cYFP:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)