#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:B6YWB8	uniprotkb:B6YWB8	intact:EBI-16149952|ensemblbacteria:ACJ16381	intact:EBI-16149952|ensemblbacteria:ACJ16381	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:"MI:0071"(molecular sieving)	Jung et al. (2015)	pubmed:25773141|doi:10.1016/j.str.2015.01.021|imex:IM-24222	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16149963|imex:IM-24222-1|dip:DIP-198755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rigid:eClBKiBe2PZ5j2EC/6nv/G/08sw	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B6YWC1	uniprotkb:B6YWB8	intact:EBI-16149979|ensemblbacteria:ACJ16384	intact:EBI-16149952|ensemblbacteria:ACJ16381	psi-mi:csm4_theon(display_long)|uniprotkb:csm4(gene name)|psi-mi:csm4(display_short)|uniprotkb:CRISPR type III A-associated RAMP protein Csm4(gene name synonym)|uniprotkb:TON_0896(locus name)	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:"MI:0067"(light scattering)	Jung et al. (2015)	pubmed:25773141|doi:10.1016/j.str.2015.01.021|imex:IM-24222	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16149987|imex:IM-24222-2|dip:DIP-198756E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ACJ16384(transcript)|ensemblbacteria:TON_0896(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR005510(Protein of unknown function DUF314)|rcsb pdb:6IQW|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571856.1|dip:DIP-61405N	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:Q/ZvVuo9BNjge2C18/88zzWqjZo523850	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rigid:GA0ZvKfbhJjNzwrlySRPraUJM/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B6YWB8	uniprotkb:B6YWB8	intact:EBI-16149952|ensemblbacteria:ACJ16381	intact:EBI-16149952|ensemblbacteria:ACJ16381	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:"MI:0067"(light scattering)	Jung et al. (2015)	pubmed:25773141|doi:10.1016/j.str.2015.01.021|imex:IM-24222	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16150004|imex:IM-24222-3|dip:DIP-198755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rigid:eClBKiBe2PZ5j2EC/6nv/G/08sw	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B6YWB8	uniprotkb:B6YWB8	intact:EBI-16149952|ensemblbacteria:ACJ16381	intact:EBI-16149952|ensemblbacteria:ACJ16381	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Jung et al. (2015)	pubmed:25773141|doi:10.1016/j.str.2015.01.021|imex:IM-24222	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16150021|imex:IM-24222-4|dip:DIP-198755E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rigid:eClBKiBe2PZ5j2EC/6nv/G/08sw	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:B6YWC1	uniprotkb:B6YWB8	intact:EBI-16149979|ensemblbacteria:ACJ16384	intact:EBI-16149952|ensemblbacteria:ACJ16381	psi-mi:csm4_theon(display_long)|uniprotkb:csm4(gene name)|psi-mi:csm4(display_short)|uniprotkb:CRISPR type III A-associated RAMP protein Csm4(gene name synonym)|uniprotkb:TON_0896(locus name)	psi-mi:cas10_theon(display_long)|uniprotkb:csm1(gene name)|psi-mi:csm1(display_short)|uniprotkb:Cyclic oligoadenylate synthase(gene name synonym)|uniprotkb:ToCsm1(gene name synonym)|uniprotkb:cas10(gene name synonym)|uniprotkb:TON_0893(locus name)	psi-mi:"MI:0071"(molecular sieving)	Jung et al. (2015)	pubmed:25773141|doi:10.1016/j.str.2015.01.021|imex:IM-24222	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	taxid:523850(theon)|taxid:523850("Thermococcus onnurineus (strain NA1)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16150037|imex:IM-24222-5|dip:DIP-198756E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblbacteria:ACJ16384(transcript)|ensemblbacteria:TON_0896(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR005510(Protein of unknown function DUF314)|rcsb pdb:6IQW|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571856.1|dip:DIP-61405N	ensemblbacteria:ACJ16381(transcript)|ensemblbacteria:TON_0893(gene)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0016740"(transferase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000160(GGDEF)|interpro:IPR006674(Metal-dependent phosphohydrolase, HD region, subdomain)|interpro:IPR013408(CRISPR-associated protein Csm1)|interpro:IPR041062|interpro:IPR043128|rcsb pdb:4UW2|rcsb pdb:6IQW|rcsb pdb:6KBD|rcsb pdb:6KC0|rcsb pdb:6MUA|rcsb pdb:6MUR|rcsb pdb:6MUS|rcsb pdb:6MUT|rcsb pdb:6MUU|rcsb pdb:6O73|rcsb pdb:6O74|rcsb pdb:6O75|rcsb pdb:6O78|rcsb pdb:6O79|rcsb pdb:6O7B|rcsb pdb:6O7D|rcsb pdb:6O7E|rcsb pdb:6O7H|rcsb pdb:6O7I|refseq:WP_012571853.1|dip:DIP-61404N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/08	2017/08/10	rogid:Q/ZvVuo9BNjge2C18/88zzWqjZo523850	rogid:Q6ApDoIb76GZLF4gV01giuwnqF4523850	rigid:GA0ZvKfbhJjNzwrlySRPraUJM/8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)