#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-4399559	uniprotkb:Q9UMW8	dip:DIP-24261N	intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2015)	pubmed:25307056|doi:"https://doi.org/10.1038/nature13801"|imex:IM-24321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16123539|imex:IM-24321-1|dip:DIP-198912E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606	rigid:HpQI6VdRlrwQhdTN2rjHIJY9O8Q	false	ha tag:0-0	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13309-1	uniprotkb:Q9UMW8	intact:EBI-15490084|ensembl:ENSP00000274255	intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90	psi-mi:q13309-1(display_long)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:SKP2-alpha(isoform synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym)	psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2015)	pubmed:25307056|doi:"https://doi.org/10.1038/nature13801"|imex:IM-24321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16123558|imex:IM-24321-2|dip:DIP-198913E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-456291(isoform-parent)|ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)	refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606	rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606	rigid:Vzxum8a0reubz9sfZh/mevO0p/I	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05161	uniprotkb:Q9UMW8	intact:EBI-746466|uniprotkb:Q7Z2G2|uniprotkb:Q96GF0|intact:EBI-1056284|uniprotkb:Q5SVA4|ensembl:ENSP00000496832	intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90	psi-mi:isg15_human(display_long)|uniprotkb:ISG15(gene name)|psi-mi:ISG15(display_short)|uniprotkb:G1P2(gene name synonym)|uniprotkb:UCRP(gene name synonym)|uniprotkb:Interferon-induced 15 kDa protein(gene name synonym)|uniprotkb:Interferon-induced 17 kDa protein(gene name synonym)|uniprotkb:Ubiquitin cross-reactive protein(gene name synonym)	psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2015)	pubmed:25307056|doi:"https://doi.org/10.1038/nature13801"|imex:IM-24321	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16123577|imex:IM-24321-3|dip:DIP-198914E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005092.1|ensembl:ENSG00000187608(gene)|ensembl:ENST00000649529(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031386"(protein tag)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0032461"(positive regulation of protein oligomerization)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0034340"(response to type I interferon)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0070585"(protein localization to mitochondrion)|interpro:IPR000626(Ubiquitin)|interpro:IPR019956|interpro:IPR029071|mint:P05161|rcsb pdb:1Z2M|rcsb pdb:2HJ8|rcsb pdb:3PHX|rcsb pdb:3PSE|rcsb pdb:3R66|rcsb pdb:3RT3|rcsb pdb:3SDL|rcsb pdb:5TL6|rcsb pdb:5W8T|rcsb pdb:5W8U|rcsb pdb:6BI8|rcsb pdb:6FFA|rcsb pdb:6XA9|reactome:R-HSA-1169408|reactome:R-HSA-168276|reactome:R-HSA-168928|reactome:R-HSA-5656169|reactome:R-HSA-909733|reactome:R-HSA-936440|dip:DIP-29814N	refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/08	2017/08/10	rogid:k01VuKv72XNTX3hhlIT4Lr0Xl849606	rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606	rigid:I/MvIMjX24Cv6XPzwBgHPilGWRI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)