#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A5HZZ4 uniprotkb:P09803 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-984420|uniprotkb:Q61377 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16109916|imex:IM-24684-1|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:378-626|glutathione s tranferase tag:n-n sufficient binding region:157-369 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ5 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16109916|imex:IM-24684-1|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:378-626|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ6 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16109916|imex:IM-24684-1|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:378-626|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ5 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0114"(x-ray crystallography) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16109942|imex:IM-24684-2|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:378-626 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:A5HZZ6 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0114"(x-ray crystallography) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16109942|imex:IM-24684-2|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:378-626 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:P09803 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-984420|uniprotkb:Q61377 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:"MI:0114"(x-ray crystallography) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16109942|imex:IM-24684-2|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:378-626 sufficient binding region:157-369 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:A5HZZ5 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110032|imex:IM-24684-3|dip:DIP-199457E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:B2WNtIwM6W6nJQU0iZ0lZRY0xVE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ6 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110032|imex:IM-24684-3|dip:DIP-199457E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:B2WNtIwM6W6nJQU0iZ0lZRY0xVE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ9 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109987|uniprotkb:A7G1U9 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:bxa1_clobh(display_long)|uniprotkb:botA(gene name)|psi-mi:botA(display_short)|uniprotkb:Bontoxilysin-A(gene name synonym)|uniprotkb:CBO0806(locus name)|uniprotkb:CLC_0862(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110032|imex:IM-24684-3|dip:DIP-199457E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N refseq:WP_011948511.1|refseq:YP_001253342.1|refseq:YP_001386738.1|rcsb pdb:1XTF|rcsb pdb:1XTG|rcsb pdb:2W2D|rcsb pdb:3DSE|rcsb pdb:3K3Q|rcsb pdb:3QIX|rcsb pdb:3QIY|rcsb pdb:3QIZ|rcsb pdb:3QJ0|rcsb pdb:3QW5|rcsb pdb:3QW6|rcsb pdb:3QW7|rcsb pdb:3QW8|rcsb pdb:4KS6|rcsb pdb:4KTX|rcsb pdb:4KUF|go:"GO:0005576"(extracellular region)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044156"(host cell junction)|go:"GO:0044231"(host cell presynaptic membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0090729"(toxin activity)|go:"GO:0008270"(zinc ion binding)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR011065(Kunitz inhibitor ST1-like)|interpro:IPR013104(Clostridium neurotoxin, receptor-binding C-terminal)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR012500(Clostridium neurotoxin, translocation)|dip:DIP-61682N|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|interpro:IPR036248|rcsb pdb:5L21 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:qVukrM7dCwSl1wRGSxewVWNvnQk441771 rigid:B2WNtIwM6W6nJQU0iZ0lZRY0xVE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:Q45914 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109965|ensemblbacteria:KON10585 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:bxan_clobo(display_long)|uniprotkb:ant(gene name)|psi-mi:ant(display_short)|uniprotkb:ntnh(gene name synonym)|uniprotkb:ACP52_06665(orf name)|uniprotkb:Botulinum neurotoxin type A non-toxic component(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:1491(clobo)|taxid:1491(Clostridium botulinum) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110032|imex:IM-24684-3|dip:DIP-199457E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N ensemblbacteria:ACP52_06665(gene)|ensemblbacteria:KON10585(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013677(Nontoxic nonhaemagglutinin C-terminal)|interpro:IPR036248|rcsb pdb:3V0A|rcsb pdb:3V0B|refseq:WP_011948510.1|dip:DIP-1006N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:xz0G9k34ijRY/ybFHCiCozWCJQE1491 rigid:B2WNtIwM6W6nJQU0iZ0lZRY0xVE false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ5 uniprotkb:A5HZZ4 intact:EBI-16109887|uniprotkb:A7G1U5 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0226"(ion exchange chromatography) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110052|imex:IM-24684-4|dip:DIP-199459E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:edZsSs5M8apj5Ug17K+PPiKu5hU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:A5HZZ5 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110069|imex:IM-24684-5|dip:DIP-199455E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:AOaUqUjghHE5nJiWkKvrRSVZDss false sufficient binding region:378-626|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ6 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110069|imex:IM-24684-5|dip:DIP-199455E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:AOaUqUjghHE5nJiWkKvrRSVZDss false sufficient binding region:378-626|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ6 uniprotkb:A5HZZ5 intact:EBI-16109874|uniprotkb:A7G1U6 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110091|imex:IM-24684-6|dip:DIP-199460E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:aW9pK3y4j3J5fMjl1/iQFmfL5n0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ5 uniprotkb:A5HZZ4 intact:EBI-16109887|uniprotkb:A7G1U5 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110108|imex:IM-24684-7|dip:DIP-199459E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:edZsSs5M8apj5Ug17K+PPiKu5hU false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09803 uniprotkb:A5HZZ4 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110127|imex:IM-24684-8|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:157-369|glutathione s tranferase tag:c-c - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P09803 uniprotkb:A5HZZ5 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110127|imex:IM-24684-8|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:157-369|glutathione s tranferase tag:c-c - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P09803 uniprotkb:A5HZZ6 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110127|imex:IM-24684-8|dip:DIP-199452E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:c3cqVihUUWWZocjPFQQNZvXpB/g false sufficient binding region:157-369|glutathione s tranferase tag:c-c - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ5 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110202|imex:IM-24684-11|dip:DIP-199455E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:AOaUqUjghHE5nJiWkKvrRSVZDss false sufficient binding region:378-626 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:A5HZZ6 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110202|imex:IM-24684-11|dip:DIP-199455E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:AOaUqUjghHE5nJiWkKvrRSVZDss false sufficient binding region:378-626 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09803 uniprotkb:A5HZZ4 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110167|imex:IM-24684-10|dip:DIP-199454E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:D0iMjuWGbsLxLxmKRL+8qcXWUYE false sufficient binding region:157-369|mutation disrupting interaction strength:170-170|mutation disrupting interaction strength:175-175|mutation disrupting interaction strength:176-176|mutation disrupting interaction strength:179-179 sufficient binding region:378-626|glutathione s tranferase tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q45914 uniprotkb:A5HZZ4 intact:EBI-16109965|ensemblbacteria:KON10585 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:bxan_clobo(display_long)|uniprotkb:ant(gene name)|psi-mi:ant(display_short)|uniprotkb:ntnh(gene name synonym)|uniprotkb:ACP52_06665(orf name)|uniprotkb:Botulinum neurotoxin type A non-toxic component(gene name synonym) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0226"(ion exchange chromatography) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:1491(clobo)|taxid:1491(Clostridium botulinum) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110150|imex:IM-24684-9|dip:DIP-199458E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:ACP52_06665(gene)|ensemblbacteria:KON10585(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013677(Nontoxic nonhaemagglutinin C-terminal)|interpro:IPR036248|rcsb pdb:3V0A|rcsb pdb:3V0B|refseq:WP_011948510.1|dip:DIP-1006N go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:xz0G9k34ijRY/ybFHCiCozWCJQE1491 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:SvbbNb/K6kJq4x4M7/YD8ZsJuW4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ6 uniprotkb:A5HZZ5 intact:EBI-16109874|uniprotkb:A7G1U6 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0226"(ion exchange chromatography) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110222|imex:IM-24684-12|dip:DIP-199460E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:aW9pK3y4j3J5fMjl1/iQFmfL5n0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ5 uniprotkb:A5HZZ4 intact:EBI-16109887|uniprotkb:A7G1U5 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110280|imex:IM-24684-15|dip:DIP-199459E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:edZsSs5M8apj5Ug17K+PPiKu5hU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09803 uniprotkb:A5HZZ4 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110258|imex:IM-24684-14|dip:DIP-199453E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:AugJHo84P5vq6PfWXv+nNGKFYbs false sufficient binding region:157-369|glutathione s tranferase tag:c-c - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P09803 uniprotkb:A5HZZ5 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16110258|imex:IM-24684-14|dip:DIP-199453E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:AugJHo84P5vq6PfWXv+nNGKFYbs false sufficient binding region:157-369|glutathione s tranferase tag:c-c - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q45914 uniprotkb:A5HZZ4 intact:EBI-16109965|ensemblbacteria:KON10585 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:bxan_clobo(display_long)|uniprotkb:ant(gene name)|psi-mi:ant(display_short)|uniprotkb:ntnh(gene name synonym)|uniprotkb:ACP52_06665(orf name)|uniprotkb:Botulinum neurotoxin type A non-toxic component(gene name synonym) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:1491(clobo)|taxid:1491(Clostridium botulinum) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110239|imex:IM-24684-13|dip:DIP-199458E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:ACP52_06665(gene)|ensemblbacteria:KON10585(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013677(Nontoxic nonhaemagglutinin C-terminal)|interpro:IPR036248|rcsb pdb:3V0A|rcsb pdb:3V0B|refseq:WP_011948510.1|dip:DIP-1006N go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:xz0G9k34ijRY/ybFHCiCozWCJQE1491 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:SvbbNb/K6kJq4x4M7/YD8ZsJuW4 false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q45914 uniprotkb:A5HZZ4 intact:EBI-16109965|ensemblbacteria:KON10585 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:bxan_clobo(display_long)|uniprotkb:ant(gene name)|psi-mi:ant(display_short)|uniprotkb:ntnh(gene name synonym)|uniprotkb:ACP52_06665(orf name)|uniprotkb:Botulinum neurotoxin type A non-toxic component(gene name synonym) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:1491(clobo)|taxid:1491(Clostridium botulinum) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16110297|imex:IM-24684-16|dip:DIP-199458E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblbacteria:ACP52_06665(gene)|ensemblbacteria:KON10585(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013677(Nontoxic nonhaemagglutinin C-terminal)|interpro:IPR036248|rcsb pdb:3V0A|rcsb pdb:3V0B|refseq:WP_011948510.1|dip:DIP-1006N go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:xz0G9k34ijRY/ybFHCiCozWCJQE1491 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:SvbbNb/K6kJq4x4M7/YD8ZsJuW4 false - - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ6 uniprotkb:A5HZZ5 intact:EBI-16109874|uniprotkb:A7G1U6 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110340|imex:IM-24684-18|dip:DIP-199460E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/08 2017/08/10 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:aW9pK3y4j3J5fMjl1/iQFmfL5n0 false - his tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P09803 uniprotkb:A5HZZ4 intact:EBI-984420|uniprotkb:Q61377 intact:EBI-16109901|uniprotkb:A7G1U4 psi-mi:cadh1_mouse(display_long)|uniprotkb:Epithelial cadherin(gene name synonym)|uniprotkb:Uvomorulin(gene name synonym)|uniprotkb:ARC-1(gene name synonym)|uniprotkb:Cdh1(gene name)|psi-mi:Cdh1(display_short) psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:"MI:0096"(pull down) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110314|imex:IM-24684-17|dip:DIP-199454E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001701"(in utero embryonic development)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007566"(embryo implantation)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016600"(flotillin complex)|go:"GO:0019538"(protein metabolic process)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035847"(uterine epithelium development)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0090102"(cochlea development)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|go:"GO:0043679"(axon terminus)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045177"(apical part of cell)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0060662"(salivary gland cavitation)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030049|interpro:IPR039808|rcsb pdb:1EDH|rcsb pdb:1FF5|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1Q1P|rcsb pdb:1SUH|rcsb pdb:2OMW|rcsb pdb:2QVF|rcsb pdb:3IFQ|rcsb pdb:3LNE|interpro:IPR015919(Cadherin-like)|rcsb pdb:3LNF|rcsb pdb:3LNG|rcsb pdb:3LNH|rcsb pdb:3LNI|rcsb pdb:3Q2L|rcsb pdb:3Q2N|rcsb pdb:3Q2V|rcsb pdb:3QRB|rcsb pdb:4QD2|rcsb pdb:7AR4|reactome:R-MMU-1474228|reactome:R-MMU-216083|reactome:R-MMU-351906|reactome:R-MMU-418990|reactome:R-MMU-5626467|refseq:NP_033994.1|dip:DIP-29635N|mint:P09803 go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:VC5bbvNrxRzOFvwFCr/+CS2cSG410090 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rigid:D0iMjuWGbsLxLxmKRL+8qcXWUYE false sufficient binding region:157-369 sufficient binding region:378-626|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:505-505 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:A5HZZ4 uniprotkb:A5HZZ5 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109887|uniprotkb:A7G1U5 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz5_clobh(display_long)|uniprotkb:ha17(gene name)|psi-mi:ha17(display_short)|uniprotkb:CBO0802(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110359|imex:IM-24684-19|dip:DIP-199456E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR008903(HA-17, Clostridium botulinum)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_003356711.1|refseq:YP_001253338.1|refseq:YP_001386734.1|dip:DIP-61680N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:s3bDHwrq88rF82F43t1vYbdFyoQ441771 rigid:8cBccqWxILZyzyTBgha+DpapvDU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:A5HZZ6 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109874|uniprotkb:A7G1U6 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:a5hzz6_clobh(display_long)|uniprotkb:ha33(gene name)|psi-mi:ha33(display_short)|uniprotkb:CBO0803(locus name) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110359|imex:IM-24684-19|dip:DIP-199456E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N interpro:IPR000772(Ricin B lectin)|interpro:IPR035992|rcsb pdb:4QD2|refseq:WP_011948508.1|refseq:YP_001253339.1|refseq:YP_001386735.1|dip:DIP-61679N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:S+YbYwSzNsoJZTmmDI1RXsS19OY441771 rigid:8cBccqWxILZyzyTBgha+DpapvDU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A5HZZ4 uniprotkb:Q45914 intact:EBI-16109901|uniprotkb:A7G1U4 intact:EBI-16109965|ensemblbacteria:KON10585 psi-mi:a5hzz4_clobh(display_long)|uniprotkb:ha70(gene name)|psi-mi:ha70(display_short)|uniprotkb:CBO0801(locus name) psi-mi:bxan_clobo(display_long)|uniprotkb:ant(gene name)|psi-mi:ant(display_short)|uniprotkb:ntnh(gene name synonym)|uniprotkb:ACP52_06665(orf name)|uniprotkb:Botulinum neurotoxin type A non-toxic component(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Lee et al. (2014) pubmed:24948737|doi:10.1126/science.1253823|imex:IM-24684 taxid:441771(clobh)|taxid:441771("Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)") taxid:1491(clobo)|taxid:1491(Clostridium botulinum) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16110359|imex:IM-24684-19|dip:DIP-199456E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005576"(extracellular region)|interpro:IPR003897(Clostridium enterotoxin)|interpro:IPR040597|rcsb pdb:4QD2|refseq:WP_011948507.1|refseq:YP_001253337.1|refseq:YP_001386733.1|dip:DIP-61681N ensemblbacteria:ACP52_06665(gene)|ensemblbacteria:KON10585(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008270"(zinc ion binding)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|interpro:IPR000395(Peptidase M27, bontoxilysin)|interpro:IPR012928(Clostridium neurotoxin, receptor binding N-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013677(Nontoxic nonhaemagglutinin C-terminal)|interpro:IPR036248|rcsb pdb:3V0A|rcsb pdb:3V0B|refseq:WP_011948510.1|dip:DIP-1006N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/08 2017/08/10 rogid:y2XniR0vMzyIB2M5LnFrfAG3+b0441771 rogid:xz0G9k34ijRY/ybFHCiCozWCJQE1491 rigid:8cBccqWxILZyzyTBgha+DpapvDU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)