#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q93034 uniprotkb:Q13951 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0071"(molecular sieving) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089259|imex:IM-22358-1|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:Q15369-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089259|imex:IM-22358-1|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:17-112 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:Q15370-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0071"(molecular sieving) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089259|imex:IM-22358-1|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:1-102 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:P12504 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-779991 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0071"(molecular sieving) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089259|imex:IM-22358-1|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:P12504 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-779991 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089316|imex:IM-22358-3|dip:DIP-195899E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:qujPPRFDNPBxkV9zHEwIlrp+duY false sufficient binding region:12-386|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:Q13951 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089316|imex:IM-22358-3|dip:DIP-195899E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:qujPPRFDNPBxkV9zHEwIlrp+duY false sufficient binding region:12-386|glutathione s tranferase tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:Q13951 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0114"(x-ray crystallography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089288|imex:IM-22358-2|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:1-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:Q15369-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089288|imex:IM-22358-2|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:17-112 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:Q15370-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089288|imex:IM-22358-2|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:1-102 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:P12504 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-779991 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0114"(x-ray crystallography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16089288|imex:IM-22358-2|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:Q13951 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089340|imex:IM-22358-4|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:1-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:Q15369-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089340|imex:IM-22358-4|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:17-112 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:Q15370-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089340|imex:IM-22358-4|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 sufficient binding region:1-102 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:P12504 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-779991 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089340|imex:IM-22358-4|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q93034 uniprotkb:Q15369-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089368|imex:IM-22358-5|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386|glutathione s tranferase tag:n-n sufficient binding region:17-112 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:Q15370-1 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089368|imex:IM-22358-5|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386|glutathione s tranferase tag:n-n sufficient binding region:1-102 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:P12504 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-779991 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089368|imex:IM-22358-5|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q93034 uniprotkb:Q13951 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089368|imex:IM-22358-5|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false sufficient binding region:12-386|glutathione s tranferase tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q13951 uniprotkb:Q15369-1 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089398|imex:IM-22358-6|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false sufficient binding region:1-170 sufficient binding region:17-112 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13951 uniprotkb:Q15370-1 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089398|imex:IM-22358-6|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false sufficient binding region:1-170 sufficient binding region:1-102 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q13951 uniprotkb:P12504 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 intact:EBI-779991 psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0226"(ion exchange chromatography) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089398|imex:IM-22358-6|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false sufficient binding region:1-170 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P12504 uniprotkb:Q15369-1 intact:EBI-779991 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089423|imex:IM-22358-7|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false his tag:n-n sufficient binding region:17-112|glutathione s tranferase tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q15370-1 intact:EBI-779991 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089423|imex:IM-22358-7|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false his tag:n-n sufficient binding region:1-102 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089423|imex:IM-22358-7|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false his tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q13617 intact:EBI-779991 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089508|imex:IM-22358-10|dip:DIP-195900E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 rigid:IIjiZhMT7quxTVVKayttTBa6D2A false his tag:n-n sufficient binding region:1-379|glutathione s tranferase tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q15369-1 intact:EBI-779991 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089508|imex:IM-22358-10|dip:DIP-195900E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:IIjiZhMT7quxTVVKayttTBa6D2A false his tag:n-n sufficient binding region:17-112 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q15370-1 intact:EBI-779991 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089508|imex:IM-22358-10|dip:DIP-195900E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:IIjiZhMT7quxTVVKayttTBa6D2A false his tag:n-n sufficient binding region:1-102 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089508|imex:IM-22358-10|dip:DIP-195900E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:IIjiZhMT7quxTVVKayttTBa6D2A false his tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q15369-1 intact:EBI-779991 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089481|imex:IM-22358-9|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false his tag:n-n sufficient binding region:17-112 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P12504 uniprotkb:Q15370-1 intact:EBI-779991 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089481|imex:IM-22358-9|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false his tag:n-n sufficient binding region:1-102 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089481|imex:IM-22358-9|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:562(ecolx)|taxid:562(Escherichia coli) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false his tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q15369-1 uniprotkb:Q15370-1 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089452|imex:IM-22358-8|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false sufficient binding region:17-112|glutathione s tranferase tag:n-n sufficient binding region:1-102 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q15369-1 uniprotkb:P12504 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 intact:EBI-779991 psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089452|imex:IM-22358-8|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false sufficient binding region:17-112|glutathione s tranferase tag:n-n his tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:Q15369-1 uniprotkb:Q13951 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089452|imex:IM-22358-8|dip:DIP-195901E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:Dvd75XmEqxmCggAbqi2yRLhe4Uw false sufficient binding region:17-112|glutathione s tranferase tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q15369-1 intact:EBI-779991 intact:EBI-15581843|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15369-1(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089540|imex:IM-22358-11|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|ensembl:ENST00000622804(transcript)|intact:EBI-301231(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false his tag:n-n sufficient binding region:17-112 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q15370-1 intact:EBI-779991 intact:EBI-15581828|ensembl:ENSP00000386652 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:q15370-1(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089540|imex:IM-22358-11|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|intact:EBI-301238(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false his tag:n-n sufficient binding region:1-102 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q93034 intact:EBI-779991 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089540|imex:IM-22358-11|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false his tag:n-n sufficient binding region:12-386|glutathione s tranferase tag:n-n - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:P12504 uniprotkb:Q13951 intact:EBI-779991 intact:EBI-718750|uniprotkb:Q13124|uniprotkb:Q9HCT2|uniprotkb:A8K347|ensembl:ENSP00000290858 psi-mi:vif_hv1n5(display_long)|uniprotkb:SOR protein(gene name synonym)|uniprotkb:vif(gene name)|psi-mi:vif(display_short) psi-mi:pebb_human(display_long)|uniprotkb:Polyomavirus enhancer-binding protein 2 beta subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 subunit beta(gene name synonym)|uniprotkb:SL3/AKV core-binding factor beta subunit(gene name synonym)|uniprotkb:CBFB(gene name)|psi-mi:CBFB(display_short) psi-mi:"MI:0096"(pull down) Guo et al. (2014) pubmed:24402281|doi:10.1038/nature12884|imex:IM-22358 taxid:11698(hv1n5)|taxid:11698("Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-16089540|imex:IM-22358-11|dip:DIP-195898E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-36069N|go:"GO:0003723"(RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019058"(viral life cycle)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|interpro:IPR000475("Retroviral Vif (Viral infectivity) protein")|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:4N9F|rcsb pdb:6NIL refseq:NP_001746.1|refseq:NP_074036.1|dip:DIP-36772N|ensembl:ENSG00000067955(gene)|ensembl:ENST00000290858(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0016513"(core-binding factor complex)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043378"(positive regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0060216"(definitive hemopoiesis)|interpro:IPR003417(Core binding factor, beta subunit)|interpro:IPR036552|mint:Q13951|rcsb pdb:1CL3|rcsb pdb:1E50|rcsb pdb:1H9D|rcsb pdb:4N9F|rcsb pdb:6NIL|rcsb pdb:6P59|rcsb pdb:6VGD|rcsb pdb:6VGE|rcsb pdb:6VGG|reactome:R-HSA-8877330|reactome:R-HSA-8878166|reactome:R-HSA-8931987|reactome:R-HSA-8934593|go:"GO:0030098"(lymphocyte differentiation)|go:"GO:0030099"(myeloid cell differentiation)|reactome:R-HSA-8935964|reactome:R-HSA-8936459|reactome:R-HSA-8941332|reactome:R-HSA-8941333|reactome:R-HSA-8941858|reactome:R-HSA-8949275|reactome:R-HSA-8951911|reactome:R-HSA-8951936|reactome:R-HSA-9018519|reactome:R-HSA-9616222|reactome:R-HSA-8939236|reactome:R-HSA-8939242|reactome:R-HSA-8939243|reactome:R-HSA-8939245|reactome:R-HSA-8939246|reactome:R-HSA-8939247|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:H/Ja1HuLpE2b8ly9aKuonp+exC011698 rogid:CPjRPRBOYrP/Oj+k66XpWQysihY9606 rigid:RKEqiF6v24CYZ0NhHUwLZ2uweng false his tag:n-n sufficient binding region:1-170 - - psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)