#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14965	uniprotkb:O95067	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-375024|uniprotkb:Q6FI99|uniprotkb:B3KM93|ensembl:ENSP00000288207	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:ccnb2_human(display_long)|uniprotkb:CCNB2(gene name)|psi-mi:CCNB2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_004692.1|ensembl:ENSG00000157456(gene)|ensembl:ENST00000288207(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040008"(regulation of growth)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045296"(cadherin binding)|go:"GO:0048538"(thymus development)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:O95067|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-8852276|dip:DIP-31730N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:7ztz22HOOgNq/6KO1iXhGT3tb+A9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:O96020	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:P06493	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:P24941	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:P46527	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:Q92841	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-746012|uniprotkb:Q69YT1|uniprotkb:Q6ICD6|uniprotkb:H3BLZ8|uniprotkb:B1AHM0|ensembl:ENSP00000385536	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:ddx17_human(display_long)|uniprotkb:DEAD box protein 17(gene name synonym)|uniprotkb:RNA-dependent helicase p72(gene name synonym)|uniprotkb:DEAD box protein p72(gene name synonym)|uniprotkb:DDX17(gene name)|psi-mi:DDX17(display_short)|uniprotkb:DEAD box protein p82(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_006377.2|ensembl:ENSG00000100201(gene)|ensembl:ENST00000403230(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006364"(rRNA processing)|go:"GO:0006396"(RNA processing)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q92841|rcsb pdb:6UV0|rcsb pdb:6UV1|rcsb pdb:6UV2|rcsb pdb:6UV3|rcsb pdb:6UV4|reactome:R-HSA-3899300|dip:DIP-29843N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:3UhUuhRSZg/zlM7UPDKYCqNmUho9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:Q14103	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-299674|ensembl:ENSP00000313199|uniprotkb:P07029|uniprotkb:Q01858|uniprotkb:Q14100|uniprotkb:Q14101|uniprotkb:Q14102|uniprotkb:Q4W5A1|uniprotkb:A8K9J2|uniprotkb:Q9UCE8|uniprotkb:Q9UCE9	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:hnrpd_human(display_long)|uniprotkb:HNRNPD(gene name)|psi-mi:HNRNPD(display_short)|uniprotkb:AUF1(gene name synonym)|uniprotkb:HNRPD(gene name synonym)|uniprotkb:AU-rich element RNA-binding protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENSG00000138668(gene)|ensembl:ENST00000313899(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006396"(RNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097167"(circadian regulation of translation)|go:"GO:1901355"(response to rapamycin)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904383"(response to sodium phosphate)|go:"GO:1904586"(cellular response to putrescine)|go:"GO:1905663"(positive regulation of telomerase RNA reverse transcriptase activity)|go:"GO:1990828"(hepatocyte dedifferentiation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012956(CBF, N-terminal)|interpro:IPR035979|mint:Q14103|rcsb pdb:1HD0|rcsb pdb:1HD1|rcsb pdb:1IQT|rcsb pdb:1WTB|rcsb pdb:1X0F|rcsb pdb:2Z5N|rcsb pdb:5IM0|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|reactome:R-HSA-450408|reactome:R-HSA-72163|reactome:R-HSA-72203|refseq:NP_001003810.1|refseq:NP_002129.2|refseq:NP_112737.1|refseq:NP_112738.1|dip:DIP-31163N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:LrC0nOpN6jGn3WELs5NEOccNPnw9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:Q15233	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-350527|ensembl:ENSP00000503233|uniprotkb:O00201|uniprotkb:P30807|uniprotkb:Q12786|uniprotkb:Q9BQC5|ensembl:ENSP00000276079|ensembl:ENSP00000362947|ensembl:ENSP00000406673|ensembl:ENSP00000410299|ensembl:ENSP00000415777|ensembl:ENSP00000503031|ensembl:ENSP00000504314|ensembl:ENSP00000504351|uniprotkb:D3DVV4|uniprotkb:B7Z4C2|uniprotkb:F5GYZ3	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:nono_human(display_long)|uniprotkb:NONO(gene name)|psi-mi:NONO(display_short)|uniprotkb:NRB54(gene name synonym)|uniprotkb:54 kDa nuclear RNA- and DNA-binding protein(gene name synonym)|uniprotkb:"p54(nrb)"(gene name synonym)|uniprotkb:55 kDa nuclear protein(gene name synonym)|uniprotkb:NMT55(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 52 kDa subunit(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:NP_001138880.1|refseq:NP_001138881.1|refseq:NP_001138882.1|refseq:NP_031389.3|ensembl:ENSG00000147140(gene)|ensembl:ENST00000276079(transcript)|ensembl:ENST00000373841(transcript)|ensembl:ENST00000420903(transcript)|ensembl:ENST00000450092(transcript)|ensembl:ENST00000454976(transcript)|ensembl:ENST00000677274(transcript)|ensembl:ENST00000677446(transcript)|ensembl:ENST00000677612(transcript)|ensembl:ENST00000678231(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006397"(mRNA processing)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034552|interpro:IPR035979|mint:Q15233|rcsb pdb:3SDE|rcsb pdb:5IFM|rcsb pdb:6WMZ|rcsb pdb:7LRQ|dip:DIP-29951N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:5W3ooO4h0qh3GKO+WjDrLBhihHA9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:Q9UQR0	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:Q9UHD8	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-851542|uniprotkb:Q96QF3|uniprotkb:Q96QF4|uniprotkb:Q96QF5|uniprotkb:Q9HA04|uniprotkb:Q9UG40|uniprotkb:Q9Y5W4|uniprotkb:A8K2V3|uniprotkb:B3KPM0|uniprotkb:B4DTL9|uniprotkb:B4E0N2|uniprotkb:B4E274|uniprotkb:B7Z654|ensembl:ENSP00000391249	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:sept9_human(display_long)|uniprotkb:SEPTIN9(gene name)|psi-mi:SEPTIN9(display_short)|uniprotkb:KIAA0991(gene name synonym)|uniprotkb:MLL septin-like fusion protein MSF-A(gene name synonym)|uniprotkb:MSF(gene name synonym)|uniprotkb:Ovarian/Breast septin(gene name synonym)|uniprotkb:SEPT9(gene name synonym)|uniprotkb:Septin D1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	refseq:XP_006721706.1|refseq:XP_006721707.1|refseq:NP_001106963.1|refseq:NP_001106964.1|refseq:NP_001106965.1|refseq:NP_001106966.1|refseq:NP_001106967.1|refseq:NP_001106968.1|refseq:NP_006631.2|refseq:XP_016879520.1|refseq:XP_016879521.1|refseq:NP_001280624.1|refseq:NP_001280625.1|refseq:NP_001280626.1|refseq:NP_001280627.1|refseq:XP_011522509.1|refseq:XP_011522510.1|refseq:XP_005257019.1|dip:DIP-36697N|ensembl:ENSG00000184640(gene)|ensembl:ENST00000427177(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005930"(axoneme)|go:"GO:0005940"(septin ring)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0031105"(septin complex)|go:"GO:0032153"(cell division site)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0097730"(non-motile cilium)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030645|mint:Q9UHD8|rcsb pdb:4YQF|rcsb pdb:5CYO|rcsb pdb:5CYP	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:YzUn6hS5tAX/U+SJ8YzqzWW/dQI9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O14965	uniprotkb:Q9Y6I4	intact:EBI-448680|uniprotkb:O60445|uniprotkb:O75873|uniprotkb:Q9BQD6|uniprotkb:Q9UPG5|uniprotkb:E1P5F9|ensembl:ENSP00000216911|ensembl:ENSP00000321591|ensembl:ENSP00000360407|ensembl:ENSP00000379247|ensembl:ENSP00000379249|ensembl:ENSP00000379250|ensembl:ENSP00000379251	intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6	psi-mi:aurka_human(display_long)|uniprotkb:AIRK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 15(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 1(gene name synonym)|uniprotkb:Breast tumor-amplified kinase(gene name synonym)|uniprotkb:STK6(gene name synonym)|uniprotkb:AIK(gene name synonym)|uniprotkb:ARK1(gene name synonym)|uniprotkb:AURA(gene name synonym)|uniprotkb:BTAK(gene name synonym)|uniprotkb:STK15(gene name synonym)|uniprotkb:AURKA(gene name)|psi-mi:AURKA(display_short)|uniprotkb:AYK1(gene name synonym)|uniprotkb:IAK1(gene name synonym)|uniprotkb:Aurora 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 6(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-A(gene name synonym)	psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16086991|imex:IM-22343-1|dip:DIP-195848E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003591.2|refseq:NP_940835.1|refseq:NP_940836.1|refseq:NP_940837.1|refseq:NP_940838.1|refseq:NP_940839.1|refseq:NP_001310232.1|refseq:NP_001310233.1|refseq:NP_001310234.1|refseq:XP_016883524.1|dip:DIP-33068N|rcsb pdb:3LAU|rcsb pdb:3M11|rcsb pdb:3MYG|rcsb pdb:3NRM|rcsb pdb:3O50|rcsb pdb:3O51|rcsb pdb:3P9J|rcsb pdb:3QBN|rcsb pdb:3R21|rcsb pdb:3R22|rcsb pdb:3UNZ|rcsb pdb:3UO4|rcsb pdb:3UO5|rcsb pdb:3UO6|rcsb pdb:3UOD|rcsb pdb:3UOH|rcsb pdb:3UOJ|rcsb pdb:3UOK|rcsb pdb:3UOL|rcsb pdb:3UP2|rcsb pdb:3UP7|rcsb pdb:3W10|rcsb pdb:3W16|rcsb pdb:3W18|rcsb pdb:3W2C|rcsb pdb:4B0G|rcsb pdb:4BN1|rcsb pdb:4BYI|rcsb pdb:4BYJ|rcsb pdb:4C3P|rcsb pdb:4C3R|rcsb pdb:4CEG|rcsb pdb:4DEA|rcsb pdb:4DEB|rcsb pdb:4DED|rcsb pdb:4DEE|rcsb pdb:4DHF|rcsb pdb:4J8M|rcsb pdb:4J8N|rcsb pdb:4JAI|rcsb pdb:4JAJ|rcsb pdb:4JBO|rcsb pdb:4JBP|rcsb pdb:4JBQ|rcsb pdb:4O0S|rcsb pdb:4O0U|rcsb pdb:4O0W|rcsb pdb:4PRJ|rcsb pdb:4UYN|rcsb pdb:4UZD|rcsb pdb:4UZH|rcsb pdb:4ZS0|rcsb pdb:3VAP|rcsb pdb:4ZTQ|rcsb pdb:4ZTR|rcsb pdb:5AAD|rcsb pdb:5AAE|rcsb pdb:5AAF|rcsb pdb:5AAG|rcsb pdb:5DN3|rcsb pdb:5DNR|rcsb pdb:5DOS|rcsb pdb:5DPV|rcsb pdb:5DR2|rcsb pdb:5DR6|rcsb pdb:5DR9|rcsb pdb:5DRD|rcsb pdb:5DT0|rcsb pdb:5DT3|rcsb pdb:5DT4|rcsb pdb:5EW9|rcsb pdb:5G15|rcsb pdb:5G1X|rcsb pdb:5L8J|rcsb pdb:5L8K|rcsb pdb:5L8L|rcsb pdb:5LXM|rcsb pdb:5OBJ|rcsb pdb:5OBR|rcsb pdb:5ODT|rcsb pdb:5ONE|rcsb pdb:5ORL|rcsb pdb:5ORN|rcsb pdb:5ORO|rcsb pdb:5ORP|rcsb pdb:5ORR|rcsb pdb:5ORS|rcsb pdb:5ORT|rcsb pdb:5ORV|rcsb pdb:5ORW|rcsb pdb:5ORX|rcsb pdb:5ORY|rcsb pdb:5ORZ|rcsb pdb:5OS0|rcsb pdb:5OS1|rcsb pdb:5OS2|rcsb pdb:5OS3|rcsb pdb:5OS4|rcsb pdb:5OS5|rcsb pdb:5OS6|rcsb pdb:5OSD|rcsb pdb:5OSE|rcsb pdb:5OSF|rcsb pdb:5ZAN|rcsb pdb:6C2R|rcsb pdb:6C2T|rcsb pdb:6C83|rcsb pdb:6CPE|rcsb pdb:6CPF|rcsb pdb:6CPG|rcsb pdb:6GRA|rcsb pdb:6HJJ|rcsb pdb:6HJK|rcsb pdb:6I2U|rcsb pdb:6R49|rcsb pdb:6R4A|rcsb pdb:6R4B|rcsb pdb:4ZTS|rcsb pdb:6R4C|rcsb pdb:6R4D|rcsb pdb:6VPG|rcsb pdb:6VPH|rcsb pdb:6VPI|rcsb pdb:6VPJ|rcsb pdb:6VPL|rcsb pdb:6VPM|rcsb pdb:6XKA|rcsb pdb:6Z4Y|rcsb pdb:7AYH|rcsb pdb:7AYI|reactome:R-HSA-174178|reactome:R-HSA-2565942|reactome:R-HSA-4615885|reactome:R-HSA-6804114|reactome:R-HSA-6804756|reactome:R-HSA-8854050|reactome:R-HSA-8854518|reactome:R-HSA-8854521|ensembl:ENSG00000087586(gene)|ensembl:ENST00000312783(transcript)|ensembl:ENST00000347343(transcript)|ensembl:ENST00000371356(transcript)|ensembl:ENST00000395911(transcript)|ensembl:ENST00000395913(transcript)|ensembl:ENST00000395914(transcript)|ensembl:ENST00000395915(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0009611"(response to wounding)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0042585"(germinal vesicle)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0045120"(pronucleus)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051642"(centrosome localization)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0072687"(meiotic spindle)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097421"(liver regeneration)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900195"(positive regulation of oocyte maturation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2C6D|rcsb pdb:2C6E|rcsb pdb:2DWB|rcsb pdb:2J4Z|rcsb pdb:2J50|rcsb pdb:2NP8|rcsb pdb:2W1C|rcsb pdb:2W1D|rcsb pdb:2W1E|rcsb pdb:2W1F|interpro:IPR030611|rcsb pdb:2W1G|rcsb pdb:2WQE|rcsb pdb:2WTV|rcsb pdb:2WTW|rcsb pdb:2X6D|rcsb pdb:2X6E|rcsb pdb:2X81|rcsb pdb:2XNE|rcsb pdb:2XNG|rcsb pdb:2XRU|rcsb pdb:3COH|rcsb pdb:3E5A|rcsb pdb:3EFW|rcsb pdb:3FDN|interpro:IPR030616|mint:O14965|rcsb pdb:1MQ4|rcsb pdb:1MUO|rcsb pdb:1OL5|rcsb pdb:1OL6|rcsb pdb:1OL7|rcsb pdb:2BMC|rcsb pdb:3H0Y|rcsb pdb:3H0Z|rcsb pdb:3H10|rcsb pdb:3HA6|rcsb pdb:3K5U	ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:UT4ih1hMN2xMvAC3hDznAJOW+/E9606	rogid:036gyrDoXUao0ijci4SkCcYBAAE9606	rigid:N2TdJEf6rEVHM0DAe8+ljsch3bY	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P20248	uniprotkb:P24941	intact:EBI-457097|ensembl:ENSP00000274026|uniprotkb:Q2M3U6|uniprotkb:Q4W5P4|uniprotkb:Q6LER8|uniprotkb:A8K7B6	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:ccna2_human(display_long)|uniprotkb:Cyclin A(gene name synonym)|uniprotkb:CCNA2(gene name)|psi-mi:CCNA2(display_short)|uniprotkb:CCN1(gene name synonym)|uniprotkb:CCNA(gene name synonym)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087018|imex:IM-22343-2|dip:DIP-551E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000145386(gene)|ensembl:ENST00000274026(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|refseq:NP_001228.1|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|mint:P20248|rcsb pdb:1E9H|rcsb pdb:1FIN|rcsb pdb:1H1P|rcsb pdb:1FVV|rcsb pdb:1GY3|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P5E|rcsb pdb:1PKD|rcsb pdb:1QMZ|rcsb pdb:1URC|rcsb pdb:1VYW|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2C4G|rcsb pdb:6SG4|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7LUO|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:2CJM|rcsb pdb:2WIH|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2UUE|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3F5X|rcsb pdb:4BCK|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2V22|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCP|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:6Q6H|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4FX3|rcsb pdb:5CYI|rcsb pdb:5IF1|rcsb pdb:5LMK|rcsb pdb:5NEV|rcsb pdb:6ATH|rcsb pdb:6RIJ|rcsb pdb:6GVA|rcsb pdb:6P3W|rcsb pdb:6Q6G|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|dip:DIP-638N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:eAkF93loT7w//7jrIC/Nlpy5iVc9606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:yl+/T8feRbKEGrXNAYqwGuVgGRk	false	his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P24941	uniprotkb:Q9UQR0-1	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-16087037|ensembl:ENSP00000251900	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087044|imex:IM-22343-3|dip:DIP-195852E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:NtoA9neUsTUme8z6nWMk4fxVpLI	false	-	sufficient binding region:1-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24941	uniprotkb:P38936	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087044|imex:IM-22343-3|dip:DIP-195852E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:NtoA9neUsTUme8z6nWMk4fxVpLI	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P14635	uniprotkb:P06493	intact:EBI-495332|uniprotkb:A8K066|uniprotkb:Q5TZP9|ensembl:ENSP00000256442	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	psi-mi:ccnb1_human(display_long)|uniprotkb:CCNB1(gene name)|psi-mi:CCNB1(display_short)|uniprotkb:CCNB(gene name synonym)	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087066|imex:IM-22343-4|dip:DIP-1120E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114172.1|dip:DIP-59N|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046680"(response to DDT)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048565"(digestive tract development)|go:"GO:0051301"(cell division)|go:"GO:0051987"(positive regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060623"(regulation of chromosome condensation)|ensembl:ENSG00000134057(gene)|ensembl:ENST00000256442(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005113"(patched binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|go:"GO:2000775"(obsolete histone H3-S10 phosphorylation involved in chromosome condensation)|interpro:IPR004367(Cyclin, C-terminal)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071283"("cellular response to iron(III) ion")|interpro:IPR039361|mint:P14635|rcsb pdb:2B9R|rcsb pdb:2JGZ|rcsb pdb:4Y72|rcsb pdb:4YC3|go:"GO:0071398"(cellular response to fatty acid)|rcsb pdb:5HQ0|go:"GO:0071407"(cellular response to organic cyclic compound)|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|reactome:R-HSA-113507|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174048|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|go:"GO:0071456"(cellular response to hypoxia)|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-4419969|reactome:R-HSA-6804114|reactome:R-HSA-68875|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8878166|reactome:R-HSA-8852276	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:WCQWqI2kWZfatq4L2DC0hm26Ix09606	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	rigid:/8HlDX9X8DZj6bcwlH+UXzILPzY	false	his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P38936	uniprotkb:P24941	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087085|imex:IM-22343-5|dip:DIP-61185E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:H5T8DN9s3gCfTFr8rCYEIYYFx3o	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UQR0-1	uniprotkb:P38936	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087102|imex:IM-22343-6|dip:DIP-195851E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:Dtrsqk4xjNhABCZhv1qB230Pvdo	false	sufficient binding region:1-300	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0817"(molecular weight estimation by silver staining)	psi-mi:"MI:0817"(molecular weight estimation by silver staining)
uniprotkb:Q9UQR0-1	uniprotkb:P24941	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087123|imex:IM-22343-7|dip:DIP-195850E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:R+JQN7YvcxWGLVpFeKR8cjPmsLs	false	sufficient binding region:1-609	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQR0-1	uniprotkb:P46527	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087142|imex:IM-22343-8|dip:DIP-195853E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:CKWESbvGzUtu9/Z94zaEpsx5HM0	false	sufficient binding region:1-609	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQR0-1	uniprotkb:P24941	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087142|imex:IM-22343-8|dip:DIP-195853E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:CKWESbvGzUtu9/Z94zaEpsx5HM0	false	sufficient binding region:1-609	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQR0-1	uniprotkb:P24941	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087181|imex:IM-22343-10|dip:DIP-195850E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:R+JQN7YvcxWGLVpFeKR8cjPmsLs	false	sufficient binding region:1-609	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24941	uniprotkb:P38936	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087162|imex:IM-22343-9|dip:DIP-61185E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:H5T8DN9s3gCfTFr8rCYEIYYFx3o	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24864	uniprotkb:P24941	intact:EBI-519526|uniprotkb:Q14091|uniprotkb:Q8NFG1|uniprotkb:Q92501|ensembl:ENSP00000262643|uniprotkb:A8K684|uniprotkb:Q9UD21	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:ccne1_human(display_long)|uniprotkb:CCNE1(gene name)|psi-mi:CCNE1(display_short)|uniprotkb:CCNE(gene name synonym)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087200|imex:IM-22343-11|dip:DIP-63227E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000105173(gene)|ensembl:ENST00000262643(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:P24864|rcsb pdb:1W98|rcsb pdb:5L2W|rcsb pdb:7KJS|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69205|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-8849470|reactome:R-HSA-9661069|reactome:R-HSA-9706019|refseq:NP_001229.1|refseq:NP_001309191.1|dip:DIP-149N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr)|taxid:7108("Spodoptera frugiperda (Fall armyworm)")	-	2017/08/07	2017/08/10	rogid:IAmpLalK9y8siqmQgbDtQAgsxC09606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:DeX/F2SoKGfkMNV2e/YMqhOsc3g	false	his tag:n-n	-	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P24941	uniprotkb:Q9UQR0	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087258|imex:IM-22343-14|dip:DIP-195850E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:R+JQN7YvcxWGLVpFeKR8cjPmsLs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24941	uniprotkb:P38936	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087239|imex:IM-22343-13|dip:DIP-61185E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:H5T8DN9s3gCfTFr8rCYEIYYFx3o	false	-	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95067	uniprotkb:O96020	intact:EBI-375024|uniprotkb:Q6FI99|uniprotkb:B3KM93|ensembl:ENSP00000288207	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	psi-mi:ccnb2_human(display_long)|uniprotkb:CCNB2(gene name)|psi-mi:CCNB2(display_short)	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087219|imex:IM-22343-12|dip:DIP-195849E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004692.1|ensembl:ENSG00000157456(gene)|ensembl:ENST00000288207(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040008"(regulation of growth)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045296"(cadherin binding)|go:"GO:0048538"(thymus development)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:O95067|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-8852276|dip:DIP-31730N	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:7ztz22HOOgNq/6KO1iXhGT3tb+A9606	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rigid:eR5KD0JtxC+21uHo9Y/CB+FpApM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95067	uniprotkb:P24941	intact:EBI-375024|uniprotkb:Q6FI99|uniprotkb:B3KM93|ensembl:ENSP00000288207	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:ccnb2_human(display_long)|uniprotkb:CCNB2(gene name)|psi-mi:CCNB2(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087219|imex:IM-22343-12|dip:DIP-195849E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004692.1|ensembl:ENSG00000157456(gene)|ensembl:ENST00000288207(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040008"(regulation of growth)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045296"(cadherin binding)|go:"GO:0048538"(thymus development)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:O95067|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-8852276|dip:DIP-31730N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:7ztz22HOOgNq/6KO1iXhGT3tb+A9606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:eR5KD0JtxC+21uHo9Y/CB+FpApM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95067	uniprotkb:P46527	intact:EBI-375024|uniprotkb:Q6FI99|uniprotkb:B3KM93|ensembl:ENSP00000288207	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:ccnb2_human(display_long)|uniprotkb:CCNB2(gene name)|psi-mi:CCNB2(display_short)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087219|imex:IM-22343-12|dip:DIP-195849E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004692.1|ensembl:ENSG00000157456(gene)|ensembl:ENST00000288207(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040008"(regulation of growth)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045296"(cadherin binding)|go:"GO:0048538"(thymus development)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:O95067|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-8852276|dip:DIP-31730N	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:7ztz22HOOgNq/6KO1iXhGT3tb+A9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:eR5KD0JtxC+21uHo9Y/CB+FpApM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95067	uniprotkb:Q9UQR0	intact:EBI-375024|uniprotkb:Q6FI99|uniprotkb:B3KM93|ensembl:ENSP00000288207	intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6	psi-mi:ccnb2_human(display_long)|uniprotkb:CCNB2(gene name)|psi-mi:CCNB2(display_short)	psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087219|imex:IM-22343-12|dip:DIP-195849E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004692.1|ensembl:ENSG00000157456(gene)|ensembl:ENST00000288207(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0040008"(regulation of growth)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045296"(cadherin binding)|go:"GO:0048538"(thymus development)|go:"GO:0051301"(cell division)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|mint:O95067|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-8852276|dip:DIP-31730N	ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:7ztz22HOOgNq/6KO1iXhGT3tb+A9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:eR5KD0JtxC+21uHo9Y/CB+FpApM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24941	uniprotkb:P46527	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087275|imex:IM-22343-15|dip:DIP-195853E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:CKWESbvGzUtu9/Z94zaEpsx5HM0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24941	uniprotkb:Q9UQR0-1	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-16087037|ensembl:ENSP00000251900	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087275|imex:IM-22343-15|dip:DIP-195853E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:CKWESbvGzUtu9/Z94zaEpsx5HM0	false	-	sufficient binding region:1-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UQR0-1	uniprotkb:O96020	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087295|imex:IM-22343-16|dip:DIP-195856E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rigid:KVWOyu2n/vxJg2L5dLJhnS0Zr+s	false	sufficient binding region:1-609|one-strep-tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UQR0-1	uniprotkb:P24941	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087295|imex:IM-22343-16|dip:DIP-195856E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:KVWOyu2n/vxJg2L5dLJhnS0Zr+s	false	sufficient binding region:1-609|one-strep-tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24941	uniprotkb:P46527	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087318|imex:IM-22343-17|dip:DIP-195853E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:CKWESbvGzUtu9/Z94zaEpsx5HM0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24941	uniprotkb:Q9UQR0-1	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-16087037|ensembl:ENSP00000251900	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087318|imex:IM-22343-17|dip:DIP-195853E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:CKWESbvGzUtu9/Z94zaEpsx5HM0	false	-	sufficient binding region:1-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24941	uniprotkb:Q9UQR0	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087338|imex:IM-22343-18|dip:DIP-195850E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:R+JQN7YvcxWGLVpFeKR8cjPmsLs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46527	uniprotkb:Q9UQR0-1	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	intact:EBI-16087037|ensembl:ENSP00000251900	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087355|imex:IM-22343-19|dip:DIP-195854E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:kzRLqjAtisf2TwyfPuNFPdhgPlk	false	-	sufficient binding region:1-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O96020	uniprotkb:P24941	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087395|imex:IM-22343-21|dip:DIP-195857E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:3+Dly3t4JsUTGdxwOTi38x8Kvn0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96020	uniprotkb:P38936	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087395|imex:IM-22343-21|dip:DIP-195857E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:3+Dly3t4JsUTGdxwOTi38x8Kvn0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96020	uniprotkb:P46527	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087395|imex:IM-22343-21|dip:DIP-195857E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:3+Dly3t4JsUTGdxwOTi38x8Kvn0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O96020	uniprotkb:Q9UQR0	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087395|imex:IM-22343-21|dip:DIP-195857E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:3+Dly3t4JsUTGdxwOTi38x8Kvn0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9UQR0-1	uniprotkb:P38936	intact:EBI-16087037|ensembl:ENSP00000251900	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087374|imex:IM-22343-20|dip:DIP-195851E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:Dtrsqk4xjNhABCZhv1qB230Pvdo	false	sufficient binding region:491-700	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06493	uniprotkb:P46527	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	intact:EBI-519280|uniprotkb:Q16307|uniprotkb:Q9BUS6|ensembl:ENSP00000228872|ensembl:ENSP00000507272|uniprotkb:Q5U0H2	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:cdn1b_human(display_long)|uniprotkb:Cyclin-dependent kinase inhibitor p27(gene name synonym)|uniprotkb:p27Kip1(gene name synonym)|uniprotkb:CDKN1B(gene name)|psi-mi:CDKN1B(display_short)|uniprotkb:KIP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087415|imex:IM-22343-22|dip:DIP-195855E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	refseq:NP_004055.1|rcsb pdb:1JSU|rcsb pdb:2AST|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6P8E|rcsb pdb:6P8F|rcsb pdb:6P8G|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5625900|reactome:R-HSA-5674400|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-9607240|reactome:R-HSA-9617828|reactome:R-HSA-9634638|reactome:R-HSA-9661069|ensembl:ENSG00000111276(gene)|ensembl:ENST00000228872(transcript)|ensembl:ENST00000614874(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001890"(placenta development)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048102"(autophagic cell death)|go:"GO:0048839"(inner ear development)|go:"GO:0051087"(chaperone binding)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090398"(cellular senescence)|go:"GO:1902746"(regulation of lens fiber cell differentiation)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029843|mint:P46527|rcsb pdb:1H27|dip:DIP-33341N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	rogid:UGcAvE0fJ9JmjMbh0s4ILpSzV+49606	rigid:CGO4nN6IM8WXtwHpdkNE0v/fO/c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06493	uniprotkb:Q9UQR0-1	intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4	intact:EBI-16087037|ensembl:ENSP00000251900	psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym)	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087415|imex:IM-22343-22|dip:DIP-195855E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:CGO4nN6IM8WXtwHpdkNE0v/fO/c	false	-	sufficient binding region:1-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O96020	uniprotkb:P38936	intact:EBI-375033|uniprotkb:O95439|ensembl:ENSP00000309181|ensembl:ENSP00000429089	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:ccne2_human(display_long)|uniprotkb:CCNE2(gene name)|psi-mi:CCNE2(display_short)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087453|imex:IM-22343-24|dip:DIP-61214E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477097.1|ensembl:ENST00000308108(transcript)|ensembl:ENST00000520509(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|reactome:R-HSA-1538133|reactome:R-HSA-187577|reactome:R-HSA-2559586|reactome:R-HSA-390471|reactome:R-HSA-6804116|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-9661069|ensembl:ENSG00000175305(gene)|refseq:XP_016869446.1|refseq:XP_016869447.1|refseq:XP_016869448.1|dip:DIP-31733N	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:urbnnQYqigb2gS6jMHWruQpct+s9606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:4pwjmIx9zTCoyXfi2lqDud1pdik	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24941	uniprotkb:P38936	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087435|imex:IM-22343-23|dip:DIP-195852E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rigid:NtoA9neUsTUme8z6nWMk4fxVpLI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P24941	uniprotkb:Q9UQR0	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087435|imex:IM-22343-23|dip:DIP-195852E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:NtoA9neUsTUme8z6nWMk4fxVpLI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P38936	uniprotkb:P24941	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087470|imex:IM-22343-25|dip:DIP-195852E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	rigid:NtoA9neUsTUme8z6nWMk4fxVpLI	false	glutathione s tranferase tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P38936	uniprotkb:Q9UQR0-1	intact:EBI-375077|uniprotkb:Q14010|uniprotkb:Q9BUT4|uniprotkb:Q6FI05|ensembl:ENSP00000244741|ensembl:ENSP00000362815|ensembl:ENSP00000384849|ensembl:ENSP00000409259|ensembl:ENSP00000482768	intact:EBI-16087037|ensembl:ENSP00000251900	psi-mi:cdn1a_human(display_long)|uniprotkb:CDKN1A(gene name)|psi-mi:CDKN1A(display_short)|uniprotkb:CAP20(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:CIP1(gene name synonym)|uniprotkb:MDA6(gene name synonym)|uniprotkb:PIC1(gene name synonym)|uniprotkb:SDI1(gene name synonym)|uniprotkb:WAF1(gene name synonym)|uniprotkb:p21(gene name synonym)|uniprotkb:CDK-interacting protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 6(gene name synonym)	psi-mi:q9uqr0-1(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short)	psi-mi:"MI:0096"(pull down)	Lecona et al. (2013)	pubmed:24358021|doi:10.1371/journal.pbio.1001737|imex:IM-22343	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16087470|imex:IM-22343-25|dip:DIP-195852E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278478.1|ensembl:ENSG00000124762(gene)|ensembl:ENST00000244741(transcript)|ensembl:ENST00000373711(transcript)|ensembl:ENST00000405375(transcript)|ensembl:ENST00000448526(transcript)|ensembl:ENST00000615513(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010165"(response to X-ray)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|refseq:NP_000380.1|refseq:NP_001207706.1|refseq:NP_001207707.1|refseq:NP_510867.1|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090398"(cellular senescence)|go:"GO:0090399"(replicative senescence)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905179"(negative regulation of cardiac muscle tissue regeneration)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR003175(Cyclin-dependent kinase inhibitor)|interpro:IPR029841|mint:P38936|rcsb pdb:1AXC|rcsb pdb:2ZVV|rcsb pdb:2ZVW|rcsb pdb:4RJF|rcsb pdb:5E0U|rcsb pdb:6CBI|rcsb pdb:6CEJ|rcsb pdb:6CIV|rcsb pdb:6CIX|rcsb pdb:6P8H|reactome:R-HSA-187577|reactome:R-HSA-198323|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5674400|reactome:R-HSA-6785807|reactome:R-HSA-6804116|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8866911|reactome:R-HSA-8878166|reactome:R-HSA-8941855|reactome:R-HSA-9616222|reactome:R-HSA-9617828|reactome:R-HSA-9661069|reactome:R-HSA-9702518|reactome:R-HSA-9703465|dip:DIP-246N	intact:EBI-2513111(isoform-parent)|ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:9GjjylWSA7IM/g1ZUxNAKyFtCp49606	rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606	rigid:NtoA9neUsTUme8z6nWMk4fxVpLI	false	glutathione s tranferase tag:n-n	sufficient binding region:1-609	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)