#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O88273	uniprotkb:O88273	intact:EBI-16064759|ensembl:ENSMUSP00000049640	intact:EBI-16064759|ensembl:ENSMUSP00000049640	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Nolan et al. (2013)	pubmed:23850456|doi:10.1016/j.str.2013.06.005|imex:IM-21557	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16064793|imex:IM-21557-1|dip:DIP-191950E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rigid:JMm4maKEC+ks/2wgs+Ms+jxPDH0	false	sufficient binding region:22-168	sufficient binding region:22-168	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12643	uniprotkb:O88273	intact:EBI-1029262|ensembl:ENSP00000368104	intact:EBI-16064759|ensembl:ENSMUSP00000049640	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nolan et al. (2013)	pubmed:23850456|doi:10.1016/j.str.2013.06.005|imex:IM-21557	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16064811|imex:IM-21557-2|dip:DIP-191951E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rigid:0Zt3ql/xJAhEl3cHXLmM9jU+Jc8	false	sufficient binding region:283-396	sufficient binding region:22-168|mutation decreasing interaction strength:98-98|mutation decreasing interaction strength:104-104|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:72-72|mutation decreasing interaction strength:117-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88273	uniprotkb:O88273	intact:EBI-16064759|ensembl:ENSMUSP00000049640	intact:EBI-16064759|ensembl:ENSMUSP00000049640	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:"MI:0826"(x ray scattering)	Nolan et al. (2013)	pubmed:23850456|doi:10.1016/j.str.2013.06.005|imex:IM-21557	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16064847|imex:IM-21557-3|dip:DIP-191950E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rigid:JMm4maKEC+ks/2wgs+Ms+jxPDH0	false	sufficient binding region:22-168	sufficient binding region:22-168	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O88273	uniprotkb:O88273	intact:EBI-16064759|ensembl:ENSMUSP00000049640	intact:EBI-16064759|ensembl:ENSMUSP00000049640	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Nolan et al. (2013)	pubmed:23850456|doi:10.1016/j.str.2013.06.005|imex:IM-21557	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16064866|imex:IM-21557-4|dip:DIP-191950E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rigid:JMm4maKEC+ks/2wgs+Ms+jxPDH0	false	sufficient binding region:22-168	sufficient binding region:22-168	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P12644	uniprotkb:O88273	intact:EBI-1998134|uniprotkb:Q9UM80|ensembl:ENSP00000245451|ensembl:ENSP00000394165|ensembl:ENSP00000453485|ensembl:ENSP00000454134	intact:EBI-16064759|ensembl:ENSMUSP00000049640	psi-mi:bmp4_human(display_long)|uniprotkb:BMP4(gene name)|psi-mi:BMP4(display_short)|uniprotkb:BMP2B(gene name synonym)|uniprotkb:DVR4(gene name synonym)|uniprotkb:Bone morphogenetic protein 2B(gene name synonym)	psi-mi:grem2_mouse(display_long)|uniprotkb:Grem2(gene name)|psi-mi:Grem2(display_short)|uniprotkb:Cktsf1b2(gene name synonym)|uniprotkb:Prdc(gene name synonym)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 2(gene name synonym)|uniprotkb:Protein related to DAN and cerberus(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Nolan et al. (2013)	pubmed:23850456|doi:10.1016/j.str.2013.06.005|imex:IM-21557	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16064884|imex:IM-21557-5|dip:DIP-191952E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_570911.2|refseq:NP_001193.2|refseq:NP_001334843.1|refseq:NP_001334845.1|refseq:NP_570912.2|dip:DIP-5795N|go:"GO:0072200"(negative regulation of mesenchymal cell proliferation involved in ureter development)|go:"GO:0072205"(metanephric collecting duct development)|go:"GO:0090184"(positive regulation of kidney development)|go:"GO:0090191"(negative regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090194"(negative regulation of glomerulus development)|go:"GO:1901964"(positive regulation of cell proliferation involved in outflow tract morphogenesis)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905312"(positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:2000005"(negative regulation of metanephric S-shaped body morphogenesis)|go:"GO:2000007"(negative regulation of metanephric comma-shaped body morphogenesis)|go:"GO:2000137"(negative regulation of cell proliferation involved in heart morphogenesis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275|ensembl:ENSG00000125378(gene)|ensembl:ENST00000245451(transcript)|ensembl:ENST00000417573(transcript)|ensembl:ENST00000558984(transcript)|ensembl:ENST00000559087(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001822"(kidney development)|go:"GO:0001823"(mesonephros development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0003014"(renal system process)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003149"(membranous septum morphogenesis)|go:"GO:0003163"(sinoatrial node development)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007281"(germ cell development)|go:"GO:0007492"(endoderm development)|go:"GO:0007500"(mesodermal cell fate determination)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010159"(specification of animal organ position)|go:"GO:0010453"(regulation of cell fate commitment)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0021537"(telencephalon development)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033085"(negative regulation of T cell differentiation in thymus)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035990"(tendon cell differentiation)|go:"GO:0035993"(deltoid tuberosity development)|go:"GO:0039706"(co-receptor binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042476"(odontogenesis)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043401"(steroid hormone mediated signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048392"(intermediate mesodermal cell differentiation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051150"(regulation of smooth muscle cell differentiation)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055020"(positive regulation of cardiac muscle fiber development)|go:"GO:0060113"(inner ear receptor cell differentiation)|go:"GO:0060197"(cloacal septation)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060272"(embryonic skeletal joint morphogenesis)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060433"(bronchus development)|go:"GO:0060438"(trachea development)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060503"(bud dilation involved in lung branching)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060592"(mammary gland formation)|go:"GO:0060684"(epithelial-mesenchymal cell signaling)|go:"GO:0060686"(negative regulation of prostatic bud formation)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061149"(BMP signaling pathway involved in ureter morphogenesis)|go:"GO:0061151"(BMP signaling pathway involved in renal system segmentation)|go:"GO:0061155"(pulmonary artery endothelial tube morphogenesis)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0071893"(BMP signaling pathway involved in nephric duct formation)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072097"(negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway)|go:"GO:0072101"(specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072125"(negative regulation of glomerular mesangial cell proliferation)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0072161"(mesenchymal cell differentiation involved in kidney development)|go:"GO:0072192"(ureter epithelial cell differentiation)|go:"GO:0072193"(ureter smooth muscle cell differentiation)|go:"GO:0072198"(mesenchymal cell proliferation involved in ureter development)	ensembl:ENSMUSG00000050069(gene)|ensembl:ENSMUST00000055294(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008201"(heparin binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010172"(embryonic body morphogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060300"(regulation of cytokine activity)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:4JPH|rcsb pdb:5HK5|reactome:R-MMU-201451|refseq:NP_035955.1|refseq:XP_006496889.1|refseq:XP_017175937.1|dip:DIP-60475N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:HQjZUJQMMkLov0JIQOQVh7NN7zM9606	rogid:32ZIrazh6vhcEmdU/bKH0Ta9bHY10090	rigid:gUV5g8qMEM1ImaRGplpiy1wqhZ8	false	sufficient binding region:293-408	sufficient binding region:22-168|mutation decreasing interaction strength:98-98|mutation decreasing interaction strength:104-104|mutation decreasing interaction strength:105-105|mutation decreasing interaction strength:72-72|mutation decreasing interaction strength:117-117	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)