#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01116-2	uniprotkb:O43924	intact:EBI-367427|uniprotkb:P01118-1|ensembl:ENSP00000308495	intact:EBI-712685|uniprotkb:O43250|ensembl:ENSP00000287600	psi-mi:p01116-2(display_long)|uniprotkb:KRAS(gene name)|psi-mi:KRAS(display_short)|uniprotkb:KRAS2(gene name synonym)|uniprotkb:RASK2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)|uniprotkb:K-Ras4B(isoform synonym)	psi-mi:pde6d_human(display_long)|uniprotkb:Protein p17(gene name synonym)|uniprotkb:PDE6D(gene name)|psi-mi:PDE6D(display_short)|uniprotkb:PDED(gene name synonym)	psi-mi:"MI:0905"(amplified luminescent proximity homogeneous assay)	Zimmermann et al. (2013)	pubmed:23698361|doi:10.1038/nature12205|imex:IM-21103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-16058388|imex:IM-21103-1|dip:DIP-190956E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-367415(rask_human)|ensembl:ENSG00000133703(gene)|ensembl:ENST00000311936(transcript)|uniprotkb:P01116-2(isoform-parent)	refseq:NP_001277947.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050896"(response to stimulus)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017287(Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit)|interpro:IPR037036|mint:O43924|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:3T5G|rcsb pdb:3T5I|rcsb pdb:4JHP|rcsb pdb:4JV6|rcsb pdb:4JV8|rcsb pdb:4JVB|rcsb pdb:4JVF|rcsb pdb:5E80|rcsb pdb:5E8F|rcsb pdb:5F2U|rcsb pdb:5ML2|rcsb pdb:5ML3|rcsb pdb:5ML4|rcsb pdb:5ML6|rcsb pdb:5ML8|rcsb pdb:5NAL|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5X72|rcsb pdb:5X73|rcsb pdb:5X74|rcsb pdb:5YAV|rcsb pdb:5YAW|reactome:R-HSA-5624958|ensembl:ENSG00000156973(gene)|ensembl:ENST00000287600(transcript)|go:"GO:0005095"(GTPase inhibitor activity)|reactome:R-HSA-9648002|refseq:NP_002592.1|dip:DIP-36660N	psi-mi:"MI:0465"(dip)	isoform-comment:"Variant in position: 152:V->G (in NS3). Variant in position: 153:D->V (in CFC2 and NS3, exhibits only minor alterations in its in vitro biochemical behavior compared to wild-type protein). Variant in position: 156:F->I (in NS3/CFC2). Variant in position: 156:F->L (found in a patient with Costello syndrome, exhibits an increase in intrinsic and guanine nucleotide exchange factor catalyzed nucleotide exchange in combination with an impaired GTPase-activating protein-stimulated GTP hydrolysis but functional in interaction with effectors)."	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:vHSaLYCo0d2r24erApiG/TCTmBc9606	rogid:dfEOckvNZPhkWSeQnKr4ugEdEmM9606	rigid:1Hj+XVD20tWfsz7za66TORHmumI	false	sufficient binding region:175-185|biotin tag:?-?|farnesylated residue:185-185	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15382	uniprotkb:O43924	intact:EBI-1055287|uniprotkb:Q53Y56|uniprotkb:Q99444|uniprotkb:B3KWN6|uniprotkb:D3DX13|ensembl:ENSP00000262187	intact:EBI-712685|uniprotkb:O43250|ensembl:ENSP00000287600	psi-mi:rheb_human(display_long)|uniprotkb:Ras homolog enriched in brain(gene name synonym)|uniprotkb:RHEB(gene name)|psi-mi:RHEB(display_short)|uniprotkb:RHEB2(gene name synonym)	psi-mi:pde6d_human(display_long)|uniprotkb:Protein p17(gene name synonym)|uniprotkb:PDE6D(gene name)|psi-mi:PDE6D(display_short)|uniprotkb:PDED(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Zimmermann et al. (2013)	pubmed:23698361|doi:10.1038/nature12205|imex:IM-21103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0465"(DIP)	intact:EBI-16058415|imex:IM-21103-2|dip:DIP-190957E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005605.1|ensembl:ENSG00000106615(gene)|ensembl:ENST00000262187(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:2000074"(regulation of type B pancreatic cell development)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR037586|mint:Q15382|rcsb pdb:1XTQ|rcsb pdb:1XTR|rcsb pdb:1XTS|rcsb pdb:3SEA|rcsb pdb:3T5G|rcsb pdb:5YXH|rcsb pdb:6BCU|rcsb pdb:6BSX|rcsb pdb:6BT0|rcsb pdb:7BTA|rcsb pdb:7BTC|rcsb pdb:7BTD|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-8943724|reactome:R-HSA-9639288|go:"GO:0019003"(GDP binding)|dip:DIP-42816N	refseq:NP_001277947.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005929"(cilium)|go:"GO:0007601"(visual perception)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0050896"(response to stimulus)|interpro:IPR008015(GMP phosphodiesterase, delta subunit)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017287(Retinal rod rhodopsin-sensitive cGMP 3', 5'-cyclic phosphodiesterase, delta subunit)|interpro:IPR037036|mint:O43924|rcsb pdb:1KSG|rcsb pdb:1KSH|rcsb pdb:1KSJ|rcsb pdb:3T5G|rcsb pdb:3T5I|rcsb pdb:4JHP|rcsb pdb:4JV6|rcsb pdb:4JV8|rcsb pdb:4JVB|rcsb pdb:4JVF|rcsb pdb:5E80|rcsb pdb:5E8F|rcsb pdb:5F2U|rcsb pdb:5ML2|rcsb pdb:5ML3|rcsb pdb:5ML4|rcsb pdb:5ML6|rcsb pdb:5ML8|rcsb pdb:5NAL|rcsb pdb:5TAR|rcsb pdb:5TB5|rcsb pdb:5X72|rcsb pdb:5X73|rcsb pdb:5X74|rcsb pdb:5YAV|rcsb pdb:5YAW|reactome:R-HSA-5624958|ensembl:ENSG00000156973(gene)|ensembl:ENST00000287600(transcript)|go:"GO:0005095"(GTPase inhibitor activity)|reactome:R-HSA-9648002|refseq:NP_002592.1|dip:DIP-36660N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	-	2017/08/07	2017/08/10	rogid:GE8DyIWfwPVdBLbXAI3mHbo1uVs9606	rogid:dfEOckvNZPhkWSeQnKr4ugEdEmM9606	rigid:0ObQ1/j8+QzKY5J0yKKesxlkpKU	false	fluorescent protein tag:n-n	mcherry fluorescent protein tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)