#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C774 uniprotkb:Q9BYX4 intact:EBI-3650423 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_measc(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:645098(measc)|taxid:645098("measles virus (strai") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16032166|imex:IM-24823-2|dip:DIP-199812E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61740N|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:0aFagySVKBo/tRrrTXX177Fbqhc645098 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rigid:LJLh8op3an8N3OXDEofYYGpksH4 false - flag tag:n-n|mutation decreasing interaction strength:806-806 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A7LCX1 uniprotkb:P11207 intact:EBI-16032125 intact:EBI-6148694 psi-mi:a7lcx1_pig(display_long)|uniprotkb:MDA5(gene name)|psi-mi:MDA5(display_short) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0114"(x-ray crystallography) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032145|imex:IM-24823-1|dip:DIP-199806E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:4I1S|refseq:NP_001093664.1|dip:DIP-61736N mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:j6BrjRmo5u5DJS/9YppdH+ajHvE9823 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:pZ05jZ+Abo1qTac8F9nqWpU2W7Q false sufficient binding region:546-808 sufficient binding region:168-219 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R5F7-1 uniprotkb:P11207 intact:EBI-16019291|ensembl:ENSMUSP00000028259 intact:EBI-6148694 psi-mi:q8r5f7-1(display_long)|uniprotkb:Ifih1(gene name)|psi-mi:Ifih1(display_short)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032254|imex:IM-24823-5|dip:DIP-199808E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8391437(isoform-parent)|ensembl:ENSMUSG00000026896(gene)|ensembl:ENSMUST00000028259(transcript) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:GbJDSjeteps9V0LsRHeZ1HnfTFA10090 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:GyR1Mcq5GS2j8+IVZN8b4edQpBI false sufficient binding region:305-890 mutation decreasing interaction strength:174-174 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:A7LCX1 uniprotkb:P11207 intact:EBI-16032125 intact:EBI-6148694 psi-mi:a7lcx1_pig(display_long)|uniprotkb:MDA5(gene name)|psi-mi:MDA5(display_short) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032235|imex:IM-24823-4|dip:DIP-199806E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:4I1S|refseq:NP_001093664.1|dip:DIP-61736N mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:j6BrjRmo5u5DJS/9YppdH+ajHvE9823 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:pZ05jZ+Abo1qTac8F9nqWpU2W7Q false sufficient binding region:303-887 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:D9N195 uniprotkb:P11207 intact:EBI-16032188 intact:EBI-6148694 psi-mi:d9n195_chick(display_long)|uniprotkb:MDA5(gene name)|psi-mi:MDA5(display_short) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032216|imex:IM-24823-3|dip:DIP-199810E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:5JC3|rcsb pdb:5JC7|rcsb pdb:5JCF|rcsb pdb:5JCH|refseq:NP_001180567.1|reactome:R-GGA-1227739|reactome:R-GGA-1227882|reactome:R-GGA-1227887|reactome:R-GGA-1227888|reactome:R-GGA-1227892|dip:DIP-61737N mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:4A1z88LuTI1GDiu9AdMM+P9mr4M9031 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:woxH8Ud3iiZxyEUpay0GfcbU3WI false sufficient binding region:297-864 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:H0Z993 uniprotkb:P11207 intact:EBI-16032279|ensembl:ENSTGUP00000007146 intact:EBI-6148694 psi-mi:h0z993_taegu(display_long)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:59729(taegu)|taxid:59729(Taeniopygia guttata) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032311|imex:IM-24823-6|dip:DIP-199811E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSTGUG00000006914(gene)|ensembl:ENSTGUT00000007216(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|go:"GO:0042802"(identical protein binding)|dip:DIP-61739N mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2020/06/19 rogid:yjZ4iXe0dQILlvNNeGZxFFMXBUM59729 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:XutfUKzrwAp+7rWjiciThVWCux8 false sufficient binding region:362-919 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6Q899-1 uniprotkb:P11207 intact:EBI-16032330|ensembl:ENSMUSP00000042433 intact:EBI-6148694 psi-mi:q6q899-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:Ddx58(gene name)|psi-mi:Ddx58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032339|imex:IM-24823-7|dip:DIP-199814E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000040296(gene)|ensembl:ENSMUST00000037907(transcript)|intact:EBI-6841237(isoform-parent) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:CNjgbIrnNJvLHk3wwhQASTxTvGI10090 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:OpVQqXVxw6ZtNt5LvybKBsePBGE false mutation increasing interaction strength:717-717,715-715 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:E1BJZ0 uniprotkb:P11207 intact:EBI-16032442|ensembl:ENSBTAP00000010703 intact:EBI-6148694 psi-mi:e1bjz0_bovin(display_long)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032475|imex:IM-24823-12|dip:DIP-199809E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000008142(gene)|ensembl:ENSBTAT00000010703(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|reactome:R-BTA-5689880|refseq:XP_010800355.1|refseq:XP_010824766.1|dip:DIP-61738N mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:IOyzJXCIQwBmLfTfVZlvWeq+ghU9913 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:52ASX+Clsx4Ylj1RpAXjHm4cSiw false sufficient binding region:303-885 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R5F7-1 uniprotkb:P11207 intact:EBI-16019291|ensembl:ENSMUSP00000028259 intact:EBI-6148694 psi-mi:q8r5f7-1(display_long)|uniprotkb:Ifih1(gene name)|psi-mi:Ifih1(display_short)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0826"(x ray scattering) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032423|imex:IM-24823-11|dip:DIP-199808E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8391437(isoform-parent)|ensembl:ENSMUSG00000026896(gene)|ensembl:ENSMUST00000028259(transcript) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:GbJDSjeteps9V0LsRHeZ1HnfTFA10090 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:GyR1Mcq5GS2j8+IVZN8b4edQpBI false sufficient binding region:305-890 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C774 uniprotkb:Q9BYX4 intact:EBI-3650423 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 psi-mi:v_measc(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:645098(measc)|taxid:645098("measles virus (strai") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16032401|imex:IM-24823-10|dip:DIP-199812E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61740N|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:0aFagySVKBo/tRrrTXX177Fbqhc645098 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rigid:LJLh8op3an8N3OXDEofYYGpksH4 false mutation decreasing interaction strength:235-235 flag tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8R5F7-1 uniprotkb:P11207 intact:EBI-16019291|ensembl:ENSMUSP00000028259 intact:EBI-6148694 psi-mi:q8r5f7-1(display_long)|uniprotkb:Ifih1(gene name)|psi-mi:Ifih1(display_short)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032379|imex:IM-24823-9|dip:DIP-199808E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-8391437(isoform-parent)|ensembl:ENSMUSG00000026896(gene)|ensembl:ENSMUST00000028259(transcript) mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:GbJDSjeteps9V0LsRHeZ1HnfTFA10090 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:GyR1Mcq5GS2j8+IVZN8b4edQpBI false sufficient binding region:305-890|mutation disrupting interaction strength:806-806 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9BYX4 uniprotkb:P11207 intact:EBI-6115771|uniprotkb:Q2NKL6|uniprotkb:Q6DC96|uniprotkb:Q86X56|uniprotkb:Q96MX8|uniprotkb:Q9H3G6|ensembl:ENSP00000497271 intact:EBI-6148694 psi-mi:ifih1_human(display_long)|uniprotkb:Helicase with 2 CARD domains(gene name synonym)|uniprotkb:Interferon-induced with helicase C domain protein 1(gene name synonym)|uniprotkb:Melanoma differentiation-associated protein 5(gene name synonym)|uniprotkb:Murabutide down-regulated protein(gene name synonym)|uniprotkb:RNA helicase-DEAD box protein 116(gene name synonym)|uniprotkb:RIG-I-like receptor 2(gene name synonym)|uniprotkb:IFIH1(gene name)|psi-mi:IFIH1(display_short)|uniprotkb:MDA5(gene name synonym)|uniprotkb:RH116(gene name synonym)|uniprotkb:Clinically amyopathic dermatomyositis autoantigen 140 kDa(gene name synonym) psi-mi:v_piv5(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:"MI:0071"(molecular sieving) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:11208(sv5)|taxid:11208("Simian virus 5 (strain W3)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16032360|imex:IM-24823-8|dip:DIP-199807E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_071451.2|dip:DIP-42607N|ensembl:ENSG00000115267(gene)|ensembl:ENST00000649979(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009597"(detection of virus)|go:"GO:0009615"(response to virus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034344"(regulation of type III interferon production)|go:"GO:0039528"(cytoplasmic pattern recognition receptor signaling pathway in response to virus)|go:"GO:0039530"(MDA-5 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0098586"(cellular response to virus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011029(DEATH-like)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR021673|interpro:IPR027417|interpro:IPR031964|interpro:IPR038557|interpro:IPR041204|rcsb pdb:2RQB|rcsb pdb:3B6E|rcsb pdb:3GA3|rcsb pdb:4GL2|rcsb pdb:7JL0|rcsb pdb:7JL2|reactome:R-HSA-168928|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440 mint:P11207|dip:DIP-48759N|go:"GO:0003723"(RNA binding)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR025909|rcsb pdb:2HYE|rcsb pdb:2K48|rcsb pdb:4I1S|rcsb pdb:2B5L psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:d+r0DiHIxi32jKF7uOTENK3r/qQ9606 rogid:cmlnevM0HJgKJibzPH+KhOrSiKc11208 rigid:plT166ORYovX+dMGu5ZJJa8sotw false sufficient binding region:304-890 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C774 uniprotkb:O95786-1 intact:EBI-3650423 intact:EBI-15577823|ensembl:ENSP00000369213 psi-mi:v_measc(display_long)|uniprotkb:P/V(gene name)|psi-mi:P/V(display_short) psi-mi:o95786-1(display_long)|uniprotkb:Probable ATP-dependent RNA helicase DDX58(gene name synonym)|uniprotkb:DDX58(gene name)|psi-mi:DDX58(display_short)|uniprotkb:DEAD box protein 58(gene name synonym)|uniprotkb:RIG-I-like receptor 1(gene name synonym)|uniprotkb:Retinoic acid-inducible gene 1 protein(gene name synonym)|uniprotkb:Retinoic acid-inducible gene I protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Motz et al. (2013) pubmed:23328395|doi:10.1126/science.1230949|imex:IM-24823 taxid:645098(measc)|taxid:645098("measles virus (strai") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16032494|imex:IM-24823-13|dip:DIP-199813E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-61740N|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039557"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR024279|interpro:IPR028243 ensembl:ENSG00000107201(gene)|ensembl:ENST00000379883(transcript)|intact:EBI-995350(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:0aFagySVKBo/tRrrTXX177Fbqhc645098 rogid:nAw8D8xPo46hNj9gg2hjFeA5Mtc9606 rigid:QvbWTnYprqYWL4leskOBwGDAXLU false - flag tag:n-n|mutation increasing interaction strength:714-714|mutation increasing interaction strength:716-716,714-714 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)