#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P02730	uniprotkb:P16452	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1182496|uniprotkb:Q4VB97|uniprotkb:Q4KKX0|ensembl:ENSP00000396616	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:epb42_human(display_long)|uniprotkb:EPB42(gene name)|psi-mi:EPB42(display_short)|uniprotkb:E42P(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_000110.2|refseq:NP_001107606.1|refseq:XP_011519653.1|refseq:XP_011519651.1|refseq:XP_011519652.1|ensembl:ENSG00000166947(gene)|ensembl:ENST00000441366(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0048536"(spleen development)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:3HojdnCHcXhXVejly3k9UPytmh89606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:O75955	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q14254	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P23276	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-746662|uniprotkb:Q96RS8|uniprotkb:Q99885|uniprotkb:B2RBV4|ensembl:ENSP00000347409|ensembl:ENSP00000477793	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:kell_human(display_long)|uniprotkb:KEL(gene name)|psi-mi:KEL(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_000411.1|ensembl:ENSG00000197993(gene)|ensembl:ENSG00000276615(gene)|ensembl:ENST00000355265(transcript)|ensembl:ENST00000615381(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010961"(cellular magnesium ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0031133"(regulation of axon diameter)|go:"GO:0042310"(vasoconstriction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029737|interpro:IPR042089|reactome:R-HSA-375276|go:"GO:0042552"(myelination)	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:GjqydvNcosNtniZGvNOGt3XuS6Y9606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q9NP59	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-725153|uniprotkb:Q7Z4F8|uniprotkb:Q8IVB2|uniprotkb:Q9NRL0|uniprotkb:Q6FI62|ensembl:ENSP00000261024	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:s40a1_human(display_long)|uniprotkb:Ferroportin-1(gene name synonym)|uniprotkb:Iron-regulated transporter 1(gene name synonym)|uniprotkb:SLC40A1(gene name)|psi-mi:SLC40A1(display_short)|uniprotkb:FPN1(gene name synonym)|uniprotkb:IREG1(gene name synonym)|uniprotkb:SLC11A3(gene name synonym)|uniprotkb:MSTP079(orf name)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_055400.1|ensembl:ENSG00000138449(gene)|ensembl:ENST00000261024(transcript)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1903988"(iron ion export across plasma membrane)|interpro:IPR009716(Ferroportin1)|interpro:IPR036259|mint:Q9NP59|rcsb pdb:6W4S|rcsb pdb:6WBV|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-5655799|reactome:R-HSA-917937	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:0SUoNbS3VZY+7J/6QMI96UaPOiI9606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q13336	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-16356018|ensembl:ENSP00000318546|ensembl:ENSP00000465702|ensembl:ENSP00000470476|uniprotkb:A8K0P3|uniprotkb:B3KR62|uniprotkb:B3KVX3|uniprotkb:C9EHF2|uniprotkb:Q86VM5	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:ut1_human(display_long)|uniprotkb:SLC14A1(gene name)|psi-mi:SLC14A1(display_short)|uniprotkb:HUT11(gene name synonym)|uniprotkb:JK(gene name synonym)|uniprotkb:RACH1(gene name synonym)|uniprotkb:Solute carrier family 14 member 1(gene name synonym)|uniprotkb:UT1(gene name synonym)|uniprotkb:UTE(gene name synonym)|uniprotkb:Urea transporter, erythrocyte(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426165|imex:IM-26158-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000141469(gene)|ensembl:ENST00000321925(transcript)|ensembl:ENST00000586142(transcript)|ensembl:ENST00000586951(transcript)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015265"(urea channel activity)|go:"GO:0015840"(urea transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071918"(urea transmembrane transport)|interpro:IPR004937(Urea transporter)|interpro:IPR029020|rcsb pdb:6QD5|reactome:R-HSA-425366|dip:DIP-60049N|refseq:NP_001122060.3|refseq:NP_001139508.2|refseq:NP_001139509.1|refseq:NP_056949.4	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1ii|comment:Proteins found in the 500 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:DyDCqQdQ14nSdOOovEoEI0ODoq09606	rigid:JufpzyDyhlncKEwK+U26bFT/rh8	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:O75955	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426304|imex:IM-26158-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1i|comment:Proteins found in the 300 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:QPzXqx2oQGpL4kokCY7QIWiOH/A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426304|imex:IM-26158-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1i|comment:Proteins found in the 300 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:QPzXqx2oQGpL4kokCY7QIWiOH/A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426304|imex:IM-26158-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1i|comment:Proteins found in the 300 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:QPzXqx2oQGpL4kokCY7QIWiOH/A	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426297|imex:IM-26158-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1|comment:Proteins found in the 130 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:WB6XCZZtARQzLCFp8ymR6YvGOF0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426297|imex:IM-26158-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 1, supp fig 1|comment:Proteins found in the 130 kDa band.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:WB6XCZZtARQzLCFp8ymR6YvGOF0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426271|imex:IM-26158-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:1Ca|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:KbFORtsvxxPWqtGOuxS1a3mwRKw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426275|imex:IM-26158-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:1Cb|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:KbFORtsvxxPWqtGOuxS1a3mwRKw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04075	uniprotkb:P02730	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426344|imex:IM-26158-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Figure 2, supp fig 2|comment:proteins found in  300 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:HvpXYf766hK5ykjZ1mEW8oUT0Yk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:O75955	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426344|imex:IM-26158-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:Figure 2, supp fig 2|comment:proteins found in  300 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:HvpXYf766hK5ykjZ1mEW8oUT0Yk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:Q14254	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426344|imex:IM-26158-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	-	-	figure legend:Figure 2, supp fig 2|comment:proteins found in  300 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:HvpXYf766hK5ykjZ1mEW8oUT0Yk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P11166	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426344|imex:IM-26158-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:Figure 2, supp fig 2|comment:proteins found in  300 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:HvpXYf766hK5ykjZ1mEW8oUT0Yk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P27105	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426344|imex:IM-26158-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:Figure 2, supp fig 2|comment:proteins found in  300 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:HvpXYf766hK5ykjZ1mEW8oUT0Yk	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P50895	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-10212133|uniprotkb:A8MYF9|uniprotkb:Q86VC7|uniprotkb:A9YWT6|uniprotkb:A9YWT5|ensembl:ENSP00000270233	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:bcam_human(display_long)|uniprotkb:BCAM(gene name)|psi-mi:BCAM(display_short)|uniprotkb:Auberger B antigen(gene name synonym)|uniprotkb:B-CAM cell surface glycoprotein(gene name synonym)|uniprotkb:F8/G253 antigen(gene name synonym)|uniprotkb:LU(gene name synonym)|uniprotkb:Lutheran antigen(gene name synonym)|uniprotkb:Lutheran blood group glycoprotein(gene name synonym)|uniprotkb:MSK19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_001013275.1|refseq:NP_005572.2|ensembl:ENSG00000187244(gene)|ensembl:ENST00000270233(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0043236"(laminin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2PET|rcsb pdb:2PF6	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:x0+dyVBq4nocOVEnSdGdWpXqpx89606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:O75955	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q14254	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q14773	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1222232|uniprotkb:Q14771|uniprotkb:Q14772|uniprotkb:Q16375|uniprotkb:A0M8X2|uniprotkb:Q9BWR0|ensembl:ENSP00000370147	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:icam4_human(display_long)|uniprotkb:ICAM4(gene name)|psi-mi:ICAM4(display_short)|uniprotkb:LW(gene name synonym)|uniprotkb:Landsteiner-Wiener blood group glycoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_001535.1|refseq:NP_001034221.1|ensembl:ENSG00000105371(gene)|ensembl:ENST00000380770(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-216083	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:JDyu0Pl9b58ZxL07c+7AAmemhWs9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q9NP59	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-725153|uniprotkb:Q7Z4F8|uniprotkb:Q8IVB2|uniprotkb:Q9NRL0|uniprotkb:Q6FI62|ensembl:ENSP00000261024	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:s40a1_human(display_long)|uniprotkb:Ferroportin-1(gene name synonym)|uniprotkb:Iron-regulated transporter 1(gene name synonym)|uniprotkb:SLC40A1(gene name)|psi-mi:SLC40A1(display_short)|uniprotkb:FPN1(gene name synonym)|uniprotkb:IREG1(gene name synonym)|uniprotkb:SLC11A3(gene name synonym)|uniprotkb:MSTP079(orf name)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_055400.1|ensembl:ENSG00000138449(gene)|ensembl:ENST00000261024(transcript)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1903988"(iron ion export across plasma membrane)|interpro:IPR009716(Ferroportin1)|interpro:IPR036259|mint:Q9NP59|rcsb pdb:6W4S|rcsb pdb:6WBV|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-5655799|reactome:R-HSA-917937	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:0SUoNbS3VZY+7J/6QMI96UaPOiI9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P02549	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-375617|uniprotkb:Q15514|uniprotkb:Q6LDY5|ensembl:ENSP00000495214|uniprotkb:Q5VYL1|uniprotkb:Q5VYL2	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:spta1_human(display_long)|uniprotkb:SPTA1(gene name)|psi-mi:SPTA1(display_short)|uniprotkb:Erythroid alpha-spectrin(gene name synonym)|uniprotkb:SPTA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|ensembl:ENSG00000163554(gene)|ensembl:ENST00000643759(transcript)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008091"(spectrin)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030424"(axon)|interpro:IPR018159|interpro:IPR036028|mint:P02549|rcsb pdb:1OWA|rcsb pdb:3LBX|rcsb pdb:5J4O|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|interpro:IPR014837(EF-hand, Ca insensitive)|refseq:NP_003117.2|refseq:XP_011508218.1|dip:DIP-17031N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:ypX1j52WRHo4kBjtDJWfSAF99949606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11277	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-514908|uniprotkb:Q15510|uniprotkb:Q15519|ensembl:ENSP00000374370	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:sptb1_human(display_long)|uniprotkb:Beta-I spectrin(gene name synonym)|uniprotkb:SPTB(gene name)|psi-mi:SPTB(display_short)|uniprotkb:SPTB1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_000338.3|refseq:NP_001020029.1|refseq:XP_005268080.1|refseq:XP_016877101.1|refseq:XP_016877103.1|dip:DIP-1021N|ensembl:ENSG00000070182(gene)|ensembl:ENST00000389720(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0009986"(cell surface)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|rcsb pdb:1S35|rcsb pdb:3EDU|rcsb pdb:3F57|rcsb pdb:3KBT|rcsb pdb:3KBU|rcsb pdb:3LBX|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:pMUYFaSR/cKouM4GMi36sGK6aOU9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q13336	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-16356018|ensembl:ENSP00000318546|ensembl:ENSP00000465702|ensembl:ENSP00000470476|uniprotkb:A8K0P3|uniprotkb:B3KR62|uniprotkb:B3KVX3|uniprotkb:C9EHF2|uniprotkb:Q86VM5	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:ut1_human(display_long)|uniprotkb:SLC14A1(gene name)|psi-mi:SLC14A1(display_short)|uniprotkb:HUT11(gene name synonym)|uniprotkb:JK(gene name synonym)|uniprotkb:RACH1(gene name synonym)|uniprotkb:Solute carrier family 14 member 1(gene name synonym)|uniprotkb:UT1(gene name synonym)|uniprotkb:UTE(gene name synonym)|uniprotkb:Urea transporter, erythrocyte(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426320|imex:IM-26158-29	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	ensembl:ENSG00000141469(gene)|ensembl:ENST00000321925(transcript)|ensembl:ENST00000586142(transcript)|ensembl:ENST00000586951(transcript)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015265"(urea channel activity)|go:"GO:0015840"(urea transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071918"(urea transmembrane transport)|interpro:IPR004937(Urea transporter)|interpro:IPR029020|rcsb pdb:6QD5|reactome:R-HSA-425366|dip:DIP-60049N|refseq:NP_001122060.3|refseq:NP_001139508.2|refseq:NP_001139509.1|refseq:NP_056949.4	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2|comment:proteins found in  500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:DyDCqQdQ14nSdOOovEoEI0ODoq09606	rigid:WJxpcIb3W9YIGvMu9MCV4cMIO/k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:O75955	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426379|imex:IM-26158-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2i|comment:proteins found in  >500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:Qi21map1X/sbtiubKv4QoFpYJFs	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q14254	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426379|imex:IM-26158-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2i|comment:proteins found in  >500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:Qi21map1X/sbtiubKv4QoFpYJFs	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426379|imex:IM-26158-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2i|comment:proteins found in  >500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:Qi21map1X/sbtiubKv4QoFpYJFs	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q9NP59	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-725153|uniprotkb:Q7Z4F8|uniprotkb:Q8IVB2|uniprotkb:Q9NRL0|uniprotkb:Q6FI62|ensembl:ENSP00000261024	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:s40a1_human(display_long)|uniprotkb:Ferroportin-1(gene name synonym)|uniprotkb:Iron-regulated transporter 1(gene name synonym)|uniprotkb:SLC40A1(gene name)|psi-mi:SLC40A1(display_short)|uniprotkb:FPN1(gene name synonym)|uniprotkb:IREG1(gene name synonym)|uniprotkb:SLC11A3(gene name synonym)|uniprotkb:MSTP079(orf name)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426379|imex:IM-26158-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_055400.1|ensembl:ENSG00000138449(gene)|ensembl:ENST00000261024(transcript)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1903988"(iron ion export across plasma membrane)|interpro:IPR009716(Ferroportin1)|interpro:IPR036259|mint:Q9NP59|rcsb pdb:6W4S|rcsb pdb:6WBV|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-5655799|reactome:R-HSA-917937	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2i|comment:proteins found in  >500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:0SUoNbS3VZY+7J/6QMI96UaPOiI9606	rigid:Qi21map1X/sbtiubKv4QoFpYJFs	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P02549	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-375617|uniprotkb:Q15514|uniprotkb:Q6LDY5|ensembl:ENSP00000495214|uniprotkb:Q5VYL1|uniprotkb:Q5VYL2	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:spta1_human(display_long)|uniprotkb:SPTA1(gene name)|psi-mi:SPTA1(display_short)|uniprotkb:Erythroid alpha-spectrin(gene name synonym)|uniprotkb:SPTA(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426379|imex:IM-26158-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0031235"(intrinsic component of the cytoplasmic side of the plasma membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032437"(cuticular plate)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0051015"(actin filament binding)|go:"GO:0051693"(actin filament capping)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|ensembl:ENSG00000163554(gene)|ensembl:ENST00000643759(transcript)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0006779"(porphyrin-containing compound biosynthetic process)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008091"(spectrin)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0014731"(spectrin-associated cytoskeleton)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030424"(axon)|interpro:IPR018159|interpro:IPR036028|mint:P02549|rcsb pdb:1OWA|rcsb pdb:3LBX|rcsb pdb:5J4O|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6807878|interpro:IPR014837(EF-hand, Ca insensitive)|refseq:NP_003117.2|refseq:XP_011508218.1|dip:DIP-17031N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2i|comment:proteins found in  >500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:ypX1j52WRHo4kBjtDJWfSAF99949606	rigid:Qi21map1X/sbtiubKv4QoFpYJFs	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426379|imex:IM-26158-31	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure2, supp fig 2i|comment:proteins found in  >500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:Qi21map1X/sbtiubKv4QoFpYJFs	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P29972	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	-	-	-	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P02730	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P50895	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-10212133|uniprotkb:A8MYF9|uniprotkb:Q86VC7|uniprotkb:A9YWT6|uniprotkb:A9YWT5|ensembl:ENSP00000270233	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:bcam_human(display_long)|uniprotkb:BCAM(gene name)|psi-mi:BCAM(display_short)|uniprotkb:Auberger B antigen(gene name synonym)|uniprotkb:B-CAM cell surface glycoprotein(gene name synonym)|uniprotkb:F8/G253 antigen(gene name synonym)|uniprotkb:LU(gene name synonym)|uniprotkb:Lutheran antigen(gene name synonym)|uniprotkb:Lutheran blood group glycoprotein(gene name synonym)|uniprotkb:MSK19(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_001013275.1|refseq:NP_005572.2|ensembl:ENSG00000187244(gene)|ensembl:ENST00000270233(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005055"(laminin receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0043236"(laminin binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:2PET|rcsb pdb:2PF6	-	-	-	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:x0+dyVBq4nocOVEnSdGdWpXqpx89606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P04406	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-354056|uniprotkb:P00354|uniprotkb:Q53X65|uniprotkb:E7EUT4|ensembl:ENSP00000229239|ensembl:ENSP00000380068|ensembl:ENSP00000380070	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:g3p_human(display_long)|uniprotkb:GAPDH(gene name)|psi-mi:GAPDH(display_short)|uniprotkb:OK/SW-cl.12(orf name)|uniprotkb:CDABP0047(orf name)|uniprotkb:GAPD(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase GAPDH(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_002037.2|refseq:NP_001243728.1|refseq:NP_001276674.1|refseq:NP_001276675.1|dip:DIP-32521N|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0035605"(peptidyl-cysteine S-nitrosylase activity)|go:"GO:0035606"(peptidyl-cysteine S-trans-nitrosylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050661"(NADP binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051287"(NAD binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097452"(GAIT complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006424(Glyceraldehyde-3-phosphate dehydrogenase, type I)|interpro:IPR020828|interpro:IPR020829|interpro:IPR020830|interpro:IPR020831|interpro:IPR036291|mint:P04406|rcsb pdb:1U8F|rcsb pdb:1ZNQ|rcsb pdb:2FEH|rcsb pdb:3GPD|rcsb pdb:4WNC|rcsb pdb:4WNI|rcsb pdb:6ADE|rcsb pdb:6M61|rcsb pdb:6YND|rcsb pdb:6YNE|rcsb pdb:6YNF|rcsb pdb:6YNH|reactome:R-HSA-70171|reactome:R-HSA-70263|rcsb pdb:6IQ6|ensembl:ENSG00000111640(gene)|ensembl:ENST00000229239(transcript)|ensembl:ENST00000396859(transcript)|ensembl:ENST00000396861(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004365"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0008017"(microtubule binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0031640"(killing of cells of another organism)	-	-	-	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:9YENN/dfKl/d0tJtfFyQp2o8eAc9606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P11166	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:Q9NP59	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-725153|uniprotkb:Q7Z4F8|uniprotkb:Q8IVB2|uniprotkb:Q9NRL0|uniprotkb:Q6FI62|ensembl:ENSP00000261024	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:s40a1_human(display_long)|uniprotkb:Ferroportin-1(gene name synonym)|uniprotkb:Iron-regulated transporter 1(gene name synonym)|uniprotkb:SLC40A1(gene name)|psi-mi:SLC40A1(display_short)|uniprotkb:FPN1(gene name synonym)|uniprotkb:IREG1(gene name synonym)|uniprotkb:SLC11A3(gene name synonym)|uniprotkb:MSTP079(orf name)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_055400.1|ensembl:ENSG00000138449(gene)|ensembl:ENST00000261024(transcript)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1903988"(iron ion export across plasma membrane)|interpro:IPR009716(Ferroportin1)|interpro:IPR036259|mint:Q9NP59|rcsb pdb:6W4S|rcsb pdb:6WBV|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-5655799|reactome:R-HSA-917937	-	-	-	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:0SUoNbS3VZY+7J/6QMI96UaPOiI9606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P04075	uniprotkb:P27105	intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426431|imex:IM-26158-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:Figure 3D, supp fig 3|comment:proteins found in both  300 and 500 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/11	rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:cxX7DjZb0hPicUivZHLRkJgv+QI	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P23634	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P02730	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P16452	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1182496|uniprotkb:Q4VB97|uniprotkb:Q4KKX0|ensembl:ENSP00000396616	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:epb42_human(display_long)|uniprotkb:EPB42(gene name)|psi-mi:EPB42(display_short)|uniprotkb:E42P(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_000110.2|refseq:NP_001107606.1|refseq:XP_011519653.1|refseq:XP_011519651.1|refseq:XP_011519652.1|ensembl:ENSG00000166947(gene)|ensembl:ENST00000441366(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0048536"(spleen development)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:3HojdnCHcXhXVejly3k9UPytmh89606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:O75955	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q14254	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P11166	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q14773	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1222232|uniprotkb:Q14771|uniprotkb:Q14772|uniprotkb:Q16375|uniprotkb:A0M8X2|uniprotkb:Q9BWR0|ensembl:ENSP00000370147	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:icam4_human(display_long)|uniprotkb:ICAM4(gene name)|psi-mi:ICAM4(display_short)|uniprotkb:LW(gene name synonym)|uniprotkb:Landsteiner-Wiener blood group glycoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_001535.1|refseq:NP_001034221.1|ensembl:ENSG00000105371(gene)|ensembl:ENST00000380770(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-216083	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:JDyu0Pl9b58ZxL07c+7AAmemhWs9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q99808	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-347907|uniprotkb:Q5T9W9|uniprotkb:B3KQV7|uniprotkb:Q9UJY2|uniprotkb:B3KQY5|ensembl:ENSP00000360773|ensembl:ENSP00000360778|ensembl:ENSP00000360789|ensembl:ENSP00000360820|ensembl:ENSP00000377427|ensembl:ENSP00000498610|ensembl:ENSP00000498747|ensembl:ENSP00000499107	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:s29a1_human(display_long)|uniprotkb:SLC29A1(gene name)|psi-mi:SLC29A1(display_short)|uniprotkb:ENT1(gene name synonym)|uniprotkb:Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter(gene name synonym)|uniprotkb:Nucleoside transporter, es-type(gene name synonym)|uniprotkb:Solute carrier family 29 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_001291391.1|refseq:NP_001291392.1|refseq:NP_001291394.1|refseq:NP_001291395.1|refseq:NP_001071643.1|refseq:NP_001071645.1|refseq:XP_005248935.1|refseq:XP_005248936.1|refseq:XP_005248937.1|refseq:XP_005248938.1|refseq:XP_005248939.1|ensembl:ENSG00000112759(gene)|ensembl:ENST00000371708(transcript)|ensembl:ENST00000371713(transcript)|ensembl:ENST00000371724(transcript)|ensembl:ENST00000371755(transcript)|ensembl:ENST00000393844(transcript)|ensembl:ENST00000651428(transcript)|ensembl:ENST00000652453(transcript)|ensembl:ENST00000652680(transcript)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007595"(lactation)|go:"GO:0015211"(purine nucleoside transmembrane transporter activity)|go:"GO:0015213"(uridine transmembrane transporter activity)|go:"GO:0015858"(nucleoside transport)|go:"GO:0015860"(purine nucleoside transmembrane transport)|go:"GO:0015862"(uridine transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030431"(sleep)|go:"GO:0032238"(adenosine transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072531"(pyrimidine-containing compound transmembrane transport)|go:"GO:0080122"(AMP transmembrane transporter activity)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098810"(neurotransmitter reuptake)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901642"(nucleoside transmembrane transport)|interpro:IPR002259(Delayed-early response protein/equilibrative nucleoside transporter)|interpro:IPR030195|interpro:IPR034764|interpro:IPR036259|mint:Q99808|rcsb pdb:6OB6|go:"GO:0001504"(neurotransmitter uptake)|rcsb pdb:6OB7|reactome:R-HSA-83936|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005337"(nucleoside transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:whdAbkkAMjI+UBbbf52FncxXtb09606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q9NP59	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-725153|uniprotkb:Q7Z4F8|uniprotkb:Q8IVB2|uniprotkb:Q9NRL0|uniprotkb:Q6FI62|ensembl:ENSP00000261024	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:s40a1_human(display_long)|uniprotkb:Ferroportin-1(gene name synonym)|uniprotkb:Iron-regulated transporter 1(gene name synonym)|uniprotkb:SLC40A1(gene name)|psi-mi:SLC40A1(display_short)|uniprotkb:FPN1(gene name synonym)|uniprotkb:IREG1(gene name synonym)|uniprotkb:SLC11A3(gene name synonym)|uniprotkb:MSTP079(orf name)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_055400.1|ensembl:ENSG00000138449(gene)|ensembl:ENST00000261024(transcript)|go:"GO:0005381"(iron ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0015093"(ferrous iron transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017046"(peptide hormone binding)|go:"GO:0034755"(iron ion transmembrane transport)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1903988"(iron ion export across plasma membrane)|interpro:IPR009716(Ferroportin1)|interpro:IPR036259|mint:Q9NP59|rcsb pdb:6W4S|rcsb pdb:6WBV|reactome:R-HSA-425410|reactome:R-HSA-5619049|reactome:R-HSA-5619060|reactome:R-HSA-5655799|reactome:R-HSA-917937	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:0SUoNbS3VZY+7J/6QMI96UaPOiI9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P27105	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426469|imex:IM-26158-33	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:Figure 4, supp fig 4|comment:"proteins found in  >500 kDa band (blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:FMCmZhdodXghsoCvC+QsxdFxQFg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:P02730	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:Q08722	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-1268321|uniprotkb:Q53Y71|uniprotkb:Q96A60|uniprotkb:A8K198|uniprotkb:D3DN59|ensembl:ENSP00000355361	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:cd47_human(display_long)|uniprotkb:CD47(gene name)|psi-mi:CD47(display_short)|uniprotkb:MER6(gene name synonym)|uniprotkb:Integrin-associated protein(gene name synonym)|uniprotkb:Antigenic surface determinant protein OA3(gene name synonym)|uniprotkb:Protein MER6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	refseq:NP_001768.1|refseq:NP_942088.1|dip:DIP-39948N|ensembl:ENSG00000196776(gene)|ensembl:ENST00000361309(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904669"(ATP export)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:2000439"(positive regulation of monocyte extravasation)|interpro:IPR006704(CD47 integrin associated protein)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013147(CD47 transmembrane)|interpro:IPR013270(CD47 immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037805|rcsb pdb:2JJS|rcsb pdb:2JJT|rcsb pdb:2VSC|rcsb pdb:4CMM|rcsb pdb:4KJY|rcsb pdb:5IWL|rcsb pdb:5TZ2|rcsb pdb:5TZT|rcsb pdb:5TZU|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-391160|reactome:R-HSA-6798695|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:2hhmwvfeDFe7KHXzsBOJkjo2pjk9606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:O75955	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:Q14254	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:P11166	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:Q99808	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-347907|uniprotkb:Q5T9W9|uniprotkb:B3KQV7|uniprotkb:Q9UJY2|uniprotkb:B3KQY5|ensembl:ENSP00000360773|ensembl:ENSP00000360778|ensembl:ENSP00000360789|ensembl:ENSP00000360820|ensembl:ENSP00000377427|ensembl:ENSP00000498610|ensembl:ENSP00000498747|ensembl:ENSP00000499107	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:s29a1_human(display_long)|uniprotkb:SLC29A1(gene name)|psi-mi:SLC29A1(display_short)|uniprotkb:ENT1(gene name synonym)|uniprotkb:Equilibrative nitrobenzylmercaptopurine riboside-sensitive nucleoside transporter(gene name synonym)|uniprotkb:Nucleoside transporter, es-type(gene name synonym)|uniprotkb:Solute carrier family 29 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	refseq:NP_001291391.1|refseq:NP_001291392.1|refseq:NP_001291394.1|refseq:NP_001291395.1|refseq:NP_001071643.1|refseq:NP_001071645.1|refseq:XP_005248935.1|refseq:XP_005248936.1|refseq:XP_005248937.1|refseq:XP_005248938.1|refseq:XP_005248939.1|ensembl:ENSG00000112759(gene)|ensembl:ENST00000371708(transcript)|ensembl:ENST00000371713(transcript)|ensembl:ENST00000371724(transcript)|ensembl:ENST00000371755(transcript)|ensembl:ENST00000393844(transcript)|ensembl:ENST00000651428(transcript)|ensembl:ENST00000652453(transcript)|ensembl:ENST00000652680(transcript)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0007595"(lactation)|go:"GO:0015211"(purine nucleoside transmembrane transporter activity)|go:"GO:0015213"(uridine transmembrane transporter activity)|go:"GO:0015858"(nucleoside transport)|go:"GO:0015860"(purine nucleoside transmembrane transport)|go:"GO:0015862"(uridine transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030431"(sleep)|go:"GO:0032238"(adenosine transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072531"(pyrimidine-containing compound transmembrane transport)|go:"GO:0080122"(AMP transmembrane transporter activity)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098810"(neurotransmitter reuptake)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1901642"(nucleoside transmembrane transport)|interpro:IPR002259(Delayed-early response protein/equilibrative nucleoside transporter)|interpro:IPR030195|interpro:IPR034764|interpro:IPR036259|mint:Q99808|rcsb pdb:6OB6|go:"GO:0001504"(neurotransmitter uptake)|rcsb pdb:6OB7|reactome:R-HSA-83936|go:"GO:0005326"(neurotransmitter transmembrane transporter activity)|go:"GO:0005337"(nucleoside transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:whdAbkkAMjI+UBbbf52FncxXtb09606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:P27105	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P23634	uniprotkb:Q13336	intact:EBI-1174388|uniprotkb:Q13450|uniprotkb:Q13452|uniprotkb:Q13455|uniprotkb:Q16817|uniprotkb:Q7Z3S1|uniprotkb:B1APW6|uniprotkb:B1APW5	intact:EBI-16356018|ensembl:ENSP00000318546|ensembl:ENSP00000465702|ensembl:ENSP00000470476|uniprotkb:A8K0P3|uniprotkb:B3KR62|uniprotkb:B3KVX3|uniprotkb:C9EHF2|uniprotkb:Q86VM5	psi-mi:at2b4_human(display_long)|uniprotkb:Plasma membrane calcium ATPase isoform 4(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 4(gene name synonym)|uniprotkb:Matrix-remodeling-associated protein 1(gene name synonym)|uniprotkb:ATP2B4(gene name)|psi-mi:ATP2B4(display_short)|uniprotkb:ATP2B2(gene name synonym)|uniprotkb:MXRA1(gene name synonym)	psi-mi:ut1_human(display_long)|uniprotkb:SLC14A1(gene name)|psi-mi:SLC14A1(display_short)|uniprotkb:HUT11(gene name synonym)|uniprotkb:JK(gene name synonym)|uniprotkb:RACH1(gene name synonym)|uniprotkb:Solute carrier family 14 member 1(gene name synonym)|uniprotkb:UT1(gene name synonym)|uniprotkb:UTE(gene name synonym)|uniprotkb:Urea transporter, erythrocyte(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426520|imex:IM-26158-41	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001396.1|refseq:NP_001675.3|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010751"(negative regulation of nitric oxide mediated signal transduction)|go:"GO:0014832"(urinary bladder smooth muscle contraction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0030018"(Z disc)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0036126"(sperm flagellum)|go:"GO:0036487"(nitric-oxide synthase inhibitor activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097228"(sperm principal piece)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098703"(calcium ion import across plasma membrane)|go:"GO:0098736"(negative regulation of the force of heart contraction)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140199"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900082"(negative regulation of arginine catabolic process)|go:"GO:1901660"(calcium ion export)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902548"(negative regulation of cellular response to vascular endothelial growth factor stimulus)|go:"GO:1902806"(regulation of cell cycle G1/S phase transition)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903249"(negative regulation of citrulline biosynthetic process)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1905145"(cellular response to acetylcholine)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|rcsb pdb:1CFF|rcsb pdb:2KNE|reactome:R-HSA-418359|reactome:R-HSA-5578775|reactome:R-HSA-936837|mint:P23634|dip:DIP-6128N	ensembl:ENSG00000141469(gene)|ensembl:ENST00000321925(transcript)|ensembl:ENST00000586142(transcript)|ensembl:ENST00000586951(transcript)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0015204"(urea transmembrane transporter activity)|go:"GO:0015265"(urea channel activity)|go:"GO:0015840"(urea transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0055085"(transmembrane transport)|go:"GO:0071918"(urea transmembrane transport)|interpro:IPR004937(Urea transporter)|interpro:IPR029020|rcsb pdb:6QD5|reactome:R-HSA-425366|dip:DIP-60049N|refseq:NP_001122060.3|refseq:NP_001139508.2|refseq:NP_001139509.1|refseq:NP_056949.4	-	-	-	figure legend:Figure 4, supp fig 4i|comment:"proteins found in  500 kDa band (brown)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:XAjzRea7vq4vsbCVKdZRYIWvfBM9606	rogid:DyDCqQdQ14nSdOOovEoEI0ODoq09606	rigid:m+agB5RLMxIKJh5gQGld1xezo30	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:O75955	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426555|imex:IM-26158-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4ii|comment:"proteins found in  70 kDa band (green)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:ZVDA+X+RgM43V2DWgx+vRHiv21k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q14254	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426555|imex:IM-26158-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4ii|comment:"proteins found in  70 kDa band (green)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:ZVDA+X+RgM43V2DWgx+vRHiv21k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426555|imex:IM-26158-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4ii|comment:"proteins found in  70 kDa band (green)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:ZVDA+X+RgM43V2DWgx+vRHiv21k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426555|imex:IM-26158-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4ii|comment:"proteins found in  70 kDa band (green)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:ZVDA+X+RgM43V2DWgx+vRHiv21k	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P02730	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q08722	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1268321|uniprotkb:Q53Y71|uniprotkb:Q96A60|uniprotkb:A8K198|uniprotkb:D3DN59|ensembl:ENSP00000355361	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:cd47_human(display_long)|uniprotkb:CD47(gene name)|psi-mi:CD47(display_short)|uniprotkb:MER6(gene name synonym)|uniprotkb:Integrin-associated protein(gene name synonym)|uniprotkb:Antigenic surface determinant protein OA3(gene name synonym)|uniprotkb:Protein MER6(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_001768.1|refseq:NP_942088.1|dip:DIP-39948N|ensembl:ENSG00000196776(gene)|ensembl:ENST00000361309(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0035579"(specific granule membrane)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904669"(ATP export)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:2000439"(positive regulation of monocyte extravasation)|interpro:IPR006704(CD47 integrin associated protein)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013147(CD47 transmembrane)|interpro:IPR013270(CD47 immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR037805|rcsb pdb:2JJS|rcsb pdb:2JJT|rcsb pdb:2VSC|rcsb pdb:4CMM|rcsb pdb:4KJY|rcsb pdb:5IWL|rcsb pdb:5TZ2|rcsb pdb:5TZT|rcsb pdb:5TZU|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-391160|reactome:R-HSA-6798695|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)	-	-	-	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:2hhmwvfeDFe7KHXzsBOJkjo2pjk9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:O75955	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q14254	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	-	-	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P11166	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q14773	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1222232|uniprotkb:Q14771|uniprotkb:Q14772|uniprotkb:Q16375|uniprotkb:A0M8X2|uniprotkb:Q9BWR0|ensembl:ENSP00000370147	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:icam4_human(display_long)|uniprotkb:ICAM4(gene name)|psi-mi:ICAM4(display_short)|uniprotkb:LW(gene name synonym)|uniprotkb:Landsteiner-Wiener blood group glycoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_001535.1|refseq:NP_001034221.1|ensembl:ENSG00000105371(gene)|ensembl:ENST00000380770(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-216083	-	-	-	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:JDyu0Pl9b58ZxL07c+7AAmemhWs9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P27105	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426572|imex:IM-26158-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:Figure 4, supp fig 4iii|comment:"proteins found in  65 kDa band (purple)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/09	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:no+vQqv4t8GyKw/NgG0ofe2ZJc4	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P02730	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426582|imex:IM-26158-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	-	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	figure legend:Figure 4, supp fig 4iv|comment:"proteins found in = 60 kDa band (medium blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rigid:XOwqIo1y0hBILnX1fT5zeGaY75Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:O75955	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426582|imex:IM-26158-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	-	-	figure legend:Figure 4, supp fig 4iv|comment:"proteins found in = 60 kDa band (medium blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:XOwqIo1y0hBILnX1fT5zeGaY75Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q14254	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426582|imex:IM-26158-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	-	-	figure legend:Figure 4, supp fig 4iv|comment:"proteins found in = 60 kDa band (medium blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:XOwqIo1y0hBILnX1fT5zeGaY75Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P11166	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426582|imex:IM-26158-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	-	-	figure legend:Figure 4, supp fig 4iv|comment:"proteins found in = 60 kDa band (medium blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:XOwqIo1y0hBILnX1fT5zeGaY75Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:Q14773	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1222232|uniprotkb:Q14771|uniprotkb:Q14772|uniprotkb:Q16375|uniprotkb:A0M8X2|uniprotkb:Q9BWR0|ensembl:ENSP00000370147	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:icam4_human(display_long)|uniprotkb:ICAM4(gene name)|psi-mi:ICAM4(display_short)|uniprotkb:LW(gene name synonym)|uniprotkb:Landsteiner-Wiener blood group glycoprotein(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426582|imex:IM-26158-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_001535.1|refseq:NP_001034221.1|ensembl:ENSG00000105371(gene)|ensembl:ENST00000380770(transcript)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR003987(Intercellular adhesion molecule/vascular cell adhesion molecule, N-terminal)|interpro:IPR013768(Intercellular adhesion molecule, N-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|reactome:R-HSA-198933|reactome:R-HSA-216083	-	-	-	figure legend:Figure 4, supp fig 4iv|comment:"proteins found in = 60 kDa band (medium blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:JDyu0Pl9b58ZxL07c+7AAmemhWs9606	rigid:XOwqIo1y0hBILnX1fT5zeGaY75Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P29972	uniprotkb:P27105	intact:EBI-745213|uniprotkb:Q8TBI5|uniprotkb:Q8TDC1|uniprotkb:B5BU39|ensembl:ENSP00000311165|ensembl:ENSP00000498672|uniprotkb:F5GY19|uniprotkb:E7EM69|uniprotkb:E9PC21	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:aqp1_human(display_long)|uniprotkb:Aquaporin-CHIP(gene name synonym)|uniprotkb:Water channel protein for red blood cells and kidney proximal tubule(gene name synonym)|uniprotkb:Urine water channel(gene name synonym)|uniprotkb:AQP1(gene name)|psi-mi:AQP1(display_short)|uniprotkb:CHIP28(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426582|imex:IM-26158-42	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_932766.1|ensembl:ENSG00000240583(gene)|ensembl:ENST00000311813(transcript)|ensembl:ENST00000652696(transcript)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0003097"(renal water transport)|go:"GO:0005223"(intracellular cGMP-activated cation channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005372"(water transmembrane transporter activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006833"(water transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009992"(cellular water homeostasis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015168"(glycerol transmembrane transporter activity)|go:"GO:0015250"(water channel activity)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0015696"|go:"GO:0015793"(glycerol transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030184"(nitric oxide transmembrane transporter activity)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030950"(establishment or maintenance of actin cytoskeleton polarity)|go:"GO:0031526"(brush border membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033326"(cerebrospinal fluid secretion)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035377"(transepithelial water transport)|go:"GO:0035378"(carbon dioxide transmembrane transport)|go:"GO:0035379"(carbon dioxide transmembrane transporter activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042476"(odontogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046878"(positive regulation of saliva secretion)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071241"(cellular response to inorganic substance)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0085018"(obsolete maintenance of symbiont-containing vacuole by host)|interpro:IPR000425(Major intrinsic protein)|interpro:IPR022357|interpro:IPR023271|interpro:IPR023274|interpro:IPR034294|rcsb pdb:1FQY|rcsb pdb:1H6I|rcsb pdb:1IH5|rcsb pdb:4CSK|rcsb pdb:6POJ|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-432040|reactome:R-HSA-432047|dip:DIP-29607N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	-	-	figure legend:Figure 4, supp fig 4iv|comment:"proteins found in = 60 kDa band (medium blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:0y0L/lmXZ68WhUSetgKRrSFdT1I9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:XOwqIo1y0hBILnX1fT5zeGaY75Q	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16589432|imex:IM-26158-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4v|comment:"proteins found in = 20 kDa band (pale blue)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/10	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:KbFORtsvxxPWqtGOuxS1a3mwRKw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:O75955	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-603643|ensembl:ENSP00000365569|ensembl:ENSP00000372873|ensembl:ENSP00000373056|ensembl:ENSP00000388861|ensembl:ENSP00000391438|uniprotkb:Q969J8|uniprotkb:Q9UHW1|uniprotkb:Q9UNV8|uniprotkb:B4DVY7	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot1_human(display_long)|uniprotkb:FLOT1(gene name)|psi-mi:FLOT1(display_short)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16589443|imex:IM-26158-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001931"(uropod)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007409"(axonogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030027"(lamellipodium)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033227"(dsRNA transport)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044854"(plasma membrane raft assembly)|go:"GO:0045121"(membrane raft)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051580"(regulation of neurotransmitter uptake)|go:"GO:0060355"(positive regulation of cell adhesion molecule production)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071360"(cellular response to exogenous dsRNA)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098691"(dopaminergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1901890"(positive regulation of cell junction assembly)|go:"GO:1903044"(protein localization to membrane raft)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR036013|mint:O75955|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000137312(gene)|ensembl:ENSG00000206379(gene)|ensembl:ENSG00000206480(gene)|ensembl:ENSG00000230143(gene)|ensembl:ENSG00000232280(gene)|ensembl:ENST00000376389(transcript)|ensembl:ENST00000383382(transcript)|ensembl:ENST00000383562(transcript)|ensembl:ENST00000436822(transcript)|ensembl:ENST00000444632(transcript)|refseq:NP_005794.1|refseq:NP_001305804.1|refseq:XP_005248837.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4vi|comment:"proteins found in = 30 kDa band (orange)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/10	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:wRw9QYIRNJb0ZQtwjm/D+ydci8k9606	rigid:R+fiqpVhqXX7jMrSBCK8MeatdZg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16589443|imex:IM-26158-48	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 4, supp fig 4vi|comment:"proteins found in = 30 kDa band (orange)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/10	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:R+fiqpVhqXX7jMrSBCK8MeatdZg	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426603|imex:IM-26158-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5B-F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:WB6XCZZtARQzLCFp8ymR6YvGOF0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426603|imex:IM-26158-44	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5B-F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:WB6XCZZtARQzLCFp8ymR6YvGOF0	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16589455|imex:IM-26158-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5B-Fi|comment:800 kDa band|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/11/10	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:KbFORtsvxxPWqtGOuxS1a3mwRKw	false	-	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P02730	uniprotkb:Q14254	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426622|imex:IM-26158-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5A|comment:proteins from DRMs|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	rigid:UeLEhl14fXokY1E431ozGFnkZY0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426622|imex:IM-26158-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5A|comment:proteins from DRMs|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:UeLEhl14fXokY1E431ozGFnkZY0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426622|imex:IM-26158-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5A|comment:proteins from DRMs|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:UeLEhl14fXokY1E431ozGFnkZY0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P02724	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-702665|uniprotkb:Q9BS51|uniprotkb:A8K3E6|uniprotkb:B8Q182|uniprotkb:B8Q185	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:glpa_human(display_long)|uniprotkb:PAS-2(gene name synonym)|uniprotkb:Sialoglycoprotein alpha(gene name synonym)|uniprotkb:MN sialoglycoprotein(gene name synonym)|uniprotkb:GYPA(gene name)|psi-mi:GYPA(display_short)|uniprotkb:GPA(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426630|imex:IM-26158-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_002090.4|interpro:IPR001195(Glycophorin A and B)|interpro:IPR018938|rcsb pdb:1AFO|rcsb pdb:1MSR|rcsb pdb:2KPE|rcsb pdb:2KPF|rcsb pdb:5EH4|rcsb pdb:5EH6|refseq:NP_001295119.1|refseq:XP_016863624.1|reactome:R-HSA-202733|go:"GO:0001618"(virus receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5A-2|comment:proteins from non- DRMs|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:QYkwVSmE7sIqAeoopqJRWvEu1PI9606	rigid:bFRn18ZEBP6pa3WLeV9p9FZfIwk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P11166	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-717153|uniprotkb:A8K9S6|uniprotkb:O75535|uniprotkb:Q147X2|uniprotkb:B2R620|uniprotkb:D3DPX0|uniprotkb:Q0P512|ensembl:ENSP00000416293	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:gtr1_human(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:HepG2 glucose transporter(gene name synonym)|uniprotkb:SLC2A1(gene name)|psi-mi:SLC2A1(display_short)|uniprotkb:GLUT1(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426630|imex:IM-26158-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_006507.2|ensembl:ENSG00000117394(gene)|ensembl:ENST00000426263(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019852"(L-ascorbic acid metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0072562"(blood microparticle)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|mint:P11166|rcsb pdb:1SUK|rcsb pdb:4PYP|rcsb pdb:5EQG|rcsb pdb:5EQH|rcsb pdb:5EQI|rcsb pdb:6THA|reactome:R-HSA-189200|reactome:R-HSA-196836|reactome:R-HSA-422356|reactome:R-HSA-5619043|reactome:R-HSA-5653890|dip:DIP-23N	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5A-2|comment:proteins from non- DRMs|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:72DLUG1CFkqcf92goIZBZ4+zuls9606	rigid:bFRn18ZEBP6pa3WLeV9p9FZfIwk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P02730	uniprotkb:P27105	intact:EBI-7576138|uniprotkb:Q9UDJ1|uniprotkb:Q1ZZ45|uniprotkb:G4V2I6|uniprotkb:Q4VB84|uniprotkb:Q4KKW9|uniprotkb:P78487|intact:MINT-1344291|uniprotkb:Q9UCY7|ensembl:ENSP00000262418	intact:EBI-1211440|uniprotkb:Q14087|uniprotkb:Q15609|uniprotkb:Q5VX96|uniprotkb:Q96FK4|uniprotkb:B1AM77|ensembl:ENSP00000286713	psi-mi:b3at_human(display_long)|uniprotkb:SLC4A1(gene name)|psi-mi:SLC4A1(display_short)|uniprotkb:AE1(gene name synonym)|uniprotkb:DI(gene name synonym)|uniprotkb:EPB3(gene name synonym)|uniprotkb:Anion exchange protein 1(gene name synonym)|uniprotkb:Solute carrier family 4 member 1(gene name synonym)	psi-mi:stom_human(display_long)|uniprotkb:STOM(gene name)|psi-mi:STOM(display_short)|uniprotkb:BND7(gene name synonym)|uniprotkb:EPB72(gene name synonym)|uniprotkb:Protein 7.2b(gene name synonym)|uniprotkb:Erythrocyte band 7 integral membrane protein(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 7.2(gene name synonym)	psi-mi:"MI:0029"(cosedimentation through density gradient)	Rungaldier et al. (2013)	imex:IM-26158|pubmed:23219802	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-16426630|imex:IM-26158-39	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000333.1|refseq:XP_005257650.1|ensembl:ENSG00000004939(gene)|ensembl:ENST00000262418(transcript)|go:"GO:0007596"(blood coagulation)|go:"GO:0005452"(inorganic anion exchanger activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006820"(anion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0006873"(cellular ion homeostasis)|go:"GO:0008509"(anion transmembrane transporter activity)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015106"(bicarbonate transmembrane transporter activity)|go:"GO:0015108"(chloride transmembrane transporter activity)|go:"GO:0015301"("anion:anion antiporter activity")|go:"GO:0015701"(bicarbonate transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0017121"(plasma membrane phospholipid scrambling)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030018"(Z disc)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045852"(pH elevation)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050801"(ion homeostasis)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0055085"(transmembrane transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1904539"(negative regulation of glycolytic process through fructose-6-phosphate)|interpro:IPR001717(Anion exchange protein)|interpro:IPR002977(Anion exchange protein 1)|interpro:IPR003020(Bicarbonate transporter, eukaryotic)|interpro:IPR011531(Bicarbonate transporter, C-terminal)|interpro:IPR013769(Bicarbonate transporter, cytoplasmic)|interpro:IPR016152(Phosphotransferase/anion transporter)|interpro:IPR018241|mint:P02730|rcsb pdb:1BH7|rcsb pdb:1BNX|rcsb pdb:1BTQ|rcsb pdb:1BTR|rcsb pdb:1BTS|rcsb pdb:1BTT|rcsb pdb:1BZK|rcsb pdb:1HYN|rcsb pdb:2BTA|rcsb pdb:2BTB|rcsb pdb:3BTB|rcsb pdb:4KY9|rcsb pdb:4YZF|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-425381|reactome:R-HSA-5619050|dip:DIP-42428N	refseq:NP_004090.4|refseq:NP_937837.1|ensembl:ENSG00000148175(gene)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENST00000286713(transcript)|go:"GO:0016020"(membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048524"(positive regulation of viral process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901585"(regulation of acid-sensing ion channel activity)|interpro:IPR001107(Band 7 protein)|interpro:IPR001972(Stomatin)|interpro:IPR018080|interpro:IPR028515|interpro:IPR036013|interpro:IPR043202|mint:P27105|reactome:R-HSA-2672351|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409	-	function:"Defects in SLC4A1 are the cause of elliptocytosis type 4 (EL4) [MIM:109270]. EL4 is a Rhesus-unlinked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape"|function:"Defects in SLC4A1 are the cause of autosomal dominant distal renal tubular acidosis (dRTA) [MIM:179800]. This disease is characterized by reduced ability to acidify urine, variable hyperchloremic hypokalemic metabolic acidosis, nephrocalcinosis, and nephrolithiasis"|function:"Defects in SLC4A1 are the cause of autosomal recessive distal renal tubular acidosis (dRTA) [MIM:611590]"|function:"Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1:1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin"|comment:mint|function:"Defects in SLC4A1 are a cause of hereditary spherocytosis (HS) [MIM:109270]. HS is a hematologic disorder leading to chronic hemolytic anemia and characterized by numerous abnormally shaped erythrocytes which are generally spheroidal"	-	figure legend:Figure 5A-2|comment:proteins from non- DRMs|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-erythrocyte)|taxid:9606(Homo sapiens)	-	2017/09/29	2017/10/12	rogid:rmDsGx5dB4bRCaXClZk+AptTR6M9606	rogid:vN/5Kc8T+vO90Hk4N3RHD/u0pWc9606	rigid:bFRn18ZEBP6pa3WLeV9p9FZfIwk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)