#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8R4B8	uniprotkb:Q9EPB4	intact:EBI-6910832|uniprotkb:T1W2H6|ensembl:ENSMUSP00000078440|ensembl:ENSMUSP00000098707|uniprotkb:Q1JQ87|uniprotkb:Q1JQ88|uniprotkb:Q6JEL0	intact:EBI-6253348|ensembl:ENSMUSP00000033056|uniprotkb:Q9D2W9	psi-mi:nlrp3_mouse(display_long)|uniprotkb:Nlrp3(gene name)|psi-mi:Nlrp3(display_short)|uniprotkb:Cias1(gene name synonym)|uniprotkb:Mmig1(gene name synonym)|uniprotkb:Nalp3(gene name synonym)|uniprotkb:Pypaf1(gene name synonym)|uniprotkb:Cold autoinflammatory syndrome 1 protein homolog(gene name synonym)|uniprotkb:Cryopyrin(gene name synonym)|uniprotkb:Mast cell maturation-associated-inducible protein 1(gene name synonym)|uniprotkb:PYRIN-containing APAF1-like protein 1(gene name synonym)	psi-mi:asc_mouse(display_long)|uniprotkb:Pycard(gene name)|psi-mi:Pycard(display_short)|uniprotkb:Asc(gene name synonym)|uniprotkb:PYD and CARD domain-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lee et al. (2012)	pubmed:23143333|doi:10.1038/nature11588|imex:IM-20811	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-16023381|imex:IM-20811-1|dip:DIP-190573E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:2000321"(positive regulation of T-helper 17 cell differentiation)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR004020(Pyrin)|interpro:IPR007111(NACHT nucleoside triphosphatase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR029495|interpro:IPR032675|interpro:IPR041075|interpro:IPR041267|reactome:R-MMU-5689901|reactome:R-MMU-844456|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044546"(NLRP3 inflammasome complex assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0045471"(response to ethanol)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|refseq:XP_006532920.1|refseq:XP_006532921.1|ensembl:ENSMUSG00000032691(gene)|ensembl:ENSMUST00000079476(transcript)|ensembl:ENSMUST00000101148(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0042802"(identical protein binding)|refseq:NP_665826.1|dip:DIP-60132N	ensembl:ENSMUSG00000030793(gene)|ensembl:ENSMUST00000033056(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0002588"(positive regulation of antigen processing and presentation of peptide antigen via MHC class II)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0005138"(interleukin-6 receptor binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009617"(response to bacterium)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0017024"(myosin I binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032090"(Pyrin domain binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051607"(defense response to virus)|go:"GO:0061702"(inflammasome complex)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR004020(Pyrin)|interpro:IPR011029(DEATH-like)|interpro:IPR033516|rcsb pdb:2N1F|refseq:NP_075747.3|dip:DIP-27619N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2017/08/07	2017/08/10	rogid:GqOsZzWJZQ6lda0p7YFya/ZEllE10090	rogid:voh/LYBzHC1ZM83VF91HJfILfGU10090	rigid:+eIt5WHpkcN2JnnbYlafeW04CQk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)