#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UHF4 uniprotkb:Q6UXL0 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14022750|imex:IM-25677-1|wwpdb:4doh - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 - - - figure legend:Table S1|3d-resolution:2.8A|3d-r-factors:R Work 0.23 R Free 0.28|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/05 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rigid:FHAmIH/s/j7hSRpMymiacK4rU0Q false sufficient binding region:29-245|mutation:111-111,113-113 mutation:40-40,134-134|sufficient binding region:30-231 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHF4 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14022785 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0114"(x-ray crystallography) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14022750|imex:IM-25677-1|wwpdb:4doh - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:Table S1|3d-resolution:2.8A|3d-r-factors:R Work 0.23 R Free 0.28|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/05 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:FHAmIH/s/j7hSRpMymiacK4rU0Q false sufficient binding region:29-245|mutation:111-111,113-113 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9UHF4 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023030|imex:IM-25677-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 - - - figure legend:Fig 5B, 6F, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:319.0x10^-9(molar) 2017/02/23 2017/04/05 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rigid:FHAmIH/s/j7hSRpMymiacK4rU0Q false mutation:134-134,40-40|sufficient binding region:30-231|fc-igg tag:c-c sufficient binding region:29-245|mutation:111-111,113-113|mutation decreasing interaction strength:207-207,190-190,194-194 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14022785 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023030|imex:IM-25677-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:Fig 5B, 6F, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:319.0x10^-9(molar) 2017/02/23 2017/04/05 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:FHAmIH/s/j7hSRpMymiacK4rU0Q false mutation:134-134,40-40|sufficient binding region:30-231|fc-igg tag:c-c - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14022785 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14023063|imex:IM-25677-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:6D, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:687.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:/4DiZfbZ532RVLIlS8hfKLokvvY false mutation:134-134,40-40|sufficient binding region:30-231|fc-igg tag:c-c - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHF4 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14022785 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14023088|imex:IM-25677-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:6B, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:9.0x10^-6(mol) 2017/02/23 2017/04/06 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:Ut7rdbmLoI2o6/guOJkhqW793F8 false fc-igg tag:c-c|sufficient binding region:29-245|mutation:111-111,113-113 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHF4 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14022785 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023182|imex:IM-25677-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:Supp Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.07x10^-6(molar) 2017/02/23 2017/04/05 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:FHAmIH/s/j7hSRpMymiacK4rU0Q false sufficient binding region:29-245|mutation:111-111,113-113|fc-igg tag:c-c - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHF4 uniprotkb:Q6UXL0 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023182|imex:IM-25677-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 - - - figure legend:Supp Fig 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.07x10^-6(molar) 2017/02/23 2017/04/05 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rigid:FHAmIH/s/j7hSRpMymiacK4rU0Q false sufficient binding region:29-245|mutation:111-111,113-113|fc-igg tag:c-c sufficient binding region:30-231|mutation:134-134,40-40 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9UHD0-PRO_0000015379 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14023330 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9uhd0-pro_0000015379(display_long)|uniprotkb:Melanoma differentiation-associated protein-like protein(gene name synonym)|uniprotkb:IL19(gene name)|psi-mi:IL19(display_short)|uniprotkb:ZMDA1(gene name synonym)|uniprotkb:NG.1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023210|imex:IM-25677-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14023294(chain-parent) - - chain-seq-start:25|chain-seq-end:177 figure legend:Fig 6E, 5B, table S6|comment:This interaction is also shown in figure 5B, but it is not stated if an Fc tag was present on IL20R2, and no Kd value is given in Table S6.|comment:In Figure 5B no difference is shown between IL19 alone, and IL19 plus IL20R1 3M mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3121.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:7WSRQ9RqVTMjhha+6FbM5jjmKYE9606 rigid:REiDOn60tXj1Q7rHVWc6ED36J4A false sufficient binding region:30-231|mutation:40-40,134-134|fc-igg tag:c-c - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9UHF4 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023210|imex:IM-25677-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 - - - figure legend:Fig 6E, 5B, table S6|comment:This interaction is also shown in figure 5B, but it is not stated if an Fc tag was present on IL20R2, and no Kd value is given in Table S6.|comment:In Figure 5B no difference is shown between IL19 alone, and IL19 plus IL20R1 3M mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:3121.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rigid:REiDOn60tXj1Q7rHVWc6ED36J4A false sufficient binding region:30-231|mutation:40-40,134-134|fc-igg tag:c-c mutation decreasing interaction strength:207-207,190-190,194-194|sufficient binding region:29-245|mutation:111-111,113-113 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14022785 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14023258|imex:IM-25677-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:5B, table S6-row2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:870.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:/4DiZfbZ532RVLIlS8hfKLokvvY false mutation:134-134,40-40|sufficient binding region:30-231 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9UHD0-PRO_0000015379 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14023330 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9uhd0-pro_0000015379(display_long)|uniprotkb:Melanoma differentiation-associated protein-like protein(gene name synonym)|uniprotkb:IL19(gene name)|psi-mi:IL19(display_short)|uniprotkb:ZMDA1(gene name synonym)|uniprotkb:NG.1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14023283|imex:IM-25677-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14023294(chain-parent) - - chain-seq-start:25|chain-seq-end:177 figure legend:5B, table S6-row1|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:36.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:7WSRQ9RqVTMjhha+6FbM5jjmKYE9606 rigid:8I/8ii7m2h6m2DqKNZh4hxg47AE false mutation:134-134,40-40|sufficient binding region:30-231 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9UHD0-PRO_0000015379 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14023330 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9uhd0-pro_0000015379(display_long)|uniprotkb:Melanoma differentiation-associated protein-like protein(gene name synonym)|uniprotkb:IL19(gene name)|psi-mi:IL19(display_short)|uniprotkb:ZMDA1(gene name synonym)|uniprotkb:NG.1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-14023337|imex:IM-25677-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14023294(chain-parent) - - chain-seq-start:25|chain-seq-end:177 figure legend:6C, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:105.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:7WSRQ9RqVTMjhha+6FbM5jjmKYE9606 rigid:8I/8ii7m2h6m2DqKNZh4hxg47AE false fc-igg tag:c-c|mutation:134-134,40-40|sufficient binding region:30-231 - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q8N6P7 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023352|imex:IM-25677-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N - - - figure legend:6H, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1363.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606 rigid:iwRxIPD0h+N31eIxi/hVBa3LWcw false mutation:134-134,40-40|sufficient binding region:30-231|fc-igg tag:c-c sufficient binding region:?-? 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6UXL0 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14022785 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023352|imex:IM-25677-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:6H, table S6|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1363.0x10^-9(molar) 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:iwRxIPD0h+N31eIxi/hVBa3LWcw false mutation:134-134,40-40|sufficient binding region:30-231|fc-igg tag:c-c - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N6P7 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800 intact:EBI-14022785 psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023383|imex:IM-25677-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:Supp Fig 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.16x10^-6(molar) 2017/02/23 2017/04/06 rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:iwRxIPD0h+N31eIxi/hVBa3LWcw false sufficient binding region:?-? - 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8N6P7 uniprotkb:Q6UXL0 intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym) psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023383|imex:IM-25677-13 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 - - - figure legend:Supp Fig 5C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:1.16x10^-6(molar) 2017/02/23 2017/04/06 rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rigid:iwRxIPD0h+N31eIxi/hVBa3LWcw false sufficient binding region:?-? sufficient binding region:30-231|mutation:134-134,40-40 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UHF4 uniprotkb:Q9UHF4 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:"MI:0030"(cross-linking study) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023134|imex:IM-25677-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 - - - figure legend:Supp. fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/06 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rigid:Ut7rdbmLoI2o6/guOJkhqW793F8 false sufficient binding region:29-245|mutation:111-111,113-113 sufficient binding region:29-245|mutation:111-111,113-113 2 2 psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q9UHF4 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14022785 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0030"(cross-linking study) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023134|imex:IM-25677-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:Supp. fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/06 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:Ut7rdbmLoI2o6/guOJkhqW793F8 false sufficient binding region:29-245|mutation:111-111,113-113 - 2 2 psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q6UXL0 uniprotkb:Q9NYY1-PRO_0000015381 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14022785 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9nyy1-pro_0000015381(display_long)|uniprotkb:Cytokine Zcyto10(gene name synonym)|uniprotkb:IL20(gene name)|psi-mi:IL20(display_short)|uniprotkb:ZCYTO10(gene name synonym)|uniprotkb:UNQ852/PRO1801(orf name) psi-mi:"MI:0030"(cross-linking study) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023157|imex:IM-25677-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14022752(chain-parent) - - chain-seq-start:25|chain-seq-end:176 figure legend:Supp fig 4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/05 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:Y7Z8i+XKLk/V/tyUPfbKrGmK4Qk9606 rigid:/4DiZfbZ532RVLIlS8hfKLokvvY false mutation:40-40,134-134|sufficient binding region:30-231|fc-igg tag:c-c - 1 1 psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q6UXL0 uniprotkb:Q9UHD0-PRO_0000015379 intact:EBI-14022792|ensembl:ENSP00000328133|uniprotkb:B4DL40|uniprotkb:Q6P438|uniprotkb:Q8IYY5|uniprotkb:Q8TAJ7 intact:EBI-14023330 psi-mi:i20rb_human(display_long)|uniprotkb:Fibronectin type III domain containing 6(gene name synonym)|uniprotkb:IL-20R2(gene name synonym)|uniprotkb:UNQ557/PRO1114(orf name)|uniprotkb:IL20RB(gene name)|psi-mi:IL20RB(display_short)|uniprotkb:DIRS1(gene name synonym) psi-mi:q9uhd0-pro_0000015379(display_long)|uniprotkb:Melanoma differentiation-associated protein-like protein(gene name synonym)|uniprotkb:IL19(gene name)|psi-mi:IL19(display_short)|uniprotkb:ZMDA1(gene name synonym)|uniprotkb:NG.1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023404|imex:IM-25677-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0002765"(immune response-inhibiting signal transduction)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|ensembl:ENSG00000174564(gene)|ensembl:ENST00000329582(transcript)|go:"GO:0001808"(negative regulation of type IV hypersensitivity)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:4DOH|rcsb pdb:6DF3|reactome:R-HSA-8854691|refseq:NP_653318.2 intact:EBI-14023294(chain-parent) - - chain-seq-start:25|chain-seq-end:177 figure legend:Supp fig 4 A/B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/06 rogid:Q8tMw5LmDk9ecSdCVTB35TXf8kk9606 rogid:7WSRQ9RqVTMjhha+6FbM5jjmKYE9606 rigid:8I/8ii7m2h6m2DqKNZh4hxg47AE false mutation:40-40,134-134|sufficient binding region:30-231|fc-igg tag:c-c - 1 1 psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q9UHF4 uniprotkb:Q9UHF4 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:"MI:0030"(cross-linking study) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023421|imex:IM-25677-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 - - - figure legend:Supp. fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/06 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rigid:V5PT8xDL9kMLhG3xV5Q9I5foAJY false sufficient binding region:29-245|mutation:111-111,113-113 sufficient binding region:29-245|mutation:111-111,113-113 2 2 psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining) uniprotkb:Q9UHF4 uniprotkb:Q9UHD0-PRO_0000015379 intact:EBI-2933034|ensembl:ENSP00000314976|uniprotkb:Q14CW2|uniprotkb:Q6UWA9|uniprotkb:Q96SH8|uniprotkb:B4DLR5|uniprotkb:F5H675 intact:EBI-14023330 psi-mi:i20ra_human(display_long)|uniprotkb:IL20RA(gene name)|psi-mi:IL20RA(display_short)|uniprotkb:Cytokine receptor class-II member 8(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 8(gene name synonym)|uniprotkb:IL-20R1(gene name synonym)|uniprotkb:ZcytoR7(gene name synonym)|uniprotkb:UNQ681/PRO1315(orf name) psi-mi:q9uhd0-pro_0000015379(display_long)|uniprotkb:Melanoma differentiation-associated protein-like protein(gene name synonym)|uniprotkb:IL19(gene name)|psi-mi:IL19(display_short)|uniprotkb:ZMDA1(gene name synonym)|uniprotkb:NG.1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Logsdon et al. (2012) pubmed:22802649|imex:IM-25677 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14023421|imex:IM-25677-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000016402(gene)|ensembl:ENST00000316649(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR015713(Interleukin-20 receptor, alpha subunit)|interpro:IPR036116|rcsb pdb:4DOH|reactome:R-HSA-8854691|refseq:XP_011534206.1|refseq:NP_001265651.1|refseq:NP_001265652.1|refseq:NP_001265653.1|refseq:NP_055247.3 intact:EBI-14023294(chain-parent) - - chain-seq-start:25|chain-seq-end:177 figure legend:Supp. fig 4B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/02/23 2017/04/06 rogid:QgyJryAyx2wUbwmNEmVlA6YOuro9606 rogid:7WSRQ9RqVTMjhha+6FbM5jjmKYE9606 rigid:V5PT8xDL9kMLhG3xV5Q9I5foAJY false sufficient binding region:29-245|mutation:111-111,113-113 - 2 2 psi-mi:"MI:0816"(molecular weight estimation by staining) psi-mi:"MI:0816"(molecular weight estimation by staining)