#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q96JC1	uniprotkb:P36780	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	intact:EBI-13612615	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13612631|imex:IM-25807-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0005764"(lysosome)	-	-	figure legend:F7B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:Ni67F6PKBo6okfrC2lxQqiGBrOs	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P09496	uniprotkb:P36780	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	intact:EBI-13612615	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613037|imex:IM-25807-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0005634"(nucleus)	-	-	figure legend:F7C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:YSjvAGecsgvieu75ddW2y2OHZmU	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P06790	uniprotkb:P09496	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613078|imex:IM-25807-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	go:"GO:0005634"(nucleus)	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:F7C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rigid:JUo+vEosi1/R5EUDm0RhVhKJW4o	false	green fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P06790	uniprotkb:O95235	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613103|imex:IM-25807-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:F7D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:qhyaGHk2dtfTYMKKwlXwpBw/Kmo	false	green fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O95235	uniprotkb:P06423	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	intact:EBI-13613158	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613173|imex:IM-25807-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0005737"(cytoplasm)|go:"GO:0005634"(nucleus)	-	-	figure legend:F7D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rigid:nicRJqDSDvPVOo+XdtDBzzJq3Yw	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:O95235	uniprotkb:P06921	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	intact:EBI-13613195	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333923(hpv05)|taxid:333923(hpv05)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613211|imex:IM-25807-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0005634"(nucleus)	-	-	figure legend:F7D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rigid:mRF9Mr1220yyj1lU7coCFvOBJb8	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P06790	uniprotkb:Q96JC1	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613311|imex:IM-25807-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	go:"GO:0005764"(lysosome)	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:F6C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:eBszsEkwjfvL5OSgghL9UemUppw	false	green fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P06790	uniprotkb:Q8N1B4	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13613349|imex:IM-25807-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	go:"GO:0031982"(vesicle)	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:F7A|comment:"Ectopically expressed VPS52 distributed in vesicles (Figure 7A). When co-expressed with 16, 18 or 39 E2, a colocalization of VPS52 and E2 proteins could be observed (Figure 7A). In addition, VPS52 vesicles concentrated in a perinuclear region specifically in the presence of 16E2, which in turn massively redistributed in these vesicles."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:BHUsRR7luBDOKSTMVoIX6frmfcs	false	green fluorescent protein tag:?-?	mcherry fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q8N1B4	uniprotkb:P24830	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	intact:EBI-13615369	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13615384|imex:IM-25807-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0031982"(vesicle)	-	-	figure legend:F7A|comment:"Ectopically expressed VPS52 distributed in vesicles (Figure 7A). When co-expressed with 16, 18 or 39 E2, a colocalization of VPS52 and E2 proteins could be observed (Figure 7A). In addition, VPS52 vesicles concentrated in a perinuclear region specifically in the presence of 16E2, which in turn massively redistributed in these vesicles."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rigid:+r3h8PQLEVLgYLBMkpvXfIGCT2Q	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:Q8N1B4	uniprotkb:P03120	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	intact:EBI-1779322|uniprotkb:Q71BI4	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0428"(imaging technique)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-13615394|imex:IM-25807-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	go:"GO:0031982"(vesicle)|go:"GO:0048471"(perinuclear region of cytoplasm)	-	-	figure legend:F7A|comment:"Ectopically expressed VPS52 distributed in vesicles (Figure 7A). When co-expressed with 16, 18 or 39 E2, a colocalization of VPS52 and E2 proteins could be observed (Figure 7A). In addition, VPS52 vesicles concentrated in a perinuclear region specifically in the presence of 16E2, which in turn massively redistributed in these vesicles."|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hacat)|taxid:9606(Homo sapiens immortalised keratinocytes)	-	2017/01/19	2017/01/20	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rigid:0Pi7HsEx8CWRFPx05NNRov0GZ9U	false	mcherry fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)
uniprotkb:P06921	uniprotkb:Q07021	intact:EBI-13613195	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046154|imex:IM-25807-12|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:V8cWLhn/8p4IQynnPKXxwkQyxlg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q13813	intact:EBI-13613195	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046149|imex:IM-25807-11|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:EjBfNc+QmO7byiT55funNPsYmbw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q07955	intact:EBI-13613195	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046164|imex:IM-25807-14|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:DF9+JvuRG5++GapUDLDVfafnxHg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P30101	intact:EBI-13613195	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046169|imex:IM-25807-15|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	rigid:jE2X63YrOczSEYdTA3xMRvWTYw0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96T23	intact:EBI-13613195	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046174|imex:IM-25807-16|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:3TmbdfsgOTRIkQWqTmerLrz6hqU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9BXK5	intact:EBI-13613195	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046179|imex:IM-25807-17|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:xU859TVN5/P5Qc+SVDuCc1Ye2jQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q13227	intact:EBI-13613195	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046184|imex:IM-25807-18|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:Oe3mdti8GW0S4212K4U8OCOcJuo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P15514	intact:EBI-13613195	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046189|imex:IM-25807-19|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rigid:MIbbJIPJDjp0/C+a357hf0ZGy5A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q07021	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046194|imex:IM-25807-20|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:cjpBBBNiC8qE+sW/deHvLiIkM+U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P11021	intact:EBI-13612615	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046199|imex:IM-25807-21|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:bxMqh76dnUuPOBRHi0Snaaemrkk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8N2W9	intact:EBI-13612615	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046204|imex:IM-25807-22|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:N51GpAsrYEM1vU9Hl1yBE5lfCWE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9BXK5	intact:EBI-13612615	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046209|imex:IM-25807-23|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:HzHYqeV5edbNdIRZpd9i28AFPd8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9NRL2	intact:EBI-13612615	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046214|imex:IM-25807-24|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:vxUmA5kXEJm/9LQaUDbYHcgcbDU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96T23	intact:EBI-13612615	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046219|imex:IM-25807-25|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:epYtdURYh1UrU3iiijkSv1LP3XY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P51523	intact:EBI-13612615	intact:EBI-2849074|uniprotkb:Q9UC18|uniprotkb:Q86XU8|uniprotkb:Q3ZCV9|uniprotkb:Q9NNX7|uniprotkb:Q9UC17|uniprotkb:B2RAK5|uniprotkb:Q5D057|uniprotkb:D3DXJ1|ensembl:ENSP00000331465|ensembl:ENSP00000376133|ensembl:ENSP00000445549	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:znf84_human(display_long)|uniprotkb:ZNF84(gene name)|psi-mi:ZNF84(display_short)|uniprotkb:Zinc finger protein HPF2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046224|imex:IM-25807-26|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_011533134.1|refseq:NP_001276900.1|refseq:NP_001276901.1|refseq:NP_001120844.1|refseq:NP_003419.3|refseq:XP_005266242.1|refseq:XP_005266243.1|ensembl:ENST00000327668(transcript)|ensembl:ENST00000392319(transcript)|ensembl:ENST00000539354(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|ensembl:ENSG00000198040(gene)	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:zsEc/0um2BHfMbCHJ7GFoH9Qwfo9606	rigid:CssWXYhPcko6FPFn2620Cccrptw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q5VT06	intact:EBI-13612615	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046229|imex:IM-25807-27|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:PK1THyAm0lxiWS7Fvm/wYu7uPMc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O14617	intact:EBI-13613195	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046159|imex:IM-25807-13|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	rigid:xQoM94WPPctjkWWGolJ95nx7Mt0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9NYY3	intact:EBI-15989725	intact:EBI-721354|uniprotkb:O60679|uniprotkb:Q96CV7|uniprotkb:Q9UE61|ensembl:ENSP00000274289	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:plk2_human(display_long)|uniprotkb:Polo-like kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SNK(gene name synonym)|uniprotkb:Serum-inducible kinase(gene name synonym)|uniprotkb:PLK2(gene name)|psi-mi:PLK2(display_short)|uniprotkb:SNK(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046369|imex:IM-25807-55|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-48943N|refseq:NP_006613.2|refseq:NP_001239155.1|ensembl:ENSG00000145632(gene)|ensembl:ENST00000274289(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|interpro:IPR042825|rcsb pdb:4I5M|rcsb pdb:4I5P|rcsb pdb:4I6B|rcsb pdb:4I6F|rcsb pdb:4I6H|rcsb pdb:4RS6|rcsb pdb:4XB0|reactome:R-HSA-6804115|reactome:R-HSA-9662834	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:pjEqMnSG5E6daeauZylX38gmiS09606	rigid:1f7PRvdHlwTSEb3zsIVWGK+Bu78	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O43791	intact:EBI-15989725	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046364|imex:IM-25807-54|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:p5NN6EXztTcINBQpR2yr38yU3qw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9UBD5	intact:EBI-15989725	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046359|imex:IM-25807-53|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rigid:33+ztn02YRY3uktJqs03Bjh9Wx8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9UHY1	intact:EBI-15989725	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046354|imex:IM-25807-52|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:zuva30OQ1LOGYVL2q4mhRWwIv6Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q13287	intact:EBI-15989725	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046349|imex:IM-25807-51|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:Lm+X8YkZ7Vtg7/C/m+chJaHMC/A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9P086	intact:EBI-15989725	intact:EBI-394704|uniprotkb:Q6NS89|ensembl:ENSP00000293777	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:med11_human(display_long)|uniprotkb:Mediator complex subunit 11(gene name synonym)|uniprotkb:MED11(gene name)|psi-mi:MED11(display_short)|uniprotkb:HSPC296(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046344|psi-mi:"MI:0471"|imex:IM-25807-50	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001291929.1|refseq:NP_001001683.1|ensembl:ENSG00000161920(gene)|ensembl:ENST00000293777(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019404|mint:Q9P086|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:y7SZi5hIo5aOatJSZi98Hqt082A9606	rigid:v2e4ExdP3CGG72T5YdmrvFlWATQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P22314	intact:EBI-15989725	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046339|psi-mi:"MI:0471"|imex:IM-25807-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:UA2hauByttHvahdMlJeYPqggd8Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P16144	intact:EBI-15989725	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046334|psi-mi:"MI:0471"|imex:IM-25807-48	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:au/BEUuG607t9bn2BWAxE19XdQ8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P16144	intact:EBI-15989619	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046329|psi-mi:"MI:0471"|imex:IM-25807-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:yxe6kzfxZ3AMP3OqD3YR3RWNKVw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:O94986	intact:EBI-15989619	intact:EBI-311012|uniprotkb:Q6NTA0|uniprotkb:Q17RV1|ensembl:ENSP00000370337|uniprotkb:E7ER66|intact:EBI-11051708	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce152_human(display_long)|uniprotkb:CEP152(gene name)|psi-mi:CEP152(display_short)|uniprotkb:KIAA0912(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046324|psi-mi:"MI:0471"|imex:IM-25807-46	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001181927.1|refseq:NP_055800.2|ensembl:ENSG00000103995(gene)|ensembl:ENST00000380950(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030030"(cell projection organization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0098535"(de novo centriole assembly involved in multi-ciliated epithelial cell differentiation)|go:"GO:0098536"(deuterosome)|interpro:IPR029598|rcsb pdb:4N7V|rcsb pdb:6CSU|rcsb pdb:6CSV|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:XP_006720500.1|dip:DIP-31701N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:DRsdcItdRrPGvH+XWso5HudGwxw9606	rigid:Gg8LNOOE20ZxqUPu0VfzScSkr6M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q9NYF3	intact:EBI-15989619	intact:EBI-1644252|uniprotkb:D3DQB9|uniprotkb:B2RDJ5|ensembl:ENSP00000239906|ensembl:ENSP00000403705	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fa53c_human(display_long)|uniprotkb:FAM53C(gene name)|psi-mi:FAM53C(display_short)|uniprotkb:C5orf6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046319|psi-mi:"MI:0471"|imex:IM-25807-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001129119.1|refseq:NP_057689.1|ensembl:ENSG00000120709(gene)|ensembl:ENST00000239906(transcript)|ensembl:ENST00000434981(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006606"(protein import into nucleus)|interpro:IPR029356	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:DOnDTyw+f+NYBQnR1iWWlajGf9I9606	rigid:8ulgs/J2U5tUoQYtkA3iN1SpkOk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P53365	intact:EBI-15989619	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046314|psi-mi:"MI:0471"|imex:IM-25807-44	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:DhsDjjvgW8Rj1l/m1X7SHCGui+U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q13950	intact:EBI-15989619	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046309|psi-mi:"MI:0471"|imex:IM-25807-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:sqaWZ0m/yZn7MVXN8Tp43Kruazk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q13123	intact:EBI-15989619	intact:EBI-713456|uniprotkb:Q6IPD8|ensembl:ENSP00000396301	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:red_human(display_long)|uniprotkb:Protein RER(gene name synonym)|uniprotkb:IK factor(gene name synonym)|uniprotkb:Cytokine IK(gene name synonym)|uniprotkb:IK(gene name)|psi-mi:IK(display_short)|uniprotkb:RED(gene name synonym)|uniprotkb:RER(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046304|psi-mi:"MI:0471"|imex:IM-25807-42	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000113141(gene)|ensembl:ENST00000417647(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0016607"(nuclear speck)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0042802"(identical protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR012492(RED-like, C-terminal)|interpro:IPR012916(RED-like, N-terminal)|interpro:IPR039896|mint:Q13123|rcsb pdb:5O9Z|rcsb pdb:6Q8I|refseq:NP_006074.2	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:EBUQl+Gj0ozHP85Uh4xc9q2Vr6Y9606	rigid:YQnBBdxMGQGqx8Py0UGlVDW4cfg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P12814	intact:EBI-15989619	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046299|psi-mi:"MI:0471"|imex:IM-25807-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:Uqx02pbknF5w7SXDOjg3MtpwK5U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86XZ4	uniprotkb:P36791	intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8	intact:EBI-15989619	psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name)	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046294|psi-mi:"MI:0471"|imex:IM-25807-40	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rigid:j2k/tQJpCp8w++IY8gcaK0dr80M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:O95251	intact:EBI-15989619	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046289|psi-mi:"MI:0471"|imex:IM-25807-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:/pNo64ZQjq/ptRRg9H58nOgKI6U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q66K74	intact:EBI-15989619	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046284|psi-mi:"MI:0471"|imex:IM-25807-38	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:24zvnejFOX0Ck9SVECsm10hIuuM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P50616	intact:EBI-15989619	intact:EBI-723281|uniprotkb:Q4KMQ0|intact:EBI-28983166|ensembl:ENSP00000268957|ensembl:ENSP00000427695|uniprotkb:B2R9T0|uniprotkb:D3DTY3	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tob1_human(display_long)|uniprotkb:Transducer of erbB-2 1(gene name synonym)|uniprotkb:TOB1(gene name)|psi-mi:TOB1(display_short)|uniprotkb:TOB(gene name synonym)|uniprotkb:TROB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046279|psi-mi:"MI:0471"|imex:IM-25807-37	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005740.1|refseq:NP_001230806.1|refseq:NP_001230814.1|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:P50616|rcsb pdb:2D5R|rcsb pdb:2Z15|rcsb pdb:5CI8|rcsb pdb:5CI9|go:"GO:0045668"(negative regulation of osteoblast differentiation)|ensembl:ENSG00000141232(gene)|ensembl:ENST00000268957(transcript)|ensembl:ENST00000499247(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|ensembl:ENSP00000268957|ensembl:ENSP00000427695	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:kJ3wPXuioip9D7MDuFmxnXTkP9w9606	rigid:SBq80fuyXcKguLGEjp951XKvspI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P02751	intact:EBI-15989619	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046274|psi-mi:"MI:0471"|imex:IM-25807-36	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/10/18	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:x25oIN6X3EriY0B4xDZ0jAhrR/Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q9NY93	intact:EBI-15989619	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046269|psi-mi:"MI:0471"|imex:IM-25807-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:U0DLXxlQy35z20ZeKw8mC9UhZms	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q6ZN55	intact:EBI-15989619	intact:EBI-2818349|uniprotkb:Q6ZN10|uniprotkb:Q9H6N0|uniprotkb:Q8NCE3|uniprotkb:Q6IPE0|uniprotkb:Q7L5Z5|intact:EBI-28978517|ensembl:ENSP00000469029|ensembl:ENSP00000351939	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zn574_human(display_long)|uniprotkb:ZNF574(gene name)|psi-mi:ZNF574(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046264|psi-mi:"MI:0471"|imex:IM-25807-34	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:XP_011525530.1|refseq:XP_011525531.1|refseq:XP_011525532.1|refseq:NP_073589.4|ensembl:ENSP00000351939|ensembl:ENSP00000469029|refseq:XP_005259216.1|refseq:NP_001317448.1|ensembl:ENST00000359044(transcript)|ensembl:ENST00000600245(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSG00000105732(gene)	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:Ntg8Cl91sPslQWwFJfCHYQ063IM9606	rigid:bV/yuP978TXsClgPAg0oAI+PQbo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q96KG9	intact:EBI-15989619	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046259|psi-mi:"MI:0471"|imex:IM-25807-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:6cuVREHwfLYujmCYfAXNET2mZJY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q14533	intact:EBI-15989619	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046254|psi-mi:"MI:0471"|imex:IM-25807-32	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:s5D3vTIa06Z2ra/U0p86n1Wj4yU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q9UJY5	intact:EBI-15989619	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046249|psi-mi:"MI:0471"|imex:IM-25807-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:BMBjH/l4X420N9VEidi4vY7aKzQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P06733	intact:EBI-15989619	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046244|imex:IM-25807-30|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:jNMAwXFFEi8uOUlEkCODgEdGqhY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8IWI9	intact:EBI-13612615	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046239|imex:IM-25807-29|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:xdYnhLL/1fczJ2rFkchelE/gHwc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O14617	intact:EBI-13612615	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046234|imex:IM-25807-28|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	rigid:ty8kavvcRsY6eqVVBUfTvcNgGAg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O14617	intact:EBI-15989725	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046374|imex:IM-25807-56|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	rigid:aP0TnzXiB4eLXjqazBzLEUgSWMk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q96QE5	intact:EBI-15989725	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046379|imex:IM-25807-57|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:lo1H8NlDn+JVvjiFAn6SPCQ9AgY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q99698	intact:EBI-15989725	intact:EBI-2830208|uniprotkb:Q5T2U9|uniprotkb:O43274|uniprotkb:Q96TD8|uniprotkb:Q96TD7|uniprotkb:Q9H133|uniprotkb:Q99709|ensembl:ENSP00000374443	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:lyst_human(display_long)|uniprotkb:LYST(gene name)|psi-mi:LYST(display_short)|uniprotkb:CHS(gene name synonym)|uniprotkb:CHS1(gene name synonym)|uniprotkb:Beige homolog(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046384|imex:IM-25807-58|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001288294.1|ensembl:ENSG00000143669(gene)|ensembl:ENST00000389793(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0007040"(lysosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032438"(melanosome organization)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043473"(pigmentation)|go:"GO:0051607"(defense response to virus)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019775|interpro:IPR023362|interpro:IPR030464|interpro:IPR036322|interpro:IPR036372|refseq:NP_000072.2	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:vO+yDuFmFJ9TEmQ7JeUpni4mguY9606	rigid:ZyYmXSgxSUt6aMGwjD2TBs5uoPY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q16236	intact:EBI-15989725	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046389|imex:IM-25807-59|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:Uoh1XLV8AAtGlWvYQdtBN1l0kD0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:Q77UU1	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-15989725	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046394|imex:IM-25807-60|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rigid:Y51EZRjnxv8snkslXT9eHqLUiCU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P30101	intact:EBI-15989725	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046399|imex:IM-25807-61|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	rigid:rgq7O5we9ew29yFRUZURGlkWYG8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6Z7	uniprotkb:Q77UU1	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	intact:EBI-15989725	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046404|psi-mi:"MI:0471"|imex:IM-25807-62	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rigid:t2B6oNybkXUT2kYuIz1aXrNTekI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O15305	intact:EBI-15989725	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046409|psi-mi:"MI:0471"|imex:IM-25807-63	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:xIGeZ2GSduHec4elbefTyr64kyc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q96QF0	intact:EBI-15989725	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046414|psi-mi:"MI:0471"|imex:IM-25807-64	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:MnaLEXVBci+ZfafIrxtcbUVUCmY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q13813	intact:EBI-15989725	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046419|psi-mi:"MI:0471"|imex:IM-25807-65	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:WdGl/3oQWqx7pEt4uLb+BhJRa6Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q8NAP3	intact:EBI-7010556|intact:MINT-95651	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046424|psi-mi:"MI:0471"|imex:IM-25807-66	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:aRUHHc1Mv1iJi28AaU9cR+Ort2M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9Y2S7	intact:EBI-7010556|intact:MINT-95651	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046429|psi-mi:"MI:0471"|imex:IM-25807-67	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:U9CdsJsTXSIQD7pIH6J+0iYcet0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O43791	intact:EBI-7010556|intact:MINT-95651	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046434|psi-mi:"MI:0471"|imex:IM-25807-68	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:APQr5ubeNt8+pzpqjO+5wddB6ys	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O15305	intact:EBI-7010556|intact:MINT-95651	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046439|psi-mi:"MI:0471"|imex:IM-25807-69	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:cN5HQ9xO//YbnmUmySS/gXCMHIE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P30101	intact:EBI-7010556|intact:MINT-95651	intact:EBI-979862|uniprotkb:Q13453|uniprotkb:Q14255|uniprotkb:Q8IYF8|uniprotkb:Q9UMU7|ensembl:ENSP00000300289	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia3_human(display_long)|uniprotkb:Disulfide isomerase ER-60(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:58 kDa microsomal protein(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 57(gene name synonym)|uniprotkb:58 kDa glucose-regulated protein(gene name synonym)|uniprotkb:PDIA3(gene name)|psi-mi:PDIA3(display_short)|uniprotkb:ERP60(gene name synonym)|uniprotkb:GRP58(gene name synonym)|uniprotkb:ERP57(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046444|psi-mi:"MI:0471"|imex:IM-25807-70	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	interpro:IPR036249|interpro:IPR041868|mint:P30101|rcsb pdb:2ALB|rcsb pdb:2DMM|rcsb pdb:2H8L|rcsb pdb:3F8U|rcsb pdb:6ENY|reactome:R-HSA-1236974|reactome:R-HSA-901042|reactome:R-HSA-983170|interpro:IPR017937|ensembl:ENSG00000167004(gene)|ensembl:ENST00000300289(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0015036"(disulfide oxidoreductase activity)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|refseq:NP_005304.3|dip:DIP-29132N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:N/XktiLWB/cPju9nCq6yeyXnO1Q9606	rigid:i56ARFVV9bELVTm/g/uTB+DerUM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O14617	intact:EBI-7010556|intact:MINT-95651	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046449|imex:IM-25807-71|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	rigid:x4+SQmA0V2G9VMDfDGm+y7rqj3A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q13813	intact:EBI-7010556|intact:MINT-95651	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046459|imex:IM-25807-73|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:iZEewXjU7kVIuJxxP0LWq1EhSrg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P22314	intact:EBI-7010556|intact:MINT-95651	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046454|imex:IM-25807-72|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:I5QT1ViFD8rwTpf8MdAlnJtruRU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9H5V8	intact:EBI-13615369	intact:EBI-1019736|uniprotkb:Q49UB4|uniprotkb:Q6NT71|uniprotkb:Q6U9Y2|uniprotkb:Q8WU91|uniprotkb:Q96QU7|uniprotkb:Q9H676|uniprotkb:Q9H8C2|ensembl:ENSP00000296129	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdcp1_human(display_long)|uniprotkb:CDCP1(gene name)|psi-mi:CDCP1(display_short)|uniprotkb:TRASK(gene name synonym)|uniprotkb:UNQ2486/PRO5773(orf name)|uniprotkb:Transmembrane and associated with src kinases(gene name synonym)|uniprotkb:Membrane glycoprotein gp140(gene name synonym)|uniprotkb:Subtractive immunization M plus HEp3-associated 135 kDa protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046644|imex:IM-25807-110|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_073753.3|refseq:NP_835488.1|dip:DIP-33861N|ensembl:ENSG00000163814(gene)|ensembl:ENST00000296129(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR035914|interpro:IPR038811	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:sAXK+WNzP2qtJ53Fu6+cuehNA289606	rigid:KoRpOEfOpIDj2oQy+eHFsoECURQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P62158	intact:EBI-13615369	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046639|imex:IM-25807-109|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:ihJiswXvNNbC/b+NgLnPvm5ukjQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q07817	intact:EBI-13615369	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046634|imex:IM-25807-108|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:GPtrGoRPYDmwucXa/rcE0kaNEu4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q96GD4	intact:EBI-13615369	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046629|imex:IM-25807-107|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	rigid:OiyFwtCSWMLna8W+31lCB8BeQGU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P02538	intact:EBI-13615369	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046624|imex:IM-25807-106|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:s6JesZnvpHtweYa92NdbYUJe0so	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q92905	intact:EBI-13615369	intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046619|imex:IM-25807-105|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606	rigid:cbmTKs7DyXUSFynnVRRIt4vfArY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8N2W9	intact:EBI-13615369	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046614|imex:IM-25807-104|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:9dax+Lbz/YqZX0f9OnPECbjCh18	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q13263	intact:EBI-13613158	intact:EBI-78139|uniprotkb:O00677|ensembl:ENSP00000253024|uniprotkb:Q7Z632|uniprotkb:Q93040|uniprotkb:Q96IM1	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tif1b_human(display_long)|uniprotkb:TRIM28(gene name)|psi-mi:TRIM28(display_short)|uniprotkb:KAP1(gene name synonym)|uniprotkb:RNF96(gene name synonym)|uniprotkb:TIF1B(gene name synonym)|uniprotkb:Tripartite motif-containing protein 28(gene name synonym)|uniprotkb:Nuclear corepressor KAP-1(gene name synonym)|uniprotkb:KRAB-associated protein 1(gene name synonym)|uniprotkb:KRAB-interacting protein 1(gene name synonym)|uniprotkb:RING finger protein 96(gene name synonym)|uniprotkb:E3 SUMO-protein ligase TRIM28(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TIF1-beta(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046609|imex:IM-25807-103|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000130726(gene)|ensembl:ENST00000253024(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007566"(embryo implantation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035851"(Krueppel-associated box domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0060028"(convergent extension involved in axis elongation)|go:"GO:0060669"(embryonic placenta morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6QAJ|rcsb pdb:6QU1|reactome:R-HSA-212436|reactome:R-HSA-3899300|reactome:R-HSA-9609690|go:"GO:1901536"(negative regulation of DNA demethylation)|go:"GO:1902187"|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000653"(regulation of genetic imprinting)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001487(Bromodomain)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036427|interpro:IPR037373|interpro:IPR042713|mint:Q13263|rcsb pdb:1FP0|rcsb pdb:2RO1|rcsb pdb:2YVR|rcsb pdb:6H3A|rcsb pdb:6I9H|refseq:NP_005753.1|dip:DIP-30891N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:/yXCDGKUyyYnArOLyfzx6uPR9QY9606	rigid:fWsEIYP+AZC5BU3pNlA6taaSivQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P04632	intact:EBI-13613158	intact:EBI-711828|uniprotkb:Q8WTX3|uniprotkb:Q96EW0|uniprotkb:A8K0P1|ensembl:ENSP00000246533|ensembl:ENSP00000464849	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cpns1_human(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:CAPNS1(gene name)|psi-mi:CAPNS1(display_short)|uniprotkb:CAPN4(gene name synonym)|uniprotkb:CAPNS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046604|imex:IM-25807-102|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000126247(gene)|ensembl:ENST00000246533(transcript)|ensembl:ENST00000588815(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|mint:P04632|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:4PHJ|rcsb pdb:4PHK|rcsb pdb:4PHM|rcsb pdb:4WQ2|rcsb pdb:4WQ3|rcsb pdb:5D69|rcsb pdb:6QLB|reactome:R-HSA-1474228|reactome:R-HSA-6809371|reactome:R-HSA-8862803|refseq:NP_001003962.1|refseq:NP_001740.1|refseq:NP_001289561.1|refseq:NP_001289562.1|refseq:XP_005259352.1|refseq:XP_005259353.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:siQugDvaWq0YjOr8qOCf0BsRRKs9606	rigid:B7z5fEzFmhBxun8jTIWX3LA4Kxw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q15631	intact:EBI-13613158	intact:EBI-1044160|uniprotkb:Q5U0K7|ensembl:ENSP00000374332|uniprotkb:B7Z3X8	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tsn_human(display_long)|uniprotkb:TSN(gene name)|psi-mi:TSN(display_short)|uniprotkb:Component 3 of promoter of RISC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046599|imex:IM-25807-101|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006310"(DNA recombination)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR002848(Translin)|interpro:IPR033956|interpro:IPR036081|mint:Q15631|rcsb pdb:1J1J|rcsb pdb:3PJA|interpro:IPR016068(Translin, N-terminal)|rcsb pdb:3QB5|rcsb pdb:4WYV|reactome:R-HSA-426486|interpro:IPR016069(Translin, C-terminal)|ensembl:ENSG00000211460(gene)|ensembl:ENST00000389682(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_004613.1|refseq:NP_001248330.1|dip:DIP-42216N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:Gv/cF7n6u7XUAQMK/YVsJ0yG93I9606	rigid:AJg+VY5RhwUnPtyo4MNjQ+9sxic	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9HB07	intact:EBI-13613158	intact:EBI-709754|ensembl:ENSP00000267103|uniprotkb:Q86UA3|intact:EBI-10258793	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:myg1_human(display_long)|uniprotkb:MYG1(gene name)|psi-mi:MYG1(display_short)|uniprotkb:C12orf10(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046594|psi-mi:"MI:0471"|imex:IM-25807-100	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000139637(gene)|ensembl:ENST00000267103(transcript)|go:"GO:0004518"(nuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0035641"(locomotory exploration behavior)|interpro:IPR003226(Metal-dependent protein hydrolase)|mint:Q9HB07|refseq:NP_067653.3	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2020/06/18	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:k6ea0h/OMRODp3PQjed6sdxw44I9606	rigid:lPKlVk64mu+e1bs7GC1MHStLqzs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O14735	intact:EBI-13613158	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046589|psi-mi:"MI:0471"|imex:IM-25807-99	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:NHdogboPCRuDMHrcJnMHVolNblk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q96BR6	intact:EBI-13613158	intact:EBI-12006574|ensembl:ENSP00000342818|uniprotkb:B3KP94|uniprotkb:Q5VT39|uniprotkb:Q9H9Q6	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zn669_human(display_long)|uniprotkb:ZNF669(gene name)|psi-mi:ZNF669(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046584|psi-mi:"MI:0471"|imex:IM-25807-98	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000188295(gene)|ensembl:ENST00000343381(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001136044.1|refseq:NP_079080.2	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:Z3QU2mbmgGdKBQ8UP4q4EfafeMc9606	rigid:o9ujO61A3gNviKcqtJ+nIdvS4yc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9NZV6	intact:EBI-13613158	intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046579|psi-mi:"MI:0471"|imex:IM-25807-97	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:DR4z/+yUfitTjUy4b722w3qyTk89606	rigid:N3+cf4dPrXEDMmvGxE0wtjLhYlA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8IWX8	intact:EBI-13613158	intact:EBI-2555370|uniprotkb:O00302|uniprotkb:Q99492|uniprotkb:Q4G0Y5|uniprotkb:Q8WU30|ensembl:ENSP00000439856	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cherp_human(display_long)|uniprotkb:DAN26(gene name synonym)|uniprotkb:SCAF6(gene name synonym)|uniprotkb:SR-related CTD-associated factor 6(gene name synonym)|uniprotkb:ERPROT 213-21(gene name synonym)|uniprotkb:CHERP(gene name)|psi-mi:CHERP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046574|psi-mi:"MI:0471"|imex:IM-25807-96	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006378.3|ensembl:ENSG00000085872(gene)|ensembl:ENST00000546361(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000467(D111/G-patch)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035967|interpro:IPR039037|reactome:R-HSA-72163	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:Snifq3RgcsxZ8r9MCExHeb242Ss9606	rigid:Ry5gvam4EhVxsE+s/6BGtGMNXfI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q92905	intact:EBI-13613158	intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046569|psi-mi:"MI:0471"|imex:IM-25807-95	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606	rigid:nliYxgBRb2o9Vu6Xm70gfYLdTqo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P22314	intact:EBI-13613158	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046564|psi-mi:"MI:0471"|imex:IM-25807-94	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:gS/pWXjXOcd/Jrje1XvyFHH2j/w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P09496	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046559|psi-mi:"MI:0471"|imex:IM-25807-93	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rigid:JUo+vEosi1/R5EUDm0RhVhKJW4o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q13813	intact:EBI-7010629|intact:MINT-95532	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046554|psi-mi:"MI:0471"|imex:IM-25807-92	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:4lvIMUr6WQVOij5yf2YhGK3AVec	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O94842	intact:EBI-7010629|intact:MINT-95532	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046549|psi-mi:"MI:0471"|imex:IM-25807-91	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:e+R+Hn036B3RP4PDtiB6Dwyc+D0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8IWI9	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046544|psi-mi:"MI:0471"|imex:IM-25807-90	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:30Aow4i1ageXYMDSn5WxX9cillI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9UHB9	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046539|psi-mi:"MI:0471"|imex:IM-25807-89	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606	rigid:or/WoafDfonFfhF4Urvfa8w10xw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q92905	intact:EBI-7010629|intact:MINT-95532	intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046534|psi-mi:"MI:0471"|imex:IM-25807-88	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606	rigid:FirWccWgLZhmjpkhArLPWNWuZTo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8N2W9	intact:EBI-7010629|intact:MINT-95532	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046529|psi-mi:"MI:0471"|imex:IM-25807-87	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:czG6iXYTuiRClluhj+CGYObKy6c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P04632	intact:EBI-7010629|intact:MINT-95532	intact:EBI-711828|uniprotkb:Q8WTX3|uniprotkb:Q96EW0|uniprotkb:A8K0P1|ensembl:ENSP00000246533|ensembl:ENSP00000464849	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cpns1_human(display_long)|uniprotkb:Calcium-dependent protease small subunit 1(gene name synonym)|uniprotkb:Calcium-dependent protease small subunit(gene name synonym)|uniprotkb:Calpain regulatory subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase small subunit(gene name synonym)|uniprotkb:CAPNS1(gene name)|psi-mi:CAPNS1(display_short)|uniprotkb:CAPN4(gene name synonym)|uniprotkb:CAPNS(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046524|psi-mi:"MI:0471"|imex:IM-25807-86	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000126247(gene)|ensembl:ENST00000246533(transcript)|ensembl:ENST00000588815(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029642|mint:P04632|rcsb pdb:1KFU|rcsb pdb:1KFX|rcsb pdb:4PHJ|rcsb pdb:4PHK|rcsb pdb:4PHM|rcsb pdb:4WQ2|rcsb pdb:4WQ3|rcsb pdb:5D69|rcsb pdb:6QLB|reactome:R-HSA-1474228|reactome:R-HSA-6809371|reactome:R-HSA-8862803|refseq:NP_001003962.1|refseq:NP_001740.1|refseq:NP_001289561.1|refseq:NP_001289562.1|refseq:XP_005259352.1|refseq:XP_005259353.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:siQugDvaWq0YjOr8qOCf0BsRRKs9606	rigid:gvn4R+3fBsfyJ4IxN0ncmBH24I0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q07021	intact:EBI-7010629|intact:MINT-95532	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046519|psi-mi:"MI:0471"|imex:IM-25807-85	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:WbO5LhFc/50v+0C7sBCQInX/ies	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q15910	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-530054|uniprotkb:Q15755|uniprotkb:Q92857|uniprotkb:B2RAQ1|uniprotkb:B3KS30|uniprotkb:B7Z1D6|uniprotkb:B7Z7L6|uniprotkb:Q96FI6|intact:EBI-746496|ensembl:ENSP00000419711|uniprotkb:Q75MG3	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ezh2_human(display_long)|uniprotkb:KMT6(gene name synonym)|uniprotkb:Enhancer of zeste homolog 2(gene name synonym)|uniprotkb:ENX-1(gene name synonym)|uniprotkb:Lysine N-methyltransferase 6(gene name synonym)|uniprotkb:EZH2(gene name)|psi-mi:EZH2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046514|psi-mi:"MI:0471"|imex:IM-25807-84	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:XP_011514186.1|refseq:NP_001190176.1|refseq:NP_001190177.1|refseq:NP_001190178.1|refseq:NP_004447.2|refseq:NP_694543.1|go:"GO:0051154"(negative regulation of striated muscle cell differentiation)|go:"GO:0051932"(synaptic transmission, GABAergic)|ensembl:ENSG00000106462(gene)|ensembl:ENST00000460911(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0006348"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0021695"(cerebellar cortex development)|go:"GO:0021766"(hippocampus development)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0036333"(hepatocyte homeostasis)|go:"GO:0042054"(histone methyltransferase activity)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045120"(pronucleus)|go:"GO:0045202"(synapse)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048468"(cell development)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001214(SET)|interpro:IPR021654|interpro:IPR026489|interpro:IPR033467|interpro:IPR041343|interpro:IPR041355|interpro:IPR044439|mint:Q15910|rcsb pdb:2C6V|rcsb pdb:4MI0|rcsb pdb:4MI5|rcsb pdb:5GSA|rcsb pdb:5H14|rcsb pdb:5H15|rcsb pdb:5H17|rcsb pdb:5H19|rcsb pdb:5H24|rcsb pdb:5H25|rcsb pdb:5HYN|rcsb pdb:5IJ7|rcsb pdb:5IJ8|rcsb pdb:5LS6|rcsb pdb:5U5T|rcsb pdb:5U62|rcsb pdb:5WG6|rcsb pdb:5WUK|rcsb pdb:6C23|rcsb pdb:6C24|rcsb pdb:6P5L|rcsb pdb:6U4Y|rcsb pdb:6WKR|rcsb pdb:7AT8|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214841|reactome:R-HSA-5617472|reactome:R-HSA-8943724|reactome:R-HSA-8953750|reactome:R-HSA-9609690|go:"GO:0070734"(histone H3-K27 methylation)|reactome:R-HSA-9710421|go:"GO:0048511"(rhythmic process)|dip:DIP-34002N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:ZjwjEGDmMsyQ/33rYN7PimxvcUk9606	rigid:bikW9TH8f15LoihBb2pMukGpDHk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9NXF1	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2371062|uniprotkb:Q5T722|uniprotkb:Q5T723|uniprotkb:Q8NCN8|uniprotkb:Q8TDY0|uniprotkb:B4DYV2|ensembl:ENSP00000364037	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tex10_human(display_long)|uniprotkb:TEX10(gene name)|psi-mi:TEX10(display_short)|uniprotkb:L18(orf name)|uniprotkb:Nbla10363(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046509|psi-mi:"MI:0471"|imex:IM-25807-83	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_060216.2|refseq:NP_001155056.1|ensembl:ENSG00000136891(gene)|ensembl:ENST00000374902(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0071339"(MLL1 complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024679|interpro:IPR037947|mint:Q9NXF1|reactome:R-HSA-6791226	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:cQcRo1eExRkr/an7wvBN8Ttyatc9606	rigid:h9ygB1+9z0nUAF9j8LY7wPHkmVo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q13813	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046504|psi-mi:"MI:0471"|imex:IM-25807-82	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:bbhDLLLfvMEKpztKoZ65gO2M6tI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78383	uniprotkb:P03120	intact:EBI-12147661|ensembl:ENSP00000240333|uniprotkb:B4DEC4|uniprotkb:J3KQV4|uniprotkb:Q96EW7	intact:EBI-1779322|uniprotkb:Q71BI4	psi-mi:s35b1_human(display_long)|uniprotkb:SLC35B1(gene name)|psi-mi:SLC35B1(display_short)|uniprotkb:UDP-galactose transporter-related protein 1(gene name synonym)|uniprotkb:UGTREL1(gene name synonym)	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046499|imex:IM-25807-81|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000121073(gene)|ensembl:ENST00000240333(transcript)|go:"GO:0005459"(UDP-galactose transmembrane transporter activity)|go:"GO:0005460"(UDP-glucose transmembrane transporter activity)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0072334"(UDP-galactose transmembrane transport)|interpro:IPR013657(UAA transporter)|mint:P78383|refseq:NP_005818.2	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hE+cX4YN0VtGzzBUvbLKq4vLf4w9606	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rigid:oQuB52J1COrgd/8ODkQSqsIjadI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9BVW5	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046494|imex:IM-25807-80|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:hIsh0VPOQx0IXwcTbDzKoMVH9Jk	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q15365	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046489|imex:IM-25807-79|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:RHKVpdWi+CehTnqFG3DnXoTCHUU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q8WWY3	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046484|imex:IM-25807-78|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:I8SQFRZAHbUdMzykYE2Ku0d2XZQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q8N1B4	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046479|imex:IM-25807-77|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:0Pi7HsEx8CWRFPx05NNRov0GZ9U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O00308	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046474|imex:IM-25807-76|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:brjUdLcetNn2Y2KoaFOr6U1nXA0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P16144	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046469|imex:IM-25807-75|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:HFCqIYs1AmOZtjdtQpTukz5uocU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q8IWI9	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046464|imex:IM-25807-74|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:Yq0hda7iy8SBZowjVE+nrhP9NXc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8IZC6	intact:EBI-13615369	intact:EBI-2529384|uniprotkb:Q66K43|uniprotkb:Q96JF7|ensembl:ENSP00000348385	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cora1_human(display_long)|uniprotkb:COL27A1(gene name)|psi-mi:COL27A1(display_short)|uniprotkb:KIAA1870(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046676|psi-mi:"MI:0471"|imex:IM-25807-112	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000196739(gene)|ensembl:ENST00000356083(transcript)|go:"GO:0003431"(growth plate cartilage chondrocyte development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005583"(fibrillar collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-HSA-1650814|reactome:R-HSA-2022090|reactome:R-HSA-8874081|reactome:R-HSA-8948216|refseq:NP_116277.2	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:+Hwz0vac4YiN3eiJr0WxgHuQsiM9606	rigid:8I2LkNceWrawLA/eunfNtU5+uVg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O95471	intact:EBI-13615369	intact:EBI-740744|uniprotkb:Q6IPN3|uniprotkb:Q7Z4Y7|uniprotkb:Q9BVN0|uniprotkb:B2R9X7|uniprotkb:D3DTP0|ensembl:ENSP00000353475|ensembl:ENSP00000396638|ensembl:ENSP00000500298|ensembl:ENSP00000500460	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cld7_human(display_long)|uniprotkb:CLDN7(gene name)|psi-mi:CLDN7(display_short)|uniprotkb:CEPTRL2(gene name synonym)|uniprotkb:CPETRL2(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046671|psi-mi:"MI:0471"|imex:IM-25807-111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001171951.1|refseq:NP_001171952.1|refseq:NP_001298.3|ensembl:ENST00000360325(transcript)|ensembl:ENST00000397317(transcript)|ensembl:ENST00000672374(transcript)|ensembl:ENST00000672443(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007155"(cell adhesion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016338"(calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules)|go:"GO:0042802"(identical protein binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR003552(Claudin-7)|interpro:IPR004031(PMP-22/EMP/MP20/Claudin)|interpro:IPR006187(Claudin)|interpro:IPR017974|reactome:R-HSA-420029|ensembl:ENSG00000181885(gene)|ensembl:ENSG00000288292(gene)	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:fuMpDFEAVbThvzDfD0At7mjiQCE9606	rigid:nNyfHhPd5AbyuPZxvSGjACfrLwo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P11474	intact:EBI-13615369	intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046686|psi-mi:"MI:0471"|imex:IM-25807-114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606	rigid:OJb2CTyIlNrD1h+0Rp8PwR9AHzY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8NEZ5	intact:EBI-13615369	intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046691|psi-mi:"MI:0471"|imex:IM-25807-115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606	rigid:/f9bLw3LY369js1frYqRgnc96fA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P04792	intact:EBI-13615369	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046696|psi-mi:"MI:0471"|imex:IM-25807-116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:DiPzByjTQTXv0gLQeBQ+6CxjgU8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P80188	intact:EBI-13615369	intact:EBI-11911016|uniprotkb:A6NII8|uniprotkb:B4DWV4|uniprotkb:B7ZAA2|uniprotkb:P30150|uniprotkb:Q5SYV9|uniprotkb:Q5SYW0|uniprotkb:Q6FGL5|uniprotkb:Q92683|ensembl:ENSP00000277480|ensembl:ENSP00000362108	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ngal_human(display_long)|uniprotkb:Siderocalin(gene name synonym)|uniprotkb:LCN2(gene name)|psi-mi:LCN2(display_short)|uniprotkb:25 kDa alpha-2-microglobulin-related subunit of MMP-9(gene name synonym)|uniprotkb:HNL(gene name synonym)|uniprotkb:Lipocalin-2(gene name synonym)|uniprotkb:NGAL(gene name synonym)|uniprotkb:Oncogene 24p3(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046701|psi-mi:"MI:0471"|imex:IM-25807-117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005555.2|dip:DIP-29952N|ensembl:ENSG00000148346(gene)|ensembl:ENST00000277480(transcript)|ensembl:ENST00000373017(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0009635"(response to herbicide)|go:"GO:0009637"(response to blue light)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015891"(siderophore transport)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036094"(small molecule binding)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0042493"|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0097577"(sequestering of iron ion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903981"(enterobactin binding)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR003087(Neutrophil gelatinase-associated lipocalin)|interpro:IPR012674(Calycin)|interpro:IPR022272|mint:P80188|rcsb pdb:1DFV|rcsb pdb:1L6M|rcsb pdb:1NGL|rcsb pdb:1QQS|rcsb pdb:1X71|rcsb pdb:1X89|rcsb pdb:1X8U|rcsb pdb:3BY0|rcsb pdb:3CBC|rcsb pdb:3CMP|rcsb pdb:3DSZ|rcsb pdb:3DTQ|rcsb pdb:3FW4|rcsb pdb:3FW5|rcsb pdb:3HWD|rcsb pdb:3HWE|rcsb pdb:3HWF|rcsb pdb:3HWG|rcsb pdb:3I0A|rcsb pdb:3K3L|rcsb pdb:3PEC|rcsb pdb:3PED|rcsb pdb:3T1D|rcsb pdb:3TF6|rcsb pdb:3TZS|rcsb pdb:3U0D|rcsb pdb:4GH7|rcsb pdb:4IAW|rcsb pdb:4IAX|rcsb pdb:4K19|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4QAE|rcsb pdb:4ZFX|rcsb pdb:4ZHC|rcsb pdb:4ZHD|rcsb pdb:4ZHF|rcsb pdb:4ZHG|rcsb pdb:4ZHH|rcsb pdb:5JR8|rcsb pdb:5KHP|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|rcsb pdb:5KIC|rcsb pdb:5KID|rcsb pdb:5MHH|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:5NKN|rcsb pdb:6GQZ|rcsb pdb:6GR0|rcsb pdb:6QMU|rcsb pdb:6S8V|rcsb pdb:6SUA|rcsb pdb:6Z2C|rcsb pdb:6Z6Z|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-917937|rcsb pdb:6O5D	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:m5Q9A8rMP15tT8/Sdt2q/a3Xsr89606	rigid:uVoonOTSYYj9zz5GKHRRKESR4zQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02795	uniprotkb:P24830	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-13615369	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046706|psi-mi:"MI:0471"|imex:IM-25807-118	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rigid:y03roBbdtyuRQn7eA+CEyKaDl8E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P13667	intact:EBI-13615369	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046711|psi-mi:"MI:0471"|imex:IM-25807-119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:nd+GrJmcNAwIi8anIX08d1MoQqM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q14289	intact:EBI-13615369	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046716|psi-mi:"MI:0471"|imex:IM-25807-120	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:4yGua6spokL2l3nbPIEdEhSqeNA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q15223	intact:EBI-13615369	intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046721|psi-mi:"MI:0471"|imex:IM-25807-121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606	rigid:nXiVRc8x5fV9JSzaOOkUA6dERH0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P60602	intact:EBI-13615369	intact:EBI-11909831|ensembl:ENSP00000338293|ensembl:ENSP00000363190|ensembl:ENSP00000363191|ensembl:ENSP00000380561|uniprotkb:A7M872|uniprotkb:E1P5R9|uniprotkb:E9KL28|uniprotkb:Q3MHD5|uniprotkb:Q5QP16|uniprotkb:Q9CQ98|uniprotkb:Q9H1N2	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:romo1_human(display_long)|uniprotkb:ROMO1(gene name)|psi-mi:ROMO1(display_short)|uniprotkb:C20orf52(gene name synonym)|uniprotkb:Epididymis tissue protein Li 175(gene name synonym)|uniprotkb:Glyrichin(gene name synonym)|uniprotkb:Mitochondrial targeting GxxxG motif protein(gene name synonym)|uniprotkb:Protein MGR2 homolog(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046726|psi-mi:"MI:0471"|imex:IM-25807-122	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000125995(gene)|ensembl:ENST00000336695(transcript)|ensembl:ENST00000374077(transcript)|ensembl:ENST00000374078(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|ensembl:ENST00000397416(transcript)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0090399"(replicative senescence)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR018450|refseq:NP_542786.1|refseq:XP_016883167.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:uge1oh1J1tXmrxKIU27pM0z4P889606	rigid:BMAFDhjavyiScEj1kF5cGaBr12Y	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P04637	intact:EBI-13615369	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046731|psi-mi:"MI:0471"|imex:IM-25807-123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:1fjc6TuaaYIYmpEzHPEA8zYefCg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q14134	intact:EBI-13615369	intact:EBI-702370|uniprotkb:Q96AA9|uniprotkb:Q9BZY7|ensembl:ENSP00000343129	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tri29_human(display_long)|uniprotkb:Ataxia telangiectasia group D-associated protein(gene name synonym)|uniprotkb:TRIM29(gene name)|psi-mi:TRIM29(display_short)|uniprotkb:ATDC(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046736|psi-mi:"MI:0471"|imex:IM-25807-124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_036233.2|ensembl:ENSG00000137699(gene)|ensembl:ENST00000341846(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0002039"(p53 binding)|go:"GO:0005764"(lysosome)|go:"GO:0005912"(adherens junction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR000315(Zinc finger, B-box)|rcsb pdb:2CSV|reactome:R-HSA-877300	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:Sl9ZyD/8cbBpW722qTsDJ+YQqiE9606	rigid:MAInqe1bt3UJ5NFLFIE6betmJiw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8WWH5	intact:EBI-13615369	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046741|psi-mi:"MI:0471"|imex:IM-25807-125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:OLXj0y0jC5XOnACNMFQ7w5PilQo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P61086	intact:EBI-13615369	intact:EBI-473850|uniprotkb:A6NJC1|uniprotkb:O54806|uniprotkb:P27924|uniprotkb:Q16721|uniprotkb:Q9CVV9|uniprotkb:Q9Y2D3|uniprotkb:B2RDF8|uniprotkb:A8K5Y9|uniprotkb:C9JGP1|ensembl:ENSP00000261427	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ube2k_human(display_long)|uniprotkb:HIP2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-25 kDa(gene name synonym)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2(gene name synonym)|uniprotkb:UBE2K(gene name)|psi-mi:UBE2K(display_short)|uniprotkb:LIG(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme K(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046746|psi-mi:"MI:0471"|imex:IM-25807-126	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001104582.1|refseq:NP_001104583.1|refseq:NP_005330.1|dip:DIP-32524N|ensembl:ENSG00000078140(gene)|ensembl:ENST00000261427(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|interpro:IPR042599|rcsb pdb:1YLA|rcsb pdb:2O25|rcsb pdb:3E46|rcsb pdb:3F92|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:5DFL|rcsb pdb:6IF1|rcsb pdb:6JB6|rcsb pdb:6JB7|reactome:R-HSA-8866652|reactome:R-HSA-936440|reactome:R-HSA-983168	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:TTxSiXJ5fNdGUeuzYlPvDl8W7eg9606	rigid:okalGKdlpu39eMPhRgKWtmpK2xo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9NPD8	intact:EBI-13615369	intact:EBI-2130165|uniprotkb:Q2TU36|ensembl:ENSP00000494957	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ube2t_human(display_long)|uniprotkb:UBE2T(gene name)|psi-mi:UBE2T(display_short)|uniprotkb:Ubiquitin-protein ligase T(gene name synonym)|uniprotkb:Ubiquitin carrier protein T(gene name synonym)|uniprotkb:HSPC150(orf name)|uniprotkb:Cell proliferation-inducing gene 50 protein(gene name synonym)|uniprotkb:PIG50(orf name)|uniprotkb:E2 ubiquitin-conjugating enzyme T(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046751|psi-mi:"MI:0471"|imex:IM-25807-127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_054895.1|refseq:NP_001297255.1|dip:DIP-52740N|ensembl:ENSG00000077152(gene)|ensembl:ENST00000646651(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1YH2|rcsb pdb:4CCG|rcsb pdb:5NGZ|rcsb pdb:5OJJ|rcsb pdb:6R75|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-8866652	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:hKFqKCWzIhcGshB1ut+mTTSwxbQ9606	rigid:3RvmgNlPIXGYiMSPmAozZuiZblo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q96JC1	intact:EBI-13615369	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046756|psi-mi:"MI:0471"|imex:IM-25807-128	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:nVdUN27p1G5z5TitemPx8EruTf8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O14980	intact:EBI-13615369	intact:EBI-355867|uniprotkb:A6NL14|uniprotkb:A8K1K5|uniprotkb:Q63HP8|uniprotkb:Q68CP3|uniprotkb:Q99433|uniprotkb:D6W5E2|ensembl:ENSP00000384863|ensembl:ENSP00000385559|ensembl:ENSP00000385942|ensembl:ENSP00000503167|ensembl:ENSP00000503419|ensembl:ENSP00000503482|ensembl:ENSP00000503572|ensembl:ENSP00000503809|ensembl:ENSP00000504087|ensembl:ENSP00000504198|ensembl:ENSP00000504247|ensembl:ENSP00000504543|ensembl:ENSP00000504594|ensembl:ENSP00000504848	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:xpo1_human(display_long)|uniprotkb:CRM1(gene name synonym)|uniprotkb:XPO1(gene name)|psi-mi:XPO1(display_short)|uniprotkb:Chromosome region maintenance 1 protein homolog(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046761|psi-mi:"MI:0471"|imex:IM-25807-129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENST00000678182(transcript)|ensembl:ENST00000678790(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042493"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0051028"(mRNA transport)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR014877(Exportin 1, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040485|interpro:IPR041123|interpro:IPR041235|go:"GO:0031267"(small GTPase binding)|mint:O14980|rcsb pdb:1W9C|rcsb pdb:2L1L|rcsb pdb:3GB8|rcsb pdb:4BSM|rcsb pdb:4BSN|rcsb pdb:5DIS|rcsb pdb:6TVO|go:"GO:0031965"(nuclear membrane)|rcsb pdb:7B51|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-168333|reactome:R-HSA-2173788|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3769402|reactome:R-HSA-450520|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-68877|reactome:R-HSA-69273|reactome:R-HSA-9634638|reactome:R-HSA-9648025|reactome:R-HSA-9707616|refseq:NP_003391.1|refseq:XP_011531399.1|ensembl:ENSG00000082898(gene)|ensembl:ENST00000401558(transcript)|ensembl:ENST00000404992(transcript)|ensembl:ENST00000406957(transcript)|ensembl:ENST00000676553(transcript)|ensembl:ENST00000676667(transcript)|ensembl:ENST00000677150(transcript)|ensembl:ENST00000677239(transcript)|ensembl:ENST00000677417(transcript)|ensembl:ENST00000677813(transcript)|ensembl:ENST00000677814(transcript)|ensembl:ENST00000677928(transcript)|ensembl:ENST00000677933(transcript)|refseq:XP_006712157.1|dip:DIP-33678N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:wgxK39oV5wJ6mUuxM/jxqBtukEg9606	rigid:r7XkuEA6hdQFDeLILQPBqHG68zE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P11021	intact:EBI-13615369	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046766|psi-mi:"MI:0471"|imex:IM-25807-130	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:C/2cHoZ2QgxPcMovgSfSwumPvm4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P07858	intact:EBI-13615369	intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046681|psi-mi:"MI:0471"|imex:IM-25807-113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606	rigid:o7uskadYY/uSF6Db83m3IBZTcmE	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9BZF9	intact:EBI-13615369	intact:EBI-350510|uniprotkb:Q14DD3|uniprotkb:Q8N3B8|uniprotkb:Q9HCL1|uniprotkb:Q9NWC6|uniprotkb:G3XAG2|uniprotkb:Q96NH6|intact:EBI-10977773|ensembl:ENSP00000314556	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uaca_human(display_long)|uniprotkb:UACA(gene name)|psi-mi:UACA(display_short)|uniprotkb:KIAA1561(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046771|psi-mi:"MI:0471"|imex:IM-25807-131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001008225.1|refseq:NP_060473.2|dip:DIP-33117N|ensembl:ENSG00000137831(gene)|ensembl:ENST00000322954(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR030227|interpro:IPR036770|mint:Q9BZF9|reactome:R-HSA-9013407|reactome:R-HSA-9627069	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:F58VkGk2DBsUUrB+wgknUFZhJ+E9606	rigid:6oeCUP6MwYCIcv7gTKgT2QgK2TQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8IWI9	intact:EBI-13615369	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046776|psi-mi:"MI:0471"|imex:IM-25807-132	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:i7lsv+FBNQys6VtFX3Yxic9F9zM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q13813	intact:EBI-13615369	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046781|psi-mi:"MI:0471"|imex:IM-25807-133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:Cd/XN48i/Xz5ocEmt9IZkoVgGeI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9Y2S7	intact:EBI-15990239	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046786|psi-mi:"MI:0471"|imex:IM-25807-134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:6NKD2RO4V+6tjDFgxQV2wEe3NpY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9Y6X2	intact:EBI-15990239	intact:EBI-2803703|uniprotkb:Q9UFI3|intact:EBI-28970301|ensembl:ENSP00000376765	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias3_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 3(gene name synonym)|uniprotkb:PIAS3(gene name)|psi-mi:PIAS3(display_short)|uniprotkb:E3 SUMO-protein transferase PIAS3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046791|psi-mi:"MI:0471"|imex:IM-25807-135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000376765|ensembl:ENSG00000131788(gene)|ensembl:ENST00000393045(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009725"(response to hormone)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0045202"(synapse)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045838"(positive regulation of membrane potential)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:Q9Y6X2|rcsb pdb:4MVT|reactome:R-HSA-3232118|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5696395|go:"GO:0016925"(protein sumoylation)|refseq:NP_006090.2|dip:DIP-5969N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:uAxtGVgFcpm5yJL1rul8vVciHZA9606	rigid:azFh6N60XPgsHIB/UGErs5wstrM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q7L622	intact:EBI-15990239	intact:EBI-751757|uniprotkb:Q9BVR2|uniprotkb:Q9H9E9|uniprotkb:Q9NXC0|uniprotkb:Q9P2L3|ensembl:ENSP00000206595	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:g2e3_human(display_long)|uniprotkb:G2E3(gene name)|psi-mi:G2E3(display_short)|uniprotkb:KIAA1333(gene name synonym)|uniprotkb:G2/M phase-specific HECT-type E3 ubiquitin transferase(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046796|psi-mi:"MI:0471"|imex:IM-25807-136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_060239.2|refseq:NP_001295026.1|refseq:XP_011535227.1|ensembl:ENST00000206595(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000569(HECT)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR034732|interpro:IPR035983|ensembl:ENSG00000092140(gene)|interpro:IPR042012|interpro:IPR042013	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:o65kkSBJ3VjCjwrKhpT0vGpL9Z49606	rigid:J+HqH+hlgmAJBLbdbfmqCTe0+ak	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O14617	intact:EBI-15990239	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046801|psi-mi:"MI:0471"|imex:IM-25807-137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	rigid:bdccFKfWw6rGzQZ5I43K7hmTLPI	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q13813	intact:EBI-15990239	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046806|psi-mi:"MI:0471"|imex:IM-25807-138	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:VCYiqDV9PjiRrRqu7eshKZnMj7c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96BJ3	intact:EBI-15990239	intact:EBI-4401674|uniprotkb:A8K1F0|uniprotkb:Q49A81|uniprotkb:Q5JRA4|uniprotkb:Q658P1|uniprotkb:Q9H9E8|ensembl:ENSP00000339161	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aida_human(display_long)|uniprotkb:AIDA(gene name)|psi-mi:AIDA(display_short)|uniprotkb:C1orf80(gene name synonym)|uniprotkb:Axin interaction partner and dorsalization antagonist(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046811|psi-mi:"MI:0471"|imex:IM-25807-139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_073742.2|ensembl:ENSG00000186063(gene)|ensembl:ENST00000340020(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0016020"(membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048264"(determination of ventral identity)|interpro:IPR023421|interpro:IPR025939|interpro:IPR035892|interpro:IPR036818	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:Eo7oyV29ug5MrDH2coUbbW68pdc9606	rigid:0OPErmC4de+yvm86vhQDzPgD850	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O43791	intact:EBI-15990239	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046816|psi-mi:"MI:0471"|imex:IM-25807-140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:6mxt7yeEuXi+3LHMlWdMwjsFeg8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9Y2S7	intact:EBI-15990288	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046821|imex:IM-25807-141|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:+yBU8tAGVqhtoTgeBLbkeEz9Ypo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P02538	intact:EBI-15990288	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046826|imex:IM-25807-142|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:+XwyFcjqurW4BVv7aehOvEu4gnw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8NAP3	intact:EBI-15990288	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046831|imex:IM-25807-143|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:kqf0kwCDjtQlQ6eoRuE/T+WrzCA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P25787	intact:EBI-15990288	intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046836|imex:IM-25807-144|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606	rigid:dc8Fl6LliBqmQudkVjKmHn1tO+o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRH9	uniprotkb:P03118	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	intact:EBI-15990288	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046841|imex:IM-25807-145|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rigid:1Rgb0BtFFC1qwzfGEaAVCdOJySQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96BJ3	intact:EBI-15990288	intact:EBI-4401674|uniprotkb:A8K1F0|uniprotkb:Q49A81|uniprotkb:Q5JRA4|uniprotkb:Q658P1|uniprotkb:Q9H9E8|ensembl:ENSP00000339161	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aida_human(display_long)|uniprotkb:AIDA(gene name)|psi-mi:AIDA(display_short)|uniprotkb:C1orf80(gene name synonym)|uniprotkb:Axin interaction partner and dorsalization antagonist(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046846|imex:IM-25807-146|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_073742.2|ensembl:ENSG00000186063(gene)|ensembl:ENST00000340020(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0016020"(membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048264"(determination of ventral identity)|interpro:IPR023421|interpro:IPR025939|interpro:IPR035892|interpro:IPR036818	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:Eo7oyV29ug5MrDH2coUbbW68pdc9606	rigid:NGzRJ2lFNQ61ZUq79rDnzf64HxU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O75925	intact:EBI-15990288	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046851|imex:IM-25807-147|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rigid:pkfNEdM024UlUr6YG59MnZfO96o	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8N2W9	intact:EBI-15990288	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046856|imex:IM-25807-148|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:Z7VWntNEYTZZvbfO0M5naKLY9BA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O14617	intact:EBI-15990288	intact:EBI-1051639|uniprotkb:O00202|uniprotkb:O75262|uniprotkb:Q59HF5|uniprotkb:Q96G11|uniprotkb:Q9H3C6|ensembl:ENSP00000344055	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ap3d1_human(display_long)|uniprotkb:AP-3 complex subunit delta(gene name synonym)|uniprotkb:Delta-adaptin(gene name synonym)|uniprotkb:AP3D1(gene name)|psi-mi:AP3D1(display_short)|uniprotkb:PRO0039(orf name)|uniprotkb:Adaptor-related protein complex 3 subunit delta-1(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046861|imex:IM-25807-149|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003929.4|refseq:NP_001248755.1|ensembl:ENSG00000065000(gene)|ensembl:ENST00000345016(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0032438"(melanosome organization)|go:"GO:0035646"(endosome to melanosome transport)|go:"GO:0043195"(terminal bouton)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048499"(synaptic vesicle membrane organization)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098943"(neurotransmitter receptor transport, postsynaptic endosome to lysosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR010474(Bovine leukaemia virus receptor)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017105(Adaptor protein complex AP-3, delta subunit)|mint:O14617|rcsb pdb:4AFI|dip:DIP-46793N	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:vw6bWz07cMYuwATlyDgx14oXzKY9606	rigid:4FX5PJwJtqI+YDVyDAMHC0XXS4w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q07021	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046871|psi-mi:"MI:0471"|imex:IM-25807-151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/11	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:cjpBBBNiC8qE+sW/deHvLiIkM+U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IWI9	uniprotkb:P03118	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	intact:EBI-15990288	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0397"(two hybrid array)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046866|imex:IM-25807-150|psi-mi:"MI:0471"	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	-	-	figure legend:ST3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rigid://7l4Mx689B4wKbk8eeCQHiIWwU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q01130	intact:EBI-13613195	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047015|psi-mi:"MI:0471"|imex:IM-25807-163	author score:13.78	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	rigid:at6Eok0uKNEDspoObEm9YSe9n8U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96KG9	intact:EBI-13613195	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047039|psi-mi:"MI:0471"|imex:IM-25807-165	author score:14.50	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:6qXS+Inmidakw9EsidtCGsBS0yc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q99698	intact:EBI-13613195	intact:EBI-2830208|uniprotkb:Q5T2U9|uniprotkb:O43274|uniprotkb:Q96TD8|uniprotkb:Q96TD7|uniprotkb:Q9H133|uniprotkb:Q99709|ensembl:ENSP00000374443	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:lyst_human(display_long)|uniprotkb:LYST(gene name)|psi-mi:LYST(display_short)|uniprotkb:CHS(gene name synonym)|uniprotkb:CHS1(gene name synonym)|uniprotkb:Beige homolog(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047051|psi-mi:"MI:0471"|imex:IM-25807-166	author score:15.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001288294.1|ensembl:ENSG00000143669(gene)|ensembl:ENST00000389793(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0007040"(lysosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032438"(melanosome organization)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043473"(pigmentation)|go:"GO:0051607"(defense response to virus)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019775|interpro:IPR023362|interpro:IPR030464|interpro:IPR036322|interpro:IPR036372|refseq:NP_000072.2	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:vO+yDuFmFJ9TEmQ7JeUpni4mguY9606	rigid:co7DxbO1SAOFB3cEYTZ9MRLXaQY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P11021	intact:EBI-13613195	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047063|psi-mi:"MI:0471"|imex:IM-25807-167	author score:15.56	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:5Cc819isUA0xf+yy3gxz5gmbMYU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q5VT06	intact:EBI-13613195	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046883|psi-mi:"MI:0471"|imex:IM-25807-152	author score:10.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:cOQB9me70VbT8lRe7FprVKdDdA4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P56537	intact:EBI-13613195	intact:EBI-372243|uniprotkb:Q6IBN8|uniprotkb:Q96TD5|uniprotkb:B7ZBG9|ensembl:ENSP00000363559|ensembl:ENSP00000363574|ensembl:ENSP00000502429	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:if6_human(display_long)|uniprotkb:EIF6(gene name)|psi-mi:EIF6(display_short)|uniprotkb:ITGB4BP(gene name synonym)|uniprotkb:OK/SW-cl.27(orf name)|uniprotkb:B4 integrin interactor(gene name synonym)|uniprotkb:CAB(gene name synonym)|uniprotkb:"p27(BBP)"(gene name synonym)|uniprotkb:"B(2)GCN homolog"(gene name synonym)|uniprotkb:EIF3A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046895|psi-mi:"MI:0471"|imex:IM-25807-153	author score:10.53	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002203.1|refseq:NP_852131.1|refseq:NP_852133.1|refseq:NP_001254739.1|ensembl:ENSG00000242372(gene)|ensembl:ENST00000374436(transcript)|ensembl:ENST00000374450(transcript)|ensembl:ENST00000675032(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0032868"(response to insulin)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR002769(Translation initiation factor IF6)|mint:P56537|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:A0pOylQptNBlSiBKiZre7INejF49606	rigid:ObR7lXfAU/GsQcvdDewJdmiRNSk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P31274	intact:EBI-13613195	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046907|psi-mi:"MI:0471"|imex:IM-25807-154	author score:10.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:O22eAH40OdAO5aMc5/GhRlG5Y6k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9NRL2	intact:EBI-13613195	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046919|psi-mi:"MI:0471"|imex:IM-25807-155	author score:107.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:48XJ530+dhwSdkgGhjF6PgOf2NQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9UBD5	intact:EBI-13613195	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046931|psi-mi:"MI:0471"|imex:IM-25807-156	author score:11.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rigid:o9rBC3ZwXd0+yuKjvQtkSANUSx4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O15305	intact:EBI-13613195	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046943|psi-mi:"MI:0471"|imex:IM-25807-157	author score:11.18	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:Hn/mQ19mY93dAgExCei4ZLOtM7Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8WWY3	intact:EBI-13613195	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046955|psi-mi:"MI:0471"|imex:IM-25807-158	author score:11.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:mifapmlUs5bFOu7bZIzQQtWZ5nE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96JC1	intact:EBI-13613195	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046967|psi-mi:"MI:0471"|imex:IM-25807-159	author score:11.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:Tj6abnpq7RQdr6NveOdSEft92SM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q14289	intact:EBI-13613195	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046979|psi-mi:"MI:0471"|imex:IM-25807-160	author score:11.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:qxbEOu+777/T/kUU2BOjt9kpcvc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9Y570	intact:EBI-13613195	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16046991|psi-mi:"MI:0471"|imex:IM-25807-161	author score:12.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:bBN8YX6H9R7/s5g7L9KEzHEAzdM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9UHY1	intact:EBI-13613195	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047003|psi-mi:"MI:0471"|imex:IM-25807-162	author score:12.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:h9ifgewx6evJbI8Yc9FYHRNt7f0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9BVW5	intact:EBI-13613195	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047027|psi-mi:"MI:0471"|imex:IM-25807-164	author score:14.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:cJwUzhv7DaRRCxaDrece4oG/vqE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P02538	intact:EBI-13613195	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047303|imex:IM-25807-187|psi-mi:"MI:0471"	author score:29.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:anKgfNjYbmpiF5uFuGcawcBe1yE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P55209	intact:EBI-13613195	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047495|psi-mi:"MI:0471"|imex:IM-25807-203	author score:4.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:t7DYJhvuMJRhynKuPgg55hZENIA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O95251	intact:EBI-13613195	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047279|imex:IM-25807-185|psi-mi:"MI:0471"	author score:28.16	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:FJ5N5pYRzOiXzb/P+A1ozfXoOx4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P51523	intact:EBI-13613195	intact:EBI-2849074|uniprotkb:Q9UC18|uniprotkb:Q86XU8|uniprotkb:Q3ZCV9|uniprotkb:Q9NNX7|uniprotkb:Q9UC17|uniprotkb:B2RAK5|uniprotkb:Q5D057|uniprotkb:D3DXJ1|ensembl:ENSP00000331465|ensembl:ENSP00000376133|ensembl:ENSP00000445549	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:znf84_human(display_long)|uniprotkb:ZNF84(gene name)|psi-mi:ZNF84(display_short)|uniprotkb:Zinc finger protein HPF2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047267|imex:IM-25807-184|psi-mi:"MI:0471"	author score:27.72	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_011533134.1|refseq:NP_001276900.1|refseq:NP_001276901.1|refseq:NP_001120844.1|refseq:NP_003419.3|refseq:XP_005266242.1|refseq:XP_005266243.1|ensembl:ENST00000327668(transcript)|ensembl:ENST00000392319(transcript)|ensembl:ENST00000539354(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|ensembl:ENSG00000198040(gene)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:zsEc/0um2BHfMbCHJ7GFoH9Qwfo9606	rigid:3/IN0ZRbXT3w9U3VwZjYTp8QfBk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9NY93	intact:EBI-13613195	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047255|imex:IM-25807-183|psi-mi:"MI:0471"	author score:27.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:waPmu17zG4LIeyp9U009GnQAGUI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q14790	intact:EBI-13613195	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047243|imex:IM-25807-182|psi-mi:"MI:0471"	author score:27.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:yPfyLoJP9iC6OojxFjxQ7Eq35Wg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P04637	intact:EBI-13613195	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047231|imex:IM-25807-181|psi-mi:"MI:0471"	author score:26.43	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:ZTDIiJ4vFb8S02ZCvYs3qoOWcRE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q16236	intact:EBI-13613195	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047219|psi-mi:"MI:0471"|imex:IM-25807-180	author score:25.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:d79zrf0EUA/I1oGTvck6ihNJSYY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P53365	intact:EBI-13613195	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047207|psi-mi:"MI:0471"|imex:IM-25807-179	author score:22.45	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:UsXPuyLKOC+ARo48XFnDfSGMCFA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O95235	intact:EBI-13613195	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047075|psi-mi:"MI:0471"|imex:IM-25807-168	author score:15.87	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:mRF9Mr1220yyj1lU7coCFvOBJb8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q15365	intact:EBI-13613195	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047195|psi-mi:"MI:0471"|imex:IM-25807-178	author score:21.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:5MqIP/Iw/Hj6CFNh3UM9w4mup6Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O60885	intact:EBI-13613195	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047183|psi-mi:"MI:0471"|imex:IM-25807-177	author score:200.56	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:hmu7Pm2D2Uwz5Ltw8Ma8YhUty30	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8IWX8	intact:EBI-13613195	intact:EBI-2555370|uniprotkb:O00302|uniprotkb:Q99492|uniprotkb:Q4G0Y5|uniprotkb:Q8WU30|ensembl:ENSP00000439856	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cherp_human(display_long)|uniprotkb:DAN26(gene name synonym)|uniprotkb:SCAF6(gene name synonym)|uniprotkb:SR-related CTD-associated factor 6(gene name synonym)|uniprotkb:ERPROT 213-21(gene name synonym)|uniprotkb:CHERP(gene name)|psi-mi:CHERP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047171|psi-mi:"MI:0471"|imex:IM-25807-176	author score:20.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006378.3|ensembl:ENSG00000085872(gene)|ensembl:ENST00000546361(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000467(D111/G-patch)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035967|interpro:IPR039037|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:Snifq3RgcsxZ8r9MCExHeb242Ss9606	rigid:ltaWcb60e38j90nmAQsjvwoOh/w	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q86VP1	intact:EBI-13613195	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047159|psi-mi:"MI:0471"|imex:IM-25807-175	author score:18.36	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:DdeZCVUH/OW9dIlRPUUax4uc5rs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O00308	intact:EBI-13613195	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047147|psi-mi:"MI:0471"|imex:IM-25807-174	author score:18.21	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:az42zgQenMcUvKxRqPClshd3qFg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8WWH5	intact:EBI-13613195	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047135|psi-mi:"MI:0471"|imex:IM-25807-173	author score:17.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:fZqI+o1bG+VcmuB73zgSCJZKtJE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O14735	intact:EBI-13613195	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047123|psi-mi:"MI:0471"|imex:IM-25807-172	author score:17.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:mq6KAgZC+L6LFtRz1GDm/dG+Dcc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q07955	intact:EBI-13613195	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047111|psi-mi:"MI:0471"|imex:IM-25807-171	author score:167.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:DF9+JvuRG5++GapUDLDVfafnxHg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96QE5	intact:EBI-13613195	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047099|psi-mi:"MI:0471"|imex:IM-25807-170	author score:16.97	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:sFG6Epbr7P8UW2G8x3ITksJacRY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8NAP3	intact:EBI-13613195	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047087|psi-mi:"MI:0471"|imex:IM-25807-169	author score:16.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:197SQZKdmcAbDJkYzee4bWvMulo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q07817	intact:EBI-13613195	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047315|imex:IM-25807-188|psi-mi:"MI:0471"	author score:29.83	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:9ArcEhOImJxLIOqyC1N+jblomk0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9NYF3	intact:EBI-13613195	intact:EBI-1644252|uniprotkb:D3DQB9|uniprotkb:B2RDJ5|ensembl:ENSP00000239906|ensembl:ENSP00000403705	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fa53c_human(display_long)|uniprotkb:FAM53C(gene name)|psi-mi:FAM53C(display_short)|uniprotkb:C5orf6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047327|imex:IM-25807-189|psi-mi:"MI:0471"	author score:3.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001129119.1|refseq:NP_057689.1|ensembl:ENSG00000120709(gene)|ensembl:ENST00000239906(transcript)|ensembl:ENST00000434981(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006606"(protein import into nucleus)|interpro:IPR029356	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:DOnDTyw+f+NYBQnR1iWWlajGf9I9606	rigid:SumgbhMm8d3kfMxqTgb2wl0wUc8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9H5V8	intact:EBI-13613195	intact:EBI-1019736|uniprotkb:Q49UB4|uniprotkb:Q6NT71|uniprotkb:Q6U9Y2|uniprotkb:Q8WU91|uniprotkb:Q96QU7|uniprotkb:Q9H676|uniprotkb:Q9H8C2|ensembl:ENSP00000296129	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdcp1_human(display_long)|uniprotkb:CDCP1(gene name)|psi-mi:CDCP1(display_short)|uniprotkb:TRASK(gene name synonym)|uniprotkb:UNQ2486/PRO5773(orf name)|uniprotkb:Transmembrane and associated with src kinases(gene name synonym)|uniprotkb:Membrane glycoprotein gp140(gene name synonym)|uniprotkb:Subtractive immunization M plus HEp3-associated 135 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047339|imex:IM-25807-190|psi-mi:"MI:0471"	author score:3.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_073753.3|refseq:NP_835488.1|dip:DIP-33861N|ensembl:ENSG00000163814(gene)|ensembl:ENST00000296129(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR035914|interpro:IPR038811	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:sAXK+WNzP2qtJ53Fu6+cuehNA289606	rigid:ovr0iDrFEe2nKvFwgeRYGFBlK6U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P80188	intact:EBI-13613195	intact:EBI-11911016|uniprotkb:A6NII8|uniprotkb:B4DWV4|uniprotkb:B7ZAA2|uniprotkb:P30150|uniprotkb:Q5SYV9|uniprotkb:Q5SYW0|uniprotkb:Q6FGL5|uniprotkb:Q92683|ensembl:ENSP00000277480|ensembl:ENSP00000362108	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ngal_human(display_long)|uniprotkb:Siderocalin(gene name synonym)|uniprotkb:LCN2(gene name)|psi-mi:LCN2(display_short)|uniprotkb:25 kDa alpha-2-microglobulin-related subunit of MMP-9(gene name synonym)|uniprotkb:HNL(gene name synonym)|uniprotkb:Lipocalin-2(gene name synonym)|uniprotkb:NGAL(gene name synonym)|uniprotkb:Oncogene 24p3(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047351|psi-mi:"MI:0471"|imex:IM-25807-191	author score:3.81	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005555.2|dip:DIP-29952N|ensembl:ENSG00000148346(gene)|ensembl:ENST00000277480(transcript)|ensembl:ENST00000373017(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0009635"(response to herbicide)|go:"GO:0009637"(response to blue light)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015891"(siderophore transport)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036094"(small molecule binding)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0042493"|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0097577"(sequestering of iron ion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903981"(enterobactin binding)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR003087(Neutrophil gelatinase-associated lipocalin)|interpro:IPR012674(Calycin)|interpro:IPR022272|mint:P80188|rcsb pdb:1DFV|rcsb pdb:1L6M|rcsb pdb:1NGL|rcsb pdb:1QQS|rcsb pdb:1X71|rcsb pdb:1X89|rcsb pdb:1X8U|rcsb pdb:3BY0|rcsb pdb:3CBC|rcsb pdb:3CMP|rcsb pdb:3DSZ|rcsb pdb:3DTQ|rcsb pdb:3FW4|rcsb pdb:3FW5|rcsb pdb:3HWD|rcsb pdb:3HWE|rcsb pdb:3HWF|rcsb pdb:3HWG|rcsb pdb:3I0A|rcsb pdb:3K3L|rcsb pdb:3PEC|rcsb pdb:3PED|rcsb pdb:3T1D|rcsb pdb:3TF6|rcsb pdb:3TZS|rcsb pdb:3U0D|rcsb pdb:4GH7|rcsb pdb:4IAW|rcsb pdb:4IAX|rcsb pdb:4K19|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4QAE|rcsb pdb:4ZFX|rcsb pdb:4ZHC|rcsb pdb:4ZHD|rcsb pdb:4ZHF|rcsb pdb:4ZHG|rcsb pdb:4ZHH|rcsb pdb:5JR8|rcsb pdb:5KHP|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|rcsb pdb:5KIC|rcsb pdb:5KID|rcsb pdb:5MHH|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:5NKN|rcsb pdb:6GQZ|rcsb pdb:6GR0|rcsb pdb:6QMU|rcsb pdb:6S8V|rcsb pdb:6SUA|rcsb pdb:6Z2C|rcsb pdb:6Z6Z|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-917937|rcsb pdb:6O5D	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:m5Q9A8rMP15tT8/Sdt2q/a3Xsr89606	rigid:BWWnlc9+bjVKrMlUqWFBZmkpkdY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96GD4	intact:EBI-13613195	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047363|psi-mi:"MI:0471"|imex:IM-25807-192	author score:3.91	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	rigid:G0X+qXjJ0WWAamrAWQ/4ZFJ/bKA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P11474	intact:EBI-13613195	intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047375|psi-mi:"MI:0471"|imex:IM-25807-193	author score:3.93	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606	rigid:vDIfkbtDOIYS85n+PEXxuznwccM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P22314	intact:EBI-13613195	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047387|psi-mi:"MI:0471"|imex:IM-25807-194	author score:3.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:/p0DCDdwxckZU6A5CL9v5/gZ7M0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q13287	intact:EBI-13613195	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047399|psi-mi:"MI:0471"|imex:IM-25807-195	author score:30.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:Lbz8m5Uby4Z0EO57yYlyc9EcPr4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRH9	uniprotkb:P06921	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	intact:EBI-13613195	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333923(hpv05)|taxid:333923(hpv05)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047411|psi-mi:"MI:0471"|imex:IM-25807-196	author score:32.82	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rigid:G1DH1MqyCmC+TAWt3FO9A28/Qh8	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96T23	intact:EBI-13613195	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047423|psi-mi:"MI:0471"|imex:IM-25807-197	author score:34.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:3TmbdfsgOTRIkQWqTmerLrz6hqU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9Y244	intact:EBI-13613195	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047435|psi-mi:"MI:0471"|imex:IM-25807-198	author score:34.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:Sb4rlqo64q4GoCFmHh8kYW8v99o	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P16144	intact:EBI-13613195	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047447|psi-mi:"MI:0471"|imex:IM-25807-199	author score:34.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:QWNRMarhIOJtmy4veIyoHEIT0eE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9Y2S7	intact:EBI-13613195	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047459|psi-mi:"MI:0471"|imex:IM-25807-200	author score:36.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:rm8mC/KBor6cak/jgzjUjnW6yAA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q13227	intact:EBI-13613195	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047471|psi-mi:"MI:0471"|imex:IM-25807-201	author score:37.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:Oe3mdti8GW0S4212K4U8OCOcJuo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P20226	intact:EBI-13613195	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047483|psi-mi:"MI:0471"|imex:IM-25807-202	author score:38.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:jcdPngBsCNDwX53n1NFRG7nzg/E	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q16629	intact:EBI-13613195	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047291|imex:IM-25807-186|psi-mi:"MI:0471"	author score:280.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:IL/EXgKHYhtVFJbiJtg9Y7l3wuw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P15514	intact:EBI-13613195	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047567|psi-mi:"MI:0471"|imex:IM-25807-209	author score:5.40	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rigid:MIbbJIPJDjp0/C+a357hf0ZGy5A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q12834	intact:EBI-13613195	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047555|psi-mi:"MI:0471"|imex:IM-25807-208	author score:5.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rigid:kIYh3sb3e7RgqG3KbE9z4g+YueA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P26641	intact:EBI-13613195	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047543|psi-mi:"MI:0471"|imex:IM-25807-207	author score:5.32	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:S2F1zkVhgR6asNpRmC1Ryfovwsw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8IWI9	intact:EBI-13613195	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047531|psi-mi:"MI:0471"|imex:IM-25807-206	author score:46.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:tm02YM1NRBTyxy2c1E7+AhSs5MM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P22736	intact:EBI-13613195	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047519|psi-mi:"MI:0471"|imex:IM-25807-205	author score:44.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:bMp+zuDLPh5s9jtxS/76Od5WPbA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q07021	intact:EBI-13613195	intact:EBI-347528|uniprotkb:Q2HXR8|uniprotkb:Q9NNY8|intact:EBI-15990352|ensembl:ENSP00000225698	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:c1qbp_human(display_long)|uniprotkb:C1QBP(gene name)|psi-mi:C1QBP(display_short)|uniprotkb:GC1QBP(gene name synonym)|uniprotkb:HABP1(gene name synonym)|uniprotkb:SF2P32(gene name synonym)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:Hyaluronan-binding protein 1(gene name synonym)|uniprotkb:Mitochondrial matrix protein p32(gene name synonym)|uniprotkb:p33(gene name synonym)|uniprotkb:ASF/SF2-associated protein p32(gene name synonym)|uniprotkb:gC1q-R protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047507|psi-mi:"MI:0471"|imex:IM-25807-204	author score:4.26	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001203.1|dip:DIP-31164N|ensembl:ENSG00000108561(gene)|ensembl:ENST00000225698(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|mint:Q07021|rcsb pdb:1P32|rcsb pdb:3RPX|rcsb pdb:6SZW|reactome:R-HSA-111471|go:"GO:0005886"(plasma membrane)|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9645722|reactome:R-HSA-140837	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:NfZ31HjbYZxd8UQKRXczhpc306E9606	rigid:V8cWLhn/8p4IQynnPKXxwkQyxlg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8N2W9	intact:EBI-13613195	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047579|psi-mi:"MI:0471"|imex:IM-25807-210	author score:5.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:VtmgC2s7J/EDoiAeZCtoIvLc+04	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9BZF9	intact:EBI-13613195	intact:EBI-350510|uniprotkb:Q14DD3|uniprotkb:Q8N3B8|uniprotkb:Q9HCL1|uniprotkb:Q9NWC6|uniprotkb:G3XAG2|uniprotkb:Q96NH6|intact:EBI-10977773|ensembl:ENSP00000314556	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uaca_human(display_long)|uniprotkb:UACA(gene name)|psi-mi:UACA(display_short)|uniprotkb:KIAA1561(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047683|psi-mi:"MI:0471"|imex:IM-25807-217	author score:6.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001008225.1|refseq:NP_060473.2|dip:DIP-33117N|ensembl:ENSG00000137831(gene)|ensembl:ENST00000322954(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR030227|interpro:IPR036770|mint:Q9BZF9|reactome:R-HSA-9013407|reactome:R-HSA-9627069	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:F58VkGk2DBsUUrB+wgknUFZhJ+E9606	rigid:ZxXQCqvWQT3UYtoMNp2aetpX6F0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96QF0	intact:EBI-13613195	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047671|psi-mi:"MI:0471"|imex:IM-25807-216	author score:6.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:MfDMrODlU4Pg2P92KAhvyITqWXI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O43791	intact:EBI-13613195	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047659|psi-mi:"MI:0471"|imex:IM-25807-215	author score:59.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:O46E6hhiNnVe3uuze4CASIvr/x0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6Z7	uniprotkb:P06921	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	intact:EBI-13613195	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333923(hpv05)|taxid:333923(hpv05)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047611|psi-mi:"MI:0471"|imex:IM-25807-211	author score:5.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rigid:D9eRzLA9Cgh1SO+6EKGiU37x/1w	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O94842	intact:EBI-13613195	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047635|psi-mi:"MI:0471"|imex:IM-25807-213	author score:5.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:jfGJbHRLgv3FyAUKfh+JFvm8V7U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:O75925	intact:EBI-13613195	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047623|psi-mi:"MI:0471"|imex:IM-25807-212	author score:5.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rigid:QtvHRZbj4dL0wV8KQAGYP2CadXc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P13667	intact:EBI-13613195	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047647|psi-mi:"MI:0471"|imex:IM-25807-214	author score:5.81	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:hqsv18xMiQXERA+zos2SXTeJQIY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P04637	intact:EBI-15989725	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048079|psi-mi:"MI:0471"|imex:IM-25807-250	author score:4.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:JB8ToxMCkBrg2KWbYzoLkLKPIKE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9P086	intact:EBI-13613195	intact:EBI-394704|uniprotkb:Q6NS89|ensembl:ENSP00000293777	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:med11_human(display_long)|uniprotkb:Mediator complex subunit 11(gene name synonym)|uniprotkb:MED11(gene name)|psi-mi:MED11(display_short)|uniprotkb:HSPC296(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047695|psi-mi:"MI:0471"|imex:IM-25807-218	author score:6.84	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001291929.1|refseq:NP_001001683.1|ensembl:ENSG00000161920(gene)|ensembl:ENST00000293777(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019404|mint:Q9P086|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:y7SZi5hIo5aOatJSZi98Hqt082A9606	rigid:n/tig+H62EbRv0s+VuNN1LCI2Qs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q8NAP3	intact:EBI-15989725	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048055|psi-mi:"MI:0471"|imex:IM-25807-248	author score:4.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:o4l2Lf+aEBrEprqFUXbNdbbvyto	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q16236	intact:EBI-15989725	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048043|psi-mi:"MI:0471"|imex:IM-25807-247	author score:4.02	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:Uoh1XLV8AAtGlWvYQdtBN1l0kD0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P53365	intact:EBI-15989725	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048031|psi-mi:"MI:0471"|imex:IM-25807-246	author score:3.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:3R8dhqkEZtqFCpiVoq6qwJ1Q/PQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O95251	intact:EBI-15989725	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048019|psi-mi:"MI:0471"|imex:IM-25807-245	author score:3.93	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:zJtBxzBc8UmpxUWYTfkTDp0QwKQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q07955	intact:EBI-15989725	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048007|psi-mi:"MI:0471"|imex:IM-25807-244	author score:3.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:F3ueLGUxu9725nj5JxwUyA2vMjU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q16629	intact:EBI-15989725	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047995|psi-mi:"MI:0471"|imex:IM-25807-243	author score:3.84	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:WkshMo8udX7p7oUyuiXHWJJiYdM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9NRL2	intact:EBI-15989725	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047983|psi-mi:"MI:0471"|imex:IM-25807-242	author score:3.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:8oU+tr3azbBvpRY/j2Ds+I2bIVs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O60885	intact:EBI-15989725	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047971|psi-mi:"MI:0471"|imex:IM-25807-241	author score:27.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:GXplJdEf17mif8es3ZFG9ucUpvg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O43791	intact:EBI-15989725	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047959|psi-mi:"MI:0471"|imex:IM-25807-240	author score:26.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:p5NN6EXztTcINBQpR2yr38yU3qw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q86VP1	intact:EBI-15989725	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047947|psi-mi:"MI:0471"|imex:IM-25807-239	author score:22.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:MitcevjDDfh1DsbIRZIkUQLQ5ys	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P16144	intact:EBI-15989725	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047935|psi-mi:"MI:0471"|imex:IM-25807-238	author score:21.47	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:au/BEUuG607t9bn2BWAxE19XdQ8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q96QF0	intact:EBI-15989725	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047923|psi-mi:"MI:0471"|imex:IM-25807-237	author score:18.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:MnaLEXVBci+ZfafIrxtcbUVUCmY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q14790	intact:EBI-15989725	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047911|psi-mi:"MI:0471"|imex:IM-25807-236	author score:11.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:8NnNDXvxrATkkZ7A9MJQihN7cAI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86XZ4	uniprotkb:P06921	intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8	intact:EBI-13613195	psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name)	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333923(hpv05)|taxid:333923(hpv05)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047899|psi-mi:"MI:0471"|imex:IM-25807-235	author score:9.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rigid:nWC7tVuIe4I3H+aqzm1PgA3lnKE	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9NYY3	intact:EBI-13613195	intact:EBI-721354|uniprotkb:O60679|uniprotkb:Q96CV7|uniprotkb:Q9UE61|ensembl:ENSP00000274289	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:plk2_human(display_long)|uniprotkb:Polo-like kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SNK(gene name synonym)|uniprotkb:Serum-inducible kinase(gene name synonym)|uniprotkb:PLK2(gene name)|psi-mi:PLK2(display_short)|uniprotkb:SNK(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047887|psi-mi:"MI:0471"|imex:IM-25807-234	author score:9.98	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-48943N|refseq:NP_006613.2|refseq:NP_001239155.1|ensembl:ENSG00000145632(gene)|ensembl:ENST00000274289(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|interpro:IPR042825|rcsb pdb:4I5M|rcsb pdb:4I5P|rcsb pdb:4I6B|rcsb pdb:4I6F|rcsb pdb:4I6H|rcsb pdb:4RS6|rcsb pdb:4XB0|reactome:R-HSA-6804115|reactome:R-HSA-9662834	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:pjEqMnSG5E6daeauZylX38gmiS09606	rigid:t64WO2mggjB7k3IDs79M9P0/2X0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9UJY5	intact:EBI-13613195	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047875|psi-mi:"MI:0471"|imex:IM-25807-233	author score:9.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:iuqwurvhYoaJJsS7Eg1DWfDxUxk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q8N1B4	intact:EBI-13613195	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047863|psi-mi:"MI:0471"|imex:IM-25807-232	author score:84.82	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:KqPZFFyQBMjA93ktLipVOm7Xeb0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P50616	intact:EBI-13613195	intact:EBI-723281|uniprotkb:Q4KMQ0|intact:EBI-28983166|ensembl:ENSP00000268957|ensembl:ENSP00000427695|uniprotkb:B2R9T0|uniprotkb:D3DTY3	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tob1_human(display_long)|uniprotkb:Transducer of erbB-2 1(gene name synonym)|uniprotkb:TOB1(gene name)|psi-mi:TOB1(display_short)|uniprotkb:TOB(gene name synonym)|uniprotkb:TROB1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047851|psi-mi:"MI:0471"|imex:IM-25807-231	author score:8.81	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005740.1|refseq:NP_001230806.1|refseq:NP_001230814.1|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:P50616|rcsb pdb:2D5R|rcsb pdb:2Z15|rcsb pdb:5CI8|rcsb pdb:5CI9|go:"GO:0045668"(negative regulation of osteoblast differentiation)|ensembl:ENSG00000141232(gene)|ensembl:ENST00000268957(transcript)|ensembl:ENST00000499247(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|ensembl:ENSP00000268957|ensembl:ENSP00000427695	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:kJ3wPXuioip9D7MDuFmxnXTkP9w9606	rigid:KeitFjVThlDyokrT6FSFdoZJo9A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q13950	intact:EBI-13613195	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047839|imex:IM-25807-230|psi-mi:"MI:0471"	author score:8.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:BO8YEO9E6BtPxdBI46+XcJkGgBo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q14533	intact:EBI-13613195	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047827|imex:IM-25807-229|psi-mi:"MI:0471"	author score:8.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:z86ARbl8R8ov1nSipEgnhcxRvRU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P25787	intact:EBI-13613195	intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047815|imex:IM-25807-228|psi-mi:"MI:0471"	author score:7.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606	rigid:X4LBox5CoYWlxgWLLNd4vhvaeWA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:P06921	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-13613195	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:333923(hpv05)|taxid:333923(hpv05)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047803|imex:IM-25807-227|psi-mi:"MI:0471"	author score:7.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rigid:pd2LnuuRtZ4rWM7523KBESYRd/k	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9UM11	intact:EBI-13613195	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047791|imex:IM-25807-226|psi-mi:"MI:0471"	author score:7.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	rigid:kQSw/RXfXysLHrGRKwaiY45j5ms	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q96BR6	intact:EBI-13613195	intact:EBI-12006574|ensembl:ENSP00000342818|uniprotkb:B3KP94|uniprotkb:Q5VT39|uniprotkb:Q9H9Q6	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zn669_human(display_long)|uniprotkb:ZNF669(gene name)|psi-mi:ZNF669(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047779|imex:IM-25807-225|psi-mi:"MI:0471"	author score:7.27	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000188295(gene)|ensembl:ENST00000343381(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|reactome:R-HSA-212436|refseq:NP_001136044.1|refseq:NP_079080.2	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:Z3QU2mbmgGdKBQ8UP4q4EfafeMc9606	rigid:y8KAYY30DDlkWudWjEmM9G73chE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P62158	intact:EBI-13613195	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047767|imex:IM-25807-224|psi-mi:"MI:0471"	author score:7.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:bWYpcyTTI/UJOXBEc9Uj7t7LT4k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P04792	intact:EBI-13613195	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047755|imex:IM-25807-223|psi-mi:"MI:0471"	author score:7.06	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:fesdQANVxTAoXDi3juC8vXCoisc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:P06733	intact:EBI-13613195	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047743|imex:IM-25807-222|psi-mi:"MI:0471"	author score:7.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:8Zpi3GqWZycSUtqZI/JPFwS3YUU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9BXK5	intact:EBI-13613195	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047731|imex:IM-25807-221|psi-mi:"MI:0471"	author score:67.06	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:xU859TVN5/P5Qc+SVDuCc1Ye2jQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q66K74	intact:EBI-13613195	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047719|psi-mi:"MI:0471"|imex:IM-25807-220	author score:62.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:fKJM4JScHpLLjXxTf2LMrphwXOs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06921	uniprotkb:Q9NZV6	intact:EBI-13613195	intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1	psi-mi:ve2_hpv05(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333923(hpv05)|taxid:333923(hpv05)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16047707|psi-mi:"MI:0471"|imex:IM-25807-219	author score:6.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041368.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:oXH84JME0bxieQSz+bpQBSjftoI333923	rogid:DR4z/+yUfitTjUy4b722w3qyTk89606	rigid:sr3bTqaXvCOYWRM2i/REEMtN1p0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q8IWI9	intact:EBI-15989725	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048067|psi-mi:"MI:0471"|imex:IM-25807-249	author score:4.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:TIHl6WBJkkWDz1Nkln4EnOnB+6Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9Y570	intact:EBI-15989725	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048211|imex:IM-25807-261|psi-mi:"MI:0471"	author score:9.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:B4n/T8tPXrrn9vA58BoKJY1kuQQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q01130	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048223|imex:IM-25807-262|psi-mi:"MI:0471"	author score:10.00	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	rigid:kYg3CFXUho/VZw7cG+ZGHYV4tqI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q96T23	intact:EBI-15989725	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048187|psi-mi:"MI:0471"|imex:IM-25807-259	author score:8.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:V8WTeUYNuoAwYJVkYOdFWtRZgNo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q8N1B4	intact:EBI-15989725	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048175|psi-mi:"MI:0471"|imex:IM-25807-258	author score:7.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:ryEMjk8xLa9C78IbZwzRLEpzQ9Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O94842	intact:EBI-15989725	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048163|psi-mi:"MI:0471"|imex:IM-25807-257	author score:7.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:sA79XjaO4hllLotVFJEAqu8HXTo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P22736	intact:EBI-15989725	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048151|psi-mi:"MI:0471"|imex:IM-25807-256	author score:6.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:gKznATPzvimwEzJO/LEZnU2kssQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:P20226	intact:EBI-15989725	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048139|psi-mi:"MI:0471"|imex:IM-25807-255	author score:6.84	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:NLrcElDTckmV/LmESSHPjf6GCoo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O14735	intact:EBI-15989725	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048127|psi-mi:"MI:0471"|imex:IM-25807-254	author score:6.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:K3T9erb2iK6FlViU6W1VnYunKKE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9Y2S7	intact:EBI-15989725	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048115|psi-mi:"MI:0471"|imex:IM-25807-253	author score:5.87	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:jwo1T6k3FmILj2po6N+szzLVkFA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:O95235	intact:EBI-15989725	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048103|psi-mi:"MI:0471"|imex:IM-25807-252	author score:5.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:a7NXSK0IzKHYJ00rIIkJARRKZCs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q13287	intact:EBI-15989725	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048091|psi-mi:"MI:0471"|imex:IM-25807-251	author score:4.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:Lm+X8YkZ7Vtg7/C/m+chJaHMC/A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O60885	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048511|psi-mi:"MI:0471"|imex:IM-25807-286	author score:200.90	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:bOsv9q4+6g7WdcRwCZC9zx9SAxo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q96JC1	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048499|psi-mi:"MI:0471"|imex:IM-25807-285	author score:20.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:GhIJO/WaVlFqVwrpu4CtVz5cO58	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O15305	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048487|psi-mi:"MI:0471"|imex:IM-25807-284	author score:19.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:pAVxKFixCovqv2JvfclPiWIV4rU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O00308	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048475|psi-mi:"MI:0471"|imex:IM-25807-283	author score:19.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:Lrlh7pcsjX5erOsvkLD1nTfoAU8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q07955	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048463|psi-mi:"MI:0471"|imex:IM-25807-282	author score:183.54	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:fRpH9O4QppN1ZAQJ2ueGFY8BkiQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O14735	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048451|psi-mi:"MI:0471"|imex:IM-25807-281	author score:18.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:Tt4Y3WHmNur/WXBt0BMsM6tztL4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9NY93	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048439|psi-mi:"MI:0471"|imex:IM-25807-280	author score:18.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:u4jpayeV+wfe6J3/q8uOR2VQw80	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q15365	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048427|psi-mi:"MI:0471"|imex:IM-25807-279	author score:17.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:4VrbE9/a17gJzf1R509uNzjL36I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P04637	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048415|psi-mi:"MI:0471"|imex:IM-25807-278	author score:17.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:EmvFFn8pga3W1Wa0Qs7ES2gZcqM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9UHY1	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048403|psi-mi:"MI:0471"|imex:IM-25807-277	author score:17.02	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:aGDsTSYTadduPvtT0uko7UnK4IU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9Y244	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048391|psi-mi:"MI:0471"|imex:IM-25807-276	author score:16.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:zrySsXW5WEi577ylotnmUJxvI8E	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q96KG9	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048379|psi-mi:"MI:0471"|imex:IM-25807-275	author score:16.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:cTAC2OBTk0GiyVKyS+LJgKV+EOc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q13227	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048367|psi-mi:"MI:0471"|imex:IM-25807-274	author score:14.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:BZbNiwmxUmTwkUQ/JHunNZU+DhU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q8WWH5	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048355|psi-mi:"MI:0471"|imex:IM-25807-273	author score:14.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:TDhjNOobxOFwxRGWxpAdTl+Ozms	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P22314	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048343|psi-mi:"MI:0471"|imex:IM-25807-272	author score:14.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:NwgejJBFnTX/syl+LTB2D1ZxL0A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q16236	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048331|psi-mi:"MI:0471"|imex:IM-25807-271	author score:13.45	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:qIV8zIGZE7Via9RlGpRR6h0ALso	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q8IWX8	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2555370|uniprotkb:O00302|uniprotkb:Q99492|uniprotkb:Q4G0Y5|uniprotkb:Q8WU30|ensembl:ENSP00000439856	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cherp_human(display_long)|uniprotkb:DAN26(gene name synonym)|uniprotkb:SCAF6(gene name synonym)|uniprotkb:SR-related CTD-associated factor 6(gene name synonym)|uniprotkb:ERPROT 213-21(gene name synonym)|uniprotkb:CHERP(gene name)|psi-mi:CHERP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048319|imex:IM-25807-270|psi-mi:"MI:0471"	author score:12.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006378.3|ensembl:ENSG00000085872(gene)|ensembl:ENST00000546361(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000467(D111/G-patch)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035967|interpro:IPR039037|reactome:R-HSA-72163	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:Snifq3RgcsxZ8r9MCExHeb242Ss9606	rigid:TaFMIr3HjFf6ud1BeXnFExFYZbQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O95235	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048307|imex:IM-25807-269|psi-mi:"MI:0471"	author score:11.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:EURdGRY1hZf4Bdqs3WRoOnlH4IY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P11021	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048295|imex:IM-25807-268|psi-mi:"MI:0471"	author score:11.65	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:nG9sB+nrIxKjyZEPoYmM3ByK9aY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q14790	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048283|imex:IM-25807-267|psi-mi:"MI:0471"	author score:11.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:HsTIGk4Zpz87dseeiPrvXFnZIbY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q5VT06	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048271|imex:IM-25807-266|psi-mi:"MI:0471"	author score:11.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:4AQ7NyXnofQBFlt+QPuwOE8Zgr4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P02538	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048259|imex:IM-25807-265|psi-mi:"MI:0471"	author score:10.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:QeBbIsU774XIzmcTg3DdAVCS1Rs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9BVW5	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048247|imex:IM-25807-264|psi-mi:"MI:0471"	author score:10.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:To4ZDhoXhgUfP6tpkS3ISNrYowI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q8NAP3	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048235|imex:IM-25807-263|psi-mi:"MI:0471"	author score:10.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:xvNID68wpKSd5UlGuEy9ARQo9VA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q77UU1	uniprotkb:Q9BXK5	intact:EBI-15989725	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:q77uu1_9papi(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:31552(human papillomavirus type 6)|taxid:31552(Human papillomavirus type 6)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048199|psi-mi:"MI:0471"|imex:IM-25807-260	author score:8.83	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DZpBXY5DjvOkgZgzJF5HZSv0Pnk31552	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:HJWRUZ01XArvveKgHXhGk0OXhFY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9NRL2	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048799|imex:IM-25807-310|psi-mi:"MI:0471"	author score:43.33	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:SESo89OFbXmtl2rZ3xq684F/ThI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P16144	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048523|psi-mi:"MI:0471"|imex:IM-25807-287	author score:21.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:KBWYRmTAEG6gCnYGd3tb8DwV4qw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P62158	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048775|imex:IM-25807-308|psi-mi:"MI:0471"	author score:4.87	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:Fld+zwenv4zfFs1wSFP0WtN9W64	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P25787	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048763|imex:IM-25807-307|psi-mi:"MI:0471"	author score:4.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606	rigid:Qmx44EKjBFvUtFtTGsnjQI7LYh4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P50616	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-723281|uniprotkb:Q4KMQ0|intact:EBI-28983166|ensembl:ENSP00000268957|ensembl:ENSP00000427695|uniprotkb:B2R9T0|uniprotkb:D3DTY3	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tob1_human(display_long)|uniprotkb:Transducer of erbB-2 1(gene name synonym)|uniprotkb:TOB1(gene name)|psi-mi:TOB1(display_short)|uniprotkb:TOB(gene name synonym)|uniprotkb:TROB1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048751|imex:IM-25807-306|psi-mi:"MI:0471"	author score:4.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005740.1|refseq:NP_001230806.1|refseq:NP_001230814.1|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:P50616|rcsb pdb:2D5R|rcsb pdb:2Z15|rcsb pdb:5CI8|rcsb pdb:5CI9|go:"GO:0045668"(negative regulation of osteoblast differentiation)|ensembl:ENSG00000141232(gene)|ensembl:ENST00000268957(transcript)|ensembl:ENST00000499247(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|ensembl:ENSP00000268957|ensembl:ENSP00000427695	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:kJ3wPXuioip9D7MDuFmxnXTkP9w9606	rigid:2FnIL3tXrIBsjGJ89gGW6P/o7rc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P15514	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048739|imex:IM-25807-305|psi-mi:"MI:0471"	author score:4.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rigid:/kS6pGVeXzebFmuEfKgAHD+cvpw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q14289	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048727|imex:IM-25807-304|psi-mi:"MI:0471"	author score:4.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:PUrbOdwxWHMdRq8t/yHMYoYBNd0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q13309	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048715|imex:IM-25807-303|psi-mi:"MI:0471"	author score:4.27	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606	rigid:mcFx+25iR6Zb4aKr/RxggFFA/x4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P06733	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048703|imex:IM-25807-302|psi-mi:"MI:0471"	author score:4.18	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:WlEDywdhNQgUk2+RsZcTlIRe3cs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9BRH9	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048691|imex:IM-25807-301|psi-mi:"MI:0471"	author score:38.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rigid:J5SifBQZzkBBkBJtaYEhl6PUWcw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q8N1B4	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048679|psi-mi:"MI:0471"|imex:IM-25807-300	author score:36.25	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:c264IK22uAsMlOmYELkXXntaIbM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q96T23	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048667|psi-mi:"MI:0471"|imex:IM-25807-299	author score:34.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:lu9/V9FW8ceT0xv+AvboXkyXN74	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P51523	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2849074|uniprotkb:Q9UC18|uniprotkb:Q86XU8|uniprotkb:Q3ZCV9|uniprotkb:Q9NNX7|uniprotkb:Q9UC17|uniprotkb:B2RAK5|uniprotkb:Q5D057|uniprotkb:D3DXJ1|ensembl:ENSP00000331465|ensembl:ENSP00000376133|ensembl:ENSP00000445549	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:znf84_human(display_long)|uniprotkb:ZNF84(gene name)|psi-mi:ZNF84(display_short)|uniprotkb:Zinc finger protein HPF2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048655|psi-mi:"MI:0471"|imex:IM-25807-298	author score:34.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_011533134.1|refseq:NP_001276900.1|refseq:NP_001276901.1|refseq:NP_001120844.1|refseq:NP_003419.3|refseq:XP_005266242.1|refseq:XP_005266243.1|ensembl:ENST00000327668(transcript)|ensembl:ENST00000392319(transcript)|ensembl:ENST00000539354(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|ensembl:ENSG00000198040(gene)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:zsEc/0um2BHfMbCHJ7GFoH9Qwfo9606	rigid:FQ8Ftzg7it1r8rK/cPVOtgKwlCU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P22736	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048643|psi-mi:"MI:0471"|imex:IM-25807-297	author score:32.00	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:axBnOWwOcDokaRnhafE8FwIca6Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9BXK5	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048631|psi-mi:"MI:0471"|imex:IM-25807-296	author score:31.86	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:10IxOdZoG3iL9zKDIB20PTLo5XE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9NYY3	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-721354|uniprotkb:O60679|uniprotkb:Q96CV7|uniprotkb:Q9UE61|ensembl:ENSP00000274289	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:plk2_human(display_long)|uniprotkb:Polo-like kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SNK(gene name synonym)|uniprotkb:Serum-inducible kinase(gene name synonym)|uniprotkb:PLK2(gene name)|psi-mi:PLK2(display_short)|uniprotkb:SNK(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048619|psi-mi:"MI:0471"|imex:IM-25807-295	author score:3.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-48943N|refseq:NP_006613.2|refseq:NP_001239155.1|ensembl:ENSG00000145632(gene)|ensembl:ENST00000274289(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|interpro:IPR042825|rcsb pdb:4I5M|rcsb pdb:4I5P|rcsb pdb:4I6B|rcsb pdb:4I6F|rcsb pdb:4I6H|rcsb pdb:4RS6|rcsb pdb:4XB0|reactome:R-HSA-6804115|reactome:R-HSA-9662834	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:pjEqMnSG5E6daeauZylX38gmiS09606	rigid:fFTHp+aSi+gW6hhAwu7mgoksti0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P80188	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-11911016|uniprotkb:A6NII8|uniprotkb:B4DWV4|uniprotkb:B7ZAA2|uniprotkb:P30150|uniprotkb:Q5SYV9|uniprotkb:Q5SYW0|uniprotkb:Q6FGL5|uniprotkb:Q92683|ensembl:ENSP00000277480|ensembl:ENSP00000362108	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ngal_human(display_long)|uniprotkb:Siderocalin(gene name synonym)|uniprotkb:LCN2(gene name)|psi-mi:LCN2(display_short)|uniprotkb:25 kDa alpha-2-microglobulin-related subunit of MMP-9(gene name synonym)|uniprotkb:HNL(gene name synonym)|uniprotkb:Lipocalin-2(gene name synonym)|uniprotkb:NGAL(gene name synonym)|uniprotkb:Oncogene 24p3(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048607|psi-mi:"MI:0471"|imex:IM-25807-294	author score:3.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005555.2|dip:DIP-29952N|ensembl:ENSG00000148346(gene)|ensembl:ENST00000277480(transcript)|ensembl:ENST00000373017(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0009635"(response to herbicide)|go:"GO:0009637"(response to blue light)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015891"(siderophore transport)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036094"(small molecule binding)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0042493"|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0097577"(sequestering of iron ion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903981"(enterobactin binding)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR003087(Neutrophil gelatinase-associated lipocalin)|interpro:IPR012674(Calycin)|interpro:IPR022272|mint:P80188|rcsb pdb:1DFV|rcsb pdb:1L6M|rcsb pdb:1NGL|rcsb pdb:1QQS|rcsb pdb:1X71|rcsb pdb:1X89|rcsb pdb:1X8U|rcsb pdb:3BY0|rcsb pdb:3CBC|rcsb pdb:3CMP|rcsb pdb:3DSZ|rcsb pdb:3DTQ|rcsb pdb:3FW4|rcsb pdb:3FW5|rcsb pdb:3HWD|rcsb pdb:3HWE|rcsb pdb:3HWF|rcsb pdb:3HWG|rcsb pdb:3I0A|rcsb pdb:3K3L|rcsb pdb:3PEC|rcsb pdb:3PED|rcsb pdb:3T1D|rcsb pdb:3TF6|rcsb pdb:3TZS|rcsb pdb:3U0D|rcsb pdb:4GH7|rcsb pdb:4IAW|rcsb pdb:4IAX|rcsb pdb:4K19|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4QAE|rcsb pdb:4ZFX|rcsb pdb:4ZHC|rcsb pdb:4ZHD|rcsb pdb:4ZHF|rcsb pdb:4ZHG|rcsb pdb:4ZHH|rcsb pdb:5JR8|rcsb pdb:5KHP|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|rcsb pdb:5KIC|rcsb pdb:5KID|rcsb pdb:5MHH|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:5NKN|rcsb pdb:6GQZ|rcsb pdb:6GR0|rcsb pdb:6QMU|rcsb pdb:6S8V|rcsb pdb:6SUA|rcsb pdb:6Z2C|rcsb pdb:6Z6Z|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-917937|rcsb pdb:6O5D	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:m5Q9A8rMP15tT8/Sdt2q/a3Xsr89606	rigid:h6FH/AGa6bmAnyEdSpBhemT+MOM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6Z7	uniprotkb:P06422	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048595|psi-mi:"MI:0471"|imex:IM-25807-293	author score:3.61	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rigid:Qn72d4B9E+4Ho0culyxGz6Jvkzs	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q8IWI9	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048583|psi-mi:"MI:0471"|imex:IM-25807-292	author score:28.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:7scNmkQlYlgRXexwq0FCA2yCQyU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P20226	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048571|psi-mi:"MI:0471"|imex:IM-25807-291	author score:27.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:CXi9G/ZKFChLhSScx23roYdtMrc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q66K74	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048559|psi-mi:"MI:0471"|imex:IM-25807-290	author score:26.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:5PfnSiAalxE9i8nVxsXXpz/T7T4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9Y2S7	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048547|psi-mi:"MI:0471"|imex:IM-25807-289	author score:25.79	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:KJ/0itIZlkAZzc1MA4SR+evKjyE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q07817	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048535|psi-mi:"MI:0471"|imex:IM-25807-288	author score:25.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:2CsyAB66UB11Gqnw9gACXBhJDeU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q13287	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048787|imex:IM-25807-309|psi-mi:"MI:0471"	author score:40.06	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:QOKnCffyNPAOwPW0fs5GDTKmEK0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q8WWY3	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048944|psi-mi:"MI:0471"|imex:IM-25807-321	author score:5.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:kruYa4fi3alaW/yHxP6Cel1b3FU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9NZV6	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048956|psi-mi:"MI:0471"|imex:IM-25807-322	author score:5.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:DR4z/+yUfitTjUy4b722w3qyTk89606	rigid:nLZnypuDvKaGMLgxX1kDQzBb64Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q96QE5	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048920|psi-mi:"MI:0471"|imex:IM-25807-319	author score:5.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:+fHpntqrXG4FIVdeGEDy9wdhbsE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9UM11	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048908|psi-mi:"MI:0471"|imex:IM-25807-318	author score:5.70	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	rigid:gyLycQuiMmgGhtxWo3Y/kD/1M1A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q13950	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048896|psi-mi:"MI:0471"|imex:IM-25807-317	author score:5.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:vnu+1ZKgJoqZUspBrXNR2ZOkfV4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9BZF9	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-350510|uniprotkb:Q14DD3|uniprotkb:Q8N3B8|uniprotkb:Q9HCL1|uniprotkb:Q9NWC6|uniprotkb:G3XAG2|uniprotkb:Q96NH6|intact:EBI-10977773|ensembl:ENSP00000314556	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uaca_human(display_long)|uniprotkb:UACA(gene name)|psi-mi:UACA(display_short)|uniprotkb:KIAA1561(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048884|psi-mi:"MI:0471"|imex:IM-25807-316	author score:5.31	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001008225.1|refseq:NP_060473.2|dip:DIP-33117N|ensembl:ENSG00000137831(gene)|ensembl:ENST00000322954(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR030227|interpro:IPR036770|mint:Q9BZF9|reactome:R-HSA-9013407|reactome:R-HSA-9627069	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:F58VkGk2DBsUUrB+wgknUFZhJ+E9606	rigid:PQDNwET76KzN3tZ9W5Fm2/MfjDM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O94842	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048872|psi-mi:"MI:0471"|imex:IM-25807-315	author score:5.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:Hyw8zDP0PjMQMhDVk78K6OOSvrc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P53365	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048860|psi-mi:"MI:0471"|imex:IM-25807-314	author score:48.53	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:hzC9S9cN9YH0v0H13Yp8o+6kRW0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q86VP1	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048848|psi-mi:"MI:0471"|imex:IM-25807-313	author score:48.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:2Y8YZUYpAbfw1ZWMonnDqSYqRoU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O43791	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048836|psi-mi:"MI:0471"|imex:IM-25807-312	author score:47.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:rOrrnNLtQRzAKnI8dUEDAeHRc3o	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:O95251	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048824|psi-mi:"MI:0471"|imex:IM-25807-311	author score:44.61	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:TK/GOS7oAdTKdmy0YLRpL2OpQMs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q14533	intact:EBI-13612615	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049256|imex:IM-25807-347|psi-mi:"MI:0471"	author score:15.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:mPlYVvA1+iNsXgM4wy6dUXs222c	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q14790	intact:EBI-13612615	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049244|imex:IM-25807-346|psi-mi:"MI:0471"	author score:14.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:TSJgWrrXN89vbPbyWvD9XLwhfLs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q5VT06	intact:EBI-13612615	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049232|imex:IM-25807-345|psi-mi:"MI:0471"	author score:14.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:PK1THyAm0lxiWS7Fvm/wYu7uPMc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q07955	intact:EBI-13612615	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049220|imex:IM-25807-344|psi-mi:"MI:0471"	author score:127.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:d9ZekHjqbuYKSICxJ5TqEIKVdYM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P62158	intact:EBI-13612615	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049208|imex:IM-25807-343|psi-mi:"MI:0471"	author score:12.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:3nqkMotUcvB52dmlVvljEebzrzg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8IWX8	intact:EBI-13612615	intact:EBI-2555370|uniprotkb:O00302|uniprotkb:Q99492|uniprotkb:Q4G0Y5|uniprotkb:Q8WU30|ensembl:ENSP00000439856	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cherp_human(display_long)|uniprotkb:DAN26(gene name synonym)|uniprotkb:SCAF6(gene name synonym)|uniprotkb:SR-related CTD-associated factor 6(gene name synonym)|uniprotkb:ERPROT 213-21(gene name synonym)|uniprotkb:CHERP(gene name)|psi-mi:CHERP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049196|imex:IM-25807-342|psi-mi:"MI:0471"	author score:12.47	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006378.3|ensembl:ENSG00000085872(gene)|ensembl:ENST00000546361(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000467(D111/G-patch)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035967|interpro:IPR039037|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:Snifq3RgcsxZ8r9MCExHeb242Ss9606	rigid:YXkpfLAm3YYsdcIokdKJ9VIKyxo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96JC1	intact:EBI-13612615	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049184|imex:IM-25807-341|psi-mi:"MI:0471"	author score:114.54	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:Ni67F6PKBo6okfrC2lxQqiGBrOs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96QF0	intact:EBI-13612615	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049172|psi-mi:"MI:0471"|imex:IM-25807-340	author score:11.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:V2rkGfvEiZdibHmhlC1Jmg/2/ug	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:P36780	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-13612615	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049160|psi-mi:"MI:0471"|imex:IM-25807-339	author score:11.07	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:QsyTGeScgvjyDxmWYIjQdo7k3MA	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q92905	intact:EBI-13612615	intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049148|psi-mi:"MI:0471"|imex:IM-25807-338	author score:11.07	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606	rigid:mnyNLYsEa5kIZoaPyKOO5aGq8Nk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9BZF9	intact:EBI-13612615	intact:EBI-350510|uniprotkb:Q14DD3|uniprotkb:Q8N3B8|uniprotkb:Q9HCL1|uniprotkb:Q9NWC6|uniprotkb:G3XAG2|uniprotkb:Q96NH6|intact:EBI-10977773|ensembl:ENSP00000314556	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uaca_human(display_long)|uniprotkb:UACA(gene name)|psi-mi:UACA(display_short)|uniprotkb:KIAA1561(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049136|psi-mi:"MI:0471"|imex:IM-25807-337	author score:10.98	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001008225.1|refseq:NP_060473.2|dip:DIP-33117N|ensembl:ENSG00000137831(gene)|ensembl:ENST00000322954(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR030227|interpro:IPR036770|mint:Q9BZF9|reactome:R-HSA-9013407|reactome:R-HSA-9627069	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:F58VkGk2DBsUUrB+wgknUFZhJ+E9606	rigid:ybDpqS+pqt179cRqUjjvTnFGXNA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P55209	intact:EBI-13612615	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049124|psi-mi:"MI:0471"|imex:IM-25807-336	author score:10.02	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:3qxxUh4nXpUiCQ8Vj7gjWzh0UFc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9UJY5	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049112|psi-mi:"MI:0471"|imex:IM-25807-335	author score:9.26	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:ggu+2ke5Trn83SYP92B2WYHOjo4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P04792	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049100|psi-mi:"MI:0471"|imex:IM-25807-334	author score:8.98	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:POxjEm5JvGF345nnxCveqgwpBjQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q12834	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049088|psi-mi:"MI:0471"|imex:IM-25807-333	author score:8.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rigid:+wrnqOiQC7t07tTDXRc63j9Qrlw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q99698	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-2830208|uniprotkb:Q5T2U9|uniprotkb:O43274|uniprotkb:Q96TD8|uniprotkb:Q96TD7|uniprotkb:Q9H133|uniprotkb:Q99709|ensembl:ENSP00000374443	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:lyst_human(display_long)|uniprotkb:LYST(gene name)|psi-mi:LYST(display_short)|uniprotkb:CHS(gene name synonym)|uniprotkb:CHS1(gene name synonym)|uniprotkb:Beige homolog(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049076|psi-mi:"MI:0471"|imex:IM-25807-332	author score:8.72	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001288294.1|ensembl:ENSG00000143669(gene)|ensembl:ENST00000389793(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0007040"(lysosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032438"(melanosome organization)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043473"(pigmentation)|go:"GO:0051607"(defense response to virus)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019775|interpro:IPR023362|interpro:IPR030464|interpro:IPR036322|interpro:IPR036372|refseq:NP_000072.2	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:vO+yDuFmFJ9TEmQ7JeUpni4mguY9606	rigid:DDWmfMKelPDSFpJRt39lyYN1GJw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P55209	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049064|psi-mi:"MI:0471"|imex:IM-25807-331	author score:8.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:ZhQYS2ld2DTWXeaLnC21jOsVQnM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q16629	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049052|psi-mi:"MI:0471"|imex:IM-25807-330	author score:782.45	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:NPq9HuCnvfiGy8BHVT0XaVXoIQg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9Y570	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049040|psi-mi:"MI:0471"|imex:IM-25807-329	author score:7.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:Nqt6Lxmj56xvSpWNBzg1b3JiBPk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q13813	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049028|psi-mi:"MI:0471"|imex:IM-25807-328	author score:7.16	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:orH0G6bTMuxauHbtlvGNhrgeRN0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P13667	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049016|psi-mi:"MI:0471"|imex:IM-25807-327	author score:7.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:tb3lVGpkvji4vMGzJ8B+hV+FudQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:P31274	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049004|psi-mi:"MI:0471"|imex:IM-25807-326	author score:7.01	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:lAgeBRh0INSvM/D4iwEwZeOToTk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q86XZ4	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048992|psi-mi:"MI:0471"|imex:IM-25807-325	author score:6.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606	rigid:+sqZjbwrTi+5aYLhLRUaN3zK/Wo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q9GZP9	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048980|psi-mi:"MI:0471"|imex:IM-25807-324	author score:6.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rigid:nNGbbT0BMtU8kw0pjBPaiHoL1+E	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q96QF0	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048968|psi-mi:"MI:0471"|imex:IM-25807-323	author score:6.36	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:TVS3P2gal4J6Q/piBRaThFGbq+c	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06422	uniprotkb:Q14533	intact:EBI-7136851|intact:EBI-15990415|intact:MINT-248448	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv08(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10579(hpv08)|taxid:10579(Human papillomavirus type 8)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16048932|psi-mi:"MI:0471"|imex:IM-25807-320	author score:5.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|interpro:IPR033668|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:kfMoZd0a3Afrfai4g9LKk3dnLcs10579	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:roPXndDr//gxBegjwlkrDHK5Wvs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7Z6Z7	uniprotkb:P36780	intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648	intact:EBI-13612615	psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049712|imex:IM-25807-385|psi-mi:"MI:0471"	author score:4.63	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:4Gtob4kGdePCCxE+XQ5YJXvPLuY	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96GD4	intact:EBI-13612615	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049700|imex:IM-25807-384|psi-mi:"MI:0471"	author score:4.56	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	rigid:7XmugIvSp+nLUFA1kJwEpsSv/Ys	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P22314	intact:EBI-13612615	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049688|imex:IM-25807-383|psi-mi:"MI:0471"	author score:4.43	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:K/uAQB1EaGkTWYWehCdSF7VcSJM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q13227	intact:EBI-13612615	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049676|imex:IM-25807-382|psi-mi:"MI:0471"	author score:38.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:EgNDMy6H+CtuS9+OuUPmXrFLqN4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8NAP3	intact:EBI-13612615	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049664|imex:IM-25807-381|psi-mi:"MI:0471"	author score:38.02	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:aMo2rF4qBwKZRzHmR+P9os2Cox0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O00308	intact:EBI-13612615	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049652|psi-mi:"MI:0471"|imex:IM-25807-380	author score:37.36	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:9Jvi3ZvMLNFs03bXJrr1KuB4Www	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9BXK5	intact:EBI-13612615	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049640|psi-mi:"MI:0471"|imex:IM-25807-379	author score:33.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:HzHYqeV5edbNdIRZpd9i28AFPd8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRH9	uniprotkb:P36780	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	intact:EBI-13612615	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049628|psi-mi:"MI:0471"|imex:IM-25807-378	author score:32.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:tIwnInDVCNtzhVnGJTXqtG2vwxg	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P04637	intact:EBI-13612615	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049616|psi-mi:"MI:0471"|imex:IM-25807-377	author score:31.42	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:JuRTjpAXA9A+HFsyVMxoc1t9jn4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O14735	intact:EBI-13612615	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049604|psi-mi:"MI:0471"|imex:IM-25807-376	author score:31.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:Ji09YeUkWQ0ync/98wlDYKrZEWs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9NY93	intact:EBI-13612615	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049592|psi-mi:"MI:0471"|imex:IM-25807-375	author score:31.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:6r53JUReKglIEcDIS09yrQptmoM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q15365	intact:EBI-13612615	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049580|psi-mi:"MI:0471"|imex:IM-25807-374	author score:30.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:1emPXjIFVBc7Tv1UBgaruSc3O0I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q13309	intact:EBI-13612615	intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049568|psi-mi:"MI:0471"|imex:IM-25807-373	author score:3.70	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606	rigid:fpAedXnWrzwHCeXjss0vnHUieXo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9H5V8	intact:EBI-13612615	intact:EBI-1019736|uniprotkb:Q49UB4|uniprotkb:Q6NT71|uniprotkb:Q6U9Y2|uniprotkb:Q8WU91|uniprotkb:Q96QU7|uniprotkb:Q9H676|uniprotkb:Q9H8C2|ensembl:ENSP00000296129	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdcp1_human(display_long)|uniprotkb:CDCP1(gene name)|psi-mi:CDCP1(display_short)|uniprotkb:TRASK(gene name synonym)|uniprotkb:UNQ2486/PRO5773(orf name)|uniprotkb:Transmembrane and associated with src kinases(gene name synonym)|uniprotkb:Membrane glycoprotein gp140(gene name synonym)|uniprotkb:Subtractive immunization M plus HEp3-associated 135 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049556|psi-mi:"MI:0471"|imex:IM-25807-372	author score:3.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_073753.3|refseq:NP_835488.1|dip:DIP-33861N|ensembl:ENSG00000163814(gene)|ensembl:ENST00000296129(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR035914|interpro:IPR038811	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:sAXK+WNzP2qtJ53Fu6+cuehNA289606	rigid:RSrwIhnclh68OMOiSz3nDUZo72s	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P16144	intact:EBI-13612615	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049544|psi-mi:"MI:0471"|imex:IM-25807-371	author score:29.72	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:cXH8wblkRdoWRbl4RUQ/JeDy+lk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P04792	intact:EBI-13612615	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049532|psi-mi:"MI:0471"|imex:IM-25807-370	author score:27.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:jZ3evLSb83PaI6lEr8AbdC/q8Y0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8IWI9	intact:EBI-13612615	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049520|psi-mi:"MI:0471"|imex:IM-25807-369	author score:26.55	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:xdYnhLL/1fczJ2rFkchelE/gHwc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P20226	intact:EBI-13612615	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049508|psi-mi:"MI:0471"|imex:IM-25807-368	author score:25.48	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:tj3/3OmoKjmxUVY13OgI186Vyww	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P51523	intact:EBI-13612615	intact:EBI-2849074|uniprotkb:Q9UC18|uniprotkb:Q86XU8|uniprotkb:Q3ZCV9|uniprotkb:Q9NNX7|uniprotkb:Q9UC17|uniprotkb:B2RAK5|uniprotkb:Q5D057|uniprotkb:D3DXJ1|ensembl:ENSP00000331465|ensembl:ENSP00000376133|ensembl:ENSP00000445549	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:znf84_human(display_long)|uniprotkb:ZNF84(gene name)|psi-mi:ZNF84(display_short)|uniprotkb:Zinc finger protein HPF2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049496|psi-mi:"MI:0471"|imex:IM-25807-367	author score:24.95	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_011533134.1|refseq:NP_001276900.1|refseq:NP_001276901.1|refseq:NP_001120844.1|refseq:NP_003419.3|refseq:XP_005266242.1|refseq:XP_005266243.1|ensembl:ENST00000327668(transcript)|ensembl:ENST00000392319(transcript)|ensembl:ENST00000539354(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|ensembl:ENSG00000198040(gene)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:zsEc/0um2BHfMbCHJ7GFoH9Qwfo9606	rigid:CssWXYhPcko6FPFn2620Cccrptw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9UJY5	intact:EBI-13612615	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049484|psi-mi:"MI:0471"|imex:IM-25807-366	author score:24.61	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:5KEYjTkeq5yRVtljfC6vv+3qWhI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9BVW5	intact:EBI-13612615	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049472|psi-mi:"MI:0471"|imex:IM-25807-365	author score:24.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:PSG9krE6Fv7zOB3M77uS3VAbGv4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O95251	intact:EBI-13612615	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049460|psi-mi:"MI:0471"|imex:IM-25807-364	author score:23.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:PnqmyowH3qUAH088bBkJku6A9oQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q16629	intact:EBI-13612615	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049448|psi-mi:"MI:0471"|imex:IM-25807-363	author score:227.78	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:vAff4uNVmLQEeNZThEVI6WFK2QY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O15305	intact:EBI-13612615	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049436|psi-mi:"MI:0471"|imex:IM-25807-362	author score:22.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:l2zIoiTcO1mAOcwn1VghVwLjlWE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96KG9	intact:EBI-13612615	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049424|psi-mi:"MI:0471"|imex:IM-25807-361	author score:22.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:RWzLysE50aCVFIyFPh4woQOh0pI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8WWY3	intact:EBI-13612615	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049412|psi-mi:"MI:0471"|imex:IM-25807-360	author score:21.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:WQZ3nI9dA9HEROliom6B1xsvDrE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9NZV6	intact:EBI-13612615	intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049400|psi-mi:"MI:0471"|imex:IM-25807-359	author score:19.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:DR4z/+yUfitTjUy4b722w3qyTk89606	rigid:iqrei7+mnPdYSfTkZrlMHZRzh+c	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P11021	intact:EBI-13612615	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049388|psi-mi:"MI:0471"|imex:IM-25807-358	author score:19.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:bxMqh76dnUuPOBRHi0Snaaemrkk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8WWH5	intact:EBI-13612615	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049376|psi-mi:"MI:0471"|imex:IM-25807-357	author score:19.39	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:l6lAEjhXvmPQ//z78P1oj4X3vHM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P13667	intact:EBI-13612615	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049364|psi-mi:"MI:0471"|imex:IM-25807-356	author score:19.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:j6idmk26Rj6FXa1q8SypX04oJso	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q86VP1	intact:EBI-13612615	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049352|psi-mi:"MI:0471"|imex:IM-25807-355	author score:19.19	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:jafmF9aUbCHGJk4nOPDLFcN5dVg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P06733	intact:EBI-13612615	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049340|psi-mi:"MI:0471"|imex:IM-25807-354	author score:18.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:jd4SzAXtH+l538hCw+HUv07k3L8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9UHY1	intact:EBI-13612615	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049328|psi-mi:"MI:0471"|imex:IM-25807-353	author score:18.21	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:pBhMTE2jhDRezf9v9ym0yXl4a3U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q13950	intact:EBI-13612615	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049316|psi-mi:"MI:0471"|imex:IM-25807-352	author score:17.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:BvYdxsXJ+0UhdhsHEN3qZmOj6T8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O95235	intact:EBI-13612615	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049304|psi-mi:"MI:0471"|imex:IM-25807-351	author score:167.93	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:hbEcUcHZQqecMGGzM7akVFWW5yw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8N2W9	intact:EBI-13612615	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049292|imex:IM-25807-350|psi-mi:"MI:0471"	author score:16.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:N51GpAsrYEM1vU9Hl1yBE5lfCWE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O60885	intact:EBI-13612615	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049280|imex:IM-25807-349|psi-mi:"MI:0471"	author score:153.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:SHaEaI4Wv9uSH45hwZASwz096VQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96QE5	intact:EBI-13612615	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049268|imex:IM-25807-348|psi-mi:"MI:0471"	author score:15.25	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:pYGMrBfjoxzraPu9ul8AVekRu1c	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P02795	uniprotkb:P36780	intact:EBI-996616|uniprotkb:Q2HXR9|uniprotkb:Q53XT9|uniprotkb:Q14823|ensembl:ENSP00000245185	intact:EBI-13612615	psi-mi:mt2_human(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Metallothionein-2A(gene name synonym)|uniprotkb:MT2A(gene name)|psi-mi:MT2A(display_short)|uniprotkb:CES1(gene name synonym)|uniprotkb:MT2(gene name synonym)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049736|imex:IM-25807-387|psi-mi:"MI:0471"	author score:4.95	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005944.1|ensembl:ENSG00000125148(gene)|ensembl:ENST00000245185(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0036018"(cellular response to erythropoietin)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P02795|rcsb pdb:1MHU|rcsb pdb:2MHU|go:"GO:0006882"(cellular zinc ion homeostasis)|reactome:R-HSA-877300|reactome:R-HSA-5661231|dip:DIP-35232N	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3adUmT5As6Rn1isYoH+jMsFKEgU9606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:SsPEEQIxprFN6mJhBut2lI3Fn1c	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8NEZ5	intact:EBI-13612615	intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049724|imex:IM-25807-386|psi-mi:"MI:0471"	author score:4.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606	rigid:d2OQz05GQBPQ0HrWhVN/oDJHNRU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P31274	intact:EBI-13612615	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049760|imex:IM-25807-389|psi-mi:"MI:0471"	author score:41.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:58e95S685mQWn3j6m/gtRhJIxZg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P50616	intact:EBI-13612615	intact:EBI-723281|uniprotkb:Q4KMQ0|intact:EBI-28983166|ensembl:ENSP00000268957|ensembl:ENSP00000427695|uniprotkb:B2R9T0|uniprotkb:D3DTY3	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tob1_human(display_long)|uniprotkb:Transducer of erbB-2 1(gene name synonym)|uniprotkb:TOB1(gene name)|psi-mi:TOB1(display_short)|uniprotkb:TOB(gene name synonym)|uniprotkb:TROB1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049772|imex:IM-25807-390|psi-mi:"MI:0471"	author score:44.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005740.1|refseq:NP_001230806.1|refseq:NP_001230814.1|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:P50616|rcsb pdb:2D5R|rcsb pdb:2Z15|rcsb pdb:5CI8|rcsb pdb:5CI9|go:"GO:0045668"(negative regulation of osteoblast differentiation)|ensembl:ENSG00000141232(gene)|ensembl:ENST00000268957(transcript)|ensembl:ENST00000499247(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|ensembl:ENSP00000268957|ensembl:ENSP00000427695	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:kJ3wPXuioip9D7MDuFmxnXTkP9w9606	rigid:jUhlHz2HbhOEwTMPmci+Pd5+Sqg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P02538	intact:EBI-13612615	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049784|psi-mi:"MI:0471"|imex:IM-25807-391	author score:45.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:KopTJ2YFewBP6R9kfpoqY0Metzg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9Y570	intact:EBI-13612615	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049796|psi-mi:"MI:0471"|imex:IM-25807-392	author score:45.72	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:RrrUxOd+5P4vxWKPsEwnDXFpgUM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q01130	intact:EBI-13612615	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049808|psi-mi:"MI:0471"|imex:IM-25807-393	author score:45.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	rigid:PHeD5y0qDgivl7Himx7Htm+61eI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P53365	intact:EBI-13612615	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049820|psi-mi:"MI:0471"|imex:IM-25807-394	author score:45.90	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:W4nv7K/DwWwypjRS6zWH6XL1Xyk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P11474	intact:EBI-13612615	intact:EBI-372412|uniprotkb:Q14514|ensembl:ENSP00000000442|ensembl:ENSP00000384851	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:err1_human(display_long)|uniprotkb:Estrogen-related receptor alpha(gene name synonym)|uniprotkb:Estrogen receptor-like 1(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group B member 1(gene name synonym)|uniprotkb:ESRRA(gene name)|psi-mi:ESRRA(display_short)|uniprotkb:ERR1(gene name synonym)|uniprotkb:ESRL1(gene name synonym)|uniprotkb:NR3B1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049832|psi-mi:"MI:0471"|imex:IM-25807-395	author score:5.22	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004442.3|refseq:NP_001269379.1|refseq:NP_001269380.1|dip:DIP-35053N|ensembl:ENSG00000173153(gene)|ensembl:ENST00000000442(transcript)|ensembl:ENST00000405666(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001650"(fibrillar center)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0032355"(response to estradiol)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051216"(cartilage development)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR027289|interpro:IPR035500|rcsb pdb:1XB7|rcsb pdb:2PJL|rcsb pdb:3D24|rcsb pdb:3K6P|rcsb pdb:7E2E|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-8939902	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:8j6Uo6uL0aWefXFicF/Y/HSL7WI9606	rigid:ScZxEQYMEqUQMGywlTb+gn2fsmA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86XZ4	uniprotkb:P36780	intact:EBI-6164306|ensembl:ENSP00000326841|ensembl:ENSP00000447947|ensembl:ENSP00000448228|uniprotkb:A8K8G9|uniprotkb:Q9H7D4|uniprotkb:Q9H8Y7|uniprotkb:Q9H8Z8	intact:EBI-13612615	psi-mi:spas2_human(display_long)|uniprotkb:SPATS2(gene name)|psi-mi:SPATS2(display_short)|uniprotkb:SCR59(gene name synonym)|uniprotkb:SPATA10(gene name synonym)|uniprotkb:Serine-rich spermatocytes and round spermatid 59 kDa protein(gene name synonym)|uniprotkb:p59scr(gene name synonym)|uniprotkb:Nbla00526(orf name)	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049844|psi-mi:"MI:0471"|imex:IM-25807-396	author score:5.61	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123352(gene)|ensembl:ENST00000321898(transcript)|ensembl:ENST00000552918(transcript)|ensembl:ENST00000553127(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR009816(Protein of unknown function DUF1387)|refseq:NP_001280214.1|refseq:NP_001280215.1|refseq:XP_011536993.1|refseq:XP_011536992.1|refseq:NP_075559.2	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:6yU6PMUIkrqHX2k+E5+pPJZcKB49606	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rigid:0ZVGc3M4b7sR1vzpzfnz6pdLdtY	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9NYF3	intact:EBI-13612615	intact:EBI-1644252|uniprotkb:D3DQB9|uniprotkb:B2RDJ5|ensembl:ENSP00000239906|ensembl:ENSP00000403705	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fa53c_human(display_long)|uniprotkb:FAM53C(gene name)|psi-mi:FAM53C(display_short)|uniprotkb:C5orf6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049856|psi-mi:"MI:0471"|imex:IM-25807-397	author score:5.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001129119.1|refseq:NP_057689.1|ensembl:ENSG00000120709(gene)|ensembl:ENST00000239906(transcript)|ensembl:ENST00000434981(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006606"(protein import into nucleus)|interpro:IPR029356	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:DOnDTyw+f+NYBQnR1iWWlajGf9I9606	rigid:Wq01hFKFzWuV/Zp7gxDnCPgtHMA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P26641	intact:EBI-13612615	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049868|psi-mi:"MI:0471"|imex:IM-25807-398	author score:5.86	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:6teJZjO+6pU5B2gUJlMEhX7dp0I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P15514	intact:EBI-13612615	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049880|psi-mi:"MI:0471"|imex:IM-25807-399	author score:5.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rigid:HFZSDwyp9oHNP+dJgrrS1gY1y7k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q16236	intact:EBI-13612615	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049892|psi-mi:"MI:0471"|imex:IM-25807-400	author score:5.93	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:FAMQPo7OViSZbg0llDy5dOqDVmw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q07817	intact:EBI-13612615	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049904|psi-mi:"MI:0471"|imex:IM-25807-401	author score:50.97	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:o8b3RnqXCr6L19Ib/gRu3wpTEqs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9Y2S7	intact:EBI-13612615	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049916|psi-mi:"MI:0471"|imex:IM-25807-402	author score:54.98	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:tYd50AuomD/KyIAQt6Quxgehb1I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q66K74	intact:EBI-13612615	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049928|psi-mi:"MI:0471"|imex:IM-25807-403	author score:55.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:aotvpN82A5hA4UK1EeK1CrPLPXc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q8N1B4	intact:EBI-13612615	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049940|psi-mi:"MI:0471"|imex:IM-25807-404	author score:57.93	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:0AkRYcmvRICEeAC7puXe9R/DcX0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P80188	intact:EBI-13612615	intact:EBI-11911016|uniprotkb:A6NII8|uniprotkb:B4DWV4|uniprotkb:B7ZAA2|uniprotkb:P30150|uniprotkb:Q5SYV9|uniprotkb:Q5SYW0|uniprotkb:Q6FGL5|uniprotkb:Q92683|ensembl:ENSP00000277480|ensembl:ENSP00000362108	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ngal_human(display_long)|uniprotkb:Siderocalin(gene name synonym)|uniprotkb:LCN2(gene name)|psi-mi:LCN2(display_short)|uniprotkb:25 kDa alpha-2-microglobulin-related subunit of MMP-9(gene name synonym)|uniprotkb:HNL(gene name synonym)|uniprotkb:Lipocalin-2(gene name synonym)|uniprotkb:NGAL(gene name synonym)|uniprotkb:Oncogene 24p3(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049952|psi-mi:"MI:0471"|imex:IM-25807-405	author score:6.00	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005555.2|dip:DIP-29952N|ensembl:ENSG00000148346(gene)|ensembl:ENST00000277480(transcript)|ensembl:ENST00000373017(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0009635"(response to herbicide)|go:"GO:0009637"(response to blue light)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015891"(siderophore transport)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036094"(small molecule binding)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0042493"|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0097577"(sequestering of iron ion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903981"(enterobactin binding)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR003087(Neutrophil gelatinase-associated lipocalin)|interpro:IPR012674(Calycin)|interpro:IPR022272|mint:P80188|rcsb pdb:1DFV|rcsb pdb:1L6M|rcsb pdb:1NGL|rcsb pdb:1QQS|rcsb pdb:1X71|rcsb pdb:1X89|rcsb pdb:1X8U|rcsb pdb:3BY0|rcsb pdb:3CBC|rcsb pdb:3CMP|rcsb pdb:3DSZ|rcsb pdb:3DTQ|rcsb pdb:3FW4|rcsb pdb:3FW5|rcsb pdb:3HWD|rcsb pdb:3HWE|rcsb pdb:3HWF|rcsb pdb:3HWG|rcsb pdb:3I0A|rcsb pdb:3K3L|rcsb pdb:3PEC|rcsb pdb:3PED|rcsb pdb:3T1D|rcsb pdb:3TF6|rcsb pdb:3TZS|rcsb pdb:3U0D|rcsb pdb:4GH7|rcsb pdb:4IAW|rcsb pdb:4IAX|rcsb pdb:4K19|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4QAE|rcsb pdb:4ZFX|rcsb pdb:4ZHC|rcsb pdb:4ZHD|rcsb pdb:4ZHF|rcsb pdb:4ZHG|rcsb pdb:4ZHH|rcsb pdb:5JR8|rcsb pdb:5KHP|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|rcsb pdb:5KIC|rcsb pdb:5KID|rcsb pdb:5MHH|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:5NKN|rcsb pdb:6GQZ|rcsb pdb:6GR0|rcsb pdb:6QMU|rcsb pdb:6S8V|rcsb pdb:6SUA|rcsb pdb:6Z2C|rcsb pdb:6Z6Z|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-917937|rcsb pdb:6O5D	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:m5Q9A8rMP15tT8/Sdt2q/a3Xsr89606	rigid:mGCwrXMSCdPZWPI3V5epT/US+G0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9UBD5	intact:EBI-13612615	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049964|psi-mi:"MI:0471"|imex:IM-25807-406	author score:6.63	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rigid:7veFNA1FbNAjobWhosoTVYWEZ8g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O75925	intact:EBI-13612615	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049976|psi-mi:"MI:0471"|imex:IM-25807-407	author score:6.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rigid:lfoQXboKRC8vtSmx5d8rnAL2rlk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q96T23	intact:EBI-13612615	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049988|psi-mi:"MI:0471"|imex:IM-25807-408	author score:61.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:epYtdURYh1UrU3iiijkSv1LP3XY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P22736	intact:EBI-13612615	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050000|psi-mi:"MI:0471"|imex:IM-25807-409	author score:62.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:ZpOssd4FCyMwj29f4/nK1O8jX7Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q13287	intact:EBI-13612615	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050012|psi-mi:"MI:0471"|imex:IM-25807-410	author score:67.90	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:Hb3YR3/NWnD0p8MONKsGDD2oTH0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9Y244	intact:EBI-13612615	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16049748|imex:IM-25807-388|psi-mi:"MI:0471"	author score:40.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:+3Awigfk3DR/PQUstXrmMmn+AjU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P09496	intact:EBI-13612615	intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050046|psi-mi:"MI:0471"|imex:IM-25807-412	author score:7.09	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606	rigid:YSjvAGecsgvieu75ddW2y2OHZmU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q15223	intact:EBI-13612615	intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050034|psi-mi:"MI:0471"|imex:IM-25807-411	author score:7.01	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606	rigid:lPYKAw9tQxTW9GeCACMviJLGnfw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9NYY3	intact:EBI-13612615	intact:EBI-721354|uniprotkb:O60679|uniprotkb:Q96CV7|uniprotkb:Q9UE61|ensembl:ENSP00000274289	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:plk2_human(display_long)|uniprotkb:Polo-like kinase 2(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SNK(gene name synonym)|uniprotkb:Serum-inducible kinase(gene name synonym)|uniprotkb:PLK2(gene name)|psi-mi:PLK2(display_short)|uniprotkb:SNK(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050154|imex:IM-25807-421|psi-mi:"MI:0471"	author score:9.39	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-48943N|refseq:NP_006613.2|refseq:NP_001239155.1|ensembl:ENSG00000145632(gene)|ensembl:ENST00000274289(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000922"(spindle pole)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007613"(memory)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046599"(regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR036947|interpro:IPR042825|rcsb pdb:4I5M|rcsb pdb:4I5P|rcsb pdb:4I6B|rcsb pdb:4I6F|rcsb pdb:4I6H|rcsb pdb:4RS6|rcsb pdb:4XB0|reactome:R-HSA-6804115|reactome:R-HSA-9662834	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:pjEqMnSG5E6daeauZylX38gmiS09606	rigid:vwlkjB6J55V6vGp252Y2liSPrD4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q99698	intact:EBI-13612615	intact:EBI-2830208|uniprotkb:Q5T2U9|uniprotkb:O43274|uniprotkb:Q96TD8|uniprotkb:Q96TD7|uniprotkb:Q9H133|uniprotkb:Q99709|ensembl:ENSP00000374443	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:lyst_human(display_long)|uniprotkb:LYST(gene name)|psi-mi:LYST(display_short)|uniprotkb:CHS(gene name synonym)|uniprotkb:CHS1(gene name synonym)|uniprotkb:Beige homolog(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050142|psi-mi:"MI:0471"|imex:IM-25807-420	author score:9.39	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001288294.1|ensembl:ENSG00000143669(gene)|ensembl:ENST00000389793(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0007040"(lysosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032438"(melanosome organization)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043473"(pigmentation)|go:"GO:0051607"(defense response to virus)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019775|interpro:IPR023362|interpro:IPR030464|interpro:IPR036322|interpro:IPR036372|refseq:NP_000072.2	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:vO+yDuFmFJ9TEmQ7JeUpni4mguY9606	rigid:KO+VtnoscULQjanWfZt/pKFxJ5Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O43791	intact:EBI-13612615	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050130|psi-mi:"MI:0471"|imex:IM-25807-419	author score:83.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:JZU7zZJVSFZ8PMxxGeX/3VyOHHE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q14289	intact:EBI-13612615	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050118|psi-mi:"MI:0471"|imex:IM-25807-418	author score:8.98	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:EjlzE5yBJ+rG79zXloxoGIRRdtA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9P086	intact:EBI-13612615	intact:EBI-394704|uniprotkb:Q6NS89|ensembl:ENSP00000293777	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:med11_human(display_long)|uniprotkb:Mediator complex subunit 11(gene name synonym)|uniprotkb:MED11(gene name)|psi-mi:MED11(display_short)|uniprotkb:HSPC296(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050106|psi-mi:"MI:0471"|imex:IM-25807-417	author score:8.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001291929.1|refseq:NP_001001683.1|ensembl:ENSG00000161920(gene)|ensembl:ENST00000293777(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019404|mint:Q9P086|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:y7SZi5hIo5aOatJSZi98Hqt082A9606	rigid:grOT4Mgtn0ZQM/oQR1+0RTQLXE0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P12814	intact:EBI-13612615	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050094|psi-mi:"MI:0471"|imex:IM-25807-416	author score:8.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:v0vofg/h48iVxTkZjC+mRXdj4+0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:P25787	intact:EBI-13612615	intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050082|psi-mi:"MI:0471"|imex:IM-25807-415	author score:8.50	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606	rigid:uFYH+l1lyFsuEKrdm1wMbJqCOUk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9UM11	intact:EBI-13612615	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050070|psi-mi:"MI:0471"|imex:IM-25807-414	author score:8.33	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	rigid:V7o9d8YRDZ2Rw9oEet1fkmgl0Is	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:O94842	intact:EBI-13612615	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050058|psi-mi:"MI:0471"|imex:IM-25807-413	author score:7.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:txIzMfQXkSxUHSrm+LD6dzJZPU8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q12834	intact:EBI-13612615	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050166|imex:IM-25807-422|psi-mi:"MI:0471"	author score:9.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rigid:4a3mQ2H/ImIXzGEaieVDHTwDhFU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36780	uniprotkb:Q9NRL2	intact:EBI-13612615	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv09(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10621(Human papillomavirus type 9)|taxid:10621(Human papillomavirus type 9)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050178|imex:IM-25807-423|psi-mi:"MI:0471"	author score:91.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|refseq:NP_041864.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:3IUv62qLjcwlUfrpO7WI6emR5ns10621	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:vxUmA5kXEJm/9LQaUDbYHcgcbDU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9BXK5	intact:EBI-7010556|intact:MINT-95651	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050190|imex:IM-25807-424|psi-mi:"MI:0471"	author score:13.54	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:7NJk2TxrjfhmMIwbza+FG8f/c/I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P16144	intact:EBI-7010556|intact:MINT-95651	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050202|imex:IM-25807-425|psi-mi:"MI:0471"	author score:15.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:x58xgGoq9PY8Gg15MUE6ku5QDoY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P20226	intact:EBI-7010556|intact:MINT-95651	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050214|imex:IM-25807-426|psi-mi:"MI:0471"	author score:16.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:dZaHCgQ+/9gCB2of2/cyATS+nfU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O43791	intact:EBI-7010556|intact:MINT-95651	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050226|imex:IM-25807-427|psi-mi:"MI:0471"	author score:19.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:APQr5ubeNt8+pzpqjO+5wddB6ys	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q86VP1	intact:EBI-7010556|intact:MINT-95651	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050238|imex:IM-25807-428|psi-mi:"MI:0471"	author score:23.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:dqzp+ciocPH2OjDyRoDfOkm5N84	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9BRH9	intact:EBI-7010556|intact:MINT-95651	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050250|imex:IM-25807-429|psi-mi:"MI:0471"	author score:3.55	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rigid:gOu4aySW9SEH7qjGus2t+iV1h94	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q5VT06	intact:EBI-7010556|intact:MINT-95651	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050262|imex:IM-25807-430|psi-mi:"MI:0471"	author score:3.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:8J5AEGj2iOfLFf1kSY/m9vGlX7M	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q66K74	intact:EBI-7010556|intact:MINT-95651	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050274|psi-mi:"MI:0471"|imex:IM-25807-431	author score:3.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:P7PmsoTTcbNhwFCF0ihTHpGpQ4c	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9UHB9	intact:EBI-7010556|intact:MINT-95651	intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050286|psi-mi:"MI:0471"|imex:IM-25807-432	author score:3.72	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606	rigid:1hdiHcmcAHZliBP/H8hHHtyxyb4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q96JC1	intact:EBI-7010556|intact:MINT-95651	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050298|psi-mi:"MI:0471"|imex:IM-25807-433	author score:3.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:/kUk/Aw0/DMy/25pI8VzcKxsHVo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q07955	intact:EBI-7010556|intact:MINT-95651	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050310|psi-mi:"MI:0471"|imex:IM-25807-434	author score:3.82	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:RaqkLHzdgzXWactiydL6dgkT/5k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O60885	intact:EBI-7010556|intact:MINT-95651	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050322|psi-mi:"MI:0471"|imex:IM-25807-435	author score:35.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:B7cyy8rQXeRMuPvK9ghUcRI4ryA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q8NAP3	intact:EBI-7010556|intact:MINT-95651	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050334|psi-mi:"MI:0471"|imex:IM-25807-436	author score:4.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:aRUHHc1Mv1iJi28AaU9cR+Ort2M	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P53365	intact:EBI-7010556|intact:MINT-95651	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050346|psi-mi:"MI:0471"|imex:IM-25807-437	author score:4.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:AsOz/4EkcSYw2ISjtf0Ht3did8g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P02538	intact:EBI-7010556|intact:MINT-95651	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050358|psi-mi:"MI:0471"|imex:IM-25807-438	author score:4.31	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:rn7xEJKk1fy0zwxMPFAnpYye30Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q8IWI9	intact:EBI-7010556|intact:MINT-95651	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050370|psi-mi:"MI:0471"|imex:IM-25807-439	author score:4.53	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:uIZi8TkZXBGYuTgmGzf8byWNq0A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q96QF0	intact:EBI-7010556|intact:MINT-95651	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050382|psi-mi:"MI:0471"|imex:IM-25807-440	author score:4.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:OitL4YqIxw9biTG3nDfmVvxC4iQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q16236	intact:EBI-7010556|intact:MINT-95651	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050394|psi-mi:"MI:0471"|imex:IM-25807-441	author score:4.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:plZBn6AebxKOtIqQUX85l/QlkA8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q16629	intact:EBI-7010556|intact:MINT-95651	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050406|psi-mi:"MI:0471"|imex:IM-25807-442	author score:4.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:1ykppMBUZe8LuhAJXx3qkxjv3jE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q96T23	intact:EBI-7010556|intact:MINT-95651	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050418|psi-mi:"MI:0471"|imex:IM-25807-443	author score:4.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:CWKVPRDHHp6F/5zb+iHbXCuTXWI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O95251	intact:EBI-7010556|intact:MINT-95651	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050430|psi-mi:"MI:0471"|imex:IM-25807-444	author score:4.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:Sxrl8XeRh4D7QBLXITBa6yRGoZ0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q13287	intact:EBI-7010556|intact:MINT-95651	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050442|psi-mi:"MI:0471"|imex:IM-25807-445	author score:5.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:9wmGXTW8i06nK0EwWbz9setbNVE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9Y244	intact:EBI-7010556|intact:MINT-95651	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050454|psi-mi:"MI:0471"|imex:IM-25807-446	author score:5.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:HigGYo9YsNy5W/h95oieAr3nXvQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q8N1B4	intact:EBI-7010556|intact:MINT-95651	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050466|psi-mi:"MI:0471"|imex:IM-25807-447	author score:5.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:a1wrx0iSeVYbS7SmGWpz4I4r8eg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O94842	intact:EBI-7010556|intact:MINT-95651	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050490|psi-mi:"MI:0471"|imex:IM-25807-449	author score:5.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:w42XMWL9qrAPYGi4oYLUdQgKQ2k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q96KG9	intact:EBI-7010556|intact:MINT-95651	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050478|psi-mi:"MI:0471"|imex:IM-25807-448	author score:5.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:ocOdjzKs3Gex962hXl4+9yEtrAU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q96T23	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051018|psi-mi:"MI:0471"|imex:IM-25807-493	author score:6.25	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:O4saXhZfTFmHxEKZ18pACeGD9gI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q13287	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051006|psi-mi:"MI:0471"|imex:IM-25807-492	author score:6.22	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:NfpoTvZxbB0AQJTtqg1J1kh5Yvg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q8N1B4	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050994|psi-mi:"MI:0471"|imex:IM-25807-491	author score:56.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:0Pi7HsEx8CWRFPx05NNRov0GZ9U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P31274	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050982|psi-mi:"MI:0471"|imex:IM-25807-490	author score:5.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:GpaDpxHUwnD1AaPvNmB7jvoiB60	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O43791	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050970|psi-mi:"MI:0471"|imex:IM-25807-489	author score:5.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:YgtGRICc4XaFHOqH8Zo/0oPTi/U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P04637	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050958|psi-mi:"MI:0471"|imex:IM-25807-488	author score:5.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:zFTRlQBiCKzrQjkfWRTaYSHeK4Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9NRL2	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050946|psi-mi:"MI:0471"|imex:IM-25807-487	author score:5.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:/uFXqDleJXuniz8czJM65v7B7SI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q12834	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050934|psi-mi:"MI:0471"|imex:IM-25807-486	author score:5.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rigid:rAggkYytkKjZaYiaD68898hftKk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q16629	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050922|psi-mi:"MI:0471"|imex:IM-25807-485	author score:4.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:Sn8SxB9YdSEOZUQoH06vaXW22Ww	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9H0C5	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-935503|uniprotkb:A6NMI8|uniprotkb:Q9BX71|uniprotkb:Q9NWN4|ensembl:ENSP00000261721	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:btbd1_human(display_long)|uniprotkb:BTBD1(gene name)|psi-mi:BTBD1(display_short)|uniprotkb:C15orf1(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 8(gene name synonym)|uniprotkb:NS5ATP8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050910|psi-mi:"MI:0471"|imex:IM-25807-484	author score:4.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001011885.1|refseq:NP_079514.1|ensembl:ENSG00000064726(gene)|ensembl:ENST00000261721(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR012983(PHR)|interpro:IPR038648|reactome:R-HSA-8951664|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:fRSh7JVRI2O2o8m7WCEjydcX1QM9606	rigid:NGDgVY2DIjySl/IJt7tnanzBdOY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q96BJ3	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-4401674|uniprotkb:A8K1F0|uniprotkb:Q49A81|uniprotkb:Q5JRA4|uniprotkb:Q658P1|uniprotkb:Q9H9E8|ensembl:ENSP00000339161	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aida_human(display_long)|uniprotkb:AIDA(gene name)|psi-mi:AIDA(display_short)|uniprotkb:C1orf80(gene name synonym)|uniprotkb:Axin interaction partner and dorsalization antagonist(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050898|psi-mi:"MI:0471"|imex:IM-25807-483	author score:4.39	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_073742.2|ensembl:ENSG00000186063(gene)|ensembl:ENST00000340020(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0016020"(membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048264"(determination of ventral identity)|interpro:IPR023421|interpro:IPR025939|interpro:IPR035892|interpro:IPR036818	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:Eo7oyV29ug5MrDH2coUbbW68pdc9606	rigid:KDtf8vtIUktkEfKXwLQ+mFLNrjc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q96QF0	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050886|psi-mi:"MI:0471"|imex:IM-25807-482	author score:4.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:bCa/P3BGgcmFhYa49yXpA9ZukHM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q00403	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-389564|uniprotkb:A8K1A7|uniprotkb:Q5JS30|ensembl:ENSP00000359531	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tf2b_human(display_long)|uniprotkb:GTF2B(gene name)|psi-mi:GTF2B(display_short)|uniprotkb:TF2B(gene name synonym)|uniprotkb:TFIIB(gene name synonym)|uniprotkb:General transcription factor TFIIB(gene name synonym)|uniprotkb:S300-II(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050874|psi-mi:"MI:0471"|imex:IM-25807-481	author score:4.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001505.1|ensembl:ENSG00000137947(gene)|ensembl:ENST00000370500(transcript)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001174"(transcriptional start site selection at RNA polymerase II promoter)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005694"(chromosome)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006473"(protein acetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019083"(viral transcription)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1990114"(RNA polymerase II core complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000812(Transcription factor TFIIB related)|interpro:IPR013137(Zinc finger, TFIIB-type)|interpro:IPR013150(Transcription factor TFIIB, cyclin-related)|interpro:IPR013763(Cyclin-related)|interpro:IPR023486|interpro:IPR036915|mint:Q00403|rcsb pdb:1C9B|rcsb pdb:1DL6|rcsb pdb:1RLY|rcsb pdb:1RO4|rcsb pdb:1TFB|rcsb pdb:1VOL|rcsb pdb:2PHG|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5WH1|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-674695|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|dip:DIP-1077N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:mVGHi0jBibSFHpBrVTGHnRm4gXw9606	rigid:fVmZRFiSFoezUegbw3hwYrlzod0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q15365	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050862|psi-mi:"MI:0471"|imex:IM-25807-480	author score:4.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:RHKVpdWi+CehTnqFG3DnXoTCHUU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O95251	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050850|psi-mi:"MI:0471"|imex:IM-25807-479	author score:4.08	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:tv4DqPEQyJdGEMKy9kf5JozucdY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O00308	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050838|psi-mi:"MI:0471"|imex:IM-25807-478	author score:4.06	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:brjUdLcetNn2Y2KoaFOr6U1nXA0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q66K74	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050826|psi-mi:"MI:0471"|imex:IM-25807-477	author score:4.05	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:Me1fEmoQsP5fLILsIeJRyxOd0SU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P56537	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-372243|uniprotkb:Q6IBN8|uniprotkb:Q96TD5|uniprotkb:B7ZBG9|ensembl:ENSP00000363559|ensembl:ENSP00000363574|ensembl:ENSP00000502429	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:if6_human(display_long)|uniprotkb:EIF6(gene name)|psi-mi:EIF6(display_short)|uniprotkb:ITGB4BP(gene name synonym)|uniprotkb:OK/SW-cl.27(orf name)|uniprotkb:B4 integrin interactor(gene name synonym)|uniprotkb:CAB(gene name synonym)|uniprotkb:"p27(BBP)"(gene name synonym)|uniprotkb:"B(2)GCN homolog"(gene name synonym)|uniprotkb:EIF3A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050814|psi-mi:"MI:0471"|imex:IM-25807-476	author score:3.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_002203.1|refseq:NP_852131.1|refseq:NP_852133.1|refseq:NP_001254739.1|ensembl:ENSG00000242372(gene)|ensembl:ENST00000374436(transcript)|ensembl:ENST00000374450(transcript)|ensembl:ENST00000675032(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0032868"(response to insulin)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR002769(Translation initiation factor IF6)|mint:P56537|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:A0pOylQptNBlSiBKiZre7INejF49606	rigid:zZrwGphpXPLNcTPGt7J0rP7caqw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O15305	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050802|psi-mi:"MI:0471"|imex:IM-25807-475	author score:3.82	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:S40Azl6bJcUuGzetmBOxBrEVSqQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q5VT06	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050790|psi-mi:"MI:0471"|imex:IM-25807-474	author score:3.79	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:QVcoegkvuhbTdWM1HfNUPAuuwYg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P04792	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050778|psi-mi:"MI:0471"|imex:IM-25807-473	author score:3.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:+JPwBGq+HRCw3YwR5HbWtpTWH2E	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9BXK5	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050766|psi-mi:"MI:0471"|imex:IM-25807-472	author score:3.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:g9oCXPuaWxviGURIAZ6fQPShq6Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9H5V8	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1019736|uniprotkb:Q49UB4|uniprotkb:Q6NT71|uniprotkb:Q6U9Y2|uniprotkb:Q8WU91|uniprotkb:Q96QU7|uniprotkb:Q9H676|uniprotkb:Q9H8C2|ensembl:ENSP00000296129	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdcp1_human(display_long)|uniprotkb:CDCP1(gene name)|psi-mi:CDCP1(display_short)|uniprotkb:TRASK(gene name synonym)|uniprotkb:UNQ2486/PRO5773(orf name)|uniprotkb:Transmembrane and associated with src kinases(gene name synonym)|uniprotkb:Membrane glycoprotein gp140(gene name synonym)|uniprotkb:Subtractive immunization M plus HEp3-associated 135 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050754|psi-mi:"MI:0471"|imex:IM-25807-471	author score:3.64	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_073753.3|refseq:NP_835488.1|dip:DIP-33861N|ensembl:ENSG00000163814(gene)|ensembl:ENST00000296129(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR035914|interpro:IPR038811	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:sAXK+WNzP2qtJ53Fu6+cuehNA289606	rigid:Rb3hLTRpdExYm6XfpWmYGlyflMI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q96KG9	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050742|imex:IM-25807-470|psi-mi:"MI:0471"	author score:3.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:Cb9VZHPumnUBYHSu43OtseLdkhM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9UHB9	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050730|imex:IM-25807-469|psi-mi:"MI:0471"	author score:3.56	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606	rigid:cyMLTHPyAPrmfIHK/Xmj5ftplXo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P11021	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050718|imex:IM-25807-468|psi-mi:"MI:0471"	author score:3.54	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:Z4MOSZ6lB2bgBB9yztbSSDFbEy8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P22314	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050706|imex:IM-25807-467|psi-mi:"MI:0471"	author score:3.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:RqhVYW/pPg6pPRbtdGcinGBwioE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q86VP1	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050694|imex:IM-25807-466|psi-mi:"MI:0471"	author score:21.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:0/ioMgYX0e21hi5WzTxBds3Cp6M	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P16144	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050682|imex:IM-25807-465|psi-mi:"MI:0471"	author score:15.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:HFCqIYs1AmOZtjdtQpTukz5uocU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P53365	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050670|imex:IM-25807-464|psi-mi:"MI:0471"	author score:12.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:8F9HCdJJhwIyz0LBECftnYxDrSI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q14790	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050658|imex:IM-25807-463|psi-mi:"MI:0471"	author score:11.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:OSh+R1FsTmnueFEjahrNIwXP1Bc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9Y570	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050646|imex:IM-25807-462|psi-mi:"MI:0471"	author score:11.27	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:sF2E+uajutDOiyDkGVq864iZ/no	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q07955	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050634|imex:IM-25807-461|psi-mi:"MI:0471"	author score:10.66	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:k4MZZeY8v6aXHhCOdWp9FWHzoIk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q13227	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050622|psi-mi:"MI:0471"|imex:IM-25807-460	author score:10.08	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:mY5TwUWu38TrwvYTpsWrMM+IJqk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9H5V8	intact:EBI-7010556|intact:MINT-95651	intact:EBI-1019736|uniprotkb:Q49UB4|uniprotkb:Q6NT71|uniprotkb:Q6U9Y2|uniprotkb:Q8WU91|uniprotkb:Q96QU7|uniprotkb:Q9H676|uniprotkb:Q9H8C2|ensembl:ENSP00000296129	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdcp1_human(display_long)|uniprotkb:CDCP1(gene name)|psi-mi:CDCP1(display_short)|uniprotkb:TRASK(gene name synonym)|uniprotkb:UNQ2486/PRO5773(orf name)|uniprotkb:Transmembrane and associated with src kinases(gene name synonym)|uniprotkb:Membrane glycoprotein gp140(gene name synonym)|uniprotkb:Subtractive immunization M plus HEp3-associated 135 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050610|psi-mi:"MI:0471"|imex:IM-25807-459	author score:8.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_073753.3|refseq:NP_835488.1|dip:DIP-33861N|ensembl:ENSG00000163814(gene)|ensembl:ENST00000296129(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR035914|interpro:IPR038811	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:sAXK+WNzP2qtJ53Fu6+cuehNA289606	rigid:zLoYvKfP2aIXSYX29jMNyP72FUY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:O14735	intact:EBI-7010556|intact:MINT-95651	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050598|psi-mi:"MI:0471"|imex:IM-25807-458	author score:8.42	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:qUJCIGrZFcXaiQoeeaatJaUe8oE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9Y2S7	intact:EBI-7010556|intact:MINT-95651	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050586|psi-mi:"MI:0471"|imex:IM-25807-457	author score:7.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:U9CdsJsTXSIQD7pIH6J+0iYcet0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P04637	intact:EBI-7010556|intact:MINT-95651	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050574|psi-mi:"MI:0471"|imex:IM-25807-456	author score:7.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:JUmGVTdMvLiWpoJS8kb2+aUlRMQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q07817	intact:EBI-7010556|intact:MINT-95651	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050562|psi-mi:"MI:0471"|imex:IM-25807-455	author score:7.66	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:Zzyp/MMstE5MEr8gBP0fzwMP1nA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9Y570	intact:EBI-7010556|intact:MINT-95651	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050550|psi-mi:"MI:0471"|imex:IM-25807-454	author score:7.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:/qSIw5yYJmFNvQUvoKCWWHqJIuc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q14790	intact:EBI-7010556|intact:MINT-95651	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050538|psi-mi:"MI:0471"|imex:IM-25807-453	author score:6.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:mIpQCexy2PwsfpNeI8SNU/nxHT8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:P22736	intact:EBI-7010556|intact:MINT-95651	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050526|psi-mi:"MI:0471"|imex:IM-25807-452	author score:6.87	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:CuciciSRTdiph6Pre5W+21OgmqI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q9NRL2	intact:EBI-7010556|intact:MINT-95651	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050514|psi-mi:"MI:0471"|imex:IM-25807-451	author score:6.87	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:cbIVYVqgxQsfNF9aEi1N0gjrgwc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04015	uniprotkb:Q8WWH5	intact:EBI-7010556|intact:MINT-95651	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv11(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10580(hpv11)|taxid:10580(Human papillomavirus type 11)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16050502|psi-mi:"MI:0471"|imex:IM-25807-450	author score:6.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:1R6K|rcsb pdb:1R6N|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P04015|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HOBkNHD21+9IasbIqs8ViKVoyOE10580	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:HNwyoJEX0IYySOMNikYJXrW+45I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8N1B4	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051244|imex:IM-25807-510|psi-mi:"MI:0471"	author score:19.05	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:BHUsRR7luBDOKSTMVoIX6frmfcs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O14735	intact:EBI-7010629|intact:MINT-95532	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051232|imex:IM-25807-509|psi-mi:"MI:0471"	author score:18.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:vq3Gnfw50PGEb1ssSVvvFZD3vUs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O43791	intact:EBI-7010629|intact:MINT-95532	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051220|imex:IM-25807-508|psi-mi:"MI:0471"	author score:16.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:JnziuJEqUFYxSDKaLYfOyj+Wchg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P53365	intact:EBI-7010629|intact:MINT-95532	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051194|imex:IM-25807-507|psi-mi:"MI:0471"	author score:13.63	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:Dv1XcLEyGYND4jlvq/wk7n86U88	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O94842	intact:EBI-7010629|intact:MINT-95532	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051182|imex:IM-25807-506|psi-mi:"MI:0471"	author score:13.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:e+R+Hn036B3RP4PDtiB6Dwyc+D0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9Y2S7	intact:EBI-7010629|intact:MINT-95532	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051170|imex:IM-25807-505|psi-mi:"MI:0471"	author score:12.95	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:lM/BIk3O+JEN/0sMVbKjjzoNSSE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q13287	intact:EBI-7010629|intact:MINT-95532	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051158|imex:IM-25807-504|psi-mi:"MI:0471"	author score:12.82	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:/SUtlbWwHXKUCg+VThuInRsPCtg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P04637	intact:EBI-7010629|intact:MINT-95532	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051146|imex:IM-25807-503|psi-mi:"MI:0471"	author score:11.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:uBbLYGm3ZPINdvezfhzuHWxwCb8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O15305	intact:EBI-7010629|intact:MINT-95532	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051134|imex:IM-25807-502|psi-mi:"MI:0471"	author score:10.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:w2+03CTH+Cd1GptsJFOPQ32lhBA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P22736	intact:EBI-7010629|intact:MINT-95532	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051122|imex:IM-25807-501|psi-mi:"MI:0471"	author score:10.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:xJv2eguZqNc2N8XVk8rIwcbO1f0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P22736	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051110|psi-mi:"MI:0471"|imex:IM-25807-500	author score:9.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:0SazBjhjIfPkjLRL+9sCnx4wWYE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:P20226	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051098|psi-mi:"MI:0471"|imex:IM-25807-499	author score:8.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:cSWKMti5CLyfQ3TI4ZJB03Qgngs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O60885	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051084|psi-mi:"MI:0471"|imex:IM-25807-498	author score:6.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:NtNiOCyD5LQ1Cpz/GbGFpiDtakI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q8IWI9	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051067|psi-mi:"MI:0471"|imex:IM-25807-497	author score:6.88	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:Yq0hda7iy8SBZowjVE+nrhP9NXc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O95235	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051055|psi-mi:"MI:0471"|imex:IM-25807-496	author score:6.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:sMdRRcwNf0dGMTnXKs9RvihB6Wc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q9Y2S7	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051042|psi-mi:"MI:0471"|imex:IM-25807-495	author score:6.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:CFmnsJSgdg3CK0MxWrJ3jWDUvVM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:O14735	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051030|psi-mi:"MI:0471"|imex:IM-25807-494	author score:6.66	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:q9/rM4fC+0K/+5dYczJUtkn2QR4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q96QF0	intact:EBI-7010629|intact:MINT-95532	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051675|psi-mi:"MI:0471"|imex:IM-25807-533	author score:6.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:vgXpUNKOqDp1PsK12efX/WdZxxk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q07817	intact:EBI-7010629|intact:MINT-95532	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051663|psi-mi:"MI:0471"|imex:IM-25807-532	author score:6.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:N8oTzaQCIu2nC49UxRkpnBaN9YM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q96JC1	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051651|psi-mi:"MI:0471"|imex:IM-25807-531	author score:6.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:eBszsEkwjfvL5OSgghL9UemUppw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O95251	intact:EBI-7010629|intact:MINT-95532	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051639|psi-mi:"MI:0471"|imex:IM-25807-530	author score:6.13	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:35NXnRslnALZy17awGD5MjfpJtg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9BXK5	intact:EBI-7010629|intact:MINT-95532	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051627|psi-mi:"MI:0471"|imex:IM-25807-529	author score:5.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:ZLM3cwIhQvkC1sJezN1ds2ZZlBA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q14533	intact:EBI-7010629|intact:MINT-95532	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051615|psi-mi:"MI:0471"|imex:IM-25807-528	author score:5.27	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:4FIqaODV7O7Su9+jHK9Qr0DguaM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q14289	intact:EBI-7010629|intact:MINT-95532	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051603|psi-mi:"MI:0471"|imex:IM-25807-527	author score:5.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:FBlT44HAQNPtamDQ5A81j5zPgvI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q5VT06	intact:EBI-7010629|intact:MINT-95532	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051591|psi-mi:"MI:0471"|imex:IM-25807-526	author score:5.09	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:c5MIl1a+MDN7O9o5HeFCzfrKElg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P11021	intact:EBI-7010629|intact:MINT-95532	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051579|psi-mi:"MI:0471"|imex:IM-25807-525	author score:4.79	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:5Yxr52FVC5QxlnxplV3O7qyQ+X8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9Y244	intact:EBI-7010629|intact:MINT-95532	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051567|psi-mi:"MI:0471"|imex:IM-25807-524	author score:4.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:lIojxx/tIYg+JkTAx23GChSB1Xo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q96QE5	intact:EBI-7010629|intact:MINT-95532	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051555|psi-mi:"MI:0471"|imex:IM-25807-523	author score:4.39	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:cSsYGfxk9Js/MY9X8A3TzIys2J4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P26641	intact:EBI-7010629|intact:MINT-95532	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051543|psi-mi:"MI:0471"|imex:IM-25807-522	author score:4.31	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:JESONCDNmyc3v0wvUh27QyFI07E	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q07955	intact:EBI-7010629|intact:MINT-95532	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051531|psi-mi:"MI:0471"|imex:IM-25807-521	author score:4.01	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:YYxQtAd0umcEkn4mEhEeX4MZg90	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P16144	intact:EBI-7010629|intact:MINT-95532	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051519|psi-mi:"MI:0471"|imex:IM-25807-520	author score:33.27	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:W7jC4AlFr/QExORavsCApwcPpqg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8WWH5	intact:EBI-7010629|intact:MINT-95532	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051507|psi-mi:"MI:0471"|imex:IM-25807-519	author score:3.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:IVOT387n0qhyIB5OlzSwZ89E/X8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9BVW5	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051495|psi-mi:"MI:0471"|imex:IM-25807-518	author score:3.86	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:d+r1K4QoTcYU79CQoNXIXw+mPmM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8WWY3	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051483|psi-mi:"MI:0471"|imex:IM-25807-517	author score:3.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:FSND7UfkyIKmT1cHdDJlgndR8ow	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8IWI9	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051471|psi-mi:"MI:0471"|imex:IM-25807-516	author score:3.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:30Aow4i1ageXYMDSn5WxX9cillI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9UHY1	intact:EBI-7010629|intact:MINT-95532	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051459|psi-mi:"MI:0471"|imex:IM-25807-515	author score:3.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:DYSgtemR9QRy0xS53WqoZbCv4sY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q8NEZ5	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051447|psi-mi:"MI:0471"|imex:IM-25807-514	author score:3.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606	rigid:T4TIZyS3suMycoUw5+I8/W+UWKg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O60885	intact:EBI-7010629|intact:MINT-95532	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051435|psi-mi:"MI:0471"|imex:IM-25807-513	author score:26.40	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:DUBIji5ypPZNS9nT3lFDeDRjIOg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q14790	intact:EBI-7010629|intact:MINT-95532	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051423|psi-mi:"MI:0471"|imex:IM-25807-512	author score:21.64	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:PKlHJFhzE+bAycgNRChG+NP5bcA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P20226	intact:EBI-7010629|intact:MINT-95532	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051411|psi-mi:"MI:0471"|imex:IM-25807-511	author score:19.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:a03bxyOqb89SB+FJHBsriHgkULg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9BXK5	intact:EBI-13613158	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052095|psi-mi:"MI:0471"|imex:IM-25807-568	author score:22.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:1lA0+c+6OHESJ41uBjIuTvqRCk4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P16144	intact:EBI-13613158	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052083|psi-mi:"MI:0471"|imex:IM-25807-567	author score:20.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:syn3wPsFExTzafRuvq0qeQ26rf0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P22736	intact:EBI-13613158	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052071|psi-mi:"MI:0471"|imex:IM-25807-566	author score:16.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:SGNN1JSn9yC1hP7d3xNsn5juDAk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O94842	intact:EBI-13613158	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052059|psi-mi:"MI:0471"|imex:IM-25807-565	author score:16.64	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:ncOc4T4uHFVwp9w1vZKxNxqDbt8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9Y570	intact:EBI-13613158	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052047|psi-mi:"MI:0471"|imex:IM-25807-564	author score:14.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:MP+U0l8Sz5Wqb8aJRGEZXEHSRTU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P04637	intact:EBI-13613158	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052035|psi-mi:"MI:0471"|imex:IM-25807-563	author score:12.83	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:9Wsu/5sLxJKvtJViup7KO6ndDhI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O15305	intact:EBI-13613158	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052023|psi-mi:"MI:0471"|imex:IM-25807-562	author score:12.81	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:riBlW6P7+6HY2qOjOt6auFUvdr4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O14735	intact:EBI-13613158	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052011|psi-mi:"MI:0471"|imex:IM-25807-561	author score:12.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:NHdogboPCRuDMHrcJnMHVolNblk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9Y2S7	intact:EBI-13613158	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051999|psi-mi:"MI:0471"|imex:IM-25807-560	author score:11.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:7FS/Zm5EB8f/3ak8IFx/0KvaZ80	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O95251	intact:EBI-13613158	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051987|psi-mi:"MI:0471"|imex:IM-25807-559	author score:10.93	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:8LWzdLdawnuQOcJqtiqyhOJlMOI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P16144	intact:EBI-15989619	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051975|psi-mi:"MI:0471"|imex:IM-25807-558	author score:7.54	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:yxe6kzfxZ3AMP3OqD3YR3RWNKVw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P20226	intact:EBI-15989619	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051963|psi-mi:"MI:0471"|imex:IM-25807-557	author score:7.16	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:30cHMgzkp3dCjAR8hGCwuazfmQ0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P04637	intact:EBI-15989619	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051951|psi-mi:"MI:0471"|imex:IM-25807-556	author score:6.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:xf8zT5tFIhaPlszzZVaB1E+xzOA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:O43791	intact:EBI-15989619	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051939|psi-mi:"MI:0471"|imex:IM-25807-555	author score:57.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:ful7+kxAKDj1lXEJ86hv0Cn+6xw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q16236	intact:EBI-15989619	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051927|psi-mi:"MI:0471"|imex:IM-25807-554	author score:4.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:6nNvkwKiKXN1EKLXQ+0e/gIcNmg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:P22736	intact:EBI-15989619	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051915|psi-mi:"MI:0471"|imex:IM-25807-553	author score:4.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:/PmDMZPt/foYjOD6qapG7IU/EcM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q8N1B4	intact:EBI-15989619	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051903|psi-mi:"MI:0471"|imex:IM-25807-552	author score:4.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:JGAibz6O3WomFdBE55t9IxDlwuI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q16629	intact:EBI-15989619	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051891|psi-mi:"MI:0471"|imex:IM-25807-551	author score:3.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:hs2kuzFdSaYkKhUtkxsk1HMXu8Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:O60885	intact:EBI-15989619	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051879|imex:IM-25807-550|psi-mi:"MI:0471"	author score:21.65	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:vrLzWc5AajBJ10rjXiuJyXCioZw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:Q86VP1	intact:EBI-15989619	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051867|imex:IM-25807-549|psi-mi:"MI:0471"	author score:20.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:yrkOsXjuUAees3DZ9Sed5CEf0B0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36791	uniprotkb:O14735	intact:EBI-15989619	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv32(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333763(hpv32)|taxid:333763(Human papillomavirus type 32)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051855|imex:IM-25807-548|psi-mi:"MI:0471"	author score:18.84	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|refseq:NP_041804.1|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:ZwDRWcRz8v0pJdaiYc/tSg46Q3Y333763	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:GKy9g7EzFBgLJ1RYAV0unkqTZ+Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q15365	intact:EBI-7010629|intact:MINT-95532	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051843|imex:IM-25807-547|psi-mi:"MI:0471"	author score:9.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:lR2Rs3AuxyBXF3LM/WYdhmsp5PY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O00308	intact:EBI-7010629|intact:MINT-95532	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051831|imex:IM-25807-546|psi-mi:"MI:0471"	author score:9.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:4KrCNJmLiZ72txm8fIE8UFW5Rwg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9Y570	intact:EBI-7010629|intact:MINT-95532	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051819|imex:IM-25807-545|psi-mi:"MI:0471"	author score:9.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:lHSHKePL1/dEQlcP9PndRM53QYk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q13227	intact:EBI-7010629|intact:MINT-95532	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051807|imex:IM-25807-544|psi-mi:"MI:0471"	author score:8.16	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:F9kNxZhRjJRTHwF3V0YwAG//3y8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q86VP1	intact:EBI-7010629|intact:MINT-95532	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051795|imex:IM-25807-543|psi-mi:"MI:0471"	author score:71.30	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:gCWOeflKRGXT97WaLZrFX703Q2U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q96KG9	intact:EBI-7010629|intact:MINT-95532	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051783|imex:IM-25807-542|psi-mi:"MI:0471"	author score:7.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:puCA0aelq2R1JFFZKUaDl+RxsG8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9UJY5	intact:EBI-7010629|intact:MINT-95532	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051771|imex:IM-25807-541|psi-mi:"MI:0471"	author score:7.77	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:1bAKoWPICeEiSjcUT+/1/RJdoHg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q66K74	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051759|psi-mi:"MI:0471"|imex:IM-25807-540	author score:7.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:iYX3Xo9Jvp7MbguHsE0iEhnrcWI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9NRL2	intact:EBI-7010629|intact:MINT-95532	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051747|psi-mi:"MI:0471"|imex:IM-25807-539	author score:7.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:0eDFoVB4kRfcRJ7Ji9TOLvyCZiU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q9GZP9	intact:EBI-7010629|intact:MINT-95532	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051735|psi-mi:"MI:0471"|imex:IM-25807-538	author score:7.32	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rigid:GndkZNFF+1pbmnpH1esAHL8gDow	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P04792	intact:EBI-7010629|intact:MINT-95532	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051723|psi-mi:"MI:0471"|imex:IM-25807-537	author score:7.16	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:ByIVv7++qzRCvyRMFrFDxbdiMq0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:Q96T23	intact:EBI-7010629|intact:MINT-95532	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051711|psi-mi:"MI:0471"|imex:IM-25807-536	author score:6.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:YgQgTpNiC9cerMzyPiQZ+D8eELs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:P02538	intact:EBI-7010629|intact:MINT-95532	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051699|psi-mi:"MI:0471"|imex:IM-25807-535	author score:6.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:OSEmpQ9Icd0joHZrNvXosik7snI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06790	uniprotkb:O95235	intact:EBI-7010629|intact:MINT-95532	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv18(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:333761(hpv18)|taxid:333761(Human papillomavirus type 18)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16051687|psi-mi:"MI:0471"|imex:IM-25807-534	author score:6.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|go:"GO:0044191"(host cell mitochondrial membrane)|rcsb pdb:1F9F|rcsb pdb:1JJ4|rcsb pdb:1QQH|rcsb pdb:1TUE|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|mint:P06790|interpro:IPR042503|interpro:IPR042504|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	function:"E2 regulates viral transcription and DNA replication. It binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. It can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:XIwvFJvCt9Stcel0TFSU3GGlWV8333761	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:qhyaGHk2dtfTYMKKwlXwpBw/Kmo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q13287	intact:EBI-13613158	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052455|psi-mi:"MI:0471"|imex:IM-25807-598	author score:5.81	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:Y4djp1locgJSO1TZqz2osgI/RBc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9NY93	intact:EBI-13613158	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052443|psi-mi:"MI:0471"|imex:IM-25807-597	author score:5.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:+06m17/Mhz/3Na/zwduhqLzEUvQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8NEZ5	intact:EBI-13613158	intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052431|psi-mi:"MI:0471"|imex:IM-25807-596	author score:5.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606	rigid:NukyFCh/eyw6ZxMoLbhJmgDDxz4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P11021	intact:EBI-13613158	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052419|psi-mi:"MI:0471"|imex:IM-25807-595	author score:5.42	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:KjDBvzV/lRva4+thoxNe03HCduI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q07817	intact:EBI-13613158	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052407|psi-mi:"MI:0471"|imex:IM-25807-594	author score:5.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:fFWo/faKavVBS1YS2WD1ctEh88w	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P02538	intact:EBI-13613158	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052395|psi-mi:"MI:0471"|imex:IM-25807-593	author score:5.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:tl5LqUlndI2IIpDikivhTJxta6M	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q96QF0	intact:EBI-13613158	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052383|psi-mi:"MI:0471"|imex:IM-25807-592	author score:5.21	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:Hfd6NUKl97hp+QqdGsyTE4k4wmc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q13950	intact:EBI-13613158	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052371|psi-mi:"MI:0471"|imex:IM-25807-591	author score:5.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:j7J1c4+Au7zfEugLC+H1yaInEt8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8WWY3	intact:EBI-13613158	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052359|imex:IM-25807-590|psi-mi:"MI:0471"	author score:5.19	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:dRfnkr9aL5tkrLoJuUfMnfl+qb8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q86VP1	intact:EBI-13613158	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052347|imex:IM-25807-589|psi-mi:"MI:0471"	author score:46.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:QM/253sYsHNrgu0GlovSiutDacE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8NAP3	intact:EBI-13613158	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052335|imex:IM-25807-588|psi-mi:"MI:0471"	author score:4.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:9PEcTG5zdtVOcyCBoo5+29nBmx8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q15365	intact:EBI-13613158	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052323|imex:IM-25807-587|psi-mi:"MI:0471"	author score:4.96	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:jXZgKmotE8rYNxNm6ef34LVsYs4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q96T23	intact:EBI-13613158	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052311|imex:IM-25807-586|psi-mi:"MI:0471"	author score:4.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:903d8TATdl5W8IfTfKKS+UeygAc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P53365	intact:EBI-13613158	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052299|imex:IM-25807-585|psi-mi:"MI:0471"	author score:4.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:4pLmHJs3CVHHC8Qv4o6bIvW7xDs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q16236	intact:EBI-13613158	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052287|imex:IM-25807-584|psi-mi:"MI:0471"	author score:4.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:8G4LHXCNkem5K85K13q2Ag0buh4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9UJY5	intact:EBI-13613158	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052275|imex:IM-25807-583|psi-mi:"MI:0471"	author score:4.56	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:aMlzEPJNdQ7KmpcOVrCEZvlU8fI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P26641	intact:EBI-13613158	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052263|imex:IM-25807-582|psi-mi:"MI:0471"	author score:4.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:cqC7a7mKirfYchxkoHSxZww7nAY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q07955	intact:EBI-13613158	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052251|imex:IM-25807-581|psi-mi:"MI:0471"	author score:4.17	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:RVkpd/awyok0cbQLcDJLzSjWYDU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q13813	intact:EBI-13613158	intact:EBI-351450|uniprotkb:Q13186|uniprotkb:Q15324|uniprotkb:Q16606|uniprotkb:Q59EF1|uniprotkb:Q5VXV5|uniprotkb:Q5VXV6|uniprotkb:Q7Z6M5|uniprotkb:Q9P0V0|intact:EBI-4404719|intact:EBI-28985930|ensembl:ENSP00000361816	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:sptn1_human(display_long)|uniprotkb:SPTAN1(gene name)|psi-mi:SPTAN1(display_short)|uniprotkb:SPTA2(gene name synonym)|uniprotkb:Alpha-II spectrin(gene name synonym)|uniprotkb:Fodrin alpha chain(gene name synonym)|uniprotkb:NEAS(gene name synonym)|uniprotkb:Spectrin, non-erythroid alpha subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052239|psi-mi:"MI:0471"|imex:IM-25807-580	author score:4.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001123910.1|refseq:NP_001182461.1|refseq:NP_003118.2|ensembl:ENSG00000197694(gene)|ensembl:ENST00000372731(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0008091"(spectrin)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001452(Src homology-3)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR035825|interpro:IPR036028|mint:Q13813|rcsb pdb:2FOT|rcsb pdb:3F31|rcsb pdb:3FB2|rcsb pdb:5FW9|rcsb pdb:5FWB|rcsb pdb:5FWC|rcsb pdb:6ZEH|reactome:R-HSA-264870|reactome:R-HSA-373753|reactome:R-HSA-375165|reactome:R-HSA-445095|reactome:R-HSA-5673001|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9662360|reactome:R-HSA-9662361|ensembl:ENST00000358161|ensembl:ENSP00000350882|ensembl:ENSP00000361816|ensembl:ENST00000372739|ensembl:ENSP00000361824|dip:DIP-33141N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:3d5XlsH+PSg32qNR/ZiooAJ/wH89606	rigid:k7TolJeofucW4gOr2oNSmNS6NhU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9NZV6	intact:EBI-13613158	intact:EBI-12330065|ensembl:ENSP00000355084|uniprotkb:Q96RX6|uniprotkb:Q9BTV2|uniprotkb:Q9P0B1	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:msrb1_human(display_long)|uniprotkb:MSRB1(gene name)|psi-mi:MSRB1(display_short)|uniprotkb:SEPX1(gene name synonym)|uniprotkb:Selenoprotein X(gene name synonym)|uniprotkb:HSPC270(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052227|psi-mi:"MI:0471"|imex:IM-25807-579	author score:4.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000198736(gene)|ensembl:ENST00000361871(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030091"(protein repair)|go:"GO:0033743"("peptide-methionine (R)-S-oxide reductase activity")|go:"GO:0033745"("L-methionine-(R)-S-oxide reductase activity")|go:"GO:0045087"(innate immune response)|go:"GO:0070191"(methionine-R-sulfoxide reductase activity)|interpro:IPR002579(Methionine sulphoxide reductase B)|interpro:IPR011057(Mss4-like)|rcsb pdb:3MAO|reactome:R-HSA-5676934|refseq:NP_057416.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:DR4z/+yUfitTjUy4b722w3qyTk89606	rigid:N3+cf4dPrXEDMmvGxE0wtjLhYlA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRH9	uniprotkb:P06423	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	intact:EBI-13613158	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052215|psi-mi:"MI:0471"|imex:IM-25807-578	author score:4.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rigid:4n+5UR9sj7GbwUlr2LJiB/Mkwlo	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P20226	intact:EBI-13613158	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052203|psi-mi:"MI:0471"|imex:IM-25807-577	author score:36.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:c1UHB76Uz1CfM9Ib8tyzFmeDuPc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P25787	intact:EBI-13613158	intact:EBI-603262|uniprotkb:Q9BU45|ensembl:ENSP00000223321|intact:EBI-1237095|uniprotkb:Q6ICS6	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:psa2_human(display_long)|uniprotkb:PSMA2(gene name)|psi-mi:PSMA2(display_short)|uniprotkb:PSC3(gene name synonym)|uniprotkb:Proteasome component C3(gene name synonym)|uniprotkb:Macropain subunit C3(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C3(gene name synonym)|uniprotkb:HC3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052191|psi-mi:"MI:0471"|imex:IM-25807-576	author score:3.86	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	mint:P25787|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|ensembl:ENSG00000106588(gene)|ensembl:ENST00000223321(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0009615"(response to virus)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034644|refseq:NP_002778.1|dip:DIP-29364N|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:COncAMXXqT+zAHA/nK+7dweRg9A9606	rigid:G7jdXRuHS++E+PZFu05b8RSe1/o	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q12834	intact:EBI-13613158	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052179|psi-mi:"MI:0471"|imex:IM-25807-575	author score:3.83	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rigid:6r0ifDRbX5OBz5MzNkFzJw55wBQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q14289	intact:EBI-13613158	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052167|psi-mi:"MI:0471"|imex:IM-25807-574	author score:3.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:bc5ImwLNowbHBjpYHobnomUK2/Y	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8N2W9	intact:EBI-13613158	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052155|psi-mi:"MI:0471"|imex:IM-25807-573	author score:3.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:SXgYmzsZJYewPHfrGumPAQBH2OA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O00308	intact:EBI-13613158	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052143|psi-mi:"MI:0471"|imex:IM-25807-572	author score:3.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:o/zDEmKGHIUxtIDw2ZknsVkBXQI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P56537	intact:EBI-13613158	intact:EBI-372243|uniprotkb:Q6IBN8|uniprotkb:Q96TD5|uniprotkb:B7ZBG9|ensembl:ENSP00000363559|ensembl:ENSP00000363574|ensembl:ENSP00000502429	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:if6_human(display_long)|uniprotkb:EIF6(gene name)|psi-mi:EIF6(display_short)|uniprotkb:ITGB4BP(gene name synonym)|uniprotkb:OK/SW-cl.27(orf name)|uniprotkb:B4 integrin interactor(gene name synonym)|uniprotkb:CAB(gene name synonym)|uniprotkb:"p27(BBP)"(gene name synonym)|uniprotkb:"B(2)GCN homolog"(gene name synonym)|uniprotkb:EIF3A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052131|psi-mi:"MI:0471"|imex:IM-25807-571	author score:3.56	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_002203.1|refseq:NP_852131.1|refseq:NP_852133.1|refseq:NP_001254739.1|ensembl:ENSG00000242372(gene)|ensembl:ENST00000374436(transcript)|ensembl:ENST00000374450(transcript)|ensembl:ENST00000675032(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0032868"(response to insulin)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0042304"(regulation of fatty acid biosynthetic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902626"(assembly of large subunit precursor of preribosome)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR002769(Translation initiation factor IF6)|mint:P56537|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:A0pOylQptNBlSiBKiZre7INejF49606	rigid:tGYopQZjLyEhur93YStIB/CRbO4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O43791	intact:EBI-13613158	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052119|psi-mi:"MI:0471"|imex:IM-25807-570	author score:24.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:CkXmhAfnwZ96QDhz5qZ26jupCMg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q14790	intact:EBI-13613158	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052107|psi-mi:"MI:0471"|imex:IM-25807-569	author score:23.76	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:hMZkiV8bkp8NN9KqEJV0E2Q14Ok	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:P31274	intact:EBI-13613158	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052599|psi-mi:"MI:0471"|imex:IM-25807-610	author score:7.50	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:BP9YaLJ60/z+IBC9jzPIxnZrwEs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8IWX8	intact:EBI-13613158	intact:EBI-2555370|uniprotkb:O00302|uniprotkb:Q99492|uniprotkb:Q4G0Y5|uniprotkb:Q8WU30|ensembl:ENSP00000439856	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cherp_human(display_long)|uniprotkb:DAN26(gene name synonym)|uniprotkb:SCAF6(gene name synonym)|uniprotkb:SR-related CTD-associated factor 6(gene name synonym)|uniprotkb:ERPROT 213-21(gene name synonym)|uniprotkb:CHERP(gene name)|psi-mi:CHERP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052587|psi-mi:"MI:0471"|imex:IM-25807-609	author score:7.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_006378.3|ensembl:ENSG00000085872(gene)|ensembl:ENST00000546361(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000467(D111/G-patch)|interpro:IPR006569(Regulation of nuclear pre-mRNA protein)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035967|interpro:IPR039037|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:Snifq3RgcsxZ8r9MCExHeb242Ss9606	rigid:Ry5gvam4EhVxsE+s/6BGtGMNXfI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9BVW5	intact:EBI-13613158	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052575|psi-mi:"MI:0471"|imex:IM-25807-608	author score:7.29	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:dDuhCOI/PEaFY2GOUENLpIJyhSQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9Y244	intact:EBI-13613158	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052563|psi-mi:"MI:0471"|imex:IM-25807-607	author score:7.09	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:qYhkr9sXmuAZboQnZnOeeabvp6s	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q96QE5	intact:EBI-13613158	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052551|psi-mi:"MI:0471"|imex:IM-25807-606	author score:7.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:l98mwHS/OkrWujlDXpgoTstxf5g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q9NRL2	intact:EBI-13613158	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052539|psi-mi:"MI:0471"|imex:IM-25807-605	author score:6.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:MJnQC8+2v0cQ5ohb845HUT0tE6k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8WWH5	intact:EBI-13613158	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052527|psi-mi:"MI:0471"|imex:IM-25807-604	author score:6.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:M4Q9UYzAkKpVHJzDfTE6Fi1pVAk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q5VT06	intact:EBI-13613158	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052515|psi-mi:"MI:0471"|imex:IM-25807-603	author score:6.41	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:kSwLHj0BCf6vQmgJj4xn65FsCfs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q99698	intact:EBI-13613158	intact:EBI-2830208|uniprotkb:Q5T2U9|uniprotkb:O43274|uniprotkb:Q96TD8|uniprotkb:Q96TD7|uniprotkb:Q9H133|uniprotkb:Q99709|ensembl:ENSP00000374443	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:lyst_human(display_long)|uniprotkb:LYST(gene name)|psi-mi:LYST(display_short)|uniprotkb:CHS(gene name synonym)|uniprotkb:CHS1(gene name synonym)|uniprotkb:Beige homolog(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052503|psi-mi:"MI:0471"|imex:IM-25807-602	author score:6.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001288294.1|ensembl:ENSG00000143669(gene)|ensembl:ENST00000389793(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0007040"(lysosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032438"(melanosome organization)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033364"(mast cell secretory granule organization)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043473"(pigmentation)|go:"GO:0051607"(defense response to virus)|interpro:IPR000409(Beige/BEACH)|interpro:IPR001680(WD40 repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019775|interpro:IPR023362|interpro:IPR030464|interpro:IPR036322|interpro:IPR036372|refseq:NP_000072.2	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:vO+yDuFmFJ9TEmQ7JeUpni4mguY9606	rigid:LCrsPUYxYt08klJnCRWHBCXXOJE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8N1B4	intact:EBI-13613158	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052491|psi-mi:"MI:0471"|imex:IM-25807-601	author score:6.18	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:6LmhhIR5RB2fpPbg4PmXaKgKYIw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O95235	intact:EBI-13613158	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052479|psi-mi:"MI:0471"|imex:IM-25807-600	author score:6.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:nicRJqDSDvPVOo+XdtDBzzJq3Yw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q8IWI9	intact:EBI-13613158	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052467|psi-mi:"MI:0471"|imex:IM-25807-599	author score:6.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:UmrAqx8abAdBu0AuXixQrgx/HjU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q13287	intact:EBI-13615369	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052849|imex:IM-25807-630|psi-mi:"MI:0471"	author score:4.28	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:a1r1gEr7XuPKMte6QsDpbygFbtQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q13227	intact:EBI-13615369	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052837|imex:IM-25807-629|psi-mi:"MI:0471"	author score:4.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:kc3PH2CXn+NAUk3WtIvDGkHS/Bo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O43791	intact:EBI-13615369	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052825|imex:IM-25807-628|psi-mi:"MI:0471"	author score:4.08	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:rOtk2CHxMPWgJAU7PgnEUjpQlsg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q5VT06	intact:EBI-13615369	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052813|imex:IM-25807-627|psi-mi:"MI:0471"	author score:4.00	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:+lkYVlkoNwE826QFnms2DoMiq8g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q13950	intact:EBI-13615369	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052801|imex:IM-25807-626|psi-mi:"MI:0471"	author score:3.90	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:y+mZ3UNHO2f3pgZkVmffu+lWaJA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P31274	intact:EBI-13615369	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052789|imex:IM-25807-625|psi-mi:"MI:0471"	author score:3.90	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:lg4stCZkCh28t4n9JNFV8z6HIUI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9NRL2	intact:EBI-13615369	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052777|imex:IM-25807-624|psi-mi:"MI:0471"	author score:3.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:xNxo84MEO1LrGPIWkjfL9ao4ZaI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q96QE5	intact:EBI-13615369	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052765|imex:IM-25807-623|psi-mi:"MI:0471"	author score:3.53	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:M6cBNBUVOkPxqwofaDAM00QVGrU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O60885	intact:EBI-13615369	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052753|imex:IM-25807-622|psi-mi:"MI:0471"	author score:22.97	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:nTCaoIvQxTRYnctb16UFSykSV7o	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O94842	intact:EBI-13615369	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052741|imex:IM-25807-621|psi-mi:"MI:0471"	author score:18.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:REM31rIOzWtshVIaRhx8uR1wvXo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q86VP1	intact:EBI-13615369	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052729|psi-mi:"MI:0471"|imex:IM-25807-620	author score:18.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:L3ECINUMJM8cu7ldi6kRWwOLtmE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q14790	intact:EBI-13615369	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052717|psi-mi:"MI:0471"|imex:IM-25807-619	author score:16.02	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:g+jFSNaZ7pWybmXDE8ArCRImv+M	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P16144	intact:EBI-13615369	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052705|psi-mi:"MI:0471"|imex:IM-25807-618	author score:14.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:sUOH/TTvZwzMKge8iOz1ULr3EOk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P61086	intact:EBI-13615369	intact:EBI-473850|uniprotkb:A6NJC1|uniprotkb:O54806|uniprotkb:P27924|uniprotkb:Q16721|uniprotkb:Q9CVV9|uniprotkb:Q9Y2D3|uniprotkb:B2RDF8|uniprotkb:A8K5Y9|uniprotkb:C9JGP1|ensembl:ENSP00000261427	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ube2k_human(display_long)|uniprotkb:HIP2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-25 kDa(gene name synonym)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2(gene name synonym)|uniprotkb:UBE2K(gene name)|psi-mi:UBE2K(display_short)|uniprotkb:LIG(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme K(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052693|psi-mi:"MI:0471"|imex:IM-25807-617	author score:13.78	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001104582.1|refseq:NP_001104583.1|refseq:NP_005330.1|dip:DIP-32524N|ensembl:ENSG00000078140(gene)|ensembl:ENST00000261427(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|interpro:IPR042599|rcsb pdb:1YLA|rcsb pdb:2O25|rcsb pdb:3E46|rcsb pdb:3F92|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:5DFL|rcsb pdb:6IF1|rcsb pdb:6JB6|rcsb pdb:6JB7|reactome:R-HSA-8866652|reactome:R-HSA-936440|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:TTxSiXJ5fNdGUeuzYlPvDl8W7eg9606	rigid:okalGKdlpu39eMPhRgKWtmpK2xo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P20226	intact:EBI-13615369	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052681|psi-mi:"MI:0471"|imex:IM-25807-616	author score:12.94	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:SZn0sDMJSLMVCrprDQgswt8Mn3w	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q13227	intact:EBI-13613158	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052669|psi-mi:"MI:0471"|imex:IM-25807-615	author score:9.44	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:zn73zuZyhmD5dVvz9yyjroIHCko	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q66K74	intact:EBI-13613158	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052657|psi-mi:"MI:0471"|imex:IM-25807-614	author score:8.19	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:2osUvuHaRHst4S4EFfxq3Nb45TE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:O60885	intact:EBI-13613158	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052645|psi-mi:"MI:0471"|imex:IM-25807-613	author score:71.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:1GYfDw/SnE+KSZhMbzUM9IZFpD8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06423	uniprotkb:Q16629	intact:EBI-13613158	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052633|psi-mi:"MI:0471"|imex:IM-25807-612	author score:7.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:XUqQoc+NQMdLRNWY/ulvHMVOroo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:P06423	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-13613158	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:ve2_hpv33(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10586(hpv33)|taxid:10586(Human papillomavirus type 33)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052621|psi-mi:"MI:0471"|imex:IM-25807-611	author score:7.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:HuBdT55KquPCcRV7BjZLGHipx2A10586	rigid:Y88+2vn78WbDlZMnFfOiWoNAbf4	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q01130	intact:EBI-15990288	intact:EBI-627047|uniprotkb:B3KWD5|ensembl:ENSP00000353089|ensembl:ENSP00000376276|ensembl:ENSP00000391278|ensembl:ENSP00000462425|uniprotkb:B4DN89|uniprotkb:H0YG49	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf2_human(display_long)|uniprotkb:Splicing factor SC35(gene name synonym)|uniprotkb:Splicing component, 35 kDa(gene name synonym)|uniprotkb:Protein PR264(gene name synonym)|uniprotkb:SRSF2(gene name)|psi-mi:SRSF2(display_short)|uniprotkb:SFRS2(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053257|imex:IM-25807-664|psi-mi:"MI:0471"	author score:20.50	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000161547(gene)|ensembl:ENST00000359995(transcript)|ensembl:ENST00000392485(transcript)|ensembl:ENST00000452355(transcript)|ensembl:ENST00000585202(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035061"(interchromatin granule)|go:"GO:0036002"(pre-mRNA binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034893|interpro:IPR035979|mint:Q01130|rcsb pdb:2KN4|rcsb pdb:2LEA|rcsb pdb:2LEB|rcsb pdb:2LEC|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0003723"(RNA binding)|refseq:NP_001182356.1|refseq:NP_003007.2|refseq:XP_016880431.1|dip:DIP-33836N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:/LUrJ8xa42APUsgH5ke590Kxsh89606	rigid:27s+dNIYtxaINQE6BLTmkCY+QOw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q13227	intact:EBI-15990288	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053245|imex:IM-25807-663|psi-mi:"MI:0471"	author score:19.55	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:8FDq4H0ea3rFQeUDlLtqiOxoLEY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P02538	intact:EBI-15990288	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053233|imex:IM-25807-662|psi-mi:"MI:0471"	author score:17.72	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:+XwyFcjqurW4BVv7aehOvEu4gnw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q16629	intact:EBI-15990288	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053221|imex:IM-25807-661|psi-mi:"MI:0471"	author score:168.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:jLuVRkr2tON47x0IG469BkPU3Do	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9UM11	intact:EBI-15990288	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053209|psi-mi:"MI:0471"|imex:IM-25807-660	author score:15.42	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	rigid:WifDycaQUOPM2MADRvopl5gjHY4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O95251	intact:EBI-15990288	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053197|psi-mi:"MI:0471"|imex:IM-25807-659	author score:15.36	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:TPEbUmR6X6qy4VuWr33G9ko+uSE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q14289	intact:EBI-15990288	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053185|psi-mi:"MI:0471"|imex:IM-25807-658	author score:14.44	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:sEHWyPFbqDRYA997svNAXVWRSVs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P04637	intact:EBI-15990288	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053173|psi-mi:"MI:0471"|imex:IM-25807-657	author score:14.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:Pxb52fBa2mtoHhcjWSeVTMv+vKM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P04792	intact:EBI-15990288	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053161|psi-mi:"MI:0471"|imex:IM-25807-656	author score:14.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:bIR9Cmr+RjH3zY+46TTW9sSkDWk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q86VP1	intact:EBI-15990288	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053149|psi-mi:"MI:0471"|imex:IM-25807-655	author score:138.42	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:hovj5+RuhxyoJNx0NPj4qspv6oQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q15365	intact:EBI-15990288	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053137|psi-mi:"MI:0471"|imex:IM-25807-654	author score:13.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:ecvKTFUch+IBS+aNiZc53Zmjc4s	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P11021	intact:EBI-15990288	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053125|psi-mi:"MI:0471"|imex:IM-25807-653	author score:13.25	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:mMIBQF0Vbm3rDUd7tpiNHKeeNiU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9Y244	intact:EBI-15990288	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053113|psi-mi:"MI:0471"|imex:IM-25807-652	author score:12.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:tfhoz0irHIoMp1i6BvgOiAnZiww	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9BVW5	intact:EBI-15990288	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053101|psi-mi:"MI:0471"|imex:IM-25807-651	author score:12.26	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:h1e+t+JJxEcEaqedGTfqHSnx4m4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P16144	intact:EBI-15990288	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053089|psi-mi:"MI:0471"|imex:IM-25807-650	author score:104.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:Q+a2OuVoj+8MsqnYkDeaeDzluUw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q14533	intact:EBI-15990288	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053077|psi-mi:"MI:0471"|imex:IM-25807-649	author score:10.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:xKMcf5SNS1er6ID1J1JMX5R/nB0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96QE5	intact:EBI-15990288	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053065|psi-mi:"MI:0471"|imex:IM-25807-648	author score:10.47	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:NfkTMQgrWRHK/AHpdZ8ZDp7ewrU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P55209	intact:EBI-15990288	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053053|psi-mi:"MI:0471"|imex:IM-25807-647	author score:10.39	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:90O2WHWrb1fVBNKx5wCOtvAL7RE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8NAP3	intact:EBI-15990288	intact:EBI-5235984|uniprotkb:D3DNF6|intact:EBI-28968990|ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:zbt38_human(display_long)|uniprotkb:ZBTB38(gene name)|psi-mi:ZBTB38(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053041|psi-mi:"MI:0471"|imex:IM-25807-646	author score:10.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000372635|ensembl:ENSP00000406955|ensembl:ENSP00000426387|ensembl:ENSP00000490041|refseq:XP_011510913.1|refseq:XP_005247314.1|refseq:XP_005247315.1|refseq:NP_001073881.2|refseq:XP_005247318.1|refseq:XP_016861541.1|refseq:XP_016861542.1|refseq:XP_016861543.1|refseq:XP_016861544.1|refseq:XP_016861545.1|refseq:XP_016861546.1|refseq:XP_016861547.1|refseq:XP_016861548.1|refseq:XP_016861549.1|refseq:XP_016861550.1|ensembl:ENSG00000177311(gene)|ensembl:ENST00000321464(transcript)|ensembl:ENST00000441582(transcript)|ensembl:ENST00000514251(transcript)|ensembl:ENST00000637056(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0072562"(blood microparticle)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q8NAP3|rcsb pdb:6E93|rcsb pdb:6E94	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:2hYBmm9S5uBZPL4JBUvGWQaTPak9606	rigid:kqf0kwCDjtQlQ6eoRuE/T+WrzCA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P31274	intact:EBI-15990288	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053029|psi-mi:"MI:0471"|imex:IM-25807-645	author score:10.04	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:5AZbB4r9k8N5gD3Yxqe0Qm39w+U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8N1B4	intact:EBI-13615369	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053017|psi-mi:"MI:0471"|imex:IM-25807-644	author score:8.64	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:+r3h8PQLEVLgYLBMkpvXfIGCT2Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q96T23	intact:EBI-13615369	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053005|psi-mi:"MI:0471"|imex:IM-25807-643	author score:7.99	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:TBC5rBNT38f7PFfYf1Wy85GkO1E	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9BXK5	intact:EBI-13615369	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052993|psi-mi:"MI:0471"|imex:IM-25807-642	author score:7.85	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:abYShoElsOL6jbKTFMU3SxUjdhI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O14735	intact:EBI-13615369	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052981|psi-mi:"MI:0471"|imex:IM-25807-641	author score:7.84	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:k4kQGk0oqgGkVxtOe0fHEgvfJ/s	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P22736	intact:EBI-13615369	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052969|psi-mi:"MI:0471"|imex:IM-25807-640	author score:7.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:/Xr9Mh9zqXeb044V+omYYicL0tc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9Y2S7	intact:EBI-13615369	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052957|psi-mi:"MI:0471"|imex:IM-25807-639	author score:7.47	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:/tGWNVvuAn7oZnGYMBHla5/o2yw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:P04637	intact:EBI-13615369	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052945|psi-mi:"MI:0471"|imex:IM-25807-638	author score:6.61	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:1fjc6TuaaYIYmpEzHPEA8zYefCg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q66K74	intact:EBI-13615369	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052933|psi-mi:"MI:0471"|imex:IM-25807-637	author score:5.38	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:+HaxOZfkchFB3u/xxlCKHbACm7M	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q9Y570	intact:EBI-13615369	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052921|psi-mi:"MI:0471"|imex:IM-25807-636	author score:5.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:SvoRSWnEFqoYm0Or4IbduCF14V4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q16629	intact:EBI-13615369	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052909|psi-mi:"MI:0471"|imex:IM-25807-635	author score:5.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:YtFOt7RlHhEypeZqd5m81GIRgno	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O15305	intact:EBI-13615369	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052897|psi-mi:"MI:0471"|imex:IM-25807-634	author score:5.05	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:YFU4Pp34LcLdPwHs91SlocyP1P4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:P24830	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-13615369	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052885|psi-mi:"MI:0471"|imex:IM-25807-633	author score:4.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rigid:mdfeT9k4Y80b3B06LzUqhedGTX0	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:O95251	intact:EBI-13615369	intact:EBI-473199|uniprotkb:B3KN74|uniprotkb:B4DFB4|uniprotkb:B4DFE0|uniprotkb:B4DF85|uniprotkb:B4DGY4|uniprotkb:E7ER15|uniprotkb:G5E9K7|intact:EBI-10986821|ensembl:ENSP00000259021	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kat7_human(display_long)|uniprotkb:KAT7(gene name)|psi-mi:KAT7(display_short)|uniprotkb:HBO1(gene name synonym)|uniprotkb:HBOa(gene name synonym)|uniprotkb:MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2(gene name synonym)|uniprotkb:Histone acetyltransferase binding to ORC1(gene name synonym)|uniprotkb:MYST2(gene name synonym)|uniprotkb:Lysine acetyltransferase 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052873|psi-mi:"MI:0471"|imex:IM-25807-632	author score:4.80	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001186084.1|refseq:NP_001186085.1|refseq:NP_001186086.1|refseq:NP_001186087.1|refseq:NP_008998.1|dip:DIP-29697N|ensembl:ENSG00000136504(gene)|ensembl:ENST00000259021(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0036409"(histone H3-K14 acetyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043983"(histone H4-K12 acetylation)|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072708"(response to sorbitol)|go:"GO:0072710"(response to hydroxyurea)|go:"GO:0072716"(response to actinomycin D)|go:"GO:0072720"(response to dithiothreitol)|go:"GO:0072739"(response to anisomycin)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:0090734"(site of DNA damage)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR002515(Zinc finger, C2HC-type)|interpro:IPR002717(MOZ/SAS-like protein)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR036060|interpro:IPR036388|interpro:IPR040706|mint:O95251|rcsb pdb:5GK9|rcsb pdb:6MAJ|rcsb pdb:6MAK|reactome:R-HSA-3214847	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:K27pgvPEe1/+rZXYUkPfMY7PZMs9606	rigid:mq/KMlUrjFkEAJVjcZv4vCWG3l4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P24830	uniprotkb:Q8IWI9	intact:EBI-13615369	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv39(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10588(Human papillomavirus type 39)|taxid:10588(Human papillomavirus type 39)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16052861|psi-mi:"MI:0471"|imex:IM-25807-631	author score:4.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:DaymlIaU4YSkBjcxsHy9P5vqnOw10588	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:i7lsv+FBNQys6VtFX3Yxic9F9zM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q5VT06	intact:EBI-15990288	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053773|imex:IM-25807-707|psi-mi:"MI:0471"	author score:7.01	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:pSkgj9gYu8NnKqY6guoi0RZUCAU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P53365	intact:EBI-15990288	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053761|imex:IM-25807-706|psi-mi:"MI:0471"	author score:69.84	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:Yy4GyPkzNEF2XXpK/b8NkIQ26VA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O60885	intact:EBI-15990288	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053749|imex:IM-25807-705|psi-mi:"MI:0471"	author score:67.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:ljXE34Jp5xGOU7IuqPPitLizkqQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9NRL2	intact:EBI-15990288	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053737|imex:IM-25807-704|psi-mi:"MI:0471"	author score:62.95	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:NfoyFfe1k30WWRaxdJCTBtg8cgE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BRH9	uniprotkb:P03118	intact:EBI-7254491|intact:MINT-1200327|uniprotkb:Q2M219|ensembl:ENSP00000292562|ensembl:ENSP00000477765	intact:EBI-15990288	psi-mi:zn251_human(display_long)|uniprotkb:ZNF251(gene name)|psi-mi:ZNF251(display_short)	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053725|imex:IM-25807-703|psi-mi:"MI:0471"	author score:6.91	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_612376.1|ensembl:ENSG00000198169(gene)|ensembl:ENSG00000278062(gene)|ensembl:ENST00000292562(transcript)|ensembl:ENST00000612318(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	function:May be involved in transcriptional regulation|comment:mint|comment:homomint	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:Xs4Lm4PLIKYF7iOgrTGgP8GwVe89606	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rigid:1Rgb0BtFFC1qwzfGEaAVCdOJySQ	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P13667	intact:EBI-15990288	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053713|imex:IM-25807-702|psi-mi:"MI:0471"	author score:6.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:pYfseCU/SRZLRt42lWKiXRaMzmY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8WWH5	intact:EBI-15990288	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053701|imex:IM-25807-701|psi-mi:"MI:0471"	author score:6.36	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:t6PYA0mqhrEvDFitkwCHgA3Rr3A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O94842	intact:EBI-15990288	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053689|psi-mi:"MI:0471"|imex:IM-25807-700	author score:6.08	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:acp0aPQrs1vBNNKgMPJQWssDORA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q14790	intact:EBI-15990288	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053677|psi-mi:"MI:0471"|imex:IM-25807-699	author score:50.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:iNM5T6uisVVDM6opsCrXM+QXhNA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96BJ3	intact:EBI-15990288	intact:EBI-4401674|uniprotkb:A8K1F0|uniprotkb:Q49A81|uniprotkb:Q5JRA4|uniprotkb:Q658P1|uniprotkb:Q9H9E8|ensembl:ENSP00000339161	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aida_human(display_long)|uniprotkb:AIDA(gene name)|psi-mi:AIDA(display_short)|uniprotkb:C1orf80(gene name synonym)|uniprotkb:Axin interaction partner and dorsalization antagonist(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053665|psi-mi:"MI:0471"|imex:IM-25807-698	author score:5.87	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_073742.2|ensembl:ENSG00000186063(gene)|ensembl:ENST00000340020(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0016020"(membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048264"(determination of ventral identity)|interpro:IPR023421|interpro:IPR025939|interpro:IPR035892|interpro:IPR036818	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:Eo7oyV29ug5MrDH2coUbbW68pdc9606	rigid:NGzRJ2lFNQ61ZUq79rDnzf64HxU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q13950	intact:EBI-15990288	intact:EBI-976402|intact:EBI-28971669|ensembl:ENSP00000360493|ensembl:ENSP00000495497|uniprotkb:O14614|uniprotkb:O14615|uniprotkb:O95181	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:runx2_human(display_long)|uniprotkb:Oncogene AML-3(gene name synonym)|uniprotkb:Polyomavirus enhancer-binding protein 2 alpha A subunit(gene name synonym)|uniprotkb:SL3-3 enhancer factor 1 alpha A subunit(gene name synonym)|uniprotkb:SL3/AKV core-binding factor alpha A subunit(gene name synonym)|uniprotkb:Osteoblast-specific transcription factor 2(gene name synonym)|uniprotkb:Core-binding factor subunit alpha-1(gene name synonym)|uniprotkb:Acute myeloid leukemia 3 protein(gene name synonym)|uniprotkb:RUNX2(gene name)|psi-mi:RUNX2(display_short)|uniprotkb:AML3(gene name synonym)|uniprotkb:CBFA1(gene name synonym)|uniprotkb:OSF2(gene name synonym)|uniprotkb:PEBP2A(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053653|psi-mi:"MI:0471"|imex:IM-25807-697	author score:5.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENST00000359524|ensembl:ENSP00000352514|ensembl:ENST00000371432|ensembl:ENSP00000360486|ensembl:ENST00000371436|ensembl:ENSP00000360491|ensembl:ENSP00000360493|ensembl:ENSP00000495497|ensembl:ENSG00000124813(gene)|ensembl:ENST00000371438(transcript)|ensembl:ENST00000647337(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048469"(cell maturation)|go:"GO:0030278"(regulation of ossification)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000040("Acute myeloid leukemia 1 protein (AML 1)/Runt")|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013524("Acute myeloid leukemia 1 (AML 1)/Runt")|interpro:IPR013711(Runx inhibition)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035115"(embryonic forelimb morphogenesis)|interpro:IPR016554(Transcription factor, Runt-related, RUNX)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|interpro:IPR027384|mint:Q13950|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043425"(bHLH transcription factor binding)|rcsb pdb:6VG8|rcsb pdb:6VGD|rcsb pdb:6VGE|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|rcsb pdb:6VGG|reactome:R-HSA-2032785|reactome:R-HSA-8878166|reactome:R-HSA-8939246|reactome:R-HSA-8939902|reactome:R-HSA-8940973|reactome:R-HSA-8941284|reactome:R-HSA-8941326|reactome:R-HSA-8941332|reactome:R-HSA-8941333|refseq:NP_001015051.3|refseq:NP_001019801.3|dip:DIP-36707N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:aUhn8jpJsl5oS4kMBgUYdpncy6Y9606	rigid:BJW82vGLZrJEKdIG4K7VJ0R3/ZI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P15514	intact:EBI-15990288	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053641|psi-mi:"MI:0471"|imex:IM-25807-696	author score:5.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rigid:uEmP4ZY6Myzv5Y30Hely/kmd0DY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9UHY1	intact:EBI-15990288	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053629|psi-mi:"MI:0471"|imex:IM-25807-695	author score:5.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:oGd/AtCjtJ8YdCP08nc0+hoVw+U	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q12834	intact:EBI-15990288	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053617|psi-mi:"MI:0471"|imex:IM-25807-694	author score:5.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rigid:V3FDfQ4kqhMp9/ckU7w8I2PPyBU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9P086	intact:EBI-15990288	intact:EBI-394704|uniprotkb:Q6NS89|ensembl:ENSP00000293777	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:med11_human(display_long)|uniprotkb:Mediator complex subunit 11(gene name synonym)|uniprotkb:MED11(gene name)|psi-mi:MED11(display_short)|uniprotkb:HSPC296(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053605|psi-mi:"MI:0471"|imex:IM-25807-693	author score:5.37	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001291929.1|refseq:NP_001001683.1|ensembl:ENSG00000161920(gene)|ensembl:ENST00000293777(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR019404|mint:Q9P086|rcsb pdb:7EMF|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7ENJ|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-1989781|reactome:R-HSA-381340|go:"GO:0003712"(transcription coregulator activity)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:y7SZi5hIo5aOatJSZi98Hqt082A9606	rigid:CG81x4NFCxdhhUyBSBCWRi86P5k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8IWI9	intact:EBI-15990288	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053593|psi-mi:"MI:0471"|imex:IM-25807-692	author score:44.53	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid://7l4Mx689B4wKbk8eeCQHiIWwU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O14735	intact:EBI-15990288	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053581|psi-mi:"MI:0471"|imex:IM-25807-691	author score:42.50	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:MHRD8nS/2WIFK6llSZ4IZY9ACk8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8N1B4	intact:EBI-15990288	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053569|psi-mi:"MI:0471"|imex:IM-25807-690	author score:40.22	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:IHQYHQuKen8bssqviBHUscW5YGg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P50616	intact:EBI-15990288	intact:EBI-723281|uniprotkb:Q4KMQ0|intact:EBI-28983166|ensembl:ENSP00000268957|ensembl:ENSP00000427695|uniprotkb:B2R9T0|uniprotkb:D3DTY3	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tob1_human(display_long)|uniprotkb:Transducer of erbB-2 1(gene name synonym)|uniprotkb:TOB1(gene name)|psi-mi:TOB1(display_short)|uniprotkb:TOB(gene name synonym)|uniprotkb:TROB1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053557|psi-mi:"MI:0471"|imex:IM-25807-689	author score:4.74	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005740.1|refseq:NP_001230806.1|refseq:NP_001230814.1|go:"GO:0046332"(SMAD binding)|go:"GO:0060212"("negative regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|interpro:IPR002087(Anti-proliferative protein)|interpro:IPR015676(Transducer of ErbB-2)|interpro:IPR015677(Transducer of ErbB-2, 1)|interpro:IPR036054|mint:P50616|rcsb pdb:2D5R|rcsb pdb:2Z15|rcsb pdb:5CI8|rcsb pdb:5CI9|go:"GO:0045668"(negative regulation of osteoblast differentiation)|ensembl:ENSG00000141232(gene)|ensembl:ENST00000268957(transcript)|ensembl:ENST00000499247(transcript)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|ensembl:ENSP00000268957|ensembl:ENSP00000427695	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:kJ3wPXuioip9D7MDuFmxnXTkP9w9606	rigid:jQtNKTLo3w1apQ9066qQnC6YeII	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q16236	intact:EBI-15990288	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053545|psi-mi:"MI:0471"|imex:IM-25807-688	author score:4.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:QKqunvGGC7R5fo5JGF1iXVraT4A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8NEZ5	intact:EBI-15990288	intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053533|psi-mi:"MI:0471"|imex:IM-25807-687	author score:4.42	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606	rigid:81na4pWExeVs1sVBGKCJUsMq2FE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O75925	intact:EBI-15990288	intact:EBI-629434|uniprotkb:Q147X4|uniprotkb:Q99751|uniprotkb:Q9UN02|uniprotkb:B2RB67|uniprotkb:B3KSY9|ensembl:ENSP00000249636|intact:EBI-28970067|uniprotkb:C5J4B4	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias1_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein 1(gene name synonym)|uniprotkb:Gu-binding protein(gene name synonym)|uniprotkb:RNA helicase II-binding protein(gene name synonym)|uniprotkb:DEAD/H box-binding protein 1(gene name synonym)|uniprotkb:PIAS1(gene name)|psi-mi:PIAS1(display_short)|uniprotkb:DDXBP1(gene name synonym)|uniprotkb:E3 SUMO-protein transferase PIAS1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053521|psi-mi:"MI:0471"|imex:IM-25807-686	author score:4.23	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001307616.1|refseq:NP_057250.1|ensembl:ENSP00000249636|ensembl:ENST00000545237|ensembl:ENSP00000438574|ensembl:ENSG00000033800(gene)|ensembl:ENST00000249636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:0065004"(protein-DNA complex assembly)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027226|interpro:IPR036361|interpro:IPR038654|mint:O75925|go:"GO:0042127"(regulation of cell population proliferation)|rcsb pdb:1V66|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-5696395|reactome:R-HSA-877312|refseq:XP_016878177.1|dip:DIP-5970N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:SJB9TG4K6p8GSZwh0MNanj6cGt49606	rigid:pkfNEdM024UlUr6YG59MnZfO96o	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P06733	intact:EBI-15990288	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053509|psi-mi:"MI:0471"|imex:IM-25807-685	author score:4.21	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:DzStBuowLIlgh45rdZ695Mj5828	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P26641	intact:EBI-15990288	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053497|psi-mi:"MI:0471"|imex:IM-25807-684	author score:4.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:DF4yAoHftrHrq3g0dEOB+jlmCVk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P62158	intact:EBI-15990288	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053485|psi-mi:"MI:0471"|imex:IM-25807-683	author score:4.09	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rigid:6lb4dq9UQIzIeM5axrb2v/r/bqw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96T23	intact:EBI-15990288	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053473|psi-mi:"MI:0471"|imex:IM-25807-682	author score:35.57	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:JZY4+ZwNbcBpAGQlWITrlSLY5HM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q66K74	intact:EBI-15990288	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053461|psi-mi:"MI:0471"|imex:IM-25807-681	author score:30.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:G1vHcKUeW2LhhmnEv4ktrLzj+9c	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P80188	intact:EBI-15990288	intact:EBI-11911016|uniprotkb:A6NII8|uniprotkb:B4DWV4|uniprotkb:B7ZAA2|uniprotkb:P30150|uniprotkb:Q5SYV9|uniprotkb:Q5SYW0|uniprotkb:Q6FGL5|uniprotkb:Q92683|ensembl:ENSP00000277480|ensembl:ENSP00000362108	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ngal_human(display_long)|uniprotkb:Siderocalin(gene name synonym)|uniprotkb:LCN2(gene name)|psi-mi:LCN2(display_short)|uniprotkb:25 kDa alpha-2-microglobulin-related subunit of MMP-9(gene name synonym)|uniprotkb:HNL(gene name synonym)|uniprotkb:Lipocalin-2(gene name synonym)|uniprotkb:NGAL(gene name synonym)|uniprotkb:Oncogene 24p3(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053449|psi-mi:"MI:0471"|imex:IM-25807-680	author score:3.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005555.2|dip:DIP-29952N|ensembl:ENSG00000148346(gene)|ensembl:ENST00000277480(transcript)|ensembl:ENST00000373017(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0009635"(response to herbicide)|go:"GO:0009637"(response to blue light)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015891"(siderophore transport)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036094"(small molecule binding)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0042493"|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0097577"(sequestering of iron ion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903981"(enterobactin binding)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR003087(Neutrophil gelatinase-associated lipocalin)|interpro:IPR012674(Calycin)|interpro:IPR022272|mint:P80188|rcsb pdb:1DFV|rcsb pdb:1L6M|rcsb pdb:1NGL|rcsb pdb:1QQS|rcsb pdb:1X71|rcsb pdb:1X89|rcsb pdb:1X8U|rcsb pdb:3BY0|rcsb pdb:3CBC|rcsb pdb:3CMP|rcsb pdb:3DSZ|rcsb pdb:3DTQ|rcsb pdb:3FW4|rcsb pdb:3FW5|rcsb pdb:3HWD|rcsb pdb:3HWE|rcsb pdb:3HWF|rcsb pdb:3HWG|rcsb pdb:3I0A|rcsb pdb:3K3L|rcsb pdb:3PEC|rcsb pdb:3PED|rcsb pdb:3T1D|rcsb pdb:3TF6|rcsb pdb:3TZS|rcsb pdb:3U0D|rcsb pdb:4GH7|rcsb pdb:4IAW|rcsb pdb:4IAX|rcsb pdb:4K19|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4QAE|rcsb pdb:4ZFX|rcsb pdb:4ZHC|rcsb pdb:4ZHD|rcsb pdb:4ZHF|rcsb pdb:4ZHG|rcsb pdb:4ZHH|rcsb pdb:5JR8|rcsb pdb:5KHP|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|rcsb pdb:5KIC|rcsb pdb:5KID|rcsb pdb:5MHH|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:5NKN|rcsb pdb:6GQZ|rcsb pdb:6GR0|rcsb pdb:6QMU|rcsb pdb:6S8V|rcsb pdb:6SUA|rcsb pdb:6Z2C|rcsb pdb:6Z6Z|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-917937|rcsb pdb:6O5D	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:m5Q9A8rMP15tT8/Sdt2q/a3Xsr89606	rigid:Q+Ppf5kczGPZ38R+FSs4pvx3x9g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8N2W9	intact:EBI-15990288	intact:EBI-473160|uniprotkb:O75926|uniprotkb:Q96G19|uniprotkb:Q9UN16|intact:EBI-28970184|ensembl:ENSP00000262971	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pias4_human(display_long)|uniprotkb:Protein inhibitor of activated STAT protein gamma(gene name synonym)|uniprotkb:PIASy(gene name synonym)|uniprotkb:PIAS4(gene name)|psi-mi:PIAS4(display_short)|uniprotkb:PIASG(gene name synonym)|uniprotkb:Protein inhibitor of activated STAT protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase PIAS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053437|psi-mi:"MI:0471"|imex:IM-25807-679	author score:3.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000105229(gene)|ensembl:ENST00000262971(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061665"(SUMO ligase activity)|ensembl:ENSP00000262971|refseq:NP_056981.2|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1902231"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1990234"(transferase complex)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR004181(Zinc finger, MIZ-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR023321|interpro:IPR027224|interpro:IPR036361|interpro:IPR038654|reactome:R-HSA-196791|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3232142|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4615885|reactome:R-HSA-4755510|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|dip:DIP-32499N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:/1DLDSbuYFdXVUmENWJvNI7WqcQ9606	rigid:Z7VWntNEYTZZvbfO0M5naKLY9BA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9NYF3	intact:EBI-15990288	intact:EBI-1644252|uniprotkb:D3DQB9|uniprotkb:B2RDJ5|ensembl:ENSP00000239906|ensembl:ENSP00000403705	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fa53c_human(display_long)|uniprotkb:FAM53C(gene name)|psi-mi:FAM53C(display_short)|uniprotkb:C5orf6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053425|psi-mi:"MI:0471"|imex:IM-25807-678	author score:3.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001129119.1|refseq:NP_057689.1|ensembl:ENSG00000120709(gene)|ensembl:ENST00000239906(transcript)|ensembl:ENST00000434981(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006606"(protein import into nucleus)|interpro:IPR029356	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:DOnDTyw+f+NYBQnR1iWWlajGf9I9606	rigid:+WuUZM71rSTwMARevPpYYhZSQ+g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9BZF9	intact:EBI-15990288	intact:EBI-350510|uniprotkb:Q14DD3|uniprotkb:Q8N3B8|uniprotkb:Q9HCL1|uniprotkb:Q9NWC6|uniprotkb:G3XAG2|uniprotkb:Q96NH6|intact:EBI-10977773|ensembl:ENSP00000314556	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uaca_human(display_long)|uniprotkb:UACA(gene name)|psi-mi:UACA(display_short)|uniprotkb:KIAA1561(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053413|psi-mi:"MI:0471"|imex:IM-25807-677	author score:3.54	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001008225.1|refseq:NP_060473.2|dip:DIP-33117N|ensembl:ENSG00000137831(gene)|ensembl:ENST00000322954(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR030227|interpro:IPR036770|mint:Q9BZF9|reactome:R-HSA-9013407|reactome:R-HSA-9627069	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:F58VkGk2DBsUUrB+wgknUFZhJ+E9606	rigid:CZMFTIW1BmGgdBivIt8jY62nZBw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9Y570	intact:EBI-15990288	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053401|psi-mi:"MI:0471"|imex:IM-25807-676	author score:29.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:Wrg2KjAkiZHEZTfRXRdcS9EwpVg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O15305	intact:EBI-15990288	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053389|psi-mi:"MI:0471"|imex:IM-25807-675	author score:28.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:U0tdaWRsj5H05kJ7nLOA45R/HSU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9Y2S7	intact:EBI-15990288	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053377|psi-mi:"MI:0471"|imex:IM-25807-674	author score:27.79	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:+yBU8tAGVqhtoTgeBLbkeEz9Ypo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q13287	intact:EBI-15990288	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053365|psi-mi:"MI:0471"|imex:IM-25807-673	author score:26.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:QYufB/W1x+o7XwmkBfB4KDba1mg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P20226	intact:EBI-15990288	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053353|psi-mi:"MI:0471"|imex:IM-25807-672	author score:25.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:uUBi5OgyMif7YOL+flYccH5GvjE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P22736	intact:EBI-15990288	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053341|psi-mi:"MI:0471"|imex:IM-25807-671	author score:25.71	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:nsAMIvZd4KT9oBehvmT2wzRcWNw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q07817	intact:EBI-15990288	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053329|imex:IM-25807-670|psi-mi:"MI:0471"	author score:25.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:as2NUhCy2HFeqxwWGEg+1xtZWV0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O00308	intact:EBI-15990288	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053317|imex:IM-25807-669|psi-mi:"MI:0471"	author score:25.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:vHaaMl5Pxv7O8idKlCfgA8sEt+8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96JC1	intact:EBI-15990288	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053305|imex:IM-25807-668|psi-mi:"MI:0471"	author score:25.08	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:pR7cwfdBqB47FFcFy72ZWgSYsK4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O95235	intact:EBI-15990288	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053293|imex:IM-25807-667|psi-mi:"MI:0471"	author score:21.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:+43b3fE8TyV4ySipkzeRC/llAkc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96KG9	intact:EBI-15990288	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053281|imex:IM-25807-666|psi-mi:"MI:0471"	author score:21.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:ZMfBVjb8Nl+1BySKmztNxwTInqo	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q96QF0	intact:EBI-15990288	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053269|imex:IM-25807-665|psi-mi:"MI:0471"	author score:20.61	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:6BlqANwSO64taa3cf5xW0Iy6fKg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9NY93	intact:EBI-15990288	intact:EBI-372376|uniprotkb:Q9H9I8|intact:EBI-1051948|uniprotkb:Q6IAE2|uniprotkb:A4D2K9|ensembl:ENSP00000258772|uniprotkb:C9JV95	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ddx56_human(display_long)|uniprotkb:DDX56(gene name)|psi-mi:DDX56(display_short)|uniprotkb:DDX21(gene name synonym)|uniprotkb:DEAD box protein 56(gene name synonym)|uniprotkb:ATP-dependent 61 kDa nucleolar RNA helicase(gene name synonym)|uniprotkb:DEAD box protein 21(gene name synonym)|uniprotkb:NOH61(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053785|imex:IM-25807-708|psi-mi:"MI:0471"	author score:7.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_061955.1|ensembl:ENSG00000136271(gene)|ensembl:ENST00000258772(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9NY93|refseq:NP_001244118.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:Pfa1hEJ7HnBZtSO4aZ2xRixpldc9606	rigid:WeJCxlnS2+HCVHGaNdgfZVYQ50o	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9UJY5	intact:EBI-15990288	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053809|imex:IM-25807-710|psi-mi:"MI:0471"	author score:8.15	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:Aye1HGzKurmo2nRSUZ1c4Grn3aQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:P03118	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-15990288	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053797|imex:IM-25807-709|psi-mi:"MI:0471"	author score:8.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rigid:tc7ozFz657qwVYvGM5R6/RiDCSg	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q9BXK5	intact:EBI-15990288	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053891|psi-mi:"MI:0471"|imex:IM-25807-716	author score:9.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:S8LhRnMmnuUpAanbWDXzEFsDZKM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P51523	intact:EBI-15990288	intact:EBI-2849074|uniprotkb:Q9UC18|uniprotkb:Q86XU8|uniprotkb:Q3ZCV9|uniprotkb:Q9NNX7|uniprotkb:Q9UC17|uniprotkb:B2RAK5|uniprotkb:Q5D057|uniprotkb:D3DXJ1|ensembl:ENSP00000331465|ensembl:ENSP00000376133|ensembl:ENSP00000445549	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:znf84_human(display_long)|uniprotkb:ZNF84(gene name)|psi-mi:ZNF84(display_short)|uniprotkb:Zinc finger protein HPF2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053879|psi-mi:"MI:0471"|imex:IM-25807-715	author score:9.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:XP_011533134.1|refseq:NP_001276900.1|refseq:NP_001276901.1|refseq:NP_001120844.1|refseq:NP_003419.3|refseq:XP_005266242.1|refseq:XP_005266243.1|ensembl:ENST00000327668(transcript)|ensembl:ENST00000392319(transcript)|ensembl:ENST00000539354(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|ensembl:ENSG00000198040(gene)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:zsEc/0um2BHfMbCHJ7GFoH9Qwfo9606	rigid:YAx8hF/jzf2AdQRTZgnYuM7J/IE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:O43791	intact:EBI-15990288	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053867|psi-mi:"MI:0471"|imex:IM-25807-714	author score:9.53	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:ZasbNDrposy8Tw3q7TN7u9VaL7I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q07955	intact:EBI-15990288	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053855|psi-mi:"MI:0471"|imex:IM-25807-713	author score:82.18	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:+zhCg8vf5V9AkQvHuF0KbgUMFCE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:Q8WWY3	intact:EBI-15990288	intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053843|psi-mi:"MI:0471"|imex:IM-25807-712	author score:8.60	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606	rigid:sRQqU/UYBx3ZE4DpqiJveCLakhs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03118	uniprotkb:P22314	intact:EBI-15990288	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10583(hpv1a)|taxid:10583(Human papillomavirus type 1a)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053831|psi-mi:"MI:0471"|imex:IM-25807-711	author score:8.47	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:M/Ev7CYGAx8JsdXfGhoH1C4eBI010583	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:TPvvBGr2sMlX3THY2PBSscthzJI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P22314	intact:EBI-15990239	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054311|psi-mi:"MI:0471"|imex:IM-25807-751	author score:4.73	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	rigid:wXeiZdzKG+LbYLONCn3fL6pLdfU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P11021	intact:EBI-15990239	intact:EBI-354921|ensembl:ENSP00000324173|uniprotkb:Q2EF78|uniprotkb:Q9NPF1|uniprotkb:Q9UK02|uniprotkb:B0QZ61	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:bip_human(display_long)|uniprotkb:HSPA5(gene name)|psi-mi:HSPA5(display_short)|uniprotkb:GRP78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054299|imex:IM-25807-750|psi-mi:"MI:0471"	author score:4.67	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000044574(gene)|ensembl:ENST00000324460(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006983"(ER overload response)|refseq:NP_005338.1|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042470"(melanosome)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0060904"(regulation of protein folding in endoplasmic reticulum)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903891"(regulation of ATF6-mediated unfolded protein response)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1903897"(regulation of PERK-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P11021|rcsb pdb:3IUC|rcsb pdb:3LDL|rcsb pdb:3LDN|rcsb pdb:3LDO|rcsb pdb:3LDP|rcsb pdb:5E84|rcsb pdb:5E85|rcsb pdb:5E86|rcsb pdb:5EVZ|rcsb pdb:5EX5|rcsb pdb:5EXW|rcsb pdb:5EY4|rcsb pdb:5F0X|rcsb pdb:5F1X|rcsb pdb:5F2R|rcsb pdb:6ASY|rcsb pdb:6CZ1|rcsb pdb:6DFM|rcsb pdb:6DFO|rcsb pdb:6DO2|rcsb pdb:6DWS|rcsb pdb:6ZMD|reactome:R-HSA-114608|reactome:R-HSA-3371453|reactome:R-HSA-381033|reactome:R-HSA-381042|reactome:R-HSA-381070|reactome:R-HSA-381183|reactome:R-HSA-983170|dip:DIP-33189N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:O8nTjCciNhD3QsbZmbolQ1IIMn49606	rigid:ih7F65FA47CAr+e+5Fkv+/xZH/Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96QE5	intact:EBI-15990239	intact:EBI-725550|uniprotkb:Q6GPG5|uniprotkb:Q6PJ19|uniprotkb:Q96H04|uniprotkb:Q9H5Z9|uniprotkb:E1P655|ensembl:ENSP00000462963	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tefm_human(display_long)|uniprotkb:TEFM(gene name)|psi-mi:TEFM(display_short)|uniprotkb:C17orf42(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054287|imex:IM-25807-749|psi-mi:"MI:0471"	author score:4.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_078959.3|ensembl:ENSG00000172171(gene)|ensembl:ENST00000581216(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006390"(mitochondrial transcription)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006392"(transcription elongation from mitochondrial promoter)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR036397|interpro:IPR039150|rcsb pdb:5OL8|rcsb pdb:5OL9|rcsb pdb:5OLA	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:J9SC0xwD2Y12yxNOohh3XyWkMu89606	rigid:OH39hxIzIUaU/AW0FDFscoxuMWg	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q5VT06	intact:EBI-15990239	intact:EBI-947346|uniprotkb:O75068|uniprotkb:Q8TDK3|uniprotkb:Q8WY20|ensembl:ENSP00000356579	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ce350_human(display_long)|uniprotkb:CEP350(gene name)|psi-mi:CEP350(display_short)|uniprotkb:CAP350(gene name synonym)|uniprotkb:GM133(orf name)|uniprotkb:KIAA0480(gene name synonym)|uniprotkb:Centrosome-associated protein of 350 kDa(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054275|imex:IM-25807-748|psi-mi:"MI:0471"	author score:4.43	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055625.4|dip:DIP-49946N|ensembl:ENSG00000135837(gene)|ensembl:ENST00000367607(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0042995"(cell projection)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR025486|interpro:IPR028750|interpro:IPR036859|rcsb pdb:2COZ	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:lwAOfFoQPaS6NHQ1NkmFWBfVA3s9606	rigid:3FTVnKS3hjcuqW45RCBzGn+YXqw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96KG9	intact:EBI-15990239	intact:EBI-949287|intact:EBI-28972634|ensembl:ENSP00000270176|uniprotkb:A6NJF1|uniprotkb:Q96G50|uniprotkb:Q96KG8|uniprotkb:Q96KH1|uniprotkb:Q9HAW5|uniprotkb:Q9HBL3|uniprotkb:Q9NR53	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:scyl1_human(display_long)|uniprotkb:SCY1-like protein 1(gene name synonym)|uniprotkb:Teratoma-associated tyrosine kinase(gene name synonym)|uniprotkb:Telomerase transcriptional element-interacting factor(gene name synonym)|uniprotkb:Telomerase regulation-associated protein(gene name synonym)|uniprotkb:SCYL1(gene name)|psi-mi:SCYL1(display_short)|uniprotkb:Coated vesicle-associated kinase of 90 kDa(gene name synonym)|uniprotkb:CVAK90(gene name synonym)|uniprotkb:GKLP(gene name synonym)|uniprotkb:NTKL(gene name synonym)|uniprotkb:TAPK(gene name synonym)|uniprotkb:TEIF(gene name synonym)|uniprotkb:TRAP(gene name synonym)|uniprotkb:HT019(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054263|imex:IM-25807-747|psi-mi:"MI:0471"	author score:4.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000142186(gene)|ensembl:ENST00000270176(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0048666"(neuron development)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_001041683.1|refseq:NP_065731.3|ensembl:ENSP00000270176|ensembl:ENST00000420247|ensembl:ENSP00000408192|ensembl:ENST00000533862|ensembl:ENSP00000437254|refseq:XP_005274177.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:qHL7to7M3sjqepd3yuU1uo4Mhy49606	rigid:BFUJZxpiBOUDYFdvkr8MxRHqzsc	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P12814	intact:EBI-15990239	intact:EBI-351710|uniprotkb:Q9BTN1|uniprotkb:Q1HE25|uniprotkb:B7TY16|intact:EBI-3866221|uniprotkb:B3V8S3|uniprotkb:B4DHH3|ensembl:ENSP00000193403	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:actn1_human(display_long)|uniprotkb:ACTN1(gene name)|psi-mi:ACTN1(display_short)|uniprotkb:Alpha-actinin cytoskeletal isoform(gene name synonym)|uniprotkb:Non-muscle alpha-actinin-1(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054251|imex:IM-25807-746|psi-mi:"MI:0471"	author score:4.31	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001093.1|refseq:NP_001123477.1|refseq:NP_001123476.1|dip:DIP-33184N|ensembl:ENSG00000072110(gene)|ensembl:ENST00000193403(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0017166"(vinculin binding)|go:"GO:0030018"(Z disc)|go:"GO:0030220"(platelet formation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031143"(pseudopodium)|go:"GO:0036344"(platelet morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051271"(negative regulation of cellular component movement)|go:"GO:0051639"(actin filament network formation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR018247|interpro:IPR036872|mint:P12814|rcsb pdb:2EYI|rcsb pdb:2EYN|rcsb pdb:2N8Y|rcsb pdb:2N8Z|reactome:R-HSA-114608|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-446388|reactome:R-HSA-9013405|reactome:R-HSA-9013418|reactome:R-HSA-9035034	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:guTURyt26f1ort4NAlYyabNc+WE9606	rigid:qwwVfwQmdZW/X0q2wxTkMzycF1k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P31274	intact:EBI-15990239	intact:EBI-1779423|uniprotkb:Q9H1I0|uniprotkb:B2RCN7|ensembl:ENSP00000302836|ensembl:ENSP00000423861	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hxc9_human(display_long)|uniprotkb:HOXC9(gene name)|psi-mi:HOXC9(display_short)|uniprotkb:HOX3B(gene name synonym)|uniprotkb:Homeobox protein Hox-3B(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054239|imex:IM-25807-745|psi-mi:"MI:0471"	author score:4.26	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_008828.1|ensembl:ENSG00000180806(gene)|ensembl:ENST00000303450(transcript)|ensembl:ENST00000508190(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0016235"(aggresome)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR006711(Hox9 activation region)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017112(Homeobox, Hox9)|interpro:IPR017970|interpro:IPR020479|rcsb pdb:2LP0|rcsb pdb:2MSY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:lzgtm1kSHg9rIAgONAjCEdZfrXE9606	rigid:e9JYJ5JhIGoycKyHrl5HI4R+cOU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9UM11	intact:EBI-15990239	intact:EBI-724997|uniprotkb:O75869|uniprotkb:Q86U66|uniprotkb:Q96NW8|uniprotkb:Q9UI96|uniprotkb:Q9ULH8|uniprotkb:Q9UM10|uniprotkb:Q9UNQ1|uniprotkb:Q9Y2T8|intact:EBI-2558941|ensembl:ENSP00000378529	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fzr1_human(display_long)|uniprotkb:FYR(gene name synonym)|uniprotkb:FZR(gene name synonym)|uniprotkb:KIAA1242(gene name synonym)|uniprotkb:FZR1(gene name)|psi-mi:FZR1(display_short)|uniprotkb:CDH1(gene name synonym)|uniprotkb:Cdh1/Hct1 homolog(gene name synonym)|uniprotkb:CDC20-like protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054227|imex:IM-25807-744|psi-mi:"MI:0471"	author score:4.21	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001129669.1|refseq:NP_001129670.1|refseq:NP_057347.2|ensembl:ENSG00000105325(gene)|ensembl:ENST00000395095(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q9UM11|rcsb pdb:4UI9|rcsb pdb:5L9T|rcsb pdb:5L9U|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174178|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176417|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-69656|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:XP_005259630.1|dip:DIP-38700N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:ABjKu6y+1XKC9gBB/k0uV4w1sHM9606	rigid:iOX9XhWZ2SWdZaO6LAsyXxqyzzU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P06733	intact:EBI-15990239	intact:EBI-353877|uniprotkb:P22712|uniprotkb:Q16704|uniprotkb:Q4TUS4|uniprotkb:Q658M5|uniprotkb:Q6GMP2|uniprotkb:Q71V37|uniprotkb:Q7Z3V6|uniprotkb:Q8WU71|uniprotkb:Q96GV1|uniprotkb:Q9BT62|uniprotkb:Q9UM55|ensembl:ENSP00000234590|uniprotkb:B2RD59|uniprotkb:Q53FT9|uniprotkb:Q53HR3|uniprotkb:Q9UCH6	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:enoa_human(display_long)|uniprotkb:ENO1(gene name)|psi-mi:ENO1(display_short)|uniprotkb:ENO1L1(gene name synonym)|uniprotkb:MBPB1(gene name synonym)|uniprotkb:MPB1(gene name synonym)|uniprotkb:2-phospho-D-glycerate hydro-lyase(gene name synonym)|uniprotkb:Non-neural enolase(gene name synonym)|uniprotkb:Enolase 1(gene name synonym)|uniprotkb:Phosphopyruvate hydratase(gene name synonym)|uniprotkb:C-myc promoter-binding protein(gene name synonym)|uniprotkb:MBP-1(gene name synonym)|uniprotkb:MPB-1(gene name synonym)|uniprotkb:Plasminogen-binding protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054215|imex:IM-25807-743|psi-mi:"MI:0471"	author score:4.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001188412.1|refseq:NP_001419.1|ensembl:ENSG00000074800(gene)|ensembl:ENST00000234590(transcript)|go:"GO:0000015"(phosphopyruvate hydratase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003723"(RNA binding)|go:"GO:0004634"(phosphopyruvate hydratase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006096"(glycolytic process)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010756"(positive regulation of plasminogen activation)|go:"GO:0016020"(membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031430"(M band)|go:"GO:0032889"(regulation of vacuole fusion, non-autophagic)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0051020"(GTPase binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000941(Enolase)|interpro:IPR020809|interpro:IPR020810|interpro:IPR020811|interpro:IPR029017|interpro:IPR036849|mint:P06733|rcsb pdb:2PSN|rcsb pdb:3B97|rcsb pdb:5JLZ|rcsb pdb:5LAX|rcsb pdb:5NI9|rcsb pdb:5NIG|rcsb pdb:5OCK|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-9636667	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:RmP7cr55H8ylcgBOEyivwljIE+09606	rigid:NSpHY+W8KG/8i0QVPeh0L4BPc4Q	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q13227	intact:EBI-15990239	intact:EBI-713355|ensembl:ENSP00000370104|ensembl:ENSP00000379841|ensembl:ENSP00000500255|ensembl:ENSP00000500677|uniprotkb:B4DXA1|uniprotkb:Q6FHM8	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gps2_human(display_long)|uniprotkb:GPS2(gene name)|psi-mi:GPS2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054203|imex:IM-25807-742|psi-mi:"MI:0471"	author score:4.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004480.1|ensembl:ENSG00000132522(gene)|ensembl:ENSG00000288325(gene)|ensembl:ENST00000380728(transcript)|ensembl:ENST00000389167(transcript)|ensembl:ENST00000672046(transcript)|ensembl:ENST00000673265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030332"(cyclin binding)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900045"(negative regulation of protein K63-linked ubiquitination)|interpro:IPR026094|rcsb pdb:2L5G|reactome:R-HSA-1989781|reactome:R-HSA-3214815|reactome:R-HSA-9022537|go:"GO:0003713"(transcription coactivator activity)|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|dip:DIP-34427N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:zMNwbPfMT2dBTxgcwiMD92QHJtM9606	rigid:YNhLGDTz7DXtjDTmMyPcWg2USo0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O14735	intact:EBI-15990239	intact:EBI-358858|uniprotkb:Q6FGU1|uniprotkb:Q6ZN70|ensembl:ENSP00000219789|ensembl:ENSP00000454453|ensembl:ENSP00000457339|uniprotkb:B4DUV0|uniprotkb:H3BTV1	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdipt_human(display_long)|uniprotkb:CDIPT(gene name)|psi-mi:CDIPT(display_short)|uniprotkb:PIS(gene name synonym)|uniprotkb:PIS1(gene name synonym)|uniprotkb:Phosphatidylinositol synthase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054191|imex:IM-25807-741|psi-mi:"MI:0471"	author score:39.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001273514.1|refseq:NP_006310.1|ensembl:ENSG00000103502(gene)|ensembl:ENST00000219789(transcript)|ensembl:ENST00000569956(transcript)|ensembl:ENST00000570016(transcript)|go:"GO:0003881"(CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0043178"(alcohol binding)|go:"GO:0046341"(CDP-diacylglycerol metabolic process)|interpro:IPR000462(CDP-alcohol phosphatidyltransferase)|interpro:IPR014387(CDP-diacylglycerol-inositol 3-phosphatidyltransferase, eukaryote)|interpro:IPR043130|reactome:R-HSA-1483226|dip:DIP-54492N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:SIs1nKd3UxZREA2Sxl4MxxBNYvM9606	rigid:pQn4WjVJutD/4/zXeG6B1frtMUM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q13287	intact:EBI-15990239	intact:EBI-372942|uniprotkb:Q53TI8|intact:EBI-10174268|uniprotkb:Q8WTW2|uniprotkb:Q9BVE5|uniprotkb:B5BU69|ensembl:ENSP00000243346	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nmi_human(display_long)|uniprotkb:NMI(gene name)|psi-mi:NMI(display_short)|uniprotkb:N-myc and STAT interactor(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054179|psi-mi:"MI:0471"|imex:IM-25807-740	author score:37.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004679.2|refseq:XP_005246998.1|ensembl:ENSG00000123609(gene)|ensembl:ENST00000243346(transcript)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|interpro:IPR009909(Nmi/IFP 35)|interpro:IPR009938(Interferon-induced 35 kDa, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033527|mint:Q13287|refseq:XP_016860736.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:qOkzIuloaWW88apb9JH2DT/Bnuk9606	rigid:Ok1LYnqY7BiLhiDwYhpBcVI2lYY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O43791	intact:EBI-15990239	intact:EBI-743549|uniprotkb:Q53HJ1|uniprotkb:B2R6S3|uniprotkb:D3DTW7|ensembl:ENSP00000240327|ensembl:ENSP00000377001|ensembl:ENSP00000420908|ensembl:ENSP00000424119|ensembl:ENSP00000425905|ensembl:ENSP00000426986|ensembl:ENSP00000499562	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:spop_human(display_long)|uniprotkb:HIB homolog 1(gene name synonym)|uniprotkb:Roadkill homolog 1(gene name synonym)|uniprotkb:SPOP(gene name)|psi-mi:SPOP(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054167|psi-mi:"MI:0471"|imex:IM-25807-739	author score:37.18	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001007227.1|refseq:NP_001007228.1|refseq:NP_001007229.1|refseq:NP_001007230.1|refseq:NP_001007231.1|refseq:NP_003554.1|refseq:XP_005257780.1|refseq:XP_005257781.1|ensembl:ENSG00000121067(gene)|ensembl:ENST00000347630(transcript)|ensembl:ENST00000393328(transcript)|ensembl:ENST00000503676(transcript)|ensembl:ENST00000504102(transcript)|ensembl:ENST00000509079(transcript)|ensembl:ENST00000514121(transcript)|ensembl:ENST00000665825(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR034089|mint:O43791|rcsb pdb:2CR2|rcsb pdb:3HQH|rcsb pdb:3HQI|rcsb pdb:3HQL|rcsb pdb:3HQM|rcsb pdb:3HSV|rcsb pdb:3HTM|rcsb pdb:3HU6|rcsb pdb:3IVB|rcsb pdb:3IVQ|rcsb pdb:3IVV|rcsb pdb:4EOZ|rcsb pdb:4HS2|rcsb pdb:4J8Z|rcsb pdb:4O1V|rcsb pdb:6F8F|rcsb pdb:6F8G|rcsb pdb:6I41|rcsb pdb:6I5P|rcsb pdb:6I68|rcsb pdb:6I7A|rcsb pdb:7D3D|rcsb pdb:7LIN|rcsb pdb:7LIO|rcsb pdb:7LIP|rcsb pdb:7LIQ|reactome:R-HSA-5632684|go:"GO:0005634"(nucleus)|refseq:XP_016880693.1|dip:DIP-50517N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:PC9ofpvk14xwTnnqT590/YRnx/49606	rigid:6mxt7yeEuXi+3LHMlWdMwjsFeg8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96QF0	intact:EBI-15990239	intact:EBI-747844|uniprotkb:Q6PCE4|uniprotkb:Q96A24|uniprotkb:Q96QE6|uniprotkb:Q96QE7|uniprotkb:Q96QE8|uniprotkb:Q96QE9|uniprotkb:Q96QF1|uniprotkb:Q9H673|uniprotkb:B7WPJ6|ensembl:ENSP00000447300	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rab3i_human(display_long)|uniprotkb:Rabin-3(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym)|uniprotkb:RAB3IP(gene name)|psi-mi:RAB3IP(display_short)|uniprotkb:RABIN8(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054155|psi-mi:"MI:0471"|imex:IM-25807-738	author score:32.06	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001265331.1|refseq:NP_001019818.1|refseq:NP_071901.2|refseq:NP_783322.1|refseq:NP_783323.1|refseq:NP_783324.1|ensembl:ENST00000247833|ensembl:ENSP00000247833|ensembl:ENST00000362025|ensembl:ENSP00000355381|ensembl:ENST00000378815|ensembl:ENSP00000368092|ensembl:ENST00000417413|ensembl:ENSP00000436304|ensembl:ENSP00000419216|ensembl:ENSP00000447300|ensembl:ENST00000551641|ensembl:ENSP00000448773|ensembl:ENST00000552199|ensembl:ENSP00000448944|ensembl:ENST00000553099|ensembl:ENSP00000448027|ensembl:ENST00000483530|refseq:XP_016874262.1|refseq:XP_016874265.1|refseq:XP_016874266.1|ensembl:ENSG00000127328(gene)|ensembl:ENST00000550536(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|go:"GO:0097711"(ciliary basal body-plasma membrane docking)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|mint:Q96QF0|rcsb pdb:4LHX|rcsb pdb:4LHY|rcsb pdb:4LHZ|rcsb pdb:4UJ3|rcsb pdb:4UJ4|rcsb pdb:4UJ5|rcsb pdb:6F6P|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-5620922|reactome:R-HSA-8876198|dip:DIP-41703N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:F/h4kufeBER1JEgPkcwIPTar/9o9606	rigid:HWcxiI/3P+5Y6er5e5PhNtR5A4I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q8IWI9	intact:EBI-15990239	intact:EBI-2815196|uniprotkb:E7ENI0|uniprotkb:F5H7K2|uniprotkb:Q9H9N7|uniprotkb:Q9H8R3|uniprotkb:Q9Y4E9|uniprotkb:Q9UG69|intact:EBI-11143500|intact:EBI-10969960|ensembl:ENSP00000219905|uniprotkb:B9EGR5	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:mgap_human(display_long)|uniprotkb:MGA(gene name)|psi-mi:MGA(display_short)|uniprotkb:KIAA0518(gene name synonym)|uniprotkb:MAD5(gene name synonym)|uniprotkb:MAX dimerization protein 5(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054143|psi-mi:"MI:0471"|imex:IM-25807-737	author score:3.92	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001074010.2|ensembl:ENSP00000219905|ensembl:ENST00000566586|ensembl:ENSP00000456141|ensembl:ENSG00000174197(gene)|ensembl:ENST00000219905(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR018186|interpro:IPR032060|interpro:IPR036638|interpro:IPR036960|interpro:IPR037935|mint:Q8IWI9|reactome:R-HSA-8953750|refseq:NP_001157745.1|dip:DIP-57615N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/07/08	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:P4lo9EteCvikQQk5kyVkcobitLU9606	rigid:SdUo1gCGfR6HkUR9NsLHPHx0PZI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P15514	intact:EBI-15990239	intact:EBI-953674|ensembl:ENSP00000379097|uniprotkb:Q5U026	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:areg_human(display_long)|uniprotkb:Colorectum cell-derived growth factor(gene name synonym)|uniprotkb:AREG(gene name)|psi-mi:AREG(display_short)|uniprotkb:SDGF(gene name synonym)|uniprotkb:AREGB(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054131|psi-mi:"MI:0471"|imex:IM-25807-736	author score:3.89	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000109321(gene)|ensembl:ENST00000395748(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009986"(cell surface)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0060598"(dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0051591"(response to cAMP)|interpro:IPR015497(Epidermal growth factor receptor ligand)|mint:P15514|rcsb pdb:2RNL|reactome:R-HSA-1257604|reactome:R-HSA-177929|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-204005|reactome:R-HSA-212718|reactome:R-HSA-2219530|reactome:R-HSA-5638303|reactome:R-HSA-5673001|reactome:R-HSA-5694530|reactome:R-HSA-6811558|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9009391|reactome:R-HSA-9634638|refseq:NP_001648.1|dip:DIP-5766N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:qMTcDyIu2SQInZtwa5znbOrq6/c9606	rigid:NJfSdwYc9WkTtH1BcUClPlfl6AQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P80188	intact:EBI-15990239	intact:EBI-11911016|uniprotkb:A6NII8|uniprotkb:B4DWV4|uniprotkb:B7ZAA2|uniprotkb:P30150|uniprotkb:Q5SYV9|uniprotkb:Q5SYW0|uniprotkb:Q6FGL5|uniprotkb:Q92683|ensembl:ENSP00000277480|ensembl:ENSP00000362108	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ngal_human(display_long)|uniprotkb:Siderocalin(gene name synonym)|uniprotkb:LCN2(gene name)|psi-mi:LCN2(display_short)|uniprotkb:25 kDa alpha-2-microglobulin-related subunit of MMP-9(gene name synonym)|uniprotkb:HNL(gene name synonym)|uniprotkb:Lipocalin-2(gene name synonym)|uniprotkb:NGAL(gene name synonym)|uniprotkb:Oncogene 24p3(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054119|psi-mi:"MI:0471"|imex:IM-25807-735	author score:3.64	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005555.2|dip:DIP-29952N|ensembl:ENSG00000148346(gene)|ensembl:ENST00000277480(transcript)|ensembl:ENST00000373017(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006953"(acute-phase response)|go:"GO:0009635"(response to herbicide)|go:"GO:0009637"(response to blue light)|go:"GO:0010040"("response to iron(II) ion")|go:"GO:0010046"(response to mycotoxin)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015891"(siderophore transport)|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0035580"(specific granule lumen)|go:"GO:0036094"(small molecule binding)|go:"GO:0036295"(cellular response to increased oxygen levels)|go:"GO:0042493"|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090650"(cellular response to oxygen-glucose deprivation)|go:"GO:0097577"(sequestering of iron ion)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903981"(enterobactin binding)|go:"GO:1904440"(positive regulation of iron ion import across plasma membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR002345(Lipocalin)|interpro:IPR003087(Neutrophil gelatinase-associated lipocalin)|interpro:IPR012674(Calycin)|interpro:IPR022272|mint:P80188|rcsb pdb:1DFV|rcsb pdb:1L6M|rcsb pdb:1NGL|rcsb pdb:1QQS|rcsb pdb:1X71|rcsb pdb:1X89|rcsb pdb:1X8U|rcsb pdb:3BY0|rcsb pdb:3CBC|rcsb pdb:3CMP|rcsb pdb:3DSZ|rcsb pdb:3DTQ|rcsb pdb:3FW4|rcsb pdb:3FW5|rcsb pdb:3HWD|rcsb pdb:3HWE|rcsb pdb:3HWF|rcsb pdb:3HWG|rcsb pdb:3I0A|rcsb pdb:3K3L|rcsb pdb:3PEC|rcsb pdb:3PED|rcsb pdb:3T1D|rcsb pdb:3TF6|rcsb pdb:3TZS|rcsb pdb:3U0D|rcsb pdb:4GH7|rcsb pdb:4IAW|rcsb pdb:4IAX|rcsb pdb:4K19|rcsb pdb:4MVI|rcsb pdb:4MVK|rcsb pdb:4MVL|rcsb pdb:4QAE|rcsb pdb:4ZFX|rcsb pdb:4ZHC|rcsb pdb:4ZHD|rcsb pdb:4ZHF|rcsb pdb:4ZHG|rcsb pdb:4ZHH|rcsb pdb:5JR8|rcsb pdb:5KHP|go:"GO:1905956"(positive regulation of endothelial tube morphogenesis)|rcsb pdb:5KIC|rcsb pdb:5KID|rcsb pdb:5MHH|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:5NKN|rcsb pdb:6GQZ|rcsb pdb:6GR0|rcsb pdb:6QMU|rcsb pdb:6S8V|rcsb pdb:6SUA|rcsb pdb:6Z2C|rcsb pdb:6Z6Z|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-6799990|reactome:R-HSA-917937|rcsb pdb:6O5D	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:m5Q9A8rMP15tT8/Sdt2q/a3Xsr89606	rigid:KpkcrRHip7mAXAuaDbY0Z0TKzf4	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9BVW5	intact:EBI-15990239	intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054107|psi-mi:"MI:0471"|imex:IM-25807-734	author score:3.52	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606	rigid:QaOoCvpKvVhmKEcFf6O102BRBC8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q8WWH5	intact:EBI-15990239	intact:EBI-6658513|ensembl:ENSP00000298746|uniprotkb:Q53ES2|uniprotkb:B2R716	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:trub1_human(display_long)|uniprotkb:TRUB1(gene name)|psi-mi:TRUB1(display_short)|uniprotkb:PUS4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054095|psi-mi:"MI:0471"|imex:IM-25807-733	author score:3.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000165832(gene)|ensembl:ENST00000298746(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:1990481"(mRNA pseudouridine synthesis)|interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR014780(tRNA pseudouridine synthase B, N-terminal, bacterial-type)|interpro:IPR020103|refseq:NP_631908.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:gjrCu9R/KVmdnMW7pbffs6CISwI9606	rigid:gW7gAf6+ULWwC5vGabDVQDoAPbI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O94842	intact:EBI-15990239	intact:EBI-948613|ensembl:ENSP00000393080|ensembl:ENSP00000477868|intact:EBI-10965337|uniprotkb:B4DPY8|uniprotkb:E7EV69|uniprotkb:B4DSM0	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tox4_human(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:TOX4(gene name)|psi-mi:TOX4(display_short)|uniprotkb:KIAA0737(gene name synonym)|uniprotkb:C14orf92(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054083|psi-mi:"MI:0471"|imex:IM-25807-732	author score:25.11	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000092203(gene)|ensembl:ENST00000448790(transcript)|ensembl:ENST00000613569(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:O94842|refseq:NP_055643.1|refseq:NP_001290452.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:tiW0mcDNOr9TsvNLVZ+f36eiNpY9606	rigid:j1uHmCjhHahkToMQxmDKipPXpjk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P04637	intact:EBI-15990239	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054071|psi-mi:"MI:0471"|imex:IM-25807-731	author score:23.81	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rigid:Nw9kKz1WhOFjV7ov0u8ptwxlR3g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q86VP1	intact:EBI-15990239	intact:EBI-529518|uniprotkb:O60398|uniprotkb:O95770|uniprotkb:Q13311|uniprotkb:Q9BQG5|uniprotkb:Q9UI88|uniprotkb:B4DKU7|uniprotkb:E7ENV2|uniprotkb:A4D196|ensembl:ENSP00000379612	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:taxb1_human(display_long)|uniprotkb:TRAF6-binding protein(gene name synonym)|uniprotkb:TAX1BP1(gene name)|psi-mi:TAX1BP1(display_short)|uniprotkb:T6BP(gene name synonym)|uniprotkb:PRO0105(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054059|psi-mi:"MI:0471"|imex:IM-25807-730	author score:226.78	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001073333.1|refseq:NP_001193830.1|refseq:NP_001193831.1|refseq:NP_006015.4|dip:DIP-33010N|ensembl:ENSG00000106052(gene)|ensembl:ENST00000396319(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q86VP1|rcsb pdb:2M7Q|rcsb pdb:4BMJ|rcsb pdb:4NLH|rcsb pdb:4Z4K|rcsb pdb:4Z4M|rcsb pdb:5AAS|rcsb pdb:5YT6|rcsb pdb:5Z7G|reactome:R-HSA-5357905|reactome:R-HSA-936440	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:OJfD9nSzpjJ3bMbHugSDVJ9fj/E9606	rigid:zjBtkCNEmTRdMO6/9DkKwaQHfMU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P55209	intact:EBI-15990239	intact:EBI-356392|ensembl:ENSP00000376947|ensembl:ENSP00000477538|uniprotkb:B3KV44|uniprotkb:B3KNT8	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:np1l1_human(display_long)|uniprotkb:NAP1L1(gene name)|psi-mi:NAP1L1(display_short)|uniprotkb:NRP(gene name synonym)|uniprotkb:NAP-1-related protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054047|psi-mi:"MI:0471"|imex:IM-25807-729	author score:22.46	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000187109(gene)|ensembl:ENST00000393263(transcript)|ensembl:ENST00000618691(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P55209|rcsb pdb:7BP5|refseq:NP_004528.1|refseq:NP_631946.1|refseq:NP_001294853.1|refseq:XP_011536695.1|refseq:NP_001317160.1|refseq:NP_001317161.1|refseq:XP_016874827.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:PtjzXGuxpQqrIEt5cbwzsbUoze89606	rigid:mQV1jIuAt3f0Yq/jh+3R4X2rYiM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q8N1B4	intact:EBI-15990239	intact:EBI-2799833|ensembl:ENSP00000372697|ensembl:ENSP00000390831|ensembl:ENSP00000391197|ensembl:ENSP00000404016|ensembl:ENSP00000406988|ensembl:ENSP00000409952|uniprotkb:B4DNI9|uniprotkb:Q9NPT5|uniprotkb:Q8IUN6|uniprotkb:Q5JPA0|uniprotkb:Q53GR4|uniprotkb:Q5SQW1|uniprotkb:B0UZZ4|uniprotkb:A2BF38	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps52_human(display_long)|uniprotkb:SACM2L(gene name synonym)|uniprotkb:SAC2 suppressor of actin mutations 2-like protein(gene name synonym)|uniprotkb:VPS52(gene name)|psi-mi:VPS52(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054035|psi-mi:"MI:0471"|imex:IM-25807-728	author score:22.01	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000223501(gene)|ensembl:ENSG00000224455(gene)|ensembl:ENSG00000225590(gene)|ensembl:ENSG00000228425(gene)|ensembl:ENSG00000236014(gene)|ensembl:ENST00000383210(transcript)|ensembl:ENST00000428608(transcript)|ensembl:ENST00000441058(transcript)|ensembl:ENST00000443860(transcript)|ensembl:ENST00000445902(transcript)|ensembl:ENST00000448042(transcript)|go:"GO:0000938"(GARP complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010668"(ectodermal cell differentiation)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048611"(embryonic ectodermal digestive tract development)|go:"GO:0055037"(recycling endosome)|go:"GO:1990745"(EARP complex)|interpro:IPR007258(Vps52/Sac2)|reactome:R-HSA-6811440|ensembl:ENSG00000206286(gene)|refseq:NP_001276104.1|refseq:NP_072047.4|refseq:NP_001276105.1|refseq:XP_016866667.1|dip:DIP-57843N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:fMptnw5eMhxv+AzDK/+mSKrL7uY9606	rigid:k60tT93GoyEhOq3QywOxPSiiEYs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P20226	intact:EBI-15990239	intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054023|psi-mi:"MI:0471"|imex:IM-25807-727	author score:18.22	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606	rigid:TN/J0z5gU/eJTc9DhhbT/sgRFnI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P53365	intact:EBI-15990239	intact:EBI-638194|uniprotkb:D3DQT5|ensembl:ENSP00000254584|ensembl:ENSP00000379998|uniprotkb:B4E306|uniprotkb:B4DX86	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:arfp2_human(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Partner of RAC1(gene name synonym)|uniprotkb:ARFIP2(gene name)|psi-mi:ARFIP2(display_short)|uniprotkb:POR1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054011|psi-mi:"MI:0471"|imex:IM-25807-726	author score:16.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001229784.1|refseq:NP_036534.1|ensembl:ENSG00000132254(gene)|ensembl:ENST00000254584(transcript)|ensembl:ENST00000396777(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005525"(GTP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031529"(ruffle organization)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|rcsb pdb:1I49|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:4DCN|reactome:R-HSA-6811440|refseq:NP_001229785.1|refseq:XP_005252897.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:q3QMUWlBIW82Szrv9jbMR6ikOZg9606	rigid:3wi2up/Z9kHIm530YG9KX3e94VU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9Y2S7	intact:EBI-15990239	intact:EBI-713000|ensembl:ENSP00000475924|uniprotkb:Q96JE4|uniprotkb:B2R846	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdip2_human(display_long)|uniprotkb:38 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:POLDIP2(gene name)|psi-mi:POLDIP2(display_short)|uniprotkb:PDIP38(gene name synonym)|uniprotkb:POLD4(gene name synonym)|uniprotkb:HSPC017(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053999|psi-mi:"MI:0471"|imex:IM-25807-725	author score:16.18	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000004142(gene)|ensembl:ENST00000540200(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0070987"(error-free translesion synthesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903490"(positive regulation of mitotic cytokinesis)|go:"GO:1904531"(positive regulation of actin filament binding)|go:"GO:1990874"(vascular associated smooth muscle cell proliferation)|go:"GO:2001108"(positive regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR007474(ApaG)|interpro:IPR011722(Hemimethylated DNA-binding region)|interpro:IPR036623|interpro:IPR036767|mint:Q9Y2S7|rcsb pdb:6Z9C|refseq:NP_056399.1|refseq:NP_001277074.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:eZmek2xqphKowjP6zwsH6ydfz3g9606	rigid:6NKD2RO4V+6tjDFgxQV2wEe3NpY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O00308	intact:EBI-15990239	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053987|psi-mi:"MI:0471"|imex:IM-25807-724	author score:16.12	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:HuonOox2i+y4cN9DSSeoQe8TNA0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P04792	intact:EBI-15990239	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053975|psi-mi:"MI:0471"|imex:IM-25807-723	author score:15.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	-	-	crc64:1B4DC44A6F6606D5	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	rigid:lgOAJW6cm6dTY6TkdWjUdRPy/90	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O60885	intact:EBI-15990239	intact:EBI-723869|uniprotkb:O60433|uniprotkb:Q86YS8|uniprotkb:Q96PD3|intact:EBI-28968271|ensembl:ENSP00000263377|ensembl:ENSP00000506350|uniprotkb:Q4G0X8	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:brd4_human(display_long)|uniprotkb:Protein HUNK1(gene name synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053963|psi-mi:"MI:0471"|imex:IM-25807-722	author score:14.25	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_055114.1|refseq:NP_490597.1|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019899"(enzyme binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:0099122"(RNA polymerase II C-terminal domain binding)|go:"GO:0106140"(P-TEFb complex binding)|go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2001255"(positive regulation of histone H3-K36 trimethylation)|interpro:IPR001487(Bromodomain)|interpro:IPR018359|interpro:IPR027353|interpro:IPR031354|interpro:IPR036427|interpro:IPR038336|interpro:IPR043508|interpro:IPR043509|mint:O60885|rcsb pdb:2I8N|rcsb pdb:2LSP|rcsb pdb:2MJV|rcsb pdb:2N3K|rcsb pdb:2NCZ|rcsb pdb:2ND0|rcsb pdb:2ND1|rcsb pdb:2NNU|rcsb pdb:2OSS|rcsb pdb:2OUO|rcsb pdb:2YEL|rcsb pdb:2YEM|rcsb pdb:3MXF|rcsb pdb:5Y93|rcsb pdb:5Y94|rcsb pdb:5YOU|rcsb pdb:5YOV|rcsb pdb:5YQX|rcsb pdb:5Z1R|rcsb pdb:5Z1S|rcsb pdb:5Z1T|rcsb pdb:5Z5T|rcsb pdb:5Z5U|rcsb pdb:5Z5V|rcsb pdb:5Z8G|rcsb pdb:5Z8R|rcsb pdb:5Z8Z|rcsb pdb:5Z90|rcsb pdb:5Z9C|rcsb pdb:5Z9K|rcsb pdb:6AFR|rcsb pdb:6AJV|rcsb pdb:6AJW|rcsb pdb:6AJX|rcsb pdb:6AJY|rcsb pdb:6AJZ|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BNH|rcsb pdb:6BOY|rcsb pdb:6C7Q|rcsb pdb:6C7R|rcsb pdb:6CD4|rcsb pdb:6CD5|rcsb pdb:6CIS|rcsb pdb:6CIY|rcsb pdb:6CJ1|rcsb pdb:6CJ2|rcsb pdb:6CKR|rcsb pdb:6CKS|rcsb pdb:6CZU|rcsb pdb:6CZV|rcsb pdb:6DJC|rcsb pdb:6DL2|rcsb pdb:6DMJ|rcsb pdb:6DML|rcsb pdb:6DNE|rcsb pdb:6DUV|rcsb pdb:6FFD|rcsb pdb:6FNX|rcsb pdb:6FO5|rcsb pdb:6E4A|rcsb pdb:6FSY|rcsb pdb:6FT3|rcsb pdb:6FT4|rcsb pdb:6G0D|rcsb pdb:6G0E|rcsb pdb:6G0F|rcsb pdb:6G0G|rcsb pdb:6G0H|rcsb pdb:6G0O|rcsb pdb:6G0P|rcsb pdb:6G0Q|rcsb pdb:6G0R|rcsb pdb:6G0S|rcsb pdb:6HDQ|rcsb pdb:6HOV|rcsb pdb:6I7X|rcsb pdb:6I7Y|rcsb pdb:6IN1|rcsb pdb:6JI3|rcsb pdb:6JI4|rcsb pdb:6JI5|rcsb pdb:6JJ3|rcsb pdb:6JJ5|rcsb pdb:6JJ6|rcsb pdb:6JJB|rcsb pdb:6KEC|rcsb pdb:6KED|rcsb pdb:6KEE|rcsb pdb:6KEF|rcsb pdb:6KEG|rcsb pdb:6KEH|rcsb pdb:6KEI|rcsb pdb:6KEJ|rcsb pdb:6KEK|rcsb pdb:6KO2|rcsb pdb:6SB8|rcsb pdb:6SE4|rcsb pdb:6SIS|rcsb pdb:6LG4|rcsb pdb:6SWN|rcsb pdb:6SWQ|rcsb pdb:6TPX|rcsb pdb:6TPY|rcsb pdb:6TPZ|rcsb pdb:6U0D|rcsb pdb:6U6K|rcsb pdb:6U6L|rcsb pdb:6U72|rcsb pdb:6U74|rcsb pdb:6U8G|rcsb pdb:6U8I|rcsb pdb:6U8M|rcsb pdb:6ULS|rcsb pdb:6ULV|rcsb pdb:6UVJ|rcsb pdb:6UVM|rcsb pdb:6UWU|rcsb pdb:6UWX|rcsb pdb:6V0U|rcsb pdb:6V1K|rcsb pdb:6V1L|rcsb pdb:6V1U|rcsb pdb:3SVF|rcsb pdb:3SVG|rcsb pdb:3U5J|rcsb pdb:3U5K|rcsb pdb:3U5L|rcsb pdb:3UVW|rcsb pdb:3UVX|rcsb pdb:3UVY|rcsb pdb:3UW9|rcsb pdb:3ZYU|rcsb pdb:4A9L|rcsb pdb:4BJX|rcsb pdb:4BW1|rcsb pdb:4BW2|rcsb pdb:4BW3|rcsb pdb:4BW4|rcsb pdb:4C66|rcsb pdb:4C67|rcsb pdb:3P5O|rcsb pdb:4CFK|rcsb pdb:4CFL|rcsb pdb:4CL9|rcsb pdb:6LG6|rcsb pdb:6LG7|rcsb pdb:6LG8|rcsb pdb:6LG9|rcsb pdb:6LIH|rcsb pdb:6LIM|rcsb pdb:6MAU|rcsb pdb:6MH1|rcsb pdb:6MH7|rcsb pdb:6MNL|rcsb pdb:6P05|rcsb pdb:6PRT|rcsb pdb:6PS9|rcsb pdb:6PSB|rcsb pdb:6Q3Y|rcsb pdb:6LG5|rcsb pdb:6Q3Z|rcsb pdb:6RWJ|rcsb pdb:6S25|rcsb pdb:6S4B|rcsb pdb:6S6K|rcsb pdb:6SA2|rcsb pdb:6SA3|rcsb pdb:6SAH|rcsb pdb:6SAJ|rcsb pdb:4DON|rcsb pdb:4E96|rcsb pdb:4F3I|rcsb pdb:4GPJ|rcsb pdb:4HBV|rcsb pdb:4HBW|rcsb pdb:4HBX|rcsb pdb:4HBY|rcsb pdb:4HXK|rcsb pdb:4HXL|rcsb pdb:4HXM|rcsb pdb:4HXN|rcsb pdb:4HXO|rcsb pdb:4HXP|rcsb pdb:4HXR|rcsb pdb:4HXS|rcsb pdb:4IOO|rcsb pdb:4IOQ|rcsb pdb:4IOR|rcsb pdb:4J0R|rcsb pdb:4J0S|rcsb pdb:4J3I|rcsb pdb:4CLB|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:4LR6|rcsb pdb:4LRG|rcsb pdb:4LYI|rcsb pdb:4LYS|rcsb pdb:4LYW|rcsb pdb:4LZR|rcsb pdb:4LZS|rcsb pdb:4MEN|rcsb pdb:4MEO|rcsb pdb:4MEP|rcsb pdb:4MEQ|rcsb pdb:4MR3|rcsb pdb:4MR4|rcsb pdb:4NQM|rcsb pdb:4NR8|rcsb pdb:4NUC|rcsb pdb:4NUD|rcsb pdb:4NUE|rcsb pdb:4O70|rcsb pdb:4O71|rcsb pdb:4O72|rcsb pdb:4O74|rcsb pdb:4O75|rcsb pdb:4O76|rcsb pdb:4O77|rcsb pdb:4O78|rcsb pdb:4O7A|rcsb pdb:4O7B|rcsb pdb:4O7C|rcsb pdb:4O7E|rcsb pdb:4O7F|rcsb pdb:4OGI|rcsb pdb:4OGJ|rcsb pdb:4PCE|rcsb pdb:4PCI|rcsb pdb:4PS5|rcsb pdb:4QR3|rcsb pdb:4QR4|rcsb pdb:4QR5|rcsb pdb:4QZS|rcsb pdb:4UIX|rcsb pdb:4UIY|rcsb pdb:4UIZ|rcsb pdb:4UYD|rcsb pdb:4WHW|rcsb pdb:4WIV|rcsb pdb:4X2I|rcsb pdb:4XY9|rcsb pdb:4XYA|rcsb pdb:4YH3|rcsb pdb:4YH4|rcsb pdb:4Z1Q|rcsb pdb:4QB3|rcsb pdb:4Z1S|rcsb pdb:4Z93|rcsb pdb:4ZC9|rcsb pdb:4ZW1|rcsb pdb:5ACY|rcsb pdb:5AD2|rcsb pdb:5AD3|rcsb pdb:5BT4|rcsb pdb:5CFW|rcsb pdb:5COI|rcsb pdb:5CP5|rcsb pdb:5CPE|rcsb pdb:5CQT|rcsb pdb:5A5S|rcsb pdb:5CRM|rcsb pdb:5CRZ|rcsb pdb:5CS8|rcsb pdb:5CTL|rcsb pdb:5CY9|rcsb pdb:5D0C|rcsb pdb:5D24|rcsb pdb:5D25|rcsb pdb:5D26|rcsb pdb:5D3H|rcsb pdb:5D3J|rcsb pdb:5D3L|rcsb pdb:5D3N|rcsb pdb:5D3P|rcsb pdb:5A85|rcsb pdb:5D3R|rcsb pdb:5D3S|rcsb pdb:5D3T|rcsb pdb:5DLX|rcsb pdb:5DLZ|rcsb pdb:5DX4|rcsb pdb:5E0R|rcsb pdb:5EGU|rcsb pdb:5EI4|rcsb pdb:5EIS|rcsb pdb:5F5Z|rcsb pdb:5F60|rcsb pdb:5F61|rcsb pdb:5F62|rcsb pdb:5F63|rcsb pdb:5FBX|rcsb pdb:5H21|rcsb pdb:5HCL|rcsb pdb:5HLS|rcsb pdb:5HM0|rcsb pdb:5HQ5|rcsb pdb:5HQ6|rcsb pdb:5HQ7|rcsb pdb:5I80|rcsb pdb:5I88|rcsb pdb:5IGK|rcsb pdb:5JWM|rcsb pdb:5KDH|rcsb pdb:5KHM|rcsb pdb:5KJ0|rcsb pdb:5KU3|rcsb pdb:5LJ1|rcsb pdb:5LJ2|rcsb pdb:5LRQ|rcsb pdb:5LUU|rcsb pdb:5M39|rcsb pdb:5M3A|rcsb pdb:5MKZ|rcsb pdb:5DW2|rcsb pdb:5MLI|rcsb pdb:5N2M|rcsb pdb:5NNC|rcsb pdb:5NND|rcsb pdb:5NNE|rcsb pdb:5NNF|rcsb pdb:5NNG|rcsb pdb:5O97|rcsb pdb:5UES|rcsb pdb:5UET|rcsb pdb:5OVB|rcsb pdb:5OWM|rcsb pdb:5UEU|rcsb pdb:5UEV|rcsb pdb:5UEX|rcsb pdb:5UEY|rcsb pdb:5UEZ|rcsb pdb:5OWW|rcsb pdb:5UF0|rcsb pdb:5ULA|rcsb pdb:5UOO|rcsb pdb:5UVS|rcsb pdb:5UVT|rcsb pdb:5UVU|rcsb pdb:5UVV|rcsb pdb:5UVW|rcsb pdb:5T35|rcsb pdb:5TI2|rcsb pdb:5TI3|rcsb pdb:5TI4|rcsb pdb:5TI5|rcsb pdb:5TI6|rcsb pdb:5TI7|rcsb pdb:5U28|rcsb pdb:5U2C|rcsb pdb:5U2E|rcsb pdb:5U2F|rcsb pdb:5UVX|rcsb pdb:5UVY|rcsb pdb:5UVZ|rcsb pdb:5V67|rcsb pdb:5VBO|rcsb pdb:5VBP|rcsb pdb:5UEO|rcsb pdb:5VOM|rcsb pdb:5VZS|rcsb pdb:5W55|rcsb pdb:5WA5|rcsb pdb:5WMA|rcsb pdb:5WMD|rcsb pdb:5WMG|rcsb pdb:5WUU|rcsb pdb:5UEP|rcsb pdb:5XHY|rcsb pdb:5UEQ|rcsb pdb:5XI2|rcsb pdb:5XI3|rcsb pdb:5UER|rcsb pdb:5XI4|rcsb pdb:5Y1Y|rcsb pdb:5Y8C|rcsb pdb:5Y8W|rcsb pdb:5Y8Y|rcsb pdb:5Y8Z|rcsb pdb:6VIW|rcsb pdb:6VIX|rcsb pdb:6VIZ|ensembl:ENSP00000263377|ensembl:ENST00000360016|ensembl:ENSP00000353112|ensembl:ENST00000371835|ensembl:ENSP00000360901|ensembl:ENSP00000506350|rcsb pdb:7A9U|rcsb pdb:7AJN|rcsb pdb:7C2Z|rcsb pdb:7C6P|rcsb pdb:7JKX|rcsb pdb:7KHH|rcsb pdb:7KHL|rcsb pdb:7MCF|reactome:R-HSA-9679191|rcsb pdb:6ZF9|rcsb pdb:6VUC|rcsb pdb:6VUF|rcsb pdb:6VUJ|rcsb pdb:6WGX|rcsb pdb:6WW8|rcsb pdb:6X7B|rcsb pdb:6X7C|rcsb pdb:6X7D|rcsb pdb:6XUZ|rcsb pdb:6XV3|rcsb pdb:6XV7|rcsb pdb:6XVC|rcsb pdb:6YIN|rcsb pdb:6YQN|rcsb pdb:6YQO|rcsb pdb:6YQP|rcsb pdb:6YQZ|rcsb pdb:6Z7G|rcsb pdb:6Z7L|rcsb pdb:6Z7M|rcsb pdb:6ZB3|rcsb pdb:6ZCI|rcsb pdb:6ZED|rcsb pdb:6ZEL|rcsb pdb:6VUB|refseq:NP_001317313.1|refseq:XP_011526156.1|refseq:XP_011526158.1|dip:DIP-39776N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:KW4ZOJouhppNcycIJh1J1JkwBd8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q07955	intact:EBI-15990239	intact:EBI-398920|uniprotkb:Q13809|uniprotkb:B2R6Z7|uniprotkb:D3DTZ3|ensembl:ENSP00000258962	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf1_human(display_long)|uniprotkb:SF2(gene name synonym)|uniprotkb:SF2P33(gene name synonym)|uniprotkb:OK/SW-cl.3(orf name)|uniprotkb:SRSF1(gene name)|psi-mi:SRSF1(display_short)|uniprotkb:ASF(gene name synonym)|uniprotkb:pre-mRNA-splicing factor SF2, P33 subunit(gene name synonym)|uniprotkb:Alternative-splicing factor 1(gene name synonym)|uniprotkb:SFRS1(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053951|psi-mi:"MI:0471"|imex:IM-25807-721	author score:13.21	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001071634.1|refseq:NP_008855.1|dip:DIP-2155N|ensembl:ENSG00000136450(gene)|ensembl:ENST00000258962(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000395"(mRNA 5'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097421"(liver regeneration)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034520|interpro:IPR035979|mint:Q07955|rcsb pdb:2M7S|rcsb pdb:2M8D|rcsb pdb:2O3D|rcsb pdb:3BEG|rcsb pdb:4C0O|rcsb pdb:6HPJ|rcsb pdb:7ABG|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856|rcsb pdb:1X4A	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:6/IA4a3btkfSBtMH32iCe+rqZ8Y9606	rigid:/jieEl5Q1t63GdWKtidv297R8fA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q14533	intact:EBI-15990239	intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053939|psi-mi:"MI:0471"|imex:IM-25807-720	author score:13.19	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606	rigid:2thEQqkbg5rkBBPfDSSSz+EIBqQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q66K74	intact:EBI-15990239	intact:EBI-2133734|uniprotkb:Q8N3W5|uniprotkb:Q8NI88|uniprotkb:Q8N3L8|uniprotkb:Q27QB1|uniprotkb:Q96H94|uniprotkb:Q96IT4|uniprotkb:Q96SP8|uniprotkb:Q9BRC6|uniprotkb:Q9H928|uniprotkb:Q9NVK7|uniprotkb:Q6NXF1|ensembl:ENSP00000325313|intact:EBI-2556419|intact:EBI-10978604|uniprotkb:B4DH53|intact:EBI-28978421	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:map1s_human(display_long)|uniprotkb:MAP1S(gene name)|psi-mi:MAP1S(display_short)|uniprotkb:BPY2IP1(gene name synonym)|uniprotkb:C19orf5(gene name synonym)|uniprotkb:MAP8(gene name synonym)|uniprotkb:VCY2IP1(gene name synonym)|uniprotkb:BPY2-interacting protein 1(gene name synonym)|uniprotkb:Microtubule-associated protein 8(gene name synonym)|uniprotkb:Variable charge Y chromosome 2-interacting protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053927|psi-mi:"MI:0471"|imex:IM-25807-719	author score:11.58	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSG00000130479(gene)|ensembl:ENST00000324096(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007409"(axonogenesis)|refseq:NP_001295292.1|go:"GO:0007420"(brain development)|go:"GO:0008017"(microtubule binding)|go:"GO:0010848"(regulation of chromatin disassembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016358"(dendrite development)|go:"GO:0030054"(cell junction)|go:"GO:0030425"(dendrite)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051015"(actin filament binding)|interpro:IPR026074|ensembl:ENSP00000325313|ensembl:ENST00000544059|ensembl:ENSP00000439243|refseq:NP_060644.4|interpro:IPR027322|mint:Q66K74	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:f+UnRFHFEFKp2fTRCHt4/HXtnFQ9606	rigid:Q9/zjCwH38Xetu0tmymQGfyQVjU	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96JC1	intact:EBI-15990239	intact:EBI-1050197|uniprotkb:O94869|uniprotkb:Q7Z3V3|uniprotkb:Q96B93|uniprotkb:Q96RM0|uniprotkb:Q71SQ6|ensembl:ENSP00000335193	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:vps39_human(display_long)|uniprotkb:KIAA0770(gene name synonym)|uniprotkb:VPS39(gene name)|psi-mi:VPS39(display_short)|uniprotkb:VAM6(gene name synonym)|uniprotkb:TLP(gene name synonym)|uniprotkb:TRAP1-like protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053915|psi-mi:"MI:0471"|imex:IM-25807-718	author score:10.33	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056104.2|refseq:NP_001288067.1|ensembl:ENSG00000166887(gene)|ensembl:ENST00000348544(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016020"(membrane)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030897"(HOPS complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1902501"(lysosomal HOPS complex)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR001180(Citron-like)|interpro:IPR019452|interpro:IPR019453|interpro:IPR032914|rcsb pdb:6ZE9	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:BeY8ZDCOyTvZqA0WpdWnmz+giYk9606	rigid:7IMKkh6Yuiu/CG9xFBZuBBWooSk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q15223	intact:EBI-15990239	intact:EBI-1771314|uniprotkb:O75465|uniprotkb:Q2M3D3|uniprotkb:Q9HBE6|uniprotkb:Q9HBW2|ensembl:ENSP00000264025	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nect1_human(display_long)|uniprotkb:NECTIN1(gene name)|psi-mi:NECTIN1(display_short)|uniprotkb:HVEC(gene name synonym)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Herpesvirus Ig-like receptor(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:PRR1(gene name synonym)|uniprotkb:PVRL1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16053903|psi-mi:"MI:0471"|imex:IM-25807-717	author score:10.03	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002846.3|refseq:NP_976030.1|refseq:NP_976031.1|dip:DIP-40302N|ensembl:ENSG00000110400(gene)|ensembl:ENST00000264025(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:3ALP|rcsb pdb:3SKU|rcsb pdb:3U82|rcsb pdb:3U83|rcsb pdb:4FMF|rcsb pdb:4MYW|reactome:R-HSA-418990|reactome:R-HSA-420597	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:/KqZN5Vhyc6Qrih7IyHnkN8nsaE9606	rigid:nHvUXdfWWkLgENDhebcJmODagx0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P13667	intact:EBI-15990239	intact:EBI-1054653|uniprotkb:A8K4K6|uniprotkb:Q549T6|ensembl:ENSP00000499129	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pdia4_human(display_long)|uniprotkb:Endoplasmic reticulum resident protein 72(gene name synonym)|uniprotkb:PDIA4(gene name)|psi-mi:PDIA4(display_short)|uniprotkb:ERP70(gene name synonym)|uniprotkb:ERP72(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 70(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054599|psi-mi:"MI:0471"|imex:IM-25807-775	author score:9.69	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004902.1|ensembl:ENSG00000155660(gene)|ensembl:ENST00000652332(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017068(Protein disulphide-isomerase A4)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041866|mint:P13667|rcsb pdb:3IDV	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:m9nI8RSOEnIsBjDnQa4fbkT+v2Y9606	rigid:5u27+lNK8CehwTHXD127QnHx2no	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P26641	intact:EBI-15990239	intact:EBI-351467|uniprotkb:Q6PJ62|uniprotkb:Q6PK31|uniprotkb:Q96CU2|uniprotkb:Q9P196|intact:EBI-2321928|uniprotkb:B4DTG2|ensembl:ENSP00000331901	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ef1g_human(display_long)|uniprotkb:PRO1608(orf name)|uniprotkb:EEF1G(gene name)|psi-mi:EEF1G(display_short)|uniprotkb:EF1G(gene name synonym)|uniprotkb:eEF-1B gamma(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054587|psi-mi:"MI:0471"|imex:IM-25807-774	author score:9.66	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001395.1|ensembl:ENSG00000254772(gene)|ensembl:ENST00000329251(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006414"(translational elongation)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001662(Translation elongation factor EF1B, gamma chain, conserved)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282|interpro:IPR036433|interpro:IPR040079|mint:P26641|rcsb pdb:1PBU|rcsb pdb:5DQS|rcsb pdb:5JPO|reactome:R-HSA-156842|dip:DIP-32516N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:biVN96umeEdPm/wvPN4VwbSRHTs9606	rigid:L6iI2poikQmlrHi9VGlhY+HpYW0	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96BJ3	intact:EBI-15990239	intact:EBI-4401674|uniprotkb:A8K1F0|uniprotkb:Q49A81|uniprotkb:Q5JRA4|uniprotkb:Q658P1|uniprotkb:Q9H9E8|ensembl:ENSP00000339161	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:aida_human(display_long)|uniprotkb:AIDA(gene name)|psi-mi:AIDA(display_short)|uniprotkb:C1orf80(gene name synonym)|uniprotkb:Axin interaction partner and dorsalization antagonist(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054575|psi-mi:"MI:0471"|imex:IM-25807-773	author score:9.35	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_073742.2|ensembl:ENSG00000186063(gene)|ensembl:ENST00000340020(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0016020"(membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048264"(determination of ventral identity)|interpro:IPR023421|interpro:IPR025939|interpro:IPR035892|interpro:IPR036818	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:Eo7oyV29ug5MrDH2coUbbW68pdc9606	rigid:0OPErmC4de+yvm86vhQDzPgD850	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q07817	intact:EBI-15990239	intact:EBI-78035|intact:EBI-28978054|ensembl:ENSP00000302564|ensembl:ENSP00000365230|ensembl:ENSP00000389688|ensembl:ENSP00000390760|ensembl:ENSP00000395545|ensembl:ENSP00000401173|ensembl:ENSP00000503725|ensembl:ENSP00000504237|ensembl:ENSP00000504387|ensembl:ENSP00000504536|uniprotkb:Q5TE65|uniprotkb:Q92976|uniprotkb:Q5CZ89|uniprotkb:E1P5L6	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2cl1_human(display_long)|uniprotkb:BCL2L1(gene name)|psi-mi:BCL2L1(display_short)|uniprotkb:BCL2L(gene name synonym)|uniprotkb:BCLX(gene name synonym)|uniprotkb:Apoptosis regulator Bcl-X(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054563|psi-mi:"MI:0471"|imex:IM-25807-772	author score:9.30	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001182.1|refseq:NP_612815.1|ensembl:ENSG00000171552(gene)|ensembl:ENST00000307677(transcript)|ensembl:ENST00000376062(transcript)|ensembl:ENST00000420488(transcript)|ensembl:ENST00000434194(transcript)|ensembl:ENST00000439267(transcript)|ensembl:ENST00000456404(transcript)|ensembl:ENST00000676582(transcript)|ensembl:ENST00000676942(transcript)|ensembl:ENST00000677194(transcript)|ensembl:ENST00000678563(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0007281"(germ cell development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009566"(fertilization)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019050"(suppression by virus of host apoptotic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034097"(response to cytokine)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046898"(response to cycloheximide)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071839"(apoptotic process in bone marrow cell)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1900118"(negative regulation of execution phase of apoptosis)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR004725(Apoptosis regulator Bcl-X protein)|interpro:IPR013279(Apoptosis regulator, Bcl-X)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR020731|interpro:IPR026298|interpro:IPR036834|mint:Q07817|rcsb pdb:1BXL|rcsb pdb:1G5J|rcsb pdb:1LXL|rcsb pdb:1MAZ|rcsb pdb:1R2D|rcsb pdb:1R2E|rcsb pdb:1R2G|rcsb pdb:1R2H|rcsb pdb:1R2I|rcsb pdb:1YSG|rcsb pdb:1YSI|rcsb pdb:1YSN|rcsb pdb:2B48|rcsb pdb:2LP8|rcsb pdb:2LPC|rcsb pdb:2M03|rcsb pdb:2M04|rcsb pdb:2ME8|rcsb pdb:2ME9|rcsb pdb:2MEJ|rcsb pdb:2O1Y|rcsb pdb:2O2M|rcsb pdb:2O2N|rcsb pdb:2P1L|rcsb pdb:2PON|rcsb pdb:2YJ1|rcsb pdb:2YQ6|rcsb pdb:2YQ7|rcsb pdb:2YXJ|rcsb pdb:3CVA|rcsb pdb:3FDL|rcsb pdb:3FDM|rcsb pdb:3INQ|rcsb pdb:3IO8|rcsb pdb:3PL7|rcsb pdb:3QKD|rcsb pdb:3R85|rcsb pdb:6IJQ|rcsb pdb:6LHD|rcsb pdb:6O0K|rcsb pdb:6O0L|rcsb pdb:6O0M|rcsb pdb:6O0O|rcsb pdb:6O0P|rcsb pdb:6RNU|rcsb pdb:6ST2|rcsb pdb:6UVC|rcsb pdb:6UVD|rcsb pdb:6UVE|rcsb pdb:6UVF|rcsb pdb:6UVG|rcsb pdb:6UVH|rcsb pdb:6VWC|rcsb pdb:6X7I|rcsb pdb:6YLI|rcsb pdb:6ZHC|rcsb pdb:7CA4|rcsb pdb:7JGV|rcsb pdb:7JGW|rcsb pdb:7LH7|reactome:R-HSA-111453|reactome:R-HSA-6785807|reactome:R-HSA-844455|reactome:R-HSA-9648002|reactome:R-HSA-9702518|rcsb pdb:3SP7|rcsb pdb:3SPF|rcsb pdb:3WIZ|rcsb pdb:3ZK6|rcsb pdb:3ZLN|rcsb pdb:6F46|rcsb pdb:6HJL|rcsb pdb:3ZLO|rcsb pdb:3ZLR|rcsb pdb:4A1U|rcsb pdb:4A1W|rcsb pdb:4AQ3|rcsb pdb:4BPK|rcsb pdb:4C52|rcsb pdb:4C5D|rcsb pdb:4CIN|rcsb pdb:4EHR|rcsb pdb:4HNJ|rcsb pdb:4IEH|rcsb pdb:4PPI|rcsb pdb:4QVE|rcsb pdb:4QVF|rcsb pdb:4QVX|rcsb pdb:4TUH|rcsb pdb:4Z9V|rcsb pdb:5AGW|rcsb pdb:5AGX|rcsb pdb:5B1Z|rcsb pdb:5C3G|rcsb pdb:5FMJ|rcsb pdb:5FMK|rcsb pdb:5VAY|rcsb pdb:5VX3|rcsb pdb:6BF2|rcsb pdb:6DCN|rcsb pdb:6DCO|ensembl:ENSP00000365223|ensembl:ENSP00000365230|ensembl:ENSP00000390760|ensembl:ENST00000376055|ensembl:ENST00000422920|ensembl:ENSP00000411252|ensembl:ENSP00000401173|ensembl:ENSP00000389688|ensembl:ENSP00000395545|ensembl:ENSP00000503725|ensembl:ENSP00000504536|ensembl:ENSP00000504387|ensembl:ENSP00000504237|ensembl:ENSP00000302564|refseq:NP_001304848.1|refseq:NP_001304849.1|refseq:NP_001304850.1|refseq:NP_001309168.1|refseq:NP_001309169.1|refseq:NP_001309171.1|refseq:XP_011527266.1|refseq:XP_016883482.1|dip:DIP-30916N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:lDDsMUf2W6uLKpfM3h4N364tpWg9606	rigid:PZi57B2Eeynpg07Os6Qa4qFaF9g	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q14289	intact:EBI-15990239	intact:EBI-298640|uniprotkb:Q13475|uniprotkb:Q14290|uniprotkb:Q16709|intact:EBI-2211226|uniprotkb:Q6PID4|ensembl:ENSP00000332816|ensembl:ENSP00000380638|uniprotkb:D3DST0	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:fak2_human(display_long)|uniprotkb:PTK2B(gene name)|psi-mi:PTK2B(display_short)|uniprotkb:FAK2(gene name synonym)|uniprotkb:PYK2(gene name synonym)|uniprotkb:RAFTK(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054551|psi-mi:"MI:0471"|imex:IM-25807-771	author score:9.26	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_004094.3|refseq:NP_775266.1|refseq:NP_775267.1|refseq:NP_775268.1|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|rcsb pdb:2FO6|rcsb pdb:2LK4|rcsb pdb:3CC6|rcsb pdb:3ET7|rcsb pdb:3FZO|rcsb pdb:3FZP|rcsb pdb:3FZR|rcsb pdb:3FZS|rcsb pdb:3FZT|rcsb pdb:3GM1|rcsb pdb:3GM2|rcsb pdb:3GM3|rcsb pdb:3H3C|rcsb pdb:3U3F|rcsb pdb:4EKU|rcsb pdb:4H1J|rcsb pdb:4H1M|rcsb pdb:4R32|rcsb pdb:4XEF|rcsb pdb:4XEK|rcsb pdb:4XEV|rcsb pdb:5TO8|rcsb pdb:5TOB|rcsb pdb:6LF3|reactome:R-HSA-391160|reactome:R-HSA-4420097|reactome:R-HSA-9020558|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0045453"(bone resorption)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|ensembl:ENSG00000120899(gene)|ensembl:ENST00000346049(transcript)|ensembl:ENST00000397501(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|refseq:XP_011542743.1|refseq:XP_005273504.1|refseq:XP_016868703.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:rpqjaDBbtx7BK+JiIR/sBlyPLvY9606	rigid:+s9JPC48zEvKmZOFEc7CGj/Uy/k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q96T23	intact:EBI-15990239	intact:EBI-926768|uniprotkb:Q86X86|uniprotkb:Q9H3L8|uniprotkb:Q9NVZ8|uniprotkb:Q9NYU0|intact:EBI-28986425|ensembl:ENSP00000311513	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:rsf1_human(display_long)|uniprotkb:RSF1(gene name)|psi-mi:RSF1(display_short)|uniprotkb:HBXAP(gene name synonym)|uniprotkb:XAP8(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein(gene name synonym)|uniprotkb:HBV pX-associated protein 8(gene name synonym)|uniprotkb:p325 subunit of RSF chromatin-remodeling complex(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054539|psi-mi:"MI:0471"|imex:IM-25807-770	author score:89.78	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057662.3|ensembl:ENSP00000311513|ensembl:ENST00000480887|ensembl:ENSP00000434509|ensembl:ENSG00000048649(gene)|ensembl:ENST00000308488(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0031213"(RSF complex)|go:"GO:0042393"(histone binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050434"(positive regulation of viral transcription)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR028938|interpro:IPR028942|reactome:R-HSA-606279	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:IoJZ6mEd2NHhbjnGJnPtWw+3dcE9606	rigid:Hl5KeVFBJNvJAKTJfTCGEblKagM	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9H5V8	intact:EBI-15990239	intact:EBI-1019736|uniprotkb:Q49UB4|uniprotkb:Q6NT71|uniprotkb:Q6U9Y2|uniprotkb:Q8WU91|uniprotkb:Q96QU7|uniprotkb:Q9H676|uniprotkb:Q9H8C2|ensembl:ENSP00000296129	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cdcp1_human(display_long)|uniprotkb:CDCP1(gene name)|psi-mi:CDCP1(display_short)|uniprotkb:TRASK(gene name synonym)|uniprotkb:UNQ2486/PRO5773(orf name)|uniprotkb:Transmembrane and associated with src kinases(gene name synonym)|uniprotkb:Membrane glycoprotein gp140(gene name synonym)|uniprotkb:Subtractive immunization M plus HEp3-associated 135 kDa protein(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054527|psi-mi:"MI:0471"|imex:IM-25807-769	author score:8.75	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_073753.3|refseq:NP_835488.1|dip:DIP-33861N|ensembl:ENSG00000163814(gene)|ensembl:ENST00000296129(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR035914|interpro:IPR038811	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:sAXK+WNzP2qtJ53Fu6+cuehNA289606	rigid:9WeKsN+lP9oARQoY7JsIoJ9AM3I	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O15305	intact:EBI-15990239	intact:EBI-10182608|uniprotkb:D3DUF3|uniprotkb:B7Z6R0|uniprotkb:A8K672|ensembl:ENSP00000268261	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pmm2_human(display_long)|uniprotkb:PMM2(gene name)|psi-mi:PMM2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054515|psi-mi:"MI:0471"|imex:IM-25807-768	author score:8.34	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_000294.1|ensembl:ENSG00000140650(gene)|ensembl:ENST00000268261(transcript)|go:"GO:0004615"(phosphomannomutase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0009298"(GDP-mannose biosynthetic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|interpro:IPR005002(Eukaryotic phosphomannomutase)|interpro:IPR006379(HAD-superfamily hydrolase, subfamily IIB)|interpro:IPR023214|interpro:IPR036412|interpro:IPR043169|mint:O15305|rcsb pdb:2AMY|rcsb pdb:2Q4R|reactome:R-HSA-4043911|reactome:R-HSA-446205	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:3PhPMapZgZUgnd1/ddww/ciXQKU9606	rigid:X7bDbwkWDHv42LPfmwG67zdSPLs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9NRL2	intact:EBI-15990239	intact:EBI-927511|uniprotkb:Q9NZ15|uniprotkb:Q9P065|uniprotkb:Q9UIG1|uniprotkb:Q9Y3V3|ensembl:ENSP00000353458|ensembl:ENSP00000371859	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:baz1a_human(display_long)|uniprotkb:BAZ1A(gene name)|psi-mi:BAZ1A(display_short)|uniprotkb:ACF1(gene name synonym)|uniprotkb:WCRF180(gene name synonym)|uniprotkb:HSPC317(orf name)|uniprotkb:ATP-utilizing chromatin assembly and remodeling factor 1(gene name synonym)|uniprotkb:ATP-dependent chromatin-remodeling protein(gene name synonym)|uniprotkb:Williams syndrome transcription factor-related chromatin-remodeling factor 180(gene name synonym)|uniprotkb:CHRAC subunit ACF1(gene name synonym)|uniprotkb:hWALp1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054503|psi-mi:"MI:0471"|imex:IM-25807-767	author score:8.14	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_038476.2|refseq:NP_872589.1|dip:DIP-36071N|ensembl:ENSG00000198604(gene)|ensembl:ENST00000360310(transcript)|ensembl:ENST00000382422(transcript)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008623"(CHRAC)|go:"GO:0016573"(histone acetylation)|go:"GO:0016590"(ACF complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013136(WSTF/Acf1/Cbp146)|interpro:IPR018359|interpro:IPR018501|interpro:IPR019786|interpro:IPR019787|interpro:IPR028941|interpro:IPR028942|interpro:IPR036427|interpro:IPR037325|rcsb pdb:5UIY	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:1N6/uH2kUWs1/HdPhSI2a/UnbqI9606	rigid:4zmOAQayjSz4ixKpW4QUserydps	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P02751	intact:EBI-15990239	intact:EBI-1220319|uniprotkb:Q7Z391|uniprotkb:O95609|uniprotkb:O95610|uniprotkb:Q14312|uniprotkb:Q14325|uniprotkb:Q14326|uniprotkb:Q17RV7|uniprotkb:Q585T2|uniprotkb:Q59EH1|uniprotkb:Q60FE4|uniprotkb:Q68DP8|uniprotkb:Q68DP9|uniprotkb:Q68DT4|uniprotkb:Q6LDP6|uniprotkb:Q6MZU5|uniprotkb:Q6N025|uniprotkb:Q6N0A6|uniprotkb:Q86T27|uniprotkb:Q8IVI8|uniprotkb:Q96KP7|uniprotkb:Q96KP8|uniprotkb:Q96KP9|uniprotkb:Q9H1B8|uniprotkb:Q9HAP3|uniprotkb:Q9UMK2|uniprotkb:Q6MZS0|uniprotkb:B7ZLF0|uniprotkb:E9PE77|uniprotkb:E9PG29|uniprotkb:Q564H7|uniprotkb:Q53S27|ensembl:ENSP00000346839	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:finc_human(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short)|uniprotkb:FN(gene name synonym)|uniprotkb:Cold-insoluble globulin(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054491|psi-mi:"MI:0471"|imex:IM-25807-766	author score:7.95	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_002017.1|refseq:NP_473375.2|refseq:NP_997639.1|refseq:NP_997641.1|refseq:NP_997643.1|refseq:NP_997647.1|refseq:NP_001293058.1|refseq:NP_001293059.1|refseq:NP_001293060.1|refseq:NP_001293061.1|refseq:XP_005246463.1|dip:DIP-29547N|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009611"(response to wounding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|ensembl:ENSG00000115414(gene)|ensembl:ENST00000354785(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005577"(fibrinogen complex)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0072562"(blood microparticle)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P02751|rcsb pdb:1E88|rcsb pdb:1E8B|rcsb pdb:1FBR|rcsb pdb:1FNA|rcsb pdb:1FNF|rcsb pdb:1FNH|rcsb pdb:1J8K|rcsb pdb:1O9A|rcsb pdb:1OWW|rcsb pdb:1Q38|rcsb pdb:1QGB|rcsb pdb:1QO6|rcsb pdb:1TTF|rcsb pdb:1TTG|rcsb pdb:2CG6|rcsb pdb:2CG7|rcsb pdb:2CK2|rcsb pdb:2CKU|rcsb pdb:2EC3|rcsb pdb:2FN2|rcsb pdb:2FNB|rcsb pdb:2GEE|rcsb pdb:2H41|rcsb pdb:2H45|rcsb pdb:2HA1|rcsb pdb:2MNU|rcsb pdb:2N1K|rcsb pdb:2OCF|rcsb pdb:2RKY|rcsb pdb:2RKZ|rcsb pdb:2RL0|rcsb pdb:3CAL|rcsb pdb:3EJH|rcsb pdb:3GXE|rcsb pdb:3M7P|rcsb pdb:3MQL|rcsb pdb:3R8Q|rcsb pdb:3T1W|rcsb pdb:3ZRZ|rcsb pdb:4GH7|rcsb pdb:4JE4|rcsb pdb:4JEG|rcsb pdb:4LXO|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|rcsb pdb:4PZ5|rcsb pdb:5DC0|rcsb pdb:5DC4|rcsb pdb:5DC9|rcsb pdb:5DFT|rcsb pdb:5J6Z|rcsb pdb:5J7C|rcsb pdb:5M0A|rcsb pdb:5N47|rcsb pdb:5N48|rcsb pdb:6HNF|rcsb pdb:6MFA|rcsb pdb:6MSV|rcsb pdb:6NAJ|rcsb pdb:6XAX|rcsb pdb:6XAY|rcsb pdb:7NWL|reactome:R-HSA-114608|reactome:R-HSA-1474228|reactome:R-HSA-1474244|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381426|reactome:R-HSA-5674135|reactome:R-HSA-6785807|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8874081|reactome:R-HSA-8957275|reactome:R-HSA-9649948|reactome:R-HSA-9656223	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2019/10/18	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:4arZu49X8b+dthqaX4DIh59V8h09606	rigid:888zvwM1mSM8SP404+wmU1qtISs	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P02538	intact:EBI-15990239	intact:EBI-702198|uniprotkb:P48667|uniprotkb:Q08AR4|uniprotkb:Q6NT67|uniprotkb:Q96CL4|uniprotkb:A4QPC1|ensembl:ENSP00000369317	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:k2c6a_human(display_long)|uniprotkb:Cytokeratin-6A(gene name synonym)|uniprotkb:Keratin-6A(gene name synonym)|uniprotkb:Cytokeratin-6D(gene name synonym)|uniprotkb:KRT6A(gene name)|psi-mi:KRT6A(display_short)|uniprotkb:K6A(gene name synonym)|uniprotkb:KRT6D(gene name synonym)|uniprotkb:Type-II keratin Kb6(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054479|psi-mi:"MI:0471"|imex:IM-25807-765	author score:7.31	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_005545.1|dip:DIP-533N|ensembl:ENSG00000205420(gene)|ensembl:ENST00000330722(transcript)|go:"GO:0001899"(negative regulation of cytolysis by symbiont of host cells)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0045095"(keratin filament)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051838"(cytolysis by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P02538|rcsb pdb:5KI0|reactome:R-HSA-6805567|reactome:R-HSA-6809371	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:feIxUFTSMnjattUda5vdGhiL9H89606	rigid:mdyNmXCpy+0p7NXDCA9mQGdkYgw	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZP9	uniprotkb:P36778	intact:EBI-7962814|uniprotkb:Q9Y3A7|intact:MINT-3065126|ensembl:ENSP00000158771	intact:EBI-15990239	psi-mi:derl2_human(display_long)|uniprotkb:DERL2(gene name)|psi-mi:DERL2(display_short)|uniprotkb:DER2(gene name synonym)|uniprotkb:FLANA(gene name synonym)|uniprotkb:CGI-101(orf name)|uniprotkb:SBBI53(orf name)|uniprotkb:Der1-like protein 2(gene name synonym)|uniprotkb:Degradation in endoplasmic reticulum protein 2(gene name synonym)|uniprotkb:F-LAN-1(gene name synonym)|uniprotkb:F-LANa(gene name synonym)	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054467|psi-mi:"MI:0471"|imex:IM-25807-764	author score:7.24	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001291708.1|refseq:NP_057125.2|ensembl:ENSG00000072849(gene)|ensembl:ENST00000158771(transcript)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001967"(suckling behavior)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR007599(Der1-like)|interpro:IPR035952|reactome:R-HSA-382556|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-901032	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	-	comment:mint|function:"Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation"	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:hoayS/Xn9+pq/C61NYRu/1aOm6s9606	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rigid:+TdVm6iEzwM4E44qEoYHgQoVj2k	false	gaussia-n:?-?("MI:2221")	gaussia-c:?-?("MI:2220")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9BXK5	intact:EBI-15990239	intact:EBI-747430|uniprotkb:Q96B37|uniprotkb:Q96IB7|uniprotkb:Q9BY01|uniprotkb:Q9HC05|uniprotkb:Q9UFE0|uniprotkb:Q9UKN3|ensembl:ENSP00000318883|uniprotkb:B3KPE7	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:b2l13_human(display_long)|uniprotkb:Protein Mil1(gene name synonym)|uniprotkb:Bcl-rambo(gene name synonym)|uniprotkb:BCL2L13(gene name)|psi-mi:BCL2L13(display_short)|uniprotkb:MIL1(gene name synonym)|uniprotkb:CD003(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054455|psi-mi:"MI:0471"|imex:IM-25807-763	author score:7.20	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_056182.2|refseq:XP_011544423.1|ensembl:ENSG00000099968(gene)|ensembl:ENST00000317582(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR026298|interpro:IPR036834|interpro:IPR042398|rcsb pdb:2IPD|dip:DIP-60895N|refseq:NP_001257658.1|refseq:NP_001257659.1|refseq:NP_001257660.1|refseq:XP_016884217.1|refseq:XP_016884218.1|refseq:XP_016884219.1|refseq:XP_016884220.1|refseq:XP_016884221.1|refseq:XP_016884222.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:CTVG9Xyunw/XyOeGX4zYaSXdo6Y9606	rigid:0FEcGPlGrI3807UU4LAVXfQW9tY	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:O95235	intact:EBI-15990239	intact:EBI-2551319|ensembl:ENSP00000378356|uniprotkb:B4DL79|uniprotkb:D3DQB6	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ki20a_human(display_long)|uniprotkb:RAB6KIFL(gene name synonym)|uniprotkb:Rabkinesin-6(gene name synonym)|uniprotkb:Rab6-interacting kinesin-like protein(gene name synonym)|uniprotkb:GG10_2(gene name synonym)|uniprotkb:KIF20A(gene name)|psi-mi:KIF20A(display_short)|uniprotkb:MKLP2(gene name synonym)|uniprotkb:Mitotic kinesin-like protein 2(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054443|psi-mi:"MI:0471"|imex:IM-25807-762	author score:7.12	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027326|interpro:IPR027417|interpro:IPR027640|rcsb pdb:6YIP|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-68884|reactome:R-HSA-983189|ensembl:ENSG00000112984(gene)|ensembl:ENST00000394894(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0045171"(intercellular bridge)|go:"GO:0061952"(midbody abscission)|refseq:NP_005724.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:UEHYcHW3yyIJ98iv4jEC8+wd33M9606	rigid:jFfYlkLULkDWK/21Ffa++TOYQwk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P16144	intact:EBI-15990239	intact:EBI-948678|ensembl:ENSP00000200181|uniprotkb:O14690|uniprotkb:O14691|uniprotkb:O15339|uniprotkb:O15340|uniprotkb:O15341|uniprotkb:Q9UIQ4|uniprotkb:A0AVL6|uniprotkb:Q0VF97	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:itb4_human(display_long)|uniprotkb:GP150(gene name synonym)|uniprotkb:ITGB4(gene name)|psi-mi:ITGB4(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054431|psi-mi:"MI:0471"|imex:IM-25807-761	author score:63.62	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	dip:DIP-40182N|ensembl:ENSG00000132470(gene)|ensembl:ENST00000200181(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009611"(response to wounding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030056"(hemidesmosome)|go:"GO:0031252"(cell leading edge)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035878"(nail development)|go:"GO:0043235"(receptor complex)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048870"(cell motility)|go:"GO:0061450"(trophoblast cell migration)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR003644(Na-Ca exchanger/integrin-beta4)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR012013(Integrin beta-4 subunit)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR033760|interpro:IPR036116|interpro:IPR036349|interpro:IPR036465|interpro:IPR038081|interpro:IPR040622|mint:P16144|rcsb pdb:1QG3|rcsb pdb:2YRZ|rcsb pdb:3F7P|rcsb pdb:3F7Q|rcsb pdb:3F7R|rcsb pdb:3FQ4|rcsb pdb:3FSO|rcsb pdb:3H6A|rcsb pdb:4Q58|rcsb pdb:4WTW|rcsb pdb:4WTX|rcsb pdb:6GVK|rcsb pdb:6GVL|reactome:R-HSA-2022090|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-446107|refseq:NP_000204.3|refseq:NP_001005619.1|refseq:NP_001005731.1|refseq:NP_001308052.1	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:XSzTESyjef5LPBxsph8tWNGJ2u49606	rigid:aLKC44HxmgSGFJ5izt5jtUD7FZ8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9Y570	intact:EBI-15990239	intact:EBI-1772895|uniprotkb:Q8WYG8|uniprotkb:Q9NVT5|uniprotkb:Q9UI18|uniprotkb:B3KMU6|uniprotkb:B5MEE7|uniprotkb:J3QT22|ensembl:ENSP00000329867	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ppme1_human(display_long)|uniprotkb:PPME1(gene name)|psi-mi:PPME1(display_short)|uniprotkb:PME1(gene name synonym)|uniprotkb:PP2593(orf name)|uniprotkb:PRO0750(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054419|psi-mi:"MI:0471"|imex:IM-25807-760	author score:6.68	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057231.1|refseq:NP_001258522.1|ensembl:ENSG00000214517(gene)|ensembl:ENST00000328257(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006482"(protein demethylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051722"(protein C-terminal methylesterase activity)|go:"GO:0051723"(protein methylesterase activity)|interpro:IPR000073(Alpha/beta hydrolase fold-1)|interpro:IPR016812(Protein phosphatase methylesterase, eukaryotic)|interpro:IPR029058|rcsb pdb:3C5V|rcsb pdb:3C5W|reactome:R-HSA-69273	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:ZOIwpvvy8nrnGzuNkEu7AZn0JuA9606	rigid:hcfXzFkFYCu2537MuQX6F5rEo3k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q16236	intact:EBI-15990239	intact:EBI-2007911|uniprotkb:Q53RW6|uniprotkb:Q59HH2|uniprotkb:Q96F71|uniprotkb:B2RBU2|uniprotkb:B4E338|uniprotkb:E9PGJ7|intact:EBI-28978278|ensembl:ENSP00000380252	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nf2l2_human(display_long)|uniprotkb:NFE2L2(gene name)|psi-mi:NFE2L2(display_short)|uniprotkb:NRF2(gene name synonym)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:HEBP1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054407|psi-mi:"MI:0471"|imex:IM-25807-759	author score:6.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	ensembl:ENSP00000380252|ensembl:ENST00000397063|ensembl:ENSP00000380253|ensembl:ENST00000446151|ensembl:ENSP00000411575|ensembl:ENST00000464747|ensembl:ENSP00000467401|refseq:NP_001300829.1|refseq:NP_001300830.1|refseq:NP_001138884.1|refseq:NP_006155.2|refseq:NP_001138885.1|dip:DIP-29971N|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|mint:Q16236|rcsb pdb:2FLU|rcsb pdb:2LZ1|rcsb pdb:3ZGC|rcsb pdb:4IFL|rcsb pdb:5WFV|rcsb pdb:6T7V|reactome:R-HSA-8932339|reactome:R-HSA-9707587|reactome:R-HSA-9707616|ensembl:ENSG00000116044(gene)|ensembl:ENST00000397062(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:EjSeL1dJClhC2vIPip6QDc8QAUk9606	rigid:woXQkw6twZMfMxs6ykpLi81NNXE	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9UJY5	intact:EBI-15990239	intact:EBI-447141|uniprotkb:Q5TG07|uniprotkb:Q9BW94|uniprotkb:Q9UG00|uniprotkb:Q9UGW0|uniprotkb:Q9UGW1|uniprotkb:A8K3D3|uniprotkb:Q5R3N1|uniprotkb:Q6IC75|uniprotkb:B0QYR7|uniprotkb:Q86YA9|uniprotkb:Q8NCS6|ensembl:ENSP00000341344	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:gga1_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 1(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 1(gene name synonym)|uniprotkb:GGA1(gene name)|psi-mi:GGA1(display_short)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054395|psi-mi:"MI:0471"|imex:IM-25807-758	author score:6.10	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001001560.1|refseq:NP_001166158.1|refseq:NP_001166159.1|refseq:NP_037497.1|refseq:XP_005261574.1|refseq:XP_011528424.1|refseq:XP_005261577.1|refseq:XP_006724292.1|refseq:XP_016884249.1|refseq:XP_016884250.1|refseq:XP_016884251.1|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:1901998"(toxin transport)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY5|rcsb pdb:1J2J|rcsb pdb:1JWF|rcsb pdb:1JWG|rcsb pdb:1NA8|rcsb pdb:1NAF|rcsb pdb:1NWM|rcsb pdb:1O3X|rcsb pdb:1OM9|rcsb pdb:1OXZ|rcsb pdb:1PY1|rcsb pdb:1UJJ|rcsb pdb:1UJK|rcsb pdb:1X79|rcsb pdb:2DWX|rcsb pdb:2DWY|rcsb pdb:3G2S|rcsb pdb:3G2T|rcsb pdb:3G2U|rcsb pdb:3G2V|rcsb pdb:3G2W|reactome:R-HSA-8854214|reactome:R-HSA-977225|ensembl:ENSG00000100083(gene)|ensembl:ENST00000343632(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008104"(protein localization)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:3n7Nia4JzMiDja0I7mUcyihFFBc9606	rigid:OkUDnlyp3Iff0nrHddJUAE54J/k	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:P22736	intact:EBI-15990239	intact:EBI-721550|uniprotkb:B4DML7|ensembl:ENSP00000243050|ensembl:ENSP00000378301|ensembl:ENSP00000378302|uniprotkb:Q15627|uniprotkb:Q53Y00|uniprotkb:Q6IBU8	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nr4a1_human(display_long)|uniprotkb:Orphan nuclear receptor HMR(gene name synonym)|uniprotkb:Early response protein NAK1(gene name synonym)|uniprotkb:Orphan nuclear receptor TR3(gene name synonym)|uniprotkb:ST-59(gene name synonym)|uniprotkb:GFRP1(gene name synonym)|uniprotkb:HMR(gene name synonym)|uniprotkb:NAK1(gene name synonym)|uniprotkb:NR4A1(gene name)|psi-mi:NR4A1(display_short)|uniprotkb:Nuclear hormone receptor NUR/77(gene name synonym)|uniprotkb:Testicular receptor 3(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054383|psi-mi:"MI:0471"|imex:IM-25807-757	author score:6.00	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001189162.1|refseq:NP_002126.2|refseq:NP_775180.1|ensembl:ENSG00000123358(gene)|ensembl:ENST00000243050(transcript)|ensembl:ENST00000394824(transcript)|ensembl:ENST00000394825(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|dip:DIP-40392N|refseq:XP_005268881.1|refseq:XP_006719426.1|refseq:XP_006719427.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014860"(neurotransmitter secretion involved in regulation of skeletal muscle contraction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0071376"(cellular response to corticotropin-releasing hormone stimulus)|go:"GO:0098793"(presynapse)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR003070(Orphan nuclear receptor)|interpro:IPR003071(Orphan nuclear receptor, HMR type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P22736|rcsb pdb:2QW4|rcsb pdb:3V3E|rcsb pdb:3V3Q|rcsb pdb:4JGV|rcsb pdb:4KZI|rcsb pdb:4KZJ|rcsb pdb:4KZM|rcsb pdb:4RE8|rcsb pdb:4REE|rcsb pdb:4REF|rcsb pdb:4RZE|rcsb pdb:4RZF|rcsb pdb:4RZG|rcsb pdb:4WHF|rcsb pdb:4WHG|rcsb pdb:6KZ5|rcsb pdb:6LC1|reactome:R-HSA-198693|reactome:R-HSA-383280|reactome:R-HSA-5674400	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:yocf+C94vprIeNXXB89p3tqzW/c9606	rigid:GolUHnFtEF+fBvwpSjXS1S2CVeQ	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q14790	intact:EBI-15990239	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054371|psi-mi:"MI:0471"|imex:IM-25807-756	author score:53.49	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	rigid:M3WDZMz5BFS6azjsAiMQkK8d+G8	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q16629	intact:EBI-15990239	intact:EBI-398885|uniprotkb:Q564D3|intact:EBI-11107979|uniprotkb:B4DLU6|uniprotkb:G5E9M3|ensembl:ENSP00000325905	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:srsf7_human(display_long)|uniprotkb:SRSF7(gene name)|psi-mi:SRSF7(display_short)|uniprotkb:Splicing factor 9G8(gene name synonym)|uniprotkb:SFRS7(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 7(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054359|psi-mi:"MI:0471"|imex:IM-25807-755	author score:5.90	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_001026854.1|refseq:NP_001182375.1|dip:DIP-31790N|ensembl:ENSG00000115875(gene)|ensembl:ENST00000313117(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034651|interpro:IPR035979|interpro:IPR036875|mint:Q16629|rcsb pdb:2HVZ|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72187|reactome:R-HSA-73856	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:12lFDvstcW/ySFKb4LR8KF9AylI9606	rigid:qDnq7XZro2L/LLGNktXRKdAYuEI	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q15365	intact:EBI-15990239	intact:EBI-946095|uniprotkb:Q13157|uniprotkb:Q14975|ensembl:ENSP00000305556	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pcbp1_human(display_long)|uniprotkb:PCBP1(gene name)|psi-mi:PCBP1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Nucleic acid-binding protein SUB2.3(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054347|psi-mi:"MI:0471"|imex:IM-25807-754	author score:5.59	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_006187.2|dip:DIP-38136N|ensembl:ENSG00000169564(gene)|ensembl:ENST00000303577(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q15365|rcsb pdb:1WVN|rcsb pdb:1ZTG|rcsb pdb:3VKE|reactome:R-HSA-72163|reactome:R-HSA-72203	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:x72fawo4plQ+ipfqIoREIDHc2bA9606	rigid:UIF9MBacwp5J4cayHxuJMf2R/3A	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9UHY1	intact:EBI-15990239	intact:EBI-749731|uniprotkb:Q53FZ5|uniprotkb:Q96SU3|uniprotkb:B3KV40|uniprotkb:D6W558|ensembl:ENSP00000233557|ensembl:ENSP00000369181	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:nrbp_human(display_long)|uniprotkb:NRBP1(gene name)|psi-mi:NRBP1(display_short)|uniprotkb:BCON3(gene name synonym)|uniprotkb:NRBP(gene name synonym)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054335|psi-mi:"MI:0471"|imex:IM-25807-753	author score:5.51	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_037524.1|refseq:NP_001308286.1|refseq:NP_001308287.1|refseq:NP_001308288.1|refseq:NP_001308290.1|refseq:NP_001308291.1|refseq:NP_001308292.1|ensembl:ENSG00000115216(gene)|ensembl:ENST00000233557(transcript)|ensembl:ENST00000379852(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR011009(Protein kinase-like)|reactome:R-HSA-383280	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:goSncKy0TZmmVuw5UPUDsCiAzkk9606	rigid:PEUHVCahgT/stUV7wI0c7HGxwbA	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36778	uniprotkb:Q9Y244	intact:EBI-15990239	intact:EBI-696895|uniprotkb:A5HKJ2|uniprotkb:Q9HB69|uniprotkb:D6MXU3|ensembl:ENSP00000370222	psi-mi:ve2_hpv03(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:pomp_human(display_long)|uniprotkb:Proteassemblin(gene name synonym)|uniprotkb:Protein UMP1 homolog(gene name synonym)|uniprotkb:Voltage-gated K channel beta subunit 4.1(gene name synonym)|uniprotkb:POMP(gene name)|psi-mi:POMP(display_short)|uniprotkb:C13orf12(gene name synonym)|uniprotkb:UMP1(gene name synonym)|uniprotkb:HSPC014(orf name)|uniprotkb:HSPC036(orf name)|uniprotkb:PNAS-110(orf name)	psi-mi:"MI:1203"(split luciferase complementation)	Muller et al. (2011)	pubmed:22761572|imex:IM-25807|doi:10.1371/journal.ppat.1002761	taxid:10614(hpv03)|taxid:10614(Human papillomavirus type 3)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-16054323|psi-mi:"MI:0471"|imex:IM-25807-752	author score:5.08	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR042503|interpro:IPR042504|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050	refseq:NP_057016.1|ensembl:ENSG00000132963(gene)|ensembl:ENST00000380842(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0043248"(proteasome assembly)|interpro:IPR008012(Proteasome maturation factor UMP1)|mint:Q9Y244	-	-	-	figure legend:ST4 ST5 F2A F3A|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2017/01/19	2017/08/10	rogid:8u5TRRY6cvIfueMSDsyb8ILJpIM10614	rogid:m+0wD07fgD7iQF8cB1rqhIIWLxk9606	rigid:Fe8JO8M4nlKwMul0+9alWwZ1mWk	false	gaussia-c:?-?("MI:2220")	gaussia-n:?-?("MI:2221")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)