#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05155	uniprotkb:O82882	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-15979286|ensemblbacteria:AAC70099|ensemblbacteria:BAA31757|uniprotkb:Q647K0|uniprotkb:Q799Q8|uniprotkb:Q7BSW2|uniprotkb:Q9ZAL1|uniprotkb:Q9ZGU1	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:stce_eco57(display_long)|uniprotkb:stcE(gene name)|psi-mi:stcE(display_short)|uniprotkb:tagA(gene name synonym)|uniprotkb:L7031(locus name)|uniprotkb:ECO57PM83(locus name)|uniprotkb:Mucinase(gene name synonym)|uniprotkb:Neutral zinc metalloprotease StcE(gene name synonym)|uniprotkb:Secreted protease of C1 esterase inhibitor from EHEC(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Yu et al. (2012)	pubmed:22483117|doi:10.1016/j.str.2012.02.015|imex:IM-17603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15979313|imex:IM-17603-1|dip:DIP-188905E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	ensemblbacteria:AAC70099(transcript)|ensemblbacteria:BAA31757(gene)|ensemblbacteria:BAA31757(transcript)|ensemblbacteria:Z_L7031(gene)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|interpro:IPR019503|interpro:IPR022218|interpro:IPR040966|rcsb pdb:3UJZ|rcsb pdb:4DNY|refseq:NP_052607.1|refseq:WP_001358886.1|refseq:YP_001294684.1|dip:DIP-59647N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:RJmoeTTpG+mJ34SKpzdZ/bsCB9Y83334	rigid:QN4ss8wuorvZymAjY3WlmBfEnp8	false	-	sufficient binding region:36-898	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05155	uniprotkb:O82882	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-15979286|ensemblbacteria:AAC70099|ensemblbacteria:BAA31757|uniprotkb:Q647K0|uniprotkb:Q799Q8|uniprotkb:Q7BSW2|uniprotkb:Q9ZAL1|uniprotkb:Q9ZGU1	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:stce_eco57(display_long)|uniprotkb:stcE(gene name)|psi-mi:stcE(display_short)|uniprotkb:tagA(gene name synonym)|uniprotkb:L7031(locus name)|uniprotkb:ECO57PM83(locus name)|uniprotkb:Mucinase(gene name synonym)|uniprotkb:Neutral zinc metalloprotease StcE(gene name synonym)|uniprotkb:Secreted protease of C1 esterase inhibitor from EHEC(gene name synonym)	psi-mi:"MI:0104"(static light scattering)	Yu et al. (2012)	pubmed:22483117|doi:10.1016/j.str.2012.02.015|imex:IM-17603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15979332|imex:IM-17603-2|dip:DIP-188905E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	ensemblbacteria:AAC70099(transcript)|ensemblbacteria:BAA31757(gene)|ensemblbacteria:BAA31757(transcript)|ensemblbacteria:Z_L7031(gene)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|interpro:IPR019503|interpro:IPR022218|interpro:IPR040966|rcsb pdb:3UJZ|rcsb pdb:4DNY|refseq:NP_052607.1|refseq:WP_001358886.1|refseq:YP_001294684.1|dip:DIP-59647N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:RJmoeTTpG+mJ34SKpzdZ/bsCB9Y83334	rigid:QN4ss8wuorvZymAjY3WlmBfEnp8	false	-	sufficient binding region:36-898	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05155	uniprotkb:O82882	intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807	intact:EBI-15979286|ensemblbacteria:AAC70099|ensemblbacteria:BAA31757|uniprotkb:Q647K0|uniprotkb:Q799Q8|uniprotkb:Q7BSW2|uniprotkb:Q9ZAL1|uniprotkb:Q9ZGU1	psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym)	psi-mi:stce_eco57(display_long)|uniprotkb:stcE(gene name)|psi-mi:stcE(display_short)|uniprotkb:tagA(gene name synonym)|uniprotkb:L7031(locus name)|uniprotkb:ECO57PM83(locus name)|uniprotkb:Mucinase(gene name synonym)|uniprotkb:Neutral zinc metalloprotease StcE(gene name synonym)|uniprotkb:Secreted protease of C1 esterase inhibitor from EHEC(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Yu et al. (2012)	pubmed:22483117|doi:10.1016/j.str.2012.02.015|imex:IM-17603	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:83334(eco57)|taxid:83334("Escherichia coli O157:H7")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0465"(DIP)	intact:EBI-15979351|imex:IM-17603-3|dip:DIP-188905E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606	ensemblbacteria:AAC70099(transcript)|ensemblbacteria:BAA31757(gene)|ensemblbacteria:BAA31757(transcript)|ensemblbacteria:Z_L7031(gene)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0046872"(metal ion binding)|interpro:IPR019503|interpro:IPR022218|interpro:IPR040966|rcsb pdb:3UJZ|rcsb pdb:4DNY|refseq:NP_052607.1|refseq:WP_001358886.1|refseq:YP_001294684.1|dip:DIP-59647N	psi-mi:"MI:0465"(dip)	-	-	comment:Deletion of region 140-243 decreased the interaction rate/strength.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606	rogid:RJmoeTTpG+mJ34SKpzdZ/bsCB9Y83334	rigid:QN4ss8wuorvZymAjY3WlmBfEnp8	false	-	sufficient binding region:36-898	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)