#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13415	uniprotkb:O43913	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374928|uniprotkb:O60590|ensembl:ENSP00000297431|uniprotkb:A4D0P8|uniprotkb:O95268	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc5_human(display_long)|uniprotkb:ORC5(gene name)|psi-mi:ORC5(display_short)|uniprotkb:ORC5L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973221|imex:IM-17648-1|dip:DIP-188984E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	refseq:NP_859531.1|ensembl:ENSG00000164815(gene)|ensembl:ENST00000297431(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|interpro:IPR020796|interpro:IPR027417|interpro:IPR041664|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|go:"GO:0000785"(chromatin)|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_002544.1|dip:DIP-29691N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:cEPmtzna+N3Gh52gm0VdS9xqfhA9606	rigid:uokETIPHq5ox2mBCf3JqvOrFxhE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:Q9UBD5	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973221|imex:IM-17648-1|dip:DIP-188984E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	rigid:uokETIPHq5ox2mBCf3JqvOrFxhE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13415	uniprotkb:Q13416	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	intact:EBI-374957|uniprotkb:Q13204|uniprotkb:Q53TX5|ensembl:ENSP00000234296	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:orc2_human(display_long)|uniprotkb:ORC2(gene name)|psi-mi:ORC2(display_short)|uniprotkb:ORC2L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973221|imex:IM-17648-1|dip:DIP-188984E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	ensembl:ENSG00000115942(gene)|ensembl:ENST00000234296(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0000808"(origin recognition complex)|go:"GO:0000939"(inner kinetochore)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|interpro:IPR007220(Origin recognition complex subunit 2)|mint:Q13416|rcsb pdb:5C8H|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|refseq:NP_006181.1|rcsb pdb:7JPP|rcsb pdb:7JPQ|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:XP_006712618.1|dip:DIP-29689N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rogid:tnmEVmoakf7BB10oSJlvrP5ioYM9606	rigid:uokETIPHq5ox2mBCf3JqvOrFxhE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q58DC8	intact:EBI-15973242	intact:EBI-15973366|uniprotkb:A2VDN4	dip:DIP-59666N	psi-mi:orc1_bovin(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973387|imex:IM-17648-5|dip:DIP-188987E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR043151|interpro:IPR041083|refseq:XP_015320898.1|refseq:NP_001014918.1|dip:DIP-59665N	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:GbKa0RzMuSmj/61nVdhxZLSx0xQ9913	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:a3v1oKwkO4kP9BgRyPXdXXYWkls	false	sufficient binding region:45-171|glutathione s tranferase tag:n-n	biotin tag:?-?|N6,N6-dimethyl-L-lysine:10-10|N6,N6,N6-trimethyl-L-lysine:10-10	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z1N2	intact:EBI-15973242	intact:EBI-773812|uniprotkb:A2A8R3|ensembl:ENSMUSP00000099805	dip:DIP-59666N	psi-mi:orc1_mouse(display_long)|uniprotkb:Orc1(gene name)|psi-mi:Orc1(display_short)|uniprotkb:Orc1l(gene name synonym)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973322|imex:IM-17648-4|dip:DIP-188986E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_035145.2|dip:DIP-32115N|ensembl:ENSMUSG00000028587(gene)|ensembl:ENSMUST00000102744(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:4DOV|rcsb pdb:4DOW|reactome:R-MMU-176187|reactome:R-MMU-68616|reactome:R-MMU-68689|reactome:R-MMU-68827|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:GY+oDJsPg1kc/AoUsBFnaLIBUO010090	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:8Wh3BKyTZwRImqwuQ/Off6Nhfj0	false	sufficient binding region:9-170|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:63-63|mutation disrupting interaction strength:87-87|mutation disrupting interaction strength:93-93|mutation disrupting interaction strength:119-119	N6,N6-dimethyl-L-lysine:10-10|biotin tag:?-?|N6-methyl-L-lysine:10-10|N6,N6,N6-trimethyl-L-lysine:10-10	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O16810	intact:EBI-15973242	intact:EBI-90907|uniprotkb:Q9V4N1|ensemblmetazoa:FBpp0088033	dip:DIP-59666N	psi-mi:orc1_drome(display_long)|uniprotkb:Orc1(gene name)|psi-mi:Orc1(display_short)|uniprotkb:CG10667(orf name)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973294|imex:IM-17648-3|dip:DIP-188990E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_477303.1|ensemblmetazoa:FBtr0088959(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006277"(DNA amplification)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|ensemblmetazoa:FBgn0286788(gene)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:4XGC|rcsb pdb:7JGR|rcsb pdb:7JK2|rcsb pdb:7JK3|rcsb pdb:7JK4|rcsb pdb:7JK5|rcsb pdb:7JK6|reactome:R-DME-176187|reactome:R-DME-68616|reactome:R-DME-68689|reactome:R-DME-68827|reactome:R-DME-68867|reactome:R-DME-68949|reactome:R-DME-68962|rcsb pdb:7JGS|flybase:FBgn0286788|dip:DIP-59662N	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:7pWy0a1ZJ4cfDIPw9aPU0AZh3MQ7227	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:slTDcEcVFak99lFhf6B0F52zIzY	false	sufficient binding region:45-187|glutathione s tranferase tag:n-n	N6,N6-dimethyl-L-lysine:10-10|biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-15973242	uniprotkb:Q13415	dip:DIP-59666N	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973246|imex:IM-17648-2|dip:DIP-188985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rigid:JCFet2GsRdD4PZf64EcjmJIGIsM	false	N6,N6-dimethyl-L-lysine:10-10|sufficient binding region:4-15	sufficient binding region:1-185|mutation disrupting interaction strength:64-64|mutation disrupting interaction strength:88-88|mutation decreasing interaction strength:94-94|mutation decreasing interaction strength:115-115|mutation decreasing interaction strength:90-90|mutation decreasing interaction strength:89-89|mutation decreasing interaction strength:127-127|mutation decreasing interaction strength:120-120	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Z1N2	intact:EBI-15973242	intact:EBI-773812|uniprotkb:A2A8R3|ensembl:ENSMUSP00000099805	dip:DIP-59666N	psi-mi:orc1_mouse(display_long)|uniprotkb:Orc1(gene name)|psi-mi:Orc1(display_short)|uniprotkb:Orc1l(gene name synonym)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973566|imex:IM-17648-10|dip:DIP-188986E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_035145.2|dip:DIP-32115N|ensembl:ENSMUSG00000028587(gene)|ensembl:ENSMUST00000102744(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:4DOV|rcsb pdb:4DOW|reactome:R-MMU-176187|reactome:R-MMU-68616|reactome:R-MMU-68689|reactome:R-MMU-68827|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:GY+oDJsPg1kc/AoUsBFnaLIBUO010090	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:8Wh3BKyTZwRImqwuQ/Off6Nhfj0	false	sufficient binding region:9-170	N6,N6-dimethyl-L-lysine:10-10|sufficient binding region:4-15	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q7ZYW6	intact:EBI-15973242	intact:EBI-15973521	dip:DIP-59666N	psi-mi:q7zyw6_danre(display_long)|uniprotkb:orc1(gene name)|psi-mi:orc1(display_short)|uniprotkb:orc1l(gene name synonym)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:7955(danre)|taxid:7955("Danio rerio (Zebrafish)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973539|imex:IM-17648-9|dip:DIP-188989E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	go:"GO:0001878"(response to yeast)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0060271"(cilium assembly)|interpro:IPR041083|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR027417|refseq:NP_956227.1|interpro:IPR020793|interpro:IPR043151	-	psi-mi:"MI:0465"(dip)	crc64:5A813B2B2A6E196D	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:lJIXMA5YkebYSKAxdoZ674xlr107955	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:v3FE77IvIr0g/S8jeYAIyy8yKfs	false	sufficient binding region:44-166|glutathione s tranferase tag:n-n	N6,N6-dimethyl-L-lysine:10-10|biotin tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-15973242	uniprotkb:Q13415	dip:DIP-59666N	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973477|imex:IM-17648-8|dip:DIP-188985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rigid:JCFet2GsRdD4PZf64EcjmJIGIsM	false	N6,N6-dimethyl-L-lysine:10-10|biotin tag:?-?	sufficient binding region:1-185|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:64-64|mutation disrupting interaction strength:88-88|mutation disrupting interaction strength:94-94|mutation disrupting interaction strength:120-120|mutation decreasing interaction strength:89-89|mutation decreasing interaction strength:127-127	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62803	uniprotkb:Q13415	intact:EBI-7694010|ensembl:ENSBTAP00000047761|ensembl:ENSBTAP00000052235|ensembl:ENSBTAP00000053034|ensembl:ENSBTAP00000062765|ensembl:ENSBTAP00000067077|uniprotkb:P02304|uniprotkb:P02305|uniprotkb:A5PK53|intact:UNK-6045289|uniprotkb:A5PJ80|uniprotkb:A8QFF4	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:h4_bovin(display_long)|uniprotkb:H4.1(gene name synonym)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973445|imex:IM-17648-7|dip:DIP-188991E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000040277(gene)|ensembl:ENSBTAG00000052332(gene)|ensembl:ENSBTAG00000052349(gene)|ensembl:ENSBTAG00000052609(gene)|ensembl:ENSBTAG00000053034(gene)|ensembl:ENSBTAT00000052402(transcript)|ensembl:ENSBTAT00000054510(transcript)|ensembl:ENSBTAT00000056505(transcript)|ensembl:ENSBTAT00000068837(transcript)|ensembl:ENSBTAT00000072717(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR001951(Histone H4)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR019809|interpro:IPR035425|mint:P62803|reactome:R-BTA-110330|reactome:R-BTA-110331|reactome:R-BTA-201722|reactome:R-BTA-212300|reactome:R-BTA-2299718|reactome:R-BTA-2559580|reactome:R-BTA-3214815|reactome:R-BTA-3214841|reactome:R-BTA-3214842|reactome:R-BTA-3214847|reactome:R-BTA-3214858|reactome:R-BTA-427359|reactome:R-BTA-427413|reactome:R-BTA-5250924|reactome:R-BTA-5693565|reactome:R-BTA-606279|reactome:R-BTA-73728|reactome:R-BTA-8936459|reactome:R-BTA-9018519|reactome:R-BTA-9670095|refseq:XP_002684676.1|refseq:NP_001093194.1|refseq:NP_001139343.1|refseq:NP_776305.1|refseq:XP_874074.1|refseq:XP_605163.2|refseq:XP_002697516.1|dip:DIP-44668N	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	psi-mi:"MI:0465"(dip)	function:Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling|comment:mint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:LZSfhrpw0PcDREEoJ1UMkBvnUfA9913	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rigid:HTlu8s0PEO0kE96xnehSFDjnCAg	false	N6,N6-dimethyl-L-lysine:21-21	sufficient binding region:1-185|glutathione s tranferase tag:n-n|mutation disrupting interaction strength:64-64|mutation disrupting interaction strength:88-88|mutation disrupting interaction strength:94-94	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
intact:EBI-15973242	uniprotkb:Q13415	dip:DIP-59666N	intact:EBI-374847|uniprotkb:Q13471|uniprotkb:Q5T0F5|ensembl:ENSP00000360621|ensembl:ENSP00000360623|uniprotkb:D3DQ34	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:orc1_human(display_long)|uniprotkb:ORC1(gene name)|psi-mi:ORC1(display_short)|uniprotkb:ORC1L(gene name synonym)|uniprotkb:PARC1(gene name synonym)|uniprotkb:Replication control protein 1(gene name synonym)	psi-mi:"MI:0892"(solid phase assay)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973589|imex:IM-17648-11|dip:DIP-188985E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000085840(gene)|ensembl:ENST00000371566(transcript)|ensembl:ENST00000371568(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|mint:Q13415|rcsb pdb:5UJ7|rcsb pdb:5UJM|rcsb pdb:6P3W|rcsb pdb:7CTF|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPR|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|refseq:NP_001177747.1|refseq:NP_001177748.1|refseq:NP_004144.2|dip:DIP-29688N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rogid:I6knhXEuT6YwDSFoH5oLh8rpCT89606	rigid:JCFet2GsRdD4PZf64EcjmJIGIsM	false	N6,N6-dimethyl-L-lysine:10-10|biotin tag:?-?	sufficient binding region:1-185|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70049	intact:EBI-15973242	intact:EBI-3645583	dip:DIP-59666N	psi-mi:p70049_xenla(display_long)|uniprotkb:orc1(gene name synonym)|uniprotkb:orc1.L(gene name)|psi-mi:orc1.L(display_short)|uniprotkb:XORC1(gene name synonym)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0096"(pull down)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973416|imex:IM-17648-6|dip:DIP-188988E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006260"(DNA replication)|interpro:IPR020793|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR015163(CDC6, C terminal)|refseq:NP_001081806.1|interpro:IPR043151|interpro:IPR027417|interpro:IPR041083	-	psi-mi:"MI:0465"(dip)	crc64:6B449D9733487219	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:MlcWR0S7QtLUkz3HCpzuZbCzZCA8355	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:5Wi0NHQ20Ez4cXd6Q00ikv9upI0	false	sufficient binding region:44-169|glutathione s tranferase tag:n-n	biotin tag:?-?|N6,N6-dimethyl-L-lysine:10-10|N6-methyl-L-lysine:10-10	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z1N2	intact:EBI-15973242	intact:EBI-773812|uniprotkb:A2A8R3|ensembl:ENSMUSP00000099805	dip:DIP-59666N	psi-mi:orc1_mouse(display_long)|uniprotkb:Orc1(gene name)|psi-mi:Orc1(display_short)|uniprotkb:Orc1l(gene name synonym)	psi-mi:"h4(1129)"(display_short)|psi-mi:EBI-15973242(display_long)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Kuo et al. (2012)	pubmed:22398447|doi:10.1038/nature10956|imex:IM-17648	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15973615|imex:IM-17648-12|dip:DIP-188986E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_035145.2|dip:DIP-32115N|ensembl:ENSMUSG00000028587(gene)|ensembl:ENSMUST00000102744(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000808"(origin recognition complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:4DOV|rcsb pdb:4DOW|reactome:R-MMU-176187|reactome:R-MMU-68616|reactome:R-MMU-68689|reactome:R-MMU-68827|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/10	rogid:GY+oDJsPg1kc/AoUsBFnaLIBUO010090	rogid:4Ubxqhbtl57jDoUscJcC4cXnFKQ-2	rigid:8Wh3BKyTZwRImqwuQ/Off6Nhfj0	false	sufficient binding region:9-170	N6,N6-dimethyl-L-lysine:10-10|sufficient binding region:4-15|N6-methyl-L-lysine:10-10|N6,N6,N6-trimethyl-L-lysine:10-10	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)