#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O76064-1	uniprotkb:P13010	intact:EBI-15964690|ensembl:ENSP00000362578	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964700|imex:IM-18082-2|dip:DIP-189774E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rigid:fknAG/wleOl7PX6Y7j7UlXmEqzI	false	necessary binding region:38-92|s tag:n-n|flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IYW5	intact:EBI-4399559	intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898	dip:DIP-24261N	psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964669|imex:IM-18082-1|dip:DIP-65427E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:zgESqo4Ki+X7r5LHOdqmYvW6QVk	false	flag tag:n-n	his tag:0-0	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O96017	uniprotkb:O76064-1	intact:EBI-1180783|uniprotkb:Q6QA03|uniprotkb:Q6QA04|uniprotkb:Q6QA05|uniprotkb:Q6QA06|uniprotkb:Q6QA07|uniprotkb:Q6QA08|uniprotkb:Q6QA10|uniprotkb:Q6QA11|uniprotkb:Q6QA12|uniprotkb:Q6QA13|uniprotkb:Q9HCQ8|uniprotkb:Q9UGF0|uniprotkb:Q9UGF1|uniprotkb:B7ZBF3|uniprotkb:B7ZBF4|uniprotkb:B7ZBF5|uniprotkb:Q9HBS5|uniprotkb:A8K3Y9|ensembl:ENSP00000385747|ensembl:ENSP00000386087|ensembl:ENSP00000497000	intact:EBI-15964690|ensembl:ENSP00000362578	psi-mi:chk2_human(display_long)|uniprotkb:CHEK2(gene name)|psi-mi:CHEK2(display_short)|uniprotkb:CHK2(gene name synonym)|uniprotkb:RAD53(gene name synonym)|uniprotkb:Cds1 homolog(gene name synonym)|uniprotkb:Checkpoint kinase 2(gene name synonym)|uniprotkb:CDS1(gene name synonym)|uniprotkb:CHK2 checkpoint homolog(gene name synonym)	psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964766|imex:IM-18082-5|dip:DIP-189776E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_016884050.1|refseq:NP_001005735.1|refseq:NP_009125.1|refseq:NP_665861.1|refseq:NP_001244316.1|refseq:XP_011528147.1|dip:DIP-24270N|ensembl:ENSG00000183765(gene)|ensembl:ENST00000404276(transcript)|ensembl:ENST00000405598(transcript)|ensembl:ENST00000650281(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035690"|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044773"(mitotic DNA damage checkpoint signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1903416"(response to glycoside)|go:"GO:1903926"(cellular response to bisphenol A)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|mint:O96017|rcsb pdb:1GXC|rcsb pdb:2CN5|rcsb pdb:2CN8|rcsb pdb:2W0J|go:"GO:0090399"(replicative senescence)|rcsb pdb:2W7X|rcsb pdb:2WTC|rcsb pdb:2WTD|rcsb pdb:2XM8|rcsb pdb:2XM9|rcsb pdb:2YCF|rcsb pdb:2YCQ|rcsb pdb:2YCR|rcsb pdb:2YCS|rcsb pdb:2YIQ|rcsb pdb:2YIR|rcsb pdb:2YIT|rcsb pdb:3I6U|rcsb pdb:3I6W|rcsb pdb:3VA4|rcsb pdb:4A9R|rcsb pdb:4A9S|rcsb pdb:4A9T|rcsb pdb:4A9U|rcsb pdb:4BDA|rcsb pdb:4BDB|rcsb pdb:4BDC|rcsb pdb:4BDD|rcsb pdb:4BDE|rcsb pdb:4BDF|rcsb pdb:4BDG|rcsb pdb:4BDH|rcsb pdb:4BDI|rcsb pdb:4BDJ|rcsb pdb:4BDK|reactome:R-HSA-5693565|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75035|rcsb pdb:2WTI|rcsb pdb:2WTJ|rcsb pdb:2XBJ|rcsb pdb:2XK9	ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/10	rogid:LaDEJtqjPoEJZoj1f6vlZiiaZoI9606	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	rigid:y4DrL3D0BJHKBWzwLBkyQ1UCdbs	false	ha tag:n-n	necessary binding region:38-92|s tag:n-n|flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P13010	intact:EBI-4399559	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	dip:DIP-24261N	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964792|imex:IM-18082-6|dip:DIP-189773E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:z2YjPJ2I0INTr1G9knxYWmkojZA	false	flag tag:n-n	his tag:0-0	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-4399559	uniprotkb:O96017	dip:DIP-24261N	intact:EBI-1180783|uniprotkb:Q6QA03|uniprotkb:Q6QA04|uniprotkb:Q6QA05|uniprotkb:Q6QA06|uniprotkb:Q6QA07|uniprotkb:Q6QA08|uniprotkb:Q6QA10|uniprotkb:Q6QA11|uniprotkb:Q6QA12|uniprotkb:Q6QA13|uniprotkb:Q9HCQ8|uniprotkb:Q9UGF0|uniprotkb:Q9UGF1|uniprotkb:B7ZBF3|uniprotkb:B7ZBF4|uniprotkb:B7ZBF5|uniprotkb:Q9HBS5|uniprotkb:A8K3Y9|ensembl:ENSP00000385747|ensembl:ENSP00000386087|ensembl:ENSP00000497000	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:chk2_human(display_long)|uniprotkb:CHEK2(gene name)|psi-mi:CHEK2(display_short)|uniprotkb:CHK2(gene name synonym)|uniprotkb:RAD53(gene name synonym)|uniprotkb:Cds1 homolog(gene name synonym)|uniprotkb:Checkpoint kinase 2(gene name synonym)|uniprotkb:CDS1(gene name synonym)|uniprotkb:CHK2 checkpoint homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964745|imex:IM-18082-4|dip:DIP-189777E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	refseq:XP_016884050.1|refseq:NP_001005735.1|refseq:NP_009125.1|refseq:NP_665861.1|refseq:NP_001244316.1|refseq:XP_011528147.1|dip:DIP-24270N|ensembl:ENSG00000183765(gene)|ensembl:ENST00000404276(transcript)|ensembl:ENST00000405598(transcript)|ensembl:ENST00000650281(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035690"|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044773"(mitotic DNA damage checkpoint signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1903416"(response to glycoside)|go:"GO:1903926"(cellular response to bisphenol A)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011009(Protein kinase-like)|mint:O96017|rcsb pdb:1GXC|rcsb pdb:2CN5|rcsb pdb:2CN8|rcsb pdb:2W0J|go:"GO:0090399"(replicative senescence)|rcsb pdb:2W7X|rcsb pdb:2WTC|rcsb pdb:2WTD|rcsb pdb:2XM8|rcsb pdb:2XM9|rcsb pdb:2YCF|rcsb pdb:2YCQ|rcsb pdb:2YCR|rcsb pdb:2YCS|rcsb pdb:2YIQ|rcsb pdb:2YIR|rcsb pdb:2YIT|rcsb pdb:3I6U|rcsb pdb:3I6W|rcsb pdb:3VA4|rcsb pdb:4A9R|rcsb pdb:4A9S|rcsb pdb:4A9T|rcsb pdb:4A9U|rcsb pdb:4BDA|rcsb pdb:4BDB|rcsb pdb:4BDC|rcsb pdb:4BDD|rcsb pdb:4BDE|rcsb pdb:4BDF|rcsb pdb:4BDG|rcsb pdb:4BDH|rcsb pdb:4BDI|rcsb pdb:4BDJ|rcsb pdb:4BDK|reactome:R-HSA-5693565|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-69473|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75035|rcsb pdb:2WTI|rcsb pdb:2WTJ|rcsb pdb:2XBJ|rcsb pdb:2XK9	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:LaDEJtqjPoEJZoj1f6vlZiiaZoI9606	rigid:eJCwBpflzwmTboMS41Wuc8A+Xzo	false	his tag:0-0	ha tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-4399559	uniprotkb:Q8IYW5	dip:DIP-24261N	intact:EBI-914207|uniprotkb:Q8NA67|uniprotkb:Q96NS4|intact:EBI-28968912|ensembl:ENSP00000320898	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:rn168_human(display_long)|uniprotkb:RNF168(gene name)|psi-mi:RNF168(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF168(gene name synonym)|uniprotkb:RING finger protein 168(gene name synonym)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964724|imex:IM-18082-3|dip:DIP-65427E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|ensembl:ENSG00000163961(gene)|ensembl:ENST00000318037(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036351"(histone H2A-K13 ubiquitination)|go:"GO:0036352"(histone H2A-K15 ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045190"(isotype switching)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070535"(histone H2A K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034725|mint:Q8IYW5|rcsb pdb:3L11|rcsb pdb:4GB0|rcsb pdb:5XIS|rcsb pdb:5XIT|rcsb pdb:5XIU|rcsb pdb:5YDK|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|ensembl:ENSP00000320898|refseq:NP_689830.2|dip:DIP-37451N	psi-mi:"MI:0465"(dip)	no-uniprot-update:	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/07	2017/08/15	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rogid:FTUGOdIMWBYvqjBfeyEsFKJsQtc9606	rigid:zgESqo4Ki+X7r5LHOdqmYvW6QVk	false	-	sufficient binding region:100-500|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O76064-1	intact:EBI-4399559	intact:EBI-15964690|ensembl:ENSP00000362578	dip:DIP-24261N	psi-mi:o76064-1(display_long)|uniprotkb:RNF8(gene name)|psi-mi:RNF8(display_short)|uniprotkb:KIAA0646(gene name synonym)|uniprotkb:RING finger protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF8(gene name synonym)	psi-mi:ubiq_human(display_short)|psi-mi:EBI-4399559(display_long)	psi-mi:"MI:0096"(pull down)	Feng et al. (2012)	pubmed:22266820|doi:10.1038/nsmb.2211|imex:IM-18082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15964813|imex:IM-18082-7|dip:DIP-189775E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112130(gene)|ensembl:ENST00000373479(transcript)|intact:EBI-373337(isoform-parent)	uniprotkb:UBIQ_HUMAN(see-also)|refseq:NP_066289.2	psi-mi:"MI:0465"(dip)	-	no-uniprot-update:	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/07	2017/08/15	rogid:nsYlZhRT5wsltOEjHh1l815IphQ9606	rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM9606	rigid:rAjhak7cxZ+ToxU4+7HH0w/F4VQ	false	flag tag:n-n	his tag:0-0	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)