#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8N3Y1-2 uniprotkb:O14737 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-712290|ensembl:ENSP00000466214|uniprotkb:Q53YC9|uniprotkb:Q6IB70|uniprotkb:B4DE64 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:pdcd5_human(display_long)|uniprotkb:TF-1 cell apoptosis-related protein 19(gene name synonym)|uniprotkb:PDCD5(gene name)|psi-mi:PDCD5(display_short)|uniprotkb:TFAR19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) go:"GO:0010698"(acetyltransferase activator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1903638"(positive regulation of protein insertion into mitochondrial outer membrane)|go:"GO:1903645"(negative regulation of chaperone-mediated protein folding)|mint:O14737|rcsb pdb:1YYB|rcsb pdb:2CRU|rcsb pdb:2K6B|interpro:IPR002836(DNA-binding TFAR19-related protein)|interpro:IPR036883|ensembl:ENSG00000105185(gene)|ensembl:ENST00000590247(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_004699.1|refseq:XP_005259449.1|dip:DIP-50602N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:K2DZzTWT7H8gGATfyR72aXDu5qc9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q15645 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-358993|uniprotkb:C9K0T3|uniprotkb:O15324|ensembl:ENSP00000166345|uniprotkb:D3DTC0 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:pch2_human(display_long)|uniprotkb:TRIP13(gene name)|psi-mi:TRIP13(display_short)|uniprotkb:Thyroid receptor-interacting protein 13(gene name synonym)|uniprotkb:PCH2(gene name synonym)|uniprotkb:Thyroid hormone receptor interactor 13(gene name synonym)|uniprotkb:Human papillomavirus type 16 E1 protein-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_004228.1|ensembl:ENSG00000071539(gene)|ensembl:ENST00000166345(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_011512465.1|dip:DIP-34493N|go:"GO:0005694"(chromosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048477"(oogenesis)|go:"GO:0051598"(meiotic recombination checkpoint signaling)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR044539|mint:Q15645|rcsb pdb:5VQ9|rcsb pdb:5VQA|rcsb pdb:5WC2|rcsb pdb:6F0X|rcsb pdb:6LK0|rcsb pdb:7L9P psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:heF2f3R2lGIpZ80mZHnhMktXTE49606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:P84077 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-447171|uniprotkb:P10947|uniprotkb:P32889|ensembl:ENSP00000272102|ensembl:ENSP00000440005|ensembl:ENSP00000442980 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:arf1_human(display_long)|uniprotkb:ARF1(gene name)|psi-mi:ARF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_001019397.1|refseq:NP_001019398.1|refseq:NP_001019399.1|refseq:NP_001649.1|dip:DIP-31597N|ensembl:ENSG00000143761(gene)|ensembl:ENST00000272102(transcript)|ensembl:ENST00000540651(transcript)|ensembl:ENST00000541182(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0043005"(neuron projection)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0055108"(Golgi to transport vesicle transport)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070142"(synaptic vesicle budding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097212"(lysosomal membrane organization)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:1902824"(positive regulation of late endosome to lysosome transport)|go:"GO:0034379"(very-low-density lipoprotein particle assembly)|go:"GO:1903725"(regulation of phospholipid metabolic process)|go:"GO:1990386"(mitotic cleavage furrow ingression)|go:"GO:1990583"(phospholipase D activator activity)|interpro:IPR005225(Small GTP-binding protein)|go:"GO:1902953"(positive regulation of ER to Golgi vesicle-mediated transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P84077|rcsb pdb:1HUR|rcsb pdb:1RE0|rcsb pdb:1U81|rcsb pdb:3O47|rcsb pdb:4HMY|rcsb pdb:6CM9|rcsb pdb:6CRI|rcsb pdb:6D83|rcsb pdb:6D84|rcsb pdb:6DFF|rcsb pdb:6FAE|rcsb pdb:7MGE|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-167590|reactome:R-HSA-199992|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-8950505 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:zray9asm6VonxpuJpv0dRBspPt89606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:O75147 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-1223896|uniprotkb:A4KVA5|uniprotkb:Q96IW3|intact:EBI-7903201|intact:MINT-8415345|uniprotkb:A4KVA4|uniprotkb:S4R3M6|intact:EBI-28983679|ensembl:ENSP00000385636|uniprotkb:A0A024R468 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:obsl1_human(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_001166879.1|refseq:NP_056126.1|refseq:NP_001166902.1|ensembl:ENST00000373873|ensembl:ENSP00000362980|ensembl:ENSP00000385636|ensembl:ENST00000603926|ensembl:ENSP00000474519|dip:DIP-38340N|ensembl:ENSG00000124006(gene)|ensembl:ENST00000404537(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010842"(retina layer formation)|go:"GO:0014704"(intercalated disc)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:1990393"(3M complex)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O75147|rcsb pdb:2CPC|rcsb pdb:2E6P|rcsb pdb:2E6Q|rcsb pdb:2LU7|rcsb pdb:2LVC|rcsb pdb:2WP3|rcsb pdb:2WWK|rcsb pdb:2WWM|rcsb pdb:3KNB|rcsb pdb:5FM5|reactome:R-HSA-8951664 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:HFxqB+AxsXH/zWXgCj/ODfSmqQQ9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q9H0W5 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-5236005|uniprotkb:Q8TB26|ensembl:ENSP00000303158 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:ccdc8_human(display_long)|uniprotkb:CCDC8(gene name)|psi-mi:CCDC8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_114429.2|dip:DIP-60183N|ensembl:ENSG00000169515(gene)|ensembl:ENST00000307522(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:1990393"(3M complex)|interpro:IPR026523|mint:Q9H0W5|rcsb pdb:4LG6|reactome:R-HSA-8951664 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:WZYxMX583xXAxpOLGC8gyR7+/fU9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:P61758 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:P40227 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-356687|uniprotkb:Q3KP28|uniprotkb:Q75LP4|uniprotkb:Q96S46|ensembl:ENSP00000275603|intact:EBI-5912031|uniprotkb:A6NCD2 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:tcpz_human(display_long)|uniprotkb:CCT6A(gene name)|psi-mi:CCT6A(display_short)|uniprotkb:CCT6(gene name synonym)|uniprotkb:CCTZ(gene name synonym)|uniprotkb:CCT-zeta-1(gene name synonym)|uniprotkb:Tcp20(gene name synonym)|uniprotkb:HTR3(gene name synonym)|uniprotkb:Acute morphine dependence-related protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_001753.1|ensembl:ENSG00000146731(gene)|ensembl:ENST00000275603(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P40227|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|refseq:NP_001009186.1|dip:DIP-33558N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:kX6/rTGZbGuVLNgBW6IxdNlU46U9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:P49368 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-356673|uniprotkb:Q5SZY1|uniprotkb:Q9BR64|uniprotkb:A6NE14|ensembl:ENSP00000295688 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:tcpg_human(display_long)|uniprotkb:CCT3(gene name)|psi-mi:CCT3(display_short)|uniprotkb:CCTG(gene name synonym)|uniprotkb:TRIC5(gene name synonym)|uniprotkb:CCT-gamma(gene name synonym)|uniprotkb:hTRiC5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_001008800.1|refseq:NP_005989.3|ensembl:ENSG00000163468(gene)|ensembl:ENST00000295688(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0046931"(pore complex assembly)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012719(T-complex protein 1, gamma subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P49368|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|dip:DIP-32970N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:2Vh45aNIeqiAp1NHbIabV2kEYUU9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:P78371 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-357407|uniprotkb:Q14D36|uniprotkb:Q6IAT3|uniprotkb:A8K402|uniprotkb:B5BTY7|uniprotkb:B7Z243|uniprotkb:B7Z7K4|uniprotkb:B7ZAT2|ensembl:ENSP00000299300 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:tcpb_human(display_long)|uniprotkb:CCT2(gene name)|psi-mi:CCT2(display_short)|uniprotkb:99D8.1(gene name synonym)|uniprotkb:CCTB(gene name synonym)|uniprotkb:CCT-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_006422.1|refseq:NP_001185771.1|dip:DIP-38123N|ensembl:ENSG00000166226(gene)|ensembl:ENST00000299300(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051086"(chaperone mediated protein folding independent of cofactor)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012716(T-complex protein 1, beta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P78371|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-5620922|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-6798695 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:YHuvdAzWVCxx1WNk1bF/4tlOxf89606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q99832 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q99471 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q92526 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-2479962|ensembl:ENSP00000327191|uniprotkb:Q8TC34|uniprotkb:B4DYB0|uniprotkb:B4DX20 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:tcpw_human(display_long)|uniprotkb:CCT6B(gene name)|psi-mi:CCT6B(display_short)|uniprotkb:CCT-zeta-2(gene name synonym)|uniprotkb:TCP-1-zeta-like(gene name synonym)|uniprotkb:CCT-zeta-like(gene name synonym)|uniprotkb:Testis-specific Tcp20(gene name synonym)|uniprotkb:Testis-specific protein TSA303(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012722(T-complex protein 1, zeta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|ensembl:ENSG00000132141(gene)|ensembl:ENST00000314144(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0006457"(protein folding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1901998"(toxin transport)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|refseq:NP_001180458.1|refseq:NP_001180459.1|refseq:NP_006575.2|dip:DIP-53269N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:VsftnWywz8pwjvqMpE33d9z3bY09606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q13617 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q13616 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:P63208-1 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-307497|uniprotkb:P34991-1|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:p63208-1(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) intact:EBI-307486(skp1_human)|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000517625(transcript)|ensembl:ENST00000522855(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:Q8N3Y1-2 uniprotkb:Q14999 intact:EBI-15927105|ensembl:ENSP00000389144 intact:EBI-308606|uniprotkb:Q5T654|ensembl:ENSP00000265348|uniprotkb:B4DYZ0|uniprotkb:F5H0L1 psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:cul7_human(display_long)|uniprotkb:CUL7(gene name)|psi-mi:CUL7(display_short)|uniprotkb:KIAA0076(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15927108|imex:IM-21064-2|dip:DIP-190700E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) ensembl:ENSG00000044090(gene)|ensembl:ENST00000265348(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|mint:Q14999|rcsb pdb:2JNG|reactome:R-HSA-381038|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_001161842.1|refseq:NP_055595.2|dip:DIP-31618N|dip:DIP-60187N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2019/04/15 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rogid:8sODZSppCsuEgRmhSHp3UjwOf2M9606 rigid:slfokV9PWzTr6UsJ9PdmvfJWhZs false ha tag:?-? - - - psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry) uniprotkb:P62989 uniprotkb:B1WBR1 intact:EBI-7038538|dip:DIP-36896N|uniprotkb:Q91887|uniprotkb:Q63446|uniprotkb:Q91888|uniprotkb:P02248|uniprotkb:P02250|mint:MINT-1347800|uniprotkb:P02249|uniprotkb:Q29120 intact:EBI-15927064|ensembl:ENSRNOP00000024408 psi-mi:ubiq_rat(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short) psi-mi:b1wbr1_rat(display_long)|uniprotkb:Gorasp1(gene name)|psi-mi:Gorasp1(display_short)|uniprotkb:rCG_25352(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927082|imex:IM-21064-1|dip:DIP-190704E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000019974|interpro:IPR019955|ensembl:ENSRNOG00000042271|refseq:NP_620250.1|ipi:IPI00656453|ensembl:ENSRNOG00000034246|go:"GO:0022627"(cytosolic small ribosomal subunit)|refseq:XP_002726633.1|refseq:NP_112375.1|go:"GO:0005634"(nucleus)|ensembl:ENSRNOG00000004426|interpro:IPR019956|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|refseq:NP_113875.1|ensembl:ENSRNOG00000028756|refseq:XP_002729582.1|rgd:620240 ensembl:ENSRNOG00000018047(gene)|ensembl:ENSRNOT00000024408(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|interpro:IPR007583(GRASP55/65)|interpro:IPR024958|interpro:IPR036034|refseq:NP_062258.2|rgd:621122|dip:DIP-60184N psi-mi:"MI:0465"(dip) function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/07 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10116 rogid:zz6nYmhfVLbi6oOtRMFbI4wK0Bg10116 rigid:nJ9twSymTMgys8Jh6izUwdaD9x8 false ha tag:0-0 green fluorescent protein tag:c-c|sufficient binding region:5-74 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14999 uniprotkb:O75147-2 intact:EBI-308606|uniprotkb:Q5T654|ensembl:ENSP00000265348|uniprotkb:B4DYZ0|uniprotkb:F5H0L1 intact:EBI-15927144|ensembl:ENSP00000362980 psi-mi:cul7_human(display_long)|uniprotkb:CUL7(gene name)|psi-mi:CUL7(display_short)|uniprotkb:KIAA0076(gene name synonym) psi-mi:o75147-2(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927148|imex:IM-21064-3|dip:DIP-190706E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000044090(gene)|ensembl:ENST00000265348(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|mint:Q14999|rcsb pdb:2JNG|reactome:R-HSA-381038|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_001161842.1|refseq:NP_055595.2|dip:DIP-31618N|dip:DIP-60187N intact:EBI-1223896(isoform-parent)|ensembl:ENSG00000124006(gene)|ensembl:ENST00000373873(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:8sODZSppCsuEgRmhSHp3UjwOf2M9606 rogid:E+tD+quUJbjiputYyQirR5LxK2o9606 rigid:TRUQibt7V76kWJkndJ5yH9LeMNA false ha tag:c-c v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B1WBR1 uniprotkb:Q8N3Y1-2 intact:EBI-15927064|ensembl:ENSRNOP00000024408 intact:EBI-15927105|ensembl:ENSP00000389144 psi-mi:b1wbr1_rat(display_long)|uniprotkb:Gorasp1(gene name)|psi-mi:Gorasp1(display_short)|uniprotkb:rCG_25352(orf name) psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927171|imex:IM-21064-4|dip:DIP-190701E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000018047(gene)|ensembl:ENSRNOT00000024408(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|interpro:IPR007583(GRASP55/65)|interpro:IPR024958|interpro:IPR036034|refseq:NP_062258.2|rgd:621122|dip:DIP-60184N intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:zz6nYmhfVLbi6oOtRMFbI4wK0Bg10116 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rigid:/5y3zwtMfjNyVS219EDRlhfu5NM false sufficient binding region:5-74|green fluorescent protein tag:c-c flag tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O35254 uniprotkb:A0A0G2JUJ2 intact:EBI-4422879 intact:EBI-15927196|ensembl:ENSRNOP00000069117 psi-mi:gors1_rat(display_long)|uniprotkb:Gorasp1(gene name)|psi-mi:Gorasp1(display_short)|uniprotkb:Grasp65(gene name synonym)|uniprotkb:Golgi peripheral membrane protein p65(gene name synonym)|uniprotkb:Golgi reassembly-stacking protein of 65 kDa(gene name synonym) psi-mi:a0a0g2juj2_rat(display_long)|uniprotkb:Fbxw8(gene name)|psi-mi:Fbxw8(display_short)|uniprotkb:Fbxw8_predicted(gene name synonym)|uniprotkb:rCG_21928(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927211|imex:IM-21064-5|dip:DIP-190702E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-RNO-162658|reactome:R-RNO-204005|reactome:R-RNO-6807878|rgd:621122|dip:DIP-60188N|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|interpro:IPR007583(GRASP55/65)|interpro:IPR024958|interpro:IPR036034|rcsb pdb:4KFV ensembl:ENSRNOG00000001126(gene)|ensembl:ENSRNOT00000080853(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|refseq:NP_001100615.1|rgd:1306032 psi-mi:"MI:0465"(dip) - crc64:2714058B6C86E3EF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/07 2017/08/10 rogid:p5nd8rTnCSIeDZ3ecrOKobwqS/810116 rogid:kT+S4xsVFfF2fWj0SlK7yCxbsao10116 rigid:/25wShmyEKlInfX6cS5bs72eErk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14999 uniprotkb:O75147-2 intact:EBI-308606|uniprotkb:Q5T654|ensembl:ENSP00000265348|uniprotkb:B4DYZ0|uniprotkb:F5H0L1 intact:EBI-15927144|ensembl:ENSP00000362980 psi-mi:cul7_human(display_long)|uniprotkb:CUL7(gene name)|psi-mi:CUL7(display_short)|uniprotkb:KIAA0076(gene name synonym) psi-mi:o75147-2(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym) psi-mi:"MI:0096"(pull down) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15927228|imex:IM-21064-6|dip:DIP-190706E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000044090(gene)|ensembl:ENST00000265348(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|mint:Q14999|rcsb pdb:2JNG|reactome:R-HSA-381038|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_001161842.1|refseq:NP_055595.2|dip:DIP-31618N|dip:DIP-60187N intact:EBI-1223896(isoform-parent)|ensembl:ENSG00000124006(gene)|ensembl:ENST00000373873(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/07 2017/08/10 rogid:8sODZSppCsuEgRmhSHp3UjwOf2M9606 rogid:E+tD+quUJbjiputYyQirR5LxK2o9606 rigid:TRUQibt7V76kWJkndJ5yH9LeMNA false binding-associated region:?-?|glutathione s tranferase tag:n-n v5 tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:D3ZEF4 uniprotkb:A0A0G2JUJ2 intact:EBI-15927255 intact:EBI-15927196|ensembl:ENSRNOP00000069117 psi-mi:cul7_rat(display_long)|uniprotkb:Cul7(gene name)|psi-mi:Cul7(display_short) psi-mi:a0a0g2juj2_rat(display_long)|uniprotkb:Fbxw8(gene name)|psi-mi:Fbxw8(display_short)|uniprotkb:Fbxw8_predicted(gene name synonym)|uniprotkb:rCG_21928(orf name) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927289|imex:IM-21064-7|dip:DIP-190705E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|reactome:R-RNO-8951664|reactome:R-RNO-983168|rgd:1587048|dip:DIP-60186N ensembl:ENSRNOG00000001126(gene)|ensembl:ENSRNOT00000080853(transcript)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|refseq:NP_001100615.1|rgd:1306032 psi-mi:"MI:0465"(dip) - crc64:2714058B6C86E3EF full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/07 2017/08/10 rogid:TIq12bhYvTxpGgGA8qer3hhxr6s10116 rogid:kT+S4xsVFfF2fWj0SlK7yCxbsao10116 rigid:RwcynYTFo7jCJy9TYZsEK6DCDfY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14999 uniprotkb:O75147-2 intact:EBI-308606|uniprotkb:Q5T654|ensembl:ENSP00000265348|uniprotkb:B4DYZ0|uniprotkb:F5H0L1 intact:EBI-15927144|ensembl:ENSP00000362980 psi-mi:cul7_human(display_long)|uniprotkb:CUL7(gene name)|psi-mi:CUL7(display_short)|uniprotkb:KIAA0076(gene name synonym) psi-mi:o75147-2(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927306|imex:IM-21064-8|dip:DIP-190706E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000044090(gene)|ensembl:ENST00000265348(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|mint:Q14999|rcsb pdb:2JNG|reactome:R-HSA-381038|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_001161842.1|refseq:NP_055595.2|dip:DIP-31618N|dip:DIP-60187N intact:EBI-1223896(isoform-parent)|ensembl:ENSG00000124006(gene)|ensembl:ENST00000373873(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:8sODZSppCsuEgRmhSHp3UjwOf2M9606 rogid:E+tD+quUJbjiputYyQirR5LxK2o9606 rigid:TRUQibt7V76kWJkndJ5yH9LeMNA false ha tag:c-c v5 tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WBR1 uniprotkb:Q8N3Y1-2 intact:EBI-15927064|ensembl:ENSRNOP00000024408 intact:EBI-15927105|ensembl:ENSP00000389144 psi-mi:b1wbr1_rat(display_long)|uniprotkb:Gorasp1(gene name)|psi-mi:Gorasp1(display_short)|uniprotkb:rCG_25352(orf name) psi-mi:q8n3y1-2(display_long)|uniprotkb:FBXW8(gene name)|psi-mi:FBXW8(display_short)|uniprotkb:F-box and WD-40 domain-containing protein 8(gene name synonym)|uniprotkb:F-box only protein 29(gene name synonym)|uniprotkb:FBW6(gene name synonym)|uniprotkb:FBW8(gene name synonym)|uniprotkb:FBX29(gene name synonym)|uniprotkb:FBXO29(gene name synonym)|uniprotkb:FBXW6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927356|imex:IM-21064-10|dip:DIP-190701E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000018047(gene)|ensembl:ENSRNOT00000024408(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0016020"(membrane)|interpro:IPR007583(GRASP55/65)|interpro:IPR024958|interpro:IPR036034|refseq:NP_062258.2|rgd:621122|dip:DIP-60184N intact:EBI-914770(isoform-parent)|ensembl:ENSG00000174989(gene)|ensembl:ENST00000455858(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:zz6nYmhfVLbi6oOtRMFbI4wK0Bg10116 rogid:KoJLsztY9wAw+ZA7jaKJc5Aaj0k9606 rigid:/5y3zwtMfjNyVS219EDRlhfu5NM false green fluorescent protein tag:c-c flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14999 uniprotkb:O75147-2 intact:EBI-308606|uniprotkb:Q5T654|ensembl:ENSP00000265348|uniprotkb:B4DYZ0|uniprotkb:F5H0L1 intact:EBI-15927144|ensembl:ENSP00000362980 psi-mi:cul7_human(display_long)|uniprotkb:CUL7(gene name)|psi-mi:CUL7(display_short)|uniprotkb:KIAA0076(gene name synonym) psi-mi:o75147-2(display_long)|uniprotkb:OBSL1(gene name)|psi-mi:OBSL1(display_short)|uniprotkb:KIAA0657(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927329|imex:IM-21064-9|dip:DIP-190706E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000044090(gene)|ensembl:ENST00000265348(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001890"(placenta development)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:1990393"(3M complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016158(Cullin homology)|interpro:IPR019559|interpro:IPR021097|interpro:IPR031223|interpro:IPR036317|interpro:IPR036388|mint:Q14999|rcsb pdb:2JNG|reactome:R-HSA-381038|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_001161842.1|refseq:NP_055595.2|dip:DIP-31618N|dip:DIP-60187N intact:EBI-1223896(isoform-parent)|ensembl:ENSG00000124006(gene)|ensembl:ENST00000373873(transcript) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/07 2017/08/10 rogid:8sODZSppCsuEgRmhSHp3UjwOf2M9606 rogid:E+tD+quUJbjiputYyQirR5LxK2o9606 rigid:TRUQibt7V76kWJkndJ5yH9LeMNA false ha tag:c-c|necessary binding region:1605..1605-c v5 tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P62989 uniprotkb:O35254 intact:EBI-7038538|dip:DIP-36896N|uniprotkb:Q91887|uniprotkb:Q63446|uniprotkb:Q91888|uniprotkb:P02248|uniprotkb:P02250|mint:MINT-1347800|uniprotkb:P02249|uniprotkb:Q29120 intact:EBI-4422879 psi-mi:ubiq_rat(display_long)|uniprotkb:Rps27a(gene name)|psi-mi:Rps27a(display_short)|uniprotkb:Uba80(gene name synonym)|uniprotkb:Ubcep1(gene name synonym)|uniprotkb:Uba52(gene name)|psi-mi:Uba52(display_short)|uniprotkb:Ubcep2(gene name synonym)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short) psi-mi:gors1_rat(display_long)|uniprotkb:Gorasp1(gene name)|psi-mi:Gorasp1(display_short)|uniprotkb:Grasp65(gene name synonym)|uniprotkb:Golgi peripheral membrane protein p65(gene name synonym)|uniprotkb:Golgi reassembly-stacking protein of 65 kDa(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Litterman et al. (2011) pubmed:21572988|doi:10.1371/journal.pbio.1001060|imex:IM-21064 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15927379|imex:IM-21064-11|dip:DIP-190703E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000019974|interpro:IPR019955|ensembl:ENSRNOG00000042271|refseq:NP_620250.1|ipi:IPI00656453|ensembl:ENSRNOG00000034246|go:"GO:0022627"(cytosolic small ribosomal subunit)|refseq:XP_002726633.1|refseq:NP_112375.1|go:"GO:0005634"(nucleus)|ensembl:ENSRNOG00000004426|interpro:IPR019956|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|refseq:NP_113875.1|ensembl:ENSRNOG00000028756|refseq:XP_002729582.1|rgd:620240 reactome:R-RNO-162658|reactome:R-RNO-204005|reactome:R-RNO-6807878|rgd:621122|dip:DIP-60188N|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0061951"(establishment of protein localization to plasma membrane)|interpro:IPR007583(GRASP55/65)|interpro:IPR024958|interpro:IPR036034|rcsb pdb:4KFV psi-mi:"MI:0465"(dip) function:Protein modifier which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Attachment to proteins as a Lys-48-linked polymer usually leads to their degradation by proteasome. Attachment to proteins as a monomer or as an alternatively linked polymer does not lead to proteasomal degradation and may be required for numerous functions, including maintenance of chromatin structure, regulation of gene expression, stress response, ribosome biogenesis and DNA repair|comment:mint - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2017/08/07 2017/08/15 rogid:dobaeYpohKyDSnm4fBbcy0ZbYwM10116 rogid:p5nd8rTnCSIeDZ3ecrOKobwqS/810116 rigid:9QaA4MAbRQNro6Aqj5oY3vntN20 false ha tag:0-0 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)