#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14964	uniprotkb:Q99816-1	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	intact:EBI-15891993|ensembl:ENSP00000251968	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:q99816-1(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Im et al. (2010)	pubmed:21070952|doi:10.1016/j.str.2010.08.010|imex:IM-15979	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15892021|imex:IM-15979-2|dip:DIP-70188E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	intact:EBI-346882(isoform-parent)|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	rigid:0IUrZG3Iyr9kBXedphQkwhkIRdg	false	binding-associated region:346-354	binding-associated region:2-145	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04591-PRO_0000038598	uniprotkb:Q99816-1	intact:EBI-10634977	intact:EBI-15891993|ensembl:ENSP00000251968	psi-mi:p04591-pro_0000038598(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym)	psi-mi:q99816-1(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Im et al. (2010)	pubmed:21070952|doi:10.1016/j.str.2010.08.010|imex:IM-15979	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15891999|imex:IM-15979-1|dip:DIP-186448E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6163428(chain-parent)	intact:EBI-346882(isoform-parent)|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)	psi-mi:"MI:0465"(dip)	chain-seq-start:449|chain-seq-end:500|crc64:9117D426B88A73CB	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:maxbPg1zDMQXgRwCIidWTHov6wU11706	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	rigid:cD0r1nA4ZR1Ki2nMmROGo1xsUIo	false	binding-associated region:5-13	binding-associated region:2-145	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04591-PRO_0000038598	uniprotkb:Q99816-1	intact:EBI-10634977	intact:EBI-15891993|ensembl:ENSP00000251968	psi-mi:p04591-pro_0000038598(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym)	psi-mi:q99816-1(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Im et al. (2010)	pubmed:21070952|doi:10.1016/j.str.2010.08.010|imex:IM-15979	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15892073|imex:IM-15979-4|dip:DIP-186448E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6163428(chain-parent)	intact:EBI-346882(isoform-parent)|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)	psi-mi:"MI:0465"(dip)	chain-seq-start:449|chain-seq-end:500|crc64:9117D426B88A73CB	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:maxbPg1zDMQXgRwCIidWTHov6wU11706	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	rigid:cD0r1nA4ZR1Ki2nMmROGo1xsUIo	false	binding-associated region:5-13	binding-associated region:2-145|mutation disrupting interaction:63-63|mutation disrupting interaction:69-69|mutation disrupting interaction:95-95	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04591-PRO_0000038598	uniprotkb:Q99816-1	intact:EBI-10634977	intact:EBI-15891993|ensembl:ENSP00000251968	psi-mi:p04591-pro_0000038598(display_long)|uniprotkb:gag(gene name)|psi-mi:gag(display_short)|uniprotkb:Pr55Gag(gene name synonym)	psi-mi:q99816-1(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Im et al. (2010)	pubmed:21070952|doi:10.1016/j.str.2010.08.010|imex:IM-15979	taxid:11706(hv1h2)|taxid:11706("Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15892042|imex:IM-15979-3|dip:DIP-186448E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-6163428(chain-parent)	intact:EBI-346882(isoform-parent)|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)	psi-mi:"MI:0465"(dip)	chain-seq-start:449|chain-seq-end:500|crc64:9117D426B88A73CB	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:maxbPg1zDMQXgRwCIidWTHov6wU11706	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	rigid:cD0r1nA4ZR1Ki2nMmROGo1xsUIo	false	binding-associated region:5-13|mutation decreasing interaction strength:7-7|mutation disrupting interaction strength:8-8|mutation disrupting interaction strength:9-9|mutation disrupting interaction:10-10|mutation disrupting interaction strength:9-9	binding-associated region:2-145	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14964	uniprotkb:Q99816-1	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	intact:EBI-15891993|ensembl:ENSP00000251968	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:q99816-1(display_long)|uniprotkb:TSG101(gene name)|psi-mi:TSG101(display_short)|uniprotkb:ESCRT-I complex subunit TSG101(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Im et al. (2010)	pubmed:21070952|doi:10.1016/j.str.2010.08.010|imex:IM-15979	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15892103|imex:IM-15979-5|dip:DIP-70188E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	intact:EBI-346882(isoform-parent)|ensembl:ENSG00000074319(gene)|ensembl:ENST00000251968(transcript)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:hoi+Pw0Rr3wL/1ePQINUq3BmSFI9606	rigid:0IUrZG3Iyr9kBXedphQkwhkIRdg	false	binding-associated region:346-354	binding-associated region:2-145	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)