#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-15877929	uniprotkb:Q8IWV8	dip:DIP-59066N	intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990	psi-mi:rifs(display_short)|psi-mi:EBI-15877929(display_long)	psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Matta-Camacho et al. (2010)	pubmed:20835242|doi:10.1038/nsmb.1894|imex:IM-16071	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877932|imex:IM-16071-1|dip:DIP-186937E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:V2Ak89/MHuWq7bywMXsqmZ0nQgk-2	rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606	rigid:vFXkA+OxVnUbooYhO8Lu4tuHwwY	false	binding-associated region:1-4	binding-associated region:98-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IWV7	intact:EBI-15877929	intact:EBI-711736|uniprotkb:O60708|uniprotkb:O75492|uniprotkb:Q14D45|uniprotkb:Q68DN9|uniprotkb:Q8IWY6|uniprotkb:Q96JY4|ensembl:ENSP00000290650	dip:DIP-59066N	psi-mi:ubr1_human(display_long)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-I(gene name synonym)|uniprotkb:UBR1(gene name)|psi-mi:UBR1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase UBR1(gene name synonym)	psi-mi:rifs(display_short)|psi-mi:EBI-15877929(display_long)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Matta-Camacho et al. (2010)	pubmed:20835242|doi:10.1038/nsmb.1894|imex:IM-16071	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877972|imex:IM-16071-3|dip:DIP-186938E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_777576.1|dip:DIP-47033N|ensembl:ENSG00000159459(gene)|ensembl:ENST00000290650(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV7|rcsb pdb:3NY1|rcsb pdb:5TDC|reactome:R-HSA-983168	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:BcTsfaVfIa+WpIb8EPaPca2UZN89606	rogid:V2Ak89/MHuWq7bywMXsqmZ0nQgk-2	rigid:d63SMeD0qAyOKQ4IZLb7E/MnUIA	false	binding-associated region:97-167	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15877929	uniprotkb:Q8IWV8	dip:DIP-59066N	intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990	psi-mi:rifs(display_short)|psi-mi:EBI-15877929(display_long)	psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Matta-Camacho et al. (2010)	pubmed:20835242|doi:10.1038/nsmb.1894|imex:IM-16071	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877991|imex:IM-16071-4|dip:DIP-186937E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:V2Ak89/MHuWq7bywMXsqmZ0nQgk-2	rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606	rigid:vFXkA+OxVnUbooYhO8Lu4tuHwwY	false	-	binding-associated region:98-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
intact:EBI-15877929	uniprotkb:Q8IWV8	dip:DIP-59066N	intact:EBI-1237260|uniprotkb:O15057|uniprotkb:Q4VXK2|uniprotkb:Q5TFH6|uniprotkb:Q6P2I2|uniprotkb:Q6ZUD0|ensembl:ENSP00000361990	psi-mi:rifs(display_short)|psi-mi:EBI-15877929(display_long)	psi-mi:ubr2_human(display_long)|uniprotkb:UBR2(gene name)|psi-mi:UBR2(display_short)|uniprotkb:C6orf133(gene name synonym)|uniprotkb:KIAA0349(gene name synonym)|uniprotkb:N-recognin-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-II(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UBR2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Matta-Camacho et al. (2010)	pubmed:20835242|doi:10.1038/nsmb.1894|imex:IM-16071	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15877953|imex:IM-16071-2|dip:DIP-186937E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0327"(peptide)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001171730.1|refseq:NP_056070.1|refseq:XP_005249022.1|dip:DIP-38165N|ensembl:ENSG00000024048(gene)|ensembl:ENST00000372899(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006342"|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007140"(male meiotic nuclear division)|go:"GO:0007141"(male meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010529"(negative regulation of transposition)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV8|rcsb pdb:3NY2|rcsb pdb:3NY3|rcsb pdb:5TDA|rcsb pdb:5TDB|rcsb pdb:5TDD|rcsb pdb:5UM3|reactome:R-HSA-983168	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:V2Ak89/MHuWq7bywMXsqmZ0nQgk-2	rogid:FhRNI+FmJXWFjMAY1EUCiwqZPGY9606	rigid:vFXkA+OxVnUbooYhO8Lu4tuHwwY	false	-	binding-associated region:98-167	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IWV7	intact:EBI-15877929	intact:EBI-711736|uniprotkb:O60708|uniprotkb:O75492|uniprotkb:Q14D45|uniprotkb:Q68DN9|uniprotkb:Q8IWY6|uniprotkb:Q96JY4|ensembl:ENSP00000290650	dip:DIP-59066N	psi-mi:ubr1_human(display_long)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-I(gene name synonym)|uniprotkb:UBR1(gene name)|psi-mi:UBR1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase UBR1(gene name synonym)	psi-mi:rifs(display_short)|psi-mi:EBI-15877929(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Matta-Camacho et al. (2010)	pubmed:20835242|doi:10.1038/nsmb.1894|imex:IM-16071	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15878010|imex:IM-16071-5|dip:DIP-186938E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_777576.1|dip:DIP-47033N|ensembl:ENSG00000159459(gene)|ensembl:ENST00000290650(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000502"(proteasome complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR042065|interpro:IPR044046|mint:Q8IWV7|rcsb pdb:3NY1|rcsb pdb:5TDC|reactome:R-HSA-983168	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:BcTsfaVfIa+WpIb8EPaPca2UZN89606	rogid:V2Ak89/MHuWq7bywMXsqmZ0nQgk-2	rigid:d63SMeD0qAyOKQ4IZLb7E/MnUIA	false	binding-associated region:97-167|mutation disrupting interaction:136-136|mutation disrupting interaction strength:118-118|mutation disrupting interaction:147-147|mutation disrupting interaction:150-150|mutation disrupting interaction strength:118-118	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)