#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:A2AGH6 uniprotkb:Q80YQ2 intact:EBI-5744969|uniprotkb:A2AGH7|uniprotkb:O88542|uniprotkb:Q571H3|uniprotkb:Q6PGB4|uniprotkb:Q6PGD8|ensembl:ENSMUSP00000085260 intact:EBI-5745001|uniprotkb:Q6ZPV7|uniprotkb:Q8CEC3|uniprotkb:Q8K587|uniprotkb:Q9CXY8 psi-mi:med12_mouse(display_long)|uniprotkb:Med12(gene name)|psi-mi:Med12(display_short)|uniprotkb:Kiaa0192(gene name synonym)|uniprotkb:Mopa(gene name synonym)|uniprotkb:Tnrc11(gene name synonym)|uniprotkb:Trap230(gene name synonym)|uniprotkb:Mediator complex subunit 12(gene name synonym)|uniprotkb:OPA-containing protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 230 kDa component(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 11 protein(gene name synonym) psi-mi:med23_mouse(display_long)|uniprotkb:Med23(gene name)|psi-mi:Med23(display_short)|uniprotkb:Crsp3(gene name synonym)|uniprotkb:Kiaa1216(gene name synonym)|uniprotkb:Sur2(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 3(gene name synonym)|uniprotkb:Mediator complex subunit 23(gene name synonym)|uniprotkb:Protein sur-2 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15871097|imex:IM-16283-1|dip:DIP-187416E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_067496.2|go:"GO:0048568"(embryonic organ development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR019035|interpro:IPR021989|interpro:IPR021990|mint:A2AGH6|reactome:R-MMU-212436|ensembl:ENSMUSG00000079487(gene)|ensembl:ENSMUST00000087948(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|dip:DIP-59233N refseq:NP_001159888.1|refseq:NP_081623.3|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:2000409"(positive regulation of T cell extravasation)|interpro:IPR021629|rcsb pdb:6W1S|dip:DIP-59234N|reactome:R-MMU-212436 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:9l10cOqNn+PIwL7gQq/WsgiZnLE10090 rogid:unJwhtOAP16TniaelImM6E3JM8o10090 rigid:q9F5BKOtEntxd5QA1MJcd3IqIKI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R3L8 uniprotkb:Q924H2 intact:EBI-5745402|ensembl:ENSMUSP00000031640 intact:EBI-6260935|ensembl:ENSMUSP00000012259|uniprotkb:G3X8S4 psi-mi:cdk8_mouse(display_long)|uniprotkb:Cdk8(gene name)|psi-mi:Cdk8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym) psi-mi:med15_mouse(display_long)|uniprotkb:Mediator complex subunit 15(gene name synonym)|uniprotkb:Pcqap(gene name synonym)|uniprotkb:Positive cofactor 2 glutamine/Q-rich-associated protein(gene name synonym)|uniprotkb:Med15(gene name)|psi-mi:Med15(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871114|imex:IM-16283-2|dip:DIP-187419E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_705827.2|refseq:XP_006504899.1|dip:DIP-59235N|ensembl:ENSMUSG00000029635(gene)|ensembl:ENSMUST00000031640(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-212436|reactome:R-MMU-2173796 ensembl:ENSMUSG00000012114(gene)|ensembl:ENSMUST00000012259(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|interpro:IPR019087|interpro:IPR036529|mint:Q924H2|rcsb pdb:6W1S|reactome:R-MMU-212436|dip:DIP-59237N|refseq:NP_291087.2 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:tHawaDeeX08GRFLqNZ5pZJxtCZE10090 rogid:mZasSGGG3iCf4B+EFvrHwfeRm0I10090 rigid:sxlry2H6jxhwA4ZBP0x52FZc70A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R3L8 uniprotkb:A2AGH6 intact:EBI-5745402|ensembl:ENSMUSP00000031640 intact:EBI-5744969|uniprotkb:A2AGH7|uniprotkb:O88542|uniprotkb:Q571H3|uniprotkb:Q6PGB4|uniprotkb:Q6PGD8|ensembl:ENSMUSP00000085260 psi-mi:cdk8_mouse(display_long)|uniprotkb:Cdk8(gene name)|psi-mi:Cdk8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym) psi-mi:med12_mouse(display_long)|uniprotkb:Med12(gene name)|psi-mi:Med12(display_short)|uniprotkb:Kiaa0192(gene name synonym)|uniprotkb:Mopa(gene name synonym)|uniprotkb:Tnrc11(gene name synonym)|uniprotkb:Trap230(gene name synonym)|uniprotkb:Mediator complex subunit 12(gene name synonym)|uniprotkb:OPA-containing protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 230 kDa component(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 11 protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871114|imex:IM-16283-2|dip:DIP-187419E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_705827.2|refseq:XP_006504899.1|dip:DIP-59235N|ensembl:ENSMUSG00000029635(gene)|ensembl:ENSMUST00000031640(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-212436|reactome:R-MMU-2173796 refseq:NP_067496.2|go:"GO:0048568"(embryonic organ development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR019035|interpro:IPR021989|interpro:IPR021990|mint:A2AGH6|reactome:R-MMU-212436|ensembl:ENSMUSG00000079487(gene)|ensembl:ENSMUST00000087948(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|dip:DIP-59233N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:tHawaDeeX08GRFLqNZ5pZJxtCZE10090 rogid:9l10cOqNn+PIwL7gQq/WsgiZnLE10090 rigid:sxlry2H6jxhwA4ZBP0x52FZc70A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R3L8 uniprotkb:Q6KCD5 intact:EBI-5745402|ensembl:ENSMUSP00000031640 intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6 psi-mi:cdk8_mouse(display_long)|uniprotkb:Cdk8(gene name)|psi-mi:Cdk8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym) psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871114|imex:IM-16283-2|dip:DIP-187419E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_705827.2|refseq:XP_006504899.1|dip:DIP-59235N|ensembl:ENSMUSG00000029635(gene)|ensembl:ENSMUST00000031640(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-212436|reactome:R-MMU-2173796 ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:tHawaDeeX08GRFLqNZ5pZJxtCZE10090 rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090 rigid:sxlry2H6jxhwA4ZBP0x52FZc70A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8R3L8 uniprotkb:Q9CW03 intact:EBI-5745402|ensembl:ENSMUSP00000031640 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 psi-mi:cdk8_mouse(display_long)|uniprotkb:Cdk8(gene name)|psi-mi:Cdk8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym) psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871114|imex:IM-16283-2|dip:DIP-187419E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_705827.2|refseq:XP_006504899.1|dip:DIP-59235N|ensembl:ENSMUSG00000029635(gene)|ensembl:ENSMUST00000031640(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-212436|reactome:R-MMU-2173796 ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:tHawaDeeX08GRFLqNZ5pZJxtCZE10090 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 rigid:sxlry2H6jxhwA4ZBP0x52FZc70A false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q6KCD5 uniprotkb:Q80YQ2 intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6 intact:EBI-5745001|uniprotkb:Q6ZPV7|uniprotkb:Q8CEC3|uniprotkb:Q8K587|uniprotkb:Q9CXY8 psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym) psi-mi:med23_mouse(display_long)|uniprotkb:Med23(gene name)|psi-mi:Med23(display_short)|uniprotkb:Crsp3(gene name synonym)|uniprotkb:Kiaa1216(gene name synonym)|uniprotkb:Sur2(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 3(gene name synonym)|uniprotkb:Mediator complex subunit 23(gene name synonym)|uniprotkb:Protein sur-2 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871134|imex:IM-16283-3|dip:DIP-187414E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N refseq:NP_001159888.1|refseq:NP_081623.3|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:2000409"(positive regulation of T cell extravasation)|interpro:IPR021629|rcsb pdb:6W1S|dip:DIP-59234N|reactome:R-MMU-212436 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090 rogid:unJwhtOAP16TniaelImM6E3JM8o10090 rigid:osVMhSp7dShK7XKCKkVCjosuO7k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6KCD5 uniprotkb:Q9CW03 intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym) psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871134|imex:IM-16283-3|dip:DIP-187414E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 rigid:osVMhSp7dShK7XKCKkVCjosuO7k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6KCD5 uniprotkb:Q9CU62 intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6 intact:EBI-2550016|uniprotkb:A2AFQ5|ensembl:ENSMUSP00000044645|uniprotkb:Q3V480|uniprotkb:Q9CUX9|uniprotkb:Q9D959|uniprotkb:Q9WTU1 psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym) psi-mi:smc1a_mouse(display_long)|uniprotkb:Smc1a(gene name)|psi-mi:Smc1a(display_short)|uniprotkb:Smc1(gene name synonym)|uniprotkb:Smc1l1(gene name synonym)|uniprotkb:Smcb(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)|uniprotkb:Chromosome segregation protein SmcB(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871134|imex:IM-16283-3|dip:DIP-187414E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N ensembl:ENSMUSG00000041133(gene)|ensembl:ENSMUST00000045312(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|go:"GO:0008278"(cohesin complex)|interpro:IPR036277|mint:Q9CU62|rcsb pdb:2WD5|reactome:R-MMU-2467813|interpro:IPR029683|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_062684.2|dip:DIP-57021N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090 rogid:3TtjC4Y8krgvnUafgy2DG2XTnH810090 rigid:osVMhSp7dShK7XKCKkVCjosuO7k false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CU62 uniprotkb:Q80YQ2 intact:EBI-2550016|uniprotkb:A2AFQ5|ensembl:ENSMUSP00000044645|uniprotkb:Q3V480|uniprotkb:Q9CUX9|uniprotkb:Q9D959|uniprotkb:Q9WTU1 intact:EBI-5745001|uniprotkb:Q6ZPV7|uniprotkb:Q8CEC3|uniprotkb:Q8K587|uniprotkb:Q9CXY8 psi-mi:smc1a_mouse(display_long)|uniprotkb:Smc1a(gene name)|psi-mi:Smc1a(display_short)|uniprotkb:Smc1(gene name synonym)|uniprotkb:Smc1l1(gene name synonym)|uniprotkb:Smcb(gene name synonym)|uniprotkb:Sb1.8(gene name synonym)|uniprotkb:Chromosome segregation protein SmcB(gene name synonym) psi-mi:med23_mouse(display_long)|uniprotkb:Med23(gene name)|psi-mi:Med23(display_short)|uniprotkb:Crsp3(gene name synonym)|uniprotkb:Kiaa1216(gene name synonym)|uniprotkb:Sur2(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 3(gene name synonym)|uniprotkb:Mediator complex subunit 23(gene name synonym)|uniprotkb:Protein sur-2 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15871153|imex:IM-16283-4|dip:DIP-187417E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000041133(gene)|ensembl:ENSMUST00000045312(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|go:"GO:0008278"(cohesin complex)|interpro:IPR036277|mint:Q9CU62|rcsb pdb:2WD5|reactome:R-MMU-2467813|interpro:IPR029683|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_062684.2|dip:DIP-57021N refseq:NP_001159888.1|refseq:NP_081623.3|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:2000409"(positive regulation of T cell extravasation)|interpro:IPR021629|rcsb pdb:6W1S|dip:DIP-59234N|reactome:R-MMU-212436 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:3TtjC4Y8krgvnUafgy2DG2XTnH810090 rogid:unJwhtOAP16TniaelImM6E3JM8o10090 rigid:oR7bW3vfO5Qw6xSmkMMBcPNsroA false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q80YQ2 uniprotkb:Q925J9 intact:EBI-5745001|uniprotkb:Q6ZPV7|uniprotkb:Q8CEC3|uniprotkb:Q8K587|uniprotkb:Q9CXY8 intact:EBI-5745083|ensembl:ENSMUSP00000103169|uniprotkb:A2A526|uniprotkb:A2A528|uniprotkb:O88323|uniprotkb:Q3UHV0|uniprotkb:Q6AXD5|uniprotkb:Q8BW37|uniprotkb:Q8BX19|uniprotkb:Q8VDQ7|uniprotkb:Q925K0 psi-mi:med23_mouse(display_long)|uniprotkb:Med23(gene name)|psi-mi:Med23(display_short)|uniprotkb:Crsp3(gene name synonym)|uniprotkb:Kiaa1216(gene name synonym)|uniprotkb:Sur2(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 3(gene name synonym)|uniprotkb:Mediator complex subunit 23(gene name synonym)|uniprotkb:Protein sur-2 homolog(gene name synonym) psi-mi:med1_mouse(display_long)|uniprotkb:Med1(gene name)|psi-mi:Med1(display_short)|uniprotkb:Crsp210(gene name synonym)|uniprotkb:Drip205(gene name synonym)|uniprotkb:Pbp(gene name synonym)|uniprotkb:Pparbp(gene name synonym)|uniprotkb:Trap220(gene name synonym)|uniprotkb:Trip2(gene name synonym)|uniprotkb:Mediator complex subunit 1(gene name synonym)|uniprotkb:Peroxisome proliferator-activated receptor-binding protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 220 kDa component(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15871170|imex:IM-16283-5|dip:DIP-187415E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001159888.1|refseq:NP_081623.3|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:2000409"(positive regulation of T cell extravasation)|interpro:IPR021629|rcsb pdb:6W1S|dip:DIP-59234N|reactome:R-MMU-212436 ensembl:ENSMUSG00000018160(gene)|ensembl:ENSMUST00000107545(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000785"(chromatin)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0002154"(thyroid hormone mediated signaling pathway)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003406"(retinal pigment epithelium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006702"(androgen biosynthetic process)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|refseq:NP_001073587.1|refseq:NP_038662.2|refseq:NP_598788.2|dip:DIP-59232N|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048821"(erythrocyte development)|go:"GO:0048822"(enucleate erythrocyte development)|go:"GO:0050693"(LBD domain binding)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060335"(positive regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060744"(mammary gland branching involved in thelarche)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070318"(positive regulation of G0 to G1 transition)|go:"GO:0070562"(regulation of vitamin D receptor signaling pathway)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR019680|mint:Q925J9|rcsb pdb:1XDK|reactome:R-MMU-212436|reactome:R-MMU-383280|reactome:R-MMU-400206|reactome:R-MMU-9018519|reactome:R-MMU-9707564 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:unJwhtOAP16TniaelImM6E3JM8o10090 rogid:U/w8SAVhDt9FGnx+YeK9FyNTjHo10090 rigid:QHuXSBkW1Y8uvpYRxLJQpHGSqe8 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9CW03 uniprotkb:Q80YQ2 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 intact:EBI-5745001|uniprotkb:Q6ZPV7|uniprotkb:Q8CEC3|uniprotkb:Q8K587|uniprotkb:Q9CXY8 psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:med23_mouse(display_long)|uniprotkb:Med23(gene name)|psi-mi:Med23(display_short)|uniprotkb:Crsp3(gene name synonym)|uniprotkb:Kiaa1216(gene name synonym)|uniprotkb:Sur2(gene name synonym)|uniprotkb:Cofactor required for Sp1 transcriptional activation subunit 3(gene name synonym)|uniprotkb:Mediator complex subunit 23(gene name synonym)|uniprotkb:Protein sur-2 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15871187|imex:IM-16283-6|dip:DIP-187418E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N refseq:NP_001159888.1|refseq:NP_081623.3|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:2000409"(positive regulation of T cell extravasation)|interpro:IPR021629|rcsb pdb:6W1S|dip:DIP-59234N|reactome:R-MMU-212436 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse)|taxid:10090(Mus musculus) - 2017/08/06 2017/08/10 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 rogid:unJwhtOAP16TniaelImM6E3JM8o10090 rigid:xjM4QujzV4xvJ6zHq8gd99Ji1GU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q8R3L8 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-5745402|ensembl:ENSMUSP00000031640 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:cdk8_mouse(display_long)|uniprotkb:Cdk8(gene name)|psi-mi:Cdk8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871204|dip:DIP-187420E|imex:IM-16283-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) refseq:NP_705827.2|refseq:XP_006504899.1|dip:DIP-59235N|ensembl:ENSMUSG00000029635(gene)|ensembl:ENSMUST00000031640(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-212436|reactome:R-MMU-2173796 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:tHawaDeeX08GRFLqNZ5pZJxtCZE10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q924H2 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-6260935|ensembl:ENSMUSP00000012259|uniprotkb:G3X8S4 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:med15_mouse(display_long)|uniprotkb:Mediator complex subunit 15(gene name synonym)|uniprotkb:Pcqap(gene name synonym)|uniprotkb:Positive cofactor 2 glutamine/Q-rich-associated protein(gene name synonym)|uniprotkb:Med15(gene name)|psi-mi:Med15(display_short) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871204|dip:DIP-187420E|imex:IM-16283-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) ensembl:ENSMUSG00000012114(gene)|ensembl:ENSMUST00000012259(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|interpro:IPR019087|interpro:IPR036529|mint:Q924H2|rcsb pdb:6W1S|reactome:R-MMU-212436|dip:DIP-59237N|refseq:NP_291087.2 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:mZasSGGG3iCf4B+EFvrHwfeRm0I10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:A2AGH6 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-5744969|uniprotkb:A2AGH7|uniprotkb:O88542|uniprotkb:Q571H3|uniprotkb:Q6PGB4|uniprotkb:Q6PGD8|ensembl:ENSMUSP00000085260 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:med12_mouse(display_long)|uniprotkb:Med12(gene name)|psi-mi:Med12(display_short)|uniprotkb:Kiaa0192(gene name synonym)|uniprotkb:Mopa(gene name synonym)|uniprotkb:Tnrc11(gene name synonym)|uniprotkb:Trap230(gene name synonym)|uniprotkb:Mediator complex subunit 12(gene name synonym)|uniprotkb:OPA-containing protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 230 kDa component(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 11 protein(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871204|dip:DIP-187420E|imex:IM-16283-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) refseq:NP_067496.2|go:"GO:0048568"(embryonic organ development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR019035|interpro:IPR021989|interpro:IPR021990|mint:A2AGH6|reactome:R-MMU-212436|ensembl:ENSMUSG00000079487(gene)|ensembl:ENSMUST00000087948(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|dip:DIP-59233N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:9l10cOqNn+PIwL7gQq/WsgiZnLE10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q6KCD5 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871204|dip:DIP-187420E|imex:IM-16283-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q9CW03 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871204|dip:DIP-187420E|imex:IM-16283-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q8R3L8 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-5745402|ensembl:ENSMUSP00000031640 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:cdk8_mouse(display_long)|uniprotkb:Cdk8(gene name)|psi-mi:Cdk8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871229|dip:DIP-189536E|imex:IM-16283-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) refseq:NP_705827.2|refseq:XP_006504899.1|dip:DIP-59235N|ensembl:ENSMUSG00000029635(gene)|ensembl:ENSMUST00000031640(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-212436|reactome:R-MMU-2173796 psi-mi:"MI:0465"(dip) - - dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-11-05|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:tHawaDeeX08GRFLqNZ5pZJxtCZE10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q924H2 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-6260935|ensembl:ENSMUSP00000012259|uniprotkb:G3X8S4 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:med15_mouse(display_long)|uniprotkb:Mediator complex subunit 15(gene name synonym)|uniprotkb:Pcqap(gene name synonym)|uniprotkb:Positive cofactor 2 glutamine/Q-rich-associated protein(gene name synonym)|uniprotkb:Med15(gene name)|psi-mi:Med15(display_short) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871229|dip:DIP-189536E|imex:IM-16283-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) ensembl:ENSMUSG00000012114(gene)|ensembl:ENSMUST00000012259(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|interpro:IPR019087|interpro:IPR036529|mint:Q924H2|rcsb pdb:6W1S|reactome:R-MMU-212436|dip:DIP-59237N|refseq:NP_291087.2 psi-mi:"MI:0465"(dip) - - dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-11-05|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:mZasSGGG3iCf4B+EFvrHwfeRm0I10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:A2AGH6 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-5744969|uniprotkb:A2AGH7|uniprotkb:O88542|uniprotkb:Q571H3|uniprotkb:Q6PGB4|uniprotkb:Q6PGD8|ensembl:ENSMUSP00000085260 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:med12_mouse(display_long)|uniprotkb:Med12(gene name)|psi-mi:Med12(display_short)|uniprotkb:Kiaa0192(gene name synonym)|uniprotkb:Mopa(gene name synonym)|uniprotkb:Tnrc11(gene name synonym)|uniprotkb:Trap230(gene name synonym)|uniprotkb:Mediator complex subunit 12(gene name synonym)|uniprotkb:OPA-containing protein(gene name synonym)|uniprotkb:Thyroid hormone receptor-associated protein complex 230 kDa component(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 11 protein(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871229|dip:DIP-189536E|imex:IM-16283-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) refseq:NP_067496.2|go:"GO:0048568"(embryonic organ development)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090245"(axis elongation involved in somitogenesis)|go:"GO:1990403"(embryonic brain development)|interpro:IPR019035|interpro:IPR021989|interpro:IPR021990|mint:A2AGH6|reactome:R-MMU-212436|ensembl:ENSMUSG00000079487(gene)|ensembl:ENSMUST00000087948(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001756"(somitogenesis)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016592"(mediator complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021915"(neural tube development)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046966"(thyroid hormone receptor binding)|dip:DIP-59233N psi-mi:"MI:0465"(dip) - - dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-11-05|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:9l10cOqNn+PIwL7gQq/WsgiZnLE10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q6KCD5 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-2551962|ensembl:ENSMUSP00000059385|uniprotkb:Q8CES9|uniprotkb:Q8BKV4|uniprotkb:Q7TNS4|uniprotkb:Q6KC78|uniprotkb:Q9CUC6 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:nipbl_mouse(display_long)|uniprotkb:Nipbl(gene name)|psi-mi:Nipbl(display_short)|uniprotkb:Delangin homolog(gene name synonym)|uniprotkb:SCC2 homolog(gene name synonym)|uniprotkb:Scc2(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871229|dip:DIP-189536E|imex:IM-16283-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) ensembl:ENSMUSG00000022141(gene)|ensembl:ENSMUST00000052965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032039"(integrator complex)|go:"GO:0032116"(SMC loading complex)|go:"GO:0034087"(establishment of mitotic sister chromatid cohesion)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0034088"(maintenance of mitotic sister chromatid cohesion)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035261"(external genitalia morphogenesis)|go:"GO:0036033"(mediator complex binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042471"(ear morphogenesis)|go:"GO:0042634"(regulation of hair cycle)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048565"(digestive tract development)|go:"GO:0048589"(developmental growth)|go:"GO:0048592"(eye morphogenesis)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061010"(gall bladder development)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:0070087"(chromo shadow domain binding)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0071921"(cohesin loading)|go:"GO:0090694"(Scc2-Scc4 cohesin loading complex)|go:"GO:1905406"(positive regulation of mitotic cohesin loading)|go:"GO:1990414"(replication-born double-strand break repair via sister chromatid exchange)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR024986|interpro:IPR026003|interpro:IPR033031|mint:Q6KCD5|reactome:R-MMU-2470946|interpro:IPR016024(Armadillo-type fold)|refseq:NP_081983.2|refseq:NP_957684.1|refseq:XP_017172234.1|refseq:XP_006520057.1|refseq:XP_006520058.1|dip:DIP-56622N psi-mi:"MI:0465"(dip) - - dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-11-05|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:88SuibrHZTM4RLN0OfOJD1cMzCo10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P36956-1 uniprotkb:Q9CW03 intact:EBI-948328|ensembl:ENSP00000261646 intact:EBI-2550068|ensembl:ENSMUSP00000025930|uniprotkb:O35667|uniprotkb:Q9QUS3 psi-mi:p36956-1(display_long)|uniprotkb:SREBF1(gene name)|psi-mi:SREBF1(display_short)|uniprotkb:BHLHD1(gene name synonym)|uniprotkb:SREBP1(gene name synonym)|uniprotkb:Class D basic helix-loop-helix protein 1(gene name synonym)|uniprotkb:Sterol regulatory element-binding transcription factor 1(gene name synonym) psi-mi:smc3_mouse(display_long)|uniprotkb:Smc3(gene name)|psi-mi:Smc3(display_short)|uniprotkb:Bam(gene name synonym)|uniprotkb:Bmh(gene name synonym)|uniprotkb:Cspg6(gene name synonym)|uniprotkb:Mmip1(gene name synonym)|uniprotkb:Smc3l1(gene name synonym)|uniprotkb:Smcd(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome segregation protein SmcD(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:Mad member-interacting protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Kagey et al. (2010) pubmed:20720539|doi:10.1038/nature09380|imex:IM-16283 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15871229|dip:DIP-189536E|imex:IM-16283-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000072310(gene)|ensembl:ENST00000261646(transcript)|intact:EBI-948313(srbp1_human) ensembl:ENSMUSG00000024974(gene)|ensembl:ENSMUST00000025930(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9CW03|rcsb pdb:2WD5|reactome:R-MMU-2467813|reactome:R-MMU-2468052|reactome:R-MMU-2470946|reactome:R-MMU-2500257|reactome:R-MMU-3108214|refseq:NP_031816.2|dip:DIP-57028N psi-mi:"MI:0465"(dip) - - dip-version:1|dip-updated-by:nodeMerge04|dip-date-update:2012-11-05|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/06 2018/02/26 rogid:DSEc6ZiI2ObB8g6FNEY9EGC+rps9606 rogid:9tJqVTJ2k3viYrJVtDfH2TekFIg10090 rigid:GrsRZMHYcaONadyf3TiSh6fyMWg false binding-associated region:1-50|glutathione s tranferase tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)