#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03122	uniprotkb:P41229	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-1246541|uniprotkb:B4E3I2|uniprotkb:F5H3T1|ensembl:ENSP00000364550|uniprotkb:Q5JUX3|uniprotkb:Q5JUX4|uniprotkb:Q5JUX5|uniprotkb:Q7Z5S5|uniprotkb:B0QZ44|intact:EBI-28983825	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kdm5c_human(display_long)|uniprotkb:KDM5C(gene name)|psi-mi:KDM5C(display_short)|uniprotkb:DXS1272E(gene name synonym)|uniprotkb:SMCX(gene name synonym)|uniprotkb:XE169(gene name synonym)|uniprotkb:Jumonji/ARID domain-containing protein 1C(gene name synonym)|uniprotkb:Protein SmcX(gene name synonym)|uniprotkb:Protein Xe169(gene name synonym)|uniprotkb:JARID1C(gene name synonym)|uniprotkb:Histone demethylase JARID1C(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(4) demethylase 5C"(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830615|imex:IM-17412-1|dip:DIP-188301E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N	refseq:NP_001140174.1|refseq:NP_004178.2|refseq:NP_001269551.1|ensembl:ENSG00000126012(gene)|ensembl:ENST00000375401(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0034647"(histone H3-tri/di/monomethyl-lysine-4 demethylase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0051213"(dioxygenase activity)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013637(PLU-1-like)|refseq:XP_011529128.1|ensembl:ENST00000375379|ensembl:ENSP00000364528|ensembl:ENST00000375383|ensembl:ENSP00000364532|ensembl:ENSP00000364550|ensembl:ENST00000404049|ensembl:ENSP00000385394|ensembl:ENST00000452825|ensembl:ENSP00000445176|refseq:XP_005262092.1|interpro:IPR019786|interpro:IPR019787|interpro:IPR036431|mint:P41229|rcsb pdb:2JRZ|rcsb pdb:5FWJ|reactome:R-HSA-3214842|dip:DIP-39663N	psi-mi:"MI:0465"(dip)	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:sBtK/VaMcyTMcinoqnOqwBdl7TM9606	rigid:vcdYoSwJsUnlWYNJvWSwij46a38	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03122	uniprotkb:Q96L91	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-399163|uniprotkb:O15411|uniprotkb:Q6P2F5|uniprotkb:Q8N8Q7|uniprotkb:Q8NE05|uniprotkb:Q96JK7|uniprotkb:Q9P230	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ep400_human(display_long)|uniprotkb:p400 kDa SWI2/SNF2-related protein(gene name synonym)|uniprotkb:Domino homolog(gene name synonym)|uniprotkb:CAG repeat protein 32(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 12 protein(gene name synonym)|uniprotkb:CAGH32(gene name synonym)|uniprotkb:KIAA1498(gene name synonym)|uniprotkb:KIAA1818(gene name synonym)|uniprotkb:TNRC12(gene name synonym)|uniprotkb:EP400(gene name)|psi-mi:EP400(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830654|imex:IM-17412-3|dip:DIP-188302E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N	refseq:NP_056224.3|ensembl:ENST00000389561|ensembl:ENSP00000374212|ensembl:ENSG00000183495|go:"GO:0000812"(Swr1 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0070615"|go:"GO:1990405"(protein antigen binding)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR027417|interpro:IPR031575|interpro:IPR038718|reactome:R-HSA-2559584|reactome:R-HSA-2559586|reactome:R-HSA-3214847|mint:Q96L91|dip:DIP-29915N	psi-mi:"MI:0465"(dip)	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:DrQFsyaSlUxjJBloZPFrjXooDpU9606	rigid:qIX4BaabCYNxItCSnap5a3mtTAQ	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03120	uniprotkb:O60885-1	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-9345088|ensembl:ENSP00000263377|ensembl:ENSP00000506350	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:o60885-1(display_long)|uniprotkb:Brd4L(isoform synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)|uniprotkb:Protein HUNK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830673|imex:IM-17412-4|dip:DIP-77340E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|intact:EBI-723869(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:NtNiOCyD5LQ1Cpz/GbGFpiDtakI	false	flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03122	uniprotkb:O60885-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-9345088|ensembl:ENSP00000263377|ensembl:ENSP00000506350	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:o60885-1(display_long)|uniprotkb:Brd4L(isoform synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)|uniprotkb:Protein HUNK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830692|imex:IM-17412-5|dip:DIP-77338E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N	ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|intact:EBI-723869(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:qkLODBGzIzeR7hkWcWZHt+Ng7t4	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03120	uniprotkb:Q96L91	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-399163|uniprotkb:O15411|uniprotkb:Q6P2F5|uniprotkb:Q8N8Q7|uniprotkb:Q8NE05|uniprotkb:Q96JK7|uniprotkb:Q9P230	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:ep400_human(display_long)|uniprotkb:p400 kDa SWI2/SNF2-related protein(gene name synonym)|uniprotkb:Domino homolog(gene name synonym)|uniprotkb:CAG repeat protein 32(gene name synonym)|uniprotkb:Trinucleotide repeat-containing gene 12 protein(gene name synonym)|uniprotkb:CAGH32(gene name synonym)|uniprotkb:KIAA1498(gene name synonym)|uniprotkb:KIAA1818(gene name synonym)|uniprotkb:TNRC12(gene name synonym)|uniprotkb:EP400(gene name)|psi-mi:EP400(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830711|imex:IM-17412-6|dip:DIP-188304E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_056224.3|ensembl:ENST00000389561|ensembl:ENSP00000374212|ensembl:ENSG00000183495|go:"GO:0000812"(Swr1 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0016787"(hydrolase activity)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0070615"|go:"GO:1990405"(protein antigen binding)|interpro:IPR000330(SNF2-related)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR027417|interpro:IPR031575|interpro:IPR038718|reactome:R-HSA-2559584|reactome:R-HSA-2559586|reactome:R-HSA-3214847|mint:Q96L91|dip:DIP-29915N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:DrQFsyaSlUxjJBloZPFrjXooDpU9606	rigid:gGg7gqZrMls+YsVUrRcbw9WTzKU	false	ha tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03122	uniprotkb:O60885-1	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-9345088|ensembl:ENSP00000263377|ensembl:ENSP00000506350	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:o60885-1(display_long)|uniprotkb:Brd4L(isoform synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)|uniprotkb:Protein HUNK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830634|imex:IM-17412-2|dip:DIP-188300E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N	ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|intact:EBI-723869(isoform-parent)	psi-mi:"MI:0465"(dip)	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:V0M9aLXgMcuWwB3lR0Qthf9weaA	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03122	uniprotkb:P41229	intact:EBI-7028618|uniprotkb:Q9WMH0|intact:MINT-95676	intact:EBI-1246541|uniprotkb:B4E3I2|uniprotkb:F5H3T1|ensembl:ENSP00000364550|uniprotkb:Q5JUX3|uniprotkb:Q5JUX4|uniprotkb:Q5JUX5|uniprotkb:Q7Z5S5|uniprotkb:B0QZ44|intact:EBI-28983825	psi-mi:ve2_bpv1(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kdm5c_human(display_long)|uniprotkb:KDM5C(gene name)|psi-mi:KDM5C(display_short)|uniprotkb:DXS1272E(gene name synonym)|uniprotkb:SMCX(gene name synonym)|uniprotkb:XE169(gene name synonym)|uniprotkb:Jumonji/ARID domain-containing protein 1C(gene name synonym)|uniprotkb:Protein SmcX(gene name synonym)|uniprotkb:Protein Xe169(gene name synonym)|uniprotkb:JARID1C(gene name synonym)|uniprotkb:Histone demethylase JARID1C(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(4) demethylase 5C"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:337052(bpv1)|taxid:337052(Bovine papillomavirus type 1)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830634|imex:IM-17412-2|dip:DIP-188300E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056740.1|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042504|rcsb pdb:1DBD|rcsb pdb:1JJH|rcsb pdb:2BOP|rcsb pdb:2JEU|rcsb pdb:2JEX|rcsb pdb:6BUS|interpro:IPR042503|dip:DIP-40866N	refseq:NP_001140174.1|refseq:NP_004178.2|refseq:NP_001269551.1|ensembl:ENSG00000126012(gene)|ensembl:ENST00000375401(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0034647"(histone H3-tri/di/monomethyl-lysine-4 demethylase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0051213"(dioxygenase activity)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013637(PLU-1-like)|refseq:XP_011529128.1|ensembl:ENST00000375379|ensembl:ENSP00000364528|ensembl:ENST00000375383|ensembl:ENSP00000364532|ensembl:ENSP00000364550|ensembl:ENST00000404049|ensembl:ENSP00000385394|ensembl:ENST00000452825|ensembl:ENSP00000445176|refseq:XP_005262092.1|interpro:IPR019786|interpro:IPR019787|interpro:IPR036431|mint:P41229|rcsb pdb:2JRZ|rcsb pdb:5FWJ|reactome:R-HSA-3214842|dip:DIP-39663N	psi-mi:"MI:0465"(dip)	comment:mint|function:"E2 regulates viral transcription and DNA replication. Binds to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory region. Can either activate or repress transcription depending on E2RE's position with regards to proximal promoter elements. Repression occurs by sterically hindering the assembly of the transcription initiation complex. The E1-E2 complex binds to the origin of DNA replication"|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:q+tFpuRXU8hhZnmVO8ZNtF5YS5o337052	rogid:sBtK/VaMcyTMcinoqnOqwBdl7TM9606	rigid:V0M9aLXgMcuWwB3lR0Qthf9weaA	false	ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03120	uniprotkb:O60885-1	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-9345088|ensembl:ENSP00000263377|ensembl:ENSP00000506350	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:o60885-1(display_long)|uniprotkb:Brd4L(isoform synonym)|uniprotkb:Long(isoform synonym)|uniprotkb:BRD4(gene name)|psi-mi:BRD4(display_short)|uniprotkb:HUNK1(gene name synonym)|uniprotkb:Protein HUNK1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830730|imex:IM-17412-7|dip:DIP-188303E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	ensembl:ENSG00000141867(gene)|ensembl:ENST00000263377(transcript)|ensembl:ENST00000679869(transcript)|intact:EBI-723869(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:tzQWCG/IwJWaOJ7XO+pXHkPVg+w9606	rigid:lREZzOhhTDmnjRHQDwsAnast2cE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P03120	uniprotkb:P41229	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-1246541|uniprotkb:B4E3I2|uniprotkb:F5H3T1|ensembl:ENSP00000364550|uniprotkb:Q5JUX3|uniprotkb:Q5JUX4|uniprotkb:Q5JUX5|uniprotkb:Q7Z5S5|uniprotkb:B0QZ44|intact:EBI-28983825	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:kdm5c_human(display_long)|uniprotkb:KDM5C(gene name)|psi-mi:KDM5C(display_short)|uniprotkb:DXS1272E(gene name synonym)|uniprotkb:SMCX(gene name synonym)|uniprotkb:XE169(gene name synonym)|uniprotkb:Jumonji/ARID domain-containing protein 1C(gene name synonym)|uniprotkb:Protein SmcX(gene name synonym)|uniprotkb:Protein Xe169(gene name synonym)|uniprotkb:JARID1C(gene name synonym)|uniprotkb:Histone demethylase JARID1C(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(4) demethylase 5C"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Smith et al. (2010)	pubmed:20133580|doi:10.1073/pnas.0914818107|imex:IM-17412	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15830730|imex:IM-17412-7|dip:DIP-188303E	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7	refseq:NP_001140174.1|refseq:NP_004178.2|refseq:NP_001269551.1|ensembl:ENSG00000126012(gene)|ensembl:ENST00000375401(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0034647"(histone H3-tri/di/monomethyl-lysine-4 demethylase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0051213"(dioxygenase activity)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013637(PLU-1-like)|refseq:XP_011529128.1|ensembl:ENST00000375379|ensembl:ENSP00000364528|ensembl:ENST00000375383|ensembl:ENSP00000364532|ensembl:ENSP00000364550|ensembl:ENST00000404049|ensembl:ENSP00000385394|ensembl:ENST00000452825|ensembl:ENSP00000445176|refseq:XP_005262092.1|interpro:IPR019786|interpro:IPR019787|interpro:IPR036431|mint:P41229|rcsb pdb:2JRZ|rcsb pdb:5FWJ|reactome:R-HSA-3214842|dip:DIP-39663N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/06	2017/08/10	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:sBtK/VaMcyTMcinoqnOqwBdl7TM9606	rigid:lREZzOhhTDmnjRHQDwsAnast2cE	false	flag tag:n-n	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)