#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00206-1	uniprotkb:Q9Y6Y9	intact:EBI-15745059|ensembl:ENSP00000363089	intact:EBI-1539247|uniprotkb:E5RJJ7|uniprotkb:B3Y6A5|ensembl:ENSP00000284818	psi-mi:o00206-1(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:ly96_human(display_long)|uniprotkb:Protein MD-2(gene name synonym)|uniprotkb:ESOP-1(gene name synonym)|uniprotkb:LY96(gene name)|psi-mi:LY96(display_short)|uniprotkb:ESOP1(gene name synonym)|uniprotkb:MD2(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Park et al. (2009)	pubmed:19252480|doi:10.1038/nature07830|imex:IM-17831	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15761957|imex:IM-17831-1|dip:DIP-80758E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|intact:EBI-528701(isoform-parent)	refseq:NP_001182726.1|refseq:NP_056179.3|dip:DIP-38571N|ensembl:ENSG00000154589(gene)|ensembl:ENST00000284818(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003172(MD-2-related lipid-recognition)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR039217|rcsb pdb:1T2Z|rcsb pdb:2E56|rcsb pdb:2E59|rcsb pdb:2Z65|rcsb pdb:3FXI|rcsb pdb:3ULA|rcsb pdb:4G8A|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2017/08/06	2017/08/10	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:mudJbbtrzlBXQeXgJNpkEmKeH589606	rigid:TtiqaKkRZcA5phCW2towoXnQrdw	false	binding-associated region:27-631	binding-associated region:19-160	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00206-1	uniprotkb:Q9Y6Y9	intact:EBI-15745059|ensembl:ENSP00000363089	intact:EBI-1539247|uniprotkb:E5RJJ7|uniprotkb:B3Y6A5|ensembl:ENSP00000284818	psi-mi:o00206-1(display_long)|uniprotkb:TLR4(gene name)|psi-mi:TLR4(display_short)|uniprotkb:hToll(gene name synonym)	psi-mi:ly96_human(display_long)|uniprotkb:Protein MD-2(gene name synonym)|uniprotkb:ESOP-1(gene name synonym)|uniprotkb:LY96(gene name)|psi-mi:LY96(display_short)|uniprotkb:ESOP1(gene name synonym)|uniprotkb:MD2(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Park et al. (2009)	pubmed:19252480|doi:10.1038/nature07830|imex:IM-17831	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15761979|imex:IM-17831-2|dip:DIP-80758E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136869(gene)|ensembl:ENST00000355622(transcript)|intact:EBI-528701(isoform-parent)	refseq:NP_001182726.1|refseq:NP_056179.3|dip:DIP-38571N|ensembl:ENSG00000154589(gene)|ensembl:ENST00000284818(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR003172(MD-2-related lipid-recognition)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR039217|rcsb pdb:1T2Z|rcsb pdb:2E56|rcsb pdb:2E59|rcsb pdb:2Z65|rcsb pdb:3FXI|rcsb pdb:3ULA|rcsb pdb:4G8A|reactome:R-HSA-1236974|reactome:R-HSA-140534|reactome:R-HSA-166016|reactome:R-HSA-166058|reactome:R-HSA-166166|reactome:R-HSA-2562578|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5686938|reactome:R-HSA-936964|reactome:R-HSA-937041|reactome:R-HSA-937072|reactome:R-HSA-9707616|reactome:R-HSA-975163	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini)|taxid:7111("Trichoplusia ni (Cabbage looper)")	-	2017/08/06	2017/08/10	rogid:4flqeyn60Q/64s8vQQHzlYDWz6w9606	rogid:mudJbbtrzlBXQeXgJNpkEmKeH589606	rigid:TtiqaKkRZcA5phCW2towoXnQrdw	false	binding-associated region:27-631	binding-associated region:19-160	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)