#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q28269 uniprotkb:P24723 intact:EBI-16222162 intact:EBI-2865850|uniprotkb:Q8NE03|uniprotkb:Q16246|uniprotkb:B4DJN5 psi-mi:ocln_canlf(display_long)|uniprotkb:OCLN(gene name)|psi-mi:OCLN(display_short) psi-mi:kpcl_human(display_long)|uniprotkb:PRKCH(gene name)|psi-mi:PRKCH(display_short)|uniprotkb:PKCL(gene name synonym)|uniprotkb:PRKCL(gene name synonym)|uniprotkb:PKC-L(gene name synonym)|uniprotkb:nPKC-eta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Suzuki et al. (2009) pubmed:19114660|doi:10.1073/pnas.0802741106|imex:IM-14396 taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16222179|imex:IM-14396-1|dip:DIP-103452E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR002958(Occludin)|interpro:IPR008253(Marvel)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR031176|dip:DIP-48669N|refseq:NP_001003195.1 go:"GO:0005911"(cell-cell junction)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0070528"(protein kinase C signaling)|ensembl:ENST00000332981|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0030168"(platelet activation)|refseq:NP_006246.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:2FK9|ensembl:ENSP00000450981|ensembl:ENST00000555082|reactome:R-HSA-114508|reactome:R-HSA-418597|go:"GO:0070062"(extracellular exosome)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|rcsb pdb:3TXO|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0007165"(signal transduction)|interpro:IPR027431|ensembl:ENSG00000027075|ensembl:ENSP00000329127|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0017160"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR034665|refseq:XP_016876947.1|dip:DIP-44588N|mint:MINT-3973608|go:"GO:0004674"(protein serine/threonine kinase activity)|interpro:IPR035892|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311" psi-mi:"MI:0465"(dip) - caution:This sequence has been withdrawn from Uniprot.|no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") - 2017/08/09 2017/08/10 rogid:bjTxkzYQUip8Rg4lwP906XdKa0Q9615 rogid:wqrydF3n2dujiiKKk44XmuQSuJk9606 rigid:SiRRvL4WiZpYQ1GbUXJ6gnybe9Y false - green fluorescent protein tag:0-0 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q28269 uniprotkb:P24723 intact:EBI-16222162 intact:EBI-2865850|uniprotkb:Q8NE03|uniprotkb:Q16246|uniprotkb:B4DJN5 psi-mi:ocln_canlf(display_long)|uniprotkb:OCLN(gene name)|psi-mi:OCLN(display_short) psi-mi:kpcl_human(display_long)|uniprotkb:PRKCH(gene name)|psi-mi:PRKCH(display_short)|uniprotkb:PKCL(gene name synonym)|uniprotkb:PRKCL(gene name synonym)|uniprotkb:PKC-L(gene name synonym)|uniprotkb:nPKC-eta(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Suzuki et al. (2009) pubmed:19114660|doi:10.1073/pnas.0802741106|imex:IM-14396 taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-16222234|imex:IM-14396-3|dip:DIP-103452E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR002958(Occludin)|interpro:IPR008253(Marvel)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR031176|dip:DIP-48669N|refseq:NP_001003195.1 go:"GO:0005911"(cell-cell junction)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0070528"(protein kinase C signaling)|ensembl:ENST00000332981|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0030168"(platelet activation)|refseq:NP_006246.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:2FK9|ensembl:ENSP00000450981|ensembl:ENST00000555082|reactome:R-HSA-114508|reactome:R-HSA-418597|go:"GO:0070062"(extracellular exosome)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|rcsb pdb:3TXO|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0007165"(signal transduction)|interpro:IPR027431|ensembl:ENSG00000027075|ensembl:ENSP00000329127|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0017160"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR034665|refseq:XP_016876947.1|dip:DIP-44588N|mint:MINT-3973608|go:"GO:0004674"(protein serine/threonine kinase activity)|interpro:IPR035892|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311" psi-mi:"MI:0465"(dip) - caution:This sequence has been withdrawn from Uniprot.|no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)") - 2017/08/09 2017/08/10 rogid:bjTxkzYQUip8Rg4lwP906XdKa0Q9615 rogid:wqrydF3n2dujiiKKk44XmuQSuJk9606 rigid:SiRRvL4WiZpYQ1GbUXJ6gnybe9Y false - green fluorescent protein tag:0-0 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24723 uniprotkb:Q16625-1 intact:EBI-2865850|uniprotkb:Q8NE03|uniprotkb:Q16246|uniprotkb:B4DJN5 intact:EBI-16115673|ensembl:ENSP00000347379|ensembl:ENSP00000379719|ensembl:ENSP00000505426|ensembl:ENSP00000505541|ensembl:ENSP00000506162 psi-mi:kpcl_human(display_long)|uniprotkb:PRKCH(gene name)|psi-mi:PRKCH(display_short)|uniprotkb:PKCL(gene name synonym)|uniprotkb:PRKCL(gene name synonym)|uniprotkb:PKC-L(gene name synonym)|uniprotkb:nPKC-eta(gene name synonym) psi-mi:q16625-1(display_long)|uniprotkb:OCLN(gene name)|psi-mi:OCLN(display_short)|uniprotkb:WT-OCLN(isoform synonym)|uniprotkb:"TM4(+)"(isoform synonym) psi-mi:"MI:0424"(protein kinase assay) Suzuki et al. (2009) pubmed:19114660|doi:10.1073/pnas.0802741106|imex:IM-14396 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0465"(DIP) intact:EBI-16222198|imex:IM-14396-2|dip:DIP-103453E - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005911"(cell-cell junction)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0070528"(protein kinase C signaling)|ensembl:ENST00000332981|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0030168"(platelet activation)|refseq:NP_006246.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:2FK9|ensembl:ENSP00000450981|ensembl:ENST00000555082|reactome:R-HSA-114508|reactome:R-HSA-418597|go:"GO:0070062"(extracellular exosome)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|rcsb pdb:3TXO|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0007165"(signal transduction)|interpro:IPR027431|ensembl:ENSG00000027075|ensembl:ENSP00000329127|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0017160"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR034665|refseq:XP_016876947.1|dip:DIP-44588N|mint:MINT-3973608|go:"GO:0004674"(protein serine/threonine kinase activity)|interpro:IPR035892|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311" ensembl:ENSG00000197822(gene)|ensembl:ENST00000355237(transcript)|ensembl:ENST00000396442(transcript)|ensembl:ENST00000680027(transcript)|ensembl:ENST00000681041(transcript)|ensembl:ENST00000681586(transcript)|intact:EBI-2903088(isoform-parent) psi-mi:"MI:0465"(dip) caution:This sequence has been withdrawn from Uniprot.|no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/09 2017/08/10 rogid:wqrydF3n2dujiiKKk44XmuQSuJk9606 rogid:RyZ9uIVH0TdDwlIFaGJJYbuHvmY9606 rigid:ekc9SZiRr/iXT6BRYmUEFqe3bK0 false - binding-associated region:378-522|glutathione s tranferase tag:n-n|mutation decreasing interaction:403-403|mutation decreasing interaction:404-404|mutation decreasing interaction:438-438|O-phospho-L-threonine:403-403|O-phospho-L-threonine:404-404|O-phospho-L-serine:408-408 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24723 uniprotkb:Q16625-1 intact:EBI-2865850|uniprotkb:Q8NE03|uniprotkb:Q16246|uniprotkb:B4DJN5 intact:EBI-16115673|ensembl:ENSP00000347379|ensembl:ENSP00000379719|ensembl:ENSP00000505426|ensembl:ENSP00000505541|ensembl:ENSP00000506162 psi-mi:kpcl_human(display_long)|uniprotkb:PRKCH(gene name)|psi-mi:PRKCH(display_short)|uniprotkb:PKCL(gene name synonym)|uniprotkb:PRKCL(gene name synonym)|uniprotkb:PKC-L(gene name synonym)|uniprotkb:nPKC-eta(gene name synonym) psi-mi:q16625-1(display_long)|uniprotkb:OCLN(gene name)|psi-mi:OCLN(display_short)|uniprotkb:WT-OCLN(isoform synonym)|uniprotkb:"TM4(+)"(isoform synonym) psi-mi:"MI:0096"(pull down) Suzuki et al. (2009) pubmed:19114660|doi:10.1073/pnas.0802741106|imex:IM-14396 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-16222253|imex:IM-14396-4|dip:DIP-103453E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005911"(cell-cell junction)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0070528"(protein kinase C signaling)|ensembl:ENST00000332981|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0030168"(platelet activation)|refseq:NP_006246.2|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR020454|interpro:IPR011009(Protein kinase-like)|interpro:IPR017892|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|rcsb pdb:2FK9|ensembl:ENSP00000450981|ensembl:ENST00000555082|reactome:R-HSA-114508|reactome:R-HSA-418597|go:"GO:0070062"(extracellular exosome)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|rcsb pdb:3TXO|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0007165"(signal transduction)|interpro:IPR027431|ensembl:ENSG00000027075|ensembl:ENSP00000329127|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0017160"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR034665|refseq:XP_016876947.1|dip:DIP-44588N|mint:MINT-3973608|go:"GO:0004674"(protein serine/threonine kinase activity)|interpro:IPR035892|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311" ensembl:ENSG00000197822(gene)|ensembl:ENST00000355237(transcript)|ensembl:ENST00000396442(transcript)|ensembl:ENST00000680027(transcript)|ensembl:ENST00000681041(transcript)|ensembl:ENST00000681586(transcript)|intact:EBI-2903088(isoform-parent) psi-mi:"MI:0465"(dip) caution:This sequence has been withdrawn from Uniprot.|no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/09 2017/08/10 rogid:wqrydF3n2dujiiKKk44XmuQSuJk9606 rogid:RyZ9uIVH0TdDwlIFaGJJYbuHvmY9606 rigid:ekc9SZiRr/iXT6BRYmUEFqe3bK0 false - binding-associated region:378-522|glutathione s tranferase tag:n-n - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)