#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HCH5	uniprotkb:Q9ERI2	intact:EBI-2690103|uniprotkb:B4DKW3|uniprotkb:Q9NXM1|uniprotkb:B4DJT5|uniprotkb:Q6TV07|uniprotkb:Q2YDA7|uniprotkb:Q6ZVC5|uniprotkb:B3KRS3|uniprotkb:Q9H768|uniprotkb:B4DQ26|uniprotkb:B7ZLX6|uniprotkb:Q8ND34|uniprotkb:Q96BJ2|uniprotkb:B7SA85|uniprotkb:B7ZLX7|uniprotkb:Q6ZN59|intact:EBI-28967480|ensembl:ENSP00000431701	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:sytl2_human(display_long)|uniprotkb:KIAA1597(gene name synonym)|uniprotkb:SGA72M(gene name synonym)|uniprotkb:SLP2(gene name synonym)|uniprotkb:SLP2A(gene name synonym)|uniprotkb:Breast cancer-associated antigen SGA-72M(gene name synonym)|uniprotkb:Exophilin-4(gene name synonym)|uniprotkb:SYTL2(gene name)|psi-mi:SYTL2(display_short)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734571|imex:IM-9482-1|dip:DIP-88136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000316356|ensembl:ENSP00000318803|ensembl:ENST00000359152|ensembl:ENSP00000352065|ensembl:ENST00000389958|ensembl:ENSP00000374608|ensembl:ENST00000389960|ensembl:ENSP00000374610|ensembl:ENST00000524452|ensembl:ENSP00000435238|ensembl:ENST00000525702|ensembl:ENSP00000432996|ensembl:ENST00000527523|ensembl:ENSP00000434010|ensembl:ENSP00000431701|ensembl:ENST00000529581|ensembl:ENSP00000435855|ensembl:ENST00000533892|ensembl:ENSP00000432144|refseq:XP_011543416.1|refseq:NP_001156423.1|refseq:NP_001156424.1|refseq:NP_001156425.1|refseq:NP_116561.1|refseq:NP_996812.1|refseq:NP_996813.1|ensembl:ENSG00000137501|refseq:XP_005274124.1|ensembl:ENSG00000137501(gene)|ensembl:ENST00000528231(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR027006|interpro:IPR035892|interpro:IPR041282|interpro:IPR043567|rcsb pdb:3BC1|refseq:NP_001276537.1|refseq:NP_001276538.1|refseq:NP_001276539.1	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wjE6VBu/hoq6qjhVm0icbKajXqc9606	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:TsOX3mdFvGEXYsyFrIM9WTRT43o	false	binding-associated region:10-62|glutathione s tranferase tag:n-n	binding-associated region:1-193|mutation increasing interaction:188-188,123-123	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q99P58	uniprotkb:Q9R0Q1-1	intact:EBI-11565917|uniprotkb:Q8CIX0|ensembl:ENSMUSP00000068349|ensembl:ENSMUSP00000112807|ensembl:ENSMUSP00000114094	intact:EBI-15734647|ensembl:ENSMUSP00000033608	psi-mi:rb27b_mouse(display_long)|uniprotkb:Rab27b(gene name)|psi-mi:Rab27b(display_short)	psi-mi:q9r0q1-1(display_long)|uniprotkb:Sytl4(gene name)|psi-mi:Sytl4(display_short)|uniprotkb:Slp4(gene name synonym)|uniprotkb:Granuphilin-a(isoform synonym)|uniprotkb:Exophilin-2(gene name synonym)|uniprotkb:Granuphilin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734656|imex:IM-9482-3|dip:DIP-88138E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076022.1|refseq:NP_001289727.1|refseq:NP_085031.3|ensembl:ENSMUSG00000024511(gene)|ensembl:ENSMUST00000069749(transcript)|ensembl:ENSMUST00000117692(transcript)|ensembl:ENSMUST00000121693(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:2IEY|rcsb pdb:2IEZ|rcsb pdb:2IF0|rcsb pdb:2ZET|reactome:R-MMU-114608|reactome:R-MMU-8873719|reactome:R-MMU-8876198|dip:DIP-46237N	ensembl:ENSMUSG00000031255(gene)|ensembl:ENSMUST00000033608(transcript)|intact:EBI-398341(isoform-parent)	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:R+P/aw+uO3tZcL5SFU6K0WwbOY410090	rogid:voOT0Zcw0j3aQFsanVwqwNCq9UE10090	rigid:nai1SGAYzhTisCRsHy/EXxsEV6U	false	mutation increasing interaction:123-123|mutation increasing interaction:188-188|mutation increasing interaction:188-188,123-123	binding-associated region:12-128|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9BV36	uniprotkb:Q99P58	intact:EBI-7042162|uniprotkb:B4DKW7|intact:MINT-3388002|uniprotkb:Q9HA71|uniprotkb:B3KSS2|uniprotkb:G5E9G5|ensembl:ENSP00000264605	intact:EBI-11565917|uniprotkb:Q8CIX0|ensembl:ENSMUSP00000068349|ensembl:ENSMUSP00000112807|ensembl:ENSMUSP00000114094	psi-mi:melph_human(display_long)|uniprotkb:MLPH(gene name)|psi-mi:MLPH(display_short)|uniprotkb:SLAC2A(gene name synonym)|uniprotkb:Exophilin-3(gene name synonym)|uniprotkb:Synaptotagmin-like protein 2a(gene name synonym)|uniprotkb:Slp homolog lacking C2 domains a(gene name synonym)	psi-mi:rb27b_mouse(display_long)|uniprotkb:Rab27b(gene name)|psi-mi:Rab27b(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734619|imex:IM-9482-2|dip:DIP-88140E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077006.1|refseq:NP_001035932.1|refseq:NP_001268402.1|refseq:NP_001268403.1|dip:DIP-44046N|ensembl:ENSG00000115648(gene)|ensembl:ENST00000264605(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017022"(myosin binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006788("Myelin-associated oligodendrocytic basic protein (MOBP)")|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR037442|interpro:IPR041282|mint:Q9BV36	refseq:NP_001076022.1|refseq:NP_001289727.1|refseq:NP_085031.3|ensembl:ENSMUSG00000024511(gene)|ensembl:ENSMUST00000069749(transcript)|ensembl:ENSMUST00000117692(transcript)|ensembl:ENSMUST00000121693(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:2IEY|rcsb pdb:2IEZ|rcsb pdb:2IF0|rcsb pdb:2ZET|reactome:R-MMU-114608|reactome:R-MMU-8873719|reactome:R-MMU-8876198|dip:DIP-46237N	psi-mi:"MI:0465"(dip)	comment:mint|function:Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A|function:"Defects in MLPH are a cause of Griscelli syndrome type-3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:g6+punuQGoilMzUlkOu+V73nUHc9606	rogid:R+P/aw+uO3tZcL5SFU6K0WwbOY410090	rigid:O9XVGwZ6gpZ8LSDwAhe/NLAh+ko	false	binding-associated region:13-129|glutathione s tranferase tag:n-n	mutation increasing interaction:188-188|mutation increasing interaction:188-188,123-123	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9HCH5	uniprotkb:Q9ERI2	intact:EBI-2690103|uniprotkb:B4DKW3|uniprotkb:Q9NXM1|uniprotkb:B4DJT5|uniprotkb:Q6TV07|uniprotkb:Q2YDA7|uniprotkb:Q6ZVC5|uniprotkb:B3KRS3|uniprotkb:Q9H768|uniprotkb:B4DQ26|uniprotkb:B7ZLX6|uniprotkb:Q8ND34|uniprotkb:Q96BJ2|uniprotkb:B7SA85|uniprotkb:B7ZLX7|uniprotkb:Q6ZN59|intact:EBI-28967480|ensembl:ENSP00000431701	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:sytl2_human(display_long)|uniprotkb:KIAA1597(gene name synonym)|uniprotkb:SGA72M(gene name synonym)|uniprotkb:SLP2(gene name synonym)|uniprotkb:SLP2A(gene name synonym)|uniprotkb:Breast cancer-associated antigen SGA-72M(gene name synonym)|uniprotkb:Exophilin-4(gene name synonym)|uniprotkb:SYTL2(gene name)|psi-mi:SYTL2(display_short)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0071"(molecular sieving)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734598|imex:IM-9482-9|dip:DIP-88136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000316356|ensembl:ENSP00000318803|ensembl:ENST00000359152|ensembl:ENSP00000352065|ensembl:ENST00000389958|ensembl:ENSP00000374608|ensembl:ENST00000389960|ensembl:ENSP00000374610|ensembl:ENST00000524452|ensembl:ENSP00000435238|ensembl:ENST00000525702|ensembl:ENSP00000432996|ensembl:ENST00000527523|ensembl:ENSP00000434010|ensembl:ENSP00000431701|ensembl:ENST00000529581|ensembl:ENSP00000435855|ensembl:ENST00000533892|ensembl:ENSP00000432144|refseq:XP_011543416.1|refseq:NP_001156423.1|refseq:NP_001156424.1|refseq:NP_001156425.1|refseq:NP_116561.1|refseq:NP_996812.1|refseq:NP_996813.1|ensembl:ENSG00000137501|refseq:XP_005274124.1|ensembl:ENSG00000137501(gene)|ensembl:ENST00000528231(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR027006|interpro:IPR035892|interpro:IPR041282|interpro:IPR043567|rcsb pdb:3BC1|refseq:NP_001276537.1|refseq:NP_001276538.1|refseq:NP_001276539.1	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wjE6VBu/hoq6qjhVm0icbKajXqc9606	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:TsOX3mdFvGEXYsyFrIM9WTRT43o	false	binding-associated region:10-62	binding-associated region:1-193	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9R0Q1-1	uniprotkb:Q9ERI2	intact:EBI-15734647|ensembl:ENSMUSP00000033608	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:q9r0q1-1(display_long)|uniprotkb:Sytl4(gene name)|psi-mi:Sytl4(display_short)|uniprotkb:Slp4(gene name synonym)|uniprotkb:Granuphilin-a(isoform synonym)|uniprotkb:Exophilin-2(gene name synonym)|uniprotkb:Granuphilin(gene name synonym)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734689|imex:IM-9482-4|dip:DIP-61004E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031255(gene)|ensembl:ENSMUST00000033608(transcript)|intact:EBI-398341(isoform-parent)	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:voOT0Zcw0j3aQFsanVwqwNCq9UE10090	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:7mqc5FWNGYyNCutrK0tnXelj9Js	false	ha tag:?-?	sufficient binding region:57-66|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99P58	uniprotkb:Q9HCH5	intact:EBI-11565917|uniprotkb:Q8CIX0|ensembl:ENSMUSP00000068349|ensembl:ENSMUSP00000112807|ensembl:ENSMUSP00000114094	intact:EBI-2690103|uniprotkb:B4DKW3|uniprotkb:Q9NXM1|uniprotkb:B4DJT5|uniprotkb:Q6TV07|uniprotkb:Q2YDA7|uniprotkb:Q6ZVC5|uniprotkb:B3KRS3|uniprotkb:Q9H768|uniprotkb:B4DQ26|uniprotkb:B7ZLX6|uniprotkb:Q8ND34|uniprotkb:Q96BJ2|uniprotkb:B7SA85|uniprotkb:B7ZLX7|uniprotkb:Q6ZN59|intact:EBI-28967480|ensembl:ENSP00000431701	psi-mi:rb27b_mouse(display_long)|uniprotkb:Rab27b(gene name)|psi-mi:Rab27b(display_short)	psi-mi:sytl2_human(display_long)|uniprotkb:KIAA1597(gene name synonym)|uniprotkb:SGA72M(gene name synonym)|uniprotkb:SLP2(gene name synonym)|uniprotkb:SLP2A(gene name synonym)|uniprotkb:Breast cancer-associated antigen SGA-72M(gene name synonym)|uniprotkb:Exophilin-4(gene name synonym)|uniprotkb:SYTL2(gene name)|psi-mi:SYTL2(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734801|imex:IM-9482-8|dip:DIP-88137E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001076022.1|refseq:NP_001289727.1|refseq:NP_085031.3|ensembl:ENSMUSG00000024511(gene)|ensembl:ENSMUST00000069749(transcript)|ensembl:ENSMUST00000117692(transcript)|ensembl:ENSMUST00000121693(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:2IEY|rcsb pdb:2IEZ|rcsb pdb:2IF0|rcsb pdb:2ZET|reactome:R-MMU-114608|reactome:R-MMU-8873719|reactome:R-MMU-8876198|dip:DIP-46237N	ensembl:ENST00000316356|ensembl:ENSP00000318803|ensembl:ENST00000359152|ensembl:ENSP00000352065|ensembl:ENST00000389958|ensembl:ENSP00000374608|ensembl:ENST00000389960|ensembl:ENSP00000374610|ensembl:ENST00000524452|ensembl:ENSP00000435238|ensembl:ENST00000525702|ensembl:ENSP00000432996|ensembl:ENST00000527523|ensembl:ENSP00000434010|ensembl:ENSP00000431701|ensembl:ENST00000529581|ensembl:ENSP00000435855|ensembl:ENST00000533892|ensembl:ENSP00000432144|refseq:XP_011543416.1|refseq:NP_001156423.1|refseq:NP_001156424.1|refseq:NP_001156425.1|refseq:NP_116561.1|refseq:NP_996812.1|refseq:NP_996813.1|ensembl:ENSG00000137501|refseq:XP_005274124.1|ensembl:ENSG00000137501(gene)|ensembl:ENST00000528231(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR027006|interpro:IPR035892|interpro:IPR041282|interpro:IPR043567|rcsb pdb:3BC1|refseq:NP_001276537.1|refseq:NP_001276538.1|refseq:NP_001276539.1	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:R+P/aw+uO3tZcL5SFU6K0WwbOY410090	rogid:wjE6VBu/hoq6qjhVm0icbKajXqc9606	rigid:9YPY6vkRaOfETUk+4BbXIedZ7bo	false	mutation increasing interaction:188-188,123-123	binding-associated region:10-62|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q9HCH5	uniprotkb:Q9ERI2	intact:EBI-2690103|uniprotkb:B4DKW3|uniprotkb:Q9NXM1|uniprotkb:B4DJT5|uniprotkb:Q6TV07|uniprotkb:Q2YDA7|uniprotkb:Q6ZVC5|uniprotkb:B3KRS3|uniprotkb:Q9H768|uniprotkb:B4DQ26|uniprotkb:B7ZLX6|uniprotkb:Q8ND34|uniprotkb:Q96BJ2|uniprotkb:B7SA85|uniprotkb:B7ZLX7|uniprotkb:Q6ZN59|intact:EBI-28967480|ensembl:ENSP00000431701	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:sytl2_human(display_long)|uniprotkb:KIAA1597(gene name synonym)|uniprotkb:SGA72M(gene name synonym)|uniprotkb:SLP2(gene name synonym)|uniprotkb:SLP2A(gene name synonym)|uniprotkb:Breast cancer-associated antigen SGA-72M(gene name synonym)|uniprotkb:Exophilin-4(gene name synonym)|uniprotkb:SYTL2(gene name)|psi-mi:SYTL2(display_short)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734780|imex:IM-9482-7|dip:DIP-88136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000316356|ensembl:ENSP00000318803|ensembl:ENST00000359152|ensembl:ENSP00000352065|ensembl:ENST00000389958|ensembl:ENSP00000374608|ensembl:ENST00000389960|ensembl:ENSP00000374610|ensembl:ENST00000524452|ensembl:ENSP00000435238|ensembl:ENST00000525702|ensembl:ENSP00000432996|ensembl:ENST00000527523|ensembl:ENSP00000434010|ensembl:ENSP00000431701|ensembl:ENST00000529581|ensembl:ENSP00000435855|ensembl:ENST00000533892|ensembl:ENSP00000432144|refseq:XP_011543416.1|refseq:NP_001156423.1|refseq:NP_001156424.1|refseq:NP_001156425.1|refseq:NP_116561.1|refseq:NP_996812.1|refseq:NP_996813.1|ensembl:ENSG00000137501|refseq:XP_005274124.1|ensembl:ENSG00000137501(gene)|ensembl:ENST00000528231(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR027006|interpro:IPR035892|interpro:IPR041282|interpro:IPR043567|rcsb pdb:3BC1|refseq:NP_001276537.1|refseq:NP_001276538.1|refseq:NP_001276539.1	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wjE6VBu/hoq6qjhVm0icbKajXqc9606	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:TsOX3mdFvGEXYsyFrIM9WTRT43o	false	binding-associated region:10-62	binding-associated region:1-193	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BV36	uniprotkb:Q9ERI2	intact:EBI-7042162|uniprotkb:B4DKW7|intact:MINT-3388002|uniprotkb:Q9HA71|uniprotkb:B3KSS2|uniprotkb:G5E9G5|ensembl:ENSP00000264605	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:melph_human(display_long)|uniprotkb:MLPH(gene name)|psi-mi:MLPH(display_short)|uniprotkb:SLAC2A(gene name synonym)|uniprotkb:Exophilin-3(gene name synonym)|uniprotkb:Synaptotagmin-like protein 2a(gene name synonym)|uniprotkb:Slp homolog lacking C2 domains a(gene name synonym)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734749|imex:IM-9482-6|dip:DIP-88139E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077006.1|refseq:NP_001035932.1|refseq:NP_001268402.1|refseq:NP_001268403.1|dip:DIP-44046N|ensembl:ENSG00000115648(gene)|ensembl:ENST00000264605(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0017022"(myosin binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006788("Myelin-associated oligodendrocytic basic protein (MOBP)")|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR037442|interpro:IPR041282|mint:Q9BV36	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	comment:mint|function:Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor protein MYO5A|function:"Defects in MLPH are a cause of Griscelli syndrome type-3 (GS3) [MIM:609227]. GS3 is a rare autosomal recessive disorder characterized by pigmentary dilution of the skin and hair, the presence of large clumps of pigment in hair shafts, and an accumulation of melanosomes in melanocytes, without other clinical manifestations"	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:g6+punuQGoilMzUlkOu+V73nUHc9606	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:OT4mteD/wAUTiXhXUFmaWG2T5ME	false	binding-associated region:13-129|glutathione s tranferase tag:n-n	mutation increasing interaction:188-188|mutation increasing interaction:188-188,123-123|binding-associated region:1-193	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9R0Q1-1	uniprotkb:Q9ERI2	intact:EBI-15734647|ensembl:ENSMUSP00000033608	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:q9r0q1-1(display_long)|uniprotkb:Sytl4(gene name)|psi-mi:Sytl4(display_short)|uniprotkb:Slp4(gene name synonym)|uniprotkb:Granuphilin-a(isoform synonym)|uniprotkb:Exophilin-2(gene name synonym)|uniprotkb:Granuphilin(gene name synonym)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734714|imex:IM-9482-5|dip:DIP-61004E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031255(gene)|ensembl:ENSMUST00000033608(transcript)|intact:EBI-398341(isoform-parent)	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:voOT0Zcw0j3aQFsanVwqwNCq9UE10090	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:7mqc5FWNGYyNCutrK0tnXelj9Js	false	binding-associated region:12-128|glutathione s tranferase tag:?-?	binding-associated region:1-193|mutation increasing interaction:188-188,123-123|mutation increasing interaction:123-123|mutation increasing interaction:188-188	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCH5	uniprotkb:Q9ERI2	intact:EBI-2690103|uniprotkb:B4DKW3|uniprotkb:Q9NXM1|uniprotkb:B4DJT5|uniprotkb:Q6TV07|uniprotkb:Q2YDA7|uniprotkb:Q6ZVC5|uniprotkb:B3KRS3|uniprotkb:Q9H768|uniprotkb:B4DQ26|uniprotkb:B7ZLX6|uniprotkb:Q8ND34|uniprotkb:Q96BJ2|uniprotkb:B7SA85|uniprotkb:B7ZLX7|uniprotkb:Q6ZN59|intact:EBI-28967480|ensembl:ENSP00000431701	intact:EBI-398172|ensembl:ENSMUSP00000034722|ensembl:ENSMUSP00000139310	psi-mi:sytl2_human(display_long)|uniprotkb:KIAA1597(gene name synonym)|uniprotkb:SGA72M(gene name synonym)|uniprotkb:SLP2(gene name synonym)|uniprotkb:SLP2A(gene name synonym)|uniprotkb:Breast cancer-associated antigen SGA-72M(gene name synonym)|uniprotkb:Exophilin-4(gene name synonym)|uniprotkb:SYTL2(gene name)|psi-mi:SYTL2(display_short)	psi-mi:rb27a_mouse(display_long)|uniprotkb:Rab27a(gene name)|psi-mi:Rab27a(display_short)	psi-mi:"MI:0096"(pull down)	Chavas et al. (2008)	pubmed:18940603|doi:10.1016/j.str.2008.07.015|imex:IM-9482	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15734826|imex:IM-9482-10|dip:DIP-88136E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000316356|ensembl:ENSP00000318803|ensembl:ENST00000359152|ensembl:ENSP00000352065|ensembl:ENST00000389958|ensembl:ENSP00000374608|ensembl:ENST00000389960|ensembl:ENSP00000374610|ensembl:ENST00000524452|ensembl:ENSP00000435238|ensembl:ENST00000525702|ensembl:ENSP00000432996|ensembl:ENST00000527523|ensembl:ENSP00000434010|ensembl:ENSP00000431701|ensembl:ENST00000529581|ensembl:ENSP00000435855|ensembl:ENST00000533892|ensembl:ENSP00000432144|refseq:XP_011543416.1|refseq:NP_001156423.1|refseq:NP_001156424.1|refseq:NP_001156425.1|refseq:NP_116561.1|refseq:NP_996812.1|refseq:NP_996813.1|ensembl:ENSG00000137501|refseq:XP_005274124.1|ensembl:ENSG00000137501(gene)|ensembl:ENST00000528231(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042470"(melanosome)|go:"GO:0070382"(exocytic vesicle)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR010911(Rab-binding)|interpro:IPR027006|interpro:IPR035892|interpro:IPR041282|interpro:IPR043567|rcsb pdb:3BC1|refseq:NP_001276537.1|refseq:NP_001276538.1|refseq:NP_001276539.1	refseq:NP_076124.1|ensembl:ENSMUSG00000032202(gene)|ensembl:ENSMUST00000034722(transcript)|ensembl:ENSMUST00000184146(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006605"(protein targeting)|go:"GO:0006887"(exocytosis)|go:"GO:0007596"(blood coagulation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031489"(myosin V binding)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033093"(Weibel-Palade body)|go:"GO:0036257"(multivesicular body organization)|go:"GO:0042470"(melanosome)|go:"GO:0043316"(cytotoxic T cell degranulation)|go:"GO:0043320"(natural killer cell degranulation)|go:"GO:0043473"(pigmentation)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051875"(pigment granule localization)|go:"GO:0051904"(pigment granule transport)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097278"(complement-dependent cytotoxicity)|go:"GO:1903307"(positive regulation of regulated secretory pathway)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903435"(positive regulation of constitutive secretory pathway)|go:"GO:1990182"(exosomal secretion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041837|rcsb pdb:3BC1|reactome:R-MMU-6798695|reactome:R-MMU-8873719|reactome:R-MMU-8876198|refseq:NP_001288159.1|refseq:NP_001288161.1|refseq:XP_006510843.1|dip:DIP-31054N	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/06	2017/08/10	rogid:wjE6VBu/hoq6qjhVm0icbKajXqc9606	rogid:IAq2IfXZTw2jSr+7LqNaJ03f/+g10090	rigid:TsOX3mdFvGEXYsyFrIM9WTRT43o	false	ha tag:n-n	sufficient binding region:57-66|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)