#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9P7A0 uniprotkb:P40381 intact:EBI-989427|ensemblfungi:"SPBP35G2.03c.1:pep" intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep" psi-mi:sgo1_schpo(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:SPBP35G2.03c(orf name) psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723227|imex:IM-22005-1|dip:DIP-195779E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBP35G2.03c(gene)|ensemblfungi:SPBP35G2.03c.1(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045144"(meiotic sister chromatid segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051455"(monopolar spindle attachment to meiosis I kinetochore)|go:"GO:0072687"(meiotic spindle)|go:"GO:0140311"(protein sequestering activity)|go:"GO:0140483"(kinetochore adaptor activity)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_595378.1|dip:DIP-36613N refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO psi-mi:"MI:0465"(dip) crc64:32F52DD0A1E0542A crc64:F505CC8AC5E75EAB full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:Cl0eHeFpiai8Kwj7IJQTY/MIgaE284812 rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812 rigid:jAT/aDef4TYzKGg1S1cssa4lFrg false mutation disrupting interaction strength:242-242|sufficient binding region:222-247 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P7A0 uniprotkb:P40381 intact:EBI-989427|ensemblfungi:"SPBP35G2.03c.1:pep" intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep" psi-mi:sgo1_schpo(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:SPBP35G2.03c(orf name) psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723268|imex:IM-22005-3|dip:DIP-195779E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBP35G2.03c(gene)|ensemblfungi:SPBP35G2.03c.1(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045144"(meiotic sister chromatid segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051455"(monopolar spindle attachment to meiosis I kinetochore)|go:"GO:0072687"(meiotic spindle)|go:"GO:0140311"(protein sequestering activity)|go:"GO:0140483"(kinetochore adaptor activity)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_595378.1|dip:DIP-36613N refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO psi-mi:"MI:0465"(dip) crc64:32F52DD0A1E0542A crc64:F505CC8AC5E75EAB full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)") - 2017/08/06 2017/08/10 rogid:Cl0eHeFpiai8Kwj7IJQTY/MIgaE284812 rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812 rigid:jAT/aDef4TYzKGg1S1cssa4lFrg false mutation disrupting interaction strength:242-242 green fluorescent protein tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5FBB7-6 uniprotkb:P83916 intact:EBI-989114|ensembl:ENSP00000410458 intact:EBI-78129|uniprotkb:P23197|ensembl:ENSP00000225603|ensembl:ENSP00000377060 psi-mi:q5fbb7-6(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:1AB(isoform synonym)|uniprotkb:SgoL1-A1(isoform synonym) psi-mi:cbx1_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short)|uniprotkb:CBX(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)|uniprotkb:p25beta(gene name synonym)|uniprotkb:HP1Hsbeta(gene name synonym) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723249|imex:IM-22005-2|dip:DIP-195783E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-989069(sgol1_human)|ensembl:ENSG00000129810(gene)|ensembl:ENST00000412997(transcript) ensembl:ENSG00000108468(gene)|ensembl:ENST00000225603(transcript)|ensembl:ENST00000393408(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83916|rcsb pdb:2FMM|rcsb pdb:3F2U|rcsb pdb:3Q6S|rcsb pdb:5T1G|rcsb pdb:6D07|rcsb pdb:6D08|reactome:R-HSA-9609690|refseq:NP_001120700.1|refseq:NP_006798.1|dip:DIP-28135N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:eGoNXNboUZb0xzdLaTgPrujYwkU9606 rogid:W2npW/vFRcuTkStKpknsAP69q6I9606 rigid:nbrUq1ZOAkm9/Hju0WvEX65XImQ false - sufficient binding region:112-185 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9P7A0 uniprotkb:P40381 intact:EBI-989427|ensemblfungi:"SPBP35G2.03c.1:pep" intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep" psi-mi:sgo1_schpo(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:SPBP35G2.03c(orf name) psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723347|imex:IM-22005-7|dip:DIP-195779E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPBP35G2.03c(gene)|ensemblfungi:SPBP35G2.03c.1(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045144"(meiotic sister chromatid segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051455"(monopolar spindle attachment to meiosis I kinetochore)|go:"GO:0072687"(meiotic spindle)|go:"GO:0140311"(protein sequestering activity)|go:"GO:0140483"(kinetochore adaptor activity)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_595378.1|dip:DIP-36613N refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO psi-mi:"MI:0465"(dip) crc64:32F52DD0A1E0542A crc64:F505CC8AC5E75EAB full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:Cl0eHeFpiai8Kwj7IJQTY/MIgaE284812 rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812 rigid:jAT/aDef4TYzKGg1S1cssa4lFrg false - sufficient binding region:216-328|mutation disrupting interaction strength:324-324 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P45973 uniprotkb:P45973 intact:EBI-78219|ensembl:ENSP00000209875|ensembl:ENSP00000401009|ensembl:ENSP00000449207|uniprotkb:B2R8T9 intact:EBI-78219|ensembl:ENSP00000209875|ensembl:ENSP00000401009|ensembl:ENSP00000449207|uniprotkb:B2R8T9 psi-mi:cbx5_human(display_long)|uniprotkb:CBX5(gene name)|psi-mi:CBX5(display_short)|uniprotkb:Heterochromatin protein 1 homolog alpha(gene name synonym)|uniprotkb:Antigen p25(gene name synonym)|uniprotkb:HP1A(gene name synonym) psi-mi:cbx5_human(display_long)|uniprotkb:CBX5(gene name)|psi-mi:CBX5(display_short)|uniprotkb:Heterochromatin protein 1 homolog alpha(gene name synonym)|uniprotkb:Antigen p25(gene name synonym)|uniprotkb:HP1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723369|imex:IM-22005-8|dip:DIP-195781E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|go:"GO:0030674"(protein-macromolecule adaptor activity)|mint:P45973|rcsb pdb:3FDT|rcsb pdb:3I3C|reactome:R-HSA-4551638|reactome:R-HSA-8953750|reactome:R-HSA-983231|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000094916(gene)|ensembl:ENST00000209875(transcript)|ensembl:ENST00000439541(transcript)|ensembl:ENST00000550411(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|refseq:NP_001120793.1|refseq:NP_001120794.1|refseq:NP_036249.1|dip:DIP-5986N go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|go:"GO:0030674"(protein-macromolecule adaptor activity)|mint:P45973|rcsb pdb:3FDT|rcsb pdb:3I3C|reactome:R-HSA-4551638|reactome:R-HSA-8953750|reactome:R-HSA-983231|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000094916(gene)|ensembl:ENST00000209875(transcript)|ensembl:ENST00000439541(transcript)|ensembl:ENST00000550411(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|refseq:NP_001120793.1|refseq:NP_001120794.1|refseq:NP_036249.1|dip:DIP-5986N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:yNQ+OVYYyR0Ls2cp6/xzBld1hyE9606 rogid:yNQ+OVYYyR0Ls2cp6/xzBld1hyE9606 rigid:m6Qv1lX0YXEuT9MxFYvki7uQi6Y false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q10428 uniprotkb:Q9P7A0 intact:EBI-989357|ensemblfungi:"SPCC188.02.1:pep" intact:EBI-989427|ensemblfungi:"SPBP35G2.03c.1:pep" psi-mi:2ad1_schpo(display_long)|uniprotkb:PP2A, B subunit, B' delta 1 isoform(gene name synonym)|uniprotkb:par1(gene name)|psi-mi:par1(display_short)|uniprotkb:pbp1(gene name synonym)|uniprotkb:SPCC188.02(orf name) psi-mi:sgo1_schpo(display_long)|uniprotkb:sgo1(gene name)|psi-mi:sgo1(display_short)|uniprotkb:SPBP35G2.03c(orf name) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723386|imex:IM-22005-9|dip:DIP-65108E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensemblfungi:SPCC188.02(gene)|ensemblfungi:SPCC188.02.1(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031030"(negative regulation of septation initiation signaling)|go:"GO:0031568"(mitotic G1 cell size control checkpoint signaling)|go:"GO:0032153"(cell division site)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0072687"(meiotic spindle)|go:"GO:0110085"(mitotic actomyosin contractile ring)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:NP_588206.1|reactome:R-SPO-198753|reactome:R-SPO-202670|dip:DIP-36612N|reactome:R-SPO-389513|reactome:R-SPO-6811558 ensemblfungi:SPBP35G2.03c(gene)|ensemblfungi:SPBP35G2.03c.1(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000939"(inner kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045144"(meiotic sister chromatid segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0051455"(monopolar spindle attachment to meiosis I kinetochore)|go:"GO:0072687"(meiotic spindle)|go:"GO:0140311"(protein sequestering activity)|go:"GO:0140483"(kinetochore adaptor activity)|go:"GO:1990813"(meiotic centromeric cohesion protection)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR038889|refseq:NP_595378.1|dip:DIP-36613N psi-mi:"MI:0465"(dip) crc64:A15FD882D516F88A crc64:32F52DD0A1E0542A full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:jSWj2r4tKur8yjSlGykRl02ZbcI284812 rogid:Cl0eHeFpiai8Kwj7IJQTY/MIgaE284812 rigid:WAYHVgihsKMYLqCof5zDyE4eS5w false - sufficient binding region:17-68 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P40381 uniprotkb:P40381 intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep" intact:EBI-926939|ensemblfungi:"SPAC664.01c.1:pep" psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name) psi-mi:swi6_schpo(display_long)|uniprotkb:swi6(gene name)|psi-mi:swi6(display_short)|uniprotkb:SPAC664.01c(orf name)|uniprotkb:SPAC824.10c(orf name) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723330|imex:IM-22005-6|dip:DIP-190927E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO refseq:NP_593449.1|dip:DIP-35736N|reactome:R-SPO-73772|reactome:R-SPO-983231|ensemblfungi:SPAC664.01c(gene)|ensemblfungi:SPAC664.01c.1(transcript)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006325"(chromatin organization)|go:"GO:0007533"(mating type switching)|go:"GO:0007534"(gene conversion at mating-type locus)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031934"(mating-type region heterochromatin)|go:"GO:0033696"(heterochromatin boundary formation)|go:"GO:0034507"(chromosome, centromeric outer repeat region)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044820"(mitotic telomere tethering at nuclear periphery)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0090053"(positive regulation of pericentric heterochromatin assembly)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:1990342"(heterochromatin island)|go:"GO:1990758"(mitotic sister chromatid biorientation)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779|interpro:IPR023780|rcsb pdb:1E0B|rcsb pdb:2RSO psi-mi:"MI:0465"(dip) crc64:F505CC8AC5E75EAB crc64:F505CC8AC5E75EAB full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812 rogid:EEISpq3oLJ9jyNp6870DB1Z3xCY284812 rigid:HadXPfhkagxW9F1f3E3Ok6zG1g0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FBB7-6 uniprotkb:P45973 intact:EBI-989114|ensembl:ENSP00000410458 intact:EBI-78219|ensembl:ENSP00000209875|ensembl:ENSP00000401009|ensembl:ENSP00000449207|uniprotkb:B2R8T9 psi-mi:q5fbb7-6(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:1AB(isoform synonym)|uniprotkb:SgoL1-A1(isoform synonym) psi-mi:cbx5_human(display_long)|uniprotkb:CBX5(gene name)|psi-mi:CBX5(display_short)|uniprotkb:Heterochromatin protein 1 homolog alpha(gene name synonym)|uniprotkb:Antigen p25(gene name synonym)|uniprotkb:HP1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723405|imex:IM-22005-10|dip:DIP-195782E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-989069(sgol1_human)|ensembl:ENSG00000129810(gene)|ensembl:ENST00000412997(transcript) go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|go:"GO:0030674"(protein-macromolecule adaptor activity)|mint:P45973|rcsb pdb:3FDT|rcsb pdb:3I3C|reactome:R-HSA-4551638|reactome:R-HSA-8953750|reactome:R-HSA-983231|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000094916(gene)|ensembl:ENST00000209875(transcript)|ensembl:ENST00000439541(transcript)|ensembl:ENST00000550411(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|refseq:NP_001120793.1|refseq:NP_001120794.1|refseq:NP_036249.1|dip:DIP-5986N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:eGoNXNboUZb0xzdLaTgPrujYwkU9606 rogid:yNQ+OVYYyR0Ls2cp6/xzBld1hyE9606 rigid:w9Ysp6gzVzSrLq17Okg8kWRezR4 false sufficient binding region:443-472|mutation disrupting interaction strength:453-453 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FBB7 uniprotkb:P67775 intact:EBI-989069|ensembl:ENSP00000263753|ensembl:ENSP00000414129|uniprotkb:Q5FBB4|uniprotkb:Q5FBB5|uniprotkb:Q5FBB6|uniprotkb:Q5FBB8|uniprotkb:Q8N579|uniprotkb:Q8WVL0|uniprotkb:Q9BVA8|uniprotkb:Q9H275|uniprotkb:Q588H5|intact:EBI-2555999 intact:EBI-712311|ensembl:ENSP00000418447|uniprotkb:P05323|uniprotkb:P13197 psi-mi:sgo1_human(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym) psi-mi:pp2aa_human(display_long)|uniprotkb:PPP2CA(gene name)|psi-mi:PPP2CA(display_short)|uniprotkb:Replication protein C(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15723290|imex:IM-22005-4|dip:DIP-195780E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000129810(gene)|ensembl:ENST00000263753(transcript)|ensembl:ENST00000421451(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR028321|interpro:IPR038889|mint:Q5FBB7|rcsb pdb:3FGA|rcsb pdb:3Q6S|rcsb pdb:4A0I|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001012409.1|refseq:NP_001012410.1|refseq:NP_001012411.1|refseq:NP_001012412.1|refseq:NP_001012413.1|refseq:NP_001186180.1|refseq:NP_001186181.1|refseq:NP_001186182.1|refseq:NP_001186183.1|refseq:NP_001186184.1|refseq:NP_001186185.1|refseq:NP_001186186.1|refseq:NP_612493.1|refseq:XP_011531675.1|refseq:XP_011531677.1|refseq:XP_011531678.1|refseq:XP_011531679.1|dip:DIP-36614N ensembl:ENSG00000113575(gene)|ensembl:ENST00000481195(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0010033"(response to organic substance)|go:"GO:0010288"(response to lead ion)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019932"(second-messenger-mediated signaling)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0040008"(regulation of growth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1904526"(regulation of microtubule binding)|go:"GO:1904528"(positive regulation of microtubule binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P67775|rcsb pdb:2IAE|rcsb pdb:2IE3|rcsb pdb:2IE4|rcsb pdb:2NPP|rcsb pdb:2NYL|rcsb pdb:2NYM|rcsb pdb:3C5W|rcsb pdb:3DW8|rcsb pdb:3FGA|rcsb pdb:3K7W|rcsb pdb:3P71|rcsb pdb:4I5L|rcsb pdb:4I5N|rcsb pdb:4IYP|rcsb pdb:4LAC|rcsb pdb:5W0W|rcsb pdb:6NTS|rcsb pdb:7CUN|rcsb pdb:7K36|reactome:R-HSA-113501|reactome:R-HSA-1295596|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2995383|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|rcsb pdb:3K7V|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|reactome:R-HSA-975957|refseq:NP_002706.1|dip:DIP-29395N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:rTa6IoM9PWfd6qOccSMZy1o0bBU9606 rogid:Zynydo3YUFioN2iUl6oR0nVJ4YY9606 rigid:ZeoECZb97y9M2CXoKF21wqiuLeU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5FBB7 uniprotkb:P45973 intact:EBI-989069|ensembl:ENSP00000263753|ensembl:ENSP00000414129|uniprotkb:Q5FBB4|uniprotkb:Q5FBB5|uniprotkb:Q5FBB6|uniprotkb:Q5FBB8|uniprotkb:Q8N579|uniprotkb:Q8WVL0|uniprotkb:Q9BVA8|uniprotkb:Q9H275|uniprotkb:Q588H5|intact:EBI-2555999 intact:EBI-78219|ensembl:ENSP00000209875|ensembl:ENSP00000401009|ensembl:ENSP00000449207|uniprotkb:B2R8T9 psi-mi:sgo1_human(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym) psi-mi:cbx5_human(display_long)|uniprotkb:CBX5(gene name)|psi-mi:CBX5(display_short)|uniprotkb:Heterochromatin protein 1 homolog alpha(gene name synonym)|uniprotkb:Antigen p25(gene name synonym)|uniprotkb:HP1A(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0465"(DIP) intact:EBI-15723290|imex:IM-22005-4|dip:DIP-195780E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000129810(gene)|ensembl:ENST00000263753(transcript)|ensembl:ENST00000421451(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0051177"(meiotic sister chromatid cohesion)|go:"GO:0051301"(cell division)|go:"GO:0071962"(mitotic sister chromatid cohesion, centromeric)|interpro:IPR011515(Shugoshin, C-terminal)|interpro:IPR011516(Shugoshin, N-terminal)|interpro:IPR028321|interpro:IPR038889|mint:Q5FBB7|rcsb pdb:3FGA|rcsb pdb:3Q6S|rcsb pdb:4A0I|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001012409.1|refseq:NP_001012410.1|refseq:NP_001012411.1|refseq:NP_001012412.1|refseq:NP_001012413.1|refseq:NP_001186180.1|refseq:NP_001186181.1|refseq:NP_001186182.1|refseq:NP_001186183.1|refseq:NP_001186184.1|refseq:NP_001186185.1|refseq:NP_001186186.1|refseq:NP_612493.1|refseq:XP_011531675.1|refseq:XP_011531677.1|refseq:XP_011531678.1|refseq:XP_011531679.1|dip:DIP-36614N go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|go:"GO:0030674"(protein-macromolecule adaptor activity)|mint:P45973|rcsb pdb:3FDT|rcsb pdb:3I3C|reactome:R-HSA-4551638|reactome:R-HSA-8953750|reactome:R-HSA-983231|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000094916(gene)|ensembl:ENST00000209875(transcript)|ensembl:ENST00000439541(transcript)|ensembl:ENST00000550411(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|refseq:NP_001120793.1|refseq:NP_001120794.1|refseq:NP_036249.1|dip:DIP-5986N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human)|taxid:9606(Homo sapiens) - 2017/08/06 2017/08/10 rogid:rTa6IoM9PWfd6qOccSMZy1o0bBU9606 rogid:yNQ+OVYYyR0Ls2cp6/xzBld1hyE9606 rigid:ZeoECZb97y9M2CXoKF21wqiuLeU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5FBB7-6 uniprotkb:P45973 intact:EBI-989114|ensembl:ENSP00000410458 intact:EBI-78219|ensembl:ENSP00000209875|ensembl:ENSP00000401009|ensembl:ENSP00000449207|uniprotkb:B2R8T9 psi-mi:q5fbb7-6(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:1AB(isoform synonym)|uniprotkb:SgoL1-A1(isoform synonym) psi-mi:cbx5_human(display_long)|uniprotkb:CBX5(gene name)|psi-mi:CBX5(display_short)|uniprotkb:Heterochromatin protein 1 homolog alpha(gene name synonym)|uniprotkb:Antigen p25(gene name synonym)|uniprotkb:HP1A(gene name synonym) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723308|imex:IM-22005-5|dip:DIP-195782E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-989069(sgol1_human)|ensembl:ENSG00000129810(gene)|ensembl:ENST00000412997(transcript) go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|go:"GO:0030674"(protein-macromolecule adaptor activity)|mint:P45973|rcsb pdb:3FDT|rcsb pdb:3I3C|reactome:R-HSA-4551638|reactome:R-HSA-8953750|reactome:R-HSA-983231|go:"GO:0032991"(protein-containing complex)|ensembl:ENSG00000094916(gene)|ensembl:ENST00000209875(transcript)|ensembl:ENST00000439541(transcript)|ensembl:ENST00000550411(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|refseq:NP_001120793.1|refseq:NP_001120794.1|refseq:NP_036249.1|dip:DIP-5986N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:eGoNXNboUZb0xzdLaTgPrujYwkU9606 rogid:yNQ+OVYYyR0Ls2cp6/xzBld1hyE9606 rigid:w9Ysp6gzVzSrLq17Okg8kWRezR4 false - mutation disrupting interaction strength:174-174|sufficient binding region:116-191 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q5FBB7-6 uniprotkb:Q13185 intact:EBI-989114|ensembl:ENSP00000410458 intact:EBI-78176|ensembl:ENSP00000336687|ensembl:ENSP00000379670|uniprotkb:Q96CD7|uniprotkb:Q99409|uniprotkb:Q9BVS3|uniprotkb:Q9P0Z6 psi-mi:q5fbb7-6(display_long)|uniprotkb:SGO1(gene name)|psi-mi:SGO1(display_short)|uniprotkb:SGOL1(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-85(gene name synonym)|uniprotkb:Shugoshin-like 1(gene name synonym)|uniprotkb:1AB(isoform synonym)|uniprotkb:SgoL1-A1(isoform synonym) psi-mi:cbx3_human(display_long)|uniprotkb:CBX3(gene name)|psi-mi:CBX3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:HECH(gene name synonym) psi-mi:"MI:0018"(two hybrid) Yamagishi et al. (2008) pubmed:18716626|doi:10.1038/nature07217|imex:IM-22005 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15723427|imex:IM-22005-11|dip:DIP-195784E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-989069(sgol1_human)|ensembl:ENSG00000129810(gene)|ensembl:ENST00000412997(transcript) go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|ensembl:ENSG00000122565(gene)|ensembl:ENST00000337620(transcript)|ensembl:ENST00000396386(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|mint:Q13185|rcsb pdb:2L11|rcsb pdb:3DM1|rcsb pdb:3KUP|rcsb pdb:3TZD|go:"GO:0005637"(nuclear inner membrane)|rcsb pdb:6HW2|reactome:R-HSA-427389|reactome:R-HSA-73772|reactome:R-HSA-8953750|rcsb pdb:5T1I|refseq:NP_009207.2|refseq:NP_057671.2|refseq:XP_005249668.1|dip:DIP-5985N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2017/08/06 2017/08/10 rogid:eGoNXNboUZb0xzdLaTgPrujYwkU9606 rogid:6L5OQHfxCBkmPV5Z0XihmXx4mFQ9606 rigid:kdStyTTv+DaaoAZzxzCYjaiLIbM false - sufficient binding region:116-183 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)