#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N6T7	intact:EBI-15693355	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	dip:DIP-59824N	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:h3k9ac(display_short)|psi-mi:EBI-15693355(display_long)	psi-mi:"MI:0406"(deacetylase assay)	Michishita et al. (2008)	pubmed:18337721|doi:10.1038/nature06736|imex:IM-17972	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15693358|imex:IM-17972-1|dip:DIP-189550E	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	-	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	rogid:D3ot6iukcb3D6XEqA0rBJ/pYBMs-2	rigid:jOdFXNohLMEnIHcDhxYF+TKodmA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)