#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43527	uniprotkb:Q920D5	intact:EBI-15691794	intact:EBI-1374296	psi-mi:casp1_rat(display_long)|uniprotkb:Casp1(gene name)|psi-mi:Casp1(display_short)|uniprotkb:Il1bc(gene name synonym)|uniprotkb:Il1bce(gene name synonym)|uniprotkb:Interleukin-1 beta convertase(gene name synonym)|uniprotkb:Interleukin-1 beta-converting enzyme(gene name synonym)|uniprotkb:p45(gene name synonym)	psi-mi:caspc_rat(display_long)|uniprotkb:Casp12(gene name)|psi-mi:Casp12(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Roy et al. (2008)	pubmed:18332441|doi:10.1073/pnas.0706658105|imex:IM-9185	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15691841|imex:IM-9185-1|dip:DIP-59323E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007494"(midgut development)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007613"(memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019900"(kinase binding)|go:"GO:0030324"(lung development)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046010"(positive regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051882"(mitochondrial depolarization)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070269"(pyroptosis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072558"(NLRP1 inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097179"(protease inhibitor complex)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0140447"(cytokine precursor processing)|go:"GO:0140448"(signaling receptor ligand precursor processing)|go:"GO:1901998"(toxin transport)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|reactome:R-RNO-168638|reactome:R-RNO-448706|reactome:R-RNO-5620971|dip:DIP-29840N|rgd:2274	rgd:621758|refseq:NP_569106.1|dip:DIP-29839N|go:"GO:0001554"(luteolysis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009409"(response to cold)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010663"(positive regulation of striated muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034059"(response to anoxia)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097264"(self proteolysis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035713	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:n96qFBmdUkFWLtSHkA6GmZblE4I10116	rogid:r83mkgvMdRYHvUN6CwWkSnhjaTM10116	rigid:y5Oc2WCEu3sUgpSWd8zwstqxY4A	false	flag tag:n-n	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q920D5	uniprotkb:Q920D5	intact:EBI-1374296	intact:EBI-1374296	psi-mi:caspc_rat(display_long)|uniprotkb:Casp12(gene name)|psi-mi:Casp12(display_short)	psi-mi:caspc_rat(display_long)|uniprotkb:Casp12(gene name)|psi-mi:Casp12(display_short)	psi-mi:"MI:0435"(protease assay)	Roy et al. (2008)	pubmed:18332441|doi:10.1073/pnas.0706658105|imex:IM-9185	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15691860|imex:IM-9185-2|dip:DIP-59324E	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:621758|refseq:NP_569106.1|dip:DIP-29839N|go:"GO:0001554"(luteolysis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009409"(response to cold)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010663"(positive regulation of striated muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034059"(response to anoxia)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097264"(self proteolysis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035713	rgd:621758|refseq:NP_569106.1|dip:DIP-29839N|go:"GO:0001554"(luteolysis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009409"(response to cold)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010663"(positive regulation of striated muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034059"(response to anoxia)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097264"(self proteolysis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035713	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:r83mkgvMdRYHvUN6CwWkSnhjaTM10116	rogid:r83mkgvMdRYHvUN6CwWkSnhjaTM10116	rigid:FqXudTkM7mQ1gzQV02adYeRZyGU	false	mutation disrupting interaction:319-319	mutation disrupting interaction:299-299	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)