#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8R418	uniprotkb:Q8R418	intact:EBI-2644051|uniprotkb:Q8R419	intact:EBI-2644051|uniprotkb:Q8R419	psi-mi:dicer_mouse(display_long)|uniprotkb:Dicer1(gene name)|psi-mi:Dicer1(display_short)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Mdcr(gene name synonym)|uniprotkb:Double-strand-specific ribonuclease mDCR-1(gene name synonym)	psi-mi:dicer_mouse(display_long)|uniprotkb:Dicer1(gene name)|psi-mi:Dicer1(display_short)|uniprotkb:Dicer(gene name synonym)|uniprotkb:Mdcr(gene name synonym)|uniprotkb:Double-strand-specific ribonuclease mDCR-1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Du et al. (2008)	pubmed:18268334|doi:10.1073/pnas.0711506105|imex:IM-9092	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15684706|imex:IM-9092-1|dip:DIP-59192E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001834"(trophectodermal cell proliferation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006396"(RNA processing)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010660"(regulation of muscle cell apoptotic process)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0014835"(myoblast differentiation involved in skeletal muscle regeneration)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036404"(obsolete conversion of ds siRNA to ss siRNA)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051225"(spindle assembly)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061548"(ganglion development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070173"(regulation of enamel mineralization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0071335"(hair follicle cell proliferation)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:2000628"(regulation of miRNA metabolic process)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000999(Ribonuclease III)|go:"GO:0021522"(spinal cord motor neuron differentiation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR044441|rcsb pdb:3C4B|rcsb pdb:3C4T|interpro:IPR038248|dip:DIP-29721N|reactome:R-MMU-203927|reactome:R-MMU-426486	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001834"(trophectodermal cell proliferation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0006396"(RNA processing)|go:"GO:0007284"(spermatogonial cell division)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010070"(zygote asymmetric cell division)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010660"(regulation of muscle cell apoptotic process)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0014835"(myoblast differentiation involved in skeletal muscle regeneration)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0016246"(RNA interference)|go:"GO:0016442"(RISC complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0021889"(olfactory bulb interneuron differentiation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031508"(pericentric heterochromatin assembly)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035280"(miRNA loading onto RISC)|go:"GO:0036404"(obsolete conversion of ds siRNA to ss siRNA)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048536"(spleen development)|go:"GO:0048565"(digestive tract development)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0048730"(epidermis morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0051225"(spindle assembly)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060119"(inner ear receptor cell development)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061548"(ganglion development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070173"(regulation of enamel mineralization)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0071335"(hair follicle cell proliferation)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|go:"GO:2000628"(regulation of miRNA metabolic process)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR000999(Ribonuclease III)|go:"GO:0021522"(spinal cord motor neuron differentiation)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR011907(Ribonuclease III, bacterial)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR044441|rcsb pdb:3C4B|rcsb pdb:3C4T|interpro:IPR038248|dip:DIP-29721N|reactome:R-MMU-203927|reactome:R-MMU-426486	psi-mi:"MI:0465"(dip)	-	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:562(ecolx)|taxid:562(Escherichia coli)	-	2017/08/05	2017/08/10	rogid:WTvPhOwCtJat0OjGAIn33JJ4ZEo10090	rogid:WTvPhOwCtJat0OjGAIn33JJ4ZEo10090	rigid:ieH8hGauii4B2lM7+xO4qi7mETE	false	binding-associated region:1638-1899	binding-associated region:1638-1899	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)