#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9UJ41-2 uniprotkb:Q9UL25 intact:EBI-6448458|ensembl:ENSP00000284957|ensembl:ENSP00000415815 intact:EBI-1056039|uniprotkb:Q14466|uniprotkb:Q569H3|ensembl:ENSP00000261263 psi-mi:q9uj41-2(display_long)|uniprotkb:RABGEF1(gene name)|psi-mi:RABGEF1(display_short)|uniprotkb:RABEX5(gene name synonym)|uniprotkb:RAP1(gene name synonym)|uniprotkb:Rabaptin-5-associated exchange factor for Rab5(gene name synonym)|uniprotkb:Rabex-5(gene name synonym) psi-mi:rab21_human(display_long)|uniprotkb:RAB21(gene name)|psi-mi:RAB21(display_short)|uniprotkb:KIAA0118(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Delprato et al. (2007) pubmed:17450153|doi:10.1038/nsmb1232|imex:IM-8665 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15633164|imex:IM-8665-2|dip:DIP-57403E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000450873(transcript)|ensembl:ENSG00000154710(gene)|ensembl:ENST00000284957(transcript)|intact:EBI-913954(isoform-parent)|uniprotkb:Q9UJ41-2(isoform-parent) refseq:NP_055814.1|ensembl:ENSG00000080371(gene)|ensembl:ENST00000261263(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0005829"(cytosol)|go:"GO:0012505"(endomembrane system)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019003"(GDP binding)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041833|mint:Q9UL25|rcsb pdb:1YZT|rcsb pdb:1YZU|rcsb pdb:1Z08|rcsb pdb:1Z0I|rcsb pdb:2OT3|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-29349N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:+MNigZ2IH2ogPAFA5YTYT0rGWYg9606 rogid:xeTabB1AP4LZcYhU4u/vZwwETnA9606 rigid:aY2IcaUYFU71noCuAEnEa7HotBs false sufficient binding region:132-397 sufficient binding region:16-183 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UJ41-2 uniprotkb:Q15276 intact:EBI-6448458|ensembl:ENSP00000284957|ensembl:ENSP00000415815 intact:EBI-447043|uniprotkb:O95369|uniprotkb:Q8IVX3|uniprotkb:B2RAG7|ensembl:ENSP00000445408 psi-mi:q9uj41-2(display_long)|uniprotkb:RABGEF1(gene name)|psi-mi:RABGEF1(display_short)|uniprotkb:RABEX5(gene name synonym)|uniprotkb:RAP1(gene name synonym)|uniprotkb:Rabaptin-5-associated exchange factor for Rab5(gene name synonym)|uniprotkb:Rabex-5(gene name synonym) psi-mi:rabe1_human(display_long)|uniprotkb:Rabaptin-5(gene name synonym)|uniprotkb:Rabaptin-5alpha(gene name synonym)|uniprotkb:Rabaptin-4(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-17(gene name synonym)|uniprotkb:RABEP1(gene name)|psi-mi:RABEP1(display_short)|uniprotkb:RABPT5(gene name synonym)|uniprotkb:RABPT5A(gene name synonym)|uniprotkb:RAB5EP(gene name synonym) psi-mi:"MI:0053"(fluorescence polarization spectroscopy) Delprato et al. (2007) pubmed:17450153|doi:10.1038/nsmb1232|imex:IM-8665 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15633185|imex:IM-8665-1|dip:DIP-57404E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000450873(transcript)|ensembl:ENSG00000154710(gene)|ensembl:ENST00000284957(transcript)|intact:EBI-913954(isoform-parent)|uniprotkb:Q9UJ41-2(isoform-parent) refseq:NP_001278510.1|refseq:NP_001077054.1|refseq:NP_004694.2|dip:DIP-29350N|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:1903441"(protein localization to ciliary membrane)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029880|rcsb pdb:1P4U|rcsb pdb:1TU3|rcsb pdb:1X79|rcsb pdb:4N3Y|rcsb pdb:4N3Z|rcsb pdb:4Q9U|reactome:R-HSA-8854214|ensembl:ENSG00000029725(gene)|ensembl:ENST00000537505(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:+MNigZ2IH2ogPAFA5YTYT0rGWYg9606 rogid:FDHgN8w6jbAPC3iQfeLY6sdLkrs9606 rigid:xb6wxhRUqVQLqHjdtpy8e1U48lo false sufficient binding region:401-462|alexa 488 label:404-404 sufficient binding region:551-862 - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)