#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y5U4	uniprotkb:P97260	intact:EBI-8503746|intact:MINT-8431157|uniprotkb:Q8TBI8|uniprotkb:A8K5W8|ensembl:ENSP00000245787	intact:EBI-11508251|uniprotkb:Q2WEK9	psi-mi:insi2_human(display_long)|uniprotkb:INSIG2(gene name)|psi-mi:INSIG2(display_short)	psi-mi:scap_crigr(display_long)|uniprotkb:SCAP(gene name)|psi-mi:SCAP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Radhakrishnan et al. (2007)	pubmed:17428920|doi:10.1073/pnas.0700899104|imex:IM-22801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10029(crigr)|taxid:10029("Cricetulus griseus (Chinese hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0465"(DIP)	intact:EBI-15631688|imex:IM-22801-1|dip:DIP-196804E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001308259.1|refseq:NP_001308260.1|refseq:NP_001308261.1|refseq:NP_001308262.1|refseq:NP_001308258.1|refseq:NP_057217.2|dip:DIP-60913N|ensembl:ENSG00000125629(gene)|ensembl:ENST00000245787(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0070542"(response to fatty acid)|interpro:IPR025929|rcsb pdb:4J82|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829	refseq:NP_001230965.1|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030120"(vesicle coat)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032934"(sterol binding)|go:"GO:0032936"(SREBP-SCAP complex)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036315"(cellular response to sterol)|go:"GO:0090110"(COPII-coated vesicle cargo loading)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR030225|interpro:IPR036322|go:"GO:0008203"(cholesterol metabolic process)|dip:DIP-60914N	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint	-	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2017/08/05	2017/08/10	rogid:u6hydxrFnhRfWQ4LuogzQ+P/S1I9606	rogid:QoHuAk4vAFqw3/i2H8XKda01FYs10029	rigid:lMevTQwLYxQEFYjGU38EMyePeJw	false	mutation disrupting interaction strength:115-115|mutation decreasing interaction strength:136-136|myc tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y5U4	uniprotkb:Q9Y5U4	intact:EBI-8503746|intact:MINT-8431157|uniprotkb:Q8TBI8|uniprotkb:A8K5W8|ensembl:ENSP00000245787	intact:EBI-8503746|intact:MINT-8431157|uniprotkb:Q8TBI8|uniprotkb:A8K5W8|ensembl:ENSP00000245787	psi-mi:insi2_human(display_long)|uniprotkb:INSIG2(gene name)|psi-mi:INSIG2(display_short)	psi-mi:insi2_human(display_long)|uniprotkb:INSIG2(gene name)|psi-mi:INSIG2(display_short)	psi-mi:"MI:0071"(molecular sieving)	Radhakrishnan et al. (2007)	pubmed:17428920|doi:10.1073/pnas.0700899104|imex:IM-22801	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0465"(DIP)	intact:EBI-15631713|imex:IM-22801-2|dip:DIP-196805E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001308259.1|refseq:NP_001308260.1|refseq:NP_001308261.1|refseq:NP_001308262.1|refseq:NP_001308258.1|refseq:NP_057217.2|dip:DIP-60913N|ensembl:ENSG00000125629(gene)|ensembl:ENST00000245787(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0070542"(response to fatty acid)|interpro:IPR025929|rcsb pdb:4J82|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829	refseq:NP_001308259.1|refseq:NP_001308260.1|refseq:NP_001308261.1|refseq:NP_001308262.1|refseq:NP_001308258.1|refseq:NP_057217.2|dip:DIP-60913N|ensembl:ENSG00000125629(gene)|ensembl:ENST00000245787(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0008142"(oxysterol binding)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0016126"(sterol biosynthetic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0036316"(SREBP-SCAP complex retention in endoplasmic reticulum)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042474"(middle ear morphogenesis)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060363"(cranial suture morphogenesis)|go:"GO:0070542"(response to fatty acid)|interpro:IPR025929|rcsb pdb:4J82|rcsb pdb:6M49|rcsb pdb:7ETW|reactome:R-HSA-1655829	psi-mi:"MI:0465"(dip)	comment:mint|comment:homomint	comment:mint|comment:homomint	full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2017/08/05	2017/08/10	rogid:u6hydxrFnhRfWQ4LuogzQ+P/S1I9606	rogid:u6hydxrFnhRfWQ4LuogzQ+P/S1I9606	rigid:Rfq0pIxSH3F9SpiLqGr0kYKEpeM	false	sufficient binding region:32-207	sufficient binding region:32-207	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)