#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P09038 uniprotkb:P11362-7 intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6 intact:EBI-15609945|ensembl:ENSP00000380280|ensembl:ENSP00000380297|ensembl:ENSP00000380302 psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym) psi-mi:p11362-7(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:III(isoform synonym)|uniprotkb:HBGFR(gene name synonym) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15609948|imex:IM-21617-3|dip:DIP-6046E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N ensembl:ENSG00000077782(gene)|ensembl:ENST00000397091(transcript)|ensembl:ENST00000397108(transcript)|ensembl:ENST00000397113(transcript)|intact:EBI-1028277(isoform-parent) psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606 rogid:7Oc/IvsdDauJcxKcLdjmGO9veEE9606 rigid:tZJAmI5KFqsQ0iCKyzeP7KpU2WQ false - fc-igg tag:?-?|sufficient binding region:22-374 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9GZV9 uniprotkb:O35082 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15609928|imex:IM-21617-2|dip:DIP-185470E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:nJtYO0o+LexiT5aAbqfpVKHxktY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P11362-14 uniprotkb:O35082 intact:EBI-6622185|ensembl:ENSP00000327229 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:p11362-14(display_long)|uniprotkb:I(isoform synonym)|uniprotkb:H3(isoform synonym)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:HBGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15609903|imex:IM-21617-1|dip:DIP-185465E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077782(gene)|ensembl:ENST00000326324(transcript)|intact:EBI-1028277(isoform-parent)|uniprotkb:P11362-14(isoform-parent) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:n4qnyR2rVZ7My1sM3u5KpsJAWAE9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:xzqyDCCS6AevoIQux6Ci2RPJH28 false fc-igg tag:?-?|sufficient binding region:22-285 sufficient binding region:1-980 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P11362-7 uniprotkb:Q9GZV9 intact:EBI-15609945|ensembl:ENSP00000380280|ensembl:ENSP00000380297|ensembl:ENSP00000380302 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 psi-mi:p11362-7(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:III(isoform synonym)|uniprotkb:HBGFR(gene name synonym) psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15610017|imex:IM-21617-6|dip:DIP-185471E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077782(gene)|ensembl:ENST00000397091(transcript)|ensembl:ENST00000397108(transcript)|ensembl:ENST00000397113(transcript)|intact:EBI-1028277(isoform-parent) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:7Oc/IvsdDauJcxKcLdjmGO9veEE9606 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rigid:s2yAtxrTsmqRl1OjFrlIEZeAPtY false fc-igg tag:?-?|sufficient binding region:22-374 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P11362-7 uniprotkb:O35082 intact:EBI-15609945|ensembl:ENSP00000380280|ensembl:ENSP00000380297|ensembl:ENSP00000380302 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:p11362-7(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:III(isoform synonym)|uniprotkb:HBGFR(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15610017|imex:IM-21617-6|dip:DIP-185471E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077782(gene)|ensembl:ENST00000397091(transcript)|ensembl:ENST00000397108(transcript)|ensembl:ENST00000397113(transcript)|intact:EBI-1028277(isoform-parent) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:7Oc/IvsdDauJcxKcLdjmGO9veEE9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:s2yAtxrTsmqRl1OjFrlIEZeAPtY false fc-igg tag:?-?|sufficient binding region:22-374 sufficient binding region:1-980 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P11362-7 uniprotkb:O35082 intact:EBI-15609945|ensembl:ENSP00000380280|ensembl:ENSP00000380297|ensembl:ENSP00000380302 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:p11362-7(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:III(isoform synonym)|uniprotkb:HBGFR(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15609992|imex:IM-21617-5|dip:DIP-185465E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077782(gene)|ensembl:ENST00000397091(transcript)|ensembl:ENST00000397108(transcript)|ensembl:ENST00000397113(transcript)|intact:EBI-1028277(isoform-parent) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:7Oc/IvsdDauJcxKcLdjmGO9veEE9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:UHcnvT3OAF4My+dPR+Q6YjfVSDE false fc-igg tag:?-?|sufficient binding region:22-374 sufficient binding region:1-980 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9GZV9 uniprotkb:O35082 intact:EBI-6594125|ensembl:ENSP00000237837|uniprotkb:Q4V758 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:fgf23_human(display_long)|uniprotkb:FGF23(gene name)|psi-mi:FGF23(display_short)|uniprotkb:HYPF(gene name synonym)|uniprotkb:Phosphatonin(gene name synonym)|uniprotkb:Tumor-derived hypophosphatemia-inducing factor(gene name synonym)|uniprotkb:UNQ3027/PRO9828(orf name) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0465"(DIP) intact:EBI-15609971|imex:IM-21617-4|dip:DIP-185470E - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000118972(gene)|ensembl:ENST00000237837(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005105"(type 1 fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010966"(regulation of phosphate transport)|go:"GO:0010980"(positive regulation of vitamin D 24-hydroxylase activity)|go:"GO:0030154"(cell differentiation)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0042369"(vitamin D catabolic process)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0055062"(phosphate ion homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|go:"GO:1904383"(response to sodium phosphate)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028304|rcsb pdb:2P39|rcsb pdb:5W21|rcsb pdb:6S22|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190322|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190374|reactome:R-HSA-190375|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-381426|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8853338|reactome:R-HSA-8957275|refseq:NP_065689.1|dip:DIP-58507N refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:Dfm7x2YNSSjehHi6KkwC/Gzpjsg9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:nJtYO0o+LexiT5aAbqfpVKHxktY false - sufficient binding region:1-980|fc-igg tag:c-c - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P11362-7 uniprotkb:P09038 intact:EBI-15609945|ensembl:ENSP00000380280|ensembl:ENSP00000380297|ensembl:ENSP00000380302 intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6 psi-mi:p11362-7(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:III(isoform synonym)|uniprotkb:HBGFR(gene name synonym) psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15610043|imex:IM-21617-7|dip:DIP-192033E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077782(gene)|ensembl:ENST00000397091(transcript)|ensembl:ENST00000397108(transcript)|ensembl:ENST00000397113(transcript)|intact:EBI-1028277(isoform-parent) refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:7Oc/IvsdDauJcxKcLdjmGO9veEE9606 rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606 rigid:QD4n14teVw2CBL6OL5svMcc9H0s false fc-igg tag:?-?|sufficient binding region:22-374 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P11362-7 uniprotkb:O35082 intact:EBI-15609945|ensembl:ENSP00000380280|ensembl:ENSP00000380297|ensembl:ENSP00000380302 intact:EBI-1570828|uniprotkb:O70175|uniprotkb:O70621|uniprotkb:B2RR78|ensembl:ENSMUSP00000077899 psi-mi:p11362-7(display_long)|uniprotkb:FGFR1(gene name)|psi-mi:FGFR1(display_short)|uniprotkb:BFGFR(gene name synonym)|uniprotkb:Basic fibroblast growth factor receptor 1(gene name synonym)|uniprotkb:CEK(gene name synonym)|uniprotkb:FGFBR(gene name synonym)|uniprotkb:FLG(gene name synonym)|uniprotkb:FLT2(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 2(gene name synonym)|uniprotkb:N-sam(gene name synonym)|uniprotkb:Proto-oncogene c-Fgr(gene name synonym)|uniprotkb:A(isoform synonym)|uniprotkb:III(isoform synonym)|uniprotkb:HBGFR(gene name synonym) psi-mi:klot_mouse(display_long)|uniprotkb:Kl(gene name)|psi-mi:Kl(display_short) psi-mi:"MI:0096"(pull down) Urakawa et al. (2006) pubmed:17086194|doi:10.1038/nature05315|imex:IM-21617 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0465"(DIP) intact:EBI-15610043|imex:IM-21617-7|dip:DIP-192033E - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000077782(gene)|ensembl:ENST00000397091(transcript)|ensembl:ENST00000397108(transcript)|ensembl:ENST00000397113(transcript)|intact:EBI-1028277(isoform-parent) refseq:NP_038851.2|dip:DIP-39894N|ensembl:ENSMUSG00000058488(gene)|ensembl:ENSMUST00000078856(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0004566"(beta-glucuronidase activity)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0042421"(norepinephrine biosynthetic process)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0090080"(positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway)|interpro:IPR001360(Glycoside hydrolase, family 1)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR028546|interpro:IPR033132|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-190374|reactome:R-MMU-5654219|reactome:R-MMU-5654687|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654726|reactome:R-MMU-5673001|reactome:R-MMU-6811558 psi-mi:"MI:0465"(dip) - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2017/08/05 2017/08/10 rogid:7Oc/IvsdDauJcxKcLdjmGO9veEE9606 rogid:rj/Wc7xYgFTXmP6J9nzgH5rJuhc10090 rigid:QD4n14teVw2CBL6OL5svMcc9H0s false fc-igg tag:?-?|sufficient binding region:22-374 sufficient binding region:1-980 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)