#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P30273 uniprotkb:O76036 intact:EBI-515289|uniprotkb:Q5VTW4|ensembl:ENSP00000289902 intact:EBI-13915737|uniprotkb:B0V3L2|uniprotkb:B0V3L3|uniprotkb:B0V3L4|uniprotkb:B0V3L5|uniprotkb:B8JL03|uniprotkb:O76016|uniprotkb:O76017|uniprotkb:O76018|ensembl:ENSP00000478507|ensembl:ENSP00000481971|ensembl:ENSP00000482423|ensembl:ENSP00000483452|ensembl:ENSP00000484221|ensembl:ENSP00000484520 psi-mi:fcerg_human(display_long)|uniprotkb:IgE Fc receptor subunit gamma(gene name synonym)|uniprotkb:Fc-epsilon RI-gamma(gene name synonym)|uniprotkb:FCER1G(gene name)|psi-mi:FCER1G(display_short)|uniprotkb:Fc receptor gamma-chain(gene name synonym) psi-mi:nctr1_human(display_long)|uniprotkb:NCR1(gene name)|psi-mi:NCR1(display_short)|uniprotkb:LY94(gene name synonym)|uniprotkb:Lymphocyte antigen 94 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p46-related protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cantoni et al. (1999) pubmed:10049942|imex:IM-25738 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14037991|imex:IM-25738-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004097.1|dip:DIP-29514N|ensembl:ENSG00000158869(gene)|ensembl:ENST00000289902(transcript)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002292"(T cell differentiation involved in immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010543"(regulation of platelet activation)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019767"(IgE receptor activity)|go:"GO:0019863"(IgE binding)|go:"GO:0019864"(IgG binding)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031623"(receptor internalization)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032998"(Fc-epsilon receptor I complex)|go:"GO:0038094"(Fc-gamma receptor signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038156"(interleukin-3-mediated signaling pathway)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR021663|interpro:IPR042340|mint:P30273|reactome:R-HSA-114604|reactome:R-HSA-202733|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|go:"GO:0042742"(defense response to bacterium)|reactome:R-HSA-2871837|reactome:R-HSA-5621480|reactome:R-HSA-6798695|reactome:R-HSA-75892|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response) refseq:NP_001138929.2|refseq:NP_001138930.2|refseq:NP_001229285.1|refseq:NP_001229286.1|refseq:NP_004820.2|ensembl:ENSG00000273535(gene)|ensembl:ENSG00000275156(gene)|ensembl:ENSG00000278362(gene)|ensembl:ENST00000610621(transcript)|ensembl:ENST00000612896(transcript)|ensembl:ENST00000615622(transcript)|ensembl:ENST00000617154(transcript)|ensembl:ENST00000617784(transcript)|ensembl:ENST00000619077(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0042269"(regulation of natural killer cell mediated cytotoxicity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1OLL|rcsb pdb:1P6F|rcsb pdb:6IAP|reactome:R-HSA-198933 - - - figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells) - 2017/04/20 2017/05/05 rogid:sYW44kyg+jmeUmR9vWSSPdyq4N49606 rogid:FzfU+jTvlPUvjgqpbZjkL7NYZt09606 rigid:vkLzbhFfmHLIAeDUn00BIEQKuuA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43914 uniprotkb:O95944 intact:EBI-2214794|uniprotkb:Q6FGA5|uniprotkb:Q9UMT3|uniprotkb:A8K2X0|uniprotkb:F5H389|ensembl:ENSP00000262629 intact:EBI-14058375|uniprotkb:Q9H562|uniprotkb:Q9H563|uniprotkb:Q9H564|uniprotkb:Q9UMT1|uniprotkb:Q9UMT2|ensembl:ENSP00000362181 psi-mi:tyobp_human(display_long)|uniprotkb:TYROBP(gene name)|psi-mi:TYROBP(display_short)|uniprotkb:DAP12(gene name synonym)|uniprotkb:KARAP(gene name synonym)|uniprotkb:DNAX-activation protein 12(gene name synonym)|uniprotkb:Killer-activating receptor-associated protein(gene name synonym) psi-mi:nctr2_human(display_long)|uniprotkb:NCR2(gene name)|psi-mi:NCR2(display_short)|uniprotkb:Lymphocyte antigen 95 homolog(gene name synonym)|uniprotkb:NK cell-activating receptor(gene name synonym)|uniprotkb:Natural killer cell p44-related protein(gene name synonym)|uniprotkb:LY95(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Cantoni et al. (1999) pubmed:10049942|imex:IM-25738 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-14058371|imex:IM-25738-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001166985.1|refseq:NP_003323.1|refseq:NP_937758.1|ensembl:ENSG00000011600(gene)|ensembl:ENST00000262629(transcript)|go:"GO:0002222"(stimulatory killer cell immunoglobulin-like receptor signaling pathway)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002274"(myeloid leukocyte activation)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0030900"(forebrain development)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034241"(positive regulation of macrophage fusion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0046872"(metal ion binding)|go:"GO:0048678"(response to axon injury)|go:"GO:0050821"(protein stabilization)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0110090"(positive regulation of hippocampal neuron apoptotic process)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902685"(positive regulation of receptor localization to synapse)|go:"GO:1904151"(positive regulation of microglial cell mediated cytotoxicity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR026200|rcsb pdb:2L34|rcsb pdb:2L35|rcsb pdb:4WO1|rcsb pdb:4WOL|reactome:R-HSA-198933|reactome:R-HSA-2172127|reactome:R-HSA-2424491|reactome:R-HSA-391160|reactome:R-HSA-416700|reactome:R-HSA-6798695 refseq:NP_001186438.1|refseq:NP_001186439.1|refseq:NP_004819.2|ensembl:ENSG00000096264(gene)|ensembl:ENST00000373089(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006968"(cellular defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0038023"(signaling receptor activity)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1HKF|reactome:R-HSA-198933|reactome:R-HSA-2172127 - - - figure legend:2 B/C|agonist:pervanadate- a phosphatase inhibitor|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-nk_cells)|taxid:9606(human-Natural Killer cells) - 2017/04/20 2017/05/08 rogid:mu2fXvaw0UH/mPPCFw8kG4XJkGk9606 rogid:z5C/bFbh63q0D4Jb8o+gfB7OVsc9606 rigid:6P7BTrrJKtt3JEPXD0U2yy+mpO8 false O4'-phospho-L-tyrosine:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)