#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QXT8	uniprotkb:P49768	intact:EBI-11720427|uniprotkb:Q924L0|uniprotkb:Q99PH9|uniprotkb:Q99PI0|uniprotkb:Q99PI2|uniprotkb:Q99PI3|uniprotkb:Q9JHZ5|ensembl:ENSMUSP00000099504	intact:EBI-297277|ensembl:ENSP00000326366|uniprotkb:O95465|uniprotkb:Q14762|uniprotkb:Q15719|uniprotkb:Q15720|uniprotkb:Q96P33|uniprotkb:Q9UIF0|uniprotkb:B2R6D3	psi-mi:csen_mouse(display_long)|uniprotkb:A-type potassium channel modulatory protein 3(gene name synonym)|uniprotkb:Kcnip3(gene name)|psi-mi:Kcnip3(display_short)|uniprotkb:Csen(gene name synonym)|uniprotkb:Dream(gene name synonym)|uniprotkb:Kchip3(gene name synonym)|uniprotkb:DRE-antagonist modulator(gene name synonym)|uniprotkb:Kv channel-interacting protein 3(gene name synonym)	psi-mi:psn1_human(display_long)|uniprotkb:PSEN1(gene name)|psi-mi:PSEN1(display_short)|uniprotkb:AD3(gene name synonym)|uniprotkb:PS1(gene name synonym)|uniprotkb:PSNL1(gene name synonym)|uniprotkb:Protein S182(gene name synonym)	psi-mi:"MI:0017"(classical fluorescence spectroscopy)	Pham et al. (2016)	imex:IM-25306|pubmed:27009418	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-11720536|imex:IM-25306-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104801.1|refseq:NP_001277934.1|refseq:NP_062763.2|ensembl:ENSMUSG00000079056(gene)|ensembl:ENSMUST00000103215(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005267"(potassium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048265"(response to pain)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR028846|rcsb pdb:2JUL|reactome:R-MMU-5576894	ensembl:ENST00000324501(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|ensembl:ENSG00000080815(gene)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49768|rcsb pdb:2KR6|rcsb pdb:4UIS|rcsb pdb:5A63|rcsb pdb:5FN2|rcsb pdb:5FN3|rcsb pdb:5FN4|rcsb pdb:5FN5|rcsb pdb:6IDF|rcsb pdb:6IYC|rcsb pdb:6LQG|rcsb pdb:6LR4|rcsb pdb:7C9I|rcsb pdb:7D8X|reactome:R-HSA-1251985|reactome:R-HSA-1474228|reactome:R-HSA-193692|reactome:R-HSA-205043|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-9017802|go:"GO:0015871"(choline transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0015031"(protein transport)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|refseq:NP_000012.1|refseq:NP_015557.2|refseq:XP_011535273.1|refseq:XP_011535274.1|refseq:XP_011535275.1|refseq:XP_011535276.1|refseq:XP_005267921.1|refseq:XP_005267923.1|dip:DIP-1134N	-	-	-	figure legend:t1 f2|comment:"HL9 binds to Ca2+DREAM and Mg2+Ca2+DREAM with a similar Kd of 0.6 μm. In the absence of Ca2+, a weak interaction was determined for binding of HL9 to ApoDREAM (Kd = 183 ± 12 μm), whereas the Kd value for HL9 association with Mg2+DREAM was found to be 29 ± 2 μm."|comment:"To investigate the mechanism by which Ca2+ binding to EF-hands 3 and 4 in DREAM mediates DREAM and HL9 interactions, binding of HL9 to DREAM-E234Q and DREAM-E186Q were studied. Titration data demonstrate that HL9 binds to DREAM-E234Q in the presence of Ca2+ and Ca2+/Mg2+ with a Kd of 8 μm, whereas a weaker binding (Kd = 32 μm) was observed for DREAM-E186Q mutant (Table 1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.6x10^-6(molar)	2016/06/06	2016/06/06	rogid:0OIRaEhd9R9sc3FUqERu1H8mOy410090	rogid:KJwrVRHoYA67u579QC5EZ0Owjoc9606	rigid:1SR4AVG+xPtv3ZTY6wMs5w20cN8	false	mutation decreasing interaction:234-234|mutation decreasing interaction:186-186|binding-associated region:65-161	binding-associated region:445-467	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)