#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14004	uniprotkb:O75909	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11582091|wwpdb:5efq|imex:IM-25057-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	-	-	-	3d-resolution:2A|3d-r-factors:Rworking 19.4% Rfree 24.7%|figure legend:Supp. Table 1|comment:Crystals were grown in the presence of ADP, aluminum fluoride, and the substrate peptide P-pS-YSPTSP-pS-YSPT -  no crystallographic density was observed for the substrate peptide but only for the ADP-AlF3 transition state mimic and two magnesium ions.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/02/16	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rigid:vV/HIiktpzaD03uju3wvgNwGVcs	false	sufficient binding region:694-1039(IPR011009)	sufficient binding region:1-267	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q14004	uniprotkb:O75909	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11582177|imex:IM-25057-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	-	-	-	figure legend:Supp Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2016/02/16	2016/02/18	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rigid:vV/HIiktpzaD03uju3wvgNwGVcs	false	sufficient binding region:694-1039(IPR011009)	sufficient binding region:1-267(IPR013763)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q14004	uniprotkb:O75909	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11582230|imex:IM-25057-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	-	-	-	figure legend:Supp Fig. 1A, 5B, 5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2016/02/16	2016/02/18	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rigid:vV/HIiktpzaD03uju3wvgNwGVcs	false	sufficient binding region:694-1039(IPR011009)	sufficient binding region:1-267(IPR013763)	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O75909	uniprotkb:Q14004	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598940|imex:IM-25057-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rigid:YVmOUypzUlq3R/FaCRGAPKFkpek	false	sufficient binding region:1-267	sufficient binding region:673-1039(IPR011009)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:P24928-1	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-11618161	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:p24928-1(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:POLR2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598940|imex:IM-25057-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	intact:EBI-295301(isoform-parent)	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606	rigid:YVmOUypzUlq3R/FaCRGAPKFkpek	false	sufficient binding region:1-267	O-phospho-L-serine:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:Q13526	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598940|imex:IM-25057-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rigid:YVmOUypzUlq3R/FaCRGAPKFkpek	false	sufficient binding region:1-267	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:Q9NYV4	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-1055431|uniprotkb:A7E2B2|uniprotkb:O94978|uniprotkb:B4DYX4|uniprotkb:B9EIQ6|ensembl:ENSP00000398880	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:cdk12_human(display_long)|uniprotkb:Cdc2-related kinase, arginine/serine-rich(gene name synonym)|uniprotkb:CDK12(gene name)|psi-mi:CDK12(display_short)|uniprotkb:CRK7(gene name synonym)|uniprotkb:KIAA0904(gene name synonym)|uniprotkb:CRKRS(gene name synonym)|uniprotkb:Cell division cycle 2-related protein kinase 7(gene name synonym)|uniprotkb:Cell division protein kinase 12(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598967|imex:IM-25057-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	refseq:NP_055898.1|refseq:NP_057591.2|ensembl:ENST00000430627|ensembl:ENSP00000407720|ensembl:ENSP00000398880|ensembl:ENSG00000167258(gene)|ensembl:ENST00000447079(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXK|reactome:R-HSA-6796648|dip:DIP-39768N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4C, 6B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:qffna20nodTj1PmlReV/ACpVcqs9606	rigid:P4Jw5gEsdLbxOx0b5jl4azUMgRQ	false	sufficient binding region:1-267	sufficient binding region:696-1082(IPR011009)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:P24928-1	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-11618161	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:p24928-1(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:POLR2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598967|imex:IM-25057-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	intact:EBI-295301(isoform-parent)	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4C, 6B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606	rigid:P4Jw5gEsdLbxOx0b5jl4azUMgRQ	false	sufficient binding region:1-267	sufficient binding region:1587-1970(IPR000684)|O-phospho-L-serine:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:Q14004	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598988|imex:IM-25057-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4C, 6B, Supp. Fig. 1C, 5D, 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rigid:jv5TQVOm2kVJ3jYXj4N1hHAF0Nw	false	sufficient binding region:1-267	sufficient binding region:673-1039(IPR011009)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:P24928-1	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-11618161	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:p24928-1(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:POLR2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11598988|imex:IM-25057-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	intact:EBI-295301(isoform-parent)	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4C, 6B, Supp. Fig. 1C, 5D, 5E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606	rigid:jv5TQVOm2kVJ3jYXj4N1hHAF0Nw	false	sufficient binding region:1-267	sufficient binding region:1587-1970(IPR000684)|O-phospho-L-serine:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:Q9NYV4	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-1055431|uniprotkb:A7E2B2|uniprotkb:O94978|uniprotkb:B4DYX4|uniprotkb:B9EIQ6|ensembl:ENSP00000398880	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:cdk12_human(display_long)|uniprotkb:Cdc2-related kinase, arginine/serine-rich(gene name synonym)|uniprotkb:CDK12(gene name)|psi-mi:CDK12(display_short)|uniprotkb:CRK7(gene name synonym)|uniprotkb:KIAA0904(gene name synonym)|uniprotkb:CRKRS(gene name synonym)|uniprotkb:Cell division cycle 2-related protein kinase 7(gene name synonym)|uniprotkb:Cell division protein kinase 12(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11599017|imex:IM-25057-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	refseq:NP_055898.1|refseq:NP_057591.2|ensembl:ENST00000430627|ensembl:ENSP00000407720|ensembl:ENSP00000398880|ensembl:ENSG00000167258(gene)|ensembl:ENST00000447079(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXK|reactome:R-HSA-6796648|dip:DIP-39768N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig.  6B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:qffna20nodTj1PmlReV/ACpVcqs9606	rigid:kUZT42Pc5FQKqbhNru4GTOj0iD8	false	sufficient binding region:1-267	sufficient binding region:696-1082(IPR011009)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:P24928-1	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-11618161	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:p24928-1(display_long)|uniprotkb:POLR2A(gene name)|psi-mi:POLR2A(display_short)|uniprotkb:POLR2(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA-directed RNA polymerase II subunit RPB1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11599017|imex:IM-25057-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	intact:EBI-295301(isoform-parent)	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig.  6B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:Si2fgh4AMaNtlzvSQhvsuPusX7s9606	rigid:kUZT42Pc5FQKqbhNru4GTOj0iD8	false	sufficient binding region:1-267	sufficient binding region:1587-1970(IPR000684)|O-phospho-L-serine:?-?|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:Q13526	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-714158|uniprotkb:Q53X75|ensembl:ENSP00000247970|ensembl:ENSP00000466962|uniprotkb:A8K4V9	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:pin1_human(display_long)|uniprotkb:Rotamase Pin1(gene name synonym)|uniprotkb:Peptidyl-prolyl cis-trans isomerase Pin1(gene name synonym)|uniprotkb:PIN1(gene name)|psi-mi:PIN1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11599017|imex:IM-25057-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	ensembl:ENSG00000127445(gene)|ensembl:ENST00000247970(transcript)|ensembl:ENST00000588695(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0016859"(cis-trans isomerase activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0050808"(synapse organization)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060393"(regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:2000146"(negative regulation of cell motility)|interpro:IPR000297(Peptidyl-prolyl cis-trans isomerase, PpiC-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR023058|interpro:IPR036020|mint:Q13526|rcsb pdb:1F8A|rcsb pdb:1I6C|rcsb pdb:1I8G|rcsb pdb:1I8H|rcsb pdb:1NMV|rcsb pdb:1NMW|rcsb pdb:1PIN|rcsb pdb:1ZCN|rcsb pdb:2F21|rcsb pdb:2ITK|rcsb pdb:2KBU|rcsb pdb:2KCF|rcsb pdb:2LB3|rcsb pdb:2M8I|rcsb pdb:2M8J|rcsb pdb:2M9E|rcsb pdb:2M9F|rcsb pdb:2M9I|rcsb pdb:2M9J|rcsb pdb:2N1O|rcsb pdb:7BDY|rcsb pdb:7BFW|rcsb pdb:7BG3|rcsb pdb:7BGQ|rcsb pdb:7BGR|rcsb pdb:7BGV|rcsb pdb:7BGW|rcsb pdb:7NIF|rcsb pdb:7NIG|rcsb pdb:7NJ6|rcsb pdb:7NJ8|rcsb pdb:7NJA|rcsb pdb:7NRK|rcsb pdb:7NRL|reactome:R-HSA-1169408|reactome:R-HSA-5668599|reactome:R-HSA-6804756|reactome:R-HSA-6811555|reactome:R-HSA-936440|rcsb pdb:2RUC|rcsb pdb:2RUD|rcsb pdb:2RUQ|rcsb pdb:2RUR|rcsb pdb:2XP3|rcsb pdb:2XP4|rcsb pdb:2XP5|rcsb pdb:2XP6|rcsb pdb:2XP7|rcsb pdb:2XP8|rcsb pdb:2XP9|rcsb pdb:2XPA|rcsb pdb:2XPB|rcsb pdb:2ZQS|rcsb pdb:2ZQT|rcsb pdb:2ZQU|rcsb pdb:2ZQV|rcsb pdb:2ZR4|rcsb pdb:2Q5A|rcsb pdb:2ZR5|rcsb pdb:2ZR6|rcsb pdb:3I6C|rcsb pdb:4TYO|rcsb pdb:4U84|rcsb pdb:4U85|rcsb pdb:4U86|rcsb pdb:5B3W|rcsb pdb:5B3X|rcsb pdb:5B3Y|rcsb pdb:5B3Z|rcsb pdb:5BMY|rcsb pdb:5GPH|rcsb pdb:5UY9|rcsb pdb:5VTI|rcsb pdb:5VTJ|rcsb pdb:5VTK|rcsb pdb:6DUN|rcsb pdb:6O33|rcsb pdb:6O34|rcsb pdb:6SVC|rcsb pdb:6SVE|rcsb pdb:6SVH|rcsb pdb:6VAJ|rcsb pdb:7AOG|rcsb pdb:7AXN|rcsb pdb:7AYF|rcsb pdb:4TNS|rcsb pdb:7AZ1|rcsb pdb:7AZ2|rcsb pdb:7BDP|rcsb pdb:7BDT|rcsb pdb:3IKD|rcsb pdb:3IKG|rcsb pdb:3JYJ|rcsb pdb:3KAB|rcsb pdb:3KAC|rcsb pdb:3KAD|rcsb pdb:3KAF|rcsb pdb:3KAG|rcsb pdb:3KAH|rcsb pdb:3KAI|rcsb pdb:3KCE|rcsb pdb:3NTP|rcsb pdb:3ODK|rcsb pdb:3OOB|rcsb pdb:3TC5|rcsb pdb:3TCZ|rcsb pdb:3TDB|rcsb pdb:3WH0|rcsb pdb:4GWT|rcsb pdb:4GWV|rcsb pdb:3IK8|rcsb pdb:4QIB|refseq:NP_006212.1|dip:DIP-29306N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig.  6B.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/04	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:FICkSpcBgvSDFW4iY1Etik85xNo9606	rigid:kUZT42Pc5FQKqbhNru4GTOj0iD8	false	sufficient binding region:1-267	his tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:47344"	uniprotkb:O75909	intact:EBI-11618406	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	psi-mi:alvocidib(display_short)|psi-mi:"CHEBI:47344"(display_long)|intact:"(-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one"(synonym)|intact:alvocidib(synonym)|intact:alvocidibum(synonym)|intact:Flavopiridol(synonym)|intact:HMR 1274(synonym)|intact:HMR-1274(synonym)|intact:L 86-8275(synonym)|intact:L 868275(synonym)|intact:L-868275(synonym)|intact:L86-8275(synonym)|intact:"2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one"(iupac name)	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11618422|imex:IM-25057-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A/B, 5A|comment:Peptide tagged with a polyethylene linker followed by two arginines.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.6x10^-5(molar)	2016/02/16	2016/03/21	-	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	-	false	-	sufficient binding region:1-267	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:47344"	uniprotkb:Q14004	intact:EBI-11618406	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	psi-mi:alvocidib(display_short)|psi-mi:"CHEBI:47344"(display_long)|intact:"(-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one"(synonym)|intact:alvocidib(synonym)|intact:alvocidibum(synonym)|intact:Flavopiridol(synonym)|intact:HMR 1274(synonym)|intact:HMR-1274(synonym)|intact:L 86-8275(synonym)|intact:L 868275(synonym)|intact:L-868275(synonym)|intact:L86-8275(synonym)|intact:"2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one"(iupac name)	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11618422|imex:IM-25057-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A/B, 5A|comment:Peptide tagged with a polyethylene linker followed by two arginines.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.6x10^-5(molar)	2016/02/16	2016/03/21	-	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	-	false	-	sufficient binding region:673-1039(IPR011009)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:47344"	intact:EBI-11618390	intact:EBI-11618406	-	psi-mi:alvocidib(display_short)|psi-mi:"CHEBI:47344"(display_long)|intact:"(-)-cis-5,7-dihydroxy-2-(2-chlorophenyl)-8-(4-(3-hydroxy-1-methyl)piperidinyl)-4H-1-benzopyran-4-one"(synonym)|intact:alvocidib(synonym)|intact:alvocidibum(synonym)|intact:Flavopiridol(synonym)|intact:HMR 1274(synonym)|intact:HMR-1274(synonym)|intact:L 86-8275(synonym)|intact:L 868275(synonym)|intact:L-868275(synonym)|intact:L86-8275(synonym)|intact:"2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydroxy-1-methylpiperidin-4-yl]-4H-chromen-4-one"(iupac name)	psi-mi:pol2ra hepta-repeat peptide(display_short)|psi-mi:EBI-11618390(display_long)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11618422|imex:IM-25057-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0327"(peptide)	-	-	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A/B, 5A|comment:Peptide tagged with a polyethylene linker followed by two arginines.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	ic50:1.6x10^-5(molar)	2016/02/16	2016/03/21	-	rogid:Yt9hKt8gdknvmPhMVcn+GjOnybA-2	-	false	-	tag:c-c|O-phospho-L-serine:7-7,14-14,21-21	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	uniprotkb:Q14004	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	intact:EBI-968626|intact:EBI-28974753|ensembl:ENSP00000181839|uniprotkb:Q6DKQ9|uniprotkb:Q75MH4|uniprotkb:Q75MH5|uniprotkb:Q96JN4|uniprotkb:Q9H4A0|uniprotkb:Q9H4A1|uniprotkb:Q9UDR4|uniprotkb:Q53G78	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:cdk13_human(display_long)|uniprotkb:CDK13(gene name)|psi-mi:CDK13(display_short)|uniprotkb:CDC2L(gene name synonym)|uniprotkb:CHED(gene name synonym)|uniprotkb:KIAA1791(gene name synonym)|uniprotkb:CDC2-related protein kinase 5(gene name synonym)|uniprotkb:Cholinesterase-related cell division controller(gene name synonym)|uniprotkb:CDC2L5(gene name synonym)|uniprotkb:Cell division cycle 2-like protein kinase 5(gene name synonym)|uniprotkb:Cell division protein kinase 13(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11660372|imex:IM-25057-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019908"(nuclear cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030332"(cyclin binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000737"(negative regulation of stem cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5EFQ|rcsb pdb:7NXJ|reactome:R-HSA-6796648|reactome:R-HSA-6798695|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000065883(gene)|ensembl:ENST00000181839(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|ensembl:ENSP00000181839|ensembl:ENST00000340829|ensembl:ENSP00000340557|refseq:NP_003709.3|refseq:NP_112557.2	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A/B, 5A-2|comment:Peptide tagged with a polyethylene linker followed by two arginines.  The enzyme showed a preference for a peptide phosphorylated at ser-21 over ser-7 but both showed reduced phosphorylation in comparison the the peptide phosphorylated on all three serines.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/21	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:kiNxSZsIO+CZ6ELhDpe1r2OooOs9606	rigid:e+T82OSEg+bERbU7ncgwN/d71LM	false	sufficient binding region:1-267	sufficient binding region:673-1039(IPR011009)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75909	intact:EBI-11618390	intact:EBI-739806|uniprotkb:Q96B63|uniprotkb:Q9NNY9|uniprotkb:Q59FT6|uniprotkb:Q86U16|ensembl:ENSP00000374529	-	psi-mi:ccnk_human(display_long)|uniprotkb:CCNK(gene name)|psi-mi:CCNK(display_short)|uniprotkb:CPR4(gene name synonym)	psi-mi:pol2ra hepta-repeat peptide(display_short)|psi-mi:EBI-11618390(display_long)	psi-mi:"MI:0424"(protein kinase assay)	Greifenberg et al. (2016)	imex:IM-25057|pubmed:26748711	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11660372|imex:IM-25057-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_001092872.1|ensembl:ENSG00000090061(gene)|ensembl:ENST00000389879(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0002944"(cyclin K-CDK12 complex)|go:"GO:0002945"(cyclin K-CDK13 complex)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0008024"(cyclin/CDK positive transcription elongation factor complex)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:2001165"(positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR043198|rcsb pdb:2I53|rcsb pdb:4CXA|rcsb pdb:4NST|rcsb pdb:4UN0|rcsb pdb:5ACB|rcsb pdb:5EFQ|rcsb pdb:6B3E|rcsb pdb:6CKX|rcsb pdb:6TD3|rcsb pdb:7NXJ|rcsb pdb:7NXK|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-2173796|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955|refseq:XP_005268211.1|refseq:XP_011535577.1|dip:DIP-50081N	-	go:"GO:0004672"(protein kinase activity)	-	-	figure legend:Fig. 4A/B, 5A-2|comment:Peptide tagged with a polyethylene linker followed by two arginines.  The enzyme showed a preference for a peptide phosphorylated at ser-21 over ser-7 but both showed reduced phosphorylation in comparison the the peptide phosphorylated on all three serines.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/02/16	2016/03/21	rogid:GwKOLtYbHmvvuRXSwfW4pffSDpE9606	rogid:Yt9hKt8gdknvmPhMVcn+GjOnybA-2	rigid:e+T82OSEg+bERbU7ncgwN/d71LM	false	sufficient binding region:1-267	tag:c-c|O-phospho-L-serine:7-7,14-14,21-21	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)