#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:B1PVV8 uniprotkb:Q04967 intact:EBI-12556408 intact:EBI-12556695 psi-mi:b1pvv8_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym) psi-mi:hsp76_pig(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2015) pubmed:25827528|imex:IM-26058 taxid:11096(classical swine fever virus)|taxid:11096(Classical swine fever virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12556693|imex:IM-26058-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022120|interpro:IPR030399|interpro:IPR027417|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR032521|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR033130|interpro:IPR042542|interpro:IPR036430|interpro:IPR043502|interpro:IPR043128 go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|refseq:NP_001116599.1|interpro:IPR018181|interpro:IPR029048|interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129 - - - figure legend:1A and 2|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-suvec)|taxid:9823(pig umbilical vein endothelial cell line) - 2016/10/07 2016/10/07 rogid:WcAEw6JC6WsAkhGnW7DieP2d6mA11096 rogid:ibT7yB5szvbGW10uEJBVc2xt1Nw9823 rigid:M+HJDFtRX19kvpgeWLK+hsU/INg false flag tag:c-c|sufficient binding region:2713..2713-2925..2925|binding-associated region:2684..2684-3180..3180 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:B1PVV8 uniprotkb:Q04967 intact:EBI-12556408 intact:EBI-12556695 psi-mi:b1pvv8_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym) psi-mi:hsp76_pig(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2015) pubmed:25827528|imex:IM-26058 taxid:11096(classical swine fever virus)|taxid:11096(Classical swine fever virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12556721|imex:IM-26058-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022120|interpro:IPR030399|interpro:IPR027417|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR032521|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR033130|interpro:IPR042542|interpro:IPR036430|interpro:IPR043502|interpro:IPR043128 go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|refseq:NP_001116599.1|interpro:IPR018181|interpro:IPR029048|interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129 - - - figure legend:1B|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-suvec)|taxid:9823(pig umbilical vein endothelial cell line) - 2016/10/07 2016/10/07 rogid:WcAEw6JC6WsAkhGnW7DieP2d6mA11096 rogid:ibT7yB5szvbGW10uEJBVc2xt1Nw9823 rigid:M+HJDFtRX19kvpgeWLK+hsU/INg false flag tag:c-c|binding-associated region:2684..2684-3180..3180 myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B1PVV8 uniprotkb:Q04967 intact:EBI-12556408 intact:EBI-12556695 psi-mi:b1pvv8_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym) psi-mi:hsp76_pig(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Zhang et al. (2015) pubmed:25827528|imex:IM-26058 taxid:11096(classical swine fever virus)|taxid:11096(Classical swine fever virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12556734|imex:IM-26058-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022120|interpro:IPR030399|interpro:IPR027417|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR032521|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR033130|interpro:IPR042542|interpro:IPR036430|interpro:IPR043502|interpro:IPR043128 go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|refseq:NP_001116599.1|interpro:IPR018181|interpro:IPR029048|interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129 - - - figure legend:1C|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-suvec)|taxid:9823(pig umbilical vein endothelial cell line) - 2016/10/07 2016/10/19 rogid:WcAEw6JC6WsAkhGnW7DieP2d6mA11096 rogid:ibT7yB5szvbGW10uEJBVc2xt1Nw9823 rigid:M+HJDFtRX19kvpgeWLK+hsU/INg false flag tag:c-c|binding-associated region:2684..2684-3180..3180 myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B1PVV8 uniprotkb:Q04967 intact:EBI-12556408 intact:EBI-12556695 psi-mi:b1pvv8_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym) psi-mi:hsp76_pig(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0096"(pull down) Zhang et al. (2015) pubmed:25827528|imex:IM-26058 taxid:11096(classical swine fever virus)|taxid:11096(Classical swine fever virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-12556761|imex:IM-26058-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022120|interpro:IPR030399|interpro:IPR027417|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR032521|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR033130|interpro:IPR042542|interpro:IPR036430|interpro:IPR043502|interpro:IPR043128 go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|refseq:NP_001116599.1|interpro:IPR018181|interpro:IPR029048|interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129 - - - figure legend:1D|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/10/07 2016/10/07 rogid:WcAEw6JC6WsAkhGnW7DieP2d6mA11096 rogid:ibT7yB5szvbGW10uEJBVc2xt1Nw9823 rigid:M+HJDFtRX19kvpgeWLK+hsU/INg false flag tag:c-c|binding-associated region:2684..2684-3180..3180 glutathione s tranferase tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:B1PVV8 uniprotkb:Q04967 intact:EBI-12556408 intact:EBI-12556695 psi-mi:b1pvv8_9flav(display_long)|uniprotkb:Capsid protein C(gene name synonym)|uniprotkb:Cysteine protease NS2(gene name synonym)|uniprotkb:"E(rns) glycoprotein"(gene name synonym)|uniprotkb:Envelope glycoprotein E1(gene name synonym)|uniprotkb:Envelope glycoprotein E2(gene name synonym)|uniprotkb:Genome polyprotein(gene name synonym)|uniprotkb:N-terminal protease(gene name synonym)|uniprotkb:NS5B(gene name synonym)|uniprotkb:Non-structural protein 2(gene name synonym)|uniprotkb:Non-structural protein 2-3(gene name synonym)|uniprotkb:Non-structural protein 3(gene name synonym)|uniprotkb:Non-structural protein 4A(gene name synonym)|uniprotkb:Non-structural protein 4B(gene name synonym)|uniprotkb:Non-structural protein 5A(gene name synonym)|uniprotkb:RNA-directed RNA polymerase(gene name synonym)|uniprotkb:Serine protease NS3(gene name synonym)|uniprotkb:gp33(gene name synonym)|uniprotkb:gp44/48(gene name synonym)|uniprotkb:gp55(gene name synonym)|uniprotkb:Viroporin p7(gene name synonym) psi-mi:hsp76_pig(display_long)|uniprotkb:HSPA6(gene name)|psi-mi:HSPA6(display_short)|uniprotkb:HSP70B'(gene name synonym)|uniprotkb:Heat shock 70 kDa protein B'(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Zhang et al. (2015) pubmed:25827528|imex:IM-26058 taxid:11096(classical swine fever virus)|taxid:11096(Classical swine fever virus) taxid:9823(pig)|taxid:9823("Sus scrofa (Pig)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1335"(HPIDb) intact:EBI-12556779|imex:IM-26058-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019082"(viral protein processing)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0033897"(ribonuclease T2 activity)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0044228"(host cell surface)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0055036"(virion membrane)|go:"GO:0070008"(serine-type exopeptidase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR042309|interpro:IPR042310|interpro:IPR042311|interpro:IPR021824|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR022120|interpro:IPR030399|interpro:IPR027417|interpro:IPR008751(Peptidase C53, pestivirus Npro)|interpro:IPR032521|interpro:IPR000280(Peptidase S31, pestivurus polyprotein NS3/p80)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002166(RNA dependent RNA polymerase, hepatitis C virus)|interpro:IPR033130|interpro:IPR042542|interpro:IPR036430|interpro:IPR043502|interpro:IPR043128 go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|refseq:NP_001116599.1|interpro:IPR018181|interpro:IPR029048|interpro:IPR029047|interpro:IPR013126(Heat shock protein 70)|interpro:IPR043129 go:"GO:0005783"(endoplasmic reticulum) - - figure legend:3|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9823(pig-suvec)|taxid:9823(pig umbilical vein endothelial cell line) - 2016/10/07 2016/10/07 rogid:WcAEw6JC6WsAkhGnW7DieP2d6mA11096 rogid:ibT7yB5szvbGW10uEJBVc2xt1Nw9823 rigid:M+HJDFtRX19kvpgeWLK+hsU/INg false green fluorescent protein tag:c-c|binding-associated region:2684..2684-3180..3180 red fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence)