#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P18828 uniprotkb:Q15113 intact:EBI-9985816|ensembl:ENSMUSP00000020911|ensembl:ENSMUSP00000131491|uniprotkb:Q62278|uniprotkb:Q9WVD2 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc1_mouse(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd-1(gene name synonym)|uniprotkb:Synd1(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11575784 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020592(gene)|ensembl:ENSMUST00000171158(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-449836|reactome:R-MMU-975634|ensembl:ENSMUST00000020911(transcript)|refseq:NP_035649.1 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:FiG 1A|comment:PCPE-Flag binding to syndecan-1 was completely blocked upon removal of the GAG chains by heparitinase I indicating that the GAG chains are required for binding.|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/05/11 rogid:bjqVkyATkn4Ir7AqWd02m/YLOp410090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:zu3VNFchKDT6+deBwnUlueck9nk false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P43407 uniprotkb:Q15113 intact:EBI-11578890|ensembl:ENSMUSP00000022871 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc2_mouse(display_long)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11578918 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032330.1|ensembl:ENSMUSG00000022261(gene)|ensembl:ENSMUST00000022871(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-381426|reactome:R-MMU-3928662|reactome:R-MMU-8957275|reactome:R-MMU-975634|reactome:R-MMU-3000170 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:FiG. 2B|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:xwEF8FBoPGR6W1dq7wa+GMYmRb010090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:bLtFe8pp9EoAKTU1K2XRRm/SR/o false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c|sufficient binding region:318-437(IPR001134) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O35988 uniprotkb:Q15113 intact:EBI-9986850|ensembl:ENSMUSP00000017153 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc4_mouse(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11578925 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:0045121"(membrane raft)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|reactome:R-MMU-1971475|go:"GO:0045860"(positive regulation of protein kinase activity)|reactome:R-MMU-2022928|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-975634|ensembl:ENSMUSG00000017009(gene)|ensembl:ENSMUST00000017153(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|refseq:NP_035651.1 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - comment:PCPE-Flag binding to syndecan-4 was greatly reduced upon removal of the GAG chains by heparitinse I and chondroitinase ABC indicating that the GAG chains are required for binding. - figure legend:FIG. 1B|comment:PCPE-Flag binding to syndecan-4 was greatly reduced upon removal of the GAG chains by heparitinase I and chondroitinase ABC indicating that the GAG chains are required for binding.|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/05/11 rogid:O8ZQM+ystmX927MWsVaoV51rH2w10090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:4YAjylnXFa1SpGBp6ekYzxzscfc false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15113 uniprotkb:P18828 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 intact:EBI-9985816|ensembl:ENSMUSP00000020911|ensembl:ENSMUSP00000131491|uniprotkb:Q62278|uniprotkb:Q9WVD2 psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:sdc1_mouse(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd-1(gene name synonym)|uniprotkb:Synd1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660343 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 ensembl:ENSMUSG00000020592(gene)|ensembl:ENSMUST00000171158(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-449836|reactome:R-MMU-975634|ensembl:ENSMUST00000020911(transcript)|refseq:NP_035649.1 - - - figure legend:Figure 1C|comment:"Glycosidase treatment (heparitinase I + chondroitinase ABC) was required for syndecan-1 detection"|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rogid:bjqVkyATkn4Ir7AqWd02m/YLOp410090 rigid:zu3VNFchKDT6+deBwnUlueck9nk false flag tag:c-c heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q15113 uniprotkb:O35988 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 intact:EBI-9986850|ensembl:ENSMUSP00000017153 psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:sdc4_mouse(display_long)|uniprotkb:Sdc4(gene name)|psi-mi:Sdc4(display_short)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660367 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|go:"GO:0045121"(membrane raft)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|reactome:R-MMU-1971475|go:"GO:0045860"(positive regulation of protein kinase activity)|reactome:R-MMU-2022928|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-975634|ensembl:ENSMUSG00000017009(gene)|ensembl:ENSMUST00000017153(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|refseq:NP_035651.1 - - - comment:"Glycosidase treatment (heparitinase I + chondroitinase ABC) was required to release the core protein of syndecan-4 for detection"|figure legend:Figure 1D|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rogid:O8ZQM+ystmX927MWsVaoV51rH2w10090 rigid:4YAjylnXFa1SpGBp6ekYzxzscfc false flag tag:c-c heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P43407 uniprotkb:Q15113 intact:EBI-11578890|ensembl:ENSMUSP00000022871 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc2_mouse(display_long)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660491 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032330.1|ensembl:ENSMUSG00000022261(gene)|ensembl:ENSMUST00000022871(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-381426|reactome:R-MMU-3928662|reactome:R-MMU-8957275|reactome:R-MMU-975634|reactome:R-MMU-3000170 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 2A|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:xwEF8FBoPGR6W1dq7wa+GMYmRb010090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:bLtFe8pp9EoAKTU1K2XRRm/SR/o false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P18827 uniprotkb:Q16787 intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542 intact:EBI-725611|uniprotkb:Q6VU68|uniprotkb:Q76E14|uniprotkb:Q13679|uniprotkb:Q13680|uniprotkb:Q96TG0|intact:EBI-1048456|intact:EBI-2321902|uniprotkb:Q6VU67|uniprotkb:Q6VU69|ensembl:ENSP00000324532|uniprotkb:B0YJ33 psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym) psi-mi:lama3_human(display_long)|uniprotkb:Epiligrin 170 kDa subunit(gene name synonym)|uniprotkb:Nicein subunit alpha(gene name synonym)|uniprotkb:LAMA3(gene name)|psi-mi:LAMA3(display_short)|uniprotkb:LAMNA(gene name synonym)|uniprotkb:Laminin-5 subunit alpha(gene name synonym)|uniprotkb:Laminin-6 subunit alpha(gene name synonym)|uniprotkb:Laminin-7 subunit alpha(gene name synonym)|uniprotkb:Kalinin subunit alpha(gene name synonym)|uniprotkb:Epiligrin subunit alpha(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660507 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide) refseq:NP_000218.3|refseq:NP_001121189.2|refseq:NP_001121190.2|refseq:NP_001289925.1|refseq:NP_937762.2|ensembl:ENSG00000053747(gene)|ensembl:ENST00000313654(transcript)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005178"(integrin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005610"(laminin-5 complex)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008544"(epidermis development)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001791(Laminin G)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR009254(Laminin I)|interpro:IPR010307(Laminin II)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|reactome:R-HSA-1474228|reactome:R-HSA-2022090|reactome:R-HSA-2214320|reactome:R-HSA-3000157|reactome:R-HSA-3000171|reactome:R-HSA-3000178|reactome:R-HSA-446107|reactome:R-HSA-8874081 - - - figure legend:Figure 1E lane 3|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606 rogid:M41VuGWJkIfd8M/obG+cELCe0PU9606 rigid:O0P9+4Ghd4qVfQ56dEw4bIaFF1E false flag tag:?-? sufficient binding region:2974-3333 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P18828 uniprotkb:Q15113 intact:EBI-9985816|ensembl:ENSMUSP00000020911|ensembl:ENSMUSP00000131491|uniprotkb:Q62278|uniprotkb:Q9WVD2 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc1_mouse(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd-1(gene name synonym)|uniprotkb:Synd1(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660759 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020592(gene)|ensembl:ENSMUST00000171158(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-449836|reactome:R-MMU-975634|ensembl:ENSMUST00000020911(transcript)|refseq:NP_035649.1 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 3A|comment:The NTR domain strongly inhibited binding of PCPE-1 to syndecan-1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:bjqVkyATkn4Ir7AqWd02m/YLOp410090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:zu3VNFchKDT6+deBwnUlueck9nk false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P18828 uniprotkb:Q15113 intact:EBI-9985816|ensembl:ENSMUSP00000020911|ensembl:ENSMUSP00000131491|uniprotkb:Q62278|uniprotkb:Q9WVD2 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc1_mouse(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd-1(gene name synonym)|uniprotkb:Synd1(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660759 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020592(gene)|ensembl:ENSMUST00000171158(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-449836|reactome:R-MMU-975634|ensembl:ENSMUST00000020911(transcript)|refseq:NP_035649.1 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 3A|comment:The NTR domain strongly inhibited binding of PCPE-1 to syndecan-1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:bjqVkyATkn4Ir7AqWd02m/YLOp410090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:zu3VNFchKDT6+deBwnUlueck9nk false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? sufficient binding region:318-437|flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) chebi:"CHEBI:28304" uniprotkb:P18828 intact:EBI-1379423 intact:EBI-9985816|ensembl:ENSMUSP00000020911|ensembl:ENSMUSP00000131491|uniprotkb:Q62278|uniprotkb:Q9WVD2 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:sdc1_mouse(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd-1(gene name synonym)|uniprotkb:Synd1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660813 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - ensembl:ENSMUSG00000020592(gene)|ensembl:ENSMUST00000171158(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-449836|reactome:R-MMU-975634|ensembl:ENSMUST00000020911(transcript)|refseq:NP_035649.1 - - - figure legend:Figure 3B|comment:Heparin fully inhibits the interaction of PCPE-Flag with syndecan-1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 - rogid:bjqVkyATkn4Ir7AqWd02m/YLOp410090 - false - heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P18828 uniprotkb:Q15113 intact:EBI-9985816|ensembl:ENSMUSP00000020911|ensembl:ENSMUSP00000131491|uniprotkb:Q62278|uniprotkb:Q9WVD2 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc1_mouse(display_long)|uniprotkb:Sdc1(gene name)|psi-mi:Sdc1(display_short)|uniprotkb:Synd-1(gene name synonym)|uniprotkb:Synd1(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660813 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020592(gene)|ensembl:ENSMUST00000171158(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005576"(extracellular region)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-449836|reactome:R-MMU-975634|ensembl:ENSMUST00000020911(transcript)|refseq:NP_035649.1 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 3B|comment:Heparin fully inhibits the interaction of PCPE-Flag with syndecan-1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:bjqVkyATkn4Ir7AqWd02m/YLOp410090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 - false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-?|chondroitin sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) chebi:"CHEBI:28304" uniprotkb:P43407 intact:EBI-1379423 intact:EBI-11578890|ensembl:ENSMUSP00000022871 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:sdc2_mouse(display_long)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660830 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_032330.1|ensembl:ENSMUSG00000022261(gene)|ensembl:ENSMUST00000022871(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-381426|reactome:R-MMU-3928662|reactome:R-MMU-8957275|reactome:R-MMU-975634|reactome:R-MMU-3000170 - - - comment:Heparin inhibits PCPE-Flag binding to syndecan-2.|figure legend:Figure 3C|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 - rogid:xwEF8FBoPGR6W1dq7wa+GMYmRb010090 - false - heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P43407 uniprotkb:Q15113 intact:EBI-11578890|ensembl:ENSMUSP00000022871 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc2_mouse(display_long)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660830 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032330.1|ensembl:ENSMUSG00000022261(gene)|ensembl:ENSMUST00000022871(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-381426|reactome:R-MMU-3928662|reactome:R-MMU-8957275|reactome:R-MMU-975634|reactome:R-MMU-3000170 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - comment:Heparin inhibits PCPE-Flag binding to syndecan-2.|figure legend:Figure 3C|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:xwEF8FBoPGR6W1dq7wa+GMYmRb010090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 - false heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:?-? flag tag:c-c - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P18827 uniprotkb:Q15113 intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11666864 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide) refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 1E lane 2|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:wewVIDPpwpUMrxSj8GLtw68tJdM false - - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:P43407 uniprotkb:Q15113 intact:EBI-11578890|ensembl:ENSMUSP00000022871 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:sdc2_mouse(display_long)|uniprotkb:Fibroglycan(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan core protein(gene name synonym)|uniprotkb:Sdc2(gene name)|psi-mi:Sdc2(display_short)|uniprotkb:Hspg1(gene name synonym)|uniprotkb:Synd2(gene name synonym) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Weiss et al. (2014) pubmed:25286301 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660535 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_032330.1|ensembl:ENSMUSG00000022261(gene)|ensembl:ENSMUST00000022871(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031201|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-381426|reactome:R-MMU-3928662|reactome:R-MMU-8957275|reactome:R-MMU-975634|reactome:R-MMU-3000170 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 2C|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:xwEF8FBoPGR6W1dq7wa+GMYmRb010090 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:bLtFe8pp9EoAKTU1K2XRRm/SR/o false - flag tag:c-c - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P07589 uniprotkb:Q15113 intact:EBI-11147184 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:finc_bovin(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Weiss et al. (2014) pubmed:25286301 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660847 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000083(Fibronectin, type I)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR036116|interpro:IPR036943 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure4A, 4B|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/21 rogid:4pt20MEf9GMmrbrp/Yxv1UJIaBs9913 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:d+EMnv6fBixvBYwtPS+bWuAgDe8 false - flag tag:c-c|sufficient binding region:318-437 - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P07589 uniprotkb:Q15113 intact:EBI-11147184 intact:EBI-8869614|uniprotkb:B2R9E1|uniprotkb:O14550|ensembl:ENSP00000223061 psi-mi:finc_bovin(display_long)|uniprotkb:FN1(gene name)|psi-mi:FN1(display_short) psi-mi:pcoc1_human(display_long)|uniprotkb:PCOLCE(gene name)|psi-mi:PCOLCE(display_short)|uniprotkb:PCPE1(gene name synonym)|uniprotkb:Procollagen COOH-terminal proteinase enhancer 1(gene name synonym)|uniprotkb:Type 1 procollagen C-proteinase enhancer protein(gene name synonym)|uniprotkb:Type I procollagen COOH-terminal proteinase enhancer(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Weiss et al. (2014) pubmed:25286301 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-11660865 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR000083(Fibronectin, type I)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|go:"GO:0001525"(angiogenesis)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070527"(platelet aggregation)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR036116|interpro:IPR036943 refseq:NP_002584.2|ensembl:ENSG00000106333(gene)|ensembl:ENST00000223061(transcript)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008201"(heparin binding)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000859(CUB)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR018933|interpro:IPR028870|interpro:IPR035814|interpro:IPR035914|rcsb pdb:1UAP|rcsb pdb:6FZV|rcsb pdb:6FZW|reactome:R-HSA-1650814|reactome:R-HSA-2243919 - - - figure legend:Figure 4C|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/02/11 2016/03/25 rogid:4pt20MEf9GMmrbrp/Yxv1UJIaBs9913 rogid:BbtXSWAh1THRHXXSV89MMdFMgeg9606 rigid:d+EMnv6fBixvBYwtPS+bWuAgDe8 false - flag tag:c-c|sufficient binding region:318-437 - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)