#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B chebi:"CHEBI:16336" uniprotkb:P98066 intact:EBI-2566617 intact:EBI-11700693|uniprotkb:Q53TI7|uniprotkb:Q8WWI9|ensembl:ENSP00000243347 psi-mi:hyaluronan(display_short)|psi-mi:"CHEBI:16336"(display_long) psi-mi:tsg6_human(display_long)|uniprotkb:TSG6(gene name synonym)|uniprotkb:TNFAIP6(gene name)|psi-mi:TNFAIP6(display_short)|uniprotkb:Hyaluronate-binding protein(gene name synonym)|uniprotkb:TNF-stimulated gene 6 protein(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 6(gene name synonym) psi-mi:"MI:0892"(solid phase assay) Baranova et al. (2013) pubmed:24005673|imex:IM-25293 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11710306|imex:IM-25293-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_9(source reference) refseq:NP_009046.2|ensembl:ENSG00000123610(gene)|ensembl:ENST00000243347(transcript)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030728"(ovulation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000538(Link)|interpro:IPR000859(CUB)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR035914|rcsb pdb:1O7B|rcsb pdb:1O7C|rcsb pdb:2N40|rcsb pdb:2PF5|rcsb pdb:2WNO|reactome:R-HSA-6798695 - - - figure legend:1, 4|comment:"The addition of Inter-alpha-trypsin inhibitor (exact composition unknown) from human serum initially inhibited this reaction."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/05/11 2016/06/01 - rogid:2Ea1tHjyixlxoJd7hef0CyUkjgk9606 - false biotin tag:?-? - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19827-PRO_0000016507 uniprotkb:P98066 intact:EBI-11710335 intact:EBI-11700693|uniprotkb:Q53TI7|uniprotkb:Q8WWI9|ensembl:ENSP00000243347 psi-mi:p19827-pro_0000016507(display_long)|uniprotkb:ITIH1(gene name)|psi-mi:ITIH1(display_short)|uniprotkb:IGHEP1(gene name synonym)|uniprotkb:Inter-alpha-trypsin inhibitor complex component III(gene name synonym)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym) psi-mi:tsg6_human(display_long)|uniprotkb:TSG6(gene name synonym)|uniprotkb:TNFAIP6(gene name)|psi-mi:TNFAIP6(display_short)|uniprotkb:Hyaluronate-binding protein(gene name synonym)|uniprotkb:TNF-stimulated gene 6 protein(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Baranova et al. (2013) pubmed:24005673|imex:IM-25293 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11710329|imex:IM-25293-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-1223859(chain-parent) refseq:NP_009046.2|ensembl:ENSG00000123610(gene)|ensembl:ENST00000243347(transcript)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030728"(ovulation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000538(Link)|interpro:IPR000859(CUB)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR035914|rcsb pdb:1O7B|rcsb pdb:1O7C|rcsb pdb:2N40|rcsb pdb:2PF5|rcsb pdb:2WNO|reactome:R-HSA-6798695 - chain-seq-start:35|chain-seq-end:672 - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.3x10^-9(molar) 2016/05/11 2016/06/01 rogid:FWZ22YtrXRI4ZtPMnWNdA6fe0OQ9606 rogid:2Ea1tHjyixlxoJd7hef0CyUkjgk9606 rigid:DNNamL3R8B45gkN1XUjp0GQP24g false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P19823-PRO_0000016518 uniprotkb:P98066 intact:EBI-11710349 intact:EBI-11700693|uniprotkb:Q53TI7|uniprotkb:Q8WWI9|ensembl:ENSP00000243347 psi-mi:p19823-pro_0000016518(display_long)|uniprotkb:ITIH2(gene name)|psi-mi:ITIH2(display_short)|uniprotkb:IGHEP2(gene name synonym)|uniprotkb:Inter-alpha-trypsin inhibitor complex component II(gene name synonym)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym) psi-mi:tsg6_human(display_long)|uniprotkb:TSG6(gene name synonym)|uniprotkb:TNFAIP6(gene name)|psi-mi:TNFAIP6(display_short)|uniprotkb:Hyaluronate-binding protein(gene name synonym)|uniprotkb:TNF-stimulated gene 6 protein(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Baranova et al. (2013) pubmed:24005673|imex:IM-25293 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11710342|imex:IM-25293-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-718353(chain-parent) refseq:NP_009046.2|ensembl:ENSG00000123610(gene)|ensembl:ENST00000243347(transcript)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030728"(ovulation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000538(Link)|interpro:IPR000859(CUB)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR035914|rcsb pdb:1O7B|rcsb pdb:1O7C|rcsb pdb:2N40|rcsb pdb:2PF5|rcsb pdb:2WNO|reactome:R-HSA-6798695 - chain-seq-start:55|chain-seq-end:702 - figure legend:2-2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.5x10^-9(molar) 2016/05/11 2016/06/01 rogid:wPrzoMOy93zSM95wxAWggN48L5o9606 rogid:2Ea1tHjyixlxoJd7hef0CyUkjgk9606 rigid:MrOxiBZt6COgQLZuSEv2gG6cOKI false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q06033-PRO_0000016530 uniprotkb:P98066 intact:EBI-11710362 intact:EBI-11700693|uniprotkb:Q53TI7|uniprotkb:Q8WWI9|ensembl:ENSP00000243347 psi-mi:q06033-pro_0000016530(display_long)|uniprotkb:ITIH3(gene name)|psi-mi:ITIH3(display_short)|uniprotkb:Serum-derived hyaluronan-associated protein(gene name synonym) psi-mi:tsg6_human(display_long)|uniprotkb:TSG6(gene name synonym)|uniprotkb:TNFAIP6(gene name)|psi-mi:TNFAIP6(display_short)|uniprotkb:Hyaluronate-binding protein(gene name synonym)|uniprotkb:TNF-stimulated gene 6 protein(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 6(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Baranova et al. (2013) pubmed:24005673|imex:IM-25293 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11710355|imex:IM-25293-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-3929079(chain-parent) refseq:NP_009046.2|ensembl:ENSG00000123610(gene)|ensembl:ENST00000243347(transcript)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030728"(ovulation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000538(Link)|interpro:IPR000859(CUB)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR035914|rcsb pdb:1O7B|rcsb pdb:1O7C|rcsb pdb:2N40|rcsb pdb:2PF5|rcsb pdb:2WNO|reactome:R-HSA-6798695 - chain-seq-start:35|chain-seq-end:651 - figure legend:2-3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) kd:6.5x10^-9(molar) 2016/05/11 2016/06/01 rogid:P1GmR8M2Jm8FRB540GP+J8XAvXE9606 rogid:2Ea1tHjyixlxoJd7hef0CyUkjgk9606 rigid:O6TqnHf+SYpkVE0Q6H/cGbat0lk false his tag:n-n - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)