#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P07550	uniprotkb:Q96B67	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11673201|imex:IM-25078-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	-	-	-	figure legend:2A|agonist:"CHEBI:64317:isoproterenol (Isoprenaline) - a non-selective beta-adrenoreceptor agonist that is structurally similar to  adrenaline."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/30	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:1RxAR2NSef42vP0gn5Tvt2Hrvpc	false	ha tag:n-n	mcherry fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P46934	uniprotkb:Q96B67	intact:EBI-726944|ensembl:ENSP00000424827|uniprotkb:A1KY35|uniprotkb:A6ND72|uniprotkb:A7MD29|uniprotkb:B4E2R7|uniprotkb:B7ZM59|uniprotkb:B7ZM60|uniprotkb:B9EGN5|uniprotkb:D6RF89|intact:EBI-28969445	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:nedd4_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:NEDD4(gene name)|psi-mi:NEDD4(display_short)|uniprotkb:KIAA0093(gene name synonym)|uniprotkb:NEDD4-1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 53 protein(gene name synonym)|uniprotkb:PIG53(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682216|imex:IM-25078-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001271267.1|refseq:NP_001271268.1|refseq:NP_001271269.1|ensembl:ENSG00000069869(gene)|ensembl:ENST00000508342(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010768"(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043197"(dendritic spine)|go:"GO:0044111"(formation of structure involved in a symbiotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046755"(viral budding)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46934|rcsb pdb:2KPZ|rcsb pdb:2KQ0|go:"GO:0050815"(phosphoserine residue binding)|rcsb pdb:2M3O|rcsb pdb:2XBB|rcsb pdb:2XBF|rcsb pdb:3B7Y|rcsb pdb:4BBN|rcsb pdb:4BE8|rcsb pdb:4N7F|rcsb pdb:4N7H|rcsb pdb:5AHT|rcsb pdb:5C7J|rcsb pdb:5C91|reactome:R-HSA-1169408|reactome:R-HSA-1253288|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-983168|refseq:NP_006145.2|refseq:NP_940682.2|ensembl:ENST00000338963|ensembl:ENSP00000345530|ensembl:ENST00000435532|ensembl:ENSP00000410613|ensembl:ENST00000506154|ensembl:ENSP00000422705|ensembl:ENSP00000424827|refseq:NP_001316141.1|dip:DIP-29815N	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	go:"GO:0031410"(cytoplasmic vesicle)	-	-	figure legend:4B|agonist:"CHEBI:64317:isoproterenol (Isoprenaline) - a non-selective beta-adrenoreceptor agonist that is structurally similar to  adrenaline."|comment:"It is not clear if NEDD4 has a GFP or a myc (N-terminal) tag."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:R0IvurHHFLE8EYZK1hRLsSwbs5I9606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:/vN9sO9SQY6/uZUYXShYpakTpMM	false	tag:?-?	mcherry fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P07550	uniprotkb:Q96B67	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11674311|imex:IM-25078-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	-	-	-	figure legend:2B|agonist:"CHEBI:64317:isoproterenol (Isoprenaline) - a non-selective beta-adrenoreceptor agonist that is structurally similar to  adrenaline."|comment:"Clathrin (heavy chains) and  HGS were also detected but have not been  annotated  as specific interactors because  they were also immunoprecipitated by the empty vector."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/30	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:1RxAR2NSef42vP0gn5Tvt2Hrvpc	false	ha tag:n-n	green fluorescent protein tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30518	uniprotkb:Q8NCT1	intact:EBI-11675746|uniprotkb:C5HF20|uniprotkb:O43192|uniprotkb:Q3MJD3|uniprotkb:Q9UCV9|ensembl:ENSP00000338072|ensembl:ENSP00000496396	intact:EBI-11673273|uniprotkb:Q6NSI9|intact:EBI-28978776|ensembl:ENSP00000268042	psi-mi:v2r_human(display_long)|uniprotkb:AVPR V2(gene name synonym)|uniprotkb:Antidiuretic hormone receptor(gene name synonym)|uniprotkb:Renal-type arginine vasopressin receptor(gene name synonym)|uniprotkb:AVPR2(gene name)|psi-mi:AVPR2(display_short)|uniprotkb:ADHR(gene name synonym)|uniprotkb:DIR(gene name synonym)|uniprotkb:DIR3(gene name synonym)|uniprotkb:V2R(gene name synonym)	psi-mi:arrd4_human(display_long)|uniprotkb:ARRDC4(gene name)|psi-mi:ARRDC4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11675497|imex:IM-25078-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000045.1|refseq:NP_001139623.1|refseq:XP_006724891.1|ensembl:ENST00000337474(transcript)|ensembl:ENST00000646375(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENSG00000126895(gene)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007588"(excretion)|go:"GO:0007599"(hemostasis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0034097"(response to cytokine)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000161(Vasopressin V2 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4JQI|rcsb pdb:6NI2|rcsb pdb:6U1N|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7KH0|reactome:R-HSA-388479|reactome:R-HSA-418555|reactome:R-HSA-432040|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9036092|reactome:R-HSA-9660821	ensembl:ENSP00000268042|refseq:NP_899232.2|ensembl:ENSG00000140450(gene)|ensembl:ENST00000268042(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	-	-	-	figure legend:2C|comment:"Clathrin (heavy chains) and  HGS were also detected but have not been  annotated  as specific interactors because  they were also immunoprecipitated with  the empty vector."|agonist:"AVP-Arginine-vasopressin -UniProt ID:PRO_0000020515"|comment:"The ARRDC4 tag has been entered as \"mcherry\" despite the fact the image text refers to pcDNA3-\"ARRDC4-FLAG\"; figure 3 specifically mentions that an mcherry tag was used in figure 2C."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/30	rogid:zjK7PcQaMOPOsDBE0WhsVpAi4nA9606	rogid:LefCyMgfWvQUaEez5JFZLOHO8tg9606	rigid:dQFduu7iv801o5N4XWrFNI0G62U	false	ha tag:n-n|v5 tag:c-c	mcherry fluorescent protein tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B67	uniprotkb:O00308	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682257|imex:IM-25078-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:4C|comment:PY motif mutagenesis revealed that aArr-E3 interactions were PY-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:OODjcTSQ9erpYUfnvETHkXmLZiI	false	flag tag:c-c|mutation disrupting interaction strength:347-347,349-349,392-392,394-394	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B67	uniprotkb:Q96PU5	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	intact:EBI-717962|uniprotkb:O43165|uniprotkb:Q7Z5F1|uniprotkb:Q7Z5F2|uniprotkb:Q7Z5N3|uniprotkb:Q8N5A7|uniprotkb:Q8WUU9|uniprotkb:Q9BW58|uniprotkb:Q9H2W4|uniprotkb:Q9NT88|uniprotkb:Q3LSM7|intact:EBI-28979180|ensembl:ENSP00000383199	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:ned4l_human(display_long)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:NEDD4L(gene name)|psi-mi:NEDD4L(display_short)|uniprotkb:KIAA0439(gene name synonym)|uniprotkb:NEDL3(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682257|imex:IM-25078-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	refseq:NP_001138436.1|refseq:NP_001138437.1|refseq:NP_001138438.1|refseq:NP_001138439.1|refseq:NP_001138440.1|refseq:NP_001138441.1|refseq:NP_001138442.1|refseq:NP_056092.2|refseq:NP_001230889.1|ensembl:ENSP00000383199|ensembl:ENSP00000372301|ensembl:ENST00000431212|ensembl:ENSP00000389406|ensembl:ENST00000435432|ensembl:ENSP00000393395|ensembl:ENST00000456173|ensembl:ENSP00000405440|ensembl:ENST00000456986|ensembl:ENSP00000411947|ensembl:ENST00000586263|ensembl:ENSP00000468546|ensembl:ENST00000674517|ensembl:ENSP00000501665|ensembl:ENST00000675502|ensembl:ENSP00000502428|ensembl:ENST00000675801|ensembl:ENSP00000502688|ensembl:ENST00000675865|ensembl:ENSP00000502003|ensembl:ENST00000676226|ensembl:ENSP00000502325|ensembl:ENST00000256830|ensembl:ENSP00000256830|ensembl:ENST00000356462|ensembl:ENSP00000348847|ensembl:ENST00000357895|ensembl:ENSP00000350569|ensembl:ENST00000382850|refseq:XP_016881168.1|refseq:NP_001138443.1|ensembl:ENSG00000049759(gene)|ensembl:ENST00000400345(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0010038"(response to metal ion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030104"(water homeostasis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:2LTY|rcsb pdb:2MPT|rcsb pdb:2NSQ|rcsb pdb:2ONI|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:5HPK|reactome:R-HSA-162588|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-2672351|reactome:R-HSA-983168|mint:Q96PU5|dip:DIP-41935N	-	-	-	figure legend:4C|comment:PY motif mutagenesis revealed that aArr-E3 interactions were PY-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rogid:HrKtKY/e1+GYwm5PbBxMO+7XOc09606	rigid:OODjcTSQ9erpYUfnvETHkXmLZiI	false	flag tag:c-c|mutation disrupting interaction strength:347-347,349-349,392-392,394-394	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q96B67	uniprotkb:Q96J02	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682257|imex:IM-25078-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	-	-	-	figure legend:4C|comment:PY motif mutagenesis revealed that aArr-E3 interactions were PY-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rigid:OODjcTSQ9erpYUfnvETHkXmLZiI	false	flag tag:c-c|mutation disrupting interaction strength:347-347,349-349,392-392,394-394	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NCT1	uniprotkb:O00308	intact:EBI-11673273|uniprotkb:Q6NSI9|intact:EBI-28978776|ensembl:ENSP00000268042	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:arrd4_human(display_long)|uniprotkb:ARRDC4(gene name)|psi-mi:ARRDC4(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682285|imex:IM-25078-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000268042|refseq:NP_899232.2|ensembl:ENSG00000140450(gene)|ensembl:ENST00000268042(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:4D|comment:PY motif mutagenesis revealed that aArr-E3 interactions were PY-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:LefCyMgfWvQUaEez5JFZLOHO8tg9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:9VHoZP6f6yl+VTbT9wt+lLQIfjU	false	flag tag:c-c|mutation disrupting interaction strength:351-351,353-353,396-396,398-398	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NCT1	uniprotkb:Q96PU5	intact:EBI-11673273|uniprotkb:Q6NSI9|intact:EBI-28978776|ensembl:ENSP00000268042	intact:EBI-717962|uniprotkb:O43165|uniprotkb:Q7Z5F1|uniprotkb:Q7Z5F2|uniprotkb:Q7Z5N3|uniprotkb:Q8N5A7|uniprotkb:Q8WUU9|uniprotkb:Q9BW58|uniprotkb:Q9H2W4|uniprotkb:Q9NT88|uniprotkb:Q3LSM7|intact:EBI-28979180|ensembl:ENSP00000383199	psi-mi:arrd4_human(display_long)|uniprotkb:ARRDC4(gene name)|psi-mi:ARRDC4(display_short)	psi-mi:ned4l_human(display_long)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:NEDD4L(gene name)|psi-mi:NEDD4L(display_short)|uniprotkb:KIAA0439(gene name synonym)|uniprotkb:NEDL3(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682285|imex:IM-25078-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000268042|refseq:NP_899232.2|ensembl:ENSG00000140450(gene)|ensembl:ENST00000268042(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	refseq:NP_001138436.1|refseq:NP_001138437.1|refseq:NP_001138438.1|refseq:NP_001138439.1|refseq:NP_001138440.1|refseq:NP_001138441.1|refseq:NP_001138442.1|refseq:NP_056092.2|refseq:NP_001230889.1|ensembl:ENSP00000383199|ensembl:ENSP00000372301|ensembl:ENST00000431212|ensembl:ENSP00000389406|ensembl:ENST00000435432|ensembl:ENSP00000393395|ensembl:ENST00000456173|ensembl:ENSP00000405440|ensembl:ENST00000456986|ensembl:ENSP00000411947|ensembl:ENST00000586263|ensembl:ENSP00000468546|ensembl:ENST00000674517|ensembl:ENSP00000501665|ensembl:ENST00000675502|ensembl:ENSP00000502428|ensembl:ENST00000675801|ensembl:ENSP00000502688|ensembl:ENST00000675865|ensembl:ENSP00000502003|ensembl:ENST00000676226|ensembl:ENSP00000502325|ensembl:ENST00000256830|ensembl:ENSP00000256830|ensembl:ENST00000356462|ensembl:ENSP00000348847|ensembl:ENST00000357895|ensembl:ENSP00000350569|ensembl:ENST00000382850|refseq:XP_016881168.1|refseq:NP_001138443.1|ensembl:ENSG00000049759(gene)|ensembl:ENST00000400345(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0010038"(response to metal ion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030104"(water homeostasis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:2LTY|rcsb pdb:2MPT|rcsb pdb:2NSQ|rcsb pdb:2ONI|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:5HPK|reactome:R-HSA-162588|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-2672351|reactome:R-HSA-983168|mint:Q96PU5|dip:DIP-41935N	-	-	-	figure legend:4D|comment:PY motif mutagenesis revealed that aArr-E3 interactions were PY-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:LefCyMgfWvQUaEez5JFZLOHO8tg9606	rogid:HrKtKY/e1+GYwm5PbBxMO+7XOc09606	rigid:9VHoZP6f6yl+VTbT9wt+lLQIfjU	false	flag tag:c-c|mutation disrupting interaction strength:351-351,353-353,396-396,398-398	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8NCT1	uniprotkb:Q96J02	intact:EBI-11673273|uniprotkb:Q6NSI9|intact:EBI-28978776|ensembl:ENSP00000268042	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:arrd4_human(display_long)|uniprotkb:ARRDC4(gene name)|psi-mi:ARRDC4(display_short)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682285|imex:IM-25078-23	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000268042|refseq:NP_899232.2|ensembl:ENSG00000140450(gene)|ensembl:ENST00000268042(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	-	-	-	figure legend:4D|comment:PY motif mutagenesis revealed that aArr-E3 interactions were PY-dependent.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:LefCyMgfWvQUaEez5JFZLOHO8tg9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rigid:9VHoZP6f6yl+VTbT9wt+lLQIfjU	false	flag tag:c-c|mutation disrupting interaction strength:351-351,353-353,396-396,398-398	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07550	uniprotkb:Q96J02	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682335|imex:IM-25078-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	-	-	-	figure legend:5C|agonist:"CHEBI:64317:isoproterenol (Isoprenaline) - a non-selective beta-adrenoreceptor agonist that is structurally similar to  adrenaline."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rigid:lVMelOMFwRV/eDdCr6QBkV4cTcw	false	ha tag:n-n|v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07550	uniprotkb:Q96B67	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682335|imex:IM-25078-25	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	-	-	-	figure legend:5C|agonist:"CHEBI:64317:isoproterenol (Isoprenaline) - a non-selective beta-adrenoreceptor agonist that is structurally similar to  adrenaline."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:lVMelOMFwRV/eDdCr6QBkV4cTcw	false	ha tag:n-n|v5 tag:c-c	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P30518	uniprotkb:Q8NCT1	intact:EBI-11675746|uniprotkb:C5HF20|uniprotkb:O43192|uniprotkb:Q3MJD3|uniprotkb:Q9UCV9|ensembl:ENSP00000338072|ensembl:ENSP00000496396	intact:EBI-11673273|uniprotkb:Q6NSI9|intact:EBI-28978776|ensembl:ENSP00000268042	psi-mi:v2r_human(display_long)|uniprotkb:AVPR V2(gene name synonym)|uniprotkb:Antidiuretic hormone receptor(gene name synonym)|uniprotkb:Renal-type arginine vasopressin receptor(gene name synonym)|uniprotkb:AVPR2(gene name)|psi-mi:AVPR2(display_short)|uniprotkb:ADHR(gene name synonym)|uniprotkb:DIR(gene name synonym)|uniprotkb:DIR3(gene name synonym)|uniprotkb:V2R(gene name synonym)	psi-mi:arrd4_human(display_long)|uniprotkb:ARRDC4(gene name)|psi-mi:ARRDC4(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11681829|imex:IM-25078-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000045.1|refseq:NP_001139623.1|refseq:XP_006724891.1|ensembl:ENST00000337474(transcript)|ensembl:ENST00000646375(transcript)|go:"GO:0001992"(regulation of systemic arterial blood pressure by vasopressin)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005000"(vasopressin receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|ensembl:ENSG00000126895(gene)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007588"(excretion)|go:"GO:0007599"(hemostasis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021537"(telencephalon development)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0034097"(response to cytokine)|go:"GO:0035811"(negative regulation of urine volume)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042277"(peptide binding)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000161(Vasopressin V2 receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001817(Vasopressin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:4JQI|rcsb pdb:6NI2|rcsb pdb:6U1N|rcsb pdb:7BB6|rcsb pdb:7BB7|rcsb pdb:7KH0|reactome:R-HSA-388479|reactome:R-HSA-418555|reactome:R-HSA-432040|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9036092|reactome:R-HSA-9660821	ensembl:ENSP00000268042|refseq:NP_899232.2|ensembl:ENSG00000140450(gene)|ensembl:ENST00000268042(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	-	-	-	figure legend:3A|agonist:"AVP-Arginine-vasopressin -UniProt ID:PRO_0000020515"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:zjK7PcQaMOPOsDBE0WhsVpAi4nA9606	rogid:LefCyMgfWvQUaEez5JFZLOHO8tg9606	rigid:dQFduu7iv801o5N4XWrFNI0G62U	false	ha tag:n-n|v5 tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P07550	uniprotkb:Q96B67	intact:EBI-491169|uniprotkb:Q9UH95|uniprotkb:Q9UHA1|uniprotkb:O14823|uniprotkb:O14824|uniprotkb:O14825|uniprotkb:O14826|uniprotkb:Q4JG18|uniprotkb:Q8NEQ9|uniprotkb:Q9UMZ5|uniprotkb:Q6P4D8|uniprotkb:B0LPE4|uniprotkb:B2R7X2|uniprotkb:Q53GA6|uniprotkb:Q6GMT4|uniprotkb:Q96EC3|uniprotkb:Q9UCZ0|uniprotkb:Q9UCZ1|uniprotkb:Q9UCZ2|uniprotkb:Q9UCZ3|ensembl:ENSP00000305372	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:adrb2_human(display_long)|uniprotkb:Beta-2 adrenoreceptor(gene name synonym)|uniprotkb:ADRB2(gene name)|psi-mi:ADRB2(display_short)|uniprotkb:ADRB2R(gene name synonym)|uniprotkb:B2AR(gene name synonym)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11681846|imex:IM-25078-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000015.1|ensembl:ENSG00000169252(gene)|ensembl:ENST00000305988(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004941"(beta2-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007171"(activation of transmembrane receptor protein tyrosine kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0009409"(response to cold)|go:"GO:0010008"(endosome membrane)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031649"(heat generation)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0061885"(positive regulation of mini excitatory postsynaptic potential)|go:"GO:0071875"(adrenergic receptor signaling pathway)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901098"(positive regulation of autophagosome maturation)|go:"GO:1904504"(positive regulation of lipophagy)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000332(Adrenergic receptor, beta 2)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P07550|rcsb pdb:1GQ4|rcsb pdb:2R4R|rcsb pdb:2R4S|rcsb pdb:2RH1|rcsb pdb:3D4S|rcsb pdb:3KJ6|rcsb pdb:3NY8|rcsb pdb:3NY9|rcsb pdb:3NYA|rcsb pdb:3P0G|rcsb pdb:3PDS|rcsb pdb:3SN6|rcsb pdb:4GBR|rcsb pdb:4LDE|rcsb pdb:4LDL|rcsb pdb:4LDO|rcsb pdb:4QKX|rcsb pdb:5D5A|rcsb pdb:5D5B|rcsb pdb:5D6L|rcsb pdb:5JQH|rcsb pdb:5X7D|rcsb pdb:6E67|rcsb pdb:6KR8|rcsb pdb:6MXT|rcsb pdb:6N48|rcsb pdb:6NI3|rcsb pdb:6OBA|rcsb pdb:6PRZ|rcsb pdb:6PS0|rcsb pdb:6PS1|rcsb pdb:6PS2|rcsb pdb:6PS3|rcsb pdb:6PS4|rcsb pdb:6PS5|rcsb pdb:6PS6|rcsb pdb:7BZ2|rcsb pdb:7DHI|rcsb pdb:7DHR|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-5689880|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9660821|dip:DIP-33948N	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	-	-	-	figure legend:3A|agonist:"CHEBI:64317:isoproterenol (Isoprenaline) - a non-selective beta-adrenoreceptor agonist that is structurally similar to  adrenaline."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2016/03/08	2016/03/31	rogid:+pZmEUm9SKroeqpa7uI44Bz18zo9606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:1RxAR2NSef42vP0gn5Tvt2Hrvpc	false	ha tag:n-n|v5 tag:c-c	flag tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8N5I2	uniprotkb:Q96J02	intact:EBI-2339564|ensembl:ENSP00000360475	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:arrd1_human(display_long)|uniprotkb:Alpha-arrestin 1(gene name synonym)|uniprotkb:ARRDC1(gene name)|psi-mi:ARRDC1(display_short)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682056|imex:IM-25078-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689498.1|ensembl:ENSP00000360475|ensembl:ENSG00000197070(gene)|ensembl:ENST00000371421(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006858"(extracellular transport)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/03/31	rogid:Q776M1DBnxGDHoHAqS666mel0hM9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rigid:JTPyNy5Vi+jm5ZkO/EWjSZ/ii8M	false	sufficient binding region:365..365-433	sufficient binding region:326..326-511..511(IPR001202)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96J02	uniprotkb:Q96B67	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682064|imex:IM-25078-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168|interpro:IPR001202(WW/Rsp5/WWP)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	-	-	-	figure legend:4Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/04/01	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:BJADsSeBwYQG6nm8QL+3ZSsf9c8	false	sufficient binding region:326..326-511..511(IPR001202)	sufficient binding region:335-414	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96B67	uniprotkb:O00308	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682151|imex:IM-25078-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:4A-3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/03/31	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:esJZ3rQgwep4C9mQWTqb5sxvf+A	false	sufficient binding region:335-414	sufficient binding region:300..300-477..477(IPR001202)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96PU5	uniprotkb:Q96B67	intact:EBI-717962|uniprotkb:O43165|uniprotkb:Q7Z5F1|uniprotkb:Q7Z5F2|uniprotkb:Q7Z5N3|uniprotkb:Q8N5A7|uniprotkb:Q8WUU9|uniprotkb:Q9BW58|uniprotkb:Q9H2W4|uniprotkb:Q9NT88|uniprotkb:Q3LSM7|intact:EBI-28979180|ensembl:ENSP00000383199	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	psi-mi:ned4l_human(display_long)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:NEDD4L(gene name)|psi-mi:NEDD4L(display_short)|uniprotkb:KIAA0439(gene name synonym)|uniprotkb:NEDL3(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym)	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682182|imex:IM-25078-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138436.1|refseq:NP_001138437.1|refseq:NP_001138438.1|refseq:NP_001138439.1|refseq:NP_001138440.1|refseq:NP_001138441.1|refseq:NP_001138442.1|refseq:NP_056092.2|refseq:NP_001230889.1|ensembl:ENSP00000383199|ensembl:ENSP00000372301|ensembl:ENST00000431212|ensembl:ENSP00000389406|ensembl:ENST00000435432|ensembl:ENSP00000393395|ensembl:ENST00000456173|ensembl:ENSP00000405440|ensembl:ENST00000456986|ensembl:ENSP00000411947|ensembl:ENST00000586263|ensembl:ENSP00000468546|ensembl:ENST00000674517|ensembl:ENSP00000501665|ensembl:ENST00000675502|ensembl:ENSP00000502428|ensembl:ENST00000675801|ensembl:ENSP00000502688|ensembl:ENST00000675865|ensembl:ENSP00000502003|ensembl:ENST00000676226|ensembl:ENSP00000502325|ensembl:ENST00000256830|ensembl:ENSP00000256830|ensembl:ENST00000356462|ensembl:ENSP00000348847|ensembl:ENST00000357895|ensembl:ENSP00000350569|ensembl:ENST00000382850|refseq:XP_016881168.1|refseq:NP_001138443.1|ensembl:ENSG00000049759(gene)|ensembl:ENST00000400345(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0010038"(response to metal ion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030104"(water homeostasis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:2LTY|rcsb pdb:2MPT|rcsb pdb:2NSQ|rcsb pdb:2ONI|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:5HPK|reactome:R-HSA-162588|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-2672351|reactome:R-HSA-983168|mint:Q96PU5|dip:DIP-41935N	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	-	-	-	figure legend:4A-4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/03/31	rogid:HrKtKY/e1+GYwm5PbBxMO+7XOc09606	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rigid:BtZdFtLyu9f3XJVyqMLs7Z44+xY	false	sufficient binding region:193..193-581..581(IPR001202)	sufficient binding region:335-414	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96B67	uniprotkb:Q86UL8	intact:EBI-2875665|intact:EBI-28982382|ensembl:ENSP00000265138|uniprotkb:A8K6T8|uniprotkb:Q9P2H1	intact:EBI-311035|uniprotkb:O60434|uniprotkb:O60510|uniprotkb:Q86UI7|uniprotkb:Q9NP44|uniprotkb:Q9UDQ5|uniprotkb:Q9UDU1|uniprotkb:A4D1C1|uniprotkb:A7E2C3|intact:EBI-28973920|ensembl:ENSP00000346151	psi-mi:arrd3_human(display_long)|uniprotkb:KIAA1376(gene name synonym)|uniprotkb:TBP-2-like inducible membrane protein(gene name synonym)|uniprotkb:ARRDC3(gene name)|psi-mi:ARRDC3(display_short)	psi-mi:magi2_human(display_long)|uniprotkb:MAGI2(gene name)|psi-mi:MAGI2(display_short)|uniprotkb:KIAA0705(gene name synonym)|uniprotkb:ACVRINP1(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Atrophin-1-interacting protein A(gene name synonym)|uniprotkb:AIP1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682191|imex:IM-25078-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000113369(gene)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031651"(negative regulation of heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0043588"(skin development)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060613"(fat pad development)|go:"GO:0071878"(negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0090327"(negative regulation of locomotion involved in locomotory behavior)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|rcsb pdb:4N7H|rcsb pdb:4R7V|rcsb pdb:4R7X|ensembl:ENST00000265138(transcript)|refseq:NP_065852.1|ensembl:ENSP00000265138	ensembl:ENSP00000346151|ensembl:ENST00000419488|ensembl:ENSP00000405766|refseq:NP_036433.2|refseq:NP_001288057.1|ensembl:ENSG00000187391(gene)|ensembl:ENST00000354212(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003402"(planar cell polarity pathway involved in axis elongation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030036|interpro:IPR036020|interpro:IPR036034|mint:Q86UL8|rcsb pdb:1UEP|rcsb pdb:1UEQ|rcsb pdb:1UEW|rcsb pdb:1UJV|rcsb pdb:1WFV|reactome:R-HSA-373753|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043113"(receptor clustering)	-	-	-	figure legend:4A-5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/03/31	rogid:XPgatMsOEeWbHJXTkQZsNXaWuNs9606	rogid:/uTMSMqB1wrlyHj2P9OVVBCpWcY9606	rigid:n2BM1lA1NNwgWjMNKBrSFwLvw3Q	false	sufficient binding region:335-414	sufficient binding region:302..302-381..381(IPR001202)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62834	uniprotkb:Q12967	intact:EBI-491414|uniprotkb:P10113|ensembl:ENSP00000348786|ensembl:ENSP00000358723|intact:EBI-1047696	intact:EBI-365861|uniprotkb:Q9P2N8|uniprotkb:Q9HAX7|uniprotkb:Q9HAY1|uniprotkb:Q9HCT1|ensembl:ENSP00000361120|uniprotkb:B7Z753|uniprotkb:E7ER93|uniprotkb:E7ERZ0|uniprotkb:Q6PCE1|uniprotkb:Q6ZSD5|uniprotkb:Q5T7V4|uniprotkb:Q6KH11	psi-mi:rap1a_human(display_long)|uniprotkb:GTP-binding protein smg p21A(gene name synonym)|uniprotkb:Ras-related protein Krev-1(gene name synonym)|uniprotkb:C21KG(gene name synonym)|uniprotkb:G-22K(gene name synonym)|uniprotkb:RAP1A(gene name)|psi-mi:RAP1A(display_short)|uniprotkb:KREV1(gene name synonym)	psi-mi:gnds_human(display_long)|uniprotkb:RALGDS(gene name)|psi-mi:RALGDS(display_short)|uniprotkb:RGF(gene name synonym)|uniprotkb:KIAA1308(gene name synonym)|uniprotkb:Ral guanine nucleotide exchange factor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682848|imex:IM-25078-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0097421"(liver regeneration)|refseq:NP_001278825.1|refseq:NP_001010935.1|refseq:NP_002875.1|go:"GO:0035579"(specific granule membrane)|go:"GO:0035690"|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|ensembl:ENSG00000116473(gene)|ensembl:ENST00000356415(transcript)|ensembl:ENST00000369709(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007399"(nervous system development)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010008"(endosome membrane)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0030054"(cell junction)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR038851|rcsb pdb:1C1Y|rcsb pdb:1GUA|rcsb pdb:3KUC|rcsb pdb:4KVG|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-354192|reactome:R-HSA-354194|reactome:R-HSA-372708|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8875555|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:XP_016857451.1|refseq:XP_016857452.1|refseq:XP_016857453.1|dip:DIP-29106N	ensembl:ENSG00000160271(gene)|ensembl:ENST00000372050(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0030695"(GTPase regulator activity)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR015758(Guanine nucleotide dissociation stimulator RalGDS)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036964|rcsb pdb:1RAX|rcsb pdb:2B3A|rcsb pdb:2RGF|rcsb pdb:3KH0|reactome:R-HSA-171007|reactome:R-HSA-5673001|refseq:NP_006257.1|refseq:NP_001035827.1|refseq:NP_001258703.1|refseq:NP_001258705.1|ensembl:ENST00000372062|ensembl:ENSP00000361132|ensembl:ENST00000393157|ensembl:ENSP00000376864|ensembl:ENST00000393160|ensembl:ENSP00000376867|ensembl:ENSP00000361120|ensembl:ENST00000372047|ensembl:ENSP00000361117|refseq:NP_001258704.1|dip:DIP-31375N	-	-	-	figure legend:4A|comment:Strong positive control.  A mutant  Prey plasmid pEXP22/RALGDS-m1 with an unknown mutation acts as a weak positive control.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/04/01	rogid:QtjMjJiMQF0CbTD40IZgca4XfIU9606	rogid:7h1pcwLfOmg7huN2863/7lzWlyI9606	rigid:+/BAI+fgZgNyykDW92O+bQFnUEM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N5I2	uniprotkb:O00308	intact:EBI-2339564|ensembl:ENSP00000360475	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	psi-mi:arrd1_human(display_long)|uniprotkb:Alpha-arrestin 1(gene name synonym)|uniprotkb:ARRDC1(gene name)|psi-mi:ARRDC1(display_short)	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Shea et al. (2011)	imex:IM-25078|pubmed:23236378	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11682854|imex:IM-25078-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689498.1|ensembl:ENSP00000360475|ensembl:ENSG00000197070(gene)|ensembl:ENST00000371421(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006858"(extracellular transport)|go:"GO:0015031"(protein transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0140112"(extracellular vesicle biogenesis)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	-	-	-	figure legend:4A-2i|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2016/03/08	2016/04/01	rogid:Q776M1DBnxGDHoHAqS666mel0hM9606	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rigid:+4OTJhaknlFRp2v1DaymAS3C7DU	false	sufficient binding region:365..365-433	sufficient binding region:300..300-477..477(IPR001202)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)