#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8IU57 uniprotkb:Q8IU54-PRO_0000015511 intact:EBI-373215|uniprotkb:Q6ZML8|uniprotkb:Q8IZI7|uniprotkb:Q8IZI8|intact:EBI-28972324|ensembl:ENSP00000327824|uniprotkb:Q5VTX5|uniprotkb:Q5VTX8|uniprotkb:Q5VTX7|uniprotkb:Q8IV66 intact:EBI-11506462 psi-mi:inlr1_human(display_long)|uniprotkb:IFNLR1(gene name)|psi-mi:IFNLR1(display_short)|uniprotkb:Cytokine receptor class-II member 12(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 12(gene name synonym)|uniprotkb:IL28RA(gene name synonym)|uniprotkb:LICR2(gene name synonym)|uniprotkb:Likely interleukin or cytokine receptor 2(gene name synonym)|uniprotkb:Interleukin-28 receptor subunit alpha(gene name synonym) psi-mi:q8iu54-pro_0000015511(display_long)|uniprotkb:IFNL1(gene name)|psi-mi:IFNL1(display_short)|uniprotkb:IL29(gene name synonym)|uniprotkb:ZCYTO21(gene name synonym)|uniprotkb:Cytokine Zcyto21(gene name synonym)|uniprotkb:Interleukin-29(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Miknis et al. (2010) imex:IM-24871|pubmed:20934432 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474247|wwpdb:3og6|imex:IM-24871-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_734464.1|refseq:NP_775087.1|refseq:NP_775088.1|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:3OG4|rcsb pdb:3OG6|rcsb pdb:5IXD|rcsb pdb:5IXI|ensembl:ENSG00000185436(gene)|ensembl:ENST00000327535(transcript)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0034342"(response to type III interferon)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|rcsb pdb:5L04|ensembl:ENSP00000327824|ensembl:ENST00000327575|ensembl:ENSP00000328994|ensembl:ENST00000374418|ensembl:ENSP00000363539|ensembl:ENST00000374421|ensembl:ENSP00000363542|rcsb pdb:5T5W|reactome:R-HSA-449836|reactome:R-HSA-8854691|dip:DIP-31197N intact:EBI-11474210(chain-parent) - - chain-seq-start:20|chain-seq-end:200 figure legend:Table 1|3d-resolution:2.1A|3d-r-factors:R work 0.184, R free 0.228|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/01/05 2016/01/18 rogid:ISmlnH5Eu8E5JLxQ2XK6IuV2ZlA9606 rogid:2QWmp/beLpuoopwKclyW225SxdI9606 rigid:46SFjx8XVEzINmpcamOktHLQt0w false tag:n-n|sufficient binding region:19-226|his tag:?-? his tag:n-n|tag:n-n 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q8IU57 uniprotkb:Q8IU54 intact:EBI-373215|uniprotkb:Q6ZML8|uniprotkb:Q8IZI7|uniprotkb:Q8IZI8|intact:EBI-28972324|ensembl:ENSP00000327824|uniprotkb:Q5VTX5|uniprotkb:Q5VTX8|uniprotkb:Q5VTX7|uniprotkb:Q8IV66 intact:EBI-11474210|uniprotkb:A0AV25|uniprotkb:Q17R34|ensembl:ENSP00000329991 psi-mi:inlr1_human(display_long)|uniprotkb:IFNLR1(gene name)|psi-mi:IFNLR1(display_short)|uniprotkb:Cytokine receptor class-II member 12(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 12(gene name synonym)|uniprotkb:IL28RA(gene name synonym)|uniprotkb:LICR2(gene name synonym)|uniprotkb:Likely interleukin or cytokine receptor 2(gene name synonym)|uniprotkb:Interleukin-28 receptor subunit alpha(gene name synonym) psi-mi:ifnl1_human(display_long)|uniprotkb:IFNL1(gene name)|psi-mi:IFNL1(display_short)|uniprotkb:IL29(gene name synonym)|uniprotkb:ZCYTO21(gene name synonym)|uniprotkb:Cytokine Zcyto21(gene name synonym)|uniprotkb:Interleukin-29(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Miknis et al. (2010) imex:IM-24871|pubmed:20934432 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-11474262|wwpdb:3og4|imex:IM-24871-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_734464.1|refseq:NP_775087.1|refseq:NP_775088.1|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:3OG4|rcsb pdb:3OG6|rcsb pdb:5IXD|rcsb pdb:5IXI|ensembl:ENSG00000185436(gene)|ensembl:ENST00000327535(transcript)|go:"GO:0002385"(mucosal immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0034342"(response to type III interferon)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|rcsb pdb:5L04|ensembl:ENSP00000327824|ensembl:ENST00000327575|ensembl:ENSP00000328994|ensembl:ENST00000374418|ensembl:ENSP00000363539|ensembl:ENST00000374421|ensembl:ENSP00000363542|rcsb pdb:5T5W|reactome:R-HSA-449836|reactome:R-HSA-8854691|dip:DIP-31197N refseq:NP_742152.1|ensembl:ENSG00000182393(gene)|ensembl:ENST00000333625(transcript)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0032003"(interleukin-28 receptor binding)|go:"GO:0032696"(negative regulation of interleukin-13 production)|go:"GO:0032714"(negative regulation of interleukin-5 production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043381"(negative regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR029177|interpro:IPR038326|rcsb pdb:3OG4|rcsb pdb:3OG6|reactome:R-HSA-449836|reactome:R-HSA-8854691 - - - figure legend:Table 1|3d-resolution:2.16A|3d-r-factors:R work 0.198, R free 0.24|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/01/05 2016/01/05 rogid:ISmlnH5Eu8E5JLxQ2XK6IuV2ZlA9606 rogid:1haocnERdzeQf4vU7/h12qwA3c49606 rigid:OsoBN1U0POvTkKPvUkjI7rHZIaM false his tag:?-?|tag:n-n|sufficient binding region:19-226 sufficient binding region:23-200 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)