#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790475|imex:IM-25381-51	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:1|comment:Material isolated from a much  smaller peak indicated that this species is composed of 16 promoter subunits.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	-	-	8	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0826"(x ray scattering)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790569|imex:IM-25381-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:3|comment:"The protein is composed of four globular domains (each with a diameter of ∼4 nm) arranged into tetramers."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	-	-	8	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790634|imex:IM-25381-31	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:4B, 5A|comment:The C_PTX3 fragment does not oligomerise.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/06/28	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	mutation disrupting interaction strength:103-103,47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	mutation disrupting interaction strength:103-103,47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	2	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790643|imex:IM-25381-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:4Bi, 5A|comment:The C_PTX3 fragment  does not oligomerise.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	mutation disrupting interaction strength:103-103|mutation disrupting interaction strength:47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	mutation disrupting interaction strength:103-103|mutation disrupting interaction strength:47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	4	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790699|imex:IM-25381-33	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:5B|comment:Non-covalent associations between N_PTX3 monomers mediate dimerization.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/06/28	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	mutation:103-103,47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	mutation:103-103,47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790923|imex:IM-25381-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:4Ci, 5B|comment:The single and double mutant proteins both corresponded to a mixture of tetramers and dimers|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n|mutation decreasing interaction strength:103-103|mutation decreasing interaction strength:49-49,47-47	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n|mutation decreasing interaction strength:103-103|mutation decreasing interaction strength:49-49,47-47	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790955|imex:IM-25381-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:5Bi|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/06/28	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	mutation:47-47,49-49|mutation:103-103|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	mutation:47-47,49-49|mutation:103-103|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11790899|imex:IM-25381-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:5C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/06/28	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	mutation:103-103|mutation:47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	mutation:103-103|mutation:47-47,49-49|his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791009|imex:IM-25381-35	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7A, Supp 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/08/08	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	-	2	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791579|imex:IM-25381-57	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791601|imex:IM-25381-43	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791026|imex:IM-25381-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/08/05	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	-	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791046|imex:IM-25381-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/28	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791156|imex:IM-25381-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7Di, Supp 7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/28	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	sufficient binding region:18-170|v5 tag:c-c|his tag:c-c|mutation decreasing interaction strength:103-103|mutation disrupting interaction strength:103-103,47-47,49-49	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0892"(solid phase assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791221|imex:IM-25381-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0892"(solid phase assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791207|imex:IM-25381-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7Eii, Supp 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	sufficient binding region:18-170|v5 tag:c-c|his tag:c-c|mutation disrupting interaction strength:103-103,47-47,49-49|biotin tag:?-?|mutation decreasing interaction strength:103-103	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0892"(solid phase assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791207|imex:IM-25381-37	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7Eii, Supp 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0892"(solid phase assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791300|imex:IM-25381-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7Ei|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0892"(solid phase assay)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791300|imex:IM-25381-19	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7Ei|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/06/29	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791375|imex:IM-25381-39	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7F|comment:"Both the disulfide-linked tetramer (4-mer) and disulfide-linked dimer (2-mer), bound to bFGF2"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/08/08	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	biotin tag:?-?	sufficient binding region:18-170|v5 tag:c-c|his tag:c-c	-	2	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P09038	uniprotkb:P26022	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791611|imex:IM-25381-45	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:7F|comment:"Both the disulfide-linked tetramer (4-mer) and disulfide-linked dimer (2-mer), bound to bFGF2"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/06/01	2016/08/08	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:bL4PmGU29erDRpnsPN6r4PrEGyM	false	biotin tag:?-?	sufficient binding region:18-170|v5 tag:c-c|his tag:c-c	-	4	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791488|imex:IM-25381-53	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 3A|comment:Stoichiometry has been inferred by similarity to the purified recombinant protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8387)|taxid:9606(human fibrosarcoma  cell line 8387)	-	2016/06/01	2016/08/08	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	-	-	8	0	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0071"(molecular sieving)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791574|imex:IM-25381-55	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 3B|comment:Stoichiometry has been inferred by similarity to the purified recombinant protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8387)|taxid:9606(human fibrosarcoma  cell line 8387)	-	2016/06/01	2016/08/08	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	-	-	8	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11791471|imex:IM-25381-41	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2016/06/01	2016/08/08	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	-	-	8	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12499652|imex:IM-25381-49	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp 2A|comment:The C_PTX3 fragment does not oligomerise.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293f)|taxid:9606(Homo sapiens HEK293F cell line)	-	2016/06/01	2016/08/08	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:/A4XkqraEviPzFUrFY+IeQsv7EE	false	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	his tag:c-c|sufficient binding region:18-170|v5 tag:n-n	4	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0020"(transmission electron microscopy)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12499468|imex:IM-25381-47	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:2|comment:The protein is composed of four globular domains  arranged into tetramers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:PuVQI3k8uw0nAHtYfuVsntgy9cU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0020"(transmission electron microscopy)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12499485|imex:IM-25381-59	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:Supp fig 3 C/D|comment:The protein is composed of four globular domains  arranged into tetramers.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-8387)|taxid:9606(human fibrosarcoma  cell line 8387)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:PuVQI3k8uw0nAHtYfuVsntgy9cU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26022	uniprotkb:P26022	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	intact:EBI-11574553|uniprotkb:B2R6T6|uniprotkb:Q38M82|ensembl:ENSP00000295927	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:ptx3_human(display_long)|uniprotkb:Pentaxin-related protein PTX3(gene name synonym)|uniprotkb:TNFAIP5(gene name synonym)|uniprotkb:TSG14(gene name synonym)|uniprotkb:Tumor necrosis factor alpha-induced protein 5(gene name synonym)|uniprotkb:Tumor necrosis factor-inducible gene 14 protein(gene name synonym)|uniprotkb:PTX3(gene name)|psi-mi:PTX3(display_short)	psi-mi:"MI:0982"(electrophoretic mobility-based method)	Inforzato et al. (2010)	pubmed:20363749|imex:IM-25381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-12499529|imex:IM-25381-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	refseq:NP_002843.2|ensembl:ENSG00000163661(gene)|ensembl:ENST00000295927(transcript)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0001872"("(1->3)-beta-D-glucan binding")|go:"GO:0001878"(response to yeast)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0044869"(negative regulation by host of viral exo-alpha-sialidase activity)|go:"GO:0044871"(negative regulation by host of viral glycoprotein metabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:1903016"(negative regulation of exo-alpha-sialidase activity)|go:"GO:1903019"(negative regulation of glycoprotein metabolic process)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR001759(Pentaxin)|interpro:IPR006558(LamG-like jellyroll fold)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|interpro:IPR042837|reactome:R-HSA-6798695	-	-	-	figure legend:4B|comment:Molecular weight was greater than 210kDa.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10029(crigr-cho)|taxid:10029(chinese hamster ovary cell line)	-	2016/06/01	2016/08/05	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rogid:E2p0QaxS5/8mpgyOghoPCB+WHx09606	rigid:PuVQI3k8uw0nAHtYfuVsntgy9cU	false	-	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)