#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BY76 uniprotkb:Q05793 intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670 intact:EBI-1032089 psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name) psi-mi:pgbm_mouse(display_long)|uniprotkb:Hspg2(gene name)|psi-mi:Hspg2(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12599349 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1 refseq:NP_032331.2|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR000034(Laminin B)|interpro:IPR001791(Laminin G)|interpro:IPR000082(SEA)|interpro:IPR023415|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|rcsb pdb:1GL4|reactome:R-MMU-1474228|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-975634|mint:Q05793|interpro:IPR036055|interpro:IPR036179 - - - figure legend:Fig. 2B|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606 rogid:cSZXdrVzYrrPDxo2+9QWAlImMbQ10090 rigid:plrGEVpYj/y+BLxN47eWd9OsO80 false myc tag:c-c|his tag:c-c|sufficient binding region:22-170 heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:71-71,65-65,76-76 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:Q9BY76 intact:EBI-2566501 intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0917"(matrixdb) intact:EBI-12599391 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1 - - - comment:The SPR data were best fitted by a bivalent analyte model, which corresponds to the presence of two heparin-binding sites on ANGPTL4.|figure legend:Fig. 2C, Table 2, Suppl Fig. 4|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/18 - rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606 - false - myc tag:c-c|his tag:c-c|sufficient binding region:22-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:Q05793 intact:EBI-2566501 intact:EBI-1032089 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:pgbm_mouse(display_long)|uniprotkb:Hspg2(gene name)|psi-mi:Hspg2(display_short) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12599994 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) refseq:NP_032331.2|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR000034(Laminin B)|interpro:IPR001791(Laminin G)|interpro:IPR000082(SEA)|interpro:IPR023415|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002020"(protease binding)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0060351"(cartilage development involved in endochondral bone morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|rcsb pdb:1GL4|reactome:R-MMU-1474228|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-975634|mint:Q05793|interpro:IPR036055|interpro:IPR036179 - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - rogid:cSZXdrVzYrrPDxo2+9QWAlImMbQ10090 - false - heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:65-65|heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:71-71|heparan sulfate D-glucuronosyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine:76-76 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:Q9BY76 intact:EBI-2566501 intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12599994 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1 - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606 - false - myc tag:c-c|his tag:c-c|sufficient binding region:22-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" chebi:"CHEBI:28304" intact:EBI-2566501 intact:EBI-1379423 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12600004 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) matrixdb:GAG_2(source reference) - - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:Q9BY76 intact:EBI-2566501 intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12600004 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1 - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606 - false - sufficient binding region:22-170|myc tag:c-c|his tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" chebi:"CHEBI:28815" intact:EBI-2566501 intact:EBI-2566501 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12600009 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) matrixdb:GAG_2(source reference) matrixdb:GAG_2(source reference) - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:Q9BY76 intact:EBI-2566501 intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12600009 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1 - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606 - false - myc tag:c-c|his tag:c-c|sufficient binding region:22-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" chebi:"CHEBI:18376" intact:EBI-2566501 intact:EBI-2566541 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:dermatan_sulfate(display_short)|psi-mi:"CHEBI:18376"(display_long) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12600014 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0941"(competitor) psi-mi:"MI:0496"(bait) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0328"(small molecule) matrixdb:GAG_2(source reference) matrixdb:GAG_3(source reference) - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - - - false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28815" uniprotkb:Q9BY76 intact:EBI-2566501 intact:EBI-2968146|ensembl:ENSP00000301455|ensembl:ENSP00000472551|uniprotkb:A8MY84|uniprotkb:Q53HQ6|uniprotkb:Q9NZU4|uniprotkb:Q53HU1|uniprotkb:Q6UXN0|uniprotkb:Q9HBV4|uniprotkb:Q9Y5B3|uniprotkb:B4E089|uniprotkb:F5H0I2|uniprotkb:D6W670 psi-mi:heparan_sulfate(display_short)|psi-mi:"CHEBI:28815"(display_long) psi-mi:angl4_human(display_long)|uniprotkb:ANGPTL4(gene name)|psi-mi:ANGPTL4(display_short)|uniprotkb:ARP4(gene name synonym)|uniprotkb:HFARP(gene name synonym)|uniprotkb:PGAR(gene name synonym)|uniprotkb:Angiopoietin-like protein 4(gene name synonym)|uniprotkb:Hepatic fibrinogen/angiopoietin-related protein(gene name synonym)|uniprotkb:PP1158(orf name)|uniprotkb:PSEC0166(orf name)|uniprotkb:UNQ171/PRO197(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Chomel et al. (2009) pubmed:19019854 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0917"(matrixdb) intact:EBI-12600014 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) matrixdb:GAG_2(source reference) ensembl:ENSG00000167772(gene)|ensembl:ENST00000301455(transcript)|ensembl:ENST00000593998(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043335"(protein unfolding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0072562"(blood microparticle)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)|interpro:IPR020837|interpro:IPR028793|interpro:IPR036056|rcsb pdb:6EUB|rcsb pdb:6U0A|rcsb pdb:6U1U|rcsb pdb:6U73|reactome:R-HSA-1989781|reactome:R-HSA-381340|reactome:R-HSA-8963889|refseq:NP_001034756.1|refseq:NP_647475.1 - - - figure legend:Table 1|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2016/11/18 2016/11/22 - rogid:SYEgNUqLXqm2qltwii+aJA+fxkY9606 - false - myc tag:c-c|his tag:c-c|sufficient binding region:22-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)