#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:17552"	uniprotkb:P60953	intact:EBI-1265684	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639549|imex:IM-25725-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:2 B/C|comment:The exchange activity of Asef2 was only detected with the lipid-modified form of Cdc42.  [The exact nature of this lipid-modification is not stated and could involve more than one type of PTM.]|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/21	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:P60953	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639549|imex:IM-25725-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2 B/C|comment:The exchange activity of Asef2 was only detected with the lipid-modified form of Cdc42.  [The exact nature of this lipid-modification is not stated and could involve more than one type of PTM.]|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/21	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	-	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639549|imex:IM-25725-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:2 B/C|comment:The exchange activity of Asef2 was only detected with the lipid-modified form of Cdc42.  [The exact nature of this lipid-modification is not stated and could involve more than one type of PTM.]|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/21	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	his tag:n-n|flag tag:n-n|sufficient binding region:205-652	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	chebi:"CHEBI:15996"	intact:EBI-1265684	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639691|imex:IM-25725-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	figure legend:2 D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	-	-	false	3h radiolabel:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P63000	intact:EBI-1265684	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639691|imex:IM-25725-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:2 D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P15498	intact:EBI-1265684	intact:EBI-625518|ensembl:ENSP00000472929|uniprotkb:Q15860|uniprotkb:B4DVK9|uniprotkb:M0QXX6	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:vav_human(display_long)|uniprotkb:VAV1(gene name)|psi-mi:VAV1(display_short)|uniprotkb:VAV(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639691|imex:IM-25725-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0072593"(reactive oxygen species metabolic process)|ensembl:ENSG00000141968(gene)|ensembl:ENST00000602142(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030168"(platelet activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031295"(T cell costimulation)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P15498|rcsb pdb:2CRH|rcsb pdb:2LCT|rcsb pdb:2MC1|rcsb pdb:2ROR|rcsb pdb:3BJI|rcsb pdb:3KY9|rcsb pdb:6NEW|rcsb pdb:6NF1|rcsb pdb:6NFA|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-389359|reactome:R-HSA-416482|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5218920|reactome:R-HSA-6811558|reactome:R-HSA-8980692|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9027284|reactome:R-HSA-912631|reactome:R-HSA-9664422|reactome:R-HSA-983695|reactome:R-HSA-9013404|refseq:NP_005419.2|refseq:NP_001245136.1|dip:DIP-1061N	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:2 D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:bQbV6leh4WHm+d0VGVCMuZtR6pU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	maltose binding protein tag:n-n|sufficient binding region:194..194-504..504	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P60953	intact:EBI-1265684	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639728|imex:IM-25725-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:2 D|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:P60953	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639728|imex:IM-25725-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:2 D|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	-	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q9NR80-3	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13639160|ensembl:ENSP00000348017	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q9nr80-3(display_long)|uniprotkb:ARHGEF4(gene name)|psi-mi:ARHGEF4(display_short)|uniprotkb:KIAA1112(gene name synonym)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 1(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639728|imex:IM-25725-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000136002(gene)|ensembl:ENST00000355771(transcript)|intact:EBI-3389984(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:2 D|comment:positive control|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:rQ+S7eEG4jgncxNuw5jM7jtsqPw9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	his tag:n-n|flag tag:n-n|sufficient binding region:181-619	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P25054	uniprotkb:P60953	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639968|imex:IM-25725-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:5A|comment:The MBP-APC-arm construct stimulated Asef2 activity to a level that was comparable to the Delta-204 truncation mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	maltose binding protein tag:n-n|sufficient binding region:205-885	sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P25054	intact:EBI-1265684	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639968|imex:IM-25725-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:5A|comment:The MBP-APC-arm construct stimulated Asef2 activity to a level that was comparable to the Delta-204 truncation mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	maltose binding protein tag:n-n|sufficient binding region:205-885	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:P25054	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639968|imex:IM-25725-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:5A|comment:The MBP-APC-arm construct stimulated Asef2 activity to a level that was comparable to the Delta-204 truncation mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	-	false	-	maltose binding protein tag:n-n|sufficient binding region:205-885	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P25054	uniprotkb:Q96N96-1	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639968|imex:IM-25725-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:5A|comment:The MBP-APC-arm construct stimulated Asef2 activity to a level that was comparable to the Delta-204 truncation mutant.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	maltose binding protein tag:n-n|sufficient binding region:205-885	his tag:n-n|flag tag:n-n|sufficient binding region:205-652	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P60953	intact:EBI-1265684	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640406|imex:IM-25725-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:P60953	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640406|imex:IM-25725-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	-	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640406|imex:IM-25725-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	glutathione s tranferase tag:n-n|sufficient binding region:90-204	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640406|imex:IM-25725-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:6E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	his tag:n-n|flag tag:n-n|sufficient binding region:205-652	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P60953	intact:EBI-1265684	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640882|imex:IM-25725-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:P60953	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640882|imex:IM-25725-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	-	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640882|imex:IM-25725-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	maltose binding protein tag:?-?|sufficient binding region:561-652	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640882|imex:IM-25725-20	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:7C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	his tag:n-n|flag tag:n-n|sufficient binding region:205-652	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:17552"	uniprotkb:P60953	intact:EBI-1265684	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gdp(display_short)|psi-mi:"CHEBI:17552"(display_long)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640911|imex:IM-25725-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:8D|comment:The expression system and tags are not stated for the 204 to 620 tail deletion fragment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	3h radiolabel:?-?|sufficient binding region:?-?	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
chebi:"CHEBI:15996"	uniprotkb:P60953	intact:EBI-989053|chebi:"CHEBI:42934"|chebi:"CHEBI:5234"|chebi:"CHEBI:13342"|chebi:"CHEBI:24451"	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	psi-mi:gtp(display_short)|psi-mi:"CHEBI:15996"(display_long)|intact:5'-GTP(synonym)|intact:GTP(synonym)|intact:Guanosine 5'-triphosphate(synonym)|intact:guanosine 5'-triphosphoric acid(synonym)|intact:guanosine triphosphate(synonym)|intact:GUANOSINE-5'-TRIPHOSPHATE(synonym)|intact:H4gtp(synonym)|intact:"guanosine 5'-(tetrahydrogen triphosphate)"(iupac name)	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640911|imex:IM-25725-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	author-identifiers:"InChI=1/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1/f/h14,19-20,22,24H,11H2"	-	figure legend:8D|comment:The expression system and tags are not stated for the 204 to 620 tail deletion fragment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	-	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	-	false	-	lipoconjugated residue:?-?|sufficient binding region:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640911|imex:IM-25725-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:8D|comment:The expression system and tags are not stated for the 204 to 620 tail deletion fragment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	maltose binding protein tag:?-?|sufficient binding region:561-652	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P60953	uniprotkb:Q96N96-1	intact:EBI-81752|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q7L8R5|uniprotkb:Q9UDI2|ensembl:ENSP00000341072|ensembl:ENSP00000383118|ensembl:ENSP00000497733|ensembl:ENSP00000499457|ensembl:ENSP00000499612	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:cdc42_human(display_long)|uniprotkb:CDC42(gene name)|psi-mi:CDC42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0949"(gdp/gtp exchange assay)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640911|imex:IM-25725-21	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034891.1|refseq:NP_001782.1|refseq:NP_426359.1|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0005886"(plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0005911"(cell-cell junction)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0031996"(thioesterase binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|ensembl:ENSG00000070831(gene)|ensembl:ENST00000344548(transcript)|ensembl:ENST00000400259(transcript)|ensembl:ENST00000648594(transcript)|ensembl:ENST00000656825(transcript)|ensembl:ENST00000662562(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60953|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0048664"(neuron fate determination)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|dip:DIP-31097N|reactome:R-HSA-983231|rcsb pdb:1AJE|rcsb pdb:1AM4|rcsb pdb:1AN0|rcsb pdb:1CEE|rcsb pdb:1CF4|rcsb pdb:1DOA|rcsb pdb:1E0A|rcsb pdb:1EES|rcsb pdb:1GRN|rcsb pdb:1GZS|rcsb pdb:1KI1|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1NF3|rcsb pdb:2ASE|rcsb pdb:2DFK|rcsb pdb:2KB0|rcsb pdb:2NGR|rcsb pdb:2ODB|rcsb pdb:2QRZ|rcsb pdb:2WM9|rcsb pdb:2WMN|rcsb pdb:2WMO|rcsb pdb:3GCG|rcsb pdb:3QBV|rcsb pdb:3VHL|rcsb pdb:4DID|rcsb pdb:4ITR|rcsb pdb:4JS0|rcsb pdb:4YC7|rcsb pdb:4YDH|rcsb pdb:5CJP|rcsb pdb:5FI1|rcsb pdb:5HZK|rcsb pdb:5UPK|rcsb pdb:5UPL|rcsb pdb:6AJ4|rcsb pdb:6AJL|rcsb pdb:6SIU|rcsb pdb:6SUP|rcsb pdb:6TKY|rcsb pdb:6TKZ|reactome:R-HSA-114604|reactome:R-HSA-182971|reactome:R-HSA-2029482|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-525793|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5687128|reactome:R-HSA-8950505|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|rcsb pdb:1A4R|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9664422	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)	-	-	figure legend:8D|comment:The expression system and tags are not stated for the 204 to 620 tail deletion fragment.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	-	false	lipoconjugated residue:?-?|sufficient binding region:?-?	sufficient binding region:204-620	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P25054	uniprotkb:Q96N96	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-13618641|ensembl:ENSP00000371527|uniprotkb:A2VEA9|uniprotkb:A6NF85|uniprotkb:B4DQB1|uniprotkb:B4DSZ0|uniprotkb:B4DVM8|uniprotkb:J3KPJ7|uniprotkb:J3KQH2|uniprotkb:Q5VX68|uniprotkb:Q6ZML1|uniprotkb:Q8N873|uniprotkb:Q8TEK6	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:spt13_human(display_long)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639774|imex:IM-25725-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036028|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:NP_001159743.1|refseq:NP_001273721.1|refseq:NP_001273722.1|refseq:NP_001273723.1|refseq:NP_001273724.1|refseq:NP_694568.1	-	-	-	figure legend:4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sw480)|taxid:9606(Human SW480 adenocarcinoma cell line)	-	2016/12/20	2017/01/31	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:Q96N96	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-13618641|ensembl:ENSP00000371527|uniprotkb:A2VEA9|uniprotkb:A6NF85|uniprotkb:B4DQB1|uniprotkb:B4DSZ0|uniprotkb:B4DVM8|uniprotkb:J3KPJ7|uniprotkb:J3KQH2|uniprotkb:Q5VX68|uniprotkb:Q6ZML1|uniprotkb:Q8N873|uniprotkb:Q8TEK6	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:spt13_human(display_long)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639778|imex:IM-25725-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036028|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:NP_001159743.1|refseq:NP_001273721.1|refseq:NP_001273722.1|refseq:NP_001273723.1|refseq:NP_001273724.1|refseq:NP_694568.1	-	-	-	figure legend:4Ai|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-sw480)|taxid:9606(Human SW480 adenocarcinoma cell line)	-	2016/12/20	2017/01/31	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25054	uniprotkb:Q96N96	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	intact:EBI-13618641|ensembl:ENSP00000371527|uniprotkb:A2VEA9|uniprotkb:A6NF85|uniprotkb:B4DQB1|uniprotkb:B4DSZ0|uniprotkb:B4DVM8|uniprotkb:J3KPJ7|uniprotkb:J3KQH2|uniprotkb:Q5VX68|uniprotkb:Q6ZML1|uniprotkb:Q8N873|uniprotkb:Q8TEK6	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:spt13_human(display_long)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639782|imex:IM-25725-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036028|reactome:R-HSA-9013148|reactome:R-HSA-9013149|refseq:NP_001159743.1|refseq:NP_001273721.1|refseq:NP_001273722.1|refseq:NP_001273723.1|refseq:NP_001273724.1|refseq:NP_694568.1	-	-	-	figure legend:4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-panc04-03)|taxid:9606(human-panc04-03  Pancreatic ductal adenocarcinoma cell line)	-	2016/12/20	2017/01/31	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q96N96-1	uniprotkb:P25054	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639801|imex:IM-25725-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2016/12/20	2017/02/21	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	flag tag:n-n|necessary binding region:173-204	sufficient binding region:205-885|mutation:204-205	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:P63000	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-413628|ensembl:ENSP00000258737|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q3Y4D3|uniprotkb:Q5JAA8|uniprotkb:Q9BTB4	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:rac1_human(display_long)|uniprotkb:RAC1(gene name)|psi-mi:RAC1(display_short)|uniprotkb:MIG5(orf name)|uniprotkb:p21-Rac1(gene name synonym)|uniprotkb:Ras-like protein TC25(gene name synonym)|uniprotkb:Cell migration-inducing gene 5 protein(gene name synonym)|uniprotkb:TC25(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639522|imex:IM-25725-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	ensembl:ENSG00000136238(gene)|ensembl:ENST00000348035(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001764"(neuron migration)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006954"(inflammatory response)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042470"(melanosome)|reactome:R-HSA-2424491|refseq:NP_008839.2|refseq:NP_061485.1|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P63000|rcsb pdb:1E96|rcsb pdb:1FOE|rcsb pdb:1G4U|rcsb pdb:1HE1|rcsb pdb:1HH4|rcsb pdb:1I4D|rcsb pdb:1I4L|rcsb pdb:1I4T|rcsb pdb:1MH1|rcsb pdb:1RYF|rcsb pdb:1RYH|rcsb pdb:2FJU|rcsb pdb:2H7V|rcsb pdb:2NZ8|rcsb pdb:2P2L|rcsb pdb:2RMK|rcsb pdb:2VRW|rcsb pdb:2WKP|rcsb pdb:2WKQ|rcsb pdb:2WKR|rcsb pdb:2YIN|rcsb pdb:3B13|rcsb pdb:3BJI|rcsb pdb:3RYT|rcsb pdb:3SBD|rcsb pdb:3SBE|rcsb pdb:3SU8|rcsb pdb:3SUA|rcsb pdb:3TH5|rcsb pdb:4GZL|rcsb pdb:4GZM|rcsb pdb:4YON|rcsb pdb:5FI0|rcsb pdb:5HZH|rcsb pdb:5N6O|rcsb pdb:5O33|rcsb pdb:5QQD|rcsb pdb:5QQE|rcsb pdb:5QQF|rcsb pdb:5QQG|rcsb pdb:5QQH|rcsb pdb:5QQI|rcsb pdb:5QQJ|rcsb pdb:5QQK|rcsb pdb:5QQL|rcsb pdb:5QQM|rcsb pdb:5QQN|rcsb pdb:5QU9|rcsb pdb:6AGP|rcsb pdb:6BC1|rcsb pdb:6TGC|rcsb pdb:6X1G|rcsb pdb:7AJK|reactome:R-HSA-114604|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1445148|reactome:R-HSA-164944|reactome:R-HSA-193648|reactome:R-HSA-2029482|reactome:R-HSA-2219530|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048261"(negative regulation of receptor-mediated endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|reactome:R-HSA-389359|reactome:R-HSA-399954|reactome:R-HSA-399955|reactome:R-HSA-4086400|reactome:R-HSA-416550|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-428543|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-5218920|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5663213|reactome:R-HSA-5663220|reactome:R-HSA-5668599|reactome:R-HSA-5687128|reactome:R-HSA-6798695|reactome:R-HSA-6811558|reactome:R-HSA-8849471|reactome:R-HSA-8875555|reactome:R-HSA-9013149|reactome:R-HSA-9032759|reactome:R-HSA-9032845|reactome:R-HSA-9619229|reactome:R-HSA-9664422|reactome:R-HSA-9673324|reactome:R-HSA-983231|reactome:R-HSA-2871796|reactome:R-HSA-376172|dip:DIP-29260N	-	-	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/30	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A9606	rigid:unm1olvTLZ664aXzcnIDM2iooO8	false	flag tag:n-n|sufficient binding region:205-652	glutathione s tranferase tag:n-n|mutation:17-17	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:P25054	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639825|imex:IM-25725-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	figure legend:4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	glutathione s tranferase tag:n-n|sufficient binding region:133-204	sufficient binding region:205-885|mutation:204-205	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NR80-3	uniprotkb:P25054	intact:EBI-13639160|ensembl:ENSP00000348017	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:q9nr80-3(display_long)|uniprotkb:ARHGEF4(gene name)|psi-mi:ARHGEF4(display_short)|uniprotkb:KIAA1112(gene name synonym)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 1(gene name synonym)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13639878|imex:IM-25725-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000136002(gene)|ensembl:ENST00000355771(transcript)|intact:EBI-3389984(isoform-parent)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	-	-	-	figure legend:4Ei|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:rQ+S7eEG4jgncxNuw5jM7jtsqPw9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rigid:O2gFlYjaml6z9kfuCwM1WM021b8	false	glutathione s tranferase tag:n-n|sufficient binding region:73-148	sufficient binding region:205-885|mutation:204-205	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:Q96N96-1	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640181|imex:IM-25725-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	-	-	-	figure legend:6C-top|comment:The cells expressing  Flag tagged Asef proteins may have been HeLa cells.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:5engOT8rG8kjItYQe3XFdChZw90	false	glutathione s tranferase tag:n-n|sufficient binding region:90-204	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:Q9NR80-3	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-13639160|ensembl:ENSP00000348017	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:q9nr80-3(display_long)|uniprotkb:ARHGEF4(gene name)|psi-mi:ARHGEF4(display_short)|uniprotkb:KIAA1112(gene name synonym)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640301|imex:IM-25725-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	ensembl:ENSG00000136002(gene)|ensembl:ENST00000355771(transcript)|intact:EBI-3389984(isoform-parent)	-	-	-	figure legend:6C-bottom|comment:The cells expressing  Flag tagged Asef proteins may have been HeLa cells.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:rQ+S7eEG4jgncxNuw5jM7jtsqPw9606	rigid:BZ2wD1mMf/peQ2f2iBYVXLNspXk	false	glutathione s tranferase tag:n-n|sufficient binding region:90-204	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:Q96N96-1	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640339|imex:IM-25725-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	-	-	-	figure legend:6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/01/31	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:5engOT8rG8kjItYQe3XFdChZw90	false	glutathione s tranferase tag:n-n|sufficient binding region:90-204	flag tag:n-n|his tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:Q96N96-1	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640801|imex:IM-25725-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	-	-	-	figure legend:7A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:5engOT8rG8kjItYQe3XFdChZw90	false	glutathione s tranferase tag:n-n|sufficient binding region:90-204	flag tag:n-n|sufficient binding region:205-652|necessary binding region:562-652	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:Q96N96-1	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-13638906|ensembl:ENSP00000371527	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:"MI:0096"(pull down)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640859|imex:IM-25725-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	-	-	-	figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2016/12/20	2017/02/01	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rigid:5engOT8rG8kjItYQe3XFdChZw90	false	sufficient binding region:90-173|maltose binding protein tag:?-?|sufficient binding region:90-204|sufficient binding region:133-204	glutathione s tranferase tag:n-n|sufficient binding region:562-652	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96N96-1	uniprotkb:P25054	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640008|imex:IM-25725-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0030175"(filopodium)	-	-	figure legend:5C|comment:The Asef2 Delta 204 mutant induced filopodia formation but did not accumulate/colocalise in them in the presence of YFP-APC-arm.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bxpc3)|taxid:9606(Homo sapiens primary pancreatic adenocarcinoma cell line)	-	2016/12/20	2017/01/31	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	flag tag:n-n	sufficient binding region:205-885|yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q96N96-1	uniprotkb:P25054	intact:EBI-13638906|ensembl:ENSP00000371527	intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089	psi-mi:q96n96-1(display_long)|uniprotkb:APC-stimulated guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:ASEF-2b(isoform synonym)|uniprotkb:SPATA13(gene name)|psi-mi:SPATA13(display_short)	psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hamann et al. (2007)	pubmed:17145773|imex:IM-25725	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-13640164|imex:IM-25725-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000182957(gene)|ensembl:ENST00000382095(transcript)|intact:EBI-13618641(isoform-parent)	refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896	go:"GO:0071944"(cell periphery)	-	-	figure legend:5Ci|comment:The Asef2 Delta 204 mutant induced filopodia formation but did not accumulate/colocalise in them in the presence of YFP-APC-arm.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-bxpc3)|taxid:9606(Homo sapiens primary pancreatic adenocarcinoma cell line)	-	2016/12/20	2017/01/31	rogid:nFB364MMLth1jm5AqF21viJ+Fas9606	rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606	rigid:XoiowgqK8HWdgRCReOdzR/yoHO8	false	flag tag:n-n|sufficient binding region:205-652	sufficient binding region:205-885|yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:0867"(tag visualisation by fluorescence)